No definition available.
Viral encephalitis, not elsewhere classified/unspecified
AB1_VIRAL_ENCEPHALITIS_NOS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
730 |
4. Check minimum number of eventsNone |
730 |
5. Include endpointsNone |
730 |
6. Filter based on genotype QC (FinnGen only) |
730 |
Control definitions (FinnGen only)
- Control exclude
- AB1_VIRAL_CNS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Viral encephalitis, not elsewhere classified/unspecified
based on the number of shared cases.
Similar with more cases:
- Viral infections of the central nervous system
- Certain infectious and parasitic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6491 | 3070 | 3393 |
| Only index persons | 5729 | 2699 | 3030 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.09 | 0.09 |
| Only index persons | 0.11 | 0.10 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 52.94 | 56.53 | 49.53 |
| Only index persons | 52.07 | 55.63 | 48.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 730 | 370 | 360 |
| Unadjusted period prevalence (%) | 0.14 | 0.13 | 0.16 |
| Median age at first event (years) | 56.60 | 53.49 | 59.79 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 668
- Matched controls
- 6678
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A86
ICD-10 Finland
Unspecified viral encephalitis
+∞
323.0
619
*
TAB00
NOMESCO Finland
Lumbar puncture
20.9
125.1
193
127
AA1AD
NOMESCO Finland
CT of head and brain
5.1
74.5
306
949
A87.9
ICD-10 Finland
Viral meningitis, unspecified
369.5
66.8
66
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
7.2
57.3
152
263
XA800
NOMESCO Finland
Neuropsychological investigation
12.5
55.9
104
97
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
9.9
54.8
116
139
R56.8
ICD-10 Finland
Other and unspecified convulsions
9.6
53.4
115
142
R41.0
ICD-10 Finland
Disorientation, unspecified
12.8
50.8
93
83
G04.9
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis, unspecified
69.0
50.1
57
9
N03AX14
ATC
levetiracetam; systemic
15.2
47.9
81
60
G40.9
ICD-10 Finland
Epilepsy, unspecified
11.9
44.4
84
80
5AB01
NOMESCO Finland
NA
218.0
40.3
41
*
G05.1*B00.4
ICD-10 Finland
Herpesviral meningoencephalitis
376.7
36.3
36
*
A85.8
ICD-10 Finland
Other specified viral encephalitis
+∞
35.7
34
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.8
34.5
170
553
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
14.7
34.2
58
43
N03AF02
ATC
oxcarbazepine; oral
9.7
32.7
68
77
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
15.4
32.5
54
38
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
9.4
31.2
66
77
XF400
NOMESCO Finland
ECG with 12 standard connections
3.4
29.5
167
596
R50.9
ICD-10 Finland
Fever, unspecified
3.6
29.1
152
511
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.4
28.2
111
290
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
14.3
28.2
48
36
F05.9
ICD-10 Finland
Delirium, unspecified
11.2
25.7
49
47
XA400
NOMESCO Finland
EEG
26.1
21.9
30
12
N03AG01
ATC
valproic acid; systemic, rectal
4.7
21.8
78
184
R51.80
ICD-10 Finland
Headache
3.0
21.3
142
558
G41.9
ICD-10 Finland
Status epilepticus, unspecified
29.1
21.1
28
10
ZX120
NOMESCO Finland
Intravenous
3.6
20.2
99
311
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
28.1
20.2
27
10
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.2
20.1
113
394
B94.1
ICD-10 Finland
Sequelae of viral encephalitis
+∞
19.9
19
*
N03AX18
ATC
lacosamide; systemic
25.5
19.7
27
11
G03.9
ICD-10 Finland
Meningitis, unspecified
108.3
19.7
21
*
R4120
NOMESCO Finland
Occupational therapy
4.3
19.6
76
194
183
Kela drug reimbursment
Lamotrigin and topiramate
21.6
18.7
27
13
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.7
18.7
141
596
N03AB02
ATC
phenytoin; systemic
14.9
18.2
30
21
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.4
18.1
192
973
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.6
17.6
83
252
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
16.9
164
792
G05.1*A85.0
ICD-10 Finland
Encephalitis, myelitis or encephalomyelitis (in) enteroviral
+∞
16.7
16
*
R4150
NOMESCO Finland
Neuropsychological rehabilitation
20.7
16.5
24
12
N71
ICPC
Meningitis/encephalitis
+∞
15.7
15
*
WX892
NOMESCO Finland
Monitored bed care
3.4
15.3
78
252
A41.9
ICD-10 Finland
Sepsis, unspecified
5.3
15.0
46
92
G05.1
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis in viral diseases classified elsewhere
+∞
14.6
14
*
A84.8
ICD-10 Finland
Other tick-borne viral encephalitis
+∞
14.6
14
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
14.1
296
1960
A84.9
ICD-10 Finland
Tick-borne viral encephalitis, unspecified
+∞
13.6
13
*
B00.4
ICD-10 Finland
Herpesviral encephalitis
142.8
13.5
14
*
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
15.4
13.2
21
14
N05BA09
ATC
clobazam; oral
17.1
13.0
20
12
N03AF01
ATC
carbamazepine; oral, rectal
4.2
13.0
50
127
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.6
13.0
100
422
J05AB11
ATC
valaciclovir; oral
2.5
12.8
104
453
TKC20
NOMESCO Finland
Catheterisation of bladder
3.1
12.6
72
253
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
13.5
12.5
21
16
G41.0
ICD-10 Finland
Grand mal status epilepticus
47.6
11.9
14
*
5CM18
NOMESCO Finland
NA
30.6
11.7
15
5
R53
ICD-10 Finland
Malaise and fatigue
2.1
11.2
151
827
R47.0
ICD-10 Finland
Dysphasia and aphasia
10.3
11.1
21
21
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
5.4
10.9
32
62
R42
ICD-10 Finland
Dizziness and giddiness
2.0
10.9
150
830
J01DB01
ATC
cefalexin; oral
1.9
10.7
529
4467
R11
ICD-10 Finland
Nausea and vomiting
3.0
10.6
64
231
N05AH04
ATC
quetiapine; oral
2.2
10.5
122
628
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
10.3
116
590
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
6.4
10.2
26
42
F05.8
ICD-10 Finland
Other delirium
13.4
10.2
17
13
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.9
10.2
62
225
WX730
NOMESCO Finland
Conventional respirator
7.1
10.2
24
35
N03AE01
ATC
clonazepam; systemic
3.4
10.1
48
148
N05BA01
ATC
diazepam; systemic, rectal
2.3
10.0
101
488
G40.21
ICD-10 Finland
Partial epileptic seizure with cloudiness and automatism
20.4
9.8
14
7
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.6
9.7
71
290
N03AX16
ATC
pregabalin; oral
1.9
9.7
154
898
G40
ICD-10 Finland
Epilepsy
13.6
9.7
16
12
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.7
9.6
289
2068
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.3
9.5
92
436
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.4
9.5
79
347
R4110
NOMESCO Finland
Physiotherapy
1.8
9.5
179
1110
G02.0*B00.3
ICD-10 Finland
Herpesviral meningitis
+∞
9.4
9
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.0
9.3
123
666
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.8
9.1
58
220
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.4
8.8
74
324
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
2.6
8.7
62
250
G04.8
ICD-10 Finland
Other encephalitis, myelitis and encephalomyelitis
27.9
8.5
11
*
G40.89
ICD-10 Finland
Other epilepsy
91.2
8.4
9
*
G09
ICD-10 Finland
Sequelae of inflammatory diseases of central nervous system
91.2
8.4
9
*
G01*A69.2
ICD-10 Finland
Meningitis (in) Lyme disease
91.2
8.4
9
*
H02AB06
ATC
prednisolone; systemic
1.6
8.4
292
2150
F07.1
ICD-10 Finland
Postencephalitic syndrome
+∞
8.3
8
*
A87.8
ICD-10 Finland
Other viral meningitis
+∞
8.3
8
*
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.1
8.3
100
522
N06AX11
ATC
mirtazapine; oral
1.7
8.2
198
1317
N03AX09
ATC
lamotrigine; oral
3.2
8.1
42
139
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
2.8
8.1
51
191
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
7.4
8.0
18
25
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.4
8.0
66
287
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
7.9
220
1519
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.2
7.8
40
132
L28
ICPC
Limited function/disability (L)
2.0
7.8
106
581
R1260
NOMESCO Finland
Evaluation of communicative skills
5.7
7.7
21
38
N30.0
ICD-10 Finland
Acute cystitis
2.0
7.7
96
508
C03CA01
ATC
furosemide; systemic
1.7
7.7
185
1224
J01MA12
ATC
levofloxacin; systemic
1.9
7.6
121
699
A69.2
ICD-10 Finland
Lyme disease
3.2
7.6
38
123
A28
ICPC
Limited function/disability NOS
2.0
7.6
101
546
G40.11
ICD-10 Finland
Simple partial epileptic seizure that develops into a complex partial seizure
80.9
7.4
8
*
N06AB10
ATC
escitalopram; oral
1.8
7.4
124
733
N05CF01
ATC
zopiclone; oral
1.6
7.1
202
1396
C07AB07
ATC
bisoprolol; oral
1.6
7.1
279
2095
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.2
7.0
66
311
N02AA05
ATC
oxycodone; systemic
2.0
6.9
94
516
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
6.8
179
1207
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
5.1
6.8
20
40
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.8
6.8
113
666
R4130
NOMESCO Finland
Speech therapy
4.4
6.8
23
54
N03AX23
ATC
brivaracetam; systemic
40.5
6.8
8
*
G93.4
ICD-10 Finland
Encephalopathy, unspecified
40.5
6.8
8
*
G41.2
ICD-10 Finland
Complex partial status epilepticus
40.5
6.8
8
*
B02.0
ICD-10 Finland
Zoster encephalitis
40.5
6.8
8
*
N06AB04
ATC
citalopram; systemic
1.7
6.8
138
868
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
5.3
6.7
19
37
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
5.6
6.6
18
33
N05AA02
ATC
levomepromazine; systemic
3.2
6.6
33
108
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
4.8
6.4
20
43
G00.9
ICD-10 Finland
Bacterial meningitis, unspecified
70.5
6.4
7
*
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
6.6
6.4
15
23
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
6.3
187
1303
JN4BD
NOMESCO Finland
Extensive body CT
2.1
6.3
72
369
G05.1*B02.0
ICD-10 Finland
Zoster encephalitis
+∞
6.3
6
*
F02.89*G40.9
ICD-10 Finland
Dementia in epilepsy
26.9
6.2
8
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.4
6.2
48
205
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.3
6.2
56
259
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.0
6.2
81
438
N29
ICPC
Neurological sympt/complt other
4.1
6.1
22
55
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.4
6.1
49
211
A02BC02
ATC
pantoprazole; systemic
1.5
6.1
389
3218
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.8
6.1
105
625
Mortality – FinRegistry
↥Association
Association between endpoint AB1_VIRAL_ENCEPHALITIS_NOS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_VIRAL_ENCEPHALITIS_NOS | 2.464 [2.09, 2.9] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.08 |
During the follow-up period (1.1.1998 — 31.12.2019), 682 out of 2632 females with AB1_VIRAL_ENCEPHALITIS_NOS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_VIRAL_ENCEPHALITIS_NOS | 2.368 [2.0, 2.8] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.027 |
During the follow-up period (1.1.1998 — 31.12.2019), 697 out of 2910 males with AB1_VIRAL_ENCEPHALITIS_NOS died.
Mortality risk
Mortality risk for people of age
years, who have AB1_VIRAL_ENCEPHALITIS_NOS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.192% | 0.38% |
| 5 | 1.417% | 2.691% |
| 10 | 3.442% | 7.213% |
| 15 | 6.084% | 13.363% |
| 20 | 10.659% | 21.966% |
Relationships between endpoints
↥Index endpoint: AB1_VIRAL_ENCEPHALITIS_NOS – Viral encephalitis, not elsewhere classified/unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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