obsolete_refractive error: ['Deviations from the average or standard indices of refraction of the eye through its dioptric or refractive apparatus.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1172 |
4. Check minimum number of eventsNone |
1172 |
5. Include endpointsNone |
1172 |
6. Filter based on genotype QC (FinnGen only) |
1172 |
Control definitions (FinnGen only)
- Control exclude
- H7_OCUMUSCLE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H52
- Name in latin
- Anisometropia sive aniseiconia
Similar endpoints
↥List of similar endpoints to
Anisometropia and aniseikonia
based on the number of shared cases.
Similar with more cases:
- Disorders of refraction and accommodation
- Disorders of ocular muscles, binocular movement, accommodation and refraction
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13920 | 7671 | 6203 |
| Only index persons | 10627 | 5992 | 4635 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.20 | 0.22 | 0.17 |
| Only index persons | 0.20 | 0.22 | 0.18 |
| Median age at first event (years) | |||
| Whole population | 13.02 | 16.52 | 8.40 |
| Only index persons | 23.43 | 30.46 | 14.34 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1172 | 759 | 413 |
| Unadjusted period prevalence (%) | 0.23 | 0.26 | 0.18 |
| Median age at first event (years) | 51.04 | 48.55 | 55.61 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1030
- Matched controls
- 10300
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H52.3
ICD-10 Finland
Anisometropia and aniseikonia
6597.7
323.0
876
8
37002
ICD-8 Finland
Refractive errors, Myopia
+∞
151.9
142
*
H52.1
ICD-10 Finland
Myopia
53.6
149.2
178
40
Z96.1
ICD-10 Finland
Presence of intraocular lens
6.7
102.9
297
585
H52.2
ICD-10 Finland
Astigmatism
124.2
94.8
101
9
H53.0
ICD-10 Finland
Amblyopia ex anopsia
66.4
88.7
102
17
H52.0
ICD-10 Finland
Hypermetropia
57.3
79.8
94
18
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.8
78.4
439
1670
H25.0
ICD-10 Finland
Senile incipient cataract
6.1
48.0
139
256
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
2.8
47.5
438
2173
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.2
47.0
198
549
H50.31
ICD-10 Finland
Intermittent exotropia
412.9
40.4
40
*
H25.1
ICD-10 Finland
Senile nuclear cataract
2.8
37.9
306
1361
H50.0
ICD-10 Finland
Convergent concomitant strabismus
348.1
34.1
34
*
CGD10
NOMESCO Finland
Laser keratoplasty for error of refraction
120.6
32.9
35
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.3
32.7
461
2711
H50.1
ICD-10 Finland
Divergent concomitant strabismus
+∞
31.4
30
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.9
31.3
137
386
H26.4
ICD-10 Finland
After-cataract
3.7
30.5
146
443
37301
ICD-8 Finland
Strabismus, Concomitans divergens
+∞
28.2
27
*
H26.02
ICD-10 Finland
Presenil cataract
7.8
27.0
63
85
H50.30
ICD-10 Finland
Intermittent esotropy
266.9
25.8
26
*
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
+∞
25.1
24
*
H25.8
ICD-10 Finland
Other senile cataract
3.1
23.7
143
513
CGD20
NOMESCO Finland
Laser-assisted in situ keratomileusis
127.9
23.7
25
*
H52.4
ICD-10 Finland
Presbyopia
11.5
23.1
43
39
H50.2
ICD-10 Finland
Vertical strabismus
+∞
23.0
22
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.8
18.6
130
508
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
19.8
18.2
27
14
H33.0
ICD-10 Finland
Retinal detachment with retinal break
5.9
17.7
50
89
XCK00
NOMESCO Finland
Perimetry
3.3
17.7
93
302
WX140
NOMESCO Finland
Parabulbar anesthesy
4.3
17.2
64
155
S01BA07
ATC
fluorometholone; ophthalmic (corticosteroids, plain)
7.0
17.1
42
62
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.2
16.8
191
966
H53.2
ICD-10 Finland
Diplopia
6.2
16.5
44
73
CG2T4
NOMESCO Finland
Topography assessment of cornea
15.6
16.2
26
17
H50.52
ICD-10 Finland
Exophoria
27.6
14.3
19
7
3673A
ICD-9 Finland
Disorders of refraction and accommodation, Anisometropia and aniseikonia
+∞
13.6
13
*
37600
ICD-8 Finland
Detachment of retina, Primaria
141.7
13.5
14
*
37300
ICD-8 Finland
Strabismus, Concomitans convergens
+∞
12.5
12
*
37303
ICD-8 Finland
Strabismus, Heterophoria (exophoria, esophroria, hypophoria)
+∞
11.5
11
*
H50.51
ICD-10 Finland
Esophoria
121.3
11.4
12
*
CJF10
NOMESCO Finland
Secondary implantation of artificial lens in posterior chamber
121.3
11.4
12
*
H44.2
ICD-10 Finland
Degenerative myopia
35.4
11.3
14
*
XCK10
NOMESCO Finland
Photography of fundus of eye
2.3
10.9
104
482
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
+∞
10.4
10
*
CEC00
NOMESCO Finland
Recession of extraocular muscle
+∞
10.4
10
*
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
3.8
10.3
42
113
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.1
10.2
116
582
H53.1
ICD-10 Finland
Subjective visual disturbances
2.6
10.1
72
287
ZXA00
NOMESCO Finland
Right side
1.6
9.1
247
1664
H26.2
ICD-10 Finland
Complicated cataract
5.9
8.6
23
40
S01ED51
ATC
timolol, combinations; ophthalmic
2.4
8.6
72
314
H04.10
ICD-10 Finland
Dry eye syndrome
2.1
8.6
96
478
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.6
8.5
62
251
3671A
ICD-9 Finland
Disorders of refraction and accommodation, Myopia
+∞
8.3
8
*
H49.1
ICD-10 Finland
Fourth [trochlear] nerve palsy
+∞
8.3
8
*
37602
ICD-8 Finland
Detachment of retina, Foramen, ruptura retinae
+∞
8.3
8
*
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
25.2
7.6
10
*
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
3.2
7.5
37
118
WX110
NOMESCO Finland
Local anesthesy
1.5
7.5
667
5750
3680A
ICD-9 Finland
Visual disturbances, Amblyopia ex anopsia
80.6
7.4
8
*
3503
FHL
Single muscle retroposition
+∞
7.3
7
*
CEW99
NOMESCO Finland
Other operation on extraocular muscle
+∞
7.3
7
*
S01EE01
ATC
latanoprost; ophthalmic
2.4
7.3
58
248
N03AG01
ATC
valproic acid; systemic, rectal
2.4
7.3
60
261
H54.5
ICD-10 Finland
Severe visual impairment, monocular
15.9
7.2
11
7
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
3.8
7.1
28
75
114
Kela drug reimbursment
Glaucoma
2.1
7.0
76
377
ZXA10
NOMESCO Finland
Bilateral
1.6
6.6
173
1141
H53.8
ICD-10 Finland
Other visual disturbances
5.2
6.6
19
37
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
7.5
6.4
14
19
H16.0
ICD-10 Finland
Corneal ulcer
2.5
6.4
48
199
37000
ICD-8 Finland
Refractive errors, Astigmatismus
+∞
6.3
6
*
CEC60
NOMESCO Finland
Transposition of extraocular muscle with adjustable suture
+∞
6.3
6
*
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
+∞
6.3
6
*
37003
ICD-8 Finland
Refractive errors, Anisometropia
+∞
6.3
6
*
H40.0
ICD-10 Finland
Glaucoma suspect
2.1
6.2
68
338
WX002
NOMESCO Finland
Sedation and analgesia
1.6
6.1
175
1182
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.0
6.1
77
404
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
2.5
6.0
43
174
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
138
738
1.99
11.73
4.7
3.8
1.2
1.2
mmol/l
0.06
105
642
971
8870
1.55
7.33
5.3
4.7
1.8
2.0
mu/l
1.02
860
8139
484
3917
1.40
7.14
2.7
2.3
77.6
76.5
nmol/l
0.35
419
3510
149
947
1.66
7.10
3.9
3.2
—
—
—
0
0
549
4633
1.35
5.87
7.5
6.8
1.2
1.2
mmol/l
0.08
425
3941
832
7515
1.37
5.49
4.5
3.9
14.9
14.7
pmol/l
1.59
729
6830
500
4232
1.32
4.97
7.9
6.1
1.2
1.2
mmol/l
0.13
434
3843
699
6198
1.32
4.94
3.3
3.1
49.7
45.9
u/l
0.28
632
5808
141
975
1.51
4.68
5.6
4.1
263.3
252.8
u/l
0.19
132
927
777
7032
1.31
4.52
4.2
4.0
11.5
11.9
mm/h
0.40
690
6507
39
192
2.07
4.27
2.1
2.5
16.0
16.2
%
0.07
18
105
272
2148
1.35
4.27
1.5
1.5
21.8
21.1
nmol/l
0.32
220
1820
107
712
1.55
4.24
2.4
3.1
65.8
66.6
g/l
0.56
96
651
403
3372
1.30
4.18
3.8
3.6
36.5
46.5
ng/l
0.35
259
2260
1026
9731
1.44
4.05
17.5
15.3
139.4
139.6
mmol/l
1.05
992
9460
26
112
2.35
3.94
1.8
2.0
32.7
32.9
pg
0.09
26
112
373
3111
1.29
3.92
3.2
3.3
2.4
2.4
mmol/l
0.23
321
2715
98
655
1.54
3.83
1.4
1.3
170.4
240.6
u/ml
0.58
91
602
31
146
2.15
3.83
1.5
1.6
0.3
0.3
nmol/l
0.02
25
117
325
2674
1.30
3.77
3.6
3.0
0.8
0.5
e6/l
0.41
235
2017
1026
9757
1.41
3.74
17.6
15.4
3.9
4.0
mmol/l
0.35
986
9469
53
312
1.73
3.44
15.9
7.4
1.4
1.4
mg/l
0.17
48
289
932
8767
1.31
3.38
14.0
12.1
82.9
83.4
ml/min/173m2
0.23
749
7103
238
1908
1.31
3.31
1.9
1.7
486.2
33797023.7
pmol/l
2.16
166
1583
774
7129
1.25
3.27
7.5
7.1
82.8
80.0
u/l
0.46
703
6693
89
609
1.50
3.16
3.4
3.0
4.4
4.6
pmol/l
0.90
78
533
102
721
1.45
3.08
1.3
1.2
154.8
152.2
iu/ml
0.02
33
290
892
8388
1.27
2.95
5.8
5.5
38.7
39.5
mmol/mol
1.82
794
7796
609
5502
1.22
2.93
5.6
4.8
6.6
6.6
mmol/l
0.27
564
5109
148
1130
1.35
2.88
4.2
4.3
31.4
32.2
%
0.36
98
762
444
3901
1.22
2.77
4.7
4.8
35.6
35.7
g/l
0.28
396
3614
206
1659
1.29
2.76
1.9
1.7
1274.2
1190.6
nmol/l
0.51
124
1230
13
48
2.73
2.72
1.4
1.7
—
—
—
0
0
530
4748
1.21
2.70
5.9
6.1
12.4
11.6
umol/l
0.39
481
4485
334
2860
1.23
2.65
2.6
2.4
54.2
56.3
u/l
0.47
287
2638
12
43
2.81
2.65
1.4
2.0
—
—
—
0
0
13
49
2.67
2.62
1.4
1.7
—
—
—
0
0
123
928
1.36
2.59
2.2
2.1
364.9
379.8
nmol/l
0.35
113
840
22
108
2.06
2.52
3.9
2.7
24.2
22.3
nmol/l
0.17
22
102
391
3420
1.21
2.51
3.8
3.2
—
—
—
0
0
180
1444
1.29
2.48
3.0
2.4
13.6
13.1
umol/l
0.39
164
1337
58
384
1.54
2.45
1.5
2.1
36.2
39.9
u/l
0.72
52
347
421
3717
1.21
2.44
2.1
1.9
102.0
95.0
pmol/l
1.65
221
1903
523
4713
1.20
2.43
4.4
3.6
0.0
0.0
estimate
0.00
130
920
45
283
1.61
2.37
1.5
1.4
284.9
299.8
ug/g
0.21
28
171
1047
10116
1.33
2.35
10.9
9.9
26.2
25.4
u/l
0.54
983
9751
63
430
1.49
2.32
1.5
1.5
23.8
26.7
iu/l
0.33
53
350
12
47
2.57
2.27
2.3
2.3
1056.3
795.3
u/ml
0.30
12
47
528
4787
1.19
2.23
4.6
3.6
0.0
0.0
estimate
0.80
128
899
160
1284
1.28
2.21
2.2
2.3
126.1
128.8
ug/g
0.03
105
984
22
114
1.95
2.21
1.5
1.8
—
—
—
0
0
1108
10821
1.44
2.13
23.0
19.6
6.7
6.8
e9/l
0.68
1065
10499
942
9014
1.23
2.10
17.2
14.5
39.2
39.6
%
0.69
668
6670
291
2514
1.21
2.07
4.5
3.9
0.0
0.0
estimate
0.88
125
900
247
2100
1.22
2.07
2.2
1.9
1.3
1.2
mg/l
0.12
177
1593
266
2279
1.22
2.06
2.9
2.8
1952.8
5832.8
umol/l
1.38
220
1990
346
3042
1.19
2.04
2.8
3.3
32.4
31.8
u/l
0.07
322
2900
1107
10818
1.42
2.03
22.9
19.6
4.5
4.5
e12/l
1.30
1062
10499
520
4737
1.18
2.02
6.4
5.0
0.0
0.0
estimate
0.50
128
932
52
353
1.49
2.00
1.4
1.7
2.5
4.7
mg/l
0.73
40
261
1106
10812
1.41
1.96
23.0
19.6
259.8
254.3
e9/l
1.82
1068
10521
1107
10824
1.41
1.96
23.1
19.7
133.5
134.4
g/l
1.20
1083
10661
161
1316
1.26
1.93
3.0
2.4
2.4
2.4
g/l
0.23
145
1221
909
8690
1.20
1.92
3.9
3.8
1.3
1.3
mmol/l
0.20
799
7964
53
365
1.47
1.92
2.7
1.9
1.5
1.5
g/l
0.27
46
328
17
85
2.01
1.90
1.2
1.2
0.0
1.2
u/ml
—
5
31
45
300
1.52
1.90
3.8
3.7
3.2
3.5
g/l
0.63
45
285
608
5627
1.17
1.90
9.6
8.9
4.0
4.1
e9/l
0.46
525
4902
282
2452
1.20
1.87
2.4
2.2
3.0
3.0
mg/l
0.02
217
2082
74
545
1.38
1.87
1.6
1.5
—
—
—
0
0
6
17
3.54
1.84
3.0
1.9
—
—
—
0
0
41
270
1.54
1.83
1.3
1.2
26.9
33.7
u/ml
—
5
14
281
2449
1.19
1.81
1.3
1.4
2.2
2.0
u/ml
0.09
73
619
39
255
1.55
1.80
1.3
1.2
7.1
8.8
u/ml
—
8
41
13
60
2.18
1.78
1.4
1.6
—
—
—
0
0
174
1450
1.23
1.77
5.8
4.0
0.8
0.8
mmol/l
0.39
158
1361
47
322
1.48
1.76
1.7
1.6
—
—
—
0
0
14
67
2.10
1.76
1.5
1.8
—
—
—
0
0
182
1528
1.23
1.73
3.1
2.9
3.9
2.9
e6/l
0.46
90
820
7
24
2.93
1.72
1.4
2.4
13.5
15.0
umol/l
—
7
24
108
855
1.29
1.70
2.5
2.5
0.2
0.2
g/l
0.60
100
805
479
4390
1.15
1.63
3.4
2.8
125.0
106.8
ug/l
0.36
426
4047
129
1051
1.26
1.62
2.5
3.2
10.1
8.0
umol/l
0.37
108
897
194
1652
1.21
1.61
2.7
2.9
2.5
2.5
mmol/l
0.25
168
1449
281
2480
1.17
1.56
1.5
1.6
1.3
1.4
mmol/l
0.31
209
2101
997
9665
1.21
1.56
15.4
13.3
21.4
23.4
mg/l
1.14
777
7533
930
8961
1.18
1.55
4.6
4.3
5.8
5.9
mmol/l
1.89
806
8142
307
2731
1.17
1.54
2.2
2.1
281.7
220.5
u/l
0.27
278
2581
8
33
2.43
1.54
1.1
1.1
—
—
—
0
0
20
115
1.75
1.53
1.4
1.6
—
—
—
0
0
147
1224
1.23
1.52
3.2
2.4
23.2
22.5
%
0.23
127
1049
942
9090
1.18
1.52
4.4
4.2
4.6
4.7
mmol/l
0.25
826
8428
180
2102
0.83
1.52
3.7
3.9
1.0
1.0
kg/l
0.19
36
316
41
287
1.44
1.42
1.6
1.6
9.2
9.9
u/l
0.14
33
215
18
103
1.76
1.41
1.2
1.1
—
—
—
0
0
26
165
1.59
1.41
1.4
1.8
—
—
—
0
0
935
9035
1.17
1.40
4.4
4.2
1.5
1.5
mmol/l
0.19
820
8327
91
725
1.28
1.40
6.7
4.8
5.2
5.1
kpa
0.53
82
685
399
3643
1.14
1.39
4.8
3.8
—
—
—
0
0
39
274
1.44
1.34
1.6
1.6
—
—
—
0
0
9
42
2.15
1.33
1.6
2.1
27.1
208.6
ug/l
—
9
37
61
465
1.33
1.30
3.0
2.3
4641.8
3912.0
u/l
0.09
24
183
32
218
1.48
1.29
1.8
1.6
—
—
—
0
0
21
130
1.63
1.27
1.3
1.6
—
—
—
0
0
6
25
2.41
1.24
1.0
1.7
—
—
—
0
0
54
408
1.34
1.24
9.3
3.2
0.6
0.6
%
0.09
54
394
22
335
0.65
1.20
1.4
1.4
—
—
—
0
0
41
298
1.39
1.19
1.6
1.6
0.2
0.0
iu/ml
—
10
55
86
696
1.25
1.19
6.9
4.8
1.5
1.7
mmol/l
0.17
65
516
32
223
1.45
1.17
1.5
1.7
—
—
—
0
0
8
39
2.06
1.15
1.0
1.1
104.9
95.3
%
—
8
34
952
9252
1.15
1.14
4.8
4.7
2.8
2.8
mmol/l
0.02
833
8520
255
2289
1.15
1.13
4.8
4.9
2.2
3.1
ug/l
1.14
220
2051
7
30
2.34
1.12
1.1
1.1
—
—
—
0
0
8
40
2.01
1.12
1.0
1.1
154.8
200.3
iu/ml
—
8
40
10
51
1.97
1.11
1.6
1.9
—
—
—
0
0
10
51
1.97
1.11
1.6
1.9
—
—
—
0
0
40
294
1.37
1.11
1.6
1.3
—
—
—
0
0
7
31
2.27
1.10
1.0
1.1
—
—
—
0
0
7
31
2.27
1.10
1.0
1.1
—
—
—
0
0
7
138
0.50
1.10
1.3
1.1
—
—
—
0
0
12
66
1.83
1.09
1.2
1.2
—
—
—
0
0
155
1344
1.18
1.09
2.8
3.0
0.7
0.8
ug/l
0.38
100
883
21
136
1.55
1.09
1.4
1.6
—
—
—
0
0
32
227
1.42
1.08
1.5
1.7
—
—
—
0
0
187
1648
1.16
1.07
1.3
1.4
—
—
—
0
0
24
161
1.50
1.07
1.5
1.6
—
—
—
0
0
20
129
1.56
1.06
1.2
1.4
6.9
7.5
mmol/l
0.51
13
88
12
67
1.80
1.05
1.2
1.2
—
—
—
0
0
226
2024
1.14
1.04
3.3
2.4
8.3
6.8
e6/l
0.64
191
1786
145
1257
1.18
1.03
9.1
5.9
1.1
1.1
mmol/l
1.11
137
1162
13
75
1.74
1.03
1.2
1.5
—
—
—
0
0
254
2304
1.13
0.97
2.9
2.3
—
—
—
0
0
10
54
1.86
0.96
1.2
1.9
—
—
—
0
0
78
643
1.23
0.95
1.9
1.6
—
—
—
0
0
18
117
1.55
0.94
1.6
1.4
—
—
—
0
0
18
117
1.55
0.94
1.6
1.4
—
—
—
0
0
46
357
1.30
0.93
1.5
1.8
—
—
—
0
0
6
28
2.15
0.91
1.0
1.1
—
—
—
0
0
6
28
2.15
0.91
1.0
1.1
—
—
—
0
0
180
1603
1.15
0.91
1.3
1.3
19.5
35.4
iu/ml
2.22
48
493
18
118
1.53
0.91
1.5
1.4
—
—
—
0
0
18
118
1.53
0.91
1.6
1.4
—
—
—
0
0
27
193
1.41
0.91
1.3
1.3
—
—
—
0
0
27
193
1.41
0.91
1.3
1.3
—
—
—
0
0
17
110
1.55
0.91
1.1
1.1
—
—
—
0
0
58
716
0.80
0.90
2.2
2.4
7.1
6.7
ug/l
0.07
44
633
8
42
1.91
0.88
1.0
1.1
1145.5
1745.3
miu/ml
—
8
42
30
220
1.37
0.88
1.5
1.7
44.2
40.0
nmol/l
0.47
30
209
6
30
2.00
0.87
1.0
1.2
11.0
8.8
ug/l
—
6
30
6
30
2.00
0.87
1.3
1.6
—
—
—
0
0
35
264
1.34
0.86
1.7
4.1
50.1
72.5
mg/l
0.41
24
213
8
44
1.82
0.86
1.8
1.2
24.4
28.2
nmol/l
—
8
37
180
1611
1.14
0.85
3.0
2.7
1.0
1.1
e6/l
0.10
88
893
18
120
1.51
0.85
1.6
1.4
—
—
—
0
0
6
31
1.94
0.84
1.0
1.2
—
—
—
0
0
37
283
1.32
0.84
1.0
1.1
1.5
8.7
u/ml
—
5
38
22
154
1.44
0.83
1.0
1.1
2.2
5.1
u/ml
—
9
61
687
6606
1.10
0.83
3.4
3.2
—
—
—
0
0
13
81
1.61
0.81
1.2
1.0
—
—
—
0
0
71
593
1.21
0.80
2.1
2.1
12.7
12.1
nmol/l
0.22
57
516
20
139
1.45
0.79
1.5
1.7
—
—
—
0
0
26
190
1.38
0.79
6.7
6.9
142.4
330.0
iu/ml
—
5
29
6
33
1.82
0.79
1.0
1.1
88.5
93.2
%
—
6
33
6
33
1.82
0.79
1.0
1.0
3.5
3.1
kpa
—
6
24
6
33
1.82
0.79
1.0
1.1
—
—
—
0
0
27
199
1.37
0.78
1.4
1.4
—
—
—
0
0
15
222
0.67
0.78
1.3
1.9
12304.6
13791.0
e6/l
—
9
168
309
2872
1.10
0.77
3.4
3.2
7.1
7.6
mmol/l
0.89
235
2441
6
34
1.77
0.76
1.0
1.0
6.4
7.9
kpa
—
6
25
21
149
1.42
0.76
1.3
1.2
8.2
2.3
u/ml
0.38
12
42
7
38
1.85
0.73
1.1
1.3
—
—
—
0
0
39
308
1.28
0.73
1.3
1.1
—
—
—
0
0
9
56
1.61
0.72
1.0
1.1
—
—
—
0
0
34
264
1.30
0.72
1.8
4.1
28.5
33.2
mg/l
0.36
23
214
19
134
1.42
0.71
1.0
1.1
5.1
0.7
u/ml
—
5
34
42
336
1.26
0.71
1.8
1.9
0.9
2.3
ug/l
0.77
34
296
95
826
1.16
0.70
1.7
1.6
—
—
—
0
0
38
301
1.27
0.70
1.4
1.8
—
—
—
0
0
7
41
1.71
0.70
1.0
1.0
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
9
58
1.56
0.70
1.0
1.1
—
—
—
0
0
32
248
1.30
0.69
2.0
1.8
2.6
4.5
iu/l
—
10
87
16
110
1.46
0.68
1.1
1.1
—
—
—
0
0
38
303
1.26
0.67
1.4
1.3
—
—
—
0
0
17
119
1.43
0.67
1.6
1.4
—
—
—
0
0
86
988
0.86
0.66
10.2
7.5
0.3
1.1
mmol/l
1.14
70
780
5
28
1.79
0.66
1.0
1.0
—
—
—
0
0
5
29
1.73
0.64
4.0
4.9
—
—
—
0
0
100
883
1.14
0.62
3.6
4.1
96.5
25.2
ug/l
0.38
79
729
270
2526
1.09
0.59
3.4
3.1
1548.9
1300.6
ng/l
0.37
226
2149
14
97
1.45
0.59
1.1
1.7
—
—
—
0
0
34
273
1.25
0.58
1.7
2.8
—
—
—
0
0
77
671
1.16
0.58
2.9
2.6
67.4
68.0
ml/min/173m2
0.04
39
264
844
8252
1.08
0.57
18.9
16.3
13.6
13.6
%
0.12
823
8070
63
730
0.86
0.56
2.7
3.1
105.5
199.7
ng/l
4.15
54
673
29
230
1.27
0.55
2.0
1.8
1693.4
745.0
e6/l
0.35
22
179
29
230
1.27
0.55
1.9
1.8
13.0
13.5
e6/l
0.02
21
170
10
65
1.54
0.55
1.1
1.2
—
—
—
0
0
39
322
1.22
0.54
2.9
2.5
3.5
3.8
g/l
1.13
33
236
39
323
1.21
0.52
2.9
2.5
7.2
7.4
g/l
0.34
33
247
39
323
1.21
0.52
2.9
2.5
—
—
—
0
0
9
63
1.43
0.52
1.1
1.4
5.2
4.6
umol/l
—
9
57
30
243
1.24
0.50
1.6
1.7
—
—
—
0
0
19
145
1.32
0.49
1.2
1.1
—
—
—
0
0
14
189
0.74
0.48
1.3
1.6
—
—
—
0
0
32
263
1.22
0.47
1.5
1.6
—
—
—
0
0
19
146
1.31
0.47
2.8
3.5
1.1
1.5
%
0.37
11
126
29
236
1.23
0.47
1.2
1.2
—
—
—
0
0
96
865
1.12
0.46
2.6
2.3
37.7
33.5
u/l
0.26
77
723
15
111
1.36
0.46
1.1
1.7
—
—
—
0
0
7
50
1.40
0.45
1.3
1.1
238.4
72.1
u/l
—
7
45
27
220
1.23
0.44
2.2
2.2
120.1
131.0
g/l
1.19
19
164
11
78
1.41
0.43
3.7
2.9
—
—
—
0
0
8
56
1.43
0.42
1.3
1.3
—
—
—
0
0
8
56
1.43
0.42
1.3
1.3
—
—
—
0
0
19
149
1.28
0.42
1.0
1.1
—
—
—
0
0
20
250
0.80
0.41
1.2
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.8
—
—
—
0
0
11
80
1.38
0.38
1.2
1.1
—
—
—
0
0
11
80
1.38
0.38
1.2
1.1
—
—
—
0
0
11
80
1.38
0.38
1.2
1.1
—
—
—
0
0
11
80
1.38
0.38
1.2
1.1
—
—
—
0
0
5
37
1.35
0.37
1.0
1.3
—
—
—
0
0
5
37
1.35
0.37
1.4
3.2
33.4
32.2
umol/l
—
5
28
5
37
1.35
0.37
2.0
1.5
—
—
—
0
0
11
81
1.36
0.36
1.2
1.1
—
—
—
0
0
78
708
1.11
0.36
4.9
4.0
107.3
78.5
ng/l
0.57
61
628
20
162
1.24
0.35
4.2
3.4
749.1
1835.3
u/ml
0.30
20
153
6
42
1.43
0.35
1.0
1.0
19.5
19.3
mmol/l
—
6
35
19
153
1.25
0.35
1.3
1.2
3.4
6.8
u/ml
—
10
67
14
108
1.30
0.35
1.1
1.1
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
32
273
1.18
0.35
4.7
3.8
0.4
0.4
u/ml
0.00
18
146
10
73
1.37
0.34
2.2
1.4
—
—
—
0
0
6
44
1.37
0.34
1.5
2.4
—
—
—
0
0
101
1090
0.92
0.33
20.0
23.2
1.0
1.3
inr
—
9
143
6
47
1.28
0.32
1.3
1.3
—
—
—
0
0
6
47
1.28
0.32
1.3
1.3
—
—
—
0
0
19
230
0.82
0.31
2.3
1.4
—
—
—
0
0
158
1491
1.07
0.31
1.7
1.9
—
—
—
0
0
23
193
1.20
0.31
1.3
1.5
—
—
—
0
0
12
153
0.78
0.31
1.6
1.7
—
—
—
0
0
123
1154
1.07
0.29
2.1
1.7
1.4
1.5
%
0.92
102
1024
59
538
1.10
0.27
13.3
9.2
0.7
0.7
%
0.39
59
533
15
122
1.23
0.27
1.5
1.2
54.0
0.6
nmol/l
0.48
15
116
65
597
1.09
0.26
1.0
1.1
—
—
—
0
0
11
86
1.28
0.26
2.1
2.6
—
—
—
0
0
10
77
1.30
0.26
1.0
1.2
—
—
—
0
0
9
72
1.25
0.25
1.3
1.3
—
—
—
0
0
59
541
1.10
0.25
13.3
9.1
1.2
1.4
%
0.57
59
536
458
4475
1.04
0.24
4.4
4.0
—
—
—
0
0
12
96
1.25
0.24
1.2
1.1
—
—
—
0
0
6
82
0.73
0.24
2.3
2.5
—
—
—
0
0
20
233
0.86
0.24
1.6
1.4
62.3
208.7
pmol/l
1.40
20
226
22
190
1.16
0.23
1.5
1.7
—
—
—
0
0
5
39
1.28
0.23
1.0
1.2
79.0
95.0
nmol/l
—
5
29
60
554
1.09
0.22
1.5
1.6
—
—
—
0
0
22
191
1.15
0.22
2.2
1.6
100.6
106.4
u/ml
—
5
36
28
248
1.13
0.21
1.1
1.1
0.2
1.8
u/ml
—
8
109
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
2.2
—
3.6
—
0
12
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
19
219
0.87
0.20
2.3
1.4
173.3
258.0
u/ml
1.80
12
128
277
2691
1.04
0.20
4.3
3.9
7.3
9.1
mg/mmol
0.38
149
1699
28
313
0.89
0.20
1.5
1.5
—
—
—
0
0
6
49
1.23
0.20
1.2
1.0
—
—
—
0
0
113
1076
1.06
0.19
6.3
6.7
—
—
—
0
0
52
561
0.92
0.19
1.4
1.5
—
—
—
0
0
6
53
1.13
0.18
1.2
1.4
6.3
6.1
mmol/l
—
6
53
7
59
1.19
0.18
1.7
1.6
—
—
—
0
0
38
348
1.09
0.18
1.5
1.3
204.4
256.0
miu/ml
0.51
20
175
7
60
1.17
0.17
1.4
1.3
—
—
—
0
0
5
66
0.76
0.17
1.0
1.7
1.0
1.1
g/l
—
5
66
18
158
1.14
0.16
1.3
3.1
17.0
9.4
umol/l
0.22
11
117
11
92
1.20
0.16
6.8
4.4
60.4
95.5
u/ml
—
6
29
8
72
1.11
0.16
3.5
1.7
—
—
—
0
0
108
1035
1.05
0.16
1.6
1.8
—
—
—
0
0
15
130
1.16
0.15
1.3
1.2
—
—
—
0
0
9
83
1.08
0.14
1.0
1.0
—
—
—
0
0
27
249
1.09
0.12
1.4
1.3
—
—
—
0
0
87
839
1.04
0.11
2.4
2.0
—
—
—
0
0
171
1750
0.97
0.10
2.8
3.7
242.0
391.6
ng/l
0.72
124
1310
19
208
0.91
0.10
2.3
2.5
87.6
100.0
ug/min
—
8
126
16
177
0.90
0.10
1.3
1.2
—
—
—
0
0
11
96
1.15
0.10
3.4
3.8
—
—
—
0
0
36
339
1.06
0.10
2.4
3.4
52.4
1324.6
u/ml
1.53
29
287
38
359
1.06
0.10
1.4
1.4
—
—
—
0
0
22
203
1.09
0.09
3.2
3.5
25.7
25.0
mg/l
0.05
12
127
136
1327
1.03
0.09
2.4
2.2
—
—
—
0
0
19
174
1.09
0.09
1.2
1.1
—
—
—
0
0
16
145
1.10
0.09
1.2
1.3
—
—
—
0
0
5
48
1.04
0.09
1.6
3.6
—
—
—
0
0
142
1453
0.97
0.09
2.6
2.3
—
—
—
0
0
6
54
1.11
0.09
2.0
1.6
—
—
—
0
0
12
134
0.89
0.08
1.2
1.2
—
—
—
0
0
47
449
1.05
0.08
14.2
9.8
23.7
24.3
mmol/l
0.82
47
420
6
57
1.05
0.08
1.3
1.4
—
250.0
—
0
6
107
1043
1.03
0.08
1.7
1.8
—
—
—
0
0
7
80
0.87
0.07
1.9
1.8
—
—
—
0
0
35
334
1.05
0.06
1.8
1.8
—
—
—
0
0
38
367
1.04
0.04
1.7
1.9
—
—
—
0
0
33
320
1.03
0.03
1.2
1.4
—
—
—
0
0
156
1547
1.01
0.02
1.3
1.2
7.7
12.1
u/ml
0.54
56
573
12
113
1.06
0.01
1.4
1.2
—
—
—
0
0
70
692
1.01
0.01
2.1
1.8
—
—
—
0
0
29
297
0.98
0.01
1.2
1.2
—
—
—
0
0
12
114
1.05
0.00
1.0
1.0
—
—
—
0
0
22
214
1.03
0.00
1.4
1.5
—
—
—
0
0
27
276
0.98
0.00
1.5
1.4
—
—
—
0
0
27
276
0.98
0.00
1.5
1.4
—
—
—
0
0
36
366
0.98
0.00
1.7
1.8
—
—
—
0
0
59
596
0.99
0.00
1.4
1.3
—
—
—
0
0
12
115
1.04
0.00
1.2
1.6
66.7
59.7
%
—
6
84
18
182
0.99
0.00
3.7
2.9
0.7
0.8
nmol/l
1.41
12
143
30
295
1.02
0.00
1.2
1.2
—
—
—
0
0
184
1838
1.00
0.00
3.5
4.3
22.8
21.0
%
0.88
86
876
210
2103
1.00
0.00
1.8
1.6
—
—
—
0
0
95
953
1.00
0.00
11.2
4.4
1.6
1.9
mmol/l
0.26
77
749
27
275
0.98
0.00
1.5
1.4
—
—
—
0
0
27
275
0.98
0.00
1.5
1.4
—
—
—
0
0
5
58
0.86
0.00
2.6
2.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
7
79
0.89
0.00
1.0
1.6
—
—
—
0
0
5
59
0.85
0.00
1.6
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
4.1
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
7
79
0.89
0.00
1.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
382.6
—
0
5
7
79
0.89
0.00
1.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
7
77
0.91
0.00
1.9
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
14.0
—
0
7
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
8
81
0.99
0.00
1.1
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_ANISOMETROPIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_ANISOMETROPIA | 0.844 [0.73, 0.97] | 0.021 |
| Birth year | 0.992 [0.98, 1.0] | 0.089 |
During the follow-up period (1.1.1998 — 31.12.2019), 417 out of 5603 females with H7_ANISOMETROPIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_ANISOMETROPIA | 1.023 [0.85, 1.22] | 0.807 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 288 out of 4430 males with H7_ANISOMETROPIA died.
Mortality risk
Mortality risk for people of age
years, who have H7_ANISOMETROPIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.097% | 0.203% |
| 5 | 0.511% | 1.122% |
| 10 | 1.205% | 2.815% |
| 15 | 2.278% | 5.208% |
| 20 | 3.952% | 8.999% |
Relationships between endpoints
↥Index endpoint: H7_ANISOMETROPIA – Anisometropia and aniseikonia
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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