Corneal scars and opacities

H7_CORNEALSCAR

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H17
  • Hospital discharge: ICD-9 3710
  • Cause of death: ICD-10 H17
  • Cause of death: ICD-9 3710

2 out of 7 registries used, show all original rules.

946

4. Check minimum number of events

None

946

5. Include endpoints

None

946

6. Filter based on genotype QC (FinnGen only)

946

Control definitions (FinnGen only)

Control exclude
H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H15-H22
Name in latin
Cicatrices et opacitates corneae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7698 3908 3727
Only index persons 6810 3444 3366
Unadjusted period prevalence (%)
Whole population 0.11 0.11 0.10
Only index persons 0.13 0.13 0.13
Median age at first event (years)
Whole population 61.16 67.07 54.84
Only index persons 59.45 65.16 53.60

-FinnGen-

Key figures

All Female Male
Number of individuals 946 493 453
Unadjusted period prevalence (%) 0.18 0.17 0.20
Median age at first event (years) 60.68 60.11 61.30

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
826
Matched controls
8258
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
+∞
311.8
279
*
H17.8
ICD-10 Finland
Other corneal scars and opacities
+∞
309.4
277
*
H17.1
ICD-10 Finland
Other central corneal opacity
+∞
296.2
266
*
H16.0
ICD-10 Finland
Corneal ulcer
60.5
173.4
202
44
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
6.3
130.1
575
2201
CG2T4
NOMESCO Finland
Topography assessment of cornea
164.9
110.3
114
8
H16.9
ICD-10 Finland
Keratitis, unspecified
1160.1
106.8
102
*
Z94.7
ICD-10 Finland
Corneal transplant status
+∞
90.3
85
*
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
172.2
89.1
92
6
CG2S4
NOMESCO Finland
Photography of cornea
145.8
86.9
91
7
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
907.1
85.2
82
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
4.3
83.1
451
1794
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.6
81.8
238
475
S01AD03
ATC
aciclovir; ophthalmic
16.9
79.4
130
90
H17.0
ICD-10 Finland
Adherent leukoma
+∞
71.9
68
*
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
+∞
69.8
66
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
5.1
62.6
229
581
H18.8
ICD-10 Finland
Other specified disorders of cornea
313.2
58.0
58
*
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
55.9
53
*
H18.4
ICD-10 Finland
Corneal degeneration
+∞
55.9
53
*
XCK10
NOMESCO Finland
Photography of fundus of eye
5.2
53.0
184
432
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
540.3
52.1
51
*
TCG10
NOMESCO Finland
Removal of sutures from cornea
76.2
50.7
57
8
H04.10
ICD-10 Finland
Dry eye syndrome
5.1
46.9
163
379
WX100
NOMESCO Finland
Conjunctival surface anesthesia
4.4
42.5
173
471
CGD10
NOMESCO Finland
Laser keratoplasty for error of refraction
69.4
40.5
46
7
H16.2
ICD-10 Finland
Keratoconjunctivitis
405.8
39.4
39
*
3710A
ICD-9 Finland
Corneal opacity and other disorders of cornea, Corneal scars and opacities
+∞
38.9
37
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.4
35.5
205
738
WX140
NOMESCO Finland
Parabulbar anesthesy
7.1
34.3
87
134
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.6
33.0
323
1628
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
4.1
30.0
125
341
ZXA10
NOMESCO Finland
Bilateral
2.8
29.6
223
952
H25.1
ICD-10 Finland
Senile nuclear cataract
2.5
28.1
272
1338
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
31.3
27.4
36
12
H20.1
ICD-10 Finland
Chronic iridocyclitis
+∞
26.2
25
*
H19.1
ICD-10 Finland
Herpesviral keratitis and keratoconjunctivitis
+∞
26.2
25
*
CFD10
NOMESCO Finland
Repair of conjunctiva
139.4
25.8
27
*
H27.0
ICD-10 Finland
Aphakia
139.4
25.8
27
*
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
60.0
25.1
29
5
S01ED01
ATC
timolol; ophthalmic
6.1
25.0
70
123
H18.6
ICD-10 Finland
Keratoconus
257.5
24.8
25
*
CD2S4
NOMESCO Finland
Photography of eye
50.0
24.4
29
6
S01ED51
ATC
timolol, combinations; ophthalmic
4.2
24.4
99
262
3604
FHL
Penetration of the cornea
+∞
24.1
23
*
H17
ICD-10 Finland
Corneal scars and opacities
+∞
24.1
23
*
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
5.5
24.1
73
142
H52.2
ICD-10 Finland
Astigmatism
14.4
23.8
40
29
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
7.0
23.7
60
92
S01BC03
ATC
diclofenac; ophthalmic
8.1
22.1
50
65
S01BA07
ATC
fluorometholone; ophthalmic (corticosteroids, plain)
10.7
21.8
42
41
CGE10
NOMESCO Finland
Keratectomy
225.7
21.7
22
*
H19.2*B02.3
ICD-10 Finland
Keratitis and keratoconjunctivitis (interstitial) in zoster
+∞
20.9
20
*
H18.1
ICD-10 Finland
Bullous keratopathy
+∞
20.9
20
*
H16.4
ICD-10 Finland
Corneal neovascularization
+∞
20.9
20
*
TCG30
NOMESCO Finland
Imaging of anterior and posterior part of cornea
+∞
20.9
20
*
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
10.4
20.0
39
39
CGG99
NOMESCO Finland
Other reconstructive operations on cornea and sclera
+∞
19.9
19
*
ZZL00
NOMESCO Finland
Free graft of amniotic membrane
+∞
19.9
19
*
CG2Z4
NOMESCO Finland
Specialised imaging of cornea
+∞
19.9
19
*
WX002
NOMESCO Finland
Sedation and analgesia
2.4
19.7
203
1001
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.0
19.5
81
218
H16.1
ICD-10 Finland
Other superficial keratitis without conjunctivitis
+∞
18.8
18
*
H16.8
ICD-10 Finland
Other keratitis
+∞
18.8
18
*
H26.2
ICD-10 Finland
Complicated cataract
14.6
18.7
31
22
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.2
17.9
100
341
S01EC01
ATC
acetazolamide; systemic
7.9
17.6
40
53
XCK00
NOMESCO Finland
Perimetry
3.7
17.1
78
228
H33.0
ICD-10 Finland
Retinal detachment with retinal break
6.7
16.9
43
67
ZXA00
NOMESCO Finland
Right side
2.0
16.8
261
1527
H16.3
ICD-10 Finland
Interstitial and deep keratitis
+∞
16.7
16
*
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
6.5
16.6
43
69
TCF00
NOMESCO Finland
Subconjunctival therapeutic injection
61.2
15.8
18
*
3718X
ICD-9 Finland
Corneal opacity and other disorders of cornea, Other corneal disorders
+∞
15.7
15
*
H11.0
ICD-10 Finland
Pterygium
13.4
15.3
26
20
S01XA18
ATC
ciclosporin; ophthalmic
45.9
15.1
18
*
CBH30
NOMESCO Finland
Tarsorraphy
+∞
14.6
14
*
J05AB01
ATC
aciclovir; systemic
2.1
14.4
185
994
T15.0
ICD-10 Finland
Foreign body in cornea
4.9
14.1
46
98
CGF35
NOMESCO Finland
Repair of cornea using graft
+∞
13.6
13
*
S01EE01
ATC
latanoprost; ophthalmic
3.3
13.6
71
232
H26.4
ICD-10 Finland
After-cataract
2.7
13.6
100
406
ZXA05
NOMESCO Finland
Left side
1.9
13.2
231
1395
CGF10
NOMESCO Finland
Suture of laceration of cornea
50.8
12.9
15
*
B00.5
ICD-10 Finland
Herpesviral ocular disease
50.8
12.9
15
*
114
Kela drug reimbursment
Glaucoma
2.7
12.8
90
356
S01GX01
ATC
cromoglicic acid; ophthalmic
2.1
12.7
164
879
S01FA04
ATC
cyclopentolate; ophthalmic
15.7
12.7
20
13
S05.6
ICD-10 Finland
Penetrating wound of eyeball without foreign body
131.9
12.5
13
*
S01AA01
ATC
chloramphenicol; ophthalmic (antibiotics)
3.3
12.1
60
189
H02.2
ICD-10 Finland
Lagophthalmos
21.7
12.0
17
8
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
3.2
11.6
60
195
H57.1
ICD-10 Finland
Ocular pain
5.0
11.5
36
74
37100
ICD-8 Finland
Corneal opacity, Cicatrix (nubecula, macula, leucoma) cornea
+∞
11.5
11
*
H18.2
ICD-10 Finland
Other corneal oedema
+∞
11.5
11
*
CBH25
NOMESCO Finland
Tarsorrhaphy
121.6
11.5
12
*
J05AB11
ATC
valaciclovir; oral
2.3
11.4
114
546
XCH00
NOMESCO Finland
Eye pressure measurement
3.9
11.3
46
123
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
7.5
11.0
25
34
H15.1
ICD-10 Finland
Episcleritis
43.9
10.9
13
*
S01AX11
ATC
[U] ofloxacin; ophthalmic
3.7
10.8
46
129
S01BC05
ATC
ketorolac; ophthalmic
3.6
10.3
46
134
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
4.8
10.2
33
71
H01.0
ICD-10 Finland
Blepharitis
3.1
10.2
55
185
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
10.2
222
1425
CKD60
NOMESCO Finland
Anterior vitrectomy
8.6
10.1
21
25
H52.3
ICD-10 Finland
Anisometropia and aniseikonia
11.5
10.1
18
16
W44
ICD-10 Finland
Foreign body entering into or through eye or natural orifice
5.8
9.9
27
48
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
8.9
9.8
20
23
CBG00
NOMESCO Finland
Epilation of cilia by electrolysis
55.6
9.7
11
*
S05.0
ICD-10 Finland
Injury of conjunctiva and corneal abrasion without mention of foreign body
5.5
9.6
27
50
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
30.4
9.4
12
*
H18.9
ICD-10 Finland
Disorder of cornea, unspecified
+∞
9.4
9
*
H18.7
ICD-10 Finland
Other corneal deformities
+∞
9.4
9
*
S05.3
ICD-10 Finland
Ocular laceration without prolapse or loss of intraocular tissue
+∞
9.4
9
*
37404
ICD-8 Finland
Cataract, Secundaria
+∞
9.4
9
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.1
9.0
109
566
S01EA03
ATC
apraclonidine; ophthalmic
8.1
8.9
19
24
H10.4
ICD-10 Finland
Chronic conjunctivitis
10.8
8.8
16
15
L04AA01
ATC
[U] ciclosporin; systemic
5.7
8.8
24
43
H52.1
ICD-10 Finland
Myopia
3.9
8.7
34
89
J01DB01
ATC
cefalexin; oral
1.6
8.6
638
5560
S01FA02
ATC
scopolamine; ophthalmic
11.7
8.6
15
13
XCD10
NOMESCO Finland
Electrophysiological examination of eye
4.3
8.6
30
71
H02.4
ICD-10 Finland
Ptosis of eyelid
4.3
8.6
30
71
WX142
NOMESCO Finland
Sub-tenon anesthesy
16.5
8.6
13
8
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
2.9
8.5
51
185
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
27.8
8.5
11
*
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
27.8
8.5
11
*
H26.1
ICD-10 Finland
Traumatic cataract
20.3
8.5
12
6
H43.1
ICD-10 Finland
Vitreous haemorrhage
4.8
8.5
27
58
H20.8
ICD-10 Finland
Other iridocyclitis
90.9
8.4
9
*
CGG31
NOMESCO Finland
Posterior corneal lamellar transplantation
90.9
8.4
9
*
T86.8
ICD-10 Finland
Failure and rejection of other transplanted organs and tissues
+∞
8.3
8
*
CGW99
NOMESCO Finland
Other operation on cornea or sclera
+∞
8.3
8
*
CGE16
NOMESCO Finland
Destruction of lesion of cornea
+∞
8.3
8
*
37872
ICD-8 Finland
Other diseases of eye, Aphakia artefacta, acquisita
+∞
8.3
8
*
H19.2
ICD-10 Finland
Keratitis and keratoconjunctivitis in other infectious and parasitic diseases classified elsewhere
+∞
8.3
8
*
3700A
ICD-9 Finland
Keratitis, Corneal ulcer
+∞
8.3
8
*
3619
FHL
Other operations in this group, such as corneal refractive surgery
+∞
8.3
8
*
CBG99
NOMESCO Finland
Other operation for trichiasis
+∞
8.3
8
*
H40.0
ICD-10 Finland
Glaucoma suspect
2.4
8.2
66
284
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
4.8
8.2
26
56
H54.4
ICD-10 Finland
Blindness, monocular
33.7
8.1
10
*
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
17.4
8.1
12
7
CGC10
NOMESCO Finland
Removal of foreign body from cornea
10.2
8.0
15
15
CKD20
NOMESCO Finland
Removal of vitreous body substitute
22.3
8.0
11
5
F29
ICPC
Eye symptom/complaint other
2.4
8.0
67
293
S01FA01
ATC
atropine; ophthalmic
13.2
7.9
13
10
S05.2
ICD-10 Finland
Ocular laceration and rupture with prolapse or loss of intraocular tissue
45.4
7.7
9
*
CJF10
NOMESCO Finland
Secondary implantation of artificial lens in posterior chamber
45.4
7.7
9
*
WX110
NOMESCO Finland
Local anesthesy
1.5
7.7
520
4359
C01BD01
ATC
amiodarone; systemic
3.7
7.6
32
90
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
6.8
7.6
18
27
H02.1
ICD-10 Finland
Ectropion of eyelid
6.5
7.4
18
28
3661A
ICD-9 Finland
Cataract, Senile cataract
6.5
7.4
18
28
R3120
NOMESCO Finland
Training in mobility skills
80.8
7.4
8
*
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
80.8
7.4
8
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.3
7.4
68
311
H02AB06
ATC
prednisolone; systemic
1.5
7.4
355
2752
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
7.3
340
2610
H22.0*B00.5
ICD-10 Finland
Herpesviral iridocyclitis
+∞
7.3
7
*
36399
ICD-8 Finland
Keratitis, Without mention of ulcer
+∞
7.3
7
*
CGD99
NOMESCO Finland
Other operation for error of refraction
+∞
7.3
7
*
H21.0
ICD-10 Finland
Hyphaema
+∞
7.3
7
*
37403
ICD-8 Finland
Cataract, Complicata
+∞
7.3
7
*
S01EX03
ATC
NA
4.3
7.3
25
59
H25.0
ICD-10 Finland
Senile incipient cataract
2.4
7.2
59
255
H25.8
ICD-10 Finland
Other senile cataract
2.0
7.2
91
481
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
4.3
7.1
25
60
S01EC03
ATC
dorzolamide; ophthalmic
6.1
7.1
18
30
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
8.9
7.1
14
16
H57.9
ICD-10 Finland
Disorder of eye and adnexa, unspecified
7.1
7.0
16
23
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.7
7.0
157
1006
H43.8
ICD-10 Finland
Other disorders of vitreous body
2.2
6.8
68
326
CKC10
NOMESCO Finland
Local photocoagulation of retina
5.0
6.7
20
41
N02AX02
ATC
tramadol; systemic, rectal
1.5
6.7
322
2483
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
3.0
6.7
36
124
S01EC54
ATC
brinzolamide, combinations; ophthalmic
6.9
6.5
15
22
3793A
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[APHAKIA]
70.4
6.4
7
*
H54.0
ICD-10 Finland
Blindness, binocular
70.4
6.4
7
*
L28
ICPC
Limited function/disability (L)
1.7
6.4
122
746
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
3.5
6.3
27
78
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
3.0
6.3
33
112
CF2S4
NOMESCO Finland
Photography of conjunctiva
18.2
6.3
9
5
37520
ICD-8 Finland
Glaucoma, Secondary
+∞
6.3
6
*
3716A
ICD-9 Finland
Corneal opacity and other disorders of cornea, Keratoconus
+∞
6.3
6
*
H15.0
ICD-10 Finland
Scleritis
+∞
6.3
6
*
3651
FHL
Penetrating corneal transplantation and cataract surgery
+∞
6.3
6
*
CHB15
NOMESCO Finland
Puncture of anterior chamber of eye with replacement of aqueous
+∞
6.3
6
*
05405
ICD-8 Finland
Herpes simplex, Kerato-conjunctivitis herpetica
+∞
6.3
6
*
S05.1
ICD-10 Finland
Contusion of eyeball and orbital tissues
4.8
6.3
19
40
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
6.3
6.2
15
24
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
4.7
6.1
19
41
S01AA12
ATC
tobramycin; ophthalmic
10.1
6.0
11
11
127
Kela drug reimbursment
Transplant complication
4.2
6.0
21
51
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
3.3
6.0
28
87
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
3.7
6.0
24
66
A02BC02
ATC
pantoprazole; systemic
1.4
6.0
492
4181

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
237
898
3.19
47.45
2.0
1.7
—
—
—
0
0
18
17
10.77
16.47
1.4
1.5
—
—
—
0
0
506
3757
1.75
15.54
6.9
5.7
0.6
0.6
e9/l
2.02
437
3231
519
3893
1.74
15.26
7.4
6.0
0.2
0.2
e9/l
0.27
460
3421
371
2535
1.76
15.19
7.4
5.8
—
—
—
0
0
506
3773
1.73
15.17
7.0
5.7
0.0
0.0
e9/l
0.17
440
3255
483
3558
1.73
15.10
7.5
6.1
9.0
8.7
%
0.97
452
3328
489
3647
1.71
14.34
7.4
5.9
27.2
27.6
%
0.30
455
3394
467
3446
1.70
14.20
7.4
5.9
0.6
0.7
%
0.41
434
3210
510
3855
1.70
14.16
7.1
5.7
1.8
1.9
e9/l
0.76
454
3392
482
3592
1.70
14.09
7.0
5.8
57.8
57.4
%
0.29
447
3361
476
3541
1.69
13.96
7.2
5.9
2.9
2.9
%
0.12
443
3297
194
1127
1.91
13.26
2.4
2.1
—
—
—
0
0
209
1244
1.87
13.25
4.3
3.3
0.8
0.8
mmol/l
0.41
191
1166
499
3794
1.67
13.18
9.2
6.9
1.2
1.2
mmol/l
0.45
423
3184
446
3300
1.67
13.05
6.6
4.8
34.5
35.4
g/l
2.43
414
3066
330
2257
1.71
13.00
5.8
4.0
7.4
7.4
ph
0.95
52
438
235
1459
1.81
12.98
4.7
3.8
184.8
307.4
ng/l
0.68
181
1146
640
5259
1.67
11.92
5.3
4.3
—
—
—
0
0
413
3052
1.63
11.76
2.7
2.2
77.1
77.2
nmol/l
0.02
371
2706
309
2136
1.66
11.39
5.7
4.3
—
—
—
0
0
553
4409
1.61
11.36
10.4
9.0
4.2
4.1
e9/l
0.28
486
3844
689
5863
1.64
10.26
9.3
7.6
83.1
79.4
u/l
0.65
655
5491
166
1001
1.80
9.87
10.6
5.6
1.1
1.0
mmol/l
1.19
154
922
193
1222
1.73
9.68
4.0
2.4
12.5
12.9
umol/l
0.40
174
1128
502
4005
1.54
9.57
6.7
6.5
12.4
11.6
umol/l
0.37
474
3798
110
586
1.99
9.55
5.4
3.6
114.6
83.0
ng/l
1.92
98
507
414
3169
1.54
9.52
12.5
9.4
1.3
1.3
inr
0.02
117
919
662
5623
1.59
9.48
5.1
4.0
14.0
12.4
mm/h
1.76
622
5178
446
3473
1.54
9.47
8.0
6.1
1.2
1.2
mmol/l
0.73
407
3131
407
3118
1.54
9.25
2.1
2.0
97.2
95.1
pmol/l
0.34
207
1600
148
879
1.81
9.22
2.4
2.7
1.9
1.8
%
0.24
123
789
276
1938
1.60
9.21
2.6
2.2
2.9
3.1
mg/l
0.38
231
1642
275
1938
1.59
9.00
4.7
3.9
87.3
89.7
%
0.72
266
1902
272
1916
1.59
8.91
6.9
6.6
—
—
—
0
0
838
7616
1.88
8.77
21.8
14.4
25.1
24.4
mg/l
0.26
678
6020
247
1706
1.61
8.76
3.8
3.7
—
—
—
0
0
361
2721
1.53
8.70
4.6
3.7
104.3
126.8
e6/l
0.23
261
1950
601
5045
1.52
8.63
5.3
4.5
2470.0
2911.1
e6/l
—
7
76
670
5761
1.56
8.59
4.3
3.9
14.8
14.8
pmol/l
0.02
601
5204
429
3368
1.50
8.44
11.4
9.5
0.0
0.0
e9/l
0.04
342
2754
176
1130
1.68
8.29
4.1
2.3
2.2
2.3
g/l
1.08
159
1046
216
1462
1.62
8.28
1.9
1.8
1111.4
1183.1
nmol/l
0.60
169
1081
165
1065
1.67
7.58
4.3
2.4
21.8
22.8
%
0.45
141
906
851
7850
1.84
7.38
24.6
16.9
139.5
139.6
mmol/l
0.87
833
7630
541
4528
1.45
7.26
5.9
4.9
6.8
6.7
mmol/l
0.45
503
4243
851
7868
1.81
7.06
25.2
17.0
4.0
4.0
mmol/l
1.13
832
7635
308
2324
1.48
7.06
2.5
2.1
222.3
269.4
u/l
0.36
290
2198
775
6997
1.60
7.01
6.5
5.8
40.3
40.0
mmol/mol
0.28
714
6461
869
8100
1.89
6.82
13.2
10.4
25.9
26.6
u/l
0.47
841
7803
111
665
1.76
6.67
2.6
2.8
68.6
70.6
e9/l
0.23
81
521
769
6953
1.57
6.66
5.3
4.6
2.0
2.1
mu/l
0.35
694
6314
279
2085
1.48
6.64
4.0
3.0
—
—
—
0
0
286
2154
1.47
6.53
4.1
3.1
0.4
0.5
e6/l
0.23
221
1630
108
648
1.75
6.45
8.9
8.5
—
—
—
0
0
11
18
6.17
6.44
5.1
3.9
—
—
—
0
0
150
992
1.61
6.20
1.5
1.3
845.5
469.6
titre
0.71
29
207
402
3248
1.41
6.19
4.0
2.7
136.2
136.2
ug/l
0.00
364
2969
305
2351
1.44
6.09
4.3
3.2
73.5
91.1
e6/l
0.15
242
1813
333
2614
1.42
5.99
3.8
3.5
2.3
2.4
mmol/l
0.44
294
2267
117
734
1.68
5.95
6.9
4.0
1.9
2.0
mmol/l
0.18
97
587
308
2395
1.42
5.81
3.6
2.6
59.7
57.2
u/l
0.29
288
2223
615
5392
1.40
5.63
4.5
3.9
—
—
—
0
0
301
2342
1.42
5.62
3.4
3.1
—
—
—
0
0
104
643
1.69
5.59
4.4
3.0
333.5
198.0
ng/l
0.87
98
585
703
6319
1.44
5.52
26.1
17.5
13.8
13.7
%
0.76
685
6189
115
741
1.63
5.28
7.0
3.9
6.0
5.8
kpa
1.46
109
720
63
345
1.89
5.09
1.9
2.0
1.5
1.6
g/l
0.13
54
304
20
65
3.12
5.09
1.1
1.2
—
—
—
0
0
757
6938
1.46
5.02
23.1
15.5
39.0
39.9
%
1.58
540
4881
172
1233
1.48
4.90
3.0
2.9
1.3
2.3
e6/l
1.99
97
678
362
2959
1.36
4.88
2.2
2.1
—
—
—
0
0
66
373
1.83
4.85
6.9
4.5
24.4
24.2
mmol/l
0.15
60
335
890
8475
1.85
4.83
30.9
21.2
246.8
247.4
e9/l
0.10
870
8246
890
8477
1.84
4.80
30.9
21.1
91.4
91.1
fl
1.07
876
8336
890
8478
1.84
4.78
30.8
21.1
30.4
30.3
pg
0.23
876
8335
174
1256
1.47
4.78
2.1
1.8
—
—
—
0
0
890
8479
1.84
4.77
30.9
21.2
4.4
4.5
e12/l
4.95
864
8220
890
8480
1.84
4.75
31.0
21.2
7.1
6.7
e9/l
0.64
864
8222
890
8482
1.83
4.72
31.2
21.3
133.4
135.5
g/l
3.62
879
8341
78
468
1.73
4.69
3.7
2.9
—
—
—
0
0
440
3725
1.34
4.64
5.8
4.9
0.0
0.0
estimate
0.50
69
720
195
1448
1.44
4.61
1.5
1.4
2.5
2.5
g/l
0.02
124
885
794
7376
1.48
4.60
4.9
4.6
6.0
6.0
mmol/l
0.13
718
6676
444
3769
1.34
4.58
4.3
3.7
0.0
0.0
estimate
0.50
65
701
10
21
4.80
4.54
1.8
1.7
—
—
—
0
0
97
623
1.62
4.52
1.6
3.0
66.5
66.5
g/l
0.01
86
567
120
812
1.55
4.48
2.0
1.6
—
—
—
0
0
12
30
4.04
4.44
1.1
1.2
—
—
—
0
0
127
872
1.53
4.44
2.7
2.8
10.0
9.0
umol/l
0.14
112
761
701
6385
1.38
4.42
27.6
18.6
331.8
332.6
g/l
1.54
695
6333
287
2293
1.36
4.39
3.7
3.1
1598.3
1357.1
ng/l
0.50
251
1948
84
525
1.66
4.36
1.5
1.4
—
—
—
0
0
251
1965
1.38
4.36
3.1
2.7
354.5
7577.4
umol/l
8.17
221
1696
121
828
1.53
4.30
1.3
1.3
—
—
—
0
0
214
1637
1.40
4.26
4.0
2.6
4.6
5.7
e6/l
0.53
191
1446
140
990
1.49
4.25
26.4
25.2
1.3
1.3
inr
0.05
19
127
435
3712
1.32
4.21
4.2
3.7
0.0
0.0
estimate
0.00
65
713
219
1687
1.39
4.17
1.8
1.7
1.1
1.2
mg/l
0.37
165
1289
841
7948
1.52
4.03
20.0
13.7
—
—
—
0
0
131
925
1.48
4.01
1.9
1.4
—
—
—
0
0
813
7638
1.46
3.95
5.3
4.9
2.6
2.7
mmol/l
1.94
742
6992
214
1658
1.38
3.92
1.4
1.2
2.0
1.5
u/ml
0.19
53
455
47
256
1.88
3.92
1.4
1.2
1.3
1.9
u/ml
—
5
15
38
194
2.00
3.82
1.1
1.1
—
—
—
0
0
43
230
1.91
3.79
1.7
2.7
37.4
37.2
g/l
0.07
37
196
109
750
1.51
3.78
2.6
2.3
0.2
0.2
g/l
0.11
103
708
102
692
1.53
3.78
3.0
2.3
37.6
34.8
u/l
0.27
85
590
300
2459
1.32
3.77
2.7
2.5
—
—
—
0
0
356
2989
1.31
3.76
4.2
3.7
40.5
50.3
ng/l
0.32
261
2119
142
1032
1.44
3.75
2.0
1.6
—
—
—
0
0
32
155
2.10
3.70
1.8
2.1
—
—
—
0
0
29
135
2.18
3.70
1.5
1.6
—
—
—
0
0
138
1003
1.44
3.64
5.9
7.0
104.3
104.1
mmol/l
0.21
133
977
33
163
2.06
3.64
2.0
2.2
131.1
130.0
g/l
0.08
25
121
417
3589
1.29
3.61
4.8
4.1
—
—
—
0
0
80
521
1.58
3.56
1.7
2.6
—
—
—
0
0
235
1876
1.34
3.52
2.7
2.4
—
—
—
0
0
93
631
1.53
3.46
4.8
3.3
4.7
4.5
kpa
0.51
87
611
122
877
1.45
3.42
2.1
2.4
117.0
125.0
ug/g
0.13
97
707
160
1209
1.39
3.39
2.6
2.1
29.3
29.7
s
0.31
155
1174
61
376
1.67
3.38
3.1
3.6
—
—
—
0
0
231
1849
1.33
3.38
1.7
1.5
20.0
20.7
nmol/l
0.27
199
1557
186
1443
1.36
3.35
2.9
3.0
2.5
2.4
mmol/l
0.32
164
1270
12
37
3.27
3.35
1.7
3.0
698.7
1510.7
u/ml
0.65
12
37
768
7210
1.35
3.18
4.2
3.9
1.3
1.3
mmol/l
0.50
696
6569
795
7506
1.37
3.15
4.8
4.4
4.5
4.6
mmol/l
2.21
733
6920
26
125
2.11
3.10
7.2
2.8
—
—
—
0
0
790
7460
1.36
3.05
4.6
4.4
1.4
1.5
mmol/l
2.18
719
6834
10
29
3.47
3.05
1.5
1.6
—
—
—
0
0
98
691
1.47
3.05
2.5
2.4
4.6
7.3
ug/l
1.95
83
606
18
75
2.43
2.98
1.2
1.3
—
—
—
0
0
138
1044
1.38
2.91
1.2
1.2
—
—
—
0
0
63
410
1.57
2.85
4.3
3.4
4.5
4.6
pmol/l
0.22
56
360
17
71
2.42
2.81
1.0
1.1
—
—
—
0
0
50
312
1.64
2.69
1.7
1.8
—
—
—
0
0
18
80
2.27
2.62
2.3
2.5
—
—
—
0
0
68
461
1.51
2.59
1.8
1.6
2.0
1.5
g/l
0.58
63
426
9
25
3.62
2.58
1.0
1.2
—
—
—
0
0
38
223
1.73
2.57
3.4
3.4
—
—
—
0
0
5
7
7.17
2.55
16.0
5.3
4.1
7.4
mmol/l
—
5
7
9
26
3.48
2.48
1.0
1.0
—
—
—
0
0
27
144
1.90
2.48
3.9
3.5
58.0
59.0
%
0.13
27
144
78
550
1.46
2.46
1.2
1.2
—
—
—
0
0
118
896
1.36
2.44
7.1
7.6
1.8
1.3
mmol/l
0.78
97
698
268
2272
1.25
2.43
4.0
3.2
597.8
281.8
mg/l
0.41
170
1447
125
959
1.35
2.42
1.2
1.3
—
—
—
0
0
202
1659
1.28
2.39
1.8
1.7
142353371.7
15646183.1
pmol/l
0.88
170
1355
27
146
1.87
2.39
2.3
1.5
—
—
—
0
0
26
139
1.90
2.38
3.4
3.2
3.7
4.5
e9/l
1.25
26
139
44
679
0.63
2.35
1.4
1.4
—
—
—
0
0
60
406
1.51
2.33
1.3
1.2
—
—
—
0
0
52
341
1.56
2.32
1.1
1.1
—
95.9
—
0
7
17
78
2.20
2.32
1.5
1.3
—
—
—
0
0
117
896
1.35
2.30
7.2
7.5
5.3
5.1
kpa
1.32
111
858
117
897
1.35
2.29
7.2
7.5
12.1
12.2
kpa
0.05
111
862
17
79
2.17
2.25
1.3
1.3
12323.0
51895.8
e6/l
—
10
45
16
73
2.21
2.22
2.6
1.7
—
—
—
0
0
188
1548
1.27
2.18
3.9
2.7
536.3
558.2
mosm/kgh2o
0.71
163
1332
282
2431
1.23
2.17
4.7
3.1
7.1
7.7
mmol/l
1.18
246
2026
6
14
4.31
2.15
1.7
1.4
—
—
—
0
0
14
61
2.31
2.15
3.6
1.8
1.3
1.1
e9/l
—
6
35
9
30
3.02
2.15
1.0
1.1
1197.1
189.1
iu/ml
—
9
30
18
88
2.07
2.12
1.3
1.3
1523.8
1834.0
e6/l
0.13
13
59
38
238
1.62
2.07
1.6
3.8
31.5
44.1
mg/l
0.48
29
196
57
392
1.48
2.07
2.6
2.4
—
—
—
0
0
13
56
2.34
2.05
1.5
1.2
—
—
—
0
0
200
1675
1.25
2.00
4.4
4.4
—
—
—
0
0
6
16
3.77
1.93
1.2
1.1
—
—
—
0
0
36
227
1.61
1.93
1.5
1.5
201.9
287.8
ug/g
1.98
19
140
61
432
1.44
1.93
1.5
1.2
317.9
193.1
u/ml
0.54
56
392
27
158
1.73
1.90
2.4
2.4
16.4
16.3
%
0.03
18
83
49
335
1.49
1.86
2.1
1.9
2.3
2.3
ug/l
0.01
42
297
37
238
1.58
1.84
1.6
3.8
47.1
79.2
mg/l
0.63
28
195
8
29
2.77
1.79
2.6
1.9
57.5
65.4
mg/l
—
8
23
68
499
1.39
1.78
7.8
6.6
26.0
24.4
mmol/l
2.27
61
467
33
209
1.60
1.76
1.3
1.1
—
—
—
0
0
17
88
1.95
1.75
3.2
8.9
7.6
7.1
mmol/l
0.19
12
72
56
401
1.42
1.69
6.7
10.4
24.9
24.6
mmol/l
0.35
48
376
274
2407
1.19
1.69
4.9
4.0
16.5
8.2
mg/mmol
1.59
181
1529
17
90
1.91
1.66
1.4
1.2
—
75.1
—
0
5
20
112
1.80
1.65
2.4
1.8
0.6
0.9
g/l
0.92
14
86
14
69
2.04
1.65
1.2
1.4
—
—
—
0
0
87
673
1.32
1.65
1.6
1.4
—
—
—
0
0
25
150
1.68
1.64
2.3
2.5
—
—
—
0
0
260
2280
1.19
1.63
4.6
3.9
—
—
—
0
0
194
1656
1.22
1.62
4.3
4.0
1.0
1.0
kg/l
0.15
30
235
17
91
1.88
1.61
1.2
1.6
—
—
—
0
0
17
91
1.88
1.61
1.2
1.6
—
—
—
0
0
17
91
1.88
1.61
1.2
1.6
—
—
—
0
0
17
91
1.88
1.61
1.2
1.6
—
—
—
0
0
13
63
2.08
1.60
1.2
1.1
—
—
—
0
0
13
64
2.05
1.54
2.7
6.5
10.8
10.8
%
0.01
13
64
14
71
1.99
1.54
1.4
1.7
—
—
—
0
0
67
504
1.35
1.54
2.9
3.0
4.4
4.0
e9/l
0.71
48
389
8
33
2.44
1.54
1.0
1.1
—
—
—
0
0
32
209
1.55
1.53
3.0
2.3
272.2
89.8
ug/min
0.99
22
127
11
51
2.17
1.51
3.5
1.9
645.0
782.7
e6/l
—
6
19
36
243
1.50
1.49
1.1
1.1
—
—
—
0
0
24
147
1.65
1.48
2.0
1.3
111.2
109.4
u/ml
—
6
27
148
1241
1.23
1.48
1.3
1.3
28.4
34.0
iu/ml
0.31
51
387
10
45
2.24
1.46
1.5
1.3
—
—
—
0
0
7
28
2.51
1.45
1.0
1.0
—
—
—
0
0
6
22
2.74
1.43
3.3
2.0
—
—
—
0
0
26
165
1.59
1.41
2.5
4.4
—
—
—
0
0
18
104
1.74
1.37
3.3
2.5
—
—
—
0
0
6
23
2.62
1.37
3.2
3.3
—
—
—
0
0
14
75
1.88
1.35
3.1
2.3
—
—
—
0
0
25
160
1.58
1.32
2.2
1.4
—
—
—
0
0
35
242
1.46
1.32
1.5
1.2
—
—
—
0
0
295
2658
1.16
1.31
5.1
4.9
2.0
2.8
ug/l
1.37
268
2376
55
413
1.35
1.31
10.9
10.2
—
—
—
0
0
29
193
1.52
1.30
1.9
1.7
33184.8
16640.1
e6/l
0.49
23
141
26
169
1.55
1.30
1.3
1.7
—
—
—
0
0
242
2709
0.86
1.29
3.2
2.8
—
—
—
0
0
68
529
1.31
1.28
5.3
3.6
5.2
5.1
kpa
0.26
59
496
8
35
2.30
1.27
4.5
1.7
0.2
0.2
e9/l
—
8
35
14
77
1.83
1.26
2.9
1.9
—
—
—
0
0
140
1191
1.21
1.23
1.3
1.3
27.0
13.3
u/ml
0.53
38
434
92
749
1.25
1.22
5.7
4.4
—
—
—
0
0
67
524
1.30
1.22
5.4
3.6
7.4
7.4
ph
0.28
13
64
74
587
1.28
1.22
3.5
4.2
2.6
0.5
%
—
9
151
80
643
1.27
1.19
3.6
4.3
2.0
1.0
%
0.39
14
202
6
26
2.32
1.19
1.0
1.3
—
—
—
0
0
17
102
1.68
1.16
4.4
2.7
—
—
—
0
0
27
183
1.49
1.14
1.8
1.9
2.7
5.9
iu/l
—
8
60
25
167
1.51
1.13
1.8
1.4
3.8
3.8
mmol/l
0.14
25
156
25
167
1.51
1.13
2.1
1.5
42.7
7.8
e6/l
0.58
20
129
8
40
2.01
1.12
1.0
1.6
1.2
1.2
nmol/l
—
8
29
5
21
2.39
1.09
1.6
1.6
—
—
—
0
0
5
21
2.39
1.09
2.0
1.4
—
—
—
0
0
24
161
1.50
1.07
7.2
4.6
2.1
2.5
mmol/l
0.48
16
108
75
607
1.26
1.07
3.6
4.4
0.2
0.1
%
0.28
14
183
6
125
0.48
1.05
1.3
1.4
—
—
—
0
0
6
125
0.48
1.05
1.3
1.4
—
—
—
0
0
21
138
1.53
1.03
1.5
1.2
—
—
—
0
0
9
49
1.84
0.98
2.8
2.6
—
—
—
0
0
28
198
1.43
0.98
6.9
4.3
7.4
7.4
ph
1.19
22
158
5
23
2.18
0.98
1.0
1.0
1155.6
1624.4
miu/ml
—
5
23
43
328
1.33
0.97
6.7
4.3
24.6
24.9
mmol/l
0.28
36
310
25
174
1.45
0.96
1.3
4.0
—
—
—
0
0
19
125
1.53
0.94
1.5
1.5
—
—
—
0
0
43
331
1.31
0.92
1.7
1.2
—
—
—
0
0
9
52
1.74
0.92
1.1
1.0
37.2
43.5
mg/l
—
9
44
9
52
1.74
0.92
1.4
1.1
—
—
—
0
0
7
129
0.54
0.88
1.6
1.5
—
—
—
0
0
42
325
1.31
0.88
2.2
2.7
—
—
—
0
0
23
161
1.44
0.87
6.5
3.6
—
—
—
0
0
11
64
1.73
0.86
1.4
1.3
—
—
—
0
0
8
44
1.83
0.86
1.6
1.5
—
59.3
—
0
11
222
2021
1.13
0.84
1.8
1.7
1.3
1.4
mmol/l
0.77
194
1687
8
46
1.75
0.82
8.9
20.1
1137.4
1476.1
nmol/l
—
8
46
17
113
1.51
0.82
1.2
1.1
—
—
—
0
0
6
32
1.88
0.82
7.3
3.0
—
—
—
0
0
12
73
1.65
0.82
2.3
4.1
—
—
—
0
0
29
215
1.36
0.81
1.6
1.8
42.5
39.2
nmol/l
0.48
29
206
64
529
1.23
0.80
5.5
4.5
—
—
—
0
0
17
114
1.50
0.80
1.2
1.1
—
—
—
0
0
6
34
1.77
0.76
1.0
1.3
137.7
142.9
nmol/l
—
6
34
10
60
1.67
0.72
1.4
1.6
1.4
1.1
promille
—
10
45
32
247
1.31
0.71
1.6
1.6
—
—
—
0
0
9
57
1.58
0.71
4.7
2.2
—
—
—
0
0
36
283
1.28
0.70
4.9
3.4
0.3
0.3
g/l
0.21
18
127
7
41
1.71
0.70
1.0
1.0
—
—
—
0
0
7
41
1.71
0.70
1.0
1.2
—
—
—
0
0
7
41
1.71
0.70
1.0
1.1
—
—
—
0
0
13
85
1.54
0.69
1.3
1.2
—
—
nmol/l
—
0
0
7
43
1.63
0.67
1.0
1.0
—
—
—
0
0
5
28
1.79
0.66
6.4
3.3
—
—
—
0
0
70
598
1.18
0.65
2.8
2.2
12.9
13.3
nmol/l
0.19
65
539
21
154
1.37
0.65
3.9
4.1
19.5
26.8
mg/l
0.68
15
99
58
489
1.20
0.63
1.3
1.2
106.3
134.8
iu/ml
0.27
21
197
47
388
1.22
0.63
6.7
3.8
—
—
—
0
0
27
208
1.31
0.62
4.1
4.5
—
—
—
0
0
17
121
1.41
0.62
1.6
1.4
—
—
—
0
0
17
121
1.41
0.62
2.5
2.7
61.3
40.4
u/ml
0.12
17
114
17
121
1.41
0.62
1.1
1.1
164.3
90.5
iu/ml
—
5
25
14
96
1.47
0.61
1.3
1.2
0.6
0.6
nmol/l
0.01
14
89
5
30
1.67
0.61
4.6
1.3
—
—
—
0
0
8
50
1.61
0.61
1.1
1.0
237.3
253.1
mg/l
—
8
45
74
640
1.17
0.61
6.4
3.7
1.2
1.2
mmol/l
0.39
62
553
0
22
0.00
0.59
0.0
1.1
—
0.7
—
0
13
8
53
1.51
0.58
2.4
4.2
—
—
—
0
0
0
23
0.00
0.58
0.0
1.4
—
15.9
—
0
18
18
132
1.37
0.57
1.3
1.4
—
—
—
0
0
16
115
1.40
0.57
1.1
1.3
—
—
—
0
0
6
37
1.63
0.55
2.8
7.1
—
—
—
0
0
13
90
1.45
0.55
1.3
1.2
—
—
—
0
0
6
38
1.58
0.54
1.3
1.9
—
—
—
0
0
12
83
1.45
0.52
1.3
1.4
—
—
—
0
0
6
40
1.50
0.51
1.3
1.3
—
—
—
0
0
6
41
1.47
0.50
3.0
3.8
—
—
—
0
0
7
45
1.56
0.49
2.3
3.6
—
—
—
0
0
20
154
1.31
0.48
1.2
1.2
—
—
—
0
0
7
46
1.53
0.48
3.6
1.6
—
48.6
—
0
5
53
458
1.17
0.47
1.2
1.2
—
—
—
0
0
65
572
1.15
0.46
3.5
4.4
0.0
0.7
%
—
8
159
7
49
1.43
0.46
1.1
1.6
—
—
—
0
0
71
632
1.13
0.43
5.0
3.5
—
—
—
0
0
12
87
1.38
0.42
1.5
1.4
—
—
—
0
0
10
70
1.43
0.42
1.3
1.4
—
—
—
0
0
29
240
1.21
0.41
1.2
1.1
—
—
—
0
0
5
34
1.47
0.40
1.4
1.4
—
—
—
0
0
8
60
1.34
0.40
1.5
1.6
0.9
1.0
g/l
—
8
60
68
608
1.13
0.39
2.0
1.6
—
—
—
0
0
10
71
1.41
0.39
1.1
1.1
4.4
4.5
u/ml
—
5
27
215
2035
1.07
0.39
5.1
4.0
0.0
0.0
estimate
0.88
67
692
12
159
0.75
0.38
1.3
1.2
—
—
—
0
0
26
312
0.83
0.38
1.0
1.1
—
—
—
0
0
12
89
1.35
0.38
1.3
1.2
—
—
—
0
0
9
68
1.33
0.37
1.1
1.0
—
—
—
0
0
13
98
1.33
0.37
1.0
1.1
0.7
0.9
u/ml
—
7
41
6
42
1.43
0.35
1.3
1.8
1.7
2.5
u/field
—
6
29
164
1546
1.07
0.34
3.2
3.0
0.7
0.8
ug/l
1.22
120
1009
24
200
1.21
0.34
1.1
1.3
127.4
249.9
miu/ml
—
7
94
15
119
1.26
0.32
3.1
2.6
—
—
—
0
0
16
129
1.24
0.30
1.3
1.7
—
—
—
0
0
15
120
1.25
0.30
2.0
1.2
6.1
4.3
u/ml
—
9
46
77
710
1.09
0.28
1.6
1.5
—
—
—
0
0
8
63
1.27
0.27
1.5
1.4
—
—
—
0
0
26
225
1.16
0.26
1.1
1.2
—
656.0
—
0
5
9
72
1.25
0.25
1.0
1.2
—
—
—
0
0
198
2063
0.95
0.25
4.4
3.2
—
—
—
0
0
21
245
0.85
0.25
2.8
2.0
—
—
—
0
0
14
114
1.23
0.25
1.1
1.2
—
—
—
0
0
14
115
1.22
0.23
1.1
1.1
1.8
3.4
u/ml
—
7
45
23
264
0.87
0.23
2.7
1.9
—
—
—
0
0
13
106
1.23
0.23
1.1
1.1
5.8
6.1
u/ml
—
7
54
214
2064
1.05
0.22
1.4
1.4
—
—
—
0
0
23
263
0.87
0.22
2.7
1.9
—
—
—
0
0
23
263
0.87
0.22
2.7
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
4.0
—
0
6
0
13
0.00
0.21
0.0
1.2
—
1.8
—
0
13
0
13
0.00
0.21
0.0
3.2
—
—
—
0
0
13
108
1.21
0.20
1.5
2.0
34.4
32.8
pg
0.84
13
108
6
50
1.20
0.19
1.2
1.0
—
—
—
0
0
12
99
1.21
0.19
1.1
1.2
—
—
—
0
0
12
100
1.20
0.18
1.1
1.1
—
—
—
0
0
63
671
0.93
0.18
6.6
3.7
—
—
—
0
0
36
329
1.10
0.18
4.8
4.3
—
—
—
0
0
60
562
1.07
0.17
1.4
1.4
—
—
—
0
0
5
66
0.76
0.17
1.0
1.5
—
—
—
0
0
8
70
1.14
0.16
1.3
1.2
—
—
—
0
0
18
159
1.13
0.15
1.3
1.8
198.1
228.5
pmol/l
0.61
18
148
26
236
1.10
0.15
1.8
1.6
280.2
301.5
mu/l
0.21
26
213
18
160
1.13
0.14
2.6
1.7
—
—
—
0
0
11
128
0.86
0.13
1.0
1.1
—
12.8
—
0
9
24
262
0.91
0.12
2.6
1.8
—
—
—
0
0
14
123
1.14
0.12
1.0
1.1
—
—
—
0
0
10
85
1.18
0.12
1.3
1.6
—
—
—
0
0
19
208
0.91
0.10
3.0
1.9
—
—
—
0
0
11
96
1.15
0.10
4.0
4.2
—
—
—
0
0
32
340
0.94
0.09
1.6
1.7
—
—
—
0
0
5
65
0.77
0.08
2.6
1.9
6.9
6.7
mmol/l
—
5
43
7
68
1.03
0.08
1.1
1.1
—
—
—
0
0
10
112
0.89
0.07
1.2
1.1
1.5
1.5
g/l
—
10
103
12
109
1.10
0.06
1.3
1.2
—
—
—
0
0
17
182
0.93
0.05
1.4
1.2
—
—
—
0
0
45
437
1.03
0.04
1.7
1.4
—
—
—
0
0
20
190
1.05
0.04
3.3
2.2
9480.4
3164.5
u/l
—
8
75
22
230
0.96
0.03
13.5
10.9
—
—
—
0
0
63
640
0.98
0.02
1.3
1.4
—
—
—
0
0
12
126
0.95
0.00
1.3
1.1
—
—
—
0
0
18
174
1.04
0.00
2.1
2.9
—
—
—
0
0
80
802
1.00
0.00
1.5
1.7
—
—
—
0
0
12
117
1.03
0.00
3.1
3.6
1.6
0.9
%
—
5
96
12
119
1.01
0.00
2.9
2.9
—
—
—
0
0
83
825
1.01
0.00
4.3
4.3
27.5
28.7
ug/l
0.02
71
695
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
4.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
8
79
1.01
0.00
1.3
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
6
65
0.92
0.00
1.2
1.0
302.0
286.6
mg/l
—
6
57
0
8
0.00
0.00
0.0
1.0
—
18.2
—
0
8
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
8
86
0.93
0.00
2.0
2.5
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
178.8
—
0
6
7
79
0.89
0.00
2.9
3.3
7.9
15.6
mg/l
—
7
61
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
7
77
0.91
0.00
1.4
2.2
—
—
—
0
0
7
71
0.99
0.00
1.1
2.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H7_CORNEALSCAR and mortality.

Females

Parameter HR [95% CI] p-value
H7_CORNEALSCAR 1.124 [0.99, 1.28] 0.082
Birth year 0.992 [0.98, 1.0] 0.07

During the follow-up period (1.1.1998 — 31.12.2019), 740 out of 2917 females with H7_CORNEALSCAR died.

Males

Parameter HR [95% CI] p-value
H7_CORNEALSCAR 1.186 [1.02, 1.38] 0.028
Birth year 0.987 [0.98, 1.0] 0.008

During the follow-up period (1.1.1998 — 31.12.2019), 559 out of 2918 males with H7_CORNEALSCAR died.

Mortality risk

Mortality risk for people of age

years, who have H7_CORNEALSCAR.

N-year risk Females Males
1 0.082% 0.264%
5 0.564% 1.544%
10 1.441% 3.449%
15 2.847% 6.67%
20 5.252% 10.94%

Relationships between endpoints

Index endpoint: H7_CORNEALSCAR – Corneal scars and opacities

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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