cholesteatoma of middle ear: A non-neoplastic lesion characterized by the proliferation of keratinizing squamous epithelium in the middle ear that results in the accumulation of keratin and cells. It is usually caused by repeated infections. If left untreated, it may increase in size and destroy the adjacent delicate bones of the middle ear.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1998 |
4. Check minimum number of eventsNone |
1998 |
5. Include endpointsNone |
1998 |
6. Filter based on genotype QC (FinnGen only) |
1998 |
Control definitions (FinnGen only)
- Control exclude
- H8_MIDDLEMASTOID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H65-H75
- Name in latin
- Cholesteatoma auris mediae
Similar endpoints
↥List of similar endpoints to
Cholesteatoma of middle ear
based on the number of shared cases.
Similar with more cases:
- Diseases of middle ear and mastoid
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 17391 | 7390 | 9876 |
| Only index persons | 15196 | 6641 | 8555 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.25 | 0.21 | 0.28 |
| Only index persons | 0.29 | 0.24 | 0.33 |
| Median age at first event (years) | |||
| Whole population | 46.07 | 49.35 | 43.53 |
| Only index persons | 44.52 | 48.24 | 41.62 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1998 | 885 | 1113 |
| Unadjusted period prevalence (%) | 0.41 | 0.30 | 0.49 |
| Median age at first event (years) | 48.36 | 46.23 | 50.05 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1791
- Matched controls
- 17911
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
3853A
ICD-9 Finland
Other disorders of middle ear and mastoid, Cholesteatoma of middle ear and mastoid
+∞
323.0
319
*
H71
ICD-10 Finland
Cholesteatoma of middle ear
4503599627370496.0
323.0
1432
*
UDC00
NOMESCO Finland
Ear microscopy
16.0
323.0
592
536
38700
ICD-8 Finland
Other disease of ear and mastoid process, Cholesteatoma of ear
+∞
323.0
414
*
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
620.7
275.3
266
5
DC1AD
NOMESCO Finland
Temporalbone CT
116.9
258.8
277
28
H65.3
ICD-10 Finland
Chronic mucoid otitis media
558.2
250.2
243
5
DFF00
NOMESCO Finland
Pure tone audiometry
8.8
215.9
518
795
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
29.9
208.0
284
112
Z01.1
ICD-10 Finland
Examination of ears and hearing
6.5
198.5
604
1294
DEB25
NOMESCO Finland
Attico-antro-mastoidectomy and tympanoplasty
+∞
196.5
185
*
DCD10
NOMESCO Finland
Tympanoplasty
2112.2
188.9
180
*
DEA10
NOMESCO Finland
Attico-antrotomy
+∞
176.0
166
*
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
+∞
171.7
162
*
H70.1
ICD-10 Finland
Chronic mastoiditis
+∞
166.3
157
*
DEB30
NOMESCO Finland
Radical mastoidectomy
1656.5
155.5
149
*
H66.0
ICD-10 Finland
Acute suppurative otitis media
13.8
154.6
278
235
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
216.3
154.6
158
8
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
242.1
152.7
155
7
DCD00
NOMESCO Finland
Myringoplasty
1545.2
146.9
141
*
4147
FHL
Radical surgery, cavity filling and middle ear and / or eardrum plastic
+∞
131.9
125
*
H74.1
ICD-10 Finland
Adhesive middle ear disease
+∞
127.6
121
*
38210
ICD-8 Finland
Chronic otitis media with mastoiditis
+∞
125.5
119
*
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
28.0
120.0
166
65
H66.9
ICD-10 Finland
Otitis media, unspecified
11.0
116.4
233
241
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
305.6
113.4
114
*
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
3.7
105.9
564
1961
DEB20
NOMESCO Finland
Attico-antro-mastoidectomy and tympanotomy
+∞
105.2
100
*
H65.2
ICD-10 Finland
Chronic serous otitis media
227.3
104.8
107
5
3821A
ICD-9 Finland
Suppurative and unspecified otitis media, Chronic tubotympanic suppurative otitis media
+∞
94.6
90
*
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
23.7
91.1
132
60
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
80.7
88.2
99
13
TDA90
NOMESCO Finland
Removal wax from ear
20.4
84.9
129
68
H95.0
ICD-10 Finland
Recurrent cholesteatoma of postmastoidectomy cavity
+∞
84.0
80
*
DEB10
NOMESCO Finland
Attico-antro-mastoidectomy
+∞
84.0
80
*
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
432.1
83.7
83
*
H95.1
ICD-10 Finland
Other disorders following mastoidectomy
+∞
79.8
76
*
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
38.7
77.9
99
27
H60.9
ICD-10 Finland
Otitis externa, unspecified
5.7
75.2
231
450
S02CA02
ATC
flumetasone and antiinfectives; otic
5.8
74.7
226
432
H60.4
ICD-10 Finland
Cholesteatoma of external ear
84.9
72.7
81
10
S03CA01
ATC
dexamethasone and antiinfectives; ophthalmic, otic (ophth. and otological prep., corticosteroids and antiinfectives in comb.)
10.2
71.4
146
154
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
30.9
70.2
94
32
H72.9
ICD-10 Finland
Perforation of tympanic membrane, unspecified
68.7
68.9
79
12
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
4.4
67.3
265
674
4151
FHL
Reoperation for chronic otitis media
+∞
62.9
60
*
H65.4
ICD-10 Finland
Other chronic nonsuppurative otitis media
329.4
62.8
63
*
H66.1
ICD-10 Finland
Chronic tubotympanic suppurative otitis media
329.4
62.8
63
*
Z97.4
ICD-10 Finland
Presence of external hearing-aid
5.2
62.0
205
432
H60.3
ICD-10 Finland
Other infective otitis externa
10.8
61.3
121
119
4143
FHL
Atticotomy or atticoanthromy through the ear canal
+∞
58.7
56
*
4150
FHL
Tympanoplasty (including for reasons other than inflammation)
290.2
55.5
56
*
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.4
55.4
588
2981
4146
FHL
Radical cutting (bridge broken)
+∞
54.4
52
*
DFF15
NOMESCO Finland
Speech audiometry
5.3
54.4
175
356
4145
FHL
Tympanomastoidectomy, includes possible tympanoplasty
257.0
49.3
50
*
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
5.1
49.0
165
352
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.1
48.8
932
6102
H74.2
ICD-10 Finland
Discontinuity and dislocation of ear ossicles
+∞
48.1
46
*
38100
ICD-8 Finland
Otitis media without mention of mastoiditis, Acute
+∞
47.1
45
*
R5120
NOMESCO Finland
Preparation of an aid
6.7
47.0
124
196
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
6.0
46.3
134
239
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
+∞
46.0
44
*
4122
FHL
Tympanostomy (tympanic tube)
225.3
43.1
44
*
S03CA04
ATC
hydrocortisone and antiinfectives; ophthalmic, otic (ophth. and otological prep., corticosteroids and antiinfectives in comb.)
6.2
42.7
120
206
H72.1
ICD-10 Finland
Attic perforation of tympanic membrane
115.3
41.9
45
*
H95.8
ICD-10 Finland
Other postprocedural disorders of ear and mastoid process
+∞
41.8
40
*
4141
FHL
Myringoplasty (also for reasons other than inflammation)
+∞
40.8
39
*
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
5.5
40.2
125
243
H60.8
ICD-10 Finland
Other otitis externa
7.1
40.1
101
149
H65.1
ICD-10 Finland
Other acute nonsuppurative otitis media
44.7
39.2
48
11
H65.0
ICD-10 Finland
Acute serous otitis media
15.4
38.6
64
43
DDD05
NOMESCO Finland
Plastic repair of ossicular chain
+∞
36.6
35
*
DEB35
NOMESCO Finland
Radical mastoidectomy with tympanoplasty
+∞
36.6
35
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.6
35.9
288
1213
DCB00
NOMESCO Finland
Excision of lesion of middle ear
+∞
35.5
34
*
38402
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) non definita
+∞
34.5
33
*
38199
ICD-8 Finland
Otitis media without mention of mastoiditis, Unspecified
+∞
33.4
32
*
H61.2
ICD-10 Finland
Impacted cerumen
3.5
33.1
166
510
H65.9
ICD-10 Finland
Nonsuppurative otitis media, unspecified
75.6
32.9
37
5
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
5.5
31.4
96
183
DAX08
NOMESCO Finland
Fitting of hearing aid
4.0
31.4
131
345
DGW00
NOMESCO Finland
Dilatation of eustachian tube
+∞
31.3
30
*
1450
FHL
Otomicroscopy
47.1
30.7
37
8
DCA30
NOMESCO Finland
Exploration of middle ear
152.4
28.7
30
*
H66.2
ICD-10 Finland
Chronic atticoantral suppurative otitis media
+∞
28.2
27
*
38401
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) chronica adhaesiva
+∞
28.2
27
*
ZXC10
NOMESCO Finland
Use of laser
5.9
27.5
79
140
DE2CG
NOMESCO Finland
Acoustic channel extensive MRI examination with high intensity magnet
8.1
27.3
62
79
J01MA02
ATC
ciprofloxacin; systemic
1.7
26.2
720
4975
J01DA01
ATC
[U] cefalexin; systemic
1.7
25.9
1078
8407
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
25.6
499
3075
H68.1
ICD-10 Finland
Obstruction of Eustachian tube
12.4
25.6
46
38
Z98.8
ICD-10 Finland
Other specified postsurgical states
9.1
25.6
54
61
H72.8
ICD-10 Finland
Other perforations of tympanic membrane
50.8
25.3
30
6
J01CA04
ATC
amoxicillin; systemic
1.8
25.1
1352
11339
UDC10
NOMESCO Finland
Tympanoscopy
253.5
24.7
25
*
4144
FHL
Mastoidectomy or aticomastoidectomy
+∞
24.0
23
*
DCW99
NOMESCO Finland
Other operation on eardrum and middle ear
+∞
24.0
23
*
3842A
ICD-9 Finland
Other disorders of tympanic membrane, Perforation of tympanic membrane
+∞
23.0
22
*
38299
ICD-8 Finland
Unspecified otitis media with mastoiditis
+∞
23.0
22
*
H92.0
ICD-10 Finland
Otalgia
3.6
22.5
106
310
R5140
NOMESCO Finland
Monitoring the use of the aid
2.3
22.0
214
988
3820A
ICD-9 Finland
Suppurative and unspecified otitis media, Acute suppurative otitis media
+∞
21.9
21
*
4148
FHL
Radical cutting and cavity filling
+∞
21.9
21
*
H90.8
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unspecified
14.8
21.2
35
24
H66
ICD-10 Finland
Suppurative and unspecified otitis media
5.9
21.1
59
102
ZXA00
NOMESCO Finland
Right side
1.7
20.6
501
3277
S02AA03
ATC
boric acid; otic
8.8
20.6
44
51
DEB00
NOMESCO Finland
Cortical mastoidectomy
111.3
20.6
22
*
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
3.4
19.8
100
309
DED00
NOMESCO Finland
Obliteration of cavity after partial excision of mastoid
+∞
19.8
19
*
H04
ICPC
Ear discharge
3.8
19.1
81
218
H61.3
ICD-10 Finland
Acquired stenosis of external ear canal
17.3
18.7
29
17
DEE00
NOMESCO Finland
Osseous fixation of hearing aid
101.1
18.6
20
*
H69.0
ICD-10 Finland
Patulous Eustachian tube
38.8
18.6
23
6
ZXA05
NOMESCO Finland
Left side
1.7
18.0
471
3129
ZZG00
NOMESCO Finland
Graft of cartilage
53.1
18.0
21
*
H60.5
ICD-10 Finland
Acute otitis externa, noninfective
9.4
17.6
36
39
H70.0
ICD-10 Finland
Acute mastoiditis
63.9
16.8
19
*
4111
FHL
Ear canal extension
+∞
16.7
16
*
H83.1
ICD-10 Finland
Labyrinthine fistula
161.3
15.5
16
*
J01DA06
ATC
[U] cefuroxime; systemic
1.9
15.5
248
1402
H01
ICPC
Ear pain/earache
2.2
15.3
169
825
R4135
NOMESCO Finland
Rehabilitation for hearing problems
4.3
14.9
55
131
H60
ICD-10 Finland
Otitis externa
3.0
14.6
84
286
H73.8
ICD-10 Finland
Other specified disorders of tympanic membrane
+∞
14.6
14
*
38400
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) acuta
+∞
14.6
14
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.3
14.5
142
653
R01AD08
ATC
fluticasone; nasal
1.6
14.4
420
2843
H61.8
ICD-10 Finland
Other specified disorders of external ear
5.7
14.2
40
71
50099
ICD-8 Finland
Hypertrophy of tonsils and adenoids
2.1
14.0
156
762
J01DC02
ATC
cefuroxime; systemic
2.6
14.0
100
392
H90.2
ICD-10 Finland
Conductive hearing loss, unspecified
11.5
13.8
25
22
H91.9
ICD-10 Finland
Hearing loss, unspecified
2.8
13.8
89
328
J01DB01
ATC
cefalexin; oral
1.5
13.7
1342
11845
H74.4
ICD-10 Finland
Polyp of middle ear
+∞
13.6
13
*
DCW00
NOMESCO Finland
Removal of ventilating tube from tympanic membrane
+∞
13.6
13
*
H29
ICPC
Ear symptom/complaint other
2.0
13.5
172
891
EMB30
NOMESCO Finland
Adenotomy
6.5
12.6
32
50
H72
ICD-10 Finland
Perforation of tympanic membrane
70.4
12.6
14
*
H74.3
ICD-10 Finland
Other acquired abnormalities of ear ossicles
+∞
12.5
12
*
H73.1
ICD-10 Finland
Chronic myringitis
+∞
12.5
12
*
DDD20
NOMESCO Finland
Interposition between eardrum and footplate of stapes
+∞
12.5
12
*
DE2DG
NOMESCO Finland
Acoustic channel very extensive MRI examination with high intensity magnet
24.5
12.5
17
7
DDD10
NOMESCO Finland
Interposition between malleus and stapes
130.9
12.4
13
*
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.3
12.2
109
483
4451
FHL
Guitar cutting
4.8
12.1
39
82
R01AD09
ATC
mometasone; nasal
1.5
12.1
644
4973
H80.0
ICD-10 Finland
Otosclerosis involving oval window, nonobliterative
6.0
12.0
32
54
J01DA08
ATC
[U] cefaclor; oral
1.9
11.6
162
869
3824A
ICD-9 Finland
Suppurative and unspecified otitis media, Unspecified suppurative otitis media
+∞
11.5
11
*
R42
ICD-10 Finland
Dizziness and giddiness
1.6
11.3
353
2418
4121
FHL
Tympanic puncture or parasentosis in general anesthesia or operating room
17.1
11.2
17
10
H71
ICPC
Acute otitis media/myringitis
6.4
11.1
28
44
RK520
NOMESCO Finland
NA
8.6
11.0
23
27
DC1BD
NOMESCO Finland
Temporal bone extensive CT
43.6
10.9
13
*
DBD10
NOMESCO Finland
Reconstruction of external auditory canal
110.6
10.4
11
*
DCA40
NOMESCO Finland
Fat patching or other similar technique without opening of tympanic membrane
+∞
10.4
10
*
Z97.8
ICD-10 Finland
Presence of other specified devices
10.7
10.3
19
18
R01BA52
ATC
pseudoephedrine, combinations; oral
1.5
10.2
438
3213
N07CA01
ATC
betahistine; oral
2.0
10.1
127
655
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.6
10.0
308
2095
H02AB06
ATC
prednisolone; systemic
1.4
9.7
726
5908
DBB00
NOMESCO Finland
Excision of lesion of external auditory canal
13.4
9.7
16
12
H74.0
ICD-10 Finland
Tympanosclerosis
100.5
9.4
10
*
38408
ICD-8 Finland
Other inflammatory diseases of ear, Alii definiti
30.2
9.4
12
*
H92.1
ICD-10 Finland
Otorrhoea
17.6
9.4
14
8
5251
FHL
Hypotension
+∞
9.4
9
*
H80.9
ICD-10 Finland
Otosclerosis, unspecified
5.9
9.4
25
43
RK120
NOMESCO Finland
NA
12.4
9.4
16
13
H60.0
ICD-10 Finland
Abscess of external ear
9.6
9.3
18
19
ZXA10
NOMESCO Finland
Bilateral
1.5
8.7
296
2058
RK110
NOMESCO Finland
NA
5.5
8.6
24
44
J35.2
ICD-10 Finland
Hypertrophy of adenoids
5.2
8.5
25
49
3851A
ICD-9 Finland
Other disorders of middle ear and mastoid, Adhesive middle ear disease
+∞
8.3
8
*
3810A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Acute nonsuppurative otitis media
+∞
8.3
8
*
DCB10
NOMESCO Finland
Freeing of adhesions of middle ear
+∞
8.3
8
*
H60.1
ICD-10 Finland
Cellulitis of external ear
5.2
8.2
24
47
38798
ICD-8 Finland
Other disease of ear and mastoid process, Alii definiti
11.7
8.1
14
12
RK320
NOMESCO Finland
NA
4.5
8.1
27
61
WX110
NOMESCO Finland
Local anesthesy
1.3
7.9
1038
9114
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.4
7.8
350
2577
DEW99
NOMESCO Finland
Other operation on mastoid and temporal bone
45.2
7.7
9
*
J01FA10
ATC
azithromycin; systemic
1.3
7.7
808
6858
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.4
7.6
400
3031
H92.2
ICD-10 Finland
Otorrhagia
10.1
7.5
14
14
H81.3
ICD-10 Finland
Other peripheral vertigo
2.6
7.4
51
198
1451
FHL
Otomicroscopy and paper place
+∞
7.3
7
*
DBW99
NOMESCO Finland
Other operation on external auditory canal
+∞
7.3
7
*
N02BE01
ATC
paracetamol; systemic, rectal
1.4
7.1
1401
12958
RK530
NOMESCO Finland
NA
20.1
7.1
10
5
T16
ICD-10 Finland
Foreign body in ear
5.3
7.1
20
38
J01FA09
ATC
clarithromycin; systemic
1.4
7.0
425
3300
AA1AD
NOMESCO Finland
CT of head and brain
1.4
6.9
382
2917
H74.9
ICD-10 Finland
Disorder of middle ear and mastoid, unspecified
40.2
6.8
8
*
DFF59
NOMESCO Finland
Other assessment of balance
4.9
6.7
20
41
H02
ICPC
Hearing complaint
1.6
6.5
186
1241
DC1AA
NOMESCO Finland
Temporalbone X-ray examination
70.1
6.4
7
*
4161
FHL
Exploratory tympanotomy
70.1
6.4
7
*
TDM10
NOMESCO Finland
Puncture of maxillary antrum
2.3
6.4
55
244
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
2.9
6.4
37
131
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
1.9
6.3
86
463
4119
FHL
Other measure in this category
+∞
6.3
6
*
H74.8
ICD-10 Finland
Other specified disorders of middle ear and mastoid
+∞
6.3
6
*
DDA10
NOMESCO Finland
Exploration of ossicular chain
+∞
6.3
6
*
A02BC01
ATC
omeprazole; systemic
1.3
6.2
428
3384
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.4
6.2
257
1857
R01AD12
ATC
fluticasone furoate; nasal
1.4
6.2
358
2751
H73.0
ICD-10 Finland
Acute myringitis
12.6
6.1
10
8
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
1274
11733
1.24
4.86
4.0
4.1
12.8
13.2
mm/h
0.49
1185
10795
777
6895
1.21
4.00
2.0
2.0
93.4
93.9
pmol/l
0.08
413
3596
1252
11653
1.20
3.72
4.0
3.9
14.9
14.9
pmol/l
0.09
1120
10448
1643
15721
1.25
3.64
16.2
15.6
25.9
25.7
mg/l
0.09
1356
12667
1496
14239
1.20
3.15
4.9
4.7
2.1
2.0
mu/l
0.02
1338
12884
1694
16325
1.25
3.14
19.5
18.4
139.7
139.6
mmol/l
0.34
1645
15908
1697
16359
1.25
3.13
19.5
18.5
4.0
4.0
mmol/l
0.30
1648
15915
1058
9788
1.17
3.10
4.8
4.9
6.8
6.8
mmol/l
0.31
992
9189
9
22
4.10
2.88
1.1
1.4
77.5
102.5
ng/l
—
9
22
1313
12412
1.17
2.77
6.8
7.6
78.4
79.6
u/l
0.34
1226
11660
19
86
2.22
2.64
1.0
1.0
—
—
—
0
0
1717
16638
1.23
2.61
10.7
10.7
25.8
26.2
u/l
0.31
1650
16006
78
546
1.45
2.48
2.0
1.5
106.7
186.3
titre
—
6
19
385
3346
1.19
2.34
4.2
3.9
195.9
693.9
ng/l
1.13
325
2748
1587
15311
1.18
2.29
4.7
4.5
4.5
4.5
mmol/l
0.59
1447
14049
14
59
2.38
2.29
1.7
1.2
—
—
—
0
0
580
5233
1.15
2.18
3.3
3.1
1885.6
1629.2
ng/l
0.31
498
4507
1618
15655
1.18
2.16
5.3
5.1
2.6
2.7
mmol/l
0.28
1468
14283
1572
15178
1.17
2.14
4.6
4.5
1.4
1.4
mmol/l
1.49
1419
13827
1138
10751
1.14
2.12
5.0
4.7
1294.9
1833.4
e6/l
0.15
22
169
837
7760
1.14
2.08
3.8
3.8
0.0
0.0
estimate
0.00
133
1503
9
32
2.82
2.00
1.2
1.2
—
—
—
0
0
1505
14511
1.15
1.98
6.3
6.1
40.4
40.3
mmol/mol
0.16
1385
13323
816
7579
1.13
1.94
6.1
6.1
1.2
1.2
mmol/l
0.19
741
6837
889
8304
1.13
1.92
6.8
6.9
1.2
1.2
mmol/l
0.49
764
6975
1773
17329
1.21
1.91
24.1
22.8
4.5
4.5
e12/l
0.70
1718
16818
1772
17319
1.20
1.90
24.2
22.8
246.0
244.8
e9/l
0.33
1724
16863
1773
17332
1.20
1.89
24.3
23.0
135.0
134.7
g/l
0.44
1743
17054
1707
16632
1.18
1.88
19.4
18.4
82.9
81.1
umol/l
0.84
1707
16626
1773
17333
1.20
1.88
24.2
22.9
7.0
6.8
e9/l
1.18
1716
16820
275
2372
1.18
1.83
29.8
27.5
1.5
1.4
inr
0.63
49
334
238
2027
1.20
1.83
4.5
4.6
31.7
32.8
%
0.68
155
1328
585
5339
1.14
1.82
4.0
4.0
7.4
9.8
mg/mmol
0.85
363
3427
35
224
1.57
1.76
4.6
6.5
11.6
11.8
mg/l
0.05
30
209
1573
15260
1.14
1.71
4.9
4.7
6.0
6.0
mmol/l
0.02
1426
13755
379
3373
1.15
1.71
1.8
1.8
1065.5
1173.0
nmol/l
1.49
279
2527
556
5084
1.13
1.67
2.2
2.2
260.5
240.8
u/l
0.12
520
4772
1517
14691
1.14
1.66
4.1
4.0
1.3
1.3
mmol/l
0.10
1374
13275
578
5307
1.13
1.61
3.4
3.2
7.6
7.5
mmol/l
0.27
474
4432
187
1583
1.20
1.56
2.4
2.5
5.6
7.5
ug/l
1.47
157
1390
384
3444
1.14
1.55
4.1
4.2
1.0
1.0
kg/l
0.46
66
509
87
1108
0.78
1.54
1.7
1.7
—
—
—
0
0
62
459
1.36
1.53
1.5
1.6
26.7
14.4
iu/ml
0.17
18
94
5
15
3.34
1.52
2.0
2.9
0.0
0.5
u/field
—
5
15
836
7859
1.11
1.51
3.9
3.8
0.0
0.0
estimate
0.50
136
1462
184
1570
1.19
1.43
4.0
3.0
235.6
222.9
ng/l
0.09
173
1434
1515
14718
1.12
1.42
15.4
14.7
78.3
77.7
ml/min/173m2
0.47
1268
12168
445
4054
1.13
1.41
2.1
2.4
—
—
—
0
0
448
4085
1.12
1.40
1.5
1.6
19.3
20.3
nmol/l
0.70
380
3458
87
690
1.27
1.36
1.9
1.9
39.9
38.6
u/l
0.21
72
601
91
726
1.27
1.35
1.9
1.9
—
—
—
0
0
822
7760
1.10
1.33
5.2
5.1
0.0
0.0
estimate
0.50
144
1517
14
246
0.57
1.32
1.5
1.6
—
—
—
0
0
970
9235
1.10
1.31
8.2
8.9
4.3
4.2
e9/l
0.37
833
8060
474
4355
1.12
1.30
2.5
2.8
7628.2
6154.3
umol/l
0.24
413
3751
5
18
2.78
1.28
1.0
1.1
—
—
—
0
0
5
18
2.78
1.28
1.0
1.1
—
—
—
0
0
1043
9972
1.10
1.27
3.0
3.2
50.1
53.1
u/l
0.41
962
9207
8
35
2.29
1.27
1.1
1.1
—
—
—
0
0
474
4365
1.11
1.24
2.3
2.2
2.7
3.0
mg/l
3.06
398
3697
643
6017
1.10
1.23
4.0
4.0
—
—
—
0
0
765
7229
1.09
1.18
4.7
4.9
35.1
35.0
g/l
0.15
700
6694
691
6501
1.10
1.18
3.9
3.9
119.5
57.1
ng/l
0.33
498
4782
690
6494
1.10
1.16
5.1
5.1
3.1
3.9
ug/l
0.43
604
5803
28
190
1.48
1.16
1.3
1.4
—
—
—
0
0
30
207
1.46
1.15
1.4
1.4
—
—
—
0
0
274
2456
1.13
1.14
1.2
1.2
42.6
36.1
iu/ml
0.18
82
769
553
5156
1.10
1.14
2.6
2.6
55.4
57.3
u/l
0.48
523
4752
17
103
1.66
1.12
1.4
1.3
—
—
—
0
0
17
103
1.66
1.12
1.4
1.3
—
—
—
0
0
119
1407
0.84
1.12
4.1
3.7
1.2
1.2
mmol/l
0.74
100
1212
13
73
1.79
1.11
1.0
1.1
—
—
—
0
0
30
209
1.44
1.10
1.4
1.4
—
—
—
0
0
320
2906
1.12
1.09
2.0
1.8
—
—
—
0
0
598
5608
1.09
1.08
2.9
3.4
2.3
2.3
mmol/l
0.33
518
4849
106
886
1.21
1.08
1.4
1.3
83.6
49.5
au/ml
—
8
39
188
1650
1.15
1.08
3.6
3.6
2.1
1.9
mmol/l
0.23
146
1309
50
644
0.77
1.04
2.6
3.2
33.2
6440.6
u/ml
0.85
41
544
392
3611
1.11
1.03
2.9
2.6
5.2
5.1
e6/l
0.00
334
3191
680
6434
1.09
1.00
2.2
2.2
80.2
77.8
nmol/l
1.29
593
5680
81
665
1.23
1.00
1.8
1.8
—
—
—
0
0
0
29
0.00
0.97
0.0
2.6
—
41.5
—
0
10
42
319
1.32
0.96
1.4
1.8
191.1
203.2
pmol/l
0.54
36
303
29
208
1.40
0.94
1.4
1.4
—
—
—
0
0
133
1151
1.17
0.94
3.7
3.7
5.2
5.2
kpa
0.29
120
1067
16
101
1.59
0.93
1.4
1.8
—
—
—
0
0
12
196
0.61
0.92
1.5
1.6
—
—
—
0
0
190
1692
1.14
0.91
2.1
2.2
134.0
140.8
ug/g
0.13
145
1326
345
3180
1.10
0.91
1.2
1.2
2.5
1.7
u/ml
0.41
98
818
247
2237
1.12
0.90
1.4
1.4
—
—
—
0
0
34
451
0.75
0.90
5.0
3.4
1.8
1.6
mg/l
0.57
28
408
82
683
1.21
0.90
1.0
1.0
—
—
—
0
0
11
182
0.60
0.89
1.6
1.7
—
—
—
0
0
85
714
1.20
0.86
3.8
4.0
24.9
24.8
mmol/l
0.05
77
668
160
1804
0.88
0.86
3.9
4.1
5.7
20.7
ug/l
2.28
133
1510
72
866
0.83
0.86
2.0
1.8
1.5
1.5
g/l
0.01
60
754
801
7674
1.07
0.83
4.0
4.2
—
—
—
0
0
923
8889
1.07
0.82
2.7
2.7
—
—
—
0
0
440
4122
1.09
0.82
1.7
1.6
1.4
1.4
mmol/l
0.93
374
3437
114
991
1.16
0.79
2.6
2.4
27.3
19.6
au/ml
—
6
46
21
293
0.71
0.79
1.4
1.4
—
—
—
0
0
226
2060
1.11
0.76
7.6
7.5
—
—
—
0
0
45
359
1.26
0.76
1.4
1.3
—
—
—
0
0
550
5221
1.07
0.73
4.7
4.5
21.2
21.7
%
0.32
279
2611
6
107
0.56
0.72
1.5
1.2
—
—
—
0
0
289
2675
1.09
0.72
1.8
2.1
29.7
30.1
s
0.41
279
2590
297
2754
1.09
0.71
3.0
3.3
0.8
0.8
mmol/l
0.03
275
2563
28
365
0.76
0.70
1.3
1.3
254.0
238.0
miu/ml
—
10
155
91
1048
0.86
0.69
7.6
7.5
24.6
24.8
mmol/l
0.34
91
1042
9
142
0.63
0.69
1.4
1.6
—
—
—
0
0
30
387
0.77
0.69
2.4
2.5
16.8
15.8
%
0.76
15
190
123
1089
1.14
0.69
3.7
3.7
1.5
1.8
mmol/l
0.51
92
814
5
27
1.85
0.68
1.4
1.0
—
—
—
0
0
139
1243
1.13
0.67
1.8
1.6
—
—
—
0
0
339
3171
1.08
0.67
2.7
3.1
2.5
2.5
mmol/l
0.32
293
2788
183
1663
1.11
0.67
3.7
3.6
5.8
5.8
kpa
0.18
178
1613
176
1596
1.11
0.67
6.2
7.2
11.7
10.5
mmol/l
1.16
167
1519
13
86
1.51
0.66
3.2
3.7
—
—
—
0
0
16
111
1.45
0.66
1.9
1.5
1.0
1.2
promille
0.26
11
90
45
367
1.23
0.65
1.2
1.1
—
—
—
0
0
27
206
1.31
0.65
1.4
1.4
—
—
—
0
0
42
515
0.81
0.65
1.8
1.8
2.5
3.2
mg/l
0.76
32
374
168
1849
0.90
0.64
3.7
3.6
—
—
—
0
0
248
2296
1.09
0.63
5.5
5.6
1.1
1.0
mmol/l
0.39
229
2112
12
177
0.68
0.63
2.7
2.6
—
—
—
0
0
43
351
1.23
0.62
2.8
2.2
3292.1
4735.1
u/l
0.26
15
139
61
516
1.19
0.62
1.3
1.3
—
—
—
0
0
15
104
1.45
0.62
1.3
2.3
—
—
—
0
0
225
2076
1.09
0.62
7.5
7.4
1.1
1.1
mmol/l
0.03
174
1611
11
71
1.55
0.62
1.0
1.2
176.0
215.3
iu/ml
0.33
11
71
8
49
1.64
0.62
2.1
1.3
7.5
9.1
ug/l
—
8
49
44
361
1.22
0.61
1.4
1.4
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.4
—
—
—
0
0
29
227
1.28
0.60
1.8
2.4
11.6
22.8
mg/l
—
8
55
13
186
0.70
0.59
2.7
3.7
—
—
—
0
0
47
563
0.83
0.59
1.8
2.3
38.0
37.3
g/l
0.38
41
486
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
33
410
0.80
0.59
1.4
1.5
—
—
—
0
0
92
811
1.14
0.58
2.2
2.4
0.7
0.7
%
0.03
87
780
20
149
1.35
0.57
1.1
1.4
—
—
—
0
0
20
149
1.35
0.57
1.1
1.4
—
—
—
0
0
20
149
1.35
0.57
1.1
1.4
—
—
—
0
0
6
36
1.67
0.56
2.0
1.2
—
—
—
0
0
23
176
1.31
0.56
2.6
3.1
12.2
5.3
nmol/l
0.39
23
171
13
90
1.45
0.55
1.0
1.5
—
—
—
0
0
13
90
1.45
0.55
1.0
1.5
—
—
—
0
0
13
90
1.45
0.55
1.0
1.5
—
—
—
0
0
13
90
1.45
0.55
1.0
1.5
—
—
—
0
0
10
148
0.67
0.55
1.7
1.5
—
—
—
0
0
37
448
0.82
0.53
1.3
1.7
—
—
—
0
0
45
377
1.20
0.53
1.3
1.3
—
—
—
0
0
45
377
1.20
0.53
1.3
1.3
—
—
—
0
0
17
227
0.75
0.53
1.1
1.4
12328.6
84757.6
e6/l
—
8
136
26
205
1.27
0.52
1.4
1.4
—
—
—
0
0
26
205
1.27
0.52
1.4
1.4
—
—
—
0
0
14
100
1.40
0.51
1.0
1.0
—
—
—
0
0
51
434
1.18
0.51
1.8
2.1
9.3
11.9
mg/l
1.59
45
395
10
145
0.69
0.50
1.0
1.0
—
—
—
0
0
43
508
0.84
0.49
1.5
1.8
—
—
—
0
0
100
901
1.12
0.47
1.2
1.2
146.6
137.6
iu/ml
0.09
41
336
58
665
0.87
0.47
2.3
2.5
10.2
10.5
g/l
0.25
50
566
222
2079
1.08
0.46
7.6
7.4
5.0
5.1
kpa
0.27
215
1987
40
472
0.84
0.46
1.3
1.5
307.4
272.2
ug/g
0.68
27
286
43
365
1.18
0.46
3.8
3.5
19.7
27.8
mg/l
1.44
26
234
222
2080
1.08
0.46
7.6
7.4
12.6
12.1
kpa
0.49
214
1991
881
8595
1.04
0.44
5.4
6.2
11.4
12.0
umol/l
0.77
843
8147
55
628
0.87
0.43
1.5
1.9
—
—
—
0
0
34
285
1.20
0.42
2.7
3.4
1.1
1.7
%
0.27
24
221
38
446
0.85
0.42
1.9
2.4
203.7
196.0
%
0.17
33
426
215
2020
1.07
0.42
2.0
1.7
—
—
—
0
0
17
131
1.30
0.42
1.1
1.3
—
—
—
0
0
17
131
1.30
0.42
1.2
2.0
4.0
6.9
umol/l
1.20
11
89
8
57
1.41
0.42
1.4
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.8
—
17.1
—
0
8
49
426
1.15
0.41
1.2
1.3
—
—
—
0
0
215
2024
1.07
0.40
1.9
1.8
—
—
—
0
0
59
521
1.14
0.40
1.9
1.7
—
—
—
0
0
36
422
0.85
0.40
1.3
1.5
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
25
303
0.82
0.39
1.3
1.6
—
—
—
0
0
7
103
0.68
0.39
1.7
1.5
1.0
1.0
g/l
—
7
103
32
270
1.19
0.38
1.1
1.1
—
—
—
0
0
19
236
0.80
0.38
4.1
3.8
25.9
33.7
u/ml
0.37
19
230
141
1311
1.08
0.37
3.9
3.8
95.5
92.2
ng/l
0.17
118
1126
173
1622
1.07
0.37
2.0
2.2
0.2
0.2
g/l
0.04
162
1508
11
147
0.75
0.37
1.2
1.3
11.6
12.6
u/l
0.12
11
134
5
76
0.66
0.35
1.0
1.2
—
—
—
0
0
35
406
0.86
0.35
4.7
5.0
4.9
5.1
kpa
0.67
35
400
5
78
0.64
0.35
1.4
1.2
230.6
388.5
u/l
—
5
71
85
775
1.10
0.35
1.9
2.0
1.3
2.6
ug/l
0.82
74
686
232
2203
1.06
0.35
6.7
6.7
104.4
104.3
mmol/l
0.06
223
2144
24
199
1.21
0.35
1.3
1.6
57.5
63.7
%
0.33
15
126
29
246
1.18
0.34
1.4
1.5
—
—
—
0
0
45
396
1.14
0.34
1.5
1.7
8380.4
15017.3
e6/l
1.51
28
284
127
1183
1.08
0.33
2.1
2.7
10.6
10.7
g/l
0.10
118
1080
12
91
1.32
0.33
1.8
3.0
—
—
—
0
0
24
200
1.20
0.33
1.3
1.3
0.7
0.6
nmol/l
0.51
24
189
44
387
1.14
0.33
1.2
1.3
25.4
27.4
iu/l
0.16
37
322
19
155
1.23
0.32
1.2
1.2
89.2
57.4
u/l
1.88
11
111
14
176
0.79
0.32
1.1
1.5
—
—
—
0
0
524
5091
1.04
0.32
2.9
3.2
35.8
39.3
u/l
0.28
490
4831
179
1694
1.06
0.31
8.4
8.3
121.0
121.0
g/l
0.01
174
1638
1421
14057
1.04
0.31
18.2
16.7
39.6
39.5
%
0.09
931
9499
24
202
1.19
0.31
1.0
1.1
—
—
—
0
0
185
1755
1.06
0.30
1.3
1.4
—
—
—
0
0
60
543
1.11
0.30
5.1
3.9
3.8
3.9
mmol/l
0.98
55
501
218
2080
1.05
0.29
2.1
2.5
1.7
1.8
%
0.28
188
1837
64
702
0.91
0.29
2.1
2.5
3.8
3.8
g/l
0.07
45
519
8
106
0.75
0.29
1.0
1.1
—
—
—
0
0
8
106
0.75
0.29
1.0
1.1
—
—
—
0
0
8
109
0.73
0.29
1.0
1.1
—
—
—
0
0
8
109
0.73
0.29
1.0
1.1
—
—
—
0
0
8
109
0.73
0.29
1.0
1.1
—
—
—
0
0
51
460
1.11
0.28
1.5
1.6
—
—
—
0
0
77
834
0.92
0.27
4.4
3.8
23.6
24.0
mmol/l
0.47
69
754
16
131
1.22
0.27
1.0
1.1
—
56.8
—
0
13
110
1031
1.07
0.27
1.5
1.5
—
—
—
0
0
16
193
0.83
0.26
1.1
1.5
—
—
—
0
0
21
178
1.18
0.26
1.1
1.4
243.8
289.6
pmol/l
0.25
16
139
39
436
0.89
0.26
2.2
2.3
180.5
87.7
ug/min
0.58
23
267
51
463
1.10
0.25
1.2
1.1
—
—
—
0
0
31
351
0.88
0.25
1.4
1.4
—
—
—
0
0
9
75
1.20
0.25
2.1
2.7
565.4
1319.3
u/ml
—
9
75
118
1113
1.06
0.25
10.1
9.0
0.6
0.7
%
1.05
118
1104
91
853
1.07
0.23
3.4
3.3
4.3
4.5
pmol/l
0.68
79
743
65
702
0.92
0.23
2.1
2.5
—
—
—
0
0
65
702
0.92
0.23
2.1
2.5
7.3
7.5
g/l
0.28
46
533
20
171
1.17
0.23
1.4
1.4
—
—
—
0
0
17
143
1.19
0.23
1.0
1.0
—
—
—
0
0
7
93
0.75
0.22
1.6
1.5
—
—
—
0
0
102
962
1.06
0.22
10.0
9.2
24.2
24.3
mmol/l
0.17
97
897
10
79
1.27
0.22
1.4
1.4
—
—
—
0
0
10
79
1.27
0.22
1.4
1.4
—
—
—
0
0
679
6671
1.03
0.22
3.0
2.8
134.3
143.5
ug/l
0.30
624
6087
51
468
1.09
0.22
1.2
1.1
—
—
—
0
0
439
4286
1.03
0.22
4.5
4.1
0.0
0.0
estimate
0.88
131
1450
22
252
0.87
0.21
1.2
1.4
15797.9
1731.6
e6/l
0.68
15
184
5
42
1.19
0.21
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
4.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
5
43
1.16
0.21
2.4
3.0
—
—
—
0
0
21
240
0.87
0.20
3.1
2.5
33.9
1331.8
u/ml
0.62
21
230
281
2727
1.04
0.20
3.1
3.0
2.4
1.9
e6/l
0.42
149
1531
61
655
0.93
0.20
1.8
2.6
3.1
3.1
g/l
0.13
45
527
32
288
1.11
0.20
1.3
1.2
—
—
—
0
0
482
4721
1.03
0.19
3.5
3.2
0.2
0.5
e6/l
5.31
367
3636
56
603
0.93
0.19
1.9
2.6
0.9
1.3
g/l
0.51
51
519
298
2897
1.03
0.19
2.9
2.8
1.3
1.3
e6/l
0.09
168
1693
12
99
1.21
0.19
1.1
1.2
—
—
—
0
0
21
239
0.88
0.19
1.2
1.1
—
—
—
0
0
6
51
1.18
0.19
1.0
1.1
—
—
—
0
0
23
203
1.13
0.19
3.2
7.9
9.2
7.6
mmol/l
0.42
15
171
13
154
0.84
0.19
1.0
1.1
103.3
96.5
%
0.54
13
145
26
232
1.12
0.18
1.5
1.4
—
—
—
0
0
26
232
1.12
0.18
1.5
1.4
—
—
—
0
0
26
232
1.12
0.18
1.5
1.4
—
—
—
0
0
26
232
1.12
0.18
1.5
1.4
—
—
—
0
0
23
259
0.89
0.18
1.3
1.3
—
—
—
0
0
212
2053
1.04
0.18
3.0
4.0
236.8
248.3
u/l
0.71
203
1938
13
153
0.85
0.18
1.3
1.1
—
—
u/ml
—
0
0
24
214
1.12
0.17
1.6
1.6
—
—
—
0
0
7
62
1.13
0.17
1.1
1.1
—
—
—
0
0
132
1267
1.04
0.17
1.7
2.0
—
—
—
0
0
11
131
0.84
0.17
1.5
1.6
—
—
—
0
0
19
167
1.14
0.17
1.0
1.1
—
—
—
0
0
117
1121
1.05
0.16
10.0
8.9
1.2
1.3
%
1.37
117
1113
12
141
0.85
0.16
1.3
1.4
13.8
13.7
u/l
0.01
12
132
8
70
1.14
0.16
1.0
1.5
—
—
—
0
0
8
70
1.14
0.16
1.0
1.5
—
—
—
0
0
20
177
1.13
0.16
1.4
1.3
7.2
7.4
mmol/l
0.09
12
123
14
162
0.86
0.16
1.8
2.4
—
—
—
0
0
255
2484
1.03
0.16
3.0
2.5
2.3
2.3
g/l
0.32
238
2294
8
72
1.11
0.16
1.0
1.5
—
—
—
0
0
11
130
0.85
0.16
1.5
1.5
—
—
—
0
0
1297
12879
1.02
0.15
19.8
18.9
13.8
13.8
%
0.00
1271
12597
6
79
0.76
0.15
14.2
20.0
1810.2
1527.8
nmol/l
—
6
79
275
2684
1.03
0.15
2.9
2.5
12.5
12.7
umol/l
0.19
252
2476
34
369
0.92
0.15
1.2
1.4
8.6
8.6
u/l
0.00
25
294
16
182
0.88
0.15
1.2
1.0
6.0
2.2
u/ml
—
8
76
243
2370
1.03
0.14
1.3
1.2
14.0
12.4
u/ml
0.13
97
883
7
90
0.78
0.14
1.1
1.5
—
—
—
0
0
13
112
1.16
0.14
1.4
1.4
69.1
71.6
pmol/l
—
7
34
141
1363
1.04
0.14
3.2
2.9
4.5
4.6
kpa
0.18
136
1318
373
3661
1.02
0.14
1.7
1.7
125503755.8
24503080.6
pmol/l
1.11
298
3016
45
421
1.07
0.14
3.0
3.2
0.7
0.8
nmol/l
0.66
33
335
150
1549
0.97
0.14
7.9
6.8
1.3
1.4
mmol/l
1.03
145
1486
9
110
0.82
0.13
1.4
1.5
—
—
—
0
0
19
171
1.11
0.12
1.0
1.1
—
—
—
0
0
37
395
0.94
0.12
1.1
1.2
2.1
10.3
u/ml
—
5
65
23
211
1.09
0.11
1.1
1.1
—
13.9
—
0
10
63
603
1.05
0.10
2.5
3.4
34.4
76.1
mg/l
1.11
57
492
13
146
0.89
0.10
2.2
2.1
0.9
2.0
u/field
—
7
55
14
125
1.12
0.10
1.1
1.2
—
—
—
0
0
5
44
1.14
0.10
1.0
1.1
—
—
—
0
0
19
174
1.09
0.09
2.6
3.5
65.3
57.0
%
0.88
12
113
38
401
0.95
0.09
1.3
1.2
—
—
—
0
0
29
272
1.07
0.09
1.4
1.2
272.7
261.4
u/ml
0.09
21
162
37
390
0.95
0.08
1.2
1.5
—
—
—
0
0
6
57
1.05
0.08
2.0
2.6
—
—
—
0
0
6
57
1.05
0.08
2.0
2.6
—
—
—
0
0
6
57
1.05
0.08
1.0
1.1
1567.5
1590.7
miu/ml
—
6
57
12
107
1.12
0.08
1.3
2.0
—
—
—
0
0
23
214
1.08
0.08
1.2
1.2
1.4
3.4
u/ml
—
7
63
23
214
1.08
0.08
1.0
1.1
3.0
1.8
u/ml
—
9
90
10
113
0.88
0.08
1.1
1.0
688.2
624.5
ng/l
—
5
63
10
113
0.88
0.08
1.1
1.0
25.4
45.5
ng/l
—
5
61
131
1280
1.03
0.08
2.2
2.2
12.1
12.9
nmol/l
0.73
120
1117
5
64
0.78
0.08
1.2
1.0
—
—
—
0
0
18
195
0.92
0.08
1.3
1.5
—
—
—
0
0
14
127
1.10
0.08
1.3
1.2
—
—
—
0
0
7
68
1.03
0.07
1.3
1.2
—
—
—
0
0
8
93
0.86
0.06
1.5
1.5
—
—
—
0
0
131
1285
1.02
0.06
2.5
2.9
66.5
63.5
ml/min/173m2
0.38
56
547
118
1156
1.02
0.06
1.8
1.9
—
—
—
0
0
16
148
1.08
0.06
1.3
1.3
390954.3
130596.1
e6/l
—
7
102
26
274
0.95
0.06
1.5
1.4
117.6
126.2
u/ml
—
7
51
238
2351
1.01
0.06
3.1
2.6
21.7
22.6
%
0.50
190
2000
41
426
0.96
0.06
1.5
1.5
—
—
—
0
0
344
3408
1.01
0.06
1.6
1.7
1.4
1.4
mg/l
0.03
256
2630
25
237
1.06
0.05
1.8
1.5
—
—
—
0
0
373
3762
0.99
0.05
3.3
3.1
0.9
0.8
ug/l
0.64
255
2576
31
324
0.96
0.05
1.3
1.4
—
—
—
0
0
151
1533
0.98
0.05
2.0
2.4
354.3
39.7
u/l
0.49
128
1305
11
100
1.10
0.05
1.0
1.1
—
—
—
0
0
12
110
1.09
0.05
1.1
1.4
—
195.0
—
0
12
34
327
1.04
0.05
1.6
1.8
1.1
0.8
nmol/l
0.85
27
269
11
101
1.09
0.04
1.0
1.1
—
—
—
0
0
32
309
1.04
0.03
1.4
1.4
—
15.8
—
0
9
147
1453
1.01
0.03
2.1
2.2
390.3
370.8
nmol/l
0.61
129
1328
165
1667
0.99
0.03
1.5
1.8
1.5
1.5
%
0.05
142
1430
20
191
1.05
0.03
1.1
1.0
—
—
—
0
0
12
112
1.07
0.03
2.6
2.2
67.4
172.6
ug/min
—
5
26
38
370
1.03
0.03
2.1
2.2
133.3
128.1
g/l
0.63
29
273
22
229
0.96
0.03
1.5
1.5
—
—
—
0
0
13
122
1.07
0.02
1.0
1.1
—
4.8
—
0
6
46
470
0.98
0.02
1.6
1.7
—
—
—
0
0
33
321
1.03
0.02
3.7
3.3
4.7
4.4
e9/l
0.29
33
321
47
461
1.02
0.02
3.7
3.2
24.9
24.9
mmol/l
0.01
40
394
28
288
0.97
0.02
1.0
1.2
14.7
40.2
u/ml
—
5
23
10
107
0.93
0.02
1.1
1.1
—
—
—
0
0
45
443
1.02
0.01
1.3
1.4
—
—
—
0
0
61
603
1.01
0.01
2.6
3.4
41.4
155.2
mg/l
0.65
55
491
12
126
0.95
0.00
1.2
1.1
—
—
—
0
0
20
206
0.97
0.00
1.2
1.2
3.5
5.7
u/ml
—
6
93
34
334
1.02
0.00
4.2
3.5
58.8
59.0
%
0.04
34
334
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
10
105
0.95
0.00
1.2
1.1
—
—
—
0
0
19
195
0.97
0.00
1.1
1.1
—
—
—
0
0
22
225
0.98
0.00
1.3
1.4
—
—
—
0
0
23
235
0.98
0.00
1.1
1.1
343.6
33.3
iu/ml
—
5
53
35
345
1.01
0.00
1.5
1.9
2.7
4.9
iu/l
1.97
13
114
29
291
1.00
0.00
1.4
1.4
—
—
—
0
0
65
645
1.01
0.00
3.4
2.6
—
—
—
0
0
109
1091
1.00
0.00
1.9
1.6
—
—
—
0
0
12
124
0.97
0.00
1.3
1.1
—
136.7
—
0
27
149
1489
1.00
0.00
2.2
2.6
66.2
66.2
g/l
0.01
137
1354
20
204
0.98
0.00
1.0
1.1
119.3
116.2
%
0.26
20
186
35
354
0.99
0.00
1.7
1.6
—
—
—
0
0
72
722
1.00
0.00
1.5
1.3
—
—
—
0
0
59
588
1.00
0.00
2.5
3.4
2.7
1.8
ratio
—
9
49
26
258
1.01
0.00
1.4
1.4
—
—
—
0
0
10
98
1.02
0.00
1.1
1.1
—
—
—
0
0
10
97
1.03
0.00
1.0
2.2
—
—
—
0
0
10
97
1.03
0.00
1.0
2.2
—
—
—
0
0
185
1853
1.00
0.00
2.2
2.7
8.8
9.2
umol/l
0.10
161
1616
0
7
0.00
0.00
0.0
5.0
—
—
—
0
0
5
49
1.02
0.00
1.2
1.3
30.8
21.0
%
—
5
38
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
48
480
1.00
0.00
1.6
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
2.0
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
6
59
1.02
0.00
1.5
2.2
—
—
—
0
0
5
51
0.98
0.00
1.0
1.1
—
—
—
0
0
9
90
1.00
0.00
2.7
2.4
—
—
—
0
0
6
62
0.97
0.00
1.3
3.2
62.7
121.6
umol/l
—
6
37
8
85
0.94
0.00
1.4
1.4
—
—
—
0
0
5
52
0.96
0.00
1.0
1.1
—
—
—
0
0
7
70
1.00
0.00
1.1
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
2.6
—
0
8
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
8.0
—
74.8
—
0
5
5
58
0.86
0.00
1.2
2.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
1745.2
—
0
5
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
63
630
1.00
0.00
3.0
2.8
0.4
0.3
u/ml
0.13
39
363
Mortality – FinRegistry
↥Association
Association between endpoint H8_CHOLEASTOMA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_CHOLEASTOMA | 1.047 [0.94, 1.16] | 0.395 |
| Birth year | 0.997 [0.99, 1.01] | 0.45 |
During the follow-up period (1.1.1998 — 31.12.2019), 785 out of 4102 females with H8_CHOLEASTOMA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_CHOLEASTOMA | 1.029 [0.93, 1.14] | 0.572 |
| Birth year | 0.99 [0.98, 1.0] | 0.038 |
During the follow-up period (1.1.1998 — 31.12.2019), 1025 out of 5237 males with H8_CHOLEASTOMA died.
Mortality risk
Mortality risk for people of age
years, who have H8_CHOLEASTOMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.123% | 0.193% |
| 5 | 0.634% | 1.217% |
| 10 | 1.682% | 3.257% |
| 15 | 3.035% | 6.167% |
| 20 | 5.517% | 10.486% |
Relationships between endpoints
↥Index endpoint: H8_CHOLEASTOMA – Cholesteatoma of middle ear
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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