No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1777 |
4. Check minimum number of eventsNone |
1777 |
5. Include endpointsNone |
1777 |
6. Filter based on genotype QC (FinnGen only) |
1777 |
Control definitions (FinnGen only)
- Control exclude
- G6_NERPLEX
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G57
- Name in latin
- Morbositas nervi ischiadici
Similar endpoints
↥List of similar endpoints to
Lesion of sciatic nerve
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 19701 | 9844 | 9570 |
| Only index persons | 13546 | 7540 | 6006 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.28 | 0.28 | 0.27 |
| Only index persons | 0.26 | 0.28 | 0.23 |
| Median age at first event (years) | |||
| Whole population | 45.13 | 45.57 | 44.49 |
| Only index persons | 41.89 | 43.07 | 40.41 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1777 | 828 | 949 |
| Unadjusted period prevalence (%) | 0.35 | 0.28 | 0.42 |
| Median age at first event (years) | 41.10 | 39.95 | 42.11 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1631
- Matched controls
- 16309
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
35399
ICD-8 Finland
Sciatica
+∞
323.0
1309
*
G57.0
ICD-10 Finland
Lesion of sciatic nerve
1132.8
297.4
282
*
72510
ICD-8 Finland
Displacement of intervertebral disk, Lumbalis cum prolapsu disci
19.2
219.1
347
226
G56.0
ICD-10 Finland
Carpal tunnel syndrome
23.9
140.3
204
97
72880
ICD-8 Finland
Vertebrogenic pain syndrome, Radicula syndrome of lower limbs
15.9
113.2
190
134
ACC51
NOMESCO Finland
Release of median nerve
177.3
96.3
100
6
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
4.4
78.8
326
885
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
54.7
78.2
93
18
N03AX16
ATC
pregabalin; oral
3.1
71.6
485
1951
N02AX02
ATC
tramadol; systemic, rectal
2.5
66.6
826
4734
72870
ICD-8 Finland
Vertebrogenic pain syndrome, Lumbalgia
13.2
64.1
115
93
7227C
ICD-9 Finland
Intervertebral disk disorders, Intervertebral disk disorder with myelopathy[SYNDROMA ISCHIADICUM]
7.0
58.7
153
239
M48.0
ICD-10 Finland
Spinal stenosis
3.3
56.4
329
1163
3550A
ICD-9 Finland
Mononeuritis of lower limb, Lesion of sciatic nerve
+∞
55.5
53
*
N03AX12
ATC
gabapentin; oral
3.2
52.6
314
1123
M54.4
ICD-10 Finland
Lumbago with sciatica
2.9
41.0
284
1109
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.6
39.8
326
1409
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
4.1
36.5
153
406
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
4.1
35.4
146
382
9211
FHL
Exploration or removal of diskusprolapse
6.6
33.7
89
141
XA402
NOMESCO Finland
ENMG
8.8
30.8
67
79
G57.3
ICD-10 Finland
Lesion of lateral popliteal nerve
22.6
30.5
44
20
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.2
30.3
384
2035
G56.2
ICD-10 Finland
Lesion of ulnar nerve
32.4
29.1
38
12
N06AA09
ATC
amitriptyline; systemic
2.7
28.7
208
824
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.8
27.6
671
4525
2402
FHL
External neurolysis of the nerve and possible alteration of the pathway (nerve pressure)
21.5
27.4
40
19
71312
ICD-8 Finland
Osteo-arthritis and allied conditions, Spondylarthritis lumbalis sive lumbosacralis
12.6
27.4
49
40
M17.1
ICD-10 Finland
Other primary gonarthrosis
2.0
26.4
396
2235
A02BC03
ATC
lansoprazole; oral
1.9
26.0
521
3274
N02AC04
ATC
dextropropoxyphene; oral
3.5
25.9
129
395
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.9
25.2
162
592
M54.5
ICD-10 Finland
Low back pain
1.9
25.2
466
2839
9212
FHL
Other posterior root decompression surgery (eg laminectomy, Gill)
11.0
25.1
48
45
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
28.0
24.5
33
12
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
24.4
517
3292
R07.4
ICD-10 Finland
Chest pain, unspecified
1.8
22.9
479
3025
72899
ICD-8 Finland
Vertebrogenic pain syndrome, Other and unspecified
14.4
22.6
38
27
7228C
ICD-9 Finland
Intervertebral disk disorders, Postlaminectomy syndrome[SYNDROMA LUMBOSACRALE POSTLAMINECTOMIAM]
18.7
21.8
33
18
72898
ICD-8 Finland
Vertebrogenic pain syndrome, Alia definita
14.7
21.7
36
25
N06AX21
ATC
duloxetine; oral
2.7
21.5
157
622
M01AE03
ATC
ketoprofen; systemic, rectal
1.7
21.0
630
4420
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.7
21.0
512
3381
M79.6
ICD-10 Finland
Pain in limb
1.7
20.9
520
3449
M01AC06
ATC
meloxicam; systemic, rectal
1.7
20.7
541
3638
M01AB05
ATC
diclofenac; systemic, rectal
1.6
20.1
932
7333
M54.3
ICD-10 Finland
Sciatica
3.1
20.1
113
378
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
4.4
20.0
74
175
M70.6
ICD-10 Finland
Trochanteric bursitis
2.3
20.0
207
984
M03BX02
ATC
tizanidine; oral
1.6
19.5
775
5837
N02AA05
ATC
oxycodone; systemic
2.0
19.3
294
1648
M19.0
ICD-10 Finland
Primary arthrosis of other joints
2.5
19.2
155
649
72519
ICD-8 Finland
Displacement of intervertebral disk, Lumbalis et lumbosacralis NUD
22.8
19.1
27
12
M03BC01
ATC
orphenadrine (citrate); systemic
2.0
18.9
284
1582
M79.0
ICD-10 Finland
Rheumatism, unspecified
4.3
18.2
68
163
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
3.1
18.1
104
354
A02BC05
ATC
esomeprazole; systemic
1.6
18.0
607
4350
C01DA14
ATC
isosorbide mononitrate; oral
1.8
17.9
400
2547
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
3.1
17.9
102
345
M54.1
ICD-10 Finland
Radiculopathy
3.9
17.9
75
200
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.9
17.8
316
1865
N02AJ06
ATC
codeine and paracetamol; systemic
1.7
17.6
476
3207
R03AC02
ATC
salbutamol; inhalant
1.6
17.3
739
5604
A02BC02
ATC
pantoprazole; systemic
1.6
17.3
983
7998
35708
ICD-8 Finland
Other diseases of peripheral nerves except autonomic, Alterius nervi
+∞
16.7
16
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.7
16.6
457
3083
71700
ICD-8 Finland
NA
13.5
16.5
28
21
G54.0
ICD-10 Finland
Brachial plexus disorders
16.9
16.1
25
15
G51.0
ICD-10 Finland
Bell palsy
24.7
16.0
22
9
A06AD11
ATC
lactulose; oral
1.8
15.9
310
1882
M47.9
ICD-10 Finland
Spondylosis, unspecified
3.7
15.9
70
196
L03
ICPC
Low back symptom/complaint
1.8
15.6
316
1936
3540A
ICD-9 Finland
Mononeuritis of upper limb and mononeuritis multiplex, Carpal tunnel syndrome
+∞
15.6
15
*
M25.5
ICD-10 Finland
Pain in joint
1.7
15.6
357
2277
G57.8
ICD-10 Finland
Other mononeuropathies of lower limb
161.4
15.5
16
*
H02AB06
ATC
prednisolone; systemic
1.5
15.5
722
5544
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.2
15.3
160
765
SPAT1153
SPAT
Removal of sutures
1.6
15.2
496
3487
N03AF01
ATC
carbamazepine; oral, rectal
2.8
15.1
97
357
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
2.6
15.0
108
425
M01AH05
ATC
etoricoxib; oral
1.5
14.9
726
5610
ABD30
NOMESCO Finland
Implantation of spinal stimulation device
16.6
14.8
23
14
M01AX17
ATC
nimesulide; oral
1.7
14.8
404
2708
M01AH01
ATC
celecoxib; oral (coxibs)
1.8
14.8
283
1705
ABC26
NOMESCO Finland
Open discectomy of lumbar spine
5.5
14.7
43
80
79199
ICD-8 Finland
Headache
5.1
14.6
46
93
M01AH02
ATC
rofecoxib; oral
1.9
14.3
237
1358
M96.1
ICD-10 Finland
Postlaminectomy syndrome, not elsewhere classified
10.5
14.2
27
26
R51.80
ICD-10 Finland
Headache
2.1
14.2
172
874
7240B
ICD-9 Finland
Other and unspecified disorders of back, Spinal stenosis, other than cervical[STENOSIS CANALIS SPINALIS LUMBOSACRALIS]
7.1
14.1
34
49
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
3.4
14.0
68
207
L86
ICPC
Back syndrome with radiating pain
2.8
13.9
89
326
M02AA07
ATC
piroxicam; topical
1.5
13.8
581
4318
R06.0
ICD-10 Finland
Dyspnoea
1.6
13.8
414
2834
G57.6
ICD-10 Finland
Lesion of plantar nerve
8.7
13.7
29
34
M53.1
ICD-10 Finland
Cervicobrachial syndrome
2.3
13.7
127
574
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.3
13.6
134
622
UJF32
NOMESCO Finland
Coloscopy
1.6
13.4
416
2872
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
1.9
13.3
193
1053
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.6
13.3
482
3457
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
6.9
13.2
32
47
N02BE01
ATC
paracetamol; systemic, rectal
1.6
13.2
1286
11452
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
3.8
13.2
55
148
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
13.1
453
3209
G57.2
ICD-10 Finland
Lesion of femoral nerve
50.4
12.8
15
*
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
2.8
12.8
80
290
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.6
12.8
464
3318
R42
ICD-10 Finland
Dizziness and giddiness
1.6
12.8
368
2486
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.6
12.7
387
2652
A02BC01
ATC
omeprazole; systemic
1.6
12.5
453
3236
N05BA01
ATC
diazepam; systemic, rectal
1.8
12.5
219
1279
ACC53
NOMESCO Finland
Release of ulnar nerve
130.9
12.4
13
*
M54.6
ICD-10 Finland
Pain in thoracic spine
2.7
12.3
84
320
M16.1
ICD-10 Finland
Other primary coxarthrosis
1.8
12.3
207
1191
G50.0
ICD-10 Finland
Trigeminal neuralgia
14.4
12.3
20
14
M03BC51
ATC
orphenadrine, combinations; systemic
1.6
12.3
347
2328
7221A
ICD-9 Finland
Intervertebral disk disorders, Displacement of thoracic or lumbar intervertebral disk without myelopathy
6.8
12.2
30
45
G44.2
ICD-10 Finland
Tension-type headache
2.0
12.2
165
875
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.1
12.1
148
753
M01AE01
ATC
ibuprofen; systemic, rectal
1.5
12.1
1209
10675
M01AB55
ATC
diclofenac, combinations; oral
2.1
12.1
135
663
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.0
12.0
156
817
M54.2
ICD-10 Finland
Cervicalgia
2.5
12.0
97
410
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.6
11.9
366
2509
M47.82
ICD-10 Finland
Other spondylosis, cervical region
3.0
11.7
67
228
B01AC07
ATC
dipyridamole; systemic
2.1
11.7
139
699
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
11.7
300
1957
M01AE02
ATC
naproxen; oral, rectal
1.4
11.7
736
5901
J01FF01
ATC
clindamycin; systemic
1.6
11.7
377
2615
G56.4
ICD-10 Finland
Causalgia
65.4
11.6
13
*
J01DA01
ATC
[U] cefalexin; systemic
1.4
11.5
910
7618
C03CA01
ATC
furosemide; systemic
1.5
11.5
613
4749
3557X
ICD-9 Finland
Mononeuritis of lower limb, Other mononeuritis of lower limb
+∞
11.5
11
*
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
1.8
11.4
228
1385
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.6
11.4
86
348
J01DB01
ATC
cefalexin; oral
1.5
11.4
1148
10069
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.2
11.3
119
570
J01FA06
ATC
roxithromycin; oral
1.5
11.3
571
4372
SPAT1097
SPAT
Recording of ECG
1.7
11.2
247
1545
M01AB08
ATC
etodolac; oral
2.2
11.2
110
510
A01
ICPC
Pain general/multiple sites
2.2
11.2
120
580
N06AX11
ATC
mirtazapine; oral
1.5
11.2
427
3076
72599
ICD-8 Finland
Displacement of intervertebral disk, Unspecified site
25.2
11.1
15
6
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.9
11.1
162
884
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.7
11.1
231
1419
A03FA02
ATC
cisapride; oral, rectal
2.0
10.9
143
749
SPAT1301
SPAT
No procedures
1.5
10.8
494
3697
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
2.2
10.7
114
547
L15
ICPC
Knee symptom/complaint
1.6
10.7
283
1858
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
5.4
10.7
31
58
G55.2*M47.9
ICD-10 Finland
Nerve root and plexus compressions in spondylosis
28.2
10.7
14
5
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.9
10.6
62
216
N05CF01
ATC
zopiclone; oral
1.5
10.6
535
4082
N06AX16
ATC
venlafaxine; oral
2.0
10.5
141
748
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.5
10.5
457
3379
R52.2
ICD-10 Finland
Other chronic pain
3.1
10.5
55
179
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
2.0
10.3
131
682
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.0
10.2
130
675
J01AA02
ATC
doxycycline; systemic
1.4
10.2
1153
10210
J01MA02
ATC
ciprofloxacin; systemic
1.4
10.2
607
4777
SPAT1229
SPAT
Assessment of need for aid
1.9
10.1
155
864
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
2.5
10.0
78
323
A29
ICPC
General symptom/complaint other
1.8
9.9
178
1041
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
3.9
9.9
39
101
I20.09
ICD-10 Finland
Unstable angina
2.1
9.9
117
589
L13
ICPC
Hip symptom/complaint
1.7
9.9
240
1541
N05BB01
ATC
hydroxyzine; systemic
2.2
9.8
98
456
ACC19
NOMESCO Finland
Transcision of peripheral nerve: other or unspecified
20.1
9.8
14
7
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.6
9.7
267
1771
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
9.7
612
4858
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
9.7
478
3620
L01
ICPC
Neck symptom/complaint
1.8
9.6
172
1006
M47.80
ICD-10 Finland
Other spondylosis, multiple sites in spine
3.3
9.6
47
146
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
1.5
9.6
397
2897
S18
ICPC
Laceration/cut
1.4
9.5
607
4820
R05DA20
ATC
opium alkaloids and derivatives - combinations
1.5
9.5
362
2594
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
2.3
9.4
86
388
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
1.8
9.4
156
893
A03CA02
ATC
clidinium and psycholeptics; oral
2.0
9.4
115
587
SPAT1263
SPAT
Sampling
1.4
9.3
591
4687
M79.7
ICD-10 Finland
Fibromyalgia
3.6
9.2
40
113
J01EA01
ATC
trimethoprim; systemic
1.5
9.2
386
2820
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
2.6
9.1
65
255
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.5
9.1
296
2043
213
Kela drug reimbursment
Fat metabolism disorder associated with chronic coronary artery disease
1.7
9.1
174
1044
AEA00
NOMESCO Finland
Replacement of impulse generator of stimulation device in the nervous system
15.7
9.0
14
9
SPAT1254
SPAT
Administration of medicine
1.6
9.0
239
1568
S46.0
ICD-10 Finland
Injury of muscle(s) and tendon(s) of the rotator cuff of shoulder
1.9
9.0
127
687
P01AB01
ATC
metronidazole; oral, rectal
1.4
9.0
505
3907
M01AB51
ATC
indometacin, combinations; oral, rectal
2.9
8.9
52
182
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.6
8.9
235
1541
SPAT1203
SPAT
Injection therapy, other than intramuscular or subcutaneous
2.4
8.9
73
310
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.8
8.8
165
982
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.8
8.8
153
890
7244A
ICD-9 Finland
Other and unspecified disorders of back, Thoracic or lumbosacral neuritis or radiculitis, unspecified
9.5
8.8
17
18
78559
ICD-8 Finland
Symptoms referable to abdomen and lower gastro-intestinal tract, Colica abdominalis NUD
2.8
8.7
55
202
NBA30
NOMESCO Finland
Exploration of joint of shoulder or upper arm, arthroscopic
3.1
8.5
44
143
72800
ICD-8 Finland
Vertebrogenic pain syndrome, Cervicalgia
9.0
8.5
17
19
1220
FHL
Arthroscopy
2.4
8.5
68
287
SPAT1260
SPAT
Consultation of another employee
1.6
8.5
258
1753
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
8.4
217
1412
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.5
8.4
338
2444
G55.1*M51.9
ICD-10 Finland
Nerve root and plexus compressions in intervertebral disc disorders (M50-M51+)
90.5
8.4
9
*
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
8.4
409
3074
ABD32
NOMESCO Finland
Implantation of temporary spinal stimulation device
12.8
8.4
14
11
R52.1
ICD-10 Finland
Chronic intractable pain
7.9
8.4
18
23
G54.4
ICD-10 Finland
Lumbosacral root disorders, not elsewhere classified
+∞
8.3
8
*
R30.0
ICD-10 Finland
Dysuria
2.7
8.3
55
210
SPAT1216
SPAT
Assessment of functional ability
1.5
8.3
270
1862
H02AB04
ATC
methylprednisolone; systemic
1.6
8.3
206
1327
SPAT1310
SPAT
Counselling related to known health issue
1.4
8.2
430
3275
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
2.0
8.2
98
495
J01CA08
ATC
pivmecillinam; oral
1.4
8.2
504
3951
A02BA02
ATC
ranitidine; systemic
1.5
8.2
327
2361
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
3.2
8.1
40
126
M51.9
ICD-10 Finland
Intervertebral disc disorder, unspecified
4.4
8.1
28
65
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.7
8.1
162
981
SPAT1104
SPAT
Monitoring of emergency patient
2.0
8.1
106
557
L11
ICPC
Wrist symptom/complaint
2.1
8.1
91
450
R69
ICD-10 Finland
Unknown and unspecified causes of morbidity
3.3
8.1
39
121
G57.9
ICD-10 Finland
Mononeuropathy of lower limb, unspecified
22.1
8.0
11
5
Y0209
ICD-8 Finland
Examination of the nervous system and sensory organs, Nervous system
5.9
8.0
21
36
L08
ICPC
Shoulder symptom/complaint
1.6
8.0
247
1682
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.4
7.9
466
3622
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.0
7.9
92
462
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
3.5
7.9
35
102
H43.8
ICD-10 Finland
Other disorders of vitreous body
1.8
7.9
122
683
C07AB02
ATC
metoprolol; systemic
1.4
7.9
391
2943
G50.1
ICD-10 Finland
Atypical facial pain
7.0
7.8
18
26
Y0499
ICD-8 Finland
Investigation of respiratory system
3.6
7.8
33
93
78551
ICD-8 Finland
Symptoms referable to abdomen and lower gastro-intestinal tract, Symptomata abdominalis acuta NUD
2.8
7.7
47
171
M01AE51
ATC
ibuprofen, combinations; systemic
3.2
7.7
38
120
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
2.0
7.6
88
442
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.6
7.6
217
1450
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.6
7.6
230
1561
NDM40
NOMESCO Finland
Discission of sheath of tendon of wrist or hand
3.8
7.6
30
80
71798
ICD-8 Finland
Other nonarticular rheumatism, Other muscular rheumatism, fibrositis and myalgia
5.2
7.6
22
43
7245A
ICD-9 Finland
Other and unspecified disorders of back, Backache, unspecified
4.3
7.5
26
61
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
1.7
7.5
143
853
B01AB05
ATC
enoxaparin; parenteral
1.4
7.5
448
3482
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.7
7.4
152
932
M53.0
ICD-10 Finland
Cervicocranial syndrome
2.0
7.4
92
476
R03AC03
ATC
terbutaline; inhalant
1.6
7.4
177
1131
M02AA10
ATC
ketoprofen; topical
1.5
7.3
224
1522
M03BB52
ATC
chlormezanone, combinations excl. psycholeptics; oral, rectal
3.0
7.3
40
137
119
Kela drug reimbursment
Trigeminal neuralgia or glossofaryngeusneuralgia
+∞
7.3
7
*
WX704
NOMESCO Finland
Intubation
2.0
7.3
87
441
C08CA07
ATC
nisoldipine; oral
3.2
7.3
36
115
SPAT1100
SPAT
Long-term monitoring of blood pressure
1.8
7.2
127
740
G57.1
ICD-10 Finland
Meralgia paraesthetica
6.3
7.2
18
29
J46
ICD-10 Finland
Status asthmaticus
2.8
7.2
44
161
G47.3
ICD-10 Finland
Sleep apnoea
1.5
7.2
234
1614
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.5
7.2
234
1615
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
1.7
7.1
143
869
9481
FHL
Detachment or severance of a muscle or tendon
6.1
7.1
18
30
7242A
ICD-9 Finland
Other and unspecified disorders of back, Lumbago
8.8
7.0
14
16
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.6
7.0
192
1266
N03AE01
ATC
clonazepam; systemic
2.1
7.0
79
394
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
1.9
7.0
101
552
M09AX01
ATC
hyaluronic acid; parenteral
1.9
6.9
93
496
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
2.2
6.9
69
327
M15.0
ICD-10 Finland
Primary generalized (osteo)arthrosis
2.5
6.9
50
203
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.6
6.9
189
1247
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
3.5
6.9
30
87
K30
ICD-10 Finland
Functional dyspepsia
1.7
6.9
129
766
UKC02
NOMESCO Finland
Cystoscopy
1.5
6.9
281
2032
N93
ICPC
Carpal tunnel syndrome
13.8
6.9
11
8
AA1AD
NOMESCO Finland
CT of head and brain
1.4
6.9
370
2820
M51.8
ICD-10 Finland
Other specified intervertebral disc disorders
4.8
6.8
21
44
79399
ICD-8 Finland
Observation, without need for further medical care, Unspecified
4.4
6.8
23
53
M89.0
ICD-10 Finland
Algoneurodystrophy
6.7
6.8
16
24
R35
ICD-10 Finland
Polyuria
1.9
6.8
98
537
K07.60
ICD-10 Finland
Snapping jaw
2.7
6.8
42
156
L12
ICPC
Hand/finger symptom/complaint
1.6
6.7
162
1037
4111X
ICD-9 Finland
Other acute and subacute forms of ischaemic heart disease, Intermediate coronary syndrome[PITKITTYNYT ANGINA PECTORIS -KOHTAUS,MÄÄRITTELEMÄT]
3.2
6.7
33
105
A04
ICPC
Weakness/tiredness general
1.6
6.7
189
1259
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.2
6.7
63
291
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.5
6.7
210
1435
S83.2
ICD-10 Finland
Tear of meniscus, current
2.1
6.7
69
331
E9199
ICD-8 Finland
Over-exertion and strenuous movements
6.4
6.6
16
25
M79.1
ICD-10 Finland
Myalgia
1.7
6.6
143
886
M09AA72
ATC
quinine, combinations with psycholeptics; systemic
2.0
6.6
76
384
SPAT1249
SPAT
Treatment-related counselling outside office
1.3
6.6
516
4184
R55
ICD-10 Finland
Syncope and collapse
1.6
6.6
181
1199
R09
ICPC
Sinus symptom/complaint
2.1
6.5
69
336
310
Kela drug reimbursment
Orlistat, sibutramine and other major and expensive medicines used to treat obesity
4.4
6.5
22
51
JN3AD
NOMESCO Finland
Abdominal CT examination
1.8
6.5
103
581
4130X
ICD-9 Finland
Angina pectoris, Angina decubitus[ANGINA PECTORIS (""""EFFORT ANGINA""""),MÄÄRITTELEMÄT]
2.4
6.5
53
228
L02
ICPC
Back symptom/complaint
1.9
6.5
97
538
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.7
6.5
140
868
M43.1
ICD-10 Finland
Spondylolisthesis
2.4
6.4
50
211
SPAT1240
SPAT
Therapeutic discussion
1.9
6.4
87
465
M75.0
ICD-10 Finland
Adhesive capsulitis of shoulder
2.1
6.4
70
344
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
1.9
6.4
85
451
G56.1
ICD-10 Finland
Other lesions of median nerve
70.1
6.4
7
*
J01CA04
ATC
amoxicillin; systemic
1.3
6.4
1059
9533
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.5
6.4
221
1542
L28
ICPC
Limited function/disability (L)
1.5
6.4
264
1911
E66.01
ICD-10 Finland
Obesity due to excess calories
2.1
6.4
68
333
M01AX01
ATC
nabumetone; oral
2.1
6.4
67
324
I20.99
ICD-10 Finland
Angina pectoris, unspecified
1.7
6.3
129
789
WZA00
NOMESCO Finland
Short statement of of health and health related matters
2.2
6.3
60
279
M01AX05
ATC
glucosamine; oral
1.4
6.3
322
2426
71310
ICD-8 Finland
Osteo-arthritis and allied conditions, Spondylarthritis cervicalis
4.6
6.3
20
44
A10AD05
ATC
insulin aspart; parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
2.6
6.3
42
164
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.6
6.3
149
949
E883A
ICD-9 Finland
Fall into hole or other opening in surface
2.0
6.3
73
369
35701
ICD-8 Finland
Other diseases of peripheral nerves except autonomic, Nervi mediani
+∞
6.3
6
*
M01AB01
ATC
indometacin; systemic, rectal
1.6
6.2
141
886
N04BC05
ATC
pramipexole; oral
1.8
6.2
108
630
NBG10
NOMESCO Finland
Acromioplastia
2.6
6.2
44
175
R52.9
ICD-10 Finland
Pain, unspecified
1.8
6.2
102
583
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
1.8
6.2
104
601
E66.8
ICD-10 Finland
Other obesity
2.5
6.2
47
194
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
2.5
6.2
47
195
NDG60
NOMESCO Finland
Arthroplasty of first CMC joint
4.5
6.2
20
45
M45
ICD-10 Finland
Ankylosing spondylitis
3.3
6.2
28
85
A11
ICPC
Chest pain NOS
1.8
6.1
110
646
A02BA04
ATC
nizatidine; systemic
1.7
6.1
130
803
WX725
NOMESCO Finland
Noninvasive ventilation
2.2
6.1
58
269
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.7
6.1
117
704
27799
ICD-8 Finland
Obesity not specified as of endocrine origin
4.7
6.1
19
41
M70.7
ICD-10 Finland
Other bursitis of hip
2.6
6.1
41
161
-
ICD-10 Finland
NA
2.6
6.1
40
154
41399
ICD-8 Finland
Angina pectoris, Without mention of hypertensive disease
3.1
6.1
30
97
A07AA02
ATC
nystatin; oral
1.8
6.0
97
552
A01AB09
ATC
miconazole; local oral
1.6
6.0
137
863
81
HP
Angiography of the heart and coronary arteries
1.6
6.0
137
863
Mortality – FinRegistry
↥Association
Association between endpoint G6_SCIALE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_SCIALE | 1.172 [0.97, 1.42] | 0.101 |
| Birth year | 0.997 [0.99, 1.01] | 0.488 |
During the follow-up period (1.1.1998 — 31.12.2019), 163 out of 1132 females with G6_SCIALE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_SCIALE | 1.186 [0.97, 1.45] | 0.102 |
| Birth year | 0.991 [0.98, 1.0] | 0.046 |
During the follow-up period (1.1.1998 — 31.12.2019), 132 out of 704 males with G6_SCIALE died.
Mortality risk
Mortality risk for people of age
years, who have G6_SCIALE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.119% | 0.265% |
| 5 | 0.738% | 1.466% |
| 10 | 1.822% | 3.853% |
| 15 | 3.507% | 7.224% |
| 20 | 6.276% | 12.375% |
Relationships between endpoints
↥Index endpoint: G6_SCIALE – Lesion of sciatic nerve
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data