obsolete_refractive error: ['Deviations from the average or standard indices of refraction of the eye through its dioptric or refractive apparatus.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1172 |
4. Check minimum number of eventsNone |
1172 |
5. Include endpointsNone |
1172 |
6. Filter based on genotype QC (FinnGen only) |
1172 |
Control definitions (FinnGen only)
- Control exclude
- H7_OCUMUSCLE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H52
- Name in latin
- Anisometropia sive aniseiconia
Similar endpoints
↥List of similar endpoints to
Anisometropia and aniseikonia
based on the number of shared cases.
Similar with more cases:
- Disorders of refraction and accommodation
- Disorders of ocular muscles, binocular movement, accommodation and refraction
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13920 | 7671 | 6203 |
| Only index persons | 10627 | 5992 | 4635 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.20 | 0.22 | 0.17 |
| Only index persons | 0.20 | 0.22 | 0.18 |
| Median age at first event (years) | |||
| Whole population | 13.02 | 16.52 | 8.40 |
| Only index persons | 23.43 | 30.46 | 14.34 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1172 | 759 | 413 |
| Unadjusted period prevalence (%) | 0.23 | 0.26 | 0.18 |
| Median age at first event (years) | 51.04 | 48.55 | 55.61 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1030
- Matched controls
- 10300
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H52.3
ICD-10 Finland
Anisometropia and aniseikonia
6597.7
323.0
876
8
37002
ICD-8 Finland
Refractive errors, Myopia
+∞
151.9
142
*
H52.1
ICD-10 Finland
Myopia
53.6
149.2
178
40
Z96.1
ICD-10 Finland
Presence of intraocular lens
6.7
102.9
297
585
H52.2
ICD-10 Finland
Astigmatism
124.2
94.8
101
9
H53.0
ICD-10 Finland
Amblyopia ex anopsia
66.4
88.7
102
17
H52.0
ICD-10 Finland
Hypermetropia
57.3
79.8
94
18
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.8
78.4
439
1670
H25.0
ICD-10 Finland
Senile incipient cataract
6.1
48.0
139
256
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
2.8
47.5
438
2173
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.2
47.0
198
549
H50.31
ICD-10 Finland
Intermittent exotropia
412.9
40.4
40
*
H25.1
ICD-10 Finland
Senile nuclear cataract
2.8
37.9
306
1361
H50.0
ICD-10 Finland
Convergent concomitant strabismus
348.1
34.1
34
*
CGD10
NOMESCO Finland
Laser keratoplasty for error of refraction
120.6
32.9
35
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.3
32.7
461
2711
H50.1
ICD-10 Finland
Divergent concomitant strabismus
+∞
31.4
30
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.9
31.3
137
386
H26.4
ICD-10 Finland
After-cataract
3.7
30.5
146
443
37301
ICD-8 Finland
Strabismus, Concomitans divergens
+∞
28.2
27
*
H26.02
ICD-10 Finland
Presenil cataract
7.8
27.0
63
85
H50.30
ICD-10 Finland
Intermittent esotropy
266.9
25.8
26
*
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
+∞
25.1
24
*
H25.8
ICD-10 Finland
Other senile cataract
3.1
23.7
143
513
CGD20
NOMESCO Finland
Laser-assisted in situ keratomileusis
127.9
23.7
25
*
H52.4
ICD-10 Finland
Presbyopia
11.5
23.1
43
39
H50.2
ICD-10 Finland
Vertical strabismus
+∞
23.0
22
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.8
18.6
130
508
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
19.8
18.2
27
14
H33.0
ICD-10 Finland
Retinal detachment with retinal break
5.9
17.7
50
89
XCK00
NOMESCO Finland
Perimetry
3.3
17.7
93
302
WX140
NOMESCO Finland
Parabulbar anesthesy
4.3
17.2
64
155
S01BA07
ATC
fluorometholone; ophthalmic (corticosteroids, plain)
7.0
17.1
42
62
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.2
16.8
191
966
H53.2
ICD-10 Finland
Diplopia
6.2
16.5
44
73
CG2T4
NOMESCO Finland
Topography assessment of cornea
15.6
16.2
26
17
ZXE00
NOMESCO Finland
One hour or less
1.7
14.8
416
2902
H50.52
ICD-10 Finland
Exophoria
27.6
14.3
19
7
3673A
ICD-9 Finland
Disorders of refraction and accommodation, Anisometropia and aniseikonia
+∞
13.6
13
*
37600
ICD-8 Finland
Detachment of retina, Primaria
141.7
13.5
14
*
37300
ICD-8 Finland
Strabismus, Concomitans convergens
+∞
12.5
12
*
37303
ICD-8 Finland
Strabismus, Heterophoria (exophoria, esophroria, hypophoria)
+∞
11.5
11
*
CJF10
NOMESCO Finland
Secondary implantation of artificial lens in posterior chamber
121.3
11.4
12
*
H50.51
ICD-10 Finland
Esophoria
121.3
11.4
12
*
H44.2
ICD-10 Finland
Degenerative myopia
35.4
11.3
14
*
XCK10
NOMESCO Finland
Photography of fundus of eye
2.3
10.9
104
482
CEC00
NOMESCO Finland
Recession of extraocular muscle
+∞
10.4
10
*
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
+∞
10.4
10
*
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
3.8
10.3
42
113
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.1
10.2
116
582
H53.1
ICD-10 Finland
Subjective visual disturbances
2.6
10.1
72
287
ZXD20
NOMESCO Finland
Day surgery
2.0
9.9
132
708
Z3229
NOMESCO Finland
Other healthcare associate professional
2.2
9.3
96
463
ZXA00
NOMESCO Finland
Right side
1.6
9.1
247
1664
H26.2
ICD-10 Finland
Complicated cataract
5.9
8.6
23
40
S01ED51
ATC
timolol, combinations; ophthalmic
2.4
8.6
72
314
H04.10
ICD-10 Finland
Dry eye syndrome
2.1
8.6
96
478
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.6
8.5
62
251
3671A
ICD-9 Finland
Disorders of refraction and accommodation, Myopia
+∞
8.3
8
*
H49.1
ICD-10 Finland
Fourth [trochlear] nerve palsy
+∞
8.3
8
*
37602
ICD-8 Finland
Detachment of retina, Foramen, ruptura retinae
+∞
8.3
8
*
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
25.2
7.6
10
*
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
3.2
7.5
37
118
WX110
NOMESCO Finland
Local anesthesy
1.5
7.5
667
5750
3680A
ICD-9 Finland
Visual disturbances, Amblyopia ex anopsia
80.6
7.4
8
*
CEW99
NOMESCO Finland
Other operation on extraocular muscle
+∞
7.3
7
*
3503
FHL
Single muscle retroposition
+∞
7.3
7
*
S01EE01
ATC
latanoprost; ophthalmic
2.4
7.3
58
248
N03AG01
ATC
valproic acid; systemic, rectal
2.4
7.3
60
261
H54.5
ICD-10 Finland
Severe visual impairment, monocular
15.9
7.2
11
7
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
3.8
7.1
28
75
114
Kela drug reimbursment
Glaucoma
2.1
7.0
76
377
Z3231
NOMESCO Finland
Registered nurse
1.5
6.7
261
1894
ZXA10
NOMESCO Finland
Bilateral
1.6
6.6
173
1141
H53.8
ICD-10 Finland
Other visual disturbances
5.2
6.6
19
37
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
7.5
6.4
14
19
H16.0
ICD-10 Finland
Corneal ulcer
2.5
6.4
48
199
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
+∞
6.3
6
*
37000
ICD-8 Finland
Refractive errors, Astigmatismus
+∞
6.3
6
*
CEC60
NOMESCO Finland
Transposition of extraocular muscle with adjustable suture
+∞
6.3
6
*
37003
ICD-8 Finland
Refractive errors, Anisometropia
+∞
6.3
6
*
H40.0
ICD-10 Finland
Glaucoma suspect
2.1
6.2
68
338
WX002
NOMESCO Finland
Sedation and analgesia
1.6
6.1
175
1182
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.0
6.1
77
404
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
2.5
6.0
43
174
Mortality – FinRegistry
↥Association
Association between endpoint H7_ANISOMETROPIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_ANISOMETROPIA | 0.844 [0.73, 0.97] | 0.021 |
| Birth year | 0.992 [0.98, 1.0] | 0.089 |
During the follow-up period (1.1.1998 — 31.12.2019), 417 out of 5603 females with H7_ANISOMETROPIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_ANISOMETROPIA | 1.023 [0.85, 1.22] | 0.807 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 288 out of 4430 males with H7_ANISOMETROPIA died.
Mortality risk
Mortality risk for people of age
years, who have H7_ANISOMETROPIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.097% | 0.203% |
| 5 | 0.511% | 1.122% |
| 10 | 1.205% | 2.815% |
| 15 | 2.278% | 5.208% |
| 20 | 3.952% | 8.999% |
Relationships between endpoints
↥Index endpoint: H7_ANISOMETROPIA – Anisometropia and aniseikonia
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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