No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
809 |
4. Check minimum number of eventsNone |
809 |
5. Include endpointsNone |
809 |
6. Filter based on genotype QC (FinnGen only) |
809 |
Control definitions (FinnGen only)
- Control exclude
- E4_NUTRIDEF
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E61
- Name in latin
- Sideropenia
Similar endpoints
↥List of similar endpoints to
Iron deficiency
based on the number of shared cases.
Similar with more cases:
- Other nutritional deficiencies
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3324 | 2703 | 601 |
| Only index persons | 2876 | 2502 | 374 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.08 | 0.02 |
| Only index persons | 0.08 | 0.09 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 33.31 | 36.44 | 19.09 |
| Only index persons | 40.25 | 37.72 | 57.20 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 809 | 713 | 96 |
| Unadjusted period prevalence (%) | 0.22 | 0.24 | 0.04 |
| Median age at first event (years) | 41.57 | 38.36 | 65.41 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 623
- Matched controls
- 6228
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E61.1
ICD-10 Finland
Iron deficiency
+∞
323.0
623
73
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
11.7
83.1
165
186
E66.8
ICD-10 Finland
Other obesity
59.3
54.9
64
12
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.4
52.0
238
774
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
+∞
48.6
46
*
E66.01
ICD-10 Finland
Obesity due to excess calories
17.8
44.2
70
44
R53
ICD-10 Finland
Malaise and fatigue
3.5
36.8
215
817
D64.9
ICD-10 Finland
Anaemia, unspecified
5.5
24.7
77
157
UJF32
NOMESCO Finland
Coloscopy
3.1
24.4
158
619
B03BA03
ATC
hydroxocobalamin; parenteral
7.8
24.3
57
79
D50.8
ICD-10 Finland
Other iron deficiency anaemias
15.3
23.7
39
27
E66.00
ICD-10 Finland
Metabolic syndrome
25.8
23.3
32
13
UJF30
NOMESCO Finland
Ileoscopy through colon
3.9
19.6
86
247
B02AA02
ATC
tranexamic acid; systemic
2.8
19.5
141
583
UJF92
NOMESCO Finland
Capsular endoscopy
9.0
18.9
40
47
E66.9
ICD-10 Finland
Obesity, unspecified
28.9
18.9
25
9
D50
ICD-10 Finland
Iron deficiency anaemia
7.7
18.8
44
61
N92.0
ICD-10 Finland
Excessive and frequent menstruation with regular cycle
2.9
17.4
114
441
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
15.7
217
1238
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.3
15.2
159
795
B81
ICPC
Anaemia vit B12/folate deficiency
9.8
15.1
30
32
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
7.6
14.7
34
47
A02BC02
ATC
pantoprazole; systemic
2.0
14.6
357
2533
G47.3
ICD-10 Finland
Sleep apnoea
3.0
14.5
91
340
A02BC05
ATC
esomeprazole; systemic
2.0
14.2
236
1441
ZX120
NOMESCO Finland
Intravenous
3.3
14.0
73
241
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.3
13.8
71
232
E66.2
ICD-10 Finland
Extreme obesity with alveolar hypoventilation
143.0
13.5
14
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.9
12.8
263
1724
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
4.2
12.2
47
120
A10BA02
ATC
metformin; oral
2.5
12.2
103
460
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
4.3
11.8
44
109
N02AJ06
ATC
codeine and paracetamol; systemic
1.9
11.8
230
1469
R01AD12
ATC
fluticasone furoate; nasal
1.9
11.7
239
1553
WVA20
NOMESCO Finland
Medicine administration
7.7
11.5
26
35
WX002
NOMESCO Finland
Sedation and analgesia
2.4
11.4
108
510
TPH04
NOMESCO Finland
Cathetrisation of vein
2.3
11.4
117
575
SPAT1262
SPAT
Handing over of treatment supplies
2.5
11.3
90
389
QBJ30
NOMESCO Finland
Correction of abdominal apron
20.5
11.2
16
8
N02AX02
ATC
tramadol; systemic, rectal
1.9
11.1
202
1251
B80
ICPC
Iron deficiency anaemia
5.7
11.0
31
57
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
3.0
11.0
64
228
R06.0
ICD-10 Finland
Dyspnoea
2.1
10.7
128
670
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
3.1
10.6
57
193
3AC01
NOMESCO Finland
NA
9.4
10.6
21
23
A04
ICPC
Weakness/tiredness general
2.2
10.5
111
551
R03AC02
ATC
salbutamol; inhalant
1.7
10.3
343
2571
H02AB06
ATC
prednisolone; systemic
1.8
10.2
258
1777
N06AX16
ATC
venlafaxine; oral
2.2
10.1
106
525
O99.0
ICD-10 Finland
Anaemia complicating pregnancy, childbirth and the puerperium
5.8
9.9
27
48
H03AA01
ATC
levothyroxine sodium; systemic
2.0
9.8
152
882
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.3
9.8
91
425
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
2.1
9.6
113
585
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
9.1
128
711
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.6
9.0
67
279
N06AX12
ATC
bupropion; oral
2.7
8.8
59
230
J45
ICD-10 Finland
Asthma
2.4
8.7
73
322
103
Kela drug reimbursment
Diabetes, insulin-treated
2.2
8.7
92
455
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.4
8.4
74
333
R03BB04
ATC
tiotropium bromide; inhalant
3.1
8.3
44
148
N05BA04
ATC
oxazepam; oral
1.8
8.3
152
932
N04BC05
ATC
pramipexole; oral
3.4
8.2
38
116
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.7
8.2
242
1715
R4190
NOMESCO Finland
Nutritional therapy
4.6
8.1
27
61
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.7
8.0
193
1287
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
13.2
7.9
13
10
N06AX26
ATC
vortioxetine; oral
2.7
7.9
54
215
N06AX11
ATC
mirtazapine; oral
1.7
7.8
184
1219
M03BX02
ATC
tizanidine; oral
1.6
7.7
355
2811
WX402
NOMESCO Finland
General anaesthesia
2.0
7.7
104
570
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
2.3
7.6
72
338
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.1
7.6
87
443
SPAT1310
SPAT
Counselling related to known health issue
1.7
7.6
206
1420
A06AC01
ATC
ispaghula (psylla seeds); oral
1.9
7.5
121
705
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.6
7.4
348
2760
A02BC01
ATC
omeprazole; systemic
1.8
7.4
149
939
SPAT1263
SPAT
Sampling
1.6
7.4
280
2104
G25.8
ICD-10 Finland
Other specified extrapyramidal and movement disorders
5.5
7.3
20
37
A07EA06
ATC
budesonide; oral, local oral
3.4
7.2
33
101
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
1.9
7.1
110
633
T82
ICPC
Obesity
4.2
7.1
25
61
SPAT1301
SPAT
No procedures
1.7
7.1
196
1350
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.6
7.0
50
204
I10
ICD-10 Finland
Essential (primary) hypertension
1.7
7.0
170
1126
M54.5
ICD-10 Finland
Low back pain
1.7
7.0
198
1371
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.1
6.9
83
434
I50.9
ICD-10 Finland
Heart failure, unspecified
3.0
6.9
37
127
SPAT1139
SPAT
Nutrition survey
4.5
6.9
23
53
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.4
6.9
55
239
J45.9
ICD-10 Finland
Asthma, unspecified
1.9
6.8
102
578
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
2.0
6.7
93
514
T90
ICPC
Diabetes non-insulin dependent
2.1
6.6
70
347
E11
ICD-10 Finland
Type 2 diabetes mellitus
2.5
6.6
50
212
N05CF01
ATC
zopiclone; oral
1.7
6.6
143
918
A02BC04
ATC
rabeprazole; oral
2.4
6.5
54
238
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.7
6.5
145
938
R42
ICD-10 Finland
Dizziness and giddiness
1.9
6.4
104
606
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.9
6.4
99
569
J01AA02
ATC
doxycycline; systemic
1.6
6.4
415
3500
C03CA01
ATC
furosemide; systemic
2.1
6.4
76
394
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
3.7
6.4
26
73
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
1.9
6.3
89
494
Z01.7
ICD-10 Finland
Laboratory examination
2.1
6.3
68
342
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.3
6.3
58
270
E66.0
ICD-10 Finland
Obesity due to excess calories
+∞
6.3
6
*
A10BH01
ATC
sitagliptin; oral
3.1
6.2
31
102
UJD02
NOMESCO Finland
Gastroscopy
3.6
6.2
26
75
D64.8
ICD-10 Finland
Other specified anaemias
7.8
6.1
13
17
OAB72
NOMESCO Finland
Weight control and weight loss guidance
12.7
6.1
10
8
B01AB05
ATC
enoxaparin; parenteral
1.7
6.1
124
780
K30
ICD-10 Finland
Functional dyspepsia
2.1
6.1
66
331
N06AB04
ATC
citalopram; systemic
1.8
6.1
119
739
XW000
NOMESCO Finland
Bone marrow biopsy
4.0
6.0
22
56
A10BH05
ATC
linagliptin; oral
5.6
6.0
16
29
SPAT1249
SPAT
Treatment-related counselling outside office
1.5
6.0
267
2050
Mortality – FinRegistry
↥Association
Association between endpoint E4_FE_DEF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_FE_DEF | 2.095 [1.24, 3.53] | 0.006 |
| Birth year | 0.991 [0.98, 1.0] | 0.05 |
During the follow-up period (1.1.1998 — 31.12.2019), 86 out of 757 females with E4_FE_DEF died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have E4_FE_DEF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.187% | No data |
| 5 | 1.011% | No data |
| 10 | 2.722% | No data |
| 15 | 5.249% | No data |
| 20 | 9.096% | No data |
Relationships between endpoints
↥Index endpoint: E4_FE_DEF – Iron deficiency
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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