No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
772 |
4. Check minimum number of eventsNone |
772 |
5. Include endpointsNone |
772 |
6. Filter based on genotype QC (FinnGen only) |
772 |
Control definitions (FinnGen only)
- Control exclude
- H7_LIDLACRIMALORBIT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H04
- Name in latin
- Epiphora
Similar endpoints
↥List of similar endpoints to
Epiphora
based on the number of shared cases.
Similar with more cases:
- Disorders of lacrimal system
- Disorders of eyelid, lacrimal system and orbit
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5034 | 3324 | 1700 |
| Only index persons | 4691 | 3161 | 1530 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.10 | 0.05 |
| Only index persons | 0.10 | 0.12 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 58.49 | 57.92 | 59.66 |
| Only index persons | 58.69 | 58.09 | 59.95 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 772 | 548 | 224 |
| Unadjusted period prevalence (%) | 0.16 | 0.19 | 0.10 |
| Median age at first event (years) | 61.15 | 59.76 | 64.56 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 670
- Matched controls
- 6697
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H04.2
ICD-10 Finland
Epiphora
4503599627370496.0
323.0
662
*
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
3863.0
292.9
261
*
XCC00
NOMESCO Finland
Investigative irrigation of lacrimal passages
739.1
222.0
207
*
TCC10
NOMESCO Finland
Probing of lacrimal canaliculus/duct
1240.6
110.8
105
*
TCC30
NOMESCO Finland
Intubation of lacrimal canaliculus/duct
1226.6
109.7
104
*
H04.10
ICD-10 Finland
Dry eye syndrome
14.4
86.1
153
135
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
4.7
75.8
399
1606
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
4.2
66.9
431
2005
CCA20
NOMESCO Finland
Incision of lacrimal punctum or canaliculus
+∞
56.0
53
*
H02.3
ICD-10 Finland
Blepharochalasis
41.8
54.7
68
18
S01GX01
ATC
cromoglicic acid; ophthalmic
3.8
43.1
223
775
CCD60
NOMESCO Finland
Transnasal dacryocystorhinostomy
152.8
41.3
43
*
H02.1
ICD-10 Finland
Ectropion of eyelid
343.1
33.2
33
*
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
+∞
29.4
28
*
CCD50
NOMESCO Finland
Dacryocystorhinostomy with insertion of tube
+∞
28.3
27
*
H02.4
ICD-10 Finland
Ptosis of eyelid
40.9
28.3
35
9
UDH02
NOMESCO Finland
Rhinopharyngoscopy
4.5
22.4
83
203
H04.4
ICD-10 Finland
Chronic inflammation of lacrimal passages
+∞
22.0
21
*
CBB10
NOMESCO Finland
Excision of redundant skin of eyelid
64.8
22.0
25
*
H04.3
ICD-10 Finland
Acute and unspecified inflammation of lacrimal passages
82.9
21.8
24
*
CBB11
NOMESCO Finland
Resection of lax skin in upper eyelid
227.0
21.7
22
*
F03
ICPC
Eye discharge
4.9
21.7
74
166
ZXA10
NOMESCO Finland
Bilateral
2.7
21.1
173
772
R01AD09
ATC
mometasone; nasal
2.2
20.6
335
2102
WX002
NOMESCO Finland
Sedation and analgesia
2.6
20.1
176
810
H01.0
ICD-10 Finland
Blepharitis
6.0
19.6
55
98
WX110
NOMESCO Finland
Local anesthesy
2.2
19.1
473
3513
CBB20
NOMESCO Finland
Correction of lax skin of eyelid and resection of herniated fat
97.7
17.6
19
*
CCD30
NOMESCO Finland
Reconstruction of lacrimal canaliculus
+∞
16.7
16
*
CBN30
NOMESCO Finland
Shortening of canthal ligament
+∞
16.7
16
*
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
4.1
14.6
57
147
F29
ICPC
Eye symptom/complaint other
3.3
14.3
75
247
R07.4
ICD-10 Finland
Chest pain, unspecified
2.1
14.2
204
1165
J01CA04
ATC
amoxicillin; systemic
2.1
13.6
541
4478
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
2.2
13.4
151
775
L17
ICPC
Foot/toe symptom/complaint
2.1
13.4
195
1116
A06AC01
ATC
ispaghula (psylla seeds); oral
2.1
13.2
191
1089
H10.5
ICD-10 Finland
Blepharoconjunctivitis
9.9
12.3
24
25
J01DB01
ATC
cefalexin; oral
2.0
12.0
541
4543
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
3.7
12.0
52
148
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
11.9
211
1295
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.3
11.6
121
596
A02BC05
ATC
esomeprazole; systemic
1.8
11.5
292
2016
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
11.5
241
1561
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.1
11.5
155
854
R01AD08
ATC
fluticasone; nasal
1.9
11.4
195
1178
S18
ICPC
Laceration/cut
1.8
11.3
295
2052
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.8
11.2
311
2204
S01GX08
ATC
ketotifen; ophthalmic
4.9
11.0
35
74
H02AB06
ATC
prednisolone; systemic
1.7
10.9
311
2219
SPAT1153
SPAT
Removal of sutures
1.8
10.9
232
1508
SAA02
NOMESCO Finland
Basic examination of mouth
1.7
10.9
409
3172
H10.4
ICD-10 Finland
Chronic conjunctivitis
18.2
10.8
16
9
UDM02
NOMESCO Finland
Sinoscopy
6.7
10.6
26
40
CCD40
NOMESCO Finland
Percutaneous dacryocystorhinostomy
+∞
10.4
10
*
ZXA00
NOMESCO Finland
Right side
1.9
10.3
197
1229
J01AA02
ATC
doxycycline; systemic
1.8
9.9
520
4394
N02BE01
ATC
paracetamol; systemic, rectal
2.0
9.9
581
5111
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.7
9.8
354
2671
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.6
9.8
72
296
D07AB02
ATC
hydrocortisone butyrate; topical
1.8
9.5
194
1231
CBB30
NOMESCO Finland
Excision of lesion of eyelid
4.9
9.4
30
64
H01.80
ICD-10 Finland
Prolonged inflammation in the edge of the eyelid
101.4
9.4
10
*
H04.0
ICD-10 Finland
Dacryoadenitis
+∞
9.4
9
*
TCC40
NOMESCO Finland
Closure of lacrimal canaliculus with plug
+∞
9.4
9
*
M03BX02
ATC
tizanidine; oral
1.7
9.3
400
3152
L03
ICPC
Low back symptom/complaint
1.9
9.3
170
1039
ZXA05
NOMESCO Finland
Left side
1.8
9.3
182
1141
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
6.9
9.2
22
33
H00.1
ICD-10 Finland
Chalazion
6.0
9.1
24
41
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
3.3
9.0
44
139
A02BC03
ATC
lansoprazole; oral
1.7
8.9
207
1365
SAA03
NOMESCO Finland
Extended examination of mouth
1.7
8.9
243
1683
H10.1
ICD-10 Finland
Acute atopic conjunctivitis
5.0
8.8
27
56
E000001
ATC
NA
1.9
8.7
140
817
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.5
8.6
67
284
E0000UV
ATC
NA
1.7
8.5
269
1935
H53.1
ICD-10 Finland
Subjective visual disturbances
2.9
8.4
52
192
ZXE00
NOMESCO Finland
One hour or less
1.6
8.4
268
1930
3752A
ICD-9 Finland
Disorders of lachrymal system, Epiphora
+∞
8.3
8
*
CBN99
NOMESCO Finland
Other operation on eyelid for malposition
+∞
8.3
8
*
CBF10
NOMESCO Finland
Shortening of canthal ligaments and tarsal plate for ectropion
+∞
8.3
8
*
CCC99
NOMESCO Finland
Other operation on lacrimal passages
+∞
8.3
8
*
CBJ40
NOMESCO Finland
Resection of levator muscle of eyelid
+∞
8.3
8
*
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.6
8.2
330
2523
H10
ICD-10 Finland
Conjunctivitis
2.9
8.2
48
173
S01GX09
ATC
olopatadine; ophthalmic
4.6
8.1
27
61
H02AB07
ATC
prednisone; oral
2.0
8.0
106
572
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.1
8.0
88
441
M19.0
ICD-10 Finland
Primary arthrosis of other joints
2.3
8.0
75
351
SAA01
NOMESCO Finland
Simple examination of mouth
1.6
8.0
438
3609
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
7.9
263
1907
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.6
7.9
250
1789
R13
ICD-10 Finland
Dysphagia
2.6
7.8
54
216
R03AC02
ATC
salbutamol; inhalant
1.6
7.7
333
2576
UJF32
NOMESCO Finland
Coloscopy
1.7
7.6
172
1115
SPAT1260
SPAT
Consultation of another employee
1.9
7.6
129
764
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
7.4
319
2457
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
7.4
279
2080
H25.1
ICD-10 Finland
Senile nuclear cataract
1.7
7.4
174
1144
A02BC02
ATC
pantoprazole; systemic
1.6
7.3
422
3480
CBJ50
NOMESCO Finland
Operation for ptosis of eyebrow
+∞
7.3
7
*
CBB00
NOMESCO Finland
Excision of chalazion
+∞
7.3
7
*
R09.1
ICD-10 Finland
Pleurisy
6.3
7.3
18
29
R01BA52
ATC
pseudoephedrine, combinations; oral
1.6
7.2
203
1400
SDA02
NOMESCO Finland
Parodonthologic therapy
1.6
7.1
210
1467
R06AX13
ATC
loratadine; oral
1.9
7.1
101
560
R03DC03
ATC
montelukast; oral
1.9
7.0
115
673
L01
ICPC
Neck symptom/complaint
2.0
7.0
97
533
J01FA10
ATC
azithromycin; systemic
1.5
7.0
357
2846
D23.1
ICD-10 Finland
Benign neoplasm: Skin of eyelid, including canthus
3.6
7.0
30
87
R06AX26
ATC
fexofenadine; oral
2.6
6.9
48
191
ZXD20
NOMESCO Finland
Day surgery
2.0
6.9
92
497
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.0
6.9
92
497
J01MA02
ATC
ciprofloxacin; systemic
1.6
6.9
239
1736
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.0
6.8
94
517
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
6.8
179
1207
S29
ICPC
Skin symptom/complaint other
1.9
6.7
110
642
H02.2
ICD-10 Finland
Lagophthalmos
22.8
6.7
9
*
SPAT1301
SPAT
No procedures
1.6
6.7
218
1559
D07AC01
ATC
betamethasone; topical
1.6
6.6
219
1566
J01FA06
ATC
roxithromycin; oral
1.6
6.6
257
1912
K02.1
ICD-10 Finland
Caries of dentine
1.5
6.6
336
2661
G44.2
ICD-10 Finland
Tension-type headache
1.9
6.6
92
507
S21
ICPC
Skin texture symptom/complaint
2.0
6.6
84
445
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.5
6.6
274
2074
M01AH05
ATC
etoricoxib; oral
1.5
6.6
364
2940
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.2
6.6
68
334
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
3.7
6.6
27
76
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.2
6.5
62
291
J02AC01
ATC
fluconazole; systemic
1.5
6.5
267
2014
J01FF01
ATC
clindamycin; systemic
1.6
6.5
170
1147
M79.1
ICD-10 Finland
Myalgia
2.0
6.4
81
429
M79.6
ICD-10 Finland
Pain in limb
1.6
6.4
232
1695
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.6
6.4
217
1559
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.3
6.4
57
260
R05
ICPC
Cough
1.7
6.4
147
956
R51.80
ICD-10 Finland
Headache
1.9
6.4
94
529
WX720
NOMESCO Finland
Own respiration
3.1
6.4
32
105
M48.0
ICD-10 Finland
Spinal stenosis
1.9
6.4
90
499
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
3.0
6.4
34
117
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
6.0
6.3
16
27
D09
ICPC
Nausea
3.0
6.3
33
112
A02BA02
ATC
ranitidine; systemic
1.7
6.3
143
927
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.5
6.3
343
2750
3312
FHL
Probing under general anesthesia
+∞
6.3
6
*
CBN20
NOMESCO Finland
Shortening of eyelid retractors
+∞
6.3
6
*
CBJ30
NOMESCO Finland
Plastic repair of levator aponeurosis of eyelid
+∞
6.3
6
*
CBF99
NOMESCO Finland
Other operation for ectropion
+∞
6.3
6
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.5
6.3
253
1898
M02AA07
ATC
piroxicam; topical
1.5
6.2
244
1820
J01DA01
ATC
[U] cefalexin; systemic
1.5
6.1
393
3254
Z01.2
ICD-10 Finland
Dental examination
1.5
6.1
249
1868
H03AA01
ATC
levothyroxine sodium; systemic
1.6
6.0
163
1103
A02BC01
ATC
omeprazole; systemic
1.6
6.0
183
1277
R03BB04
ATC
tiotropium bromide; inhalant
2.1
6.0
64
319
Mortality – FinRegistry
↥Association
Association between endpoint H7_EPIPHORA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_EPIPHORA | 0.846 [0.73, 0.98] | 0.023 |
| Birth year | 0.995 [0.99, 1.0] | 0.288 |
During the follow-up period (1.1.1998 — 31.12.2019), 339 out of 2954 females with H7_EPIPHORA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_EPIPHORA | 0.996 [0.84, 1.18] | 0.961 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 302 out of 1479 males with H7_EPIPHORA died.
Mortality risk
Mortality risk for people of age
years, who have H7_EPIPHORA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.104% | 0.193% |
| 5 | 0.536% | 1.29% |
| 10 | 1.339% | 3.071% |
| 15 | 2.565% | 5.718% |
| 20 | 4.456% | 9.408% |
Relationships between endpoints
↥Index endpoint: H7_EPIPHORA – Epiphora
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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