lactose intolerance: Inability to fully digest and absorb lactose due to limited or no lactase activity in the small intestine. Congenital intolerance is inherited following an autosomal recessive pattern but is rare. It is more often due to a gradual decline of lactase production in adulthood following the ingestion of fewer lactose-containing foods or secondary to an intestinal mucosal brush-border injury. Prevalence is highest among Asians, Native Americans and Africans. Clinical signs include abdominal cramping, bloating, flatulence and diarrhea following the dietary intake of lactose.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1131 |
4. Check minimum number of eventsNone |
1131 |
5. Include endpointsNone |
1131 |
6. Filter based on genotype QC (FinnGen only) |
1059 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Lactose intolerance, other/unspecified
based on the number of shared cases.
Similar with more cases:
- Lactose intolerance
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10993 | 6393 | 4499 |
| Only index persons | 8968 | 5282 | 3686 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.18 | 0.13 |
| Only index persons | 0.17 | 0.19 | 0.14 |
| Median age at first event (years) | |||
| Whole population | 34.08 | 43.09 | 20.61 |
| Only index persons | 30.81 | 38.17 | 20.25 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1059 | 726 | 333 |
| Unadjusted period prevalence (%) | 0.22 | 0.26 | 0.15 |
| Median age at first event (years) | 41.96 | 41.26 | 43.49 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1131
- Matched controls
- 11310
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E73.8
ICD-10 Finland
Other lactose intolerance
3731.8
320.4
294
*
E73.9
ICD-10 Finland
Lactose intolerance, unspecified
3976.6
307.7
573
*
2713A
ICD-9 Finland
Disorders of carbohydrate transport and metabolism, Intestinal disaccharidase deficiencies and disaccharide malabsorption[MALABSORPTIO LACTOSI]
+∞
307.7
296
*
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
7.3
115.7
186
295
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.5
89.2
452
1789
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.3
86.5
593
2812
A06AC01
ATC
ispaghula (psylla seeds); oral
3.4
81.0
424
1695
UJF32
NOMESCO Finland
Coloscopy
3.4
78.4
401
1576
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
4.0
64.3
210
607
K90.0
ICD-10 Finland
Coeliac disease
6.8
53.5
87
137
A02BC05
ATC
esomeprazole; systemic
2.5
49.3
527
2918
A03CA02
ATC
clidinium and psycholeptics; oral
4.7
44.2
109
252
A02BC01
ATC
omeprazole; systemic
2.5
43.8
371
1823
C10AC01
ATC
colestyramine; oral
6.9
43.7
69
105
K59.1
ICD-10 Finland
Functional diarrhoea
4.4
43.5
115
281
K30
ICD-10 Finland
Functional dyspepsia
3.2
42.0
187
652
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.5
39.1
341
1684
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
5.7
38.8
75
140
UJD02
NOMESCO Finland
Gastroscopy
4.8
38.2
90
200
A02BA02
ATC
ranitidine; systemic
2.6
37.0
262
1169
A02BC03
ATC
lansoprazole; oral
2.3
36.4
363
1894
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
3.3
36.1
147
484
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
5.0
35.3
79
168
N03AX16
ATC
[U] pregabalin
2.4
33.3
289
1411
E73
ICD-10 Finland
Lactose intolerance
42.5
33.3
41
10
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.4
32.2
264
1255
J01MA02
ATC
ciprofloxacin; systemic
2.1
32.2
448
2652
A02BC02
ATC
pantoprazole; systemic
2.2
32.0
759
5482
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.2
31.5
393
2225
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
3.0
31.5
155
569
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
4.6
31.3
77
177
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
31.2
291
1461
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.4
30.3
249
1182
R07.4
ICD-10 Finland
Chest pain, unspecified
2.2
30.2
321
1701
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
10.0
29.5
34
35
A03FA02
ATC
cisapride; oral, rectal
3.3
28.4
117
386
P01AB01
ATC
metronidazole; oral, rectal
2.0
28.2
487
3085
N02AX02
ATC
tramadol; systemic, rectal
2.0
26.6
475
3027
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
3.7
26.6
89
257
M79.6
ICD-10 Finland
Pain in limb
2.0
26.0
499
3251
R06.0
ICD-10 Finland
Dyspnoea
2.1
25.9
314
1736
J02AC01
ATC
fluconazole; systemic
2.0
25.9
490
3178
R51.80
ICD-10 Finland
Headache
2.3
25.4
230
1131
A07EC02
ATC
mesalazine; oral, rectal
3.5
24.6
90
275
G47.3
ICD-10 Finland
Sleep apnoea
2.2
24.6
245
1252
N06AX21
ATC
duloxetine; oral
2.5
24.5
166
716
R01AD09
ATC
mometasone; nasal
1.9
23.9
552
3792
M79.0
ICD-10 Finland
Rheumatism, unspecified
4.3
23.8
62
149
R01AD08
ATC
fluticasone; nasal
2.0
23.8
349
2060
K29.3
ICD-10 Finland
Chronic superficial gastritis
4.7
23.3
55
122
R42
ICD-10 Finland
Dizziness and giddiness
2.1
23.1
259
1383
H02AB04
ATC
methylprednisolone; systemic
2.4
22.9
181
836
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
21.9
464
3078
R06AE07
ATC
cetirizine; oral
1.8
21.6
530
3672
D06
ICPC
Abdominal pain localized other
2.7
21.6
123
485
A02BC04
ATC
rabeprazole; oral
2.7
21.4
123
487
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.4
21.1
165
758
R03AC02
ATC
salbutamol; inhalant
1.8
21.0
649
4808
Z71.8
ICD-10 Finland
Other specified counselling
1.9
20.9
370
2309
M54.5
ICD-10 Finland
Low back pain
1.9
20.8
416
2699
R53
ICD-10 Finland
Malaise and fatigue
2.0
20.7
290
1672
L17
ICPC
Foot/toe symptom/complaint
1.9
20.6
333
2017
A07DA03
ATC
loperamide; oral
4.2
20.3
54
132
M79.7
ICD-10 Finland
Fibromyalgia
3.8
20.1
62
169
R52.9
ICD-10 Finland
Pain, unspecified
2.6
20.1
127
528
E87.6
ICD-10 Finland
Hypokalaemia
7.4
20.0
29
40
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.2
19.9
190
947
D01
ICPC
Abdominal pain/cramps general
2.3
19.9
168
796
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
19.5
469
3203
L03
ICPC
Low back symptom/complaint
1.9
19.3
331
2037
L28
ICPC
Limited function/disability (L)
2.2
19.0
190
964
J45.9
ICD-10 Finland
Asthma, unspecified
2.0
18.9
230
1258
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
8.2
18.8
25
31
E73.0
ICD-10 Finland
Congenital lactase deficiency
+∞
18.8
18
*
Z3226
NOMESCO Finland
Physiotherapist
2.1
18.7
219
1180
N03AX12
ATC
[U] gabapentin; oral
2.2
18.6
187
950
L01
ICPC
Neck symptom/complaint
2.1
18.4
195
1011
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.6
18.4
112
456
N06AB04
ATC
citalopram; systemic
2.0
18.4
243
1367
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.2
18.1
173
861
M03BX02
ATC
tizanidine; oral
1.7
18.0
677
5208
UJF30
NOMESCO Finland
Ileoscopy through colon
2.5
18.0
121
517
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.8
18.0
94
354
A06AC51
ATC
ispaghula, combinations; oral
3.3
17.7
70
225
M01AE03
ATC
ketoprofen; systemic, rectal
1.8
17.6
389
2573
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
2.9
17.4
86
314
C10AX09
ATC
ezetimibe; oral
2.4
17.4
127
564
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.2
17.4
167
833
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.8
17.3
318
1988
N06AA09
ATC
amitriptyline; systemic
2.5
17.3
116
495
K59.09
ICD-10 Finland
Constipation, unspecified
2.9
17.3
82
293
N05BA04
ATC
oxazepam; oral
1.9
17.3
302
1859
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
15.1
17.2
28
19
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.7
16.9
99
395
D11
ICPC
Diarrhoea
2.2
16.8
164
822
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.2
16.8
165
829
C05AA08
ATC
fluocortolone; rectal, topical
2.2
16.8
156
767
H02AB06
ATC
prednisolone; systemic
1.7
16.7
500
3588
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.0
16.6
202
1100
J01FA10
ATC
azithromycin; systemic
1.7
16.6
678
5284
J01AA02
ATC
doxycycline; systemic
1.8
16.6
825
6791
J01DA01
ATC
[U] cefalexin
1.7
16.5
679
5296
SPAT1336
SPAT
Request for examination
3.5
16.5
57
168
M54.4
ICD-10 Finland
Lumbago with sciatica
2.0
16.4
204
1120
M01AB05
ATC
diclofenac; systemic, rectal
1.7
16.3
702
5534
N06AX11
ATC
mirtazapine; oral
1.7
16.3
377
2514
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
2.7
16.2
92
362
M79.1
ICD-10 Finland
Myalgia
2.1
16.1
184
979
N05AH04
ATC
quetiapine; oral
1.9
15.9
223
1274
A07EC01
ATC
sulfasalazine; oral, rectal
2.5
15.9
106
451
L48
ICPC
Musculoskeletal, Clarification/discussion RFE/demand
7.3
15.7
23
32
Z01.2
ICD-10 Finland
Dental examination
1.7
15.6
524
3853
M25.5
ICD-10 Finland
Pain in joint
1.7
15.6
362
2411
A07EA06
ATC
budesonide; oral, local oral
3.4
15.3
57
176
A99
ICPC
Disease/condition unspecnature/site
2.4
15.3
114
510
G44.2
ICD-10 Finland
Tension-type headache
2.0
15.3
175
931
SPAT1212
SPAT
Extensive examination of musculoskeletal system
2.5
15.2
97
404
C01DA14
ATC
isosorbide mononitrate; oral
2.3
15.1
125
585
N06AX16
ATC
venlafaxine; oral
2.0
15.1
177
949
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.4
15.1
108
475
M53.1
ICD-10 Finland
Cervicobrachial syndrome
2.2
15.0
139
682
5790A
ICD-9 Finland
Intestinal malabsorption, Coeliac disease
32.2
14.8
19
6
C10AA05
ATC
atorvastatin; oral
1.7
14.7
326
2137
A06AD11
ATC
lactulose; oral
2.1
14.6
153
787
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
4.0
14.6
42
109
XF400
NOMESCO Finland
ECG with 12 standard connections
2.1
14.6
159
830
R4110
NOMESCO Finland
Physiotherapy
1.8
14.5
284
1798
H04.10
ICD-10 Finland
Dry eye syndrome
2.2
14.4
136
672
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.0
14.4
166
885
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.4
14.3
98
422
A02BA03
ATC
famotidine; systemic
3.6
14.3
48
139
L02
ICPC
Back symptom/complaint
2.2
14.2
130
635
R06AX27
ATC
desloratadine; oral
1.7
14.1
344
2313
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.8
14.1
229
1369
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
2.2
14.0
124
596
M01AE02
ATC
naproxen; oral, rectal
1.6
14.0
644
5075
K58
ICD-10 Finland
Irritable bowel syndrome
3.5
13.8
47
137
C07AA05
ATC
propranolol; systemic
1.8
13.8
243
1486
M02AA10
ATC
ketoprofen; topical
2.0
13.8
168
911
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
13.8
455
3300
1310
FHL
Esophagogastroscopy
24.1
13.8
19
8
5641A
ICD-9 Finland
Functional digestive disorders, not elsewhere classified, Irritable colon
24.1
13.8
19
8
UKC02
NOMESCO Finland
Cystoscopy
2.1
13.8
147
761
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.7
13.7
291
1880
XQ800
NOMESCO Finland
Prick test
2.3
13.5
105
478
M02AA07
ATC
piroxicam; topical
1.7
13.5
363
2497
J01FF01
ATC
clindamycin; systemic
1.7
13.4
284
1832
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.7
13.4
319
2126
J45
ICD-10 Finland
Asthma
2.2
13.3
122
595
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.6
13.3
448
3261
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.1
13.3
137
700
J01FA06
ATC
roxithromycin; oral
1.6
13.2
418
2993
R03AC03
ATC
terbutaline; inhalant
2.0
13.2
161
874
AA1AD
NOMESCO Finland
CT of head and brain
1.8
13.2
242
1498
U07
ICPC
Urine symptom/complaint other
2.5
12.9
85
359
R19.4
ICD-10 Finland
Change in bowel habit
3.8
12.9
39
105
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.2
12.8
111
529
N05BA01
ATC
diazepam; systemic, rectal
2.0
12.8
149
795
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.6
12.8
578
4496
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
14.2
12.8
21
15
A02BX02
ATC
sucralfate; oral
3.2
12.8
51
165
C03CA01
ATC
furosemide; systemic
1.8
12.7
251
1584
K50.9
ICD-10 Finland
Crohn disease, unspecified
4.8
12.6
28
59
R05
ICPC
Cough
1.7
12.5
269
1738
E86
ICD-10 Finland
Volume depletion
24.6
12.5
17
7
C10AA07
ATC
rosuvastatin; oral
1.7
12.4
262
1685
EB1AA, ,
SPAT
2.4
12.3
84
361
J01FA09
ATC
clarithromycin; systemic
1.6
12.3
348
2416
1300
FHL
Esophagogastroduodenoscopy (also includes staining)
9.8
12.3
24
25
H02AB07
ATC
prednisone; oral
2.0
12.2
148
800
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.6
12.2
520
3975
M03BC51
ATC
orphenadrine, combinations; systemic
1.7
12.2
288
1907
J01EA01
ATC
trimethoprim; systemic
1.7
12.2
293
1949
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
12.0
262
1697
S01GX01
ATC
cromoglicic acid; ophthalmic
1.7
11.9
243
1545
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
2.5
11.9
79
335
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
11.9
570
4465
N05CF02
ATC
zolpidem; oral
1.8
11.9
190
1125
R10.0
ICD-10 Finland
Acute abdomen
3.4
11.9
43
131
WX110, ,
SPAT
2.5
11.8
79
336
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.8
11.8
198
1189
R12
ICD-10 Finland
Heartburn
2.3
11.8
97
452
N02BE01
ATC
paracetamol; systemic, rectal
1.8
11.8
951
8430
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.0
11.6
138
741
D82
ICPC
Teeth/gum disease
1.6
11.6
413
3022
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.9
11.6
166
950
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.6
11.5
66
261
N06AB03
ATC
fluoxetine; oral
2.0
11.5
140
759
C07AB07
ATC
bisoprolol; oral
1.6
11.5
418
3072
M54.3
ICD-10 Finland
Sciatica
2.6
11.4
68
274
Z76.0
ICD-10 Finland
Issue of repeat prescription
1.7
11.4
246
1588
R07.3
ICD-10 Finland
Other chest pain
2.1
11.3
112
563
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.9
11.2
147
816
R01BA52
ATC
pseudoephedrine, combinations; oral
1.6
11.2
304
2080
JAH01
NOMESCO Finland
Laparoscopy
2.8
11.2
57
212
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.8
11.2
206
1271
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
2.7
11.1
60
230
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.9
11.1
156
887
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
2.7
11.0
60
231
L13
ICPC
Hip symptom/complaint
1.8
11.0
185
1111
J45.1
ICD-10 Finland
Nonallergic asthma
2.3
11.0
82
367
J01MA12
ATC
levofloxacin; systemic
1.8
11.0
175
1034
B01AC04
ATC
clopidogrel; oral
2.1
11.0
113
576
M01AH02
ATC
rofecoxib; oral
2.0
11.0
124
654
SFC01
NOMESCO Finland
Additional procedure necessary for restorative treatment
1.6
10.9
282
1904
R01AD12
ATC
fluticasone furoate; nasal
1.6
10.8
353
2521
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.0
10.8
47
160
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
1.9
10.8
135
737
M01AH01
ATC
celecoxib; oral
1.8
10.8
177
1055
AN1
HP
Coronary angiography
2.4
10.8
77
338
R02
ICPC
Shortness of breath/dyspnoea
1.9
10.8
134
731
R03AK07
ATC
formoterol and budesonide; inhalant
1.7
10.7
224
1430
R20.2
ICD-10 Finland
Paraesthesia of skin
2.3
10.7
82
372
N05CD07
ATC
temazepam; oral
2.0
10.7
119
625
M03BC01
ATC
orphenadrine (citrate); systemic
1.7
10.6
239
1558
J01DB01
ATC
cefalexin; oral
1.6
10.6
888
7795
A03DA02
ATC
pitofenone and analgesics; systemic
4.4
10.5
26
60
SHA02
NOMESCO Finland
Stomatognathic treatment, basic
2.2
10.5
95
460
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
3.1
10.5
44
147
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.8
10.5
52
191
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.1
10.5
109
558
K50.8
ICD-10 Finland
Other Crohn disease
4.2
10.4
27
65
N05CF01
ATC
zopiclone; oral
1.6
10.4
316
2218
JN3AD
NOMESCO Finland
Abdominal CT examination
2.1
10.4
106
539
Z2221
NOMESCO Finland
Medical doctor
1.6
10.4
289
1986
P06
ICPC
Sleep disturbance
1.9
10.3
132
726
UJF32, ,
SPAT
3.3
10.3
38
117
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.7
10.3
202
1266
M01AX17
ATC
nimesulide; oral
1.7
10.2
226
1463
M01AX01
ATC
nabumetone; oral
2.8
10.2
50
182
WZC00
NOMESCO Finland
Treatment plan or consultation
1.5
10.2
380
2790
A01
ICPC
Pain general/multiple sites
2.1
10.2
98
487
D03
ICPC
Heartburn
3.0
10.2
45
155
Z3231
NOMESCO Finland
Registered nurse
1.6
10.2
280
1917
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.9
10.1
138
775
104
Kela drug reimbursment
Thyroid insufficiency
2.3
10.1
74
328
K08.80
ICD-10 Finland
Toothache NOS
2.0
10.1
109
565
S29
ICPC
Skin symptom/complaint other
1.7
10.1
197
1233
N03AE01
ATC
clonazepam; systemic
2.5
10.1
64
266
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
1.9
10.1
130
717
R01AD58
ATC
fluticasone, combinations; nasal
1.6
10.1
274
1869
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.0
10.1
108
559
N06AB10
ATC
escitalopram; oral
1.7
10.1
233
1527
EB1SA, ,
SPAT
2.4
10.0
67
286
M54.6
ICD-10 Finland
Pain in thoracic spine
2.2
10.0
86
409
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.1
10.0
99
498
G04BD08
ATC
solifenacin; oral
2.5
10.0
65
274
R06.5
ICD-10 Finland
Mouth breathing
2.1
10.0
92
450
K59.00
ICD-10 Finland
Constipation caused by slow bowel passage (SCT)
3.8
9.9
30
81
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.2
9.9
85
404
N06AB06
ATC
sertraline; oral
1.9
9.9
136
767
H03BB01
ATC
carbimazole; oral
3.0
9.9
43
147
G04BD07
ATC
tolterodine; oral
2.7
9.9
54
209
F34.1
ICD-10 Finland
Dysthymia
2.9
9.8
47
169
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.9
9.8
136
768
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
9.8
199
1259
R03BA02
ATC
budesonide; inhalant
1.7
9.8
198
1251
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
1.9
9.7
119
645
Z01.7
ICD-10 Finland
Laboratory examination
1.8
9.7
154
907
WX002
NOMESCO Finland
Sedation and analgesia
1.7
9.7
183
1134
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.8
9.6
154
909
N39.3
ICD-10 Finland
Stress incontinence
2.2
9.6
83
395
K03.82
ICD-10 Finland
Split tooth for reasons other than trauma
1.6
9.6
235
1560
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
1.9
9.6
120
655
SFA20
NOMESCO Finland
Two-surface restoration
1.5
9.6
617
5053
U02
ICPC
Urinary frequency/urgency
1.8
9.6
155
918
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
2.5
9.6
61
254
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
3.1
9.6
39
128
X59
ICD-10 Finland
Exposure to unspecified factor
1.7
9.5
196
1243
N01
ICPC
Headache
1.8
9.5
151
889
M50.3
ICD-10 Finland
Other cervical disc degeneration
3.9
9.5
28
74
ZXE00
NOMESCO Finland
One hour or less
1.5
9.5
398
2986
V700A
ICD-9 Finland
General medical examination, Routine general medical examination at a health care facility
3.4
9.5
34
103
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.3
9.5
70
312
WX402
NOMESCO Finland
General anaesthesia
1.7
9.5
205
1319
M01AH05
ATC
etoricoxib; oral
1.5
9.4
629
5186
A07AA02
ATC
nystatin; oral
2.4
9.3
64
276
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.8
9.3
145
849
R5140
NOMESCO Finland
Monitoring the use of the aid
2.0
9.3
103
539
K59.0
ICD-10 Finland
Constipation
2.4
9.3
62
264
M54.2
ICD-10 Finland
Cervicalgia
2.1
9.3
93
469
M54
ICD-10 Finland
Dorsalgia
1.8
9.3
136
782
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.0
9.2
96
491
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
2.2
9.2
82
395
N05BE01
ATC
buspirone; oral
3.0
9.2
39
131
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.6
9.2
223
1476
N30.0
ICD-10 Finland
Acute cystitis
1.7
9.2
174
1079
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.0
9.2
108
578
G04BD12
ATC
mirabegron; oral
1.9
9.1
110
593
K02.1
ICD-10 Finland
Caries of dentine
1.5
9.1
632
5231
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
9.1
438
3374
R50.9
ICD-10 Finland
Fever, unspecified
1.8
9.1
159
963
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
3.3
9.1
33
101
A01AB04
ATC
amphotericin B; local oral
2.6
9.1
54
218
R03DC03
ATC
montelukast; oral
1.7
9.0
184
1164
M05BX04
ATC
denosumab; parenteral
2.5
9.0
57
237
K50.0
ICD-10 Finland
Crohn disease of small intestine
3.9
9.0
26
68
D13.1
ICD-10 Finland
Benign neoplasm: Stomach
3.9
9.0
26
68
R63.4
ICD-10 Finland
Abnormal weight loss
2.8
9.0
43
155
R60.0
ICD-10 Finland
Localized oedema
1.9
9.0
110
597
R11
ICD-10 Finland
Nausea and vomiting
2.0
8.9
96
497
A11
ICPC
Chest pain NOS
2.2
8.9
76
360
A28
ICPC
Limited function/disability NOS
1.8
8.9
139
814
R05FB02
ATC
cough suppressants and expectorants; systemic
1.5
8.9
359
2665
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.5
8.8
571
4651
K29.1
ICD-10 Finland
Other acute gastritis
4.7
8.8
20
43
L04AX03
ATC
methotrexate; systemic
1.9
8.8
105
564
M70.6
ICD-10 Finland
Trochanteric bursitis
1.8
8.8
135
787
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.9
8.8
121
682
H03AA01
ATC
levothyroxine sodium; systemic
1.6
8.8
237
1609
ZXD20
NOMESCO Finland
Day surgery
1.8
8.8
135
788
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.7
8.8
188
1205
A01AB09
ATC
miconazole; local oral
2.0
8.7
95
494
K29.5
ICD-10 Finland
Chronic gastritis, unspecified
3.6
8.7
28
79
B03BA03
ATC
hydroxocobalamin; parenteral
2.5
8.7
56
235
R19.8
ICD-10 Finland
Other specified symptoms and signs involving the digestive system and abdomen
4.3
8.7
22
52
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.2
8.7
71
331
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
3.4
8.7
31
94
ZXD10
NOMESCO Finland
Scheduled procedure
1.5
8.7
369
2768
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.6
8.7
233
1580
C07AB02
ATC
metoprolol; systemic
1.7
8.6
169
1057
T45
ICPC
Metabolic, Observ/health educat/advice/diet
4.6
8.6
20
44
N02AJ06
ATC
codeine and paracetamol; systemic
1.5
8.6
415
3192
M05BA07
ATC
risedronic acid; oral
3.0
8.6
37
126
SFA10
NOMESCO Finland
One-surface restoration
1.5
8.6
580
4757
N76.0
ICD-10 Finland
Acute vaginitis
2.1
8.6
83
414
UJD10, ,
SPAT
3.3
8.5
31
95
N17
ICPC
Vertigo/dizziness
1.8
8.5
124
711
J31.0
ICD-10 Finland
Chronic rhinitis
2.0
8.5
97
513
R01AD05
ATC
budesonide; nasal
2.1
8.5
85
429
M47.82
ICD-10 Finland
Other spondylosis, cervical region
2.7
8.4
46
178
T78.3
ICD-10 Finland
Angioneurotic oedema
4.3
8.4
21
49
R60.9
ICD-10 Finland
Oedema, unspecified
2.5
8.4
53
220
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.5
8.4
51
208
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
1.8
8.4
120
684
ZXD05
NOMESCO Finland
Urgent procedure
1.5
8.4
297
2141
U01
ICPC
Dysuria/painful urination
2.0
8.4
91
473
K20
ICD-10 Finland
Oesophagitis
4.5
8.4
20
45
M53.0
ICD-10 Finland
Cervicocranial syndrome
1.9
8.3
103
560
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.6
8.3
256
1790
7879X
ICD-9 Finland
Symptoms involving digestive system, Other symptoms involving digestive system
9.5
8.3
16
17
1370
FHL
Colonoscopy, whole colon
14.6
8.2
13
9
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
2.1
8.2
81
407
K21
ICD-10 Finland
Gastro-oesophageal reflux disease
2.2
8.2
71
339
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.3
8.2
60
267
R00.2
ICD-10 Finland
Palpitations
2.0
8.1
88
457
B60
ICPC
Blood and Immunity, Result test/procedure
4.8
8.1
18
38
R4120
NOMESCO Finland
Occupational therapy
2.2
8.1
66
307
M51.9
ICD-10 Finland
Intervertebral disc disorder, unspecified
4.1
8.1
22
55
M05BA04
ATC
alendronic acid; oral
2.0
8.1
87
451
A10AB05
ATC
insulin aspart; parenteral
2.2
8.1
69
328
5301A
ICD-9 Finland
Diseases of oesophagus, Oesophagitis[OESOPHAGITIS REFLUENS]
9.0
8.0
16
18
R13
ICD-10 Finland
Dysphagia
2.2
8.0
67
315
J37.0
ICD-10 Finland
Chronic laryngitis
2.8
8.0
40
148
K02.2
ICD-10 Finland
Caries of cementum
2.5
8.0
49
201
G03CA04
ATC
estriol; systemic, vaginal
2.1
8.0
71
343
R06AE09
ATC
levocetirizine; oral
1.7
8.0
160
1007
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
2.3
8.0
61
277
ZXE10
NOMESCO Finland
More than one and less than three hours
1.5
7.9
337
2518
E66.00
ICD-10 Finland
Metabolic syndrome
2.5
7.9
49
202
R06AX22
ATC
ebastine; oral
1.6
7.9
181
1178
D07AC13
ATC
mometasone; topical
1.5
7.9
284
2051
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.7
7.9
141
859
A03FA01
ATC
metoclopramide; systemic, rectal
1.6
7.9
220
1502
N30
ICD-10 Finland
Cystitis
1.9
7.9
93
498
D07AA02
ATC
hydrocortisone; topical
1.7
7.9
158
994
SFA30
NOMESCO Finland
Three-surface restoration
1.5
7.9
407
3159
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.7
7.8
143
876
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
1.9
7.8
94
506
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
3.3
7.8
29
90
G04BD11
ATC
fesoterodine; oral
3.3
7.8
29
90
E0000UV, ,
ATC
1.4
7.8
433
3402
I25.2
ICD-10 Finland
Old myocardial infarction
2.6
7.8
44
173
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.8
7.8
118
685
M75
ICD-10 Finland
Shoulder lesions
2.4
7.8
51
216
R03BA05
ATC
fluticasone; inhalant
1.6
7.7
195
1299
J01DA09
ATC
[U] cefadroxil
1.5
7.7
266
1902
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.5
7.7
293
2138
N02BF02
ATC
pregabalin; oral
2.3
7.7
60
274
D07AB02
ATC
hydrocortisone butyrate; topical
1.5
7.7
301
2212
J45.8
ICD-10 Finland
Mixed asthma
2.8
7.6
36
129
A62
ICPC
General and Unspecified, Administrative procedure
3.1
7.6
31
102
M01AX05
ATC
glucosamine; oral
1.7
7.6
166
1067
R32
ICD-10 Finland
Unspecified urinary incontinence
3.0
7.6
33
113
D62
ICPC
Digestive, Administrative procedure
11.9
7.6
13
11
L01BA01
ATC
methotrexate; systemic
2.6
7.6
42
164
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
7.6
769
6724
I84.9
ICD-10 Finland
Unspecified hemorrhoids without complication
2.5
7.6
45
182
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
7.5
217
1491
R05
ICD-10 Finland
Cough
1.6
7.5
216
1483
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.3
7.5
53
232
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
2.2
7.5
63
297
R00.0
ICD-10 Finland
Tachycardia, unspecified
2.4
7.5
48
201
R52.2
ICD-10 Finland
Other chronic pain
2.6
7.5
42
165
T78.4
ICD-10 Finland
Allergy, unspecified
2.3
7.5
58
265
C10AA01
ATC
simvastatin; oral
1.5
7.4
289
2117
XF402
NOMESCO Finland
ECG with work load test
2.0
7.4
83
436
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.0
7.4
77
394
J01AA04
ATC
lymecycline; systemic
1.7
7.4
146
913
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.6
7.4
171
1114
E83.50
ICD-10 Finland
Hypercalcemia
13.5
7.4
12
9
S21
ICPC
Skin texture symptom/complaint
1.7
7.4
139
859
S13.4
ICD-10 Finland
Sprain and strain of cervical spine
2.4
7.4
49
209
R15
ICD-10 Finland
Faecal incontinence
2.9
7.4
33
115
D07AC01
ATC
betamethasone; topical
1.5
7.3
341
2586
R51
ICD-10 Finland
Headache
2.1
7.3
66
320
LCA06
NOMESCO Finland
Biopsy of endometrium
1.8
7.3
116
682
JBC01
NOMESCO Finland
Laparoscopic gastro-oesophageal antireflux operation
3.6
7.3
23
64
E78.0
ICD-10 Finland
Pure hypercholesterolaemia
1.6
7.3
168
1094
H53.1
ICD-10 Finland
Subjective visual disturbances
2.1
7.3
66
321
WX100
NOMESCO Finland
Conjunctival surface anesthesia
1.8
7.3
102
578
P01BA02
ATC
hydroxychloroquine; oral
1.9
7.3
86
461
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
2.7
7.3
39
150
M54.1
ICD-10 Finland
Radiculopathy
2.6
7.2
40
156
M81.9
ICD-10 Finland
Osteoporosis, unspecified
2.5
7.2
44
180
H92.0
ICD-10 Finland
Otalgia
2.0
7.2
74
377
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.0
7.2
83
441
G04CA01
ATC
alfuzosin; oral
2.0
7.2
82
434
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.7
7.2
132
811
5645A
ICD-9 Finland
Functional digestive disorders, not elsewhere classified, Functional diarrhoea
20.2
7.1
10
5
7819X
ICD-9 Finland
Symptoms involving nervous and musculoskeletal systems, Other symptoms involving nervous and musculoskeletal systems[SYMPTOMATA ALIA SYSTEMATIS NERVORUM ET MUSCULOSCEL]
8.0
7.1
15
19
A10BK01
ATC
dapagliflozin; oral
2.3
7.1
55
251
FN1AT
NOMESCO Finland
Endovascular dilatation of coronary arteries (PTCA)
2.8
7.1
34
123
K50.1
ICD-10 Finland
Crohn disease of large intestine
5.7
7.1
19
34
M01AB55
ATC
diclofenac, combinations; oral
2.1
7.1
65
318
WX110
NOMESCO Finland
Infiltration anesthesia
1.4
7.0
749
6557
R03BB04
ATC
tiotropium bromide; inhalant
1.9
7.0
87
474
D02
ICPC
Abdominal pain epigastric
2.1
7.0
67
333
FB1AD
NOMESCO Finland
CT examination of arteria pulmonalis
3.4
7.0
24
71
E03.89
ICD-10 Finland
Other specified hypothyroidism
2.6
7.0
40
159
D64.9
ICD-10 Finland
Anaemia, unspecified
1.9
7.0
86
468
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
1.9
7.0
95
534
L50.0
ICD-10 Finland
Allergic urticaria
2.8
6.9
33
119
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
2.5
6.9
43
178
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
1.8
6.9
100
573
N02BF01
ATC
gabapentin; oral
2.0
6.9
77
405
K57.9
ICD-10 Finland
Diverticular disease of intestine, part unspecified, without perforation or abscess
3.2
6.9
27
87
T90
ICPC
Diabetes non-insulin dependent
1.6
6.9
171
1135
M01AC06
ATC
meloxicam; systemic, rectal
1.4
6.8
341
2615
SPAT1305
SPAT
Counselling and guidance related to physical exercise
1.9
6.8
89
493
0093A
ICD-9 Finland
Ill-defined intestinal infections, Diarrhoea of presumed infectious origin
3.8
6.8
20
53
103
Kela drug reimbursment
Diabetes, insulin-treated
1.5
6.8
203
1404
M48.0
ICD-10 Finland
Spinal stenosis
1.8
6.8
108
636
R05DA20
ATC
opium alkaloids and derivatives - combinations
1.5
6.7
254
1845
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
2.2
6.7
57
270
X57
ICD-10 Finland
Unspecified privation
3.2
6.7
26
83
A10BH01
ATC
sitagliptin; oral
2.0
6.7
70
359
A09AA02
ATC
multienzymes (lipase, protease etc.); oral
3.3
6.7
24
73
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.9
6.7
78
416
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.1
6.7
65
325
R4110, ,
SPAT
1.9
6.7
85
467
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
3.0
6.7
28
94
E66
ICD-10 Finland
Obesity
2.2
6.6
56
265
J20
ICD-10 Finland
Acute bronchitis
1.8
6.6
102
595
R21
ICPC
Throat symptom/complaint
1.5
6.6
243
1755
R06AX26
ATC
fexofenadine; oral
1.9
6.6
79
425
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
1.9
6.6
89
498
J01FA01
ATC
erythromycin; systemic
1.6
6.6
143
916
M81.5
ICD-10 Finland
Idiopathic osteoporosis
7.9
6.6
14
18
SAA02
NOMESCO Finland
Basic examination of mouth
1.4
6.6
717
6261
A97
ICPC
No disease
1.6
6.6
182
1236
L95
ICPC
Osteoporosis
2.7
6.6
35
134
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.7
6.6
118
719
5355X
ICD-9 Finland
Gastritis and duodenitis, Unspecified gastritis and gastroduodenitis
12.3
6.6
11
9
00919
ICD-8 Finland
Diarrhoeal disease, Diarrhoea
12.3
6.6
11
9
K29.7
ICD-10 Finland
Gastritis, unspecified
2.6
6.6
36
140
F61.0
ICD-10 Finland
Mixed personality disorders
3.4
6.6
23
69
SXC05
NOMESCO Finland
Other oral or dental procedure
1.9
6.6
82
448
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
2.5
6.6
39
158
I20.99
ICD-10 Finland
Angina pectoris, unspecified
2.3
6.6
48
214
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
2.4
6.6
45
195
X58
ICD-10 Finland
Exposure to other specified factors
1.6
6.5
151
984
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
1.8
6.5
94
538
N05AF03
ATC
chlorprothixene; systemic
2.9
6.5
29
101
J01MA01
ATC
ofloxacin; systemic
1.9
6.5
77
414
TDM10
NOMESCO Finland
Puncture of maxillary antrum
2.4
6.5
44
190
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
2.2
6.5
53
248
R06AX13
ATC
loratadine; oral
1.6
6.5
160
1060
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
2.4
6.5
43
184
WX290, ,
SPAT
2.4
6.4
42
178
T36
ICD-10 Finland
Poisoning by systemic antibiotics
2.3
6.4
47
210
Z01.4
ICD-10 Finland
Gynaecological examination (general)(routine)
1.5
6.4
193
1337
A48
ICPC
General and Unspecified, Clarification/discussion RFE/demand
2.0
6.4
72
380
I20.09
ICD-10 Finland
Unstable angina
2.4
6.4
41
173
B37.3
ICD-10 Finland
Candidiasis of vulva and vagina
3.1
6.3
25
81
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
2.3
6.3
46
205
PD5AD
NOMESCO Finland
CT of aorta
3.5
6.3
21
61
C10AA04
ATC
fluvastatin; oral
2.1
6.3
61
305
L08
ICPC
Shoulder symptom/complaint
1.5
6.3
200
1401
5621A
ICD-9 Finland
Diverticula of intestine, Colon[DIVERTICULOSIS COLI]
9.3
6.3
12
13
P29
ICPC
Psychological sympt/compl other
1.8
6.3
85
477
M01AG02
ATC
tolfenamic acid; oral, rectal
1.6
6.3
155
1026
EBA05
NOMESCO Finland
Complicated extraction of tooth
1.5
6.3
208
1471
105
Kela drug reimbursment
Adrenal cortical hypofunction
+∞
6.3
6
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.1
6.3
60
299
S22
ICPC
Nail symptom/complaint
2.0
6.2
62
313
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
2.1
6.2
56
272
N06AX22
ATC
agomelatine; oral
2.9
6.2
28
98
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
1.8
6.2
93
538
A10AE04
ATC
insulin glargine; parenteral
1.9
6.2
73
391
A10AC01
ATC
insulin (human); parenteral
1.9
6.2
71
377
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
2.4
6.2
41
175
N06AB05
ATC
paroxetine; oral
2.0
6.2
61
307
R41.3
ICD-10 Finland
Other amnesia
2.9
6.2
27
93
I20.89
ICD-10 Finland
Other angina pectoris unspecified coronary artery status
2.9
6.2
27
93
L04AX01
ATC
azathioprine; systemic
2.3
6.2
43
188
F51.0
ICD-10 Finland
Nonorganic insomnia
1.6
6.2
169
1146
I10
ICD-10 Finland
Essential (primary) hypertension
1.4
6.2
475
3908
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
1.9
6.2
71
378
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
3.4
6.2
21
62
T29
ICPC
Endocr/metab/nutr sympt/compl other
3.3
6.2
22
67
R03AK08
ATC
formoterol and beclometasone; inhalant
2.2
6.1
49
227
SPAT1262
SPAT
Handing over of treatment supplies
1.6
6.1
136
878
SPAT1342
SPAT
Referral to specialised care
3.8
6.1
18
48
4930A
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA SINE EXACERBATIONE]
4.1
6.1
16
39
A04
ICPC
Weakness/tiredness general
1.6
6.1
144
943
ZXA00
NOMESCO Finland
Right side
1.5
6.1
230
1669
D48
ICPC
Digestive, Clarification/discussion RFE/demand
12.6
6.1
10
8
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.4
6.1
303
2316
I20.90
ICD-10 Finland
Angina pectoris, unspecified
2.9
6.1
27
94
S06.0
ICD-10 Finland
Concussion
1.7
6.1
110
673
H3603, E103,
ICD-10 Finland
8.6
6.1
12
14
R48
ICPC
Respiratory, Clarification/discussion RFE/demand
10.1
6.0
11
11
SDA03
NOMESCO Finland
Periodontal treatment
1.4
6.0
394
3153
U71
ICPC
Cystitis/urinary infection other
1.9
6.0
71
381
SFA40
NOMESCO Finland
Restoration involving the entire crown of the tooth
1.5
6.0
198
1397
L86
ICPC
Back syndrome with radiating pain
2.1
6.0
57
283
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
297
1179
3.06
54.51
2.5
2.4
109.64
117.19
ug/g
0.15
237
919
413
2210
2.37
39.67
1.5
1.3
1.36
1.82
u/ml
0.43
89
565
551
3463
2.15
34.48
6.8
5.1
1.22
1.22
mmol/l
0.01
502
3146
354
1896
2.26
32.81
1.6
1.4
2.13
2.26
g/l
0.66
180
1143
551
3552
2.07
31.28
2.8
2.2
77.47
76.77
nmol/l
0.22
502
3212
584
3862
2.06
30.74
7.4
5.5
1.22
1.22
mmol/l
0.20
505
3281
839
6407
2.20
29.22
8.1
6.6
76.07
77.89
u/l
0.71
798
5999
610
4147
2.02
29.19
5.3
5.7
10.14
10.95
umol/l
1.51
578
3919
85
227
3.97
28.37
1.4
1.4
303.86
307.81
ug/g
0.06
44
128
507
3260
2.01
28.07
4.6
4.3
36.54
36.14
g/l
0.95
466
3020
835
6432
2.14
27.42
5.1
3.9
11.11
10.95
mm/h
0.13
790
5971
485
3114
1.98
26.56
2.3
1.8
98.74
96.78
pmol/l
0.39
266
1599
131
500
2.83
24.58
2.0
1.5
—
—
—
0
0
604
4262
1.90
24.14
6.8
5.8
29.06
29.16
%
0.08
563
4011
597
4217
1.88
23.58
6.6
5.6
56.23
56.29
%
0.04
556
3966
676
5021
1.86
22.23
9.3
8.4
4.12
3.96
e9/l
0.90
574
4405
328
1963
1.94
21.07
4.4
3.7
92.41
92.53
%
0.03
318
1903
390
2481
1.87
20.73
2.7
2.2
52.44
62.08
u/l
3.10
363
2287
744
5761
1.85
20.67
5.6
4.1
4217.27
2941.86
e6/l
0.17
11
72
220
1186
2.06
18.77
3.3
2.7
2.05
2.84
e6/l
0.67
95
632
179
892
2.20
18.73
2.3
2.8
5.40
7.36
umol/l
1.65
143
756
125
534
2.51
18.62
1.1
1.0
—
—
—
0
0
428
2882
1.78
18.39
4.4
3.3
40.35
108.36
e6/l
1.71
273
1977
102
399
2.71
18.16
1.2
1.1
—
1.03
—
0
6
175
876
2.18
18.07
4.5
5.2
1.04
1.07
mmol/l
0.61
160
809
420
2839
1.76
17.63
3.9
2.9
—
—
—
0
0
325
2039
1.83
17.52
2.7
2.1
2.83
2.97
mg/l
0.54
284
1739
230
1294
1.98
17.29
3.1
2.5
0.57
1.07
e6/l
4.19
104
736
85
313
2.86
16.96
1.9
1.7
—
—
—
0
0
151
749
2.17
15.87
2.6
2.3
39.04
100.65
u/l
0.46
125
628
195
1069
2.00
15.68
3.8
3.7
0.82
0.83
mmol/l
0.34
184
1002
956
8291
1.99
15.62
6.3
4.5
1.74
1.86
mu/l
2.60
905
7670
399
2737
1.71
15.42
2.8
3.2
2.36
2.36
mmol/l
0.21
345
2423
187
1023
1.99
15.09
2.7
2.1
2.44
2.38
g/l
0.84
168
947
841
7040
1.76
15.01
5.1
3.8
14.85
14.61
pmol/l
2.13
795
6455
229
1345
1.88
14.95
1.8
1.7
1111.25
1153.70
nmol/l
0.31
173
1021
201
1135
1.94
14.77
2.7
2.1
13.69
13.72
umol/l
0.01
185
1064
175
943
2.01
14.71
2.8
2.2
22.13
23.51
%
0.53
151
831
606
4671
1.64
14.68
5.7
4.1
6.58
6.47
mmol/l
0.61
565
4290
538
4060
1.62
13.94
3.4
2.6
95.86
99.54
ug/l
0.21
505
3775
73
276
2.76
13.87
1.2
1.2
—
—
—
0
0
401
2821
1.65
13.73
4.2
2.9
32.38
42.74
ng/l
0.28
237
1706
1005
8976
2.07
13.55
17.8
11.3
20.23
21.63
mg/l
0.76
831
6876
72
274
2.74
13.51
1.3
1.2
—
—
—
0
0
277
1777
1.74
13.33
1.6
1.5
20.28
21.13
nmol/l
0.49
244
1518
325
2179
1.69
13.31
3.6
2.8
0.21
0.40
e6/l
2.02
227
1654
140
721
2.07
13.27
2.2
2.1
387.10
364.18
nmol/l
0.56
123
671
389
2734
1.64
13.27
3.2
3.0
30.22
30.69
u/l
0.11
368
2597
456
3335
1.62
13.23
14.7
11.5
1.21
1.20
inr
0.09
112
1009
347
2372
1.67
13.18
3.6
2.9
29.88
104.91
e6/l
1.70
250
1821
220
1330
1.81
12.94
4.0
3.1
136.28
571.57
ng/l
2.67
153
901
294
1934
1.70
12.86
2.5
2.3
327.57
5407.53
umol/l
6.29
260
1705
134
698
2.04
12.30
2.7
2.3
0.24
0.22
g/l
2.19
122
658
286
1901
1.68
11.91
2.9
2.9
1537.23
1051.32
ng/l
0.78
242
1564
104
500
2.19
11.75
3.7
2.9
4.53
4.53
pmol/l
0.02
87
439
284
1892
1.67
11.70
1.8
1.8
1.46
1.06
mg/l
0.95
205
1393
316
2164
1.64
11.68
2.3
1.9
142.16
252.71
u/l
1.62
297
2044
555
4341
1.55
11.54
4.1
3.3
0.00
0.00
estimate
0.50
89
885
715
5921
1.56
11.45
3.6
2.9
41.04
41.92
u/l
0.15
681
5582
121
626
2.04
11.30
12.3
8.4
95.02
95.74
%
0.47
114
606
114
577
2.09
11.29
12.9
8.5
120.55
121.56
g/l
0.20
107
563
133
716
1.97
11.11
11.4
7.8
0.68
1.14
mmol/l
0.53
105
561
137
748
1.95
10.98
2.6
2.7
1.65
1.71
%
0.29
118
674
557
4399
1.52
10.83
4.1
3.3
0.02
0.01
estimate
0.30
83
826
552
4356
1.52
10.74
5.8
4.5
0.00
0.00
estimate
0.50
86
841
294
2016
1.62
10.67
2.4
2.2
—
—
—
0
0
144
810
1.89
10.54
11.4
6.3
104.59
104.68
mmol/l
0.09
144
810
129
722
1.89
9.58
11.4
7.8
4.99
5.14
kpa
1.15
123
688
233
1546
1.64
9.54
1.4
1.3
29.84
30.24
iu/ml
0.01
55
490
129
723
1.89
9.53
11.4
7.7
12.05
12.80
kpa
0.85
123
690
213
1427
1.61
8.30
3.0
2.8
2.44
2.44
mmol/l
0.44
178
1247
916
8247
1.58
8.28
15.1
10.0
85.79
85.54
ml/min/173m2
0.12
746
6728
983
9010
1.70
8.20
19.4
12.1
139.58
139.71
mmol/l
0.91
964
8742
985
9037
1.70
8.14
19.5
12.2
3.94
3.94
mmol/l
0.43
964
8750
98
542
1.88
7.55
3.4
3.2
79.32
77.09
ng/l
0.11
82
478
90
484
1.93
7.54
4.6
3.4
1.94
1.85
mmol/l
0.09
72
369
159
1015
1.66
7.48
4.9
3.8
30.88
32.35
%
0.95
119
716
19
32
6.02
7.39
1.2
1.3
—
—
—
0
0
168
1096
1.63
7.25
1.9
1.7
1.40
1.40
%
0.06
147
1000
863
7755
1.48
7.04
6.1
4.6
39.58
38.45
mmol/mol
2.71
815
7207
1022
9547
1.73
6.92
12.0
8.8
26.17
25.63
u/l
0.32
996
9216
40
161
2.54
6.82
1.2
1.3
—
—
—
0
0
40
161
2.54
6.82
1.2
1.3
—
—
—
0
0
302
2274
1.45
6.66
3.6
3.0
7.70
7.73
mmol/l
0.04
271
1964
213
1498
1.52
6.60
1.4
1.2
19.79
11.44
u/ml
0.36
70
600
162
1071
1.60
6.60
2.0
2.2
30.27
29.46
s
0.82
155
1033
284
2117
1.46
6.59
1.7
1.6
1.45
1.32
mmol/l
1.30
256
1791
175
1179
1.57
6.58
2.0
1.7
—
—
—
0
0
61
301
2.09
6.51
1.3
1.4
—
—
—
0
0
231
1661
1.49
6.42
2.5
2.3
5.88
7.41
e6/l
0.74
203
1486
38
154
2.52
6.40
3.1
2.4
134.10
130.27
g/l
0.57
29
115
13
16
8.20
6.34
1.1
1.2
—
—
—
0
0
33
126
2.67
6.26
2.1
1.8
4.74
5.06
mmol/24h
0.19
28
115
98
578
1.76
6.15
1.2
1.4
—
—
—
0
0
40
170
2.40
6.11
1.6
1.2
—
—
—
0
0
30
113
2.70
5.86
1.3
1.2
—
—
—
0
0
49
235
2.13
5.66
1.2
1.2
6.10
8.86
u/ml
—
6
45
272
2071
1.41
5.51
1.8
1.6
—
—
—
0
0
92
551
1.73
5.49
2.4
2.0
12.51
12.47
nmol/l
0.02
83
499
48
232
2.12
5.45
1.2
1.2
10.34
2.17
u/ml
—
5
26
39
176
2.26
5.24
1.4
1.5
—
—
—
0
0
478
4011
1.33
5.18
2.7
2.4
—
—
—
0
0
120
787
1.59
5.05
1.8
1.6
—
—
—
0
0
912
8439
1.42
5.03
4.9
3.9
5.90
5.75
mmol/l
2.86
844
7698
52
269
1.98
4.95
1.2
1.1
3.96
6.42
u/ml
—
8
42
48
242
2.03
4.90
1.4
1.7
2.72
2.98
g/l
1.16
42
223
120
793
1.57
4.90
1.8
1.7
—
—
—
0
0
44
215
2.09
4.88
1.5
1.7
0.45
1.02
g/l
0.83
39
194
253
1943
1.39
4.82
3.8
3.1
313.77
355.03
mg/l
0.05
179
1234
63
357
1.81
4.57
5.1
3.7
24.74
24.84
mmol/l
0.11
63
345
69
406
1.74
4.42
2.1
1.5
—
—
—
0
0
28
118
2.41
4.42
1.4
1.4
—
—
—
0
0
61
347
1.80
4.38
1.4
1.2
0.29
1.33
u/ml
—
7
24
722
6502
1.31
4.37
3.8
3.3
—
—
—
0
0
48
253
1.94
4.36
1.4
1.7
3.76
3.61
g/l
0.24
42
234
48
253
1.94
4.36
1.4
1.7
7.28
7.34
g/l
0.08
42
234
48
253
1.94
4.36
1.4
1.7
—
—
—
0
0
261
2048
1.36
4.31
4.5
3.5
9.88
6.89
mg/mmol
0.53
173
1268
33
153
2.19
4.21
1.2
1.0
5.13
1.69
u/ml
1.18
18
72
39
196
2.03
4.06
2.1
1.7
4.50
5.73
iu/l
0.33
18
60
15
47
3.22
4.06
2.9
2.5
36760.80
38031.91
ug/l
0.12
15
47
12
26
4.65
4.06
2.3
2.3
186.67
190.85
u/l
0.12
12
26
921
8621
1.37
4.04
4.6
3.8
4.67
4.76
mmol/l
2.10
872
8051
64
379
1.73
4.03
4.3
4.9
23.96
24.01
mmol/l
0.07
59
370
40
204
2.00
4.01
1.4
1.6
38.69
37.84
g/l
0.38
34
185
933
8756
1.37
3.99
5.1
4.1
2.77
2.85
mmol/l
1.90
879
8108
62
367
1.73
3.92
2.1
1.8
—
—
—
0
0
243
1912
1.35
3.91
4.1
3.6
1.02
1.02
kg/l
0.31
37
269
52
293
1.81
3.88
1.4
1.9
—
—
—
0
0
35
172
2.07
3.88
1.3
1.2
—
—
—
0
0
29
133
2.21
3.82
2.1
2.3
123.51
74.95
ug/min
0.26
24
79
13
33
3.97
3.80
1.4
1.2
—
—
—
0
0
13
33
3.97
3.80
1.4
1.2
—
—
—
0
0
93
616
1.56
3.79
1.3
1.3
239.99
222.73
u/ml
0.09
87
571
43
231
1.90
3.73
1.7
3.6
188.40
169.12
%
0.66
43
220
97
652
1.53
3.71
4.1
4.1
1.42
1.80
mmol/l
0.66
84
530
10
20
5.03
3.69
1.8
1.3
94.70
82.00
nmol/24h
—
10
20
81
524
1.59
3.66
2.1
2.3
3.76
6.68
ug/l
2.47
67
458
97
654
1.53
3.66
4.1
4.0
5.84
5.83
kpa
0.04
92
630
12
30
4.03
3.60
1.2
1.0
—
—
—
0
0
15
51
2.97
3.58
1.1
1.6
13.50
6.98
u/l
—
10
45
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
35
180
1.97
3.46
2.7
3.9
0.41
0.36
u/ml
0.40
13
98
43
238
1.84
3.43
1.3
1.7
9.55
10.73
g/l
1.07
37
217
911
8575
1.32
3.38
4.6
3.7
1.45
1.51
mmol/l
3.10
857
7963
195
1517
1.34
3.36
2.4
2.2
—
—
—
0
0
41
225
1.85
3.36
2.6
2.9
—
—
—
0
0
210
1653
1.33
3.35
1.8
1.6
48864060.48
28983856.11
pmol/l
0.16
176
1387
106
747
1.46
3.25
3.2
4.3
224.60
237.42
u/l
0.87
98
708
178
1373
1.35
3.24
2.3
2.1
—
—
—
0
0
878
8244
1.29
3.17
4.1
3.4
1.32
1.24
mmol/l
2.45
817
7608
105
743
1.46
3.16
2.0
1.8
—
—
—
0
0
84
571
1.51
3.08
3.3
3.5
4.81
4.64
kpa
0.26
79
551
82
558
1.51
3.00
1.6
2.4
66.38
67.07
g/l
0.34
75
513
123
905
1.40
3.00
2.2
2.0
—
—
—
0
0
11
31
3.57
2.99
1.3
1.4
—
—
—
0
0
18
75
2.42
2.98
1.3
1.2
—
—
—
0
0
29
148
1.98
2.97
1.4
2.2
1.03
0.79
nmol/l
0.49
21
125
1057
10236
1.50
2.89
25.8
16.7
259.29
255.75
e9/l
0.92
1029
9978
1057
10243
1.49
2.80
25.7
16.6
4.47
4.51
e12/l
2.34
1024
9961
15
59
2.56
2.79
1.5
1.7
7.11
7.55
ug/l
0.07
15
51
1057
10244
1.49
2.79
25.9
16.6
6.67
6.61
e9/l
0.40
1023
9956
10
28
3.59
2.78
1.3
1.4
—
—
—
0
0
36
203
1.80
2.76
1.4
1.5
—
—
—
0
0
845
7944
1.25
2.74
20.2
13.4
15.12
14.67
%
1.20
837
7799
1057
10250
1.48
2.71
25.9
16.8
133.73
135.16
g/l
3.00
1044
10100
46
281
1.66
2.68
1.4
1.6
1.16
1.19
g/l
0.23
39
264
12
43
2.81
2.65
1.0
1.2
—
—
—
0
0
1055
10233
1.46
2.63
26.5
16.7
39.69
40.15
%
1.70
1009
9636
20
93
2.17
2.62
1.1
1.3
—
—
—
0
0
66
443
1.52
2.61
1.5
1.4
—
—
—
0
0
10
30
3.35
2.60
1.4
1.2
—
—
—
0
0
10
30
3.35
2.60
1.4
1.2
—
—
—
0
0
25
128
1.97
2.56
1.2
1.4
—
—
—
0
0
44
269
1.66
2.56
1.4
1.6
0.24
0.24
g/l
0.07
36
254
42
254
1.68
2.55
1.7
3.4
92.14
91.48
%
0.07
42
245
50
317
1.60
2.53
2.3
1.8
—
—
—
0
0
26
136
1.93
2.52
1.2
1.2
3.92
3.78
u/ml
0.04
12
58
46
287
1.63
2.49
1.6
1.6
0.08
0.06
iu/ml
—
10
44
40
241
1.68
2.47
1.6
1.6
38.20
40.17
nmol/l
0.30
40
234
17
76
2.26
2.45
1.1
1.0
—
—
—
0
0
58
386
1.53
2.40
1.4
1.3
240.57
241.99
miu/ml
0.01
28
193
16
73
2.21
2.21
1.2
1.1
—
122.00
—
0
10
95
711
1.37
2.15
1.3
1.2
117.27
139.11
iu/ml
0.29
32
288
22
116
1.91
2.12
1.1
1.2
128.68
113.44
%
1.06
22
108
31
184
1.70
2.06
2.4
1.6
4937.90
9607.92
e6/l
1.66
21
132
16
77
2.09
1.97
3.5
3.7
15.27
77.61
u/ml
—
8
22
21
112
1.89
1.97
1.8
1.3
—
—
—
0
0
21
112
1.89
1.97
1.8
1.3
—
—
—
0
0
21
112
1.89
1.97
1.8
1.3
—
—
—
0
0
10
39
2.58
1.94
1.1
4.6
12862.30
67.14
mg/l
—
10
29
9
33
2.74
1.93
2.8
2.5
—
—
—
0
0
21
113
1.87
1.92
1.8
1.3
—
—
—
0
0
24
135
1.79
1.92
1.2
1.2
1.78
2.00
u/ml
—
9
44
14
65
2.17
1.88
1.8
1.2
—
—
—
0
0
21
114
1.86
1.88
1.8
1.3
—
—
—
0
0
15
72
2.10
1.87
1.4
2.4
—
—
—
0
0
19
100
1.92
1.86
1.2
1.4
—
—
—
0
0
55
385
1.45
1.84
6.3
7.7
24.32
24.55
mmol/l
0.17
50
368
14
66
2.14
1.82
1.8
1.3
—
—
—
0
0
69
510
1.38
1.72
2.6
2.2
4669.95
4082.36
u/l
0.07
24
211
20
113
1.78
1.61
1.8
1.3
—
—
—
0
0
196
1673
1.21
1.59
4.6
4.5
1.47
3.01
ug/l
1.96
185
1501
22
129
1.72
1.57
1.1
1.1
—
—
—
0
0
20
114
1.77
1.57
1.1
1.4
—
—
—
0
0
41
282
1.47
1.54
1.5
1.2
—
—
—
0
0
22
130
1.71
1.53
1.4
1.5
7.18
7.33
mmol/l
0.10
22
115
32
209
1.55
1.52
1.8
1.4
—
—
—
0
0
5
15
3.34
1.52
1.0
1.5
1.64
3.03
mmol/l
—
5
15
18
101
1.79
1.49
2.4
2.3
48.00
22.68
mg/l
—
5
33
17
94
1.82
1.47
2.5
2.9
20.35
20.55
nmol/l
0.03
17
89
5
16
3.13
1.44
1.0
1.6
—
—
—
0
0
13
66
1.98
1.43
4.4
2.1
—
—
—
0
0
26
165
1.59
1.41
1.1
1.1
—
—
—
0
0
68
521
1.32
1.39
1.4
1.4
28.51
24.68
iu/l
0.41
52
435
12
60
2.01
1.38
1.2
3.3
—
—
—
0
0
22
135
1.64
1.36
4.5
2.3
17.69
16.56
%
1.15
16
62
41
290
1.43
1.36
2.2
1.7
—
—
—
0
0
5
17
2.95
1.36
1.0
1.2
4.78
5.38
nmol/l
—
5
17
24
151
1.60
1.35
1.6
1.6
—
—
—
0
0
53
393
1.37
1.35
1.5
1.6
3.32
3.02
mg/l
0.16
43
282
17
98
1.75
1.31
1.1
1.4
—
—
—
0
0
24
153
1.58
1.29
2.0
1.7
—
—
—
0
0
16
91
1.77
1.29
1.1
1.2
87.19
93.51
%
0.59
16
84
15
84
1.80
1.27
1.1
1.2
—
—
—
0
0
8
36
2.23
1.24
2.4
1.7
—
—
—
0
0
8
36
2.23
1.24
2.4
1.7
—
—
—
0
0
8
36
2.23
1.24
1.1
1.4
—
—
—
0
0
9
45
2.01
1.23
1.1
1.3
—
—
—
0
0
8
37
2.17
1.21
1.1
1.4
—
—
—
0
0
39
281
1.40
1.20
1.2
1.1
—
—
—
0
0
6
26
2.31
1.19
1.2
1.1
88.67
93.58
%
—
6
26
27
392
0.68
1.17
1.4
1.5
—
—
—
0
0
28
190
1.49
1.17
1.5
1.6
—
—
—
0
0
10
50
2.01
1.16
1.0
1.4
—
1282.00
—
0
5
87
708
1.25
1.16
3.4
4.1
3.97
27.25
ug/l
1.32
70
577
93
763
1.24
1.15
3.5
2.8
—
—
—
0
0
5
20
2.51
1.15
1.0
1.7
—
—
—
0
0
5
20
2.51
1.15
1.6
2.2
14.30
14.61
umol/l
—
5
20
24
158
1.53
1.15
1.5
1.7
—
—
—
0
0
27
183
1.49
1.14
1.3
1.3
262.74
233.09
u/ml
0.28
19
110
8
40
2.01
1.12
1.4
1.6
—
—
—
0
0
28
195
1.45
1.05
1.3
1.3
—
—
—
0
0
28
195
1.45
1.05
1.2
1.7
571.48
730.55
e6/l
0.08
23
157
28
195
1.45
1.05
1.2
1.7
1.65
8.18
e6/l
2.73
23
152
13
75
1.74
1.03
4.5
2.1
32.00
31.45
pg
0.20
13
75
27
188
1.45
1.02
3.0
3.4
27.37
25.26
mg/l
0.06
12
117
41
308
1.34
1.01
1.4
1.5
9.94
9.08
u/l
0.17
30
246
201
1791
1.15
1.01
1.5
1.4
—
—
—
0
0
9
49
1.84
0.98
2.7
2.1
—
—
—
0
0
65
523
1.26
0.98
2.2
2.9
27.16
60.94
u/ml
1.99
59
503
39
293
1.34
0.97
3.5
2.6
0.68
0.65
%
0.26
39
293
19
124
1.54
0.97
1.2
1.1
5337.35
149.86
iu/ml
—
6
34
9
51
1.77
0.94
1.1
1.0
—
—
—
0
0
63
508
1.25
0.94
2.2
2.9
162.83
174.06
ng/l
0.10
58
461
21
142
1.49
0.92
1.8
1.4
—
—
—
0
0
258
2351
1.13
0.92
4.7
3.6
0.00
0.00
estimate
1.34
86
831
6
28
2.15
0.91
2.8
1.9
—
—
—
0
0
6
28
2.15
0.91
2.8
1.9
—
—
—
0
0
26
185
1.41
0.90
1.5
1.6
—
—
—
0
0
6
29
2.07
0.89
3.0
1.9
—
—
—
0
0
12
71
1.70
0.89
1.1
1.3
—
—
—
0
0
14
87
1.62
0.87
1.1
1.1
—
—
—
0
0
8
43
1.87
0.87
2.5
1.6
—
—
—
0
0
6
33
1.82
0.79
1.0
1.0
—
—
—
0
0
10
59
1.70
0.76
1.7
1.5
0.96
1.00
g/l
—
10
59
9
53
1.70
0.75
1.2
1.5
—
—
—
0
0
73
616
1.20
0.75
2.4
2.3
69.27
71.64
ml/min/173m2
0.17
27
228
35
446
0.78
0.74
1.4
1.5
—
—
—
0
0
7
39
1.80
0.72
1.4
2.3
—
—
—
0
0
7
39
1.80
0.72
1.4
2.3
—
—
—
0
0
112
984
1.15
0.72
3.2
2.8
0.75
0.72
ug/l
0.12
72
602
73
620
1.19
0.71
4.0
3.4
1.23
1.23
mmol/l
0.15
61
521
22
296
0.74
0.69
1.9
1.7
—
—
—
0
0
360
3390
1.09
0.69
4.6
3.4
—
—
—
0
0
28
362
0.77
0.67
1.4
1.4
—
—
—
0
0
28
362
0.77
0.67
1.4
1.4
—
—
—
0
0
19
136
1.40
0.67
1.7
1.6
—
—
—
0
0
28
361
0.77
0.66
1.4
1.4
—
—
—
0
0
28
361
0.77
0.66
1.4
1.4
—
—
—
0
0
23
171
1.35
0.66
1.7
2.5
3.12
6.57
umol/l
1.78
17
123
31
243
1.28
0.63
2.7
2.9
22.74
686.13
u/ml
0.78
24
204
19
139
1.37
0.60
1.7
1.6
—
—
—
0
0
19
139
1.37
0.60
1.7
1.6
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
8
51
1.57
0.60
1.1
1.2
—
—
—
0
0
58
680
0.84
0.59
1.5
1.6
—
—
—
0
0
27
211
1.29
0.57
1.0
1.1
6.53
6.98
u/ml
0.04
16
126
12
82
1.47
0.54
2.0
1.5
—
—
—
0
0
9
60
1.50
0.54
1.2
1.6
—
—
—
0
0
9
62
1.46
0.53
1.3
1.3
1.00
1.37
promille
—
9
47
9
62
1.46
0.53
1.2
1.1
—
—
—
0
0
9
62
1.46
0.53
1.2
1.1
—
—
—
0
0
6
39
1.54
0.53
1.0
1.2
—
90.00
—
0
5
10
66
1.52
0.52
2.0
1.6
—
—
—
0
0
9
63
1.43
0.52
1.2
1.1
—
—
—
0
0
9
63
1.43
0.52
1.2
1.1
—
—
—
0
0
9
63
1.43
0.52
1.2
1.1
—
—
—
0
0
23
179
1.29
0.51
2.4
4.4
52.65
56.50
%
0.54
23
179
83
932
0.88
0.50
1.8
1.6
—
—
—
0
0
10
67
1.50
0.49
2.1
1.5
—
—
—
0
0
10
67
1.50
0.49
2.1
1.5
—
—
—
0
0
10
67
1.50
0.49
2.1
1.5
—
—
—
0
0
7
47
1.49
0.47
2.3
2.8
581.86
1005.91
u/ml
—
7
47
13
95
1.37
0.44
1.1
1.0
—
—
—
0
0
23
184
1.26
0.43
1.3
1.3
—
—
—
0
0
11
78
1.41
0.43
4.9
2.2
107.73
105.62
mmol/l
0.94
11
78
11
78
1.41
0.43
4.9
2.2
4.09
3.97
mmol/l
0.39
11
78
5
32
1.56
0.42
2.4
3.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
8
59
1.36
0.41
1.1
1.2
—
—
—
0
0
10
71
1.41
0.39
4.7
3.6
—
—
—
0
0
12
89
1.35
0.38
1.3
1.6
—
—
—
0
0
13
98
1.33
0.37
2.4
2.1
—
—
—
0
0
5
37
1.35
0.37
1.0
1.2
—
—
—
0
0
18
145
1.25
0.34
1.1
1.1
—
—
—
0
0
6
46
1.31
0.33
1.2
1.1
—
—
—
0
0
7
53
1.32
0.31
1.7
1.5
1.58
1.56
g/l
—
7
53
13
102
1.28
0.30
1.0
1.1
—
—
—
0
0
9
75
1.20
0.25
1.1
1.1
167.11
208.56
mg/l
—
9
64
10
78
1.28
0.24
1.0
1.1
—
—
—
0
0
21
181
1.16
0.22
1.6
1.6
0.70
0.35
nmol/l
0.60
16
149
10
79
1.27
0.22
1.1
1.2
22.89
30.00
mg/l
—
10
58
40
362
1.11
0.22
1.6
1.4
—
—
—
0
0
13
107
1.22
0.21
1.0
1.1
—
—
—
0
0
5
42
1.19
0.21
1.2
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
5.7
—
—
—
0
0
5
43
1.16
0.21
1.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
19.41
—
0
8
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
6.4
—
—
—
0
0
140
1340
1.05
0.20
4.2
3.9
23.29
21.31
%
0.53
49
597
6
50
1.20
0.19
1.0
1.3
—
—
—
0
0
35
385
0.91
0.19
1.3
1.4
—
—
—
0
0
11
132
0.83
0.18
1.3
1.1
—
—
—
0
0
11
132
0.83
0.18
2.6
1.7
—
1666.67
—
0
6
23
204
1.13
0.18
1.0
1.1
0.77
1.83
u/ml
0.75
12
108
7
60
1.17
0.18
1.4
1.3
—
—
—
0
0
7
61
1.15
0.17
1.0
1.1
—
—
—
0
0
13
110
1.18
0.17
1.3
1.5
—
—
—
0
0
5
66
0.76
0.17
3.8
1.6
—
—
—
0
0
94
986
0.95
0.17
7.3
5.7
—
—
—
0
0
8
68
1.18
0.16
1.4
1.1
—
—
—
0
0
11
92
1.20
0.16
2.0
1.7
90.40
90.38
%
0.00
11
92
11
93
1.18
0.14
10.1
5.8
10.70
10.71
mg/l
0.00
11
83
40
376
1.07
0.11
3.2
1.8
—
—
—
0
0
31
330
0.94
0.09
1.7
1.6
—
—
—
0
0
6
54
1.11
0.09
1.8
1.5
2.77
3.27
mg/l
—
6
49
5
62
0.81
0.08
1.2
1.3
63.60
78.19
umol/l
—
5
62
5
63
0.79
0.08
1.6
1.6
—
—
—
0
0
10
88
1.14
0.08
2.5
1.6
—
—
—
0
0
7
65
1.08
0.08
1.0
1.3
—
—
—
0
0
11
99
1.11
0.06
2.4
1.6
—
—
—
0
0
25
238
1.05
0.05
1.1
1.2
3.10
3.79
u/ml
0.09
14
136
21
201
1.05
0.03
1.2
1.2
—
—
—
0
0
22
211
1.04
0.03
1.0
1.1
2.52
1.87
u/ml
0.12
13
120
11
103
1.07
0.02
1.2
1.5
—
—
—
0
0
11
103
1.07
0.02
1.2
1.5
—
—
—
0
0
25
254
0.98
0.00
1.3
1.5
—
—
—
0
0
9
96
0.94
-0.00
1.1
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
5.0
—
—
—
0
0
5
55
0.91
-0.00
1.0
1.4
189.40
179.46
pmol/l
—
5
55
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
51
0.98
-0.00
1.2
7.4
—
68.50
—
0
14
0
6
0.00
-0.00
0.0
4.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_LACTONAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_LACTONAS | 1.268 [1.11, 1.45] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.206 |
During the follow-up period (1.1.1998 — 31.12.2019), 473 out of 3734 females with E4_LACTONAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_LACTONAS | 1.319 [1.13, 1.53] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 261 out of 2534 males with E4_LACTONAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_LACTONAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.096% | 0.259% |
| 5 | 0.704% | 1.519% |
| 10 | 1.844% | 3.612% |
| 15 | 3.403% | 6.835% |
| 20 | 6.048% | 11.223% |
Relationships between endpoints
↥Index endpoint: E4_LACTONAS – Lactose intolerance, other/unspecified
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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