Unspecified abortion

O15_ABORT_UNS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O06
  • Hospital discharge: ICD-9 637
  • Cause of death: ICD-10 O06
  • Cause of death: ICD-9 637

2 out of 7 registries used, show all original rules.

2028

4. Check minimum number of events

None

2028

5. Include endpoints

None

2028

6. Filter based on genotype QC (FinnGen only)

2028

Control definitions (FinnGen only)

Control exclude
O15_PREG_ABORT

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF3
Parent code in ICD-10
O00-O08
Name in latin
Abortus non specificatus

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 14135 14135 -
Only index persons 13715 13715 -
Unadjusted period prevalence (%)
Whole population 0.40 0.40 -
Only index persons 0.50 0.50 -
Median age at first event (years)
Whole population - 30.19 -
Only index persons - 30.17 -

-FinnGen-

Key figures

All Female Male
Number of individuals 2028 2028 -
Unadjusted period prevalence (%) 0.69 0.69 -
Median age at first event (years) 30.22 30.22 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1827
Matched controls
18270
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8502
FHL
Evacuation and abrasion
597.0
323.0
1105
46
6370A
ICD-9 Finland
Unspecified abortion, Complicated by genital tract and pelvic infection
+∞
323.0
1496
*
6350C
ICD-9 Finland
Legally induced abortion, Complicated by genital tract and pelvic infection[ABORTUS PROV LEGAL SINE COMPL,SOSIAALISET SYYT]
+∞
288.4
269
*
8511
FHL
Cervical dilation and drainage with suction
336.9
209.1
208
7
O04.9
ICD-10 Finland
Medical abortion, complete or unspecified, without complication
1114.1
207.4
199
*
6340A
ICD-9 Finland
Spontaneous abortion, Complicated by genital tract and pelvic infection
+∞
199.7
188
*
O06.1
ICD-10 Finland
Unspecified abortion, incomplete, complicated by delayed or excessive haemorrhage
+∞
192.1
181
*
O02.1
ICD-10 Finland
Missed abortion
1008.2
189.1
182
*
8501
FHL
Emptying the uterus with suction
347.6
187.0
186
6
6310A
ICD-9 Finland
Other abnormal product of conception[OVUM ABORTIVUM]
+∞
161.9
153
*
64199
ICD-8 Finland
Abortion induced for other legal indications, Without mention of sepsis or toxaemia
+∞
131.9
125
*
6320A
ICD-9 Finland
Missed abortion[ABORTUS INHIBITUS (""""MISSED ABORTION"""")]
+∞
120.1
114
*
O02.0
ICD-10 Finland
Blighted ovum and nonhydatidiform mole
+∞
116.9
111
*
6331A
ICD-9 Finland
Ectopic pregnancy, Tubal pregnancy
+∞
103.1
98
*
8509
FHL
Other measure in this category
1022.3
100.1
97
*
64091
ICD-8 Finland
Medical termination of pregnancy, Weakness (medical-social reason)
+∞
99.9
95
*
O03.9
ICD-10 Finland
Spontaneous abortion, Complete or unspecified, without complication
157.4
99.2
104
7
MBA03
NOMESCO Finland
Curettage of uterus after delivery or abortion
17.1
98.5
160
102
8513
FHL
Softening of cervix with abortifacient or laminars and associated surgical emptying of the uterus
492.6
95.3
94
*
MBA00
NOMESCO Finland
Vacuum aspiration from uterus after delivery or abortion
48.0
92.7
113
25
64399
ICD-8 Finland
Spontaneous abortion, Without mention of sepsis or toxaemia
+∞
91.4
87
*
LCH00
NOMESCO Finland
Vacuum aspiration of products of conception from uterus
149.8
68.4
72
5
O06.9
ICD-10 Finland
Unspecified abortion, complete or unspecified, without complication
+∞
63.9
61
*
MBA96
NOMESCO Finland
Other removal of retained products of conception after delivery or abortion
52.0
62.6
75
15
LCH03
NOMESCO Finland
Evacuation of products of conception and curettage of uterus
119.7
54.1
58
5
O03.4
ICD-10 Finland
Spontaneous abortion, Incomplete, without complication
+∞
51.3
49
*
LCH11
NOMESCO Finland
Pharmacologic abortion
51.6
50.2
60
12
1410
FHL
Laparoscopy
4.8
48.9
173
389
O03.1
ICD-10 Finland
Spontaneous abortion, Incomplete, complicated by delayed or excessive haemorrhage
+∞
48.1
46
*
6500B
ICD-9 Finland
Delivery in a completely normal case[PARTUS SINE COMPLICATIONE]
2.0
40.7
798
5130
O00.1
ICD-10 Finland
Tubal pregnancy
+∞
38.7
37
*
N96
ICD-10 Finland
Habitual aborter
353.8
35.1
35
*
LCH13
NOMESCO Finland
Vacuum aspiration from uterus after medically induced abortion
97.0
34.8
38
*
8113
FHL
Fractional scraping
3.8
34.3
152
422
6400A
ICD-9 Finland
Haemorrhage in early pregnancy, Threatened abortion
7.9
33.9
79
104
8519
FHL
Other measure in this category
332.9
33.0
33
*
64594
ICD-8 Finland
Other abortion, Retentio ovi (partialis)
+∞
32.4
31
*
6341A
ICD-9 Finland
NA
+∞
32.4
31
*
Z64.0
ICD-10 Finland
Problems related to unwanted pregnancy
20.9
31.8
47
23
Z32.1
ICD-10 Finland
Pregnancy confirmed
3.4
31.6
162
506
MA1AE
NOMESCO Finland
Ultrasound examination of early pregnancy (before 12. postmenstrual week)
3.5
30.5
152
464
8512
FHL
Cervical dilatation and other surgical evacuation
152.4
28.7
30
*
O06.0
ICD-10 Finland
Unspecified abortion, incomplete, complicated by genital tract and pelvic infection
+∞
27.1
26
*
O06.4
ICD-10 Finland
Unspecified abortion, incomplete, without complication
+∞
26.1
25
*
P01AB01
ATC
metronidazole; oral, rectal
1.7
25.5
843
6127
MBA05
NOMESCO Finland
Curettage of uterus after abortion
+∞
25.1
24
*
O04.1
ICD-10 Finland
Medical abortion, incomplete, complicated by delayed or excessive haemorrhage
+∞
25.1
24
*
8231
FHL
Salpingectomy
91.4
24.7
27
*
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.7
23.6
704
4928
O20.0
ICD-10 Finland
Threatened abortion
4.9
23.3
77
161
8115
FHL
Laparoscenes (including Douglas)
28.6
23.2
31
11
64598
ICD-8 Finland
Other abortion
+∞
23.0
22
*
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
2.7
21.4
154
603
Z32.0
ICD-10 Finland
Pregnancy, not (yet) confirmed
8.4
20.5
45
55
8234
FHL
Sectio tubae
+∞
19.8
19
*
O00.9
ICD-10 Finland
Ectopic pregnancy, unspecified
202.1
19.6
20
*
8514
FHL
Abortion-induced abortion and associated surgical emptying of the uterus
202.1
19.6
20
*
Z30.2
ICD-10 Finland
Sterilization
1.9
19.2
333
1945
6350D
ICD-9 Finland
Legally induced abortion, Complicated by genital tract and pelvic infection[ABORT PROV LEGAL SINE COMPL,ÄIDIN IKÄ <17 V TAI >40]
+∞
18.8
18
*
64190
ICD-8 Finland
Artificial termination of pregnancy performed on the basis of another legal reason, Humanitarian reason
+∞
18.8
18
*
64099
ICD-8 Finland
Abortion induced for medical indications, Without mention of sepsis or toxaemia
+∞
18.8
18
*
MBA40
NOMESCO Finland
Pharmacological evacuation of uterus after abortion
+∞
17.7
17
*
O03.6
ICD-10 Finland
Spontaneous abortion, Complete or unspecified, complicated by delayed or excessive haemorrhage
+∞
17.7
17
*
O06.6
ICD-10 Finland
Unspecified abortion, complete or unspecified, complicated by delayed or excessive haemorrhage
+∞
17.7
17
*
ZXD05
NOMESCO Finland
Urgent procedure
1.7
17.1
469
3141
6150A
ICD-9 Finland
Inflammatory diseases of uterus, except cervix, Acute[ENDOMETRITIS, ENDOMYOMETRITIS ET PERIMETRITIS ACUTA]
13.4
17.0
29
22
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
2.4
16.7
154
688
ZXE00
NOMESCO Finland
One hour or less
1.5
16.1
670
4978
G02CB01
ATC
bromocriptine; systemic
3.5
15.0
69
200
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.6
14.8
431
2923
6339X
ICD-9 Finland
Ectopic pregnancy, Unspecified ectopic pregnancy
+∞
14.6
14
*
O04.6
ICD-10 Finland
Medical abortion, complete or unspecified, complicated by delayed or excessive haemorrhage
+∞
14.6
14
*
6391A
ICD-9 Finland
Complications following abortion and ectopic and molar pregnancies, Delayed or excessive haemorrhage
+∞
14.6
14
*
6349X
ICD-9 Finland
Spontaneous abortion, Without mention of complication
+∞
14.6
14
*
63150
ICD-8 Finland
Ectopic pregnancy, Tubaria rupta, sepsi non indicata
+∞
14.6
14
*
W79
ICPC
Unwanted pregnancy
42.8
14.1
17
*
R07.4
ICD-10 Finland
Chest pain, unspecified
1.7
14.1
367
2409
XLA10
NOMESCO Finland
NA
2.2
14.0
142
667
6440A
ICD-9 Finland
Early or threatened labour, Threatened premature labour[PARTUS PRAEMATURUS IMMINENS]
2.9
13.9
83
291
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
13.6
617
4632
O06.3
ICD-10 Finland
Unspecified abortion, incomplete, with other and unspecified complications
+∞
13.6
13
*
8831
FHL
Uterine exploration and / or scraping or suction emptying (ad 24 hours)
5.9
13.2
36
62
8811
FHL
Cesarean section
1.9
13.0
217
1240
8232
FHL
Resection room
70.4
12.6
14
*
6350A
ICD-9 Finland
Legally induced abortion, Complicated by genital tract and pelvic infection[ABORTUS PROV LEGAL SINE COMPL,LÄÄKETIET SYYT (ÄID)]
+∞
12.5
12
*
O03.0
ICD-10 Finland
Spontaneous abortion, Incomplete, complicated by genital tract and pelvic infection
+∞
12.5
12
*
6350B
ICD-9 Finland
Legally induced abortion, Complicated by genital tract and pelvic infection[ABORTUS PROV LEGAL SINE COMPL,LÄÄKETIET SYYT (SIK)]
+∞
12.5
12
*
V220A
ICD-9 Finland
Normal pregnancy, Supervision of normal first pregnancy
2.8
12.3
81
302
O80.0
ICD-10 Finland
Spontaneous vertex delivery
1.5
12.2
564
4231
8841
FHL
Uterine emptying and scraping (ad 6 weeks)
6.3
11.7
30
48
J01DA01
ATC
[U] cefalexin; systemic
1.4
11.6
1147
9917
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
1.7
11.5
244
1506
Z35.4
ICD-10 Finland
Supervision of pregnancy with grand multiparity
7.0
11.3
27
39
6289B
ICD-9 Finland
Infertility, female, Of unspecified origin[STERILITAS ET INFERTILITAS MULIERIS NUD SEC]
6.3
11.2
29
47
J01DB01
ATC
cefalexin; oral
1.5
11.2
1431
12946
Z35.2
ICD-10 Finland
Supervision of pregnancy with other poor reproductive or obstetric history
3.9
10.9
44
116
6202X
ICD-9 Finland
Noninflammatory disorders of ovary, Fallopian tube and broad ligament, Other and unspecified ovarian cyst
3.9
10.9
44
116
AA1AD
NOMESCO Finland
CT of head and brain
1.6
10.5
270
1753
64591
ICD-8 Finland
Other abortion, Endometritis post abortum
+∞
10.4
10
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
10.4
426
3092
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.4
10.2
509
3851
N81.6
ICD-10 Finland
Rectocele
1.9
9.8
142
773
N71.0
ICD-10 Finland
Acute inflammatory disease of uterus
2.8
9.8
61
220
G01AF05
ATC
econazole; vaginal
1.6
9.6
248
1613
1413
FHL
Laparoscopy and other therapeutic procedure
2.4
9.6
81
349
O20.9
ICD-10 Finland
Haemorrhage in early pregnancy, unspecified
3.5
9.5
43
126
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
1.6
9.4
250
1638
64595
ICD-8 Finland
Other abortion, Haemorrhagia post abortum NUD
+∞
9.4
9
*
G03DA04
ATC
progesterone; systemic, rectal, vaginal
2.0
9.3
116
597
63230
ICD-8 Finland
Haemorrhage of pregnancy, Threatened abortion
3.1
9.3
49
161
6671A
ICD-9 Finland
Retained placenta or membranes, without haemorrhage, Retained portions of placenta or membranes, without haemorrhage
5.3
9.2
27
52
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
1.8
9.1
149
847
LGA21
NOMESCO Finland
Laparoscopic sterilisation by constriction of Fallopian tubes
1.7
8.7
183
1122
G03GB02
ATC
clomifene; oral
2.2
8.7
88
414
V230A
ICD-9 Finland
Supervision of high-risk pregnancy, Pregnancy with history of infertility
3.3
8.7
42
130
ZXD20
NOMESCO Finland
Day surgery
1.6
8.7
238
1569
N92.6
ICD-10 Finland
Irregular menstruation, unspecified
1.8
8.7
157
920
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.3
8.6
990
8562
M54.5
ICD-10 Finland
Low back pain
1.4
8.5
556
4386
MBA30
NOMESCO Finland
Manual removal of placenta from delivered uterus
3.2
8.5
42
132
O04
ICD-10 Finland
Medical abortion
90.5
8.4
9
*
6463A
ICD-9 Finland
Other complications of pregnancy, not elsewhere classified, Habitual aborter
90.5
8.4
9
*
6338X
ICD-9 Finland
Ectopic pregnancy, Other ectopic pregnancy
+∞
8.3
8
*
O03.3
ICD-10 Finland
Spontaneous abortion, Incomplete, with other and unspecified complications
+∞
8.3
8
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.4
8.3
618
4986
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.3
8.2
793
6660
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.3
8.2
865
7361
W83
ICPC
Abortion induced
33.5
8.1
10
*
MA2JE
NOMESCO Finland
Ultrasound screening of fetal nuchal translucency
2.1
8.1
87
424
J01CA08
ATC
pivmecillinam; oral
1.3
8.1
858
7305
SPAT1263
SPAT
Sampling
1.4
8.0
613
4954
6430A
ICD-9 Finland
Excessive vomiting in pregnancy, Mild hyperemesis gravidarum
6.3
8.0
20
32
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.3
7.9
626
5090
M03BX02
ATC
tizanidine; oral
1.3
7.7
1188
10645
WX290
NOMESCO Finland
Other blockade of nerve
1.3
7.7
774
6518
W78
ICPC
Pregnancy
1.8
7.6
116
646
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.4
7.6
404
3071
8119
FHL
Other measure in this category
10.1
7.5
14
14
M79.6
ICD-10 Finland
Pain in limb
1.3
7.4
578
4676
SPAT1301
SPAT
No procedures
1.4
7.4
406
3101
O06.5
ICD-10 Finland
Unspecified abortion, complete or unspecified, complicated by genital tract and pelvic infection
+∞
7.3
7
*
XF600
NOMESCO Finland
Bloodpressure measurement
2.2
7.2
73
344
R51.80
ICD-10 Finland
Headache
1.5
7.2
248
1722
V252A
ICD-9 Finland
Contraceptive management, Sterilisation
1.6
7.1
189
1237
G44.2
ICD-10 Finland
Tension-type headache
1.5
7.0
239
1657
SPAT1283
SPAT
Restricted health certificate
1.4
7.0
331
2454
8321
FHL
Insertion or removal of an IUD under anesthesia
3.2
6.9
34
108
G02AB01
ATC
methylergometrine; systemic
5.2
6.9
20
39
WX110
NOMESCO Finland
Local anesthesy
1.3
6.9
1182
10654
Z35.1
ICD-10 Finland
Supervision of pregnancy with history of abortive outcome
11.0
6.8
12
11
8203
FHL
Salpingectomy
9.3
6.8
13
14
6201A
ICD-9 Finland
Noninflammatory disorders of ovary, Fallopian tube and broad ligament, Corpus luteum cyst or haematoma
5.7
6.8
18
32
O03
ICD-10 Finland
Spontaneous abortion
16.7
6.7
10
6
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.4
6.7
469
3719
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
1.7
6.7
144
890
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.6
6.7
149
934
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
1.5
6.6
200
1349
B02AA02
ATC
tranexamic acid; systemic
1.4
6.6
391
3022
D10
ICPC
Vomiting
1.9
6.4
85
451
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
6.3
1255
11464
G01AF01
ATC
metronidazole; vaginal
1.4
6.3
259
1870
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
1.6
6.3
165
1076
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.3
6.3
1032
9192
R21
ICPC
Throat symptom/complaint
1.4
6.3
304
2263
6342A
ICD-9 Finland
Spontaneous abortion, Complicated by damage to pelvic organs or tissues
+∞
6.3
6
*
8239
FHL
Other measure in this category
+∞
6.3
6
*
O04.3
ICD-10 Finland
Medical abortion, incomplete, with other and unspecified complications
+∞
6.3
6
*
O02.9
ICD-10 Finland
Abnormal product of conception, unspecified
+∞
6.3
6
*
63151
ICD-8 Finland
Ectopic pregnancy, Tubaria NUD sepsi non indicata
+∞
6.3
6
*
O04.0
ICD-10 Finland
Medical abortion, incomplete, complicated by genital tract and pelvic infection
+∞
6.3
6
*
Z39.2
ICD-10 Finland
Routine postpartum follow-up
1.7
6.2
125
758
W82
ICPC
Abortion spontaneous
26.8
6.2
8
*
LEF03
NOMESCO Finland
Posterior colporrpahy with sutures for primary rectocele
2.0
6.2
75
384
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.6
6.2
147
934
TPH04
NOMESCO Finland
Cathetrisation of vein
1.4
6.1
260
1887
Z37.0
ICD-10 Finland
Single live birth
1.6
6.0
141
893
J01AA02
ATC
doxycycline; systemic
1.3
6.0
1409
13114
MAX99
NOMESCO Finland
Assistance to normal delivery
1.8
6.0
97
552

Mortality – FinRegistry

Association

Association between endpoint O15_ABORT_UNS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_ABORT_UNS.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: O15_ABORT_UNS – Unspecified abortion

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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