Male infertility

N14_MALEINFERT

male infertility: The inability of the male to effect fertilization of an ovum after a specified period of unprotected intercourse. Male sterility is permanent infertility.

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Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

only males

226754

2. Check conditions

None

226754

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 N46
  • Hospital discharge: ICD-9 606
  • Hospital discharge: ICD-8 606
  • Cause of death: ICD-10 N46
  • Cause of death: ICD-9 606
  • Cause of death: ICD-8 606

2 out of 7 registries used, show all original rules.

2061

4. Check minimum number of events

None

2061

5. Include endpoints

None

2061

6. Filter based on genotype QC (FinnGen only)

1911

Control definitions (FinnGen only)

Control exclude
N14_MALEGEN

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N40-N51
Name in latin
Infertilitas masculina

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 18987 - 18987
Only index persons 18715 - 18715
Unadjusted period prevalence (%)
Whole population 0.53 - 0.53
Only index persons 0.71 - 0.71
Median age at first event (years)
Whole population - - 33.28
Only index persons - - 33.23

-FinnGen-

Key figures

All Female Male
Number of individuals 1911 - 1911
Unadjusted period prevalence (%) 0.88 - 0.88
Median age at first event (years) 33.82 - 33.82

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
2061
Matched controls
20610
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Z31.4
ICD-10 Finland
Procreative investigation and testing
9.1
307.7
548
791
N46
ICD-10 Finland
Male infertility
5180.5
307.7
1866
38
KF8AE
NOMESCO Finland
Ultrasound examination of scrotum
10.9
178.2
200
202
L02BG04
ATC
letrozole; oral
32.8
159.4
103
33
60699
ICD-8 Finland
Sterility, male
+∞
115.7
110
*
KGH10
NOMESCO Finland
Operation for phimosis
57.5
99.3
56
10
G03GA01
ATC
chorionic gonadotrophin; parenteral
21.0
91.0
69
34
KFB00
NOMESCO Finland
Biopsy of testis
123.5
77.5
83
7
N47
ICD-10 Finland
Redundant prepuce, phimosis and paraphimosis
12.7
76.4
75
61
Z31.6
ICD-10 Finland
General counselling and advice on procreation
7.2
72.0
110
161
W15
ICPC
Infertility/subfertility female
22.3
67.7
50
23
121
Kela drug reimbursment
Severe hypofunction of sexual glands
9.5
62.5
75
82
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
3.2
56.3
244
827
N43.3
ICD-10 Finland
Hydrocele, unspecified
18.0
48.2
39
22
KFB01
NOMESCO Finland
Microscope-assisted testicular biopsy for assisted reproduction treatments
+∞
45.0
43
*
6060A
ICD-9 Finland
Infertility, male, Azoospermia
+∞
39.7
38
*
N45.9
ICD-10 Finland
Orchitis, epididymitis and epididymo-orchitis without abscess
6.6
37.6
61
95
TKF00
NOMESCO Finland
Needle biopsy of testis
363.5
36.1
36
*
60500
ICD-8 Finland
Redundant prepuce and phimosis, Phimosis
+∞
33.4
32
*
WZC00
NOMESCO Finland
Treatment plan or consultation
1.8
32.4
624
3945
XKD00
NOMESCO Finland
Uroflowmetry
2.9
32.0
162
595
KFC00
NOMESCO Finland
Unilateral orchiectomy
5.8
28.2
52
92
N40
ICD-10 Finland
Hyperplasia of prostate
2.5
28.2
181
750
E29.1
ICD-10 Finland
Testicular hypofunction
3.4
26.4
95
285
KFH30
NOMESCO Finland
Vasovasostomy
136.7
25.7
27
*
Z31.5
ICD-10 Finland
Genetic counselling
3.1
24.4
105
352
7501
FHL
Testicular exploration (includes removal of biopsy, detorsion or appendix test)
34.9
24.3
31
9
G03GA05
ATC
follitropin alfa; parenteral
+∞
24.0
23
*
N43.4
ICD-10 Finland
Spermatocele
6.8
23.8
37
55
6050A
ICD-9 Finland
Redundant prepuce and phimosis[PHIMOSIS]
+∞
23.0
22
*
N97.4
ICD-10 Finland
Female infertility associated with male factors
84.4
22.7
25
*
UKC02
NOMESCO Finland
Cystoscopy
2.4
21.5
149
639
101
Kela drug reimbursment
Anterior pituitary hypofunction
5.0
20.9
45
92
127
Kela drug reimbursment
Transplant complication
4.2
20.9
56
137
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
2.5
20.3
131
544
KE1BE
NOMESCO Finland
Rectal ultrasound examinaiton of prostata
3.4
20.2
73
220
D40.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Testis
4.6
19.6
46
101
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
3.2
18.3
73
234
6069X
ICD-9 Finland
Infertility, male, Male infertility, unspecified
+∞
17.7
17
*
J01MA02
ATC
ciprofloxacin; systemic
1.6
17.7
535
3718
KFD20
NOMESCO Finland
Excision of hydrocele of testis
63.9
16.7
19
*
XJH00
NOMESCO Finland
Transanal ultrasonography
4.1
16.6
45
111
N44
ICD-10 Finland
Torsion of testis
90.8
16.6
18
*
L04AA01
ATC
[U] ciclosporin
5.6
16.0
30
54
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
3.8
16.0
48
128
L04AA06
ATC
mycophenolic acid; systemic
3.4
15.8
56
167
6061A
ICD-9 Finland
Infertility, male, Oligospermia
+∞
15.6
15
*
SPAT1312
SPAT
General health counselling
1.6
15.6
447
3054
L02BA01
ATC
tamoxifen; oral
11.8
15.5
28
24
SPAT1249
SPAT
Treatment-related counselling outside office
1.6
15.5
522
3699
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
7.0
15.3
23
33
7542
FHL
Circumcisio
28.8
15.2
20
7
Q98.0
ICD-10 Finland
Klinefelter syndrome karyotype 47,XXY
17.9
15.1
23
13
T91.3
ICD-10 Finland
Sequelae of injury of spinal cord
17.9
15.1
23
13
KED22
NOMESCO Finland
Transurethral resection of prostate
23.6
15.1
21
9
SPAT1308
SPAT
Sexual health counselling
2.9
14.9
70
247
A55
ICPC
General and Unspecified, Local injection/infiltration
3.7
14.8
47
130
XKC03
NOMESCO Finland
Water cystometry
6.2
14.7
25
41
SAB01
NOMESCO Finland
Restricted oral and dental health check by dental hygienist or dental assistant
2.1
14.6
140
687
6068A
ICD-9 Finland
Infertility, male, Infertility due to extratesticular causes
+∞
14.6
14
*
Z00.0
ICD-10 Finland
General medical examination
1.7
14.0
303
1928
N97.9
ICD-10 Finland
Female infertility, unspecified
15.9
13.9
22
14
7527
FHL
Vasoepididymostomy
+∞
13.6
13
*
G04CA02
ATC
tamsulosin; oral
1.7
12.8
272
1720
Z3232
NOMESCO Finland
Midwife
32.2
12.6
16
5
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.3
12.5
94
419
SPAT1197
SPAT
Extensive health check-up of expecting family
2.4
12.4
82
345
F20.9
ICD-10 Finland
Schizophrenia, unspecified
0.1
12.4
*
369
N02BE01
ATC
paracetamol; systemic, rectal
1.5
12.3
1530
13680
Z94.0
ICD-10 Finland
Kidney transplant status
3.7
12.2
38
104
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
4.8
12.1
27
57
XKD06
NOMESCO Finland
Physiologic investigation of micturition
4.3
12.0
30
70
C62.11
ICD-10 Finland
Malignant tumor of the descending testicle, seminoma
5.0
11.9
25
50
-, ,
ICD-10 Finland
3.4
11.9
42
125
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
4.0
11.9
33
83
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
4.0
11.7
32
80
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
4.3
11.5
29
68
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
0.1
11.5
*
376
G04CA01
ATC
alfuzosin; oral
1.8
11.4
188
1107
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
0.3
11.4
42
1169
M01AC06
ATC
meloxicam; systemic, rectal
1.5
11.1
475
3505
RD211, ,
NOMESCO Finland
2.6
11.1
62
241
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
11.0
225
1407
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
3.2
11.0
43
137
Z31.2
ICD-10 Finland
In vitrofertilization
12.0
10.8
19
16
N50.8
ICD-10 Finland
Other specified disorders of male genital organs
4.5
10.7
26
59
Q98.4
ICD-10 Finland
Klinefelter syndrome, unspecified
21.6
10.7
15
7
SPAT1153
SPAT
Removal of sutures
1.5
10.5
377
2685
7525
FHL
Detection of vas deferens for exploration (possibly vasotomy or vasography)
+∞
10.4
10
*
WZC30
NOMESCO Finland
Teaching
1.7
10.3
204
1266
J01EA01
ATC
trimethoprim; systemic
2.3
10.2
76
338
R50.9
ICD-10 Finland
Fever, unspecified
1.6
10.1
240
1557
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
4.2
10.1
26
62
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.5
10.0
366
2612
H02AB09
ATC
hydrocortisone; systemic
2.9
10.0
46
161
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.5
10.0
351
2486
N05AH02
ATC
clozapine; systemic
0.1
10.0
6
405
M03BX02
ATC
tizanidine; oral
1.3
9.9
1132
9781
D19
ICPC
Teeth/gum symptom/complaint
1.4
9.9
470
3527
N18.8
ICD-10 Finland
Other chronic renal failure
3.4
9.9
35
105
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
0.0
9.8
*
279
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
3.8
9.8
29
77
A98
ICPC
Health maint/preventive medicine
2.0
9.8
1969
18852
L04AD02
ATC
tacrolimus; systemic
3.2
9.7
37
116
JONO, ,
NOMESCO Finland
3.4
9.7
34
101
J01AA02
ATC
doxycycline; systemic
1.3
9.6
1219
10677
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.3
9.6
74
334
F29
ICD-10 Finland
Unspecified nonorganic psychosis
0.3
9.5
21
763
P72
ICPC
Schizophrenia
0.1
9.5
*
322
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.8
9.5
131
732
KFD96
NOMESCO Finland
Other excision or ligature of scrotal organs
100.5
9.4
10
*
KFD30
NOMESCO Finland
Operation for spermatocele
30.2
9.4
12
*
6030A
ICD-9 Finland
Hydrocele, Encysted hydrocele
+∞
9.4
9
*
9061/3-C62.9
ICD-O-3
Seminoma, NOS, of testis, NOS
6.9
9.3
22
32
SCA01
NOMESCO Finland
Preventive oral health care, short
1.4
9.1
468
3557
KFA00
NOMESCO Finland
Exploration of testis
15.6
9.0
14
9
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
9.0
267
1822
SPAT1195
SPAT
Antenatal classes
2.1
9.0
81
390
Y10
ICPC
Infertility/subfertility male
10.7
8.8
16
15
Y28
ICPC
Limited function/disability (Y)
4.1
8.7
23
56
N43.0
ICD-10 Finland
Encysted hydrocele
50.2
8.7
10
*
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.3
8.7
1044
9019
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.7
8.5
148
886
A11CC03
ATC
alfacalcidol; systemic
2.9
8.5
39
137
N48.1
ICD-10 Finland
Balanoposthitis
2.3
8.4
60
262
JN4BD
NOMESCO Finland
Extensive body CT
1.8
8.4
117
655
7526
FHL
Vasovasostomy
90.4
8.4
9
*
N05AH03
ATC
olanzapine; systemic
0.4
8.4
46
1073
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
8.4
600
4802
7503
FHL
Hydrosel or funicular surgery
12.8
8.4
14
11
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
3.3
8.4
31
96
A02BC02
ATC
pantoprazole; systemic
1.3
8.3
978
8401
UJF32
NOMESCO Finland
Coloscopy
1.5
8.2
280
1968
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.1
8.2
71
337
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.3
8.1
731
6044
A12AA04
ATC
calcium carbonate; oral
3.3
8.1
29
88
45610
ICD-8 Finland
Varicose veins of other sites, Of scrotum
10.1
8.0
15
15
KFH10
NOMESCO Finland
Orchiopexy
22.1
8.0
11
5
75210
ICD-8 Finland
Congenital anomalies of genital organs, Undescended testicle
2.8
8.0
39
142
L04AD01
ATC
ciclosporin; systemic
2.8
7.9
38
137
Z49.0
ICD-10 Finland
Preparatory care for dialysis
4.0
7.9
22
56
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
2.8
7.9
39
143
G95.8
ICD-10 Finland
Other specified diseases of spinal cord
13.1
7.9
13
10
N48.8
ICD-10 Finland
Other specified disorders of penis
8.5
7.8
16
19
G03GA06
ATC
follitropin beta; parenteral
45.1
7.7
9
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.0
7.7
79
400
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
3.2
7.7
30
96
WZA90
NOMESCO Finland
Other medical or dental certificate
1.4
7.6
370
2775
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
7.6
1357
12262
SPAT1360
SPAT
Extensive global examination
2.0
7.6
75
374
I86.1
ICD-10 Finland
Scrotal varices
2.5
7.6
46
187
SAA02
NOMESCO Finland
Basic examination of mouth
1.3
7.6
1251
11185
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
3.5
7.5
25
72
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.4
7.5
315
2303
SPAT1263
SPAT
Sampling
1.3
7.4
571
4605
KF8KT
NOMESCO Finland
Sclerotherapy of scrotum
80.4
7.4
8
*
G03GA02
ATC
human menopausal gonadotrophin; parenteral
80.4
7.4
8
*
N02AX02
ATC
tramadol; systemic, rectal
1.3
7.4
613
4998
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
3.1
7.3
30
99
KED52
NOMESCO Finland
Visual laser resection of prostate
+∞
7.3
7
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.4
7.3
346
2585
SPAT1399
SPAT
Acceptance of acknowledgement of paternity of child born outside of marriage before the birth of the child at the maternity clinic. Paternity Act, Section 16.
2.2
7.3
62
293
J02AC01
ATC
fluconazole; systemic
1.5
7.3
262
1861
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.0
7.2
76
389
J01MA06
ATC
norfloxacin; oral
2.0
7.2
79
410
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.3
7.2
485
3834
N31.2
ICD-10 Finland
Flaccid neuropathic bladder, not elsewhere classified
7.3
7.2
16
22
B03XA02
ATC
darbepoetin alfa; parenteral
3.1
7.2
29
95
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.6
7.1
164
1056
N41.1
ICD-10 Finland
Chronic prostatitis
2.4
7.1
47
199
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.2
7.1
55
250
Q53.1
ICD-10 Finland
Undescended testicle, unilateral
8.8
7.0
14
16
308
Kela drug reimbursment
Alprostadil, sildenafil and combination product containing aviptadil and phentolamine
3.6
7.0
22
61
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
1.9
7.0
86
464
H02AB04
ATC
methylprednisolone; systemic
1.6
6.9
164
1063
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
2.7
6.9
35
130
SPAT1301
SPAT
No procedures
1.4
6.9
355
2687
N31.8
ICD-10 Finland
Other neuromuscular dysfunction of bladder
13.8
6.9
11
8
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
1.8
6.9
91
503
N48.4
ICD-10 Finland
Impotence of organic origin
2.3
6.9
52
234
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
1.9
6.9
79
417
7505
FHL
Funicular lysis and orchidopexy
3.2
6.8
26
82
H01AC01
ATC
somatropin; parenteral
8.3
6.8
14
17
SPAT1216
SPAT
Assessment of functional ability
1.8
6.8
108
631
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.5
6.8
224
1563
TQW80
NOMESCO Finland
Local dermatologic skincare
2.5
6.8
39
155
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.4
6.8
328
2457
SPAT1229
SPAT
Assessment of need for aid
2.3
6.8
50
223
L03AA13
ATC
pegfilgrastim; parenteral
3.1
6.7
27
88
7525A
ICD-9 Finland
Congenital anomalies of genital organs, Undescended testicle[RETENTIO TESTIS (CRYPTORCHISMUS)]
3.2
6.7
26
83
J01MA12
ATC
levofloxacin; systemic
1.5
6.7
201
1376
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
0.2
6.7
8
350
SDE02
NOMESCO Finland
Periodontal treatment by dental hygienist
1.4
6.6
340
2570
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.3
6.6
1014
8916
R06AE07
ATC
cetirizine; oral
1.3
6.6
685
5738
N30.0
ICD-10 Finland
Acute cystitis
2.3
6.6
45
194
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
2.2
6.5
51
233
A02BC03
ATC
lansoprazole; oral
1.4
6.5
308
2299
SPAT1273
SPAT
Structured assessment of psychoactive substance / tobacco use
2.1
6.5
56
267
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.7
6.4
102
596
137
Kela drug reimbursment
Uraemia requiring dialysis
3.5
6.4
21
60
KED76
NOMESCO Finland
TUVP
70.1
6.4
7
*
R01AD09
ATC
mometasone; nasal
1.3
6.4
717
6059
SAD01
NOMESCO Finland
Assessment of need for oral health care, standard
1.5
6.4
203
1406
UDH02
NOMESCO Finland
Rhinopharyngoscopy
1.8
6.4
98
568
H02AB06
ATC
prednisolone; systemic
1.3
6.4
639
5325
KA1AE
NOMESCO Finland
Kidney ultrasound examination
2.5
6.4
38
154
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.4
6.3
334
2537
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
3.6
6.3
20
56
L89
ICD-10 Finland
Decubitus ulcer and pressure area
3.6
6.3
20
56
R03BA01
ATC
beclometasone; inhalant
1.6
6.3
161
1063
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
2.6
6.3
34
131
60300
ICD-8 Finland
Hydrocele, Tunicae vaginalis testis
+∞
6.3
6
*
WX240
NOMESCO Finland
Penis blockade
+∞
6.3
6
*
60301
ICD-8 Finland
Hydrocele, Funiculi testis
+∞
6.3
6
*
G82.4
ICD-10 Finland
Spastic tetraplegia
26.8
6.2
8
*
TK800
NOMESCO Finland
Hemodialysis
2.3
6.2
42
181
T99
ICPC
Endocr/metab/nutrit disease other
3.1
6.2
24
77
R01AD12
ATC
fluticasone furoate; nasal
1.3
6.2
514
4177
N50.9
ICD-10 Finland
Disorder of male genital organs, unspecified
3.5
6.2
20
57
SPAT1210
SPAT
Application of cast or individual aid
2.2
6.2
49
226
SPAT1325
SPAT
Vaccination
1.4
6.1
307
2310
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.7
6.1
119
735
M01AH05
ATC
etoricoxib; oral
1.3
6.1
1077
9587
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.6
6.1
122
760
T28
ICPC
Limited function/disability (T)
3.8
6.1
18
48
Z49.1
ICD-10 Finland
Extracorporeal dialysis
3.0
6.1
25
83
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.5
6.0
160
1066
C91.0
ICD-10 Finland
Acute lymphoblastic leukaemia [ALL]
6.7
6.0
14
21
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.4
6.0
297
2230

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
212
108
21.77
278.76
1.0
1.0
—
—
—
0
0
287
262
12.56
276.19
1.6
1.6
11.76
7.65
iu/l
3.86
202
214
411
685
7.25
245.06
1.8
1.6
6.43
4.36
u/l
7.89
319
577
680
1862
4.96
235.69
1.8
1.6
—
—
—
0
0
265
304
9.86
216.03
4.2
3.1
—
—
—
0
0
265
304
9.86
216.03
8.4
6.3
—
—
—
0
0
747
2708
3.76
169.30
1.9
1.6
—
—
—
0
0
750
2774
3.68
164.11
1.9
1.8
—
—
—
0
0
690
2863
3.12
119.26
3.2
2.2
14.95
14.81
nmol/l
0.19
652
2690
815
3927
2.78
104.43
2.0
2.0
—
—
—
0
0
90
68
13.79
95.96
1.4
1.3
11.82
9.05
u/l
0.65
77
53
217
538
4.39
80.09
1.9
1.8
256.27
269.84
mu/l
0.30
211
506
69
70
10.16
60.67
1.5
1.1
—
—
—
0
0
189
591
3.42
49.51
1.7
1.3
—
—
—
0
0
261
1038
2.73
44.77
2.6
1.9
214.36
220.45
pmol/l
0.37
251
995
79
141
5.79
42.51
1.8
1.6
—
—
—
0
0
319
1462
2.40
40.49
1.7
2.0
—
—
—
0
0
316
1463
2.37
39.12
2.5
1.8
30.99
34.89
nmol/l
4.06
311
1441
192
764
2.67
32.57
3.4
2.8
—
—
—
0
0
59
137
4.40
23.49
5.0
6.5
6.32
29.86
u/l
1.05
13
22
448
2847
1.73
21.51
4.4
2.8
0.00
0.01
estimate
1.23
135
932
1465
12511
1.59
19.51
3.3
3.3
2.99
2.32
mu/l
0.23
1384
11748
1166
9653
1.48
16.41
2.9
2.8
15.01
14.78
pmol/l
2.47
1090
8969
839
6515
1.49
16.30
3.4
2.6
1.53
1.40
ug/l
0.42
787
5964
747
5800
1.45
13.91
3.7
2.5
0.00
0.00
estimate
1.08
145
1018
39
100
3.96
13.71
1.6
1.4
0.13
0.12
nmol/l
0.31
30
83
659
5012
1.46
13.61
3.0
2.4
22.21
21.88
%
0.15
213
1248
746
5833
1.44
13.21
3.7
2.5
0.00
0.00
estimate
0.50
133
933
377
2566
1.57
13.16
3.5
2.7
1.02
1.02
kg/l
0.25
44
302
355
2385
1.59
13.10
3.4
2.6
—
—
—
0
0
739
5790
1.43
12.85
4.6
3.5
0.00
0.00
estimate
-0.00
144
1021
206
1207
1.79
12.74
2.5
2.2
351.24
358.83
nmol/l
0.28
190
1122
646
4977
1.43
12.17
3.2
2.4
5.79
5.84
ph
0.25
70
679
166
940
1.83
11.49
2.2
2.1
7.87
9.63
ug/l
0.40
149
850
246
1563
1.65
11.31
1.9
1.8
—
—
—
0
0
314
2163
1.53
10.21
4.2
2.3
1.63
2.50
e6/l
3.77
294
1972
774
6321
1.36
9.81
4.3
2.6
46.60
910.24
e6/l
—
10
86
338
2390
1.50
9.68
3.2
3.0
1463.52
1023.10
ng/l
0.41
285
1885
97
486
2.05
9.66
4.2
5.6
—
—
—
0
0
1131
9797
1.34
9.63
3.8
3.4
7.44
7.70
mm/h
0.30
1065
9282
479
3686
1.39
8.59
2.3
1.9
0.56
0.58
ug/l
0.26
221
1544
402
3015
1.41
8.35
3.9
2.6
—
—
—
0
0
396
2977
1.41
8.10
4.1
2.7
0.18
0.37
e6/l
2.69
327
2241
20
34
5.93
7.68
1.9
1.3
—
—
—
0
0
427
3286
1.38
7.55
4.4
2.7
20.98
131.09
e6/l
1.61
356
2523
480
3768
1.36
7.48
4.6
3.1
16.76
40.41
e6/l
1.63
389
2707
108
621
1.78
7.17
7.3
5.6
144.60
101.90
ng/l
1.50
98
586
1784
16863
1.43
7.03
11.7
9.1
—
—
—
0
0
25
76
3.32
6.97
24.8
17.5
129.94
123.11
ug/l
0.13
18
53
606
4971
1.31
6.90
2.7
2.4
—
—
—
0
0
1681
15749
1.37
6.84
13.4
10.5
23.77
23.64
mg/l
0.05
1293
11895
459
3632
1.34
6.70
2.6
2.3
2155.15
3191.46
umol/l
0.33
433
3365
1156
10327
1.27
6.60
8.4
7.3
72.57
75.72
u/l
2.56
1118
9900
915
7957
1.27
6.49
4.1
3.0
—
—
—
0
0
519
4211
1.31
6.31
1.8
1.7
—
—
—
0
0
368
2847
1.36
6.20
2.4
1.9
1.53
0.93
mg/l
0.91
256
1977
1954
18890
1.66
6.18
18.0
15.0
43.14
44.02
%
1.24
1901
18071
1960
18967
1.68
6.12
17.9
14.8
6.45
6.56
e9/l
1.76
1920
18532
1958
18947
1.67
6.06
17.8
14.7
30.24
30.27
pg
0.45
1944
18758
1958
18955
1.66
5.94
17.8
14.7
89.55
89.54
fl
0.05
1944
18766
1959
18969
1.66
5.91
18.0
14.8
146.42
147.47
g/l
2.73
1944
18766
829
7181
1.26
5.91
6.8
6.9
0.04
0.04
e9/l
0.34
748
6384
1958
18958
1.66
5.90
17.9
14.7
4.86
4.89
e12/l
2.31
1922
18524
1954
18910
1.64
5.89
17.9
14.8
243.01
244.34
e9/l
0.47
1922
18519
1760
16705
1.37
5.81
4.1
3.8
2.94
3.01
mmol/l
2.83
1677
16021
827
7173
1.26
5.79
6.8
6.9
0.57
0.60
e9/l
3.36
745
6374
27
97
2.81
5.73
2.2
1.6
—
—
—
0
0
140
918
1.56
5.68
1.2
1.2
—
—
—
0
0
247
1821
1.40
5.57
2.8
2.5
0.48
0.78
e6/l
1.79
161
985
1612
15137
1.30
5.53
14.5
11.5
139.66
139.77
mmol/l
1.21
1579
14780
73
407
1.82
5.44
3.9
4.5
1.13
1.40
mmol/l
3.23
73
399
846
7402
1.24
5.36
7.2
7.4
0.20
0.20
e9/l
0.10
777
6666
1743
16563
1.34
5.35
4.0
3.6
1.29
1.27
mmol/l
2.10
1677
15936
560
4677
1.27
5.32
3.2
2.8
55.57
77.64
ng/l
0.19
344
2647
71
396
1.82
5.29
1.8
1.7
—
—
—
0
0
915
8086
1.24
5.26
9.2
10.9
3.90
4.05
e9/l
1.21
827
7151
554
4631
1.27
5.20
2.6
2.2
72.09
68.86
nmol/l
2.13
522
4343
1621
15268
1.29
5.19
14.6
11.6
4.01
3.99
mmol/l
2.51
1585
14875
109
691
1.61
5.13
1.1
1.1
190.00
170.61
titre
—
5
18
1748
16640
1.33
5.12
4.0
3.6
4.72
4.79
mmol/l
2.57
1677
16026
176
1240
1.46
5.10
4.1
2.2
—
—
—
0
0
110
703
1.60
5.01
3.2
3.1
72.19
74.04
e9/l
0.20
88
511
220
1620
1.40
5.00
13.8
7.8
1.05
1.02
mmol/l
0.54
211
1543
1842
17690
1.39
4.98
9.7
8.3
34.04
35.82
u/l
2.91
1811
17321
390
3135
1.30
4.97
5.5
4.4
—
—
—
0
0
561
4720
1.26
4.95
3.1
2.5
175.15
180.79
ug/l
0.21
538
4482
167
1173
1.46
4.92
17.1
9.4
9.75
8.25
mmol/l
2.13
161
1126
722
6273
1.23
4.73
10.1
8.9
0.00
0.00
e9/l
1.86
615
5194
845
7466
1.22
4.70
6.8
6.9
1.89
2.00
e9/l
1.58
775
6752
1691
16069
1.29
4.69
3.7
3.3
1.42
1.49
mmol/l
2.28
1618
15414
282
2186
1.34
4.65
2.4
2.1
3.06
2.80
mg/l
1.23
254
1896
273
2114
1.34
4.53
4.2
2.4
585.94
591.00
mosm/kgh2o
0.11
244
1848
117
778
1.53
4.51
6.7
4.1
1.23
1.22
mmol/l
0.80
112
718
14
32
4.40
4.43
2.1
1.8
—
—
—
0
0
34
156
2.20
4.41
1.6
1.6
—
—
—
0
0
244
1866
1.35
4.40
2.9
2.2
—
—
—
0
0
223
1687
1.36
4.32
4.1
2.7
15.30
14.90
umol/l
0.31
214
1613
65
378
1.74
4.28
1.8
1.7
107.53
102.22
u/ml
0.27
18
74
767
6772
1.21
4.16
7.8
7.2
—
—
—
0
0
7
253
0.27
4.13
1.3
3.0
—
—
—
0
0
558
4775
1.23
4.12
9.5
7.2
1.20
1.20
mmol/l
0.07
527
4462
199
1492
1.37
4.08
4.4
2.8
27.04
25.76
%
0.57
181
1337
1535
14498
1.23
4.03
3.7
3.4
5.85
5.90
mmol/l
0.70
1460
13684
207
1569
1.35
3.97
4.2
2.7
2.32
2.35
g/l
0.27
196
1481
740
6534
1.21
3.97
6.7
6.3
11.04
12.45
umol/l
3.90
721
6251
95
623
1.55
3.94
1.1
1.2
142.47
133.73
iu/ml
0.07
40
218
118
817
1.47
3.80
8.9
12.1
94.55
93.76
%
1.23
118
812
108
735
1.50
3.78
5.0
6.1
—
—
—
0
0
17
61
2.80
3.69
2.0
1.9
4.91
1.00
u/field
0.52
11
30
257
2040
1.30
3.58
1.6
1.6
46320763.23
28619393.41
pmol/l
0.21
231
1803
607
5303
1.21
3.57
11.1
7.5
1.20
1.20
mmol/l
0.54
517
4550
116
811
1.46
3.57
9.0
12.2
0.79
0.68
%
2.39
116
805
1460
13787
1.20
3.52
13.9
13.1
14.72
14.32
%
0.55
1439
13545
136
985
1.41
3.46
5.9
4.5
0.69
0.56
%
0.27
39
325
15
53
2.84
3.36
1.1
1.1
—
—
—
0
0
133
966
1.40
3.34
6.2
5.0
0.03
0.30
%
0.62
34
269
56
337
1.68
3.33
1.8
1.5
—
—
—
0
0
1490
14130
1.20
3.28
4.9
4.3
38.82
38.77
mmol/mol
0.07
1422
13540
416
3545
1.22
3.13
3.4
2.2
—
—
—
0
0
1070
9899
1.17
3.08
3.3
2.9
—
—
—
0
0
137
1018
1.37
3.03
6.4
4.9
0.13
0.11
%
0.07
39
323
143
1070
1.36
3.03
6.2
4.8
1.14
0.90
%
0.46
45
375
396
3369
1.22
3.02
3.7
3.3
2.35
2.35
mmol/l
0.20
372
3086
104
1442
0.71
3.02
2.1
2.5
—
—
—
0
0
391
3323
1.22
3.01
4.3
3.5
432.18
355.20
mg/l
0.11
286
2352
132
1760
0.73
3.01
1.9
2.5
—
—
—
0
0
114
822
1.41
3.01
1.5
1.4
—
—
—
0
0
368
3111
1.22
2.99
1.3
1.3
1.42
1.87
u/ml
0.53
143
922
15
57
2.64
2.96
1.0
1.0
4.58
5.28
iu/ml
—
5
16
34
184
1.86
2.92
9.5
4.4
—
—
—
0
0
22
102
2.17
2.87
5.3
5.3
—
—
—
0
0
45
732
0.61
2.85
3.3
3.6
—
—
—
0
0
121
895
1.37
2.77
1.3
1.3
404.06
327.41
u/ml
0.17
116
837
41
240
1.72
2.75
1.2
1.2
—
—
—
0
0
35
196
1.80
2.72
1.3
1.2
—
—
—
0
0
35
197
1.79
2.68
2.5
2.4
—
—
—
0
0
5
171
0.29
2.67
2.0
2.3
182.60
143.37
nmol/l
—
5
139
245
2021
1.24
2.52
5.1
4.0
0.82
0.83
mmol/l
0.28
237
1924
7
16
4.39
2.47
2.3
1.7
172.09
107.24
ng/l
—
7
16
147
1868
0.77
2.42
1.9
2.5
—
—
—
0
0
48
304
1.59
2.42
4.4
3.9
3.77
4.17
e9/l
0.77
48
304
49
312
1.58
2.42
4.7
4.2
56.29
56.45
%
0.03
49
312
147
1867
0.77
2.41
1.8
2.3
—
—
—
0
0
22
110
2.01
2.41
4.2
3.2
—
—
—
0
0
423
3695
1.18
2.41
2.2
2.2
219.59
381.81
u/l
3.02
411
3506
112
841
1.35
2.38
6.6
4.1
—
—
—
0
0
146
1851
0.77
2.37
1.9
2.5
—
—
—
0
0
79
561
1.42
2.34
1.3
1.3
236.30
184.86
miu/ml
0.55
30
228
400
3491
1.18
2.30
5.0
4.1
11.35
9.09
mg/mmol
0.30
297
2466
376
3265
1.19
2.29
2.8
2.4
—
—
—
0
0
146
1837
0.78
2.24
1.9
2.4
—
—
—
0
0
490
5482
0.86
2.22
3.0
3.5
35.73
38.98
u/l
0.42
465
5211
9
29
3.11
2.22
1.1
1.1
—
—
—
0
0
61
419
1.47
2.17
1.0
1.1
—
—
—
0
0
96
716
1.36
2.15
1.3
1.3
—
—
—
0
0
6
14
4.30
2.15
1.0
1.0
—
—
—
0
0
211
1745
1.23
2.14
1.3
1.2
13.89
8.49
u/ml
0.51
109
783
294
2513
1.20
2.14
2.9
2.4
—
—
—
0
0
64
445
1.45
2.14
1.4
1.3
273.43
236.22
u/ml
0.48
46
290
384
3362
1.17
2.12
7.3
8.3
—
—
—
0
0
93
693
1.36
2.10
5.1
2.8
7.40
7.41
ph
0.13
15
90
197
1621
1.24
2.10
3.2
3.2
2.42
2.42
mmol/l
0.04
182
1434
454
4034
1.16
2.08
4.4
2.8
62.54
59.55
u/l
0.20
432
3803
29
168
1.74
2.08
1.4
1.4
—
—
—
0
0
233
1955
1.22
2.07
1.3
1.2
23.66
24.31
iu/ml
0.04
70
595
183
1498
1.24
2.05
1.7
1.6
1276.62
1123.00
nmol/l
1.62
143
1190
0
57
0.00
2.05
0.0
10.0
—
—
—
0
0
13
56
2.33
2.05
3.3
2.3
—
—
—
0
0
0
58
0.00
2.03
0.0
2.2
—
—
—
0
0
131
1033
1.29
2.01
3.0
3.2
1.67
1.74
%
0.43
115
956
148
1189
1.26
1.96
1.2
1.2
—
—
—
0
0
197
1635
1.23
1.95
1.8
1.4
—
—
—
0
0
0
51
0.00
1.88
0.0
1.8
—
—
—
0
0
36
228
1.59
1.88
1.3
1.3
19.60
34.10
u/l
0.49
30
200
67
484
1.40
1.86
1.5
1.3
190.77
214.15
pmol/l
0.41
67
484
8
28
2.86
1.86
3.7
2.3
—
—
—
0
0
6
17
3.54
1.84
1.2
1.7
—
—
—
0
0
165
1356
1.24
1.81
8.4
10.0
0.97
0.91
mmol/l
0.10
132
1099
19
101
1.89
1.81
1.7
2.1
—
—
—
0
0
43
287
1.51
1.80
8.5
3.9
—
—
—
0
0
571
5211
1.13
1.76
10.8
9.5
1.16
1.18
inr
0.27
180
1638
340
2995
1.16
1.75
3.7
3.0
—
—
—
0
0
6
18
3.34
1.74
1.0
1.1
—
—
—
0
0
16
81
1.98
1.74
1.0
1.0
—
—
—
0
0
16
81
1.98
1.74
1.0
1.0
—
—
—
0
0
40
265
1.52
1.74
1.9
2.4
—
—
—
0
0
30
186
1.62
1.72
1.4
1.4
—
0.33
nmol/l
—
0
13
7
24
2.92
1.72
15.4
5.6
5.16
6.52
mmol/l
—
7
24
76
570
1.35
1.70
2.7
2.4
20.40
21.19
s
1.27
65
492
40
587
0.68
1.70
1.2
1.4
56.25
72.61
titre
—
8
69
17
89
1.92
1.70
4.8
3.5
—
—
—
0
0
0
48
0.00
1.69
0.0
1.2
—
15.52
—
0
42
26
156
1.68
1.69
1.2
1.3
83.15
67.22
mmol/l
0.70
20
119
32
203
1.59
1.68
4.4
2.2
—
—
—
0
0
139
1134
1.24
1.65
1.5
1.3
—
—
—
0
0
111
882
1.27
1.65
1.4
1.4
—
—
—
0
0
80
608
1.33
1.65
3.7
3.4
1.60
1.56
%
0.10
80
603
41
278
1.48
1.62
4.0
2.2
16.18
18.28
%
2.06
24
124
36
238
1.52
1.60
5.8
2.3
8.92
8.60
kpa
0.58
36
232
35
230
1.53
1.60
1.1
1.4
—
—
—
0
0
8
32
2.51
1.59
1.9
2.0
—
—
—
0
0
328
2905
1.15
1.58
1.4
1.4
2.38
2.55
g/l
1.59
264
2066
5
15
3.34
1.52
1.2
1.0
—
—
—
0
0
24
146
1.65
1.51
5.2
2.4
—
—
—
0
0
34
226
1.51
1.49
4.3
2.0
127.00
143.43
g/l
2.78
29
164
39
267
1.47
1.49
4.4
2.6
23.03
24.47
mmol/l
1.62
39
262
790
7406
1.11
1.49
6.4
5.1
6.65
6.76
mmol/l
0.72
759
6991
350
3130
1.14
1.47
8.2
4.6
7.39
7.40
ph
1.19
100
627
15
80
1.88
1.44
1.0
1.0
—
—
—
0
0
95
1183
0.79
1.42
2.0
3.8
—
—
—
0
0
174
1481
1.19
1.39
1.2
1.2
—
—
—
0
0
40
282
1.43
1.34
1.3
1.3
3.70
3.75
u/ml
0.02
23
141
10
47
2.13
1.33
1.9
2.1
10.00
10.32
mmol/l
—
10
47
71
550
1.30
1.33
1.4
2.2
—
—
—
0
0
59
446
1.33
1.31
1.7
1.8
1.32
1.49
g/l
0.91
52
383
17
98
1.74
1.31
1.1
1.2
1553.71
1519.44
miu/ml
0.05
17
98
6
24
2.50
1.30
3.8
2.7
—
—
—
0
0
200
1734
1.17
1.30
3.1
2.5
0.44
0.51
e6/l
0.18
117
893
5
18
2.78
1.28
1.2
1.7
—
—
—
0
0
552
5115
1.11
1.28
7.5
5.5
37.50
37.52
g/l
0.02
532
4812
1594
15541
1.11
1.26
14.4
12.7
337.14
337.18
g/l
0.06
1582
15436
174
1496
1.18
1.26
1.6
1.5
—
—
—
0
0
25
162
1.55
1.26
1.3
1.4
—
—
nmol/l
—
0
0
18
107
1.69
1.26
1.7
1.3
60999.00
63855.77
e6/l
0.02
13
81
26
171
1.53
1.23
1.6
1.4
270.14
340.34
pmol/l
0.56
20
151
27
180
1.51
1.21
5.0
4.8
201.75
175.28
u/ml
0.05
27
168
15
86
1.75
1.19
1.8
1.6
—
—
—
0
0
387
3533
1.12
1.18
4.8
4.4
92.30
91.73
%
0.19
376
3464
31
214
1.46
1.18
2.4
1.9
1.40
1.79
mmol/l
2.29
31
208
26
173
1.51
1.18
1.2
1.3
—
—
—
0
0
131
1108
1.19
1.16
12.3
11.1
—
—
—
0
0
8
39
2.06
1.15
1.0
1.4
—
—
—
0
0
13
72
1.81
1.15
1.1
1.2
—
—
—
0
0
114
953
1.21
1.14
1.3
1.4
—
—
—
0
0
0
36
0.00
1.14
0.0
1.0
—
—
—
0
0
26
175
1.49
1.13
1.1
1.3
—
—
—
0
0
18
111
1.63
1.12
1.9
2.4
33.83
33.19
pg
0.36
18
111
23
151
1.53
1.11
4.8
2.6
1.23
1.28
e9/l
0.11
23
131
86
701
1.24
1.11
1.6
1.4
—
—
—
0
0
406
3735
1.11
1.08
1.3
1.3
—
—
—
0
0
10
181
0.55
1.08
5.9
11.9
0.47
0.57
mmol/l
—
10
166
21
136
1.55
1.08
4.3
2.3
—
—
—
0
0
53
409
1.30
1.07
9.2
7.7
—
—
—
0
0
1377
13376
1.09
1.06
2.8
3.1
46.72
51.25
u/l
1.54
1322
12904
227
2022
1.14
1.05
3.1
3.1
145.34
159.94
ug/g
0.32
193
1763
814
7743
1.08
1.05
2.2
2.3
—
—
—
0
0
7
34
2.06
1.03
1.1
1.2
—
—
—
0
0
17
106
1.61
1.02
1.1
1.2
—
—
—
0
0
110
929
1.19
1.02
1.3
1.2
13.34
53.54
au/ml
—
5
43
304
2766
1.12
1.00
1.4
1.4
—
—
—
0
0
716
6787
1.08
1.00
7.3
7.3
8.82
8.87
%
0.17
688
6515
88
729
1.22
1.00
1.6
2.7
67.48
67.50
g/l
0.01
81
697
37
275
1.35
0.97
1.9
1.6
20202.32
15965.47
e6/l
0.31
28
205
71
578
1.24
0.95
2.5
3.9
4.62
4.77
pmol/l
0.79
65
530
209
1866
1.13
0.95
1.4
1.4
—
—
—
0
0
25
174
1.44
0.95
1.2
1.3
0.34
0.37
g/l
0.22
15
112
25
174
1.44
0.95
1.2
1.3
7.81
6.75
g/l
0.50
15
112
11
62
1.78
0.94
1.0
1.1
—
359.28
—
0
14
51
400
1.28
0.94
1.1
1.1
—
—
—
0
0
25
175
1.43
0.93
1.2
1.3
3.53
3.22
g/l
0.24
15
113
43
330
1.31
0.93
7.9
4.4
2.28
2.20
mmol/l
0.09
35
221
90
757
1.20
0.89
1.3
1.2
—
—
—
0
0
5
102
0.49
0.89
1.2
1.5
—
—
—
0
0
6
29
2.07
0.89
2.2
2.0
78.17
91.71
ug/l
—
6
29
708
6741
1.08
0.87
7.1
7.0
3.03
2.92
%
0.60
678
6472
11
180
0.61
0.86
1.0
1.1
264.64
268.19
mg/l
0.07
11
168
62
507
1.23
0.83
5.6
2.9
—
—
—
0
0
130
1138
1.15
0.82
8.2
4.5
1.66
1.89
mmol/l
0.37
106
974
19
271
0.70
0.80
4.7
2.5
21.79
28.17
mg/l
0.31
14
179
10
164
0.61
0.80
1.6
1.6
12.52
12.66
umol/l
—
10
159
114
991
1.16
0.79
2.3
2.3
35.13
15.41
au/ml
1.19
15
108
62
510
1.22
0.79
2.4
2.0
—
—
—
0
0
217
1973
1.11
0.76
1.5
1.4
17.75
18.43
nmol/l
0.37
192
1777
11
67
1.65
0.75
2.4
1.1
179.73
179.41
mmol/24h
0.00
11
67
16
108
1.49
0.73
1.2
1.6
10.75
29.17
%
—
8
77
44
352
1.26
0.73
1.6
1.6
5189.47
1007.82
e6/l
0.41
38
285
44
352
1.26
0.73
1.5
1.5
34.97
26.49
e6/l
0.13
35
272
6
108
0.55
0.72
2.2
2.9
34.00
50.13
umol/l
—
6
103
151
1351
1.13
0.71
3.9
3.0
33.17
81.19
u/l
0.81
139
1216
419
3942
1.08
0.71
1.7
1.7
96.57
97.35
pmol/l
0.13
259
2222
16
109
1.47
0.71
1.3
1.1
—
—
—
0
0
725
6954
1.07
0.70
6.7
6.8
55.99
56.01
%
0.02
697
6703
5
26
1.93
0.70
3.4
2.0
—
—
—
0
0
22
160
1.38
0.70
2.1
1.2
—
—
—
0
0
18
128
1.41
0.65
1.6
1.6
67.00
55.77
%
0.56
12
91
134
1198
1.13
0.65
2.4
2.5
0.24
0.24
g/l
0.08
126
1105
10
62
1.62
0.65
1.1
1.2
30.80
36.47
mmol/l
—
10
56
5
29
1.73
0.64
1.4
1.4
128.40
118.66
nmol/24h
—
5
29
5
29
1.73
0.64
1.4
1.6
—
—
—
0
0
223
2417
0.91
0.63
3.4
3.3
661.30
619.55
ng/l
0.06
146
1678
47
387
1.22
0.63
1.3
1.4
1265.00
529.81
mg/l
0.48
47
369
103
908
1.14
0.63
2.0
3.1
4.22
5.44
e9/l
0.97
89
802
734
7069
1.06
0.62
7.1
6.9
28.93
29.13
%
0.20
707
6804
33
262
1.26
0.61
1.1
1.1
14.16
12.41
au/ml
—
5
23
99
1118
0.88
0.60
1.2
1.1
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
41
338
1.22
0.56
1.3
1.3
3.77
3.74
mmol/l
0.08
41
317
33
407
0.81
0.56
1.1
1.1
—
—
—
0
0
8
55
1.46
0.56
2.5
1.7
—
—
—
0
0
55
467
1.18
0.56
1.2
1.1
3.83
2.09
u/ml
0.45
27
242
38
312
1.22
0.54
1.2
1.1
26.60
97.11
iu/ml
—
10
84
6
38
1.58
0.54
1.5
1.3
—
—
—
0
0
18
239
0.75
0.54
1.6
3.5
34.18
49.38
mg/l
0.91
13
190
33
267
1.24
0.54
1.2
1.1
—
—
—
0
0
48
567
0.84
0.53
1.5
1.6
—
—
—
0
0
679
6552
1.05
0.53
7.4
7.1
0.70
0.69
%
0.28
649
6286
18
238
0.75
0.53
1.6
3.5
36.07
38.30
mg/l
0.08
12
189
12
83
1.45
0.51
1.8
1.5
7.28
8.23
ug/l
0.16
12
76
18
135
1.34
0.51
3.9
3.2
7.05
8.87
mg/l
0.88
13
111
11
75
1.47
0.50
1.2
1.3
—
—
—
0
0
103
926
1.12
0.49
6.7
2.9
—
—
—
0
0
41
346
1.19
0.46
2.7
2.3
324.38
159.54
ug/min
0.50
34
230
7
48
1.46
0.46
2.0
3.2
—
—
—
0
0
445
4263
1.06
0.46
4.2
3.5
9.35
9.71
mmol/l
0.81
408
3780
7
49
1.43
0.46
1.3
1.7
—
—
—
0
0
82
732
1.13
0.45
5.8
5.3
49.94
14.50
ug/l
0.35
71
601
52
450
1.16
0.45
1.2
1.2
—
—
—
0
0
14
104
1.35
0.43
2.9
3.1
—
—
—
0
0
5
31
1.61
0.43
2.4
2.6
—
59.77
—
0
7
44
509
0.86
0.41
1.3
1.1
—
—
—
0
0
5
33
1.52
0.41
2.2
2.0
19.94
18.91
mg/l
—
5
27
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
11
79
1.39
0.40
1.2
1.1
—
2.16
—
0
18
0
17
0.00
0.40
0.0
9.6
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
5
34
1.47
0.40
1.4
1.4
2.46
1.96
mg/l
—
5
27
5
34
1.47
0.40
1.0
1.1
0.71
9.05
u/ml
—
5
29
0
18
0.00
0.40
0.0
1.2
—
28.56
—
0
18
44
507
0.86
0.40
1.3
1.1
—
—
—
0
0
36
306
1.18
0.39
1.7
1.5
295.35
273.17
ug/g
0.23
21
179
13
97
1.34
0.39
1.2
1.2
—
—
—
0
0
15
115
1.31
0.39
1.1
1.1
—
—
—
0
0
15
115
1.31
0.39
2.1
2.9
1.94
2.38
g/24h
—
8
69
9
69
1.31
0.37
1.9
1.1
147.89
144.80
nmol/l
—
9
69
14
180
0.78
0.37
1.0
1.1
—
—
—
0
0
55
489
1.13
0.35
1.7
1.8
—
—
—
0
0
123
1324
0.92
0.35
1.1
1.1
—
—
—
0
0
16
126
1.27
0.35
3.9
2.6
—
87.46
—
0
18
11
82
1.34
0.34
1.3
1.2
—
—
—
0
0
6
88
0.68
0.33
1.2
1.1
—
—
—
0
0
62
559
1.11
0.32
1.2
1.1
—
—
—
0
0
10
75
1.33
0.30
1.3
2.4
—
27.78
—
0
12
62
681
0.91
0.29
12.6
13.7
—
—
—
0
0
347
3591
0.96
0.28
1.7
1.6
1.47
1.64
mmol/l
2.44
313
3167
11
85
1.30
0.28
1.2
1.1
—
—
—
0
0
131
1234
1.07
0.27
3.0
2.3
9.84
10.71
g/l
2.17
122
1139
54
490
1.10
0.27
2.9
2.6
562.50
458.56
ug/l
0.21
54
468
19
159
1.20
0.26
1.1
1.2
1.45
1.44
g/l
0.10
19
159
68
739
0.92
0.26
4.2
2.8
148.95
145.44
ng/l
0.02
58
628
14
113
1.24
0.26
5.5
2.8
0.25
0.24
e9/l
0.06
14
94
5
72
0.69
0.26
1.2
1.5
560.40
409.88
u/l
—
5
67
23
197
1.17
0.26
1.1
1.1
—
—
—
0
0
68
628
1.09
0.24
1.1
1.1
—
—
—
0
0
153
1604
0.95
0.23
3.6
2.9
6.97
8.66
umol/l
0.74
143
1403
16
189
0.85
0.22
1.3
1.4
—
—
—
0
0
47
429
1.10
0.22
1.1
1.1
10.14
8.93
u/ml
0.10
27
249
14
167
0.84
0.21
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
12
145
0.83
0.21
2.3
3.4
40889.25
44706.90
ug/l
0.27
12
145
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
0.20
—
0
8
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
39
354
1.10
0.21
1.1
1.1
0.88
4.41
u/ml
3.98
17
188
45
412
1.09
0.20
1.1
1.1
0.73
1.92
u/ml
1.17
19
194
9
113
0.80
0.20
2.4
2.4
—
—
—
0
0
14
118
1.19
0.19
5.4
2.8
573.14
590.40
e6/l
0.05
14
97
15
128
1.17
0.18
1.7
1.3
91.20
88.28
umol/l
0.11
15
128
32
290
1.11
0.18
1.1
1.2
—
—
—
0
0
34
310
1.10
0.17
1.3
1.7
0.90
0.92
g/l
0.02
23
235
33
301
1.10
0.17
1.1
1.0
0.85
1.08
u/ml
—
10
84
8
68
1.18
0.16
2.1
1.5
22.21
33.33
umol/l
—
8
62
8
69
1.16
0.16
1.5
1.6
—
—
—
0
0
20
177
1.13
0.16
2.8
3.0
—
—
—
0
0
43
463
0.93
0.16
1.1
1.0
2.79
3.51
u/ml
—
7
78
9
78
1.15
0.15
1.6
2.8
—
—
—
0
0
9
79
1.14
0.15
1.1
1.5
—
—
—
0
0
7
86
0.81
0.14
1.3
1.4
—
73.20
%
—
0
10
41
439
0.93
0.14
2.0
2.2
—
—
—
0
0
8
97
0.82
0.13
2.0
2.9
439.63
1222.96
u/ml
—
8
97
36
335
1.08
0.13
1.1
1.1
2.88
4.26
u/ml
0.43
15
154
9
110
0.82
0.13
2.1
2.2
913.67
702.16
ml
—
9
77
40
426
0.94
0.12
1.1
1.1
—
—
—
0
0
15
168
0.89
0.11
2.3
1.7
—
—
—
0
0
42
396
1.06
0.11
3.5
2.6
—
—
—
0
0
12
105
1.14
0.11
4.1
3.9
62.33
58.99
%
0.28
12
89
17
154
1.10
0.10
1.9
1.9
—
—
—
0
0
5
44
1.14
0.10
1.6
1.4
—
—
—
0
0
28
299
0.94
0.09
1.1
1.0
3.42
2.58
u/ml
0.26
17
175
7
64
1.09
0.08
1.1
1.1
—
—
—
0
0
186
1893
0.98
0.08
1.3
1.3
358.52
311.94
titre
0.24
27
253
6
70
0.86
0.07
1.5
1.5
—
—
—
0
0
8
74
1.08
0.07
1.3
1.7
—
—
—
0
0
8
75
1.07
0.07
1.4
1.1
412.13
408.71
nmol/l
—
8
69
33
347
0.95
0.07
3.7
3.4
38.48
37.21
umol/l
0.11
33
329
9
85
1.06
0.07
2.0
2.3
518.11
499.55
min
—
9
67
9
86
1.05
0.07
1.0
1.3
—
—
—
0
0
43
413
1.04
0.06
5.1
4.0
1.04
0.28
g/l
0.46
27
269
34
356
0.95
0.06
9.7
2.9
1.00
0.85
nmol/l
0.70
29
316
228
2250
1.01
0.06
1.5
1.4
—
—
—
0
0
33
345
0.96
0.06
3.0
2.8
—
—
—
0
0
17
182
0.93
0.05
1.5
3.6
—
—
—
0
0
14
129
1.09
0.05
1.4
1.3
—
—
—
0
0
364
3671
0.99
0.05
1.3
1.3
—
—
—
0
0
12
110
1.09
0.05
1.0
1.0
—
—
—
0
0
19
181
1.05
0.03
1.6
1.5
—
—
—
0
0
11
102
1.08
0.03
1.2
1.1
223.59
219.51
iu/ml
0.03
11
102
11
118
0.93
0.02
1.3
1.4
—
—
—
0
0
34
332
1.02
0.01
1.8
1.5
—
—
—
0
0
12
127
0.94
0.01
1.0
1.0
0.15
9.02
u/ml
—
5
32
32
327
0.98
0.01
4.7
3.4
—
—
—
0
0
21
204
1.03
0.00
1.7
1.6
—
—
—
0
0
13
135
0.96
0.00
1.0
1.0
0.67
3.63
u/ml
—
5
28
11
109
1.01
0.00
1.0
1.1
—
—
—
0
0
12
119
1.01
0.00
3.3
4.4
—
—
—
0
0
14
141
0.99
0.00
3.2
2.8
11.57
11.85
%
0.11
14
141
22
219
1.00
0.00
1.4
1.8
4.04
4.12
iu/l
—
8
74
18
176
1.02
0.00
2.8
1.8
—
—
—
0
0
12
118
1.02
0.00
1.1
1.2
—
—
—
0
0
14
143
0.98
0.00
3.4
2.4
43.33
41.40
%
—
9
60
16
157
1.02
0.00
1.4
1.7
—
—
—
0
0
42
423
0.99
0.00
1.1
1.1
0.70
3.17
u/ml
3.04
20
214
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
5
49
1.02
0.00
2.8
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
2.9
—
—
—
0
0
7
76
0.92
0.00
1.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
5.68
—
0
9
5
49
1.02
0.00
2.8
1.3
—
—
—
0
0
5
49
1.02
0.00
2.6
1.3
—
—
—
0
0
14
140
1.00
-0.00
1.4
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
69
0.87
-0.00
4.2
2.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.6
—
—
—
0
0
8
85
0.94
-0.00
2.3
2.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
6
64
0.94
-0.00
4.7
7.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
7.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
9587.71
—
0
7

Mortality – FinRegistry

Association

Association between endpoint N14_MALEINFERT and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
N14_MALEINFERT 0.764 [0.66, 0.88] < 0.001
Birth year 0.987 [0.98, 1.0] 0.008

During the follow-up period (1.1.1998 — 31.12.2019), 310 out of 16070 males with N14_MALEINFERT died.

Mortality risk

Mortality risk for people of age

years, who have N14_MALEINFERT.

N-year risk Females Males
1 No data 0.133%
5 No data 0.87%
10 No data 2.112%
15 No data 4.228%
20 No data 7.232%

Relationships between endpoints

Index endpoint: N14_MALEINFERT – Male infertility

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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