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Clear cell adenocarcinoma of kidney

C3_KIDNEY_CLEAR_CELL_CARCINOMA

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 C64
  • Cancer registry: Morphology ICD-O-3 8310
  • Cancer registry: Behaviour codes 3

1 out of 7 registries used, show all original rules.

1549

4. Check minimum number of events

None

1549

5. Include endpoints

None

1549

6. Filter based on genotype QC (FinnGen only)

1549

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF9

Similar endpoints

List of similar endpoints to Clear cell adenocarcinoma of kidney based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 1549 589 960
Unadjusted period prevalence (%) 0.34 0.20 0.42
Median age at first event (years) 67.78 68.40 67.40

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1406
Matched controls
14059
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
3545.4
323.0
1347
87
8310/3-C64.9
ICD-O-3
Clear cell adenocarcinoma, NOS, of kidney, NOS
+∞
323.0
1406
*
D41.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Kidney
317.7
323.0
1067
137
KAC11
NOMESCO Finland
Total nephrectomy with capsule, transcutaneous
538.5
323.0
413
11
KAC10
NOMESCO Finland
Total nephrectomy with capsule
142.3
315.4
328
30
B01AB10
ATC
tinzaparin; parenteral
13.6
243.2
459
485
JN4AD
NOMESCO Finland
Body CT examination
10.9
233.7
502
682
C64
ICD-10 Finland
Malignant neoplasm of kidney, except renal pelvis
118.1
213.6
228
23
KAD01
NOMESCO Finland
Percutaneous endoscopic partial nephrectomy
153.1
211.3
220
17
KAD00
NOMESCO Finland
Partial nephrectomy
116.1
194.3
208
21
197
Kela drug reimbursment
Sunitinib
178.3
180.5
186
12
WX302
NOMESCO Finland
Thoracal epidural anesthesy
12.5
178.3
343
354
TPH07
NOMESCO Finland
Cathetrisation of artery
7.3
169.8
474
919
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
10.9
166.8
344
404
JN4CD
NOMESCO Finland
Very extensive body CT
13.5
166.3
306
284
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.4
158.7
491
1081
JN4BD
NOMESCO Finland
Extensive body CT
6.5
151.6
462
988
L01XE04
ATC
[U] sunitinib; oral
154.0
132.9
139
10
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
29.0
128.3
176
69
1502
Kela drug reimbursment
Cabozantinib
339.2
123.4
123
*
130
Kela drug reimbursment
Malignant tumour
6.4
123.1
367
737
3012
Kela drug reimbursment
Cabozantinib
323.6
118.1
118
*
WD505
NOMESCO Finland
Simple enzyme inhibitor or similar therapy of methastized malignancy
35.5
113.0
147
46
B01AB05
ATC
enoxaparin; parenteral
3.7
111.1
718
3096
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
19.5
108.3
168
97
WX408
NOMESCO Finland
General anesthesy, balanced
3.7
107.3
657
2688
159
Kela drug reimbursment
Pazopanib
210.4
95.7
98
5
WX402
NOMESCO Finland
General anaesthesia
4.0
88.2
423
1357
L01XE26
ATC
[U] cabozantinib; oral
800.9
78.1
76
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
8.5
77.3
178
235
U75
ICPC
Malignant neoplasm of kidney
267.5
75.2
76
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.8
74.8
870
5120
L01EX07
ATC
cabozantinib; oral
370.3
71.3
71
*
ZXE20
NOMESCO Finland
More than three and less than five hours
3.6
69.3
373
1282
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
7.8
67.9
165
236
322
Kela drug reimbursment
Sunitinib
183.9
67.7
70
*
N02BE01
ATC
paracetamol; systemic, rectal
4.6
63.8
1315
10659
L01XE11
ATC
[U] pazopanib; oral
140.5
63.4
67
5
WF049
NOMESCO Finland
Radiotherapy of metastasis
7.3
58.1
147
222
N02AX02
ATC
tramadol; systemic, rectal
2.5
56.7
767
4597
WZC30
NOMESCO Finland
Teaching
3.3
56.5
334
1208
KAC00
NOMESCO Finland
Nephrectomy
49.8
51.5
62
13
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.4
50.7
592
3222
JN3AD
NOMESCO Finland
Abdominal CT examination
3.8
45.5
209
611
158
Kela drug reimbursment
Everolimus
92.9
41.0
45
5
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
40.9
409
2001
168
Kela drug reimbursment
Axitinib
408.7
40.3
40
*
KAC01
NOMESCO Finland
Percutaneous endoscopic nephrectomy
408.7
40.3
40
*
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
15.7
40.0
66
44
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
5.0
37.7
127
273
ZXE10
NOMESCO Finland
More than one and less than three hours
2.1
37.2
609
3725
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.4
36.6
367
1781
R4110
NOMESCO Finland
Physiotherapy
2.2
36.5
482
2675
C64.80
ICD-10 Finland
Wilms tumour
130.1
35.9
38
*
N02AA05
ATC
oxycodone; systemic
2.6
35.8
299
1310
XX3DW
NOMESCO Finland
Time consuming IT work
2.9
35.5
239
919
KA3LT
NOMESCO Finland
Njurlesion coagulation
68.5
35.1
40
6
WX704
NOMESCO Finland
Intubation
3.6
34.2
165
497
KA1AE
NOMESCO Finland
Kidney ultrasound examination
5.6
33.6
101
190
R31
ICD-10 Finland
Unspecified haematuria
2.8
33.5
237
936
S18
ICPC
Laceration/cut
2.0
31.9
702
4738
343
Kela drug reimbursment
Pazopanib
116.0
31.8
34
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.6
31.5
153
463
C08CA01
ATC
amlodipine; oral
2.0
30.9
632
4132
WX110
NOMESCO Finland
Local anesthesy
2.0
30.2
969
7454
A03FA01
ATC
metoclopramide; systemic, rectal
2.3
29.9
344
1763
Z51.5
ICD-10 Finland
Palliative care
3.4
29.8
154
489
L01EX01
ATC
sunitinib; oral
158.3
29.8
31
*
L01XE10
ATC
[U] everolimus; oral
81.9
28.8
32
*
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
5.9
28.7
83
149
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.0
28.7
185
686
U14
ICPC
Kidney symptom/complaint
8.7
28.4
62
74
L01XE17
ATC
[U] axitinib; oral
286.9
27.8
28
*
WD515
NOMESCO Finland
Demanding therapy of malignancy with enzyme inhibitors and similar treatments
26.0
27.6
38
15
I10
ICD-10 Finland
Essential (primary) hypertension
1.9
27.0
951
7391
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
3.7
27.0
124
358
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
26.2
298
1504
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
6.4
26.2
70
114
D41.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Renal pelvis
31.6
26.0
34
11
KH1CD
NOMESCO Finland
Very extensive urinary tract ultrasound examination
9.0
25.9
55
63
UKC02
NOMESCO Finland
Cystoscopy
2.1
25.6
327
1737
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.1
24.2
138
470
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
3.2
23.4
131
438
C79.30
ICD-10 Finland
Secondary malignant tumor of the cerebrum
10.3
22.9
45
45
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.5
22.9
203
904
WX725
NOMESCO Finland
Noninvasive ventilation
3.6
22.3
104
304
N18.8
ICD-10 Finland
Other chronic renal failure
4.3
21.5
81
196
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.2
21.2
116
383
GDB11
NOMESCO Finland
Thoracoscopic wedge resection of lung
12.8
19.9
35
28
361
Kela drug reimbursment
Axitinib
202.7
19.6
20
*
ZXA05
NOMESCO Finland
Left side
1.8
19.5
408
2579
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.0
19.0
115
407
PHN71
NOMESCO Finland
Excision of tumor mass from inferior vena cava
+∞
18.8
18
*
PHE70
NOMESCO Finland
Thrombectomy of inferior vena cava
+∞
18.8
18
*
340
Kela drug reimbursment
Everolimus
101.4
18.6
20
*
JN3KE
NOMESCO Finland
Abdominal ultrasound with added contrast
12.0
18.3
33
28
BCA30
NOMESCO Finland
Unilateral adrenalectomy
25.4
18.2
25
10
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.8
18.1
123
469
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.8
18.1
118
439
JN1CD
NOMESCO Finland
Very extensive CT examination of upper part of abdomen
9.2
17.9
37
41
SPAT1153
SPAT
Removal of sutures
1.7
17.8
503
3472
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.8
17.8
119
447
PJD43
NOMESCO Finland
Excision of aortic lymph nodes
67.5
17.7
20
*
GD1AD
NOMESCO Finland
Thorax CT examination
3.1
17.7
102
349
D30.0
ICD-10 Finland
Benign neoplasm: Kidney
9.4
17.2
35
38
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
5.5
17.2
51
96
KA4AT
NOMESCO Finland
Cytology of kidney with ultrasound guidance
40.6
16.3
20
5
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
6.3
15.5
41
67
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.1
15.4
182
922
R93.4
ICD-10 Finland
Abnormal findings on diagnostic imaging of urinary organs
9.3
15.2
31
34
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
3.0
14.9
87
302
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
4.5
14.7
52
119
L01EX03
ATC
pazopanib; oral
+∞
14.6
14
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.6
14.3
535
3919
TK800
NOMESCO Finland
Hemodialysis
3.9
14.1
57
149
C03CA01
ATC
furosemide; systemic
1.6
14.0
431
2996
ZXA00
NOMESCO Finland
Right side
1.6
13.7
407
2800
PC5DT
NOMESCO Finland
Embolisation of tumor of kidney
+∞
13.6
13
*
L01EK01
ATC
axitinib; oral
+∞
13.6
13
*
JN1BD
NOMESCO Finland
Extensive CT examination of upper part of abdomen
7.3
13.3
31
43
ZXC96
NOMESCO Finland
Robot assisted procedure
3.2
13.2
68
217
WX290
NOMESCO Finland
Other blockade of nerve
1.6
12.6
497
3658
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
7.4
12.5
29
40
Z85.5
ICD-10 Finland
Personal history of malignant neoplasm of urinary tract
131.1
12.5
13
*
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.5
12.3
98
410
A02BC02
ATC
pantoprazole; systemic
1.5
12.3
885
7438
N28.1
ICD-10 Finland
Cyst of kidney
4.9
12.2
39
81
M05BX04
ATC
denosumab; parenteral
2.7
12.2
85
331
C65
ICD-10 Finland
Malignant neoplasm of renal pelvis
16.0
12.1
19
12
ZX120
NOMESCO Finland
Intravenous
2.1
12.0
145
739
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.7
11.6
255
1600
A11CC03
ATC
alfacalcidol; systemic
3.8
11.6
49
134
V03AE01
ATC
polystyrene sulfonate; oral
5.1
11.4
35
70
H02AB02
ATC
dexamethasone; systemic
2.0
11.2
149
788
C79.7
ICD-10 Finland
Secondary malignant neoplasm of adrenal gland
20.2
11.1
16
8
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
3.7
11.1
47
129
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
2.4
11.1
93
401
KH1AD
NOMESCO Finland
CT of urinary organs
2.9
11.0
68
246
198
Kela drug reimbursment
Sorafenib
12.0
10.8
19
16
L01XE05
ATC
[U] sorafenib; oral
21.6
10.7
15
7
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
1.9
10.7
164
917
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
2.7
10.6
70
264
JN3DG
NOMESCO Finland
Very extensive MRI examination with high intensity magnet
14.3
10.5
17
12
ZXD05
NOMESCO Finland
Urgent procedure
1.5
10.4
399
2891
A10BH05
ATC
linagliptin; oral
2.4
10.2
90
397
WX306
NOMESCO Finland
Lumbar epidural anesthesy
2.8
10.2
64
235
AA1BD
NOMESCO Finland
Extensive CT of head and brain
3.2
10.1
52
167
BCA31
NOMESCO Finland
Endoscopic unilateral adrenalectomy
9.2
10.0
20
22
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.7
9.8
237
1526
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
3.2
9.8
50
160
N02AJ06
ATC
codeine and paracetamol; systemic
1.5
9.7
479
3656
205
Kela drug reimbursment
Chronic hypertension
1.5
9.6
431
3221
D44.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Adrenal gland
4.3
9.6
34
80
R50.9
ICD-10 Finland
Fever, unspecified
1.8
9.5
187
1132
M84.4
ICD-10 Finland
Pathological fracture, not elsewhere classified
15.1
9.5
15
10
KB1CG
NOMESCO Finland
Extensive MRI examination of urinary tract with high intensity magnet
100.7
9.4
10
*
Z90.5
ICD-10 Finland
Acquired absence of kidney
30.2
9.4
12
*
Z3226
NOMESCO Finland
Physiotherapist
1.6
9.4
253
1676
D41
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour of urinary organs
+∞
9.4
9
*
M04AA01
ATC
allopurinol; systemic
1.7
9.4
205
1284
J01DB01
ATC
cefalexin; oral
1.5
9.3
1090
9807
M49.5*C79.5
ICD-10 Finland
Metastatic fracture of vertebra
36.9
9.0
11
*
J01MA02
ATC
ciprofloxacin; systemic
1.4
9.0
532
4189
WW500
NOMESCO Finland
Blood transfusion
2.5
8.9
68
280
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.9
8.9
131
719
AA1AD
NOMESCO Finland
CT of head and brain
1.5
8.9
352
2556
RJ128
NOMESCO Finland
NA
12.6
8.9
15
12
WX892
NOMESCO Finland
Monitored bed care
1.9
8.8
121
652
WF004
NOMESCO Finland
Palliative radiotherapy
3.3
8.6
42
131
JAD30
NOMESCO Finland
Repair of incisional hernia using prosthetic material
3.8
8.6
34
90
C77.2
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Intra-abdominal lymph nodes
10.1
8.5
16
16
E89.6
ICD-10 Finland
Postprocedural adrenocortical(-medullary) hypofunction
90.6
8.4
9
*
R4190
NOMESCO Finland
Nutritional therapy
2.9
8.3
48
168
C78.8
ICD-10 Finland
Secondary malignant neoplasm of other and unspecified digestive organs
9.5
8.3
16
17
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
4.0
8.2
31
79
ZXE00
NOMESCO Finland
One hour or less
1.4
8.2
498
3929
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
3.2
8.1
41
132
U06
ICPC
Haematuria
2.9
8.1
47
165
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
3.0
8.1
44
149
N17.9
ICD-10 Finland
Acute renal failure, unspecified
2.4
8.1
66
284
NK6AN
NOMESCO Finland
Total body bone isotope imaging
2.7
8.0
52
196
105
Kela drug reimbursment
Adrenal cortical hypofunction
22.1
8.0
11
5
WX600
NOMESCO Finland
Single shot through catheter
5.7
7.8
21
37
B01AB04
ATC
dalteparin; parenteral
2.2
7.8
79
375
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
3.9
7.8
30
78
D64.9
ICD-10 Finland
Anaemia, unspecified
1.8
7.8
145
866
WX002
NOMESCO Finland
Sedation and analgesia
1.5
7.7
269
1891
A04AA02
ATC
granisetron; systemic, transdermal
2.1
7.7
83
406
H02AB09
ATC
hydrocortisone; systemic
3.2
7.6
38
122
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
2.7
7.5
48
179
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.7
7.5
141
843
1XC17
NOMESCO Finland
NA
+∞
7.3
7
*
A79
ICPC
Malignancy NOS
4.0
7.2
27
69
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.7
7.1
160
1006
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
1.5
7.0
227
1567
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
7.0
398
3079
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
2.2
7.0
69
324
YX8BD
NOMESCO Finland
Stereotactic extensive CT examination for dose design of radiotherapy
7.6
6.9
15
20
N18.0
ICD-10 Finland
End-stage renal disease
4.1
6.9
25
62
JAD11
NOMESCO Finland
Laparoscopic repair of incisional hernia
4.4
6.8
23
53
N03AX16
ATC
pregabalin; oral
1.5
6.8
292
2142
Z49.0
ICD-10 Finland
Preparatory care for dialysis
4.3
6.7
23
54
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.7
6.7
151
951
N99.0
ICD-10 Finland
Postprocedural renal failure
22.6
6.7
9
*
A06AH03
ATC
naloxegol; oral
4.5
6.7
22
50
E0000UV
ATC
NA
1.4
6.6
463
3709
SPAT1254
SPAT
Administration of medicine
1.6
6.6
188
1257
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
4.1
6.6
24
60
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.2
6.6
61
279
G04CA02
ATC
tamsulosin; oral
1.4
6.6
380
2946
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.0
6.5
85
448
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
1.9
6.5
97
540
E87.5
ICD-10 Finland
Hyperkalaemia
3.2
6.4
31
98
M907, C6488
ICD-10 Finland
NA
70.1
6.4
7
*
L01EG02
ATC
everolimus; oral (mammalian target of rapamycin kinase inhibitors (mtor))
70.1
6.4
7
*
PHN70
NOMESCO Finland
Plastic repair of inferior vena cava
70.1
6.4
7
*
C02AC05
ATC
moxonidine; oral
2.0
6.4
72
361
J01MA12
ATC
levofloxacin; systemic
1.5
6.4
253
1828
C77.1
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Intrathoracic lymph nodes
8.2
6.3
13
16
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
2.2
6.3
62
293
C79.0
ICD-10 Finland
Secondary malignant neoplasm of kidney and renal pelvis
18.1
6.3
9
5
K46.9
ICD-10 Finland
Unspecified abdominal hernia without obstruction or gangrene
7.1
6.2
14
20
N18.5
ICD-10 Finland
Chronic kidney disease, stage 5
8.6
6.1
12
14
YL1AD
NOMESCO Finland
CT examination of pelvis for dose design of radiotherapy
3.1
6.0
31
103

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_KIDNEY_CLEAR_CELL_CARCINOMA – Clear cell adenocarcinoma of kidney

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).