cholesteatoma of middle ear: A non-neoplastic lesion characterized by the proliferation of keratinizing squamous epithelium in the middle ear that results in the accumulation of keratin and cells. It is usually caused by repeated infections. If left untreated, it may increase in size and destroy the adjacent delicate bones of the middle ear.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2028 |
4. Check minimum number of eventsNone |
2028 |
5. Include endpointsNone |
2028 |
6. Filter based on genotype QC (FinnGen only) |
1944 |
Control definitions (FinnGen only)
- Control exclude
- H8_MIDDLEMASTOID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H65-H75
- Name in latin
- Cholesteatoma auris mediae
Similar endpoints
↥List of similar endpoints to
Cholesteatoma of middle ear
based on the number of shared cases.
Similar with more cases:
- Diseases of middle ear and mastoid
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 17391 | 7390 | 9876 |
| Only index persons | 15196 | 6641 | 8555 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.25 | 0.21 | 0.28 |
| Only index persons | 0.29 | 0.24 | 0.33 |
| Median age at first event (years) | |||
| Whole population | 46.07 | 49.35 | 43.53 |
| Only index persons | 44.52 | 48.24 | 41.62 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1944 | 857 | 1087 |
| Unadjusted period prevalence (%) | 0.41 | 0.30 | 0.50 |
| Median age at first event (years) | 49.04 | 47.36 | 50.36 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 2028
- Matched controls
- 20280
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Z01.1
ICD-10 Finland
Examination of ears and hearing
6.2
321.3
733
1688
3853A
ICD-9 Finland
Other disorders of middle ear and mastoid, Cholesteatoma of middle ear and mastoid
+∞
307.7
346
*
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
135.9
307.7
174
14
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
37.8
307.7
341
108
DFF00
NOMESCO Finland
Pure tone audiometry
7.8
307.7
648
1157
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
169.5
307.7
185
12
H71
ICD-10 Finland
Cholesteatoma of middle ear
+∞
307.7
1641
*
UDC00
NOMESCO Finland
Ear microscopy
14.6
307.7
674
670
DC1AD
NOMESCO Finland
Temporalbone CT
153.6
307.7
334
26
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
345.2
307.7
320
11
38700
ICD-8 Finland
Other disease of ear and mastoid process, Cholesteatoma of ear
+∞
307.7
466
*
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
30.5
301.0
201
73
H66.0
ICD-10 Finland
Acute suppurative otitis media
11.0
296.7
344
370
H65.3
ICD-10 Finland
Chronic mucoid otitis media
360.2
281.2
278
9
H66.9
ICD-10 Finland
Otitis media, unspecified
10.2
244.3
295
333
DEB25
NOMESCO Finland
Attico-antro-mastoidectomy and tympanoplasty
+∞
230.7
217
*
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
103.4
226.5
117
12
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
23.6
207.0
151
69
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
38.3
203.6
126
35
DEA10
NOMESCO Finland
Attico-antrotomy
+∞
201.5
190
*
DCD10
NOMESCO Finland
Tympanoplasty
542.2
201.4
197
*
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
+∞
196.1
185
*
H70.1
ICD-10 Finland
Chronic mastoiditis
+∞
188.5
178
*
DEB30
NOMESCO Finland
Radical mastoidectomy
949.5
180.1
174
*
DCD00
NOMESCO Finland
Myringoplasty
1938.6
177.7
170
*
H60.4
ICD-10 Finland
Cholesteatoma of external ear
88.6
176.6
93
11
TDA90
NOMESCO Finland
Removal wax from ear
16.8
175.3
149
95
H60.9
ICD-10 Finland
Otitis externa, unspecified
6.0
159.4
312
597
H72.9
ICD-10 Finland
Perforation of tympanic membrane, unspecified
38.1
158.4
98
27
H74.1
ICD-10 Finland
Adhesive middle ear disease
1478.0
142.4
137
*
4147
FHL
Radical surgery, cavity filling and middle ear and / or eardrum plastic
1478.0
142.4
137
*
38210
ICD-8 Finland
Chronic otitis media with mastoiditis
+∞
142.4
135
*
S03CA01
ATC
dexamethasone and antiinfectives; ophthalmic, otic
10.4
141.3
162
168
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
21.2
136.1
103
51
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
211.4
134.5
138
7
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
3.4
132.7
653
2487
H65.2
ICD-10 Finland
Chronic serous otitis media
204.8
130.3
134
7
Z97.4
ICD-10 Finland
Presence of external hearing-aid
5.5
129.7
273
555
H60.3
ICD-10 Finland
Other infective otitis externa
9.9
124.1
147
159
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
4.7
123.2
323
790
S02CA02
ATC
flumetasone and antiinfectives; otic
5.3
118.8
258
538
DEB20
NOMESCO Finland
Attico-antro-mastoidectomy and tympanotomy
+∞
115.7
110
*
3821A
ICD-9 Finland
Suppurative and unspecified otitis media, Chronic tubotympanic suppurative otitis media
+∞
109.4
104
*
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
540.0
104.6
103
*
H65.1
ICD-10 Finland
Other acute nonsuppurative otitis media
45.9
98.2
58
13
DFF15
NOMESCO Finland
Speech audiometry
4.8
95.5
234
538
DEB10
NOMESCO Finland
Attico-antro-mastoidectomy
+∞
94.5
90
*
Z3229
NOMESCO Finland
Other healthcare associate professional
3.8
94.4
327
974
H95.1
ICD-10 Finland
Other disorders following mastoidectomy
+∞
93.5
89
*
H65.0
ICD-10 Finland
Acute serous otitis media
17.6
88.8
73
43
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
4.4
87.9
238
591
H95.0
ICD-10 Finland
Recurrent cholesteatoma of postmastoidectomy cavity
446.2
86.8
86
*
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
5.2
85.6
187
389
S03CA04
ATC
hydrocortisone and antiinfectives; ophthalmic, otic
6.7
84.3
138
218
H60.8
ICD-10 Finland
Other otitis externa
7.1
82.4
127
188
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.5
74.5
672
3375
R5120
NOMESCO Finland
Preparation of an aid
5.3
73.2
155
313
H65.4
ICD-10 Finland
Other chronic nonsuppurative otitis media
723.1
71.6
70
*
4151
FHL
Reoperation for chronic otitis media
+∞
70.2
67
*
H68.1
ICD-10 Finland
Obstruction of Eustachian tube
15.2
70.1
62
42
H66.1
ICD-10 Finland
Chronic tubotympanic suppurative otitis media
359.3
70.0
70
*
H61.2
ICD-10 Finland
Impacted cerumen
3.8
69.6
235
682
H65.9
ICD-10 Finland
Nonsuppurative otitis media, unspecified
34.6
69.2
44
13
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
5.4
66.4
137
270
4150
FHL
Tympanoplasty (including for reasons other than inflammation)
+∞
66.0
63
*
4143
FHL
Atticotomy or atticoanthromy through the ear canal
+∞
62.8
60
*
H74.2
ICD-10 Finland
Discontinuity and dislocation of ear ossicles
+∞
60.7
58
*
DAX08
NOMESCO Finland
Fitting of hearing aid
3.6
58.8
212
641
4146
FHL
Radical cutting (bridge broken)
+∞
58.6
56
*
H66
ICD-10 Finland
Suppurative and unspecified otitis media
7.1
55.3
85
125
4145
FHL
Tympanomastoidectomy, includes possible tympanoplasty
552.5
54.8
54
*
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
+∞
53.4
51
*
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.0
52.7
1087
7342
H72.1
ICD-10 Finland
Attic perforation of tympanic membrane
272.7
52.4
53
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.6
52.4
350
1498
H90.8
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unspecified
13.7
50.3
47
35
38100
ICD-8 Finland
Otitis media without mention of mastoiditis, Acute
+∞
50.2
48
*
DEB35
NOMESCO Finland
Radical mastoidectomy with tympanoplasty
+∞
48.1
46
*
4122
FHL
Tympanostomy (tympanic tube)
130.7
48.0
51
*
H95.8
ICD-10 Finland
Other postprocedural disorders of ear and mastoid process
240.4
46.2
47
*
DE2CG
NOMESCO Finland
Acoustic channel extensive MRI examination with high intensity magnet
7.3
45.5
67
94
4141
FHL
Myringoplasty (also for reasons other than inflammation)
160.3
45.0
47
*
DGW00
NOMESCO Finland
Dilatation of eustachian tube
+∞
41.8
40
*
DCB00
NOMESCO Finland
Excision of lesion of middle ear
415.8
41.3
41
*
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
4.0
41.2
120
312
DDD05
NOMESCO Finland
Plastic repair of ossicular chain
405.3
40.2
40
*
Z98.8
ICD-10 Finland
Other specified postsurgical states
7.0
40.0
61
89
ZXC10
NOMESCO Finland
Use of laser
4.9
38.3
86
182
H61.8
ICD-10 Finland
Other specified disorders of external ear
7.9
38.0
52
67
S02AA03
ATC
boric acid; otic
8.5
37.8
49
59
H92.0
ICD-10 Finland
Otalgia
3.4
37.8
146
459
38402
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) non definita
+∞
37.6
36
*
H66.2
ICD-10 Finland
Chronic atticoantral suppurative otitis media
+∞
36.6
35
*
DCA30
NOMESCO Finland
Exploration of middle ear
353.2
35.0
35
*
38199
ICD-8 Finland
Otitis media without mention of mastoiditis, Unspecified
+∞
34.5
33
*
H04
ICPC
Ear discharge
3.8
34.3
109
301
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
32.6
563
3444
4451
FHL
Guitar cutting
7.4
32.3
47
65
R5140
NOMESCO Finland
Monitoring the use of the aid
2.3
31.7
269
1267
EMB30
NOMESCO Finland
Adenotomy
8.7
31.4
40
47
H72.8
ICD-10 Finland
Other perforations of tympanic membrane
42.9
30.9
38
9
38401
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) chronica adhaesiva
+∞
30.3
29
*
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
3.3
29.8
115
361
1450
FHL
Otomicroscopy
30.6
29.5
39
13
ZXE20
NOMESCO Finland
More than three and less than five hours
2.1
29.4
331
1741
3842A
ICD-9 Finland
Other disorders of tympanic membrane, Perforation of tympanic membrane
+∞
29.2
28
*
J01DA01
ATC
[U] cefalexin
1.7
29.0
1224
9563
H60
ICD-10 Finland
Otitis externa
3.1
28.4
122
408
38299
ICD-8 Finland
Unspecified otitis media with mastoiditis
+∞
28.2
27
*
H90.2
ICD-10 Finland
Conductive hearing loss, unspecified
10.1
27.4
31
31
J01MA02
ATC
ciprofloxacin; systemic
1.7
27.4
829
5901
4144
FHL
Mastoidectomy or aticomastoidectomy
+∞
27.1
26
*
J01DC02
ATC
cefuroxime; systemic
3.0
27.1
121
414
H01
ICPC
Ear pain/earache
2.3
26.7
225
1054
H60.5
ICD-10 Finland
Acute otitis externa, noninfective
7.3
25.9
38
53
R4135
NOMESCO Finland
Rehabilitation for hearing problems
4.2
25.6
68
165
3820A
ICD-9 Finland
Suppurative and unspecified otitis media, Acute suppurative otitis media
+∞
25.0
24
*
DCW99
NOMESCO Finland
Other operation on eardrum and middle ear
253.2
24.7
25
*
UDC10
NOMESCO Finland
Tympanoscopy
91.2
24.7
27
*
H61.3
ICD-10 Finland
Acquired stenosis of external ear canal
20.3
23.0
34
17
4148
FHL
Radical cutting and cavity filling
+∞
23.0
22
*
H70.0
ICD-10 Finland
Acute mastoiditis
+∞
23.0
22
*
DE2DG
NOMESCO Finland
Acoustic channel very extensive MRI examination with high intensity magnet
65.8
22.9
26
*
DEB00
NOMESCO Finland
Cortical mastoidectomy
121.4
22.6
24
*
H73.1
ICD-10 Finland
Chronic myringitis
+∞
21.9
21
*
DED00
NOMESCO Finland
Obliteration of cavity after partial excision of mastoid
+∞
21.9
21
*
J01CA04
ATC
amoxicillin; systemic
1.7
21.8
1557
13398
ZXA05
NOMESCO Finland
Left side
1.7
21.5
532
3544
H29
ICPC
Ear symptom/complaint other
2.0
21.1
241
1267
ZXA00
NOMESCO Finland
Right side
1.7
21.0
566
3853
RK320, ,
NOMESCO Finland
6.9
20.8
32
47
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.3
20.7
165
753
J01DA06
ATC
[U] cefuroxime
1.9
20.7
285
1598
H80.0
ICD-10 Finland
Otosclerosis involving oval window, nonobliterative
6.0
20.0
35
59
DDD20
NOMESCO Finland
Interposition between eardrum and footplate of stapes
+∞
18.8
18
*
DEE00
NOMESCO Finland
Osseous fixation of hearing aid
101.0
18.6
20
*
H73.8
ICD-10 Finland
Other specified disorders of tympanic membrane
101.0
18.6
20
*
RK110, ,
NOMESCO Finland
6.7
18.3
29
44
H71
ICPC
Acute otitis media/myringitis
5.8
18.1
33
58
J01DB01
ATC
cefalexin; oral
1.6
17.9
1576
13831
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.3
17.8
138
622
H69.0
ICD-10 Finland
Patulous Eustachian tube
20.2
17.7
26
13
DDD10
NOMESCO Finland
Interposition between malleus and stapes
+∞
17.7
17
*
4111
FHL
Ear canal extension
+∞
17.7
17
*
R01AD08
ATC
fluticasone; nasal
1.6
16.8
493
3398
H74.4
ICD-10 Finland
Polyp of middle ear
+∞
16.7
16
*
DBD10
NOMESCO Finland
Reconstruction of external auditory canal
171.4
16.5
17
*
RK520, ,
NOMESCO Finland
14.4
16.3
27
19
J01DA08
ATC
[U] cefaclor
2.0
15.9
183
962
H80.9
ICD-10 Finland
Otosclerosis, unspecified
5.8
15.9
29
51
ZZG00
NOMESCO Finland
Graft of cartilage
22.2
15.5
22
10
J35.2
ICD-10 Finland
Hypertrophy of adenoids
5.4
15.4
30
56
50099
ICD-8 Finland
Hypertrophy of tonsils and adenoids
2.0
15.4
166
852
H72
ICD-10 Finland
Perforation of tympanic membrane
38.4
15.4
19
5
H91.9
ICD-10 Finland
Hearing loss, unspecified
2.3
15.2
113
500
H92.1
ICD-10 Finland
Otorrhoea
25.2
14.7
20
8
38400
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) acuta
+∞
14.6
14
*
H83.1
ICD-10 Finland
Labyrinthine fistula
53.7
13.8
16
*
R42
ICD-10 Finland
Dizziness and giddiness
1.5
13.6
437
3056
3824A
ICD-9 Finland
Suppurative and unspecified otitis media, Unspecified suppurative otitis media
+∞
13.6
13
*
DCW00
NOMESCO Finland
Removal of ventilating tube from tympanic membrane
+∞
13.6
13
*
H60.1
ICD-10 Finland
Cellulitis of external ear
5.2
13.4
27
52
R01AD09
ATC
mometasone; nasal
1.4
13.3
754
5905
ZXD10
NOMESCO Finland
Scheduled procedure
1.4
13.0
709
5508
DC1BD
NOMESCO Finland
Temporal bone extensive CT
70.3
12.6
14
*
H81.3
ICD-10 Finland
Other peripheral vertigo
2.8
12.5
61
220
DBB00
NOMESCO Finland
Excision of lesion of external auditory canal
17.4
12.5
19
11
H74.3
ICD-10 Finland
Other acquired abnormalities of ear ossicles
130.8
12.4
13
*
R01BA52
ATC
pseudoephedrine, combinations; oral
1.5
12.4
492
3591
H02AB06
ATC
prednisolone; systemic
1.4
12.1
877
7142
RK120, ,
NOMESCO Finland
14.7
11.8
19
13
ZXE10
NOMESCO Finland
More than one and less than three hours
1.4
11.5
666
5205
H74.0
ICD-10 Finland
Tympanosclerosis
+∞
11.5
11
*
DCA40
NOMESCO Finland
Fat patching or other similar technique without opening of tympanic membrane
+∞
11.5
11
*
RK530, ,
NOMESCO Finland
60.3
10.6
12
*
ZXD20
NOMESCO Finland
Day surgery
1.7
10.6
228
1444
ZXA10
NOMESCO Finland
Bilateral
1.5
10.6
351
2459
Z97.8
ICD-10 Finland
Presence of other specified devices
8.0
10.6
23
29
H92.2
ICD-10 Finland
Otorrhagia
10.1
10.5
20
20
4121
FHL
Tympanic puncture or parasentosis in general anesthesia or operating room
14.3
10.5
17
12
3810A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Acute nonsuppurative otitis media
+∞
10.4
10
*
WX110
NOMESCO Finland
Infiltration anesthesia
1.4
10.2
1246
10915
J01DA09
ATC
[U] cefadroxil
1.4
10.2
451
3346
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
3.2
10.2
39
123
38408
ICD-8 Finland
Other inflammatory diseases of ear, Alii definiti
40.3
10.0
12
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.5
9.8
340
2401
4741B
ICD-9 Finland
Chronic disease of tonsils and adenoids, Hypertrophy of tonsils and adenoids[HYPERTROPHIA TONSILLAE PHARYNGICAE]
8.1
9.8
21
26
3890A
ICD-9 Finland
Deafness, Conductive deafness
100.5
9.4
10
*
5251
FHL
Hypotension
+∞
9.4
9
*
DCB10
NOMESCO Finland
Freeing of adhesions of middle ear
+∞
9.4
9
*
DFF10
NOMESCO Finland
Measurement of acoustic impedance (tympanometry and reflex testing)
15.6
9.0
14
9
ZYC03
NOMESCO Finland
Remote contact, text-based
7.1
9.0
21
30
H60.0
ICD-10 Finland
Abscess of external ear
7.5
8.9
20
27
RK420, ,
NOMESCO Finland
24.1
8.9
12
5
J01FA10
ATC
azithromycin; systemic
1.3
8.7
923
7837
M01AE03
ATC
ketoprofen; systemic, rectal
1.3
8.6
655
5300
TDM10
NOMESCO Finland
Puncture of maxillary antrum
2.3
8.6
62
273
DEW99
NOMESCO Finland
Other operation on mastoid and temporal bone
90.4
8.4
9
*
3851A
ICD-9 Finland
Other disorders of middle ear and mastoid, Adhesive middle ear disease
+∞
8.3
8
*
N07CA01
ATC
betahistine; oral
1.7
8.1
142
851
DBB02
NOMESCO Finland
Excision of a neoplasm from external auditory canal
33.5
8.1
10
*
H70
ICPC
Otitis externa
2.8
8.0
40
147
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.4
8.0
462
3574
J01AA02
ATC
doxycycline; systemic
1.3
7.9
1407
12773
J01FA09
ATC
clarithromycin; systemic
1.4
7.7
485
3798
AA1AD
NOMESCO Finland
CT of head and brain
1.4
7.7
515
4072
H74.9
ICD-10 Finland
Disorder of middle ear and mastoid, unspecified
45.1
7.7
9
*
D23.2
ICD-10 Finland
Benign neoplasm: Skin of ear and external auricular canal
3.4
7.7
27
81
DDA00
NOMESCO Finland
Stapedotomy
4.5
7.6
18
40
J01FA01
ATC
erythromycin; systemic
1.6
7.5
198
1318
DE2BG
NOMESCO Finland
Acoustic channel MRI examination with high intensity magnet
3.7
7.5
23
63
G51.0
ICD-10 Finland
Bell palsy
2.4
7.4
48
201
H74.8
ICD-10 Finland
Other specified disorders of middle ear and mastoid
80.4
7.4
8
*
1451
FHL
Otomicroscopy and paper place
+∞
7.3
7
*
DC1AA
NOMESCO Finland
Temporalbone X-ray examination
+∞
7.3
7
*
A02BC01
ATC
omeprazole; systemic
1.3
7.1
487
3858
38798
ICD-8 Finland
Other disease of ear and mastoid process, Alii definiti
7.9
7.1
15
19
50499
ICD-8 Finland
Deflected nasal septum
2.6
7.1
38
146
J01FF01
ATC
clindamycin; systemic
1.4
7.0
456
3583
H02
ICPC
Hearing complaint
1.5
7.0
255
1814
N02BE01
ATC
paracetamol; systemic, rectal
1.4
6.8
1671
15672
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
1.6
6.8
154
989
4161
FHL
Exploratory tympanotomy
40.2
6.8
8
*
T16
ICD-10 Finland
Foreign body in ear
3.6
6.8
21
58
S02CA03
ATC
hydrocortisone and antiinfectives; otic
16.7
6.7
10
6
ZZC00
NOMESCO Finland
Graft of fascia
16.7
6.7
10
6
H90
ICD-10 Finland
Conductive and sensorineural hearing loss
7.2
6.7
15
21
DC1AI
NOMESCO Finland
Cone beam CT of ear
22.6
6.7
9
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.3
6.4
489
3928
Q37.1
ICD-10 Finland
Cleft hard palate with unilateral cleft lip
70.1
6.4
7
*
DCA00
NOMESCO Finland
Biopsy of tympanic membrane or middle ear
70.1
6.4
7
*
74900
ICD-8 Finland
Cleft palate and cleft lip, Cleft palate
70.1
6.4
7
*
UKC02
NOMESCO Finland
Cystoscopy
1.4
6.4
314
2357
D07AB02
ATC
hydrocortisone butyrate; topical
1.3
6.4
482
3868
WX002
NOMESCO Finland
Sedation and analgesia
1.4
6.4
341
2597
H73.0
ICD-10 Finland
Acute myringitis
8.2
6.3
13
16
DFE00
NOMESCO Finland
Insertion of cochlear implant
8.2
6.3
13
16
RK290, ,
NOMESCO Finland
11.1
6.3
11
10
H70.9
ICD-10 Finland
Mastoiditis, unspecified
+∞
6.3
6
*
DGB00
NOMESCO Finland
Obliteration of eustachian tube
+∞
6.3
6
*
TDC10
NOMESCO Finland
Removal of ventilating tube from tympanic membrane
+∞
6.3
6
*
DDA10
NOMESCO Finland
Exploration of ossicular chain
+∞
6.3
6
*
4119
FHL
Other measure in this category
+∞
6.3
6
*
H73.9
ICD-10 Finland
Disorder of tympanic membrane, unspecified
26.8
6.2
8
*
DBW99
NOMESCO Finland
Other operation on external auditory canal
26.8
6.2
8
*
R05DA20
ATC
opium alkaloids and derivatives - combinations
1.3
6.0
416
3293
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
1292
11918
1.23
4.75
4.1
4.1
12.76
13.20
mm/h
0.50
1202
10972
785
7005
1.20
3.72
2.0
2.0
93.64
93.99
pmol/l
0.07
418
3660
1270
11840
1.19
3.62
4.0
3.9
14.94
14.91
pmol/l
0.12
1135
10621
1667
15969
1.25
3.53
16.3
15.6
25.78
25.72
mg/l
0.02
1378
12867
1721
16587
1.25
3.18
19.4
18.4
139.67
139.61
mmol/l
0.43
1672
16168
1075
9942
1.17
3.17
4.8
4.9
6.75
6.81
mmol/l
0.42
1008
9345
1724
16621
1.25
3.17
19.5
18.5
3.99
3.99
mmol/l
0.43
1675
16173
1522
14514
1.19
3.01
4.9
4.7
2.05
2.05
mu/l
0.01
1362
13145
20
87
2.31
3.01
1.0
1.0
—
—
—
0
0
9
23
3.93
2.77
1.1
1.4
77.48
99.83
ng/l
—
9
23
1746
16911
1.23
2.73
10.8
10.7
25.83
26.19
u/l
0.28
1678
16272
1333
12615
1.17
2.72
6.9
7.6
78.36
79.55
u/l
0.34
1246
11871
79
555
1.44
2.46
2.0
1.5
106.67
186.32
titre
—
6
19
392
3396
1.19
2.46
4.2
3.9
214.46
711.53
ng/l
1.14
332
2795
14
59
2.38
2.29
1.7
1.2
—
—
—
0
0
1612
15571
1.17
2.21
4.7
4.5
4.50
4.53
mmol/l
0.54
1471
14298
37
227
1.64
2.15
4.7
6.5
11.61
11.75
mg/l
0.05
32
211
1644
15917
1.17
2.13
5.2
5.1
2.64
2.65
mmol/l
0.21
1493
14538
1597
15433
1.16
2.09
4.6
4.5
1.41
1.43
mmol/l
1.58
1443
14068
586
5306
1.15
2.07
3.3
3.1
1870.84
1620.27
ng/l
0.30
503
4569
1153
10916
1.13
2.01
4.9
4.7
1294.86
1831.99
e6/l
0.15
22
172
1529
14753
1.15
1.95
6.2
6.1
40.43
40.35
mmol/mol
0.12
1407
13550
1800
17595
1.20
1.92
24.4
22.9
40.09
40.19
%
0.12
1660
16346
1801
17607
1.20
1.91
24.2
22.8
6.96
6.84
e9/l
1.11
1743
17084
1801
17608
1.20
1.90
24.2
22.8
4.48
4.46
e12/l
0.68
1745
17087
1800
17598
1.20
1.90
24.3
22.8
245.64
244.76
e9/l
0.22
1751
17135
1801
17612
1.20
1.87
24.4
23.0
135.08
134.73
g/l
0.45
1770
17332
1734
16902
1.18
1.87
19.5
18.3
82.92
81.13
umol/l
0.88
1734
16896
849
7916
1.12
1.86
3.8
3.8
0.00
0.00
estimate
0.75
152
1640
9
34
2.65
1.86
1.2
1.2
—
—
—
0
0
827
7710
1.12
1.80
6.1
6.1
1.21
1.21
mmol/l
0.06
755
7007
241
2058
1.19
1.80
4.5
4.6
31.78
32.76
%
0.60
157
1365
901
8445
1.12
1.79
6.8
6.9
1.21
1.21
mmol/l
0.25
783
7149
192
1607
1.22
1.77
2.3
2.5
5.77
7.49
ug/l
1.26
162
1412
594
5434
1.13
1.77
3.8
3.8
7.35
9.60
mg/mmol
0.79
365
3490
95
733
1.31
1.75
1.9
1.9
—
—
—
0
0
19
104
1.83
1.67
1.5
1.3
—
—
—
0
0
19
104
1.83
1.67
1.5
1.3
—
—
—
0
0
1597
15507
1.14
1.66
4.9
4.7
6.01
6.02
mmol/l
0.07
1447
13981
876
8223
1.11
1.66
18.2
17.3
1.32
1.32
inr
0.04
229
2386
88
1131
0.77
1.65
1.7
1.7
—
—
—
0
0
382
3413
1.15
1.63
1.8
1.8
1070.30
1170.93
nmol/l
1.34
280
2553
1541
14942
1.13
1.59
4.1
4.0
1.29
1.29
mmol/l
0.08
1395
13501
188
1592
1.20
1.56
4.0
3.0
233.13
221.12
ng/l
0.09
177
1454
563
5169
1.12
1.56
2.2
2.2
259.23
240.45
u/l
0.12
527
4853
822
7708
1.11
1.56
6.4
5.8
57.69
57.91
%
0.19
771
7232
63
466
1.36
1.56
1.5
1.6
26.75
14.05
iu/ml
0.17
18
96
835
7838
1.11
1.56
6.6
6.0
26.99
26.88
%
0.10
783
7357
587
5409
1.12
1.53
3.4
3.2
7.55
7.50
mmol/l
0.10
484
4538
452
4118
1.13
1.43
2.1
2.4
—
—
—
0
0
388
3502
1.13
1.42
4.1
4.2
1.02
1.02
kg/l
0.52
67
513
1543
14998
1.12
1.41
15.5
14.8
78.22
77.84
ml/min/173m2
0.27
1294
12415
6
138
0.43
1.39
1.0
1.1
—
0.46
—
0
46
454
4145
1.12
1.38
1.5
1.6
19.22
20.35
nmol/l
0.85
385
3510
85
671
1.28
1.37
1.8
1.8
—
—
—
0
0
847
7997
1.10
1.37
3.9
3.8
0.00
0.00
estimate
0.80
137
1481
5
17
2.95
1.36
2.0
2.8
0.00
0.53
u/field
—
5
17
19
112
1.70
1.35
1.7
1.5
93.00
89.25
umol/l
0.10
19
112
119
1433
0.82
1.32
4.1
3.8
1.23
1.22
mmol/l
0.71
100
1237
555
5142
1.11
1.30
3.3
3.3
377.37
275.86
mg/l
0.21
345
3363
88
704
1.26
1.29
1.9
1.9
39.77
38.52
u/l
0.20
73
613
31
210
1.48
1.28
1.4
1.4
—
—
—
0
0
328
2952
1.13
1.27
2.0
1.8
—
—
—
0
0
985
9394
1.09
1.25
8.5
8.9
4.32
4.25
e9/l
0.36
848
8198
8
36
2.23
1.24
1.1
1.1
—
—
—
0
0
778
7344
1.10
1.24
4.7
4.9
35.10
35.05
g/l
0.08
713
6809
138
1165
1.20
1.23
3.8
3.7
5.20
5.16
kpa
0.26
129
1110
31
212
1.47
1.23
1.4
1.4
—
—
—
0
0
702
6597
1.10
1.23
5.2
5.1
3.07
3.92
ug/l
0.44
614
5895
481
4436
1.11
1.22
2.5
2.8
7422.66
5994.65
umol/l
0.24
425
3857
15
252
0.59
1.22
1.6
1.5
—
—
—
0
0
5
19
2.64
1.21
1.0
1.1
—
—
—
0
0
1058
10133
1.09
1.21
3.0
3.2
49.95
53.03
u/l
0.44
975
9364
480
4429
1.11
1.21
2.3
2.2
2.68
3.00
mg/l
2.86
403
3753
833
7896
1.09
1.20
5.2
5.1
0.00
0.00
estimate
0.50
145
1539
279
2497
1.14
1.19
1.2
1.2
42.81
35.69
iu/ml
0.21
84
800
50
658
0.75
1.18
2.6
3.1
32.53
6290.88
u/ml
0.85
41
557
321
2899
1.13
1.18
1.3
1.4
2.40
2.59
g/l
0.99
204
1754
560
5221
1.10
1.15
2.6
2.6
55.44
74.58
u/l
0.66
530
4812
44
328
1.35
1.11
1.4
1.8
189.42
202.62
pmol/l
0.63
38
310
13
73
1.79
1.11
1.0
1.1
—
—
—
0
0
399
3669
1.11
1.08
2.8
2.6
5.14
5.12
e6/l
0.01
351
3312
28
194
1.45
1.07
1.3
1.4
—
—
—
0
0
649
6112
1.09
1.06
4.0
4.0
—
—
—
0
0
88
723
1.23
1.06
4.0
4.0
24.81
24.81
mmol/l
0.01
80
677
697
6585
1.09
1.06
3.9
3.9
117.61
56.77
ng/l
0.33
508
4850
30
211
1.43
1.06
1.4
1.4
—
—
—
0
0
9
48
1.88
1.00
2.0
1.3
7.43
9.19
ug/l
—
9
48
107
904
1.19
0.99
1.4
1.3
69.10
52.46
au/ml
—
10
52
604
5688
1.09
0.99
2.9
3.4
2.35
2.35
mmol/l
0.34
525
4960
47
363
1.30
0.96
1.4
1.3
—
—
—
0
0
128
1103
1.17
0.95
3.9
3.7
1.44
1.84
mmol/l
0.66
97
823
190
1688
1.14
0.94
3.7
3.6
2.05
1.93
mmol/l
0.17
158
1389
232
2088
1.13
0.93
7.5
7.5
—
—
—
0
0
11
184
0.60
0.92
1.7
1.7
—
—
—
0
0
453
4226
1.09
0.92
3.5
4.0
86.44
86.58
%
0.04
436
4124
84
701
1.21
0.90
1.0
1.0
—
—
—
0
0
16
102
1.57
0.90
1.4
1.8
—
—
—
0
0
193
1723
1.13
0.89
2.1
2.2
136.30
140.31
ug/g
0.07
151
1358
815
7795
1.08
0.89
2.5
2.6
—
—
—
0
0
687
6531
1.08
0.88
2.2
2.2
80.18
77.72
nmol/l
1.31
598
5763
351
3243
1.10
0.88
1.2
1.2
2.49
1.69
u/ml
0.40
101
836
35
460
0.76
0.88
4.9
3.4
1.87
1.62
mg/l
0.68
29
416
251
2281
1.11
0.87
1.4
1.4
—
—
—
0
0
47
371
1.27
0.84
1.1
1.1
—
—
—
0
0
939
9042
1.07
0.84
2.7
2.7
—
—
—
0
0
13
202
0.64
0.83
1.9
1.6
—
—
—
0
0
45
355
1.27
0.81
2.8
2.3
1563.51
4599.06
u/l
1.14
15
143
164
1838
0.88
0.81
3.9
4.1
5.69
20.40
ug/l
2.29
137
1534
143
1261
1.14
0.81
1.8
1.6
—
—
—
0
0
21
294
0.71
0.80
1.4
1.4
—
—
—
0
0
28
374
0.75
0.80
1.3
1.3
254.00
236.02
miu/ml
—
10
161
30
396
0.75
0.79
2.4
2.5
17.01
15.82
%
1.01
16
194
295
2719
1.10
0.79
1.8
2.0
29.70
30.06
s
0.39
285
2632
9
148
0.61
0.79
1.8
1.5
—
—
—
0
0
28
209
1.34
0.75
1.4
1.4
—
—
—
0
0
37
288
1.29
0.75
3.1
3.5
1.08
1.71
%
0.41
32
255
74
874
0.84
0.75
2.0
1.8
1.59
1.53
g/l
0.21
61
762
559
5305
1.07
0.75
4.7
4.5
21.17
21.68
%
0.36
284
2658
42
524
0.80
0.73
1.8
1.7
2.79
3.32
mg/l
0.40
33
389
7
39
1.80
0.72
2.1
1.8
93.57
102.36
nmol/24h
—
7
39
6
110
0.54
0.72
1.5
1.2
—
—
—
0
0
445
4195
1.08
0.71
1.7
1.6
1.43
1.35
mmol/l
0.96
378
3502
115
1010
1.15
0.71
2.6
2.4
29.85
22.74
au/ml
—
8
67
63
528
1.20
0.69
1.3
1.3
—
—
—
0
0
9
146
0.61
0.69
1.4
1.6
—
—
—
0
0
47
572
0.82
0.67
1.8
2.3
38.00
37.36
g/l
0.33
41
502
24
179
1.34
0.67
2.5
3.1
11.79
5.31
nmol/l
0.39
24
174
5
28
1.79
0.66
1.4
1.0
—
—
—
0
0
13
86
1.51
0.66
3.2
3.7
—
—
—
0
0
45
367
1.23
0.65
1.4
1.4
—
—
—
0
0
5
29
1.73
0.64
1.4
1.1
—
—
—
0
0
16
112
1.43
0.63
1.9
1.5
0.99
1.17
promille
0.22
11
89
345
3238
1.08
0.63
2.7
3.1
2.46
2.46
mmol/l
0.08
299
2846
27
208
1.30
0.62
1.4
1.4
—
—
—
0
0
27
208
1.30
0.62
1.4
1.4
—
—
—
0
0
45
370
1.22
0.61
3.8
3.5
18.92
28.04
mg/l
1.81
28
237
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
12
80
1.50
0.59
1.5
1.4
—
—
—
0
0
12
80
1.50
0.59
1.5
1.4
—
—
—
0
0
228
2110
1.09
0.59
7.5
7.3
1.14
1.12
mmol/l
0.03
177
1660
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.3
—
—
—
0
0
171
1869
0.91
0.59
3.6
3.6
—
—
—
0
0
0
23
0.00
0.58
0.0
1.2
—
—
—
0
0
185
1699
1.10
0.57
3.7
3.6
5.86
5.80
kpa
0.23
180
1648
299
2804
1.08
0.57
3.2
3.3
0.82
0.82
mmol/l
0.08
279
2618
6
36
1.67
0.56
2.0
1.2
—
—
—
0
0
15
107
1.40
0.55
1.3
2.3
—
—
—
0
0
58
676
0.85
0.55
2.3
2.5
10.05
10.49
g/l
0.45
53
603
52
441
1.18
0.54
1.8
2.1
9.42
11.84
mg/l
1.47
46
403
20
151
1.33
0.54
1.1
1.4
—
—
—
0
0
20
151
1.33
0.54
1.1
1.4
—
—
—
0
0
20
151
1.33
0.54
1.1
1.4
—
—
—
0
0
51
432
1.19
0.54
1.2
1.3
—
—
—
0
0
14
193
0.72
0.53
2.6
3.7
—
—
—
0
0
11
74
1.49
0.53
1.0
1.2
175.95
210.87
iu/ml
0.29
11
74
34
415
0.82
0.53
1.5
1.5
—
—
—
0
0
250
2339
1.08
0.52
5.6
5.6
1.05
1.04
mmol/l
0.33
231
2149
38
456
0.83
0.51
1.3
1.7
—
—
—
0
0
13
92
1.42
0.50
1.0
1.5
—
—
—
0
0
13
92
1.42
0.50
1.0
1.5
—
—
—
0
0
43
509
0.84
0.50
1.5
1.8
—
—
—
0
0
13
179
0.72
0.50
2.6
2.7
—
—
—
0
0
177
1637
1.09
0.49
6.6
7.1
11.69
10.52
mmol/l
1.17
168
1558
14
102
1.38
0.47
1.0
1.0
—
—
—
0
0
18
233
0.77
0.47
1.2
1.4
12292.11
83175.74
e6/l
—
9
140
132
1208
1.10
0.47
2.2
2.6
10.54
10.67
g/l
0.14
123
1102
896
8733
1.05
0.46
5.5
6.2
11.39
11.99
umol/l
0.82
858
8287
55
632
0.87
0.46
1.5
1.9
—
—
—
0
0
225
2111
1.07
0.45
7.5
7.3
5.05
5.09
kpa
0.22
218
2017
225
2112
1.07
0.44
7.5
7.3
12.51
12.07
kpa
0.41
217
2021
1387
13663
1.05
0.44
19.3
18.4
15.27
15.08
%
0.52
1365
13420
101
915
1.11
0.44
1.2
1.2
145.73
138.13
iu/ml
0.08
42
340
10
69
1.45
0.44
2.8
3.0
22.64
22.75
mu/l
—
10
64
28
229
1.23
0.44
1.8
2.3
11.63
22.78
mg/l
—
8
57
45
386
1.17
0.43
1.3
1.3
—
—
—
0
0
45
386
1.17
0.43
1.3
1.3
—
—
—
0
0
219
2059
1.07
0.42
2.0
1.7
—
—
—
0
0
87
785
1.11
0.41
1.9
1.9
1.30
2.64
ug/l
0.87
76
695
8
58
1.38
0.41
1.4
1.2
—
—
—
0
0
219
2061
1.07
0.41
1.9
1.8
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.8
—
17.13
—
0
8
46
398
1.16
0.41
1.5
1.7
8093.34
14893.53
e6/l
1.60
29
285
176
1644
1.08
0.41
2.0
2.2
0.21
0.21
g/l
0.04
165
1527
19
238
0.80
0.40
4.1
3.9
25.89
34.87
u/ml
0.44
19
232
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
33
278
1.19
0.40
1.8
1.8
4.45
4.73
mmol/24h
0.19
27
234
60
531
1.13
0.40
1.8
1.7
—
—
—
0
0
35
297
1.18
0.39
1.3
1.2
—
—
—
0
0
7
104
0.67
0.39
1.7
1.5
0.97
0.99
g/l
—
7
104
17
133
1.28
0.38
1.2
2.0
4.00
6.93
umol/l
1.20
11
89
143
1329
1.08
0.38
3.9
3.8
96.38
92.30
ng/l
0.22
120
1142
8
112
0.71
0.37
1.0
1.1
—
—
—
0
0
8
112
0.71
0.37
1.0
1.1
—
—
—
0
0
8
112
0.71
0.37
1.0
1.1
—
—
—
0
0
40
461
0.87
0.37
2.2
2.4
210.20
196.22
%
0.35
35
441
37
429
0.86
0.37
1.5
1.5
—
—
—
0
0
17
134
1.27
0.37
1.1
1.3
—
—
—
0
0
533
5163
1.04
0.36
2.9
3.2
35.71
39.14
u/l
0.28
498
4903
25
207
1.21
0.36
1.0
1.1
—
—
—
0
0
200
1887
1.07
0.36
7.7
7.7
95.36
95.60
%
0.21
195
1822
64
713
0.89
0.36
2.1
2.5
3.65
3.70
g/l
0.12
59
643
11
146
0.75
0.36
1.0
1.0
—
—
—
0
0
5
76
0.66
0.35
1.0
1.2
—
—
—
0
0
5
79
0.63
0.35
1.4
1.2
230.60
386.10
u/l
—
5
72
26
309
0.84
0.35
1.5
1.6
—
—
—
0
0
24
199
1.21
0.35
1.4
1.6
63.07
63.55
%
0.02
15
129
45
396
1.14
0.34
1.2
1.3
25.92
27.41
iu/l
0.11
38
330
42
477
0.88
0.33
1.3
1.5
311.32
274.18
ug/g
0.76
28
289
39
444
0.88
0.32
2.1
2.2
180.53
86.82
ug/min
0.59
23
271
168
1585
1.07
0.32
2.3
2.6
67.11
69.70
e9/l
0.47
126
1227
16
197
0.81
0.31
1.9
1.5
—
—
—
0
0
16
197
0.81
0.31
1.9
1.5
—
—
—
0
0
7
97
0.72
0.31
1.6
1.5
—
—
—
0
0
65
714
0.91
0.30
2.1
2.5
7.34
7.45
g/l
0.19
58
643
112
1044
1.08
0.30
1.5
1.5
—
—
—
0
0
24
203
1.18
0.30
1.3
1.3
0.71
0.65
nmol/l
0.45
24
192
65
713
0.91
0.30
2.1
2.5
—
—
—
0
0
29
250
1.16
0.29
1.4
1.5
—
—
—
0
0
12
152
0.79
0.29
1.2
1.2
11.58
12.36
u/l
0.11
12
139
8
109
0.73
0.29
1.0
1.1
—
—
—
0
0
8
109
0.73
0.29
1.0
1.1
—
—
—
0
0
21
176
1.20
0.28
1.0
1.1
—
—
—
0
0
32
279
1.15
0.28
1.1
1.1
—
—
—
0
0
188
1789
1.06
0.28
1.3
1.4
—
—
—
0
0
12
94
1.28
0.28
1.8
2.9
—
—
—
0
0
221
2114
1.05
0.27
2.1
2.5
1.75
1.79
%
0.25
190
1872
32
280
1.15
0.27
1.3
1.2
277.59
259.97
u/ml
0.16
22
165
12
150
0.80
0.27
1.2
1.4
46.27
29.48
%
—
6
94
52
471
1.11
0.27
1.2
1.1
—
—
—
0
0
21
246
0.85
0.26
3.1
2.4
33.92
1276.78
u/ml
0.62
21
240
61
665
0.91
0.26
1.8
2.5
2.99
3.02
g/l
0.12
55
596
218
2090
1.05
0.25
3.0
4.0
239.03
248.45
u/l
0.54
209
1976
9
75
1.20
0.25
2.1
2.7
565.44
1319.27
u/ml
—
9
75
56
611
0.91
0.24
1.9
2.6
0.92
1.24
g/l
0.49
51
526
16
133
1.20
0.24
1.0
1.1
—
55.14
—
0
14
180
1721
1.05
0.24
8.3
8.2
121.16
121.06
g/l
0.02
175
1679
6
82
0.73
0.24
1.7
1.3
1.53
1.54
g/l
—
6
82
538
5261
1.03
0.23
3.7
3.3
58.97
83.71
e6/l
0.65
425
4108
52
476
1.09
0.23
1.2
1.1
—
—
—
0
0
15
179
0.84
0.23
1.0
1.1
2.49
1.66
u/ml
—
7
93
7
92
0.76
0.22
1.1
1.5
—
—
—
0
0
15
125
1.20
0.22
1.3
1.2
—
—
—
0
0
15
178
0.84
0.22
1.5
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
4.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
14
166
0.84
0.20
1.8
2.3
—
—
—
0
0
51
470
1.09
0.20
1.5
1.6
—
—
—
0
0
93
878
1.06
0.20
3.4
3.4
4.33
4.46
pmol/l
0.75
81
761
6
49
1.23
0.20
1.2
1.3
34.67
20.97
%
—
6
38
9
114
0.79
0.20
1.4
1.4
—
—
—
0
0
287
2788
1.03
0.19
3.1
3.0
2.40
1.95
e6/l
0.44
154
1563
15
127
1.18
0.19
1.3
1.1
—
—
—
0
0
16
186
0.86
0.19
1.2
1.0
6.00
2.62
u/ml
—
8
78
25
222
1.13
0.19
2.3
1.7
20.60
24.36
ug/l
0.44
25
217
6
52
1.15
0.19
1.0
1.1
—
—
—
0
0
13
154
0.84
0.19
1.3
1.1
—
—
u/ml
—
0
0
304
2960
1.03
0.18
2.9
2.8
1.33
1.28
e6/l
0.09
173
1726
24
213
1.13
0.18
1.1
1.1
—
12.67
—
0
11
20
175
1.14
0.18
1.4
1.4
—
—
—
0
0
11
132
0.83
0.18
1.5
1.5
—
—
—
0
0
17
147
1.16
0.18
1.0
1.0
—
—
—
0
0
23
258
0.89
0.17
1.3
1.4
14901.19
1589.27
e6/l
0.69
16
189
119
1138
1.05
0.17
10.0
8.9
0.61
0.67
%
1.10
119
1128
17
195
0.87
0.17
1.4
1.5
—
—
—
0
0
688
6782
1.02
0.17
3.0
2.8
134.15
143.14
ug/l
0.29
631
6193
5
66
0.76
0.17
1.4
3.1
60.40
128.44
umol/l
—
5
39
39
423
0.92
0.17
1.5
1.5
—
—
—
0
0
12
101
1.19
0.16
1.1
1.2
—
—
—
0
0
489
4804
1.02
0.16
3.5
3.2
0.23
0.50
e6/l
5.60
382
3722
378
3702
1.03
0.16
1.7
1.7
124252892.42
26319667.25
pmol/l
1.07
301
3051
8
70
1.14
0.16
1.0
1.5
—
—
—
0
0
8
70
1.14
0.16
1.0
1.5
—
—
—
0
0
8
71
1.13
0.16
1.6
1.2
—
—
—
0
0
23
206
1.12
0.16
3.2
7.8
9.19
7.59
mmol/l
0.42
15
172
8
72
1.11
0.16
1.0
1.5
—
—
—
0
0
13
111
1.17
0.15
1.3
1.4
—
195.00
—
0
12
26
235
1.11
0.15
1.5
1.4
—
—
—
0
0
26
235
1.11
0.15
1.5
1.4
—
—
—
0
0
26
235
1.11
0.15
1.5
1.4
—
—
—
0
0
26
235
1.11
0.15
1.5
1.4
—
—
—
0
0
6
79
0.76
0.15
14.2
19.9
1817.33
1511.95
nmol/l
—
6
79
24
216
1.11
0.15
1.6
1.6
—
—
—
0
0
22
244
0.90
0.14
1.3
1.1
—
—
—
0
0
17
150
1.13
0.14
1.2
1.3
390954.29
128445.12
e6/l
—
7
102
13
112
1.16
0.14
1.4
1.4
114.25
176.04
pmol/l
1.43
13
112
33
357
0.92
0.14
1.4
1.4
—
—
—
0
0
8
97
0.82
0.13
1.5
1.5
—
—
—
0
0
443
4359
1.02
0.13
4.4
4.1
0.00
0.00
estimate
0.88
132
1471
34
315
1.08
0.13
1.4
1.4
—
15.75
—
0
9
133
1287
1.04
0.13
1.7
2.0
—
—
—
0
0
24
219
1.10
0.12
1.2
1.2
1.43
3.32
u/ml
—
7
65
13
148
0.88
0.12
2.2
2.1
0.86
1.98
u/field
—
7
57
19
171
1.11
0.12
1.0
1.1
—
—
—
0
0
14
158
0.89
0.12
1.0
1.1
103.71
96.03
%
0.70
14
149
45
424
1.06
0.12
3.0
3.2
0.74
0.82
nmol/l
0.67
33
336
10
116
0.86
0.12
1.1
1.0
25.40
45.30
ng/l
—
5
64
10
116
0.86
0.12
1.1
1.0
688.20
633.92
ng/l
—
5
66
38
405
0.94
0.12
1.1
1.2
2.14
10.33
u/ml
—
5
65
13
114
1.14
0.11
2.7
2.2
67.40
166.48
ug/min
—
5
27
68
651
1.05
0.11
3.4
2.6
—
—
—
0
0
38
404
0.94
0.11
1.3
1.2
—
—
—
0
0
246
2412
1.02
0.11
1.3
1.2
14.33
12.29
u/ml
0.18
99
895
24
260
0.92
0.11
1.3
1.3
—
—
—
0
0
118
1145
1.03
0.10
10.0
8.8
1.22
1.33
%
0.72
118
1136
38
358
1.06
0.10
1.8
1.6
—
—
—
0
0
257
2524
1.02
0.10
3.0
2.5
2.31
2.29
g/l
0.30
240
2331
5
44
1.14
0.10
1.0
1.1
—
—
—
0
0
5
46
1.09
0.09
1.0
1.2
—
—
—
0
0
31
330
0.94
0.09
1.3
1.4
—
—
—
0
0
35
330
1.06
0.09
1.5
1.9
1.06
0.82
nmol/l
0.86
27
272
13
145
0.90
0.09
1.2
1.4
13.31
13.89
u/l
0.08
13
136
143
1396
1.03
0.09
3.2
2.9
4.49
4.58
kpa
0.18
138
1350
277
2727
1.02
0.09
2.9
2.5
12.58
12.77
umol/l
0.19
255
2533
18
196
0.92
0.09
1.3
1.5
—
—
—
0
0
6
58
1.03
0.08
1.0
1.1
1567.50
1614.98
miu/ml
—
6
58
6
58
1.03
0.08
1.0
1.1
—
—
—
0
0
13
144
0.90
0.08
2.1
2.2
—
—
—
0
0
40
381
1.05
0.08
2.1
2.2
133.90
127.95
g/l
0.80
30
280
5
65
0.77
0.08
1.2
1.0
—
—
—
0
0
7
66
1.06
0.08
1.1
1.1
—
—
—
0
0
12
133
0.90
0.07
1.6
1.5
—
—
—
0
0
154
1570
0.98
0.07
2.0
2.4
347.18
39.35
u/l
0.49
131
1340
133
1302
1.02
0.07
2.2
2.2
12.02
12.83
nmol/l
0.65
122
1149
46
478
0.96
0.06
1.5
1.6
—
—
—
0
0
133
1305
1.02
0.06
2.4
2.9
66.35
63.29
ml/min/173m2
0.41
57
553
11
99
1.11
0.06
1.0
2.1
—
—
—
0
0
11
99
1.11
0.06
1.0
2.1
—
—
—
0
0
113
1107
1.02
0.06
1.9
1.6
—
—
—
0
0
150
1475
1.02
0.06
2.1
2.2
386.78
371.28
nmol/l
0.46
131
1347
12
109
1.10
0.06
1.3
1.8
—
—
—
0
0
23
217
1.06
0.06
1.0
1.1
2.67
2.16
u/ml
—
10
118
187
1896
0.98
0.05
2.1
2.7
8.72
9.22
umol/l
0.12
163
1654
25
237
1.06
0.05
1.1
1.1
343.60
58.74
iu/ml
—
5
54
50
484
1.03
0.05
1.7
1.8
—
—
—
0
0
46
446
1.03
0.04
1.3
1.4
—
—
—
0
0
63
615
1.03
0.04
2.5
3.4
34.37
75.36
mg/l
1.11
57
502
379
3817
0.99
0.04
3.3
3.1
0.90
0.77
ug/l
0.64
259
2612
34
328
1.04
0.04
3.8
3.3
4.73
4.37
e9/l
0.29
34
328
119
1173
1.02
0.04
1.8
1.9
—
—
—
0
0
39
402
0.97
0.04
1.4
1.4
—
—
—
0
0
241
2390
1.01
0.03
3.1
2.6
21.84
22.66
%
0.43
193
2036
11
102
1.08
0.03
1.0
1.1
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
10
108
0.93
0.03
1.2
1.1
—
—
—
0
0
10
108
0.93
0.03
1.1
1.2
—
—
—
0
0
349
3473
1.01
0.02
1.6
1.7
1.38
1.37
mg/l
0.02
261
2678
35
341
1.03
0.02
4.4
3.5
58.54
58.95
%
0.06
35
341
59
600
0.98
0.02
2.5
3.4
2.68
1.78
ratio
—
9
50
20
192
1.04
0.02
1.1
1.0
—
—
—
0
0
151
1522
0.99
0.02
2.2
2.6
66.24
66.30
g/l
0.03
139
1387
25
242
1.03
0.02
1.8
1.5
—
—
—
0
0
11
103
1.07
0.02
1.0
1.1
—
—
—
0
0
30
292
1.03
0.02
1.5
1.4
—
—
—
0
0
29
298
0.97
0.02
1.0
1.2
14.72
40.48
u/ml
—
5
24
170
1690
1.01
0.01
1.5
1.8
1.54
1.53
%
0.06
146
1451
19
197
0.96
0.01
1.1
1.1
—
—
—
0
0
36
353
1.02
0.01
1.5
1.9
2.75
4.79
iu/l
1.85
13
117
13
124
1.05
0.00
1.0
1.1
—
4.83
—
0
6
12
126
0.95
0.00
1.2
1.1
—
—
—
0
0
22
226
0.97
0.00
1.3
1.4
—
—
—
0
0
37
376
0.98
0.00
1.3
1.4
10.02
8.70
u/l
0.22
27
300
13
125
1.04
0.00
1.3
1.1
—
136.67
—
0
27
10
101
0.99
0.00
1.1
1.1
—
—
—
0
0
23
231
1.00
0.00
1.6
1.5
—
—
—
0
0
26
259
1.00
0.00
1.4
1.4
—
—
—
0
0
28
279
1.00
0.00
1.5
1.4
117.57
124.90
u/ml
—
7
52
61
615
0.99
0.00
2.6
3.4
41.39
153.12
mg/l
0.65
55
501
73
732
1.00
0.00
1.5
1.3
—
—
—
0
0
21
208
1.01
0.00
1.0
1.1
121.62
115.73
%
0.54
21
190
29
287
1.01
0.00
1.5
1.5
—
—
—
0
0
29
287
1.01
0.00
1.5
1.5
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
65
647
1.00
0.00
3.5
2.8
0.36
0.35
u/ml
0.12
41
371
5
52
0.96
0.00
1.0
1.1
—
—
—
0
0
9
91
0.99
-0.00
2.7
2.4
—
—
—
0
0
5
53
0.94
-0.00
1.0
1.1
—
—
—
0
0
7
70
1.00
-0.00
1.3
1.2
—
—
—
0
0
6
60
1.00
-0.00
2.0
2.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
8.0
—
74.80
—
0
5
8
85
0.94
-0.00
1.4
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
65
0.92
-0.00
1.2
1.4
180.83
168.33
mmol/24h
—
6
65
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
60
1.00
-0.00
1.2
2.3
—
—
—
0
0
21
210
1.00
-0.00
1.1
1.2
3.50
5.67
u/ml
—
6
96
0
8
0.00
-0.00
0.0
1.4
—
2.63
—
0
8
5
54
0.93
-0.00
3.6
2.4
—
44769.10
—
0
10
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
2.04
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
1745.20
—
0
5
6
60
1.00
-0.00
2.0
2.5
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_CHOLEASTOMA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_CHOLEASTOMA | 1.047 [0.94, 1.16] | 0.395 |
| Birth year | 0.997 [0.99, 1.01] | 0.45 |
During the follow-up period (1.1.1998 — 31.12.2019), 785 out of 4102 females with H8_CHOLEASTOMA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_CHOLEASTOMA | 1.029 [0.93, 1.14] | 0.572 |
| Birth year | 0.99 [0.98, 1.0] | 0.038 |
During the follow-up period (1.1.1998 — 31.12.2019), 1025 out of 5237 males with H8_CHOLEASTOMA died.
Mortality risk
Mortality risk for people of age
years, who have H8_CHOLEASTOMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.123% | 0.193% |
| 5 | 0.634% | 1.217% |
| 10 | 1.682% | 3.257% |
| 15 | 3.035% | 6.167% |
| 20 | 5.517% | 10.486% |
Relationships between endpoints
↥Index endpoint: H8_CHOLEASTOMA – Cholesteatoma of middle ear
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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