Risteys · I9

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — I97, I98, I99 Hospital discharge:* ICD-9 — 4590A\|459[8-9] Hospital discharge: ICD-8 — 4581\|4589 Cause of death: ICD-10 — I97, I98, I99 Cause of death:* ICD-9 — 4590A\|459[8-9] Cause of death: ICD-8 — 4581\|4589 2 out of 7 registries used, show all original rules.	1336
4. Check minimum number of events None	1336
5. Include endpoints None	1336
6. Filter based on genotype QC (FinnGen only)	1336

	All	Female	Male
Number of individuals
Whole population	8785	4639	4036
Only index persons	6572	3616	2956
Unadjusted period prevalence (%)
Whole population	0.12	0.13	0.11
Only index persons	0.12	0.13	0.11
Median age at first event (years)
Whole population	62.77	62.32	63.22
Only index persons	60.58	59.70	61.65

	All	Female	Male
Number of individuals	1336	717	619
Unadjusted period prevalence (%)	0.26	0.24	0.27
Median age at first event (years)	59.75	57.66	62.18

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
1197: Matched controls
11971

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

I97.0

ICD-10 Finland

Postcardiotomy syndrome

+∞

323.0

484

I97.2

ICD-10 Finland

Postmastectomy lymphoedema syndrome

429.7

323.0

339

115

Kela drug reimbursment

Breast cancer

8.1

124.6

311

498

FXA00

NOMESCO Finland

Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure

12.8

123.1

231

220

PJD52

NOMESCO Finland

Block dissection of axillary lymph nodes

14.1

117.1

209

177

HAC20

NOMESCO Finland

Total mastectomy

11.9

107.5

208

FM1BE

NOMESCO Finland

Cardiac ultrasound examination through oesophagus

7.7

99.6

253

404

I99

ICD-10 Finland

Other and unspecified disorders of circulatory system

359.0

98.5

Z95.1

ICD-10 Finland

Presence of aortocoronary bypass graft

9.1

92.5

207

268

HA1AE

NOMESCO Finland

Ultrasound examination of mammary glands

7.5

88.6

227

363

Z95.2

ICD-10 Finland

Presence of prosthetic heart valve

14.6

88.0

153

119

FNA01

NOMESCO Finland

Anastomosis to coronary artery from internal mammary artery, one distal anastamosis

8.1

85.5

206

299

HAE10

NOMESCO Finland

Reconstruction of breast using graft or flap

27.7

85.3

118

FN1AC

NOMESCO Finland

Angiography of heart and/or coronary arteries

3.8

83.8

468

1743

PJ1AN

NOMESCO Finland

Lymphsystem isotope imaging

213.9

78.2

B01AA03

ATC

warfarin; systemic

3.6

77.9

463

1790

C50.41

ICD-10 Finland

Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor

6.9

74.5

200

337

H02AB02

ATC

dexamethasone; systemic

4.9

74.2

274

681

I97.1

ICD-10 Finland

Other functional disturbances following cardiac surgery

+∞

73.7

C03CA01

ATC

furosemide; systemic

3.1

72.0

562

2625

GD1AA

NOMESCO Finland

Thorax X-ray examination

3.0

71.6

721

3997

HA1AA

NOMESCO Finland

X-ray mammography

5.8

71.4

222

452

I20.81

ICD-10 Finland

Other angina pectoris stenosed coronary artery

5.2

69.3

240

553

WX872

NOMESCO Finland

Intensive care

6.9

68.1

181

299

L02BA01

ATC

tamoxifen; oral

8.5

65.3

150

198

WB113

NOMESCO Finland

Multiple adjuvant cytostatic therapy

7.6

64.3

160

239

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

3.6

61.9

339

1189

8500/3-C50.9

ICD-O-3

Infiltrating duct carcinoma, NOS, of breast, NOS

6.5

58.9

164

286

PJW99

NOMESCO Finland

Other operation on lymphatic system

48.6

57.0

FEB10

NOMESCO Finland

Decompression and drainage of pericardium

300.4

56.7

ZZQ70

NOMESCO Finland

Free microvascular graft of lymph nodes

562.5

55.0

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

3.0

53.8

396

1692

B01AB05

ATC

enoxaparin; parenteral

2.7

53.2

505

2530

TFB00

NOMESCO Finland

Cathetrisation of pulmonal artery

13.3

52.2

AN1

Coronary angiography

3.6

51.9

274

918

HAE20

NOMESCO Finland

Reconstruction of areola and mamilla using graft or flap

18.7

50.9

QCJ00

NOMESCO Finland

Liposuction in upper limb

266.1

50.5

A03FA01

ATC

metoclopramide; systemic, rectal

2.9

48.9

366

1566

TPH07

NOMESCO Finland

Cathetrisation of artery

3.7

48.6

237

740

L02BG04

ATC

letrozole; oral

5.2

48.0

159

340

I25.1

ICD-10 Finland

Atherosclerotic heart disease

2.8

48.0

411

1908

A04AA02

ATC

granisetron; systemic, transdermal

5.1

47.5

160

349

Angiography of the heart and coronary arteries

4.7

47.2

175

423

I89.0

ICD-10 Finland

Lymphoedema, not elsewhere classified

28.8

46.5

TQW20

NOMESCO Finland

Tatoe

20.3

45.8

FM1AE

NOMESCO Finland

Standard cardiac ultrasound examination

2.9

45.5

332

1386

WW502

NOMESCO Finland

Autotransfusion

34.4

45.5

FMD00

NOMESCO Finland

Replacement of aortic valve using mechanical prosthesis

25.0

45.4

I35.0

ICD-10 Finland

Aortic (valve) stenosis

4.6

45.0

168

408

ZXE20

NOMESCO Finland

More than three and less than five hours

3.2

44.4

276

1032

Coronary artery bypass surgery

9.5

43.6

104

A04AD12

ATC

aprepitant; systemic

11.7

43.4

ZXE30

NOMESCO Finland

More than five and less than seven hours

5.1

43.2

146

318

X76

ICPC

Malignant neoplasm breast female

11.7

42.9

I35.1

ICD-10 Finland

Aortic (valve) insufficiency

5.1

41.7

140

303

WX408

NOMESCO Finland

General anesthesy, balanced

2.5

41.5

425

2149

YG1BD

NOMESCO Finland

Extensive CT examination of thorax for dose design of radiotherapy

6.8

40.9

108

173

C50.81

ICD-10 Finland

Overall malignant tumor of the mammary gland, ductal tumor

12.5

40.0

C50.99

ICD-10 Finland

Breast, unspecified

7.2

39.7

100

150

C50

ICD-10 Finland

Malignant neoplasm of breast

8.3

39.4

116

206

Kela drug reimbursment

Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease

2.7

39.4

342

1565

A46

ICD-10 Finland

Erysipelas

3.0

39.3

259

998

FMD10

NOMESCO Finland

Replacement of aortic valve using biological prosthesis

10.2

39.2

H02AB06

ATC

prednisolone; systemic

2.2

38.7

651

4160

WB103

NOMESCO Finland

Simple adjuvant cytostatic therapy

6.3

37.4

103

175

45899

ICD-8 Finland

Other disease of circulatory system, Other and unspecified circulatory disease

+∞

36.6

C07AB07

ATC

bisoprolol; oral

2.2

35.9

673

4456

K83

ICPC

Heart valve disease NOS

14.7

34.9

ZX012

NOMESCO Finland

Radiotherapy with large shaped fields - isocentric therapy

4.4

34.7

134

334

ZXD05

NOMESCO Finland

Urgent procedure

2.3

34.2

448

2503

ZZQ00

NOMESCO Finland

Free microvascular graft of skin

19.7

33.7

PH1AE

NOMESCO Finland

Ultrasound examination of upper extremity veins

10.1

33.1

THW99

NOMESCO Finland

Other minor procedure in surgery of mammary gland

8.3

32.7

L03AA13

ATC

pegfilgrastim; parenteral

5.5

32.6

101

198

C50.90

ICD-10 Finland

Malignant tumor in other or unspecified location in mammary gland without histology

10.1

32.6

NK6AN

NOMESCO Finland

Total body bone isotope imaging

6.3

32.5

150

WB203

NOMESCO Finland

Simple adjuvant hormone therapy of malignancy

7.0

32.4

124

HA013

NOMESCO Finland

Radiotherapy after total ablation of mammary gland

11.9

32.3

I48

ICD-10 Finland

Atrial fibrillation and flutter

2.3

31.9

381

2022

FKB10

NOMESCO Finland

Annuloplasty of mitral valve for insufficiency using ring

16.1

31.4

I97.9

ICD-10 Finland

Postprocedural disorder of circulatory system, unspecified

+∞

31.4

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

3.9

31.3

138

388

FNC20

NOMESCO Finland

Aorto-coronary venous bypass with two distal anastomoses

7.7

31.1

102

I97.8

ICD-10 Finland

Other postprocedural disorders of circulatory system, not elsewhere classified

+∞

30.3

C01DA14

ATC

isosorbide mononitrate; oral

2.5

30.3

279

1294

HAD30

NOMESCO Finland

Reduction mammoplasty with transposition of areola

5.9

30.3

156

C50.40

ICD-10 Finland

Malignant tumor of the upper outer quadrant of the mammary gland, no histological veryfication

8.2

30.0

I50.9

ICD-10 Finland

Heart failure, unspecified

2.6

29.9

247

1077

I34.1

ICD-10 Finland

Mitral (valve) prolapse

6.5

29.5

129

HA1CG

NOMESCO Finland

Extensive MRI examination of mammary gland with high intensity magnet

10.1

29.4

I35.2

ICD-10 Finland

Aortic (valve) stenosis with insufficiency

6.4

29.2

131

FNC30

NOMESCO Finland

Aorto-coronary venous bypass with three distal anastomoses

7.7

28.4

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

2.1

28.0

466

2830

I34.09

ICD-10 Finland

Mitral (valve) insufficiency

4.9

27.9

203

WX404

NOMESCO Finland

Intravenous generell anesthesy

2.3

27.8

305

1539

C03DA01

ATC

spironolactone; oral

2.9

27.8

191

744

I31.9

ICD-10 Finland

Disease of pericardium, unspecified

30.9

27.3

HAE99

NOMESCO Finland

Other reconstruction of breast

18.1

27.2

ZXE40

NOMESCO Finland

More than seven and less than nine hours

6.2

27.0

125

TPH15

NOMESCO Finland

Insertion of central venous catheter through external or internal jugular vein

3.6

26.8

130

394

A49.9

ICD-10 Finland

Bacterial infection, unspecified

2.8

26.6

193

774

FWD00

NOMESCO Finland

Reoperation for superficial haemorrhage in surgery of heart and major thoracic vessels

19.1

25.8

213

Kela drug reimbursment

Fat metabolism disorder associated with chronic coronary artery disease

3.1

25.6

154

547

WX402

NOMESCO Finland

General anaesthesia

2.4

25.6

244

1143

1CD02

NOMESCO Finland

16.3

25.5

FM1DE

NOMESCO Finland

Doppler ultrasound examination of heart

2.9

25.1

168

641

I31.3

ICD-10 Finland

Pericardial effusion (noninflammatory)

39.7

25.0

A04AA55

ATC

palonosetron, combinations; systemic

5.8

24.6

128

Catheterization and pressure measurement of the left side of the heart

7.1

24.6

TFC10

NOMESCO Finland

Catheterisation of left atrium or ventricle

7.7

24.3

WF003

NOMESCO Finland

Adjuvant radiotherapy

4.8

24.2

187

I50.0

ICD-10 Finland

Congestive heart failure

3.0

24.2

147

526

TPH04

NOMESCO Finland

Cathetrisation of vein

2.2

24.2

302

1603

45898

ICD-8 Finland

Other disease of circulatory system, Alii definiti

+∞

24.0

4590A

ICD-9 Finland

Other disorders of circulatory system, Haemorrhage, unspecified

+∞

24.0

J01DB01

ATC

cefalexin; oral

2.1

24.0

961

7923

GA4YT

NOMESCO Finland

Puncture of pleura with ultrasound guidance

5.1

23.9

158

Y83

ICD-10 Finland

Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

3.1

23.9

142

500

PJA12

NOMESCO Finland

Sentinel node biopsy

3.1

23.8

140

490

ZX120

NOMESCO Finland

Intravenous

2.8

23.8

162

625

TFP20

NOMESCO Finland

Cardiodefibrillation

3.1

23.7

140

492

I25.9

ICD-10 Finland

Chronic ischaemic heart disease, unspecified

2.6

23.6

185

774

I71.2

ICD-10 Finland

Thoracic aortic aneurysm, without mention of rupture

5.0

23.5

161

HAB40

NOMESCO Finland

Wedge excision of mammary gland

3.8

23.3

104

294

A02BC02

ATC

pantoprazole; systemic

1.9

23.2

800

6185

4598X

ICD-9 Finland

Other disorders of circulatory system, Other specified disorders of circulatory system

+∞

23.0

L02BG06

ATC

exemestane; oral

8.8

22.7

C01DA02

ATC

glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal

2.1

22.7

317

1758

ZX080

NOMESCO Finland

Image guided radiotherapy

6.6

22.2

L03AA14

ATC

lipegfilgrastim; parenteral

7.4

22.2

I34.00

ICD-10 Finland

Mitral (valve) incompetence NOS or of specified cause, except rheumatic

6.3

22.0

4599X

ICD-9 Finland

Other disorders of circulatory system, Unspecified circulatory system disorder

+∞

21.9

Z31.5

ICD-10 Finland

Genetic counselling

4.3

21.6

205

Z80.3

ICD-10 Finland

Family history of malignant neoplasm of breast

8.5

21.5

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

2.4

21.4

206

958

AA1

Conventional CABG

6.0

21.4

105

JN4BD

NOMESCO Finland

Extensive body CT

2.5

21.2

177

766

R50.9

ICD-10 Finland

Fever, unspecified

2.4

21.1

204

954

ZZF00

NOMESCO Finland

Graft of adipose tissue

13.7

21.1

FN1BC

NOMESCO Finland

Extensive angiography of hear and/or coronary arteries

3.3

20.8

109

350

ZSZ10

NOMESCO Finland

Secondary repair operation

213.4

20.6

R07.4

ICD-10 Finland

Chest pain, unspecified

1.9

20.5

352

2108

N02AX02

ATC

tramadol; systemic, rectal

1.8

20.5

537

3722

QBE20

NOMESCO Finland

Excision and repair of scar or web of skin of trunk

14.5

20.4

J01MA12

ATC

levofloxacin; systemic

2.1

20.4

269

1449

Q23.11

ICD-10 Finland

Bicuspid aortic valve

11.2

20.2

PD5BD

NOMESCO Finland

Extensive CT of aorta

6.1

20.1

I25.2

ICD-10 Finland

Old myocardial infarction

2.9

20.1

129

477

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

2.5

20.0

171

749

FL1AC

NOMESCO Finland

Left cardioangiography

6.9

20.0

C50.91

ICD-10 Finland

Malignant tumor in another specified localization in ductal mammary gland

6.9

20.0

TQB05

NOMESCO Finland

Puncture of skin of trunk

13.4

19.8

WX704

NOMESCO Finland

Intubation

3.1

19.7

116

404

AC4

MVP

19.8

19.6

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

1.8

18.9

403

2589

C01BD01

ATC

amiodarone; systemic

4.4

18.8

168

HA1AT

NOMESCO Finland

Biopsy of mammary glands with ultrasound guidance

5.8

18.7

TFP00

NOMESCO Finland

Temporary use of transvenous or epicardial pacemaker

9.1

18.7

FCA60

NOMESCO Finland

Resection of aortic root and ascending aorta with reimplantation of coronary arteries and use of composite graft with mechanical valve prosthesis

24.1

18.7

J90

ICD-10 Finland

Pleural effusion, not elsewhere classified

4.2

18.7

184

I20.09

ICD-10 Finland

Unstable angina

3.1

18.5

106

364

GD1BD

NOMESCO Finland

Thorax extensive CT-examination

3.3

18.3

298

C07AB02

ATC

metoprolol; systemic

1.9

18.2

305

1797

I20.01

ICD-10 Finland

Unstable angina

4.1

18.2

179

8520/3-C50.9

ICD-O-3

Lobular carcinoma, NOS, of breast, NOS

8.0

18.1

FNC10

NOMESCO Finland

Aorto-coronary venous bypass with single distal anastomosis

6.9

18.1

T81.0

ICD-10 Finland

Haemorrhage and haematoma complicating a procedure, not elsewhere classified

3.0

18.0

109

388

L09

ICPC

Arm symptom/complaint

4.0

17.3

187

R06.0

ICD-10 Finland

Dyspnoea

1.9

17.3

323

1971

A08

ICPC

Swelling

3.5

17.3

250

I95.1

ICD-10 Finland

Orthostatic hypotension

7.3

17.2

AB2

AVR bio, stent

8.4

17.0

C50.49

ICD-10 Finland

Malignant tumor of the upper outer quadrant of the mammary gland, other or undeterminated histology

6.5

17.0

I20.99

ICD-10 Finland

Angina pectoris, unspecified

2.7

16.7

118

463

K78

ICPC

Atrial fibrillation/flutter

2.6

16.5

126

517

R4110

NOMESCO Finland

Physiotherapy

1.8

16.4

343

2170

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

1.7

16.4

460

3191

I33.0

ICD-10 Finland

Acute and subacute infective endocarditis

11.4

16.3

ZXE10

NOMESCO Finland

More than one and less than three hours

1.7

16.1

458

3180

ZZQ10

NOMESCO Finland

Free microvascular graft of skin and muscle

24.8

16.0

HA3AT

NOMESCO Finland

Pucture of mammary gland cyst with ultrasound examination

15.9

15.7

AB1

AVR mechanical

17.5

15.6

Z95.0

ICD-10 Finland

Presence of electronic cardiac devices

3.1

15.6

310

8500/3-C50.4

ICD-O-3

Infiltrating duct carcinoma, NOS, of upper-outer quadrant of breast

4.9

15.6

108

XF402

NOMESCO Finland

ECG with work load test

2.3

15.5

161

772

N02BE01

ATC

paracetamol; systemic, rectal

1.9

15.4

1003

8785

C01AA05

ATC

digoxin; systemic

2.4

15.4

136

604

PD1BD

NOMESCO Finland

Extensive CT of abdominal aorta and branches

8.4

15.3

Z42.1

ICD-10 Finland

Follow-up care involving plastic surgery of breast

12.6

14.9

C50.21

ICD-10 Finland

Malignant tumor of the upper inner quadrant of the mammary gland,ductal tumor

5.2

14.8

C50.82

ICD-10 Finland

Overall malignant tumor of the mammary gland, lobular tumor

10.6

14.7

FCA50

NOMESCO Finland

Resection and reconstruction of ascending aorta using tube graft

13.4

14.7

Catheterization and pressure measurement of the right side of the heart

18.6

14.7

FEC00

NOMESCO Finland

Pericardiopleurostomy

+∞

14.6

I50.1

ICD-10 Finland

Left ventricular failure

3.1

14.6

276

I30.9

ICD-10 Finland

Acute pericarditis, unspecified

14.4

14.6

ZZR10

NOMESCO Finland

Flap of skin and muscle

11.0

14.5

C01DA08

ATC

isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal

1.8

14.5

315

2004

PJW20

NOMESCO Finland

Lymphovenous shunt

151.7

14.5

WX892

NOMESCO Finland

Monitored bed care

2.5

14.4

114

477

K84

ICPC

Heart disease other

4.5

14.4

118

SPAT1263

SPAT

Sampling

1.6

14.3

494

3589

I34.01

ICD-10 Finland

Mitral (valve) regurgitation NOS or of specified cause, except rheumatic

11.5

14.3

SPAT1148

SPAT

Treatment of chronic ulcer or burn

2.0

14.2

184

974

TQW11

NOMESCO Finland

Vacuum treatment of wound

5.4

14.1

L02BG03

ATC

anastrozole; oral

5.9

14.1

I85.9

ICD-10 Finland

Oesophageal varices without bleeding

12.1

14.1

Z95.8

ICD-10 Finland

Presence of other cardiac and vascular implants and grafts

14.6

14.1

XF404

NOMESCO Finland

Ambulatory ECG

2.3

14.0

135

624

C03EB01

ATC

furosemide and potassium-sparing agents; systemic

3.2

14.0

246

AA1AD

NOMESCO Finland

CT of head and brain

1.8

14.0

312

1998

SPAT1253

SPAT

Initiation, adjustment, discontinuation or repetition of medication

1.7

13.9

365

2455

201

Kela drug reimbursment

Chronic cardiac insufficiency

2.8

13.9

328

XX3DW

NOMESCO Finland

Time consuming IT work

2.2

13.8

143

683

XFE00

NOMESCO Finland

Epicardial ultrasonography

4.3

13.8

123

J01FF01

ATC

clindamycin; systemic

1.7

13.8

323

2097

FC1AC

NOMESCO Finland

Angiography of thoracal aortta

9.8

13.7

A41.0

ICD-10 Finland

Sepsis due to Staphylococcus aureus

5.2

13.7

Z01.8

ICD-10 Finland

Other specified special examinations

1.8

13.6

259

1572

I98.2

ICD-10 Finland

Oesophageal varices without bleeding in diseases classified elsewhere

+∞

13.6

C50.11

ICD-10 Finland

Malignant tumor of the central part of the mammary gland,ductal tumor

5.7

13.5

207

Kela drug reimbursment

Chronic arrhythmias

1.9

13.5

208

1174

N18.9

ICD-10 Finland

Chronic kidney disease, unspecified

2.7

13.3

370

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

1.7

13.0

354

2396

111

Conventional CABG

8.2

12.8

J01CE08

ATC

benzathine benzylpenicillin; parenteral

7.6

12.7

WZC30

NOMESCO Finland

Teaching

2.0

12.6

174

938

XF640

NOMESCO Finland

3.4

12.6

181

PD5AD

NOMESCO Finland

CT of aorta

5.8

12.6

45891

ICD-8 Finland

Other disease of circulatory system, Haemorrhagia subcutanea NUD

+∞

12.5

C50.4

ICD-10 Finland

Malignant neoplasm: Upper-outer quadrant of breast

7.4

12.5

FB1BD

NOMESCO Finland

Extensive CT examination of arteria pulmonalis

2.3

12.4

117

533

ZXE04

NOMESCO Finland

Procedure duration 30 to 39 minutes

2.6

12.3

384

I35.9

ICD-10 Finland

Aortic valve disorder, unspecified

11.8

12.3

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

1.9

12.2

210

1232

C50.51

ICD-10 Finland

Malignant tumor of the lower outer quadrant of the mammary gland, ductal tumor

5.3

12.2

Z85.3

ICD-10 Finland

Personal history of malignant neoplasm of breast

7.3

12.0

R60.0

ICD-10 Finland

Localized oedema

2.0

12.0

152

793

E11.7

ICD-10 Finland

Type 2 diabetes mellitus, with multiple complications

2.7

12.0

333

QBB10

NOMESCO Finland

Major dressing of wound of skin of trunk

3.3

11.9

189

I25.0

ICD-10 Finland

Atherosclerotic cardiovascular disease, so described

2.5

11.9

400

I71.00

ICD-10 Finland

Dissecting aneurysm of aorta (ruptured) [any part]

14.8

11.8

FM1FN

NOMESCO Finland

Heart function isotope examination

16.6

11.7

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

2.2

11.6

117

552

AA2

Off pump CABG sternotomy

9.4

11.5

XX1AT

NOMESCO Finland

Other puncture with ultrasound guidance

6.8

11.5

C50.10

ICD-10 Finland

Malignant tumor of the central part of the mammary gland, no histological veryfication

13.8

11.5

SPAT1144

SPAT

Treatment of reopened or infected surgical wound

2.3

11.4

108

493

PJD42

NOMESCO Finland

Excision of axillary lymph nodes

6.4

11.4

XF400

NOMESCO Finland

ECG with 12 standard connections

1.8

11.3

217

1315

QC9S1

NOMESCO Finland

Photography of skin or subcutaneous tissue in upper extremities, unspecified

35.4

11.3

S18

ICPC

Laceration/cut

1.5

11.3

481

3624

XX1XN

NOMESCO Finland

Other isotope examination

7.4

11.3

D05.1

ICD-10 Finland

Intraductal carcinoma in situ

4.8

11.2

JCA22

NOMESCO Finland

Endoscopic ligature of oesophageal varices

17.2

11.2

GA1AE

NOMESCO Finland

Ultrasound examination of thorax

4.2

11.2

FN1CC

NOMESCO Finland

Very extensive angiography of heart and/or coronary arteries

5.0

11.2

D70.82

ICD-10 Finland

Drug-induced neutropenia

5.0

11.2

QBJ00

NOMESCO Finland

Liposuction in trunk

12.8

11.1

FKD00

NOMESCO Finland

Replacement of mitral valve using mechanical prosthesis

25.3

11.1

FWW96

NOMESCO Finland

Other reoperation on heart or major thoracic vessels

20.2

11.1

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

1.8

11.0

207

1247

HAD99

NOMESCO Finland

Other plastic operation on breast

9.3

11.0

HA1DG

NOMESCO Finland

Very extensive MRI examination of mammary gland with high intensity magnet

6.7

11.0

A02BC01

ATC

omeprazole; systemic

1.6

11.0

333

2304

C50.42

ICD-10 Finland

Malignant tumor of the upper outer quadrant of the mammary gland, lobular tumor

4.7

11.0

AJ1

Reconstruction of the aortic base, eg composite graft, incl. valve saving operation

43.7

10.9

I36.1

ICD-10 Finland

Nonrheumatic tricuspid (valve) insufficiency

5.8

10.9

SPAT1153

SPAT

Removal of sutures

1.6

10.9

381

2730

SPAT1229

SPAT

Assessment of need for aid

2.2

10.8

114

550

C50.20

ICD-10 Finland

Malignant tumor of the upper inner quadrant of the mammary gland,no histological veryfication

10.7

10.8

I31.8

ICD-10 Finland

Other specified diseases of pericardium

28.3

10.7

TFC00

NOMESCO Finland

Catheterisation of right atrium or ventricle

4.9

10.7

HWA00

NOMESCO Finland

Repair of wound dehiscence in surgery of mammary gland

21.7

10.7

AJ2

Reconstruction of the ascending aorta

21.7

10.7

N03AX16

ATC

pregabalin; oral

1.7

10.7

272

1793

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

1.5

10.5

500

3846

B01AC04

ATC

clopidogrel; oral

1.8

10.3

204

1246

J01MA02

ATC

ciprofloxacin; systemic

1.5

10.3

443

3327

HA1CM

NOMESCO Finland

Mammary gland extensive MRI examination with 3 Tesla magnet

23.6

10.2

GD1AD

NOMESCO Finland

Thorax CT examination

2.9

10.2

227

FN1BB

NOMESCO Finland

Contrast angiography of heart and/or coronary arteries after bypass surgery

6.3

10.2

QXB99

NOMESCO Finland

Other procedure to treat skin wound, unspecified location

4.9

10.1

XFP20

NOMESCO Finland

Check up of cardiac pacemaker

2.3

10.1

427

A02BC05

ATC

esomeprazole; systemic

1.5

10.0

464

3532

SPAT1097

SPAT

Recording of ECG

1.8

10.0

187

1122

JN4AD

NOMESCO Finland

Body CT examination

2.2

10.0

108

525

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

1.5

10.0

378

2747

ZXE02

NOMESCO Finland

Procedure duration 10 to 19 minutes

2.7

10.0

257

FCA70

NOMESCO Finland

Resection of aortic root and ascending aorta with reimplantation of coronary arteries and use of biological valve prosthesis and tube graft

16.8

9.9

YG1AD

NOMESCO Finland

CT examination of thorax for dose design of radiotherapy

4.5

9.9

WX720

NOMESCO Finland

Own respiration

3.0

9.8

199

ZXD10

NOMESCO Finland

Scheduled procedure

1.5

9.8

445

3369

B01AC06

ATC

acetylsalicylic acid; oral (platelet aggregation inhibitors excl. heparin)

2.9

9.8

206

A04AA01

ATC

ondansetron; systemic, rectal

2.4

9.8

375

PC1BD

NOMESCO Finland

Extensive CT of thoracic aorta

9.6

9.8

J01CA04

ATC

amoxicillin; systemic

1.5

9.7

877

7681

C10AA05

ATC

atorvastatin; oral

1.5

9.5

450

3432

PD5CG

NOMESCO Finland

Extensive MRI examination of thoracal and abdominal aortta with high intensity magnet

15.2

9.5

SPAT1262

SPAT

Handing over of treatment supplies

1.7

9.5

215

1367

J18.9

ICD-10 Finland

Pneumonia, unspecified

1.6

9.4

290

2000

Aortic Valve Replacement (AVR)

30.2

9.4

B01AB10

ATC

tinzaparin; parenteral

2.2

9.4

428

I95.9

ICD-10 Finland

Hypotension, unspecified

12.4

9.4

WZC20

NOMESCO Finland

Multidisciplinary treatment meeting

2.5

9.3

298

ZSH00

NOMESCO Finland

Procedure related to previous procedure classified in chapter H

13.8

9.2

C50.80

ICD-10 Finland

Overall malignant tumor of the mammary gland, no histological veryfication

13.8

9.2

ZXA05

NOMESCO Finland

Left side

1.6

9.2

310

2188

WZB00

NOMESCO Finland

Telephone receipt or other advice

1.6

9.1

287

1992

K74.6

ICD-10 Finland

Other and unspecified cirrhosis of liver

5.2

9.1

R4120

NOMESCO Finland

Occupational therapy

2.3

9.1

355

C09AA05

ATC

ramipril; oral

1.6

9.0

290

2018

HAC15

NOMESCO Finland

Subcutaneous mastectomy with excision of mamilla

10.1

9.0

HAD40

NOMESCO Finland

Mastopexy

10.1

9.0

WB401

NOMESCO Finland

Simple antibody therapy of primary tumour

6.6

9.0

GA4AT

NOMESCO Finland

Cathetrisation of pleural cavity with ultrasound guidance

6.1

8.9

HAD00

NOMESCO Finland

Augmentation mammoplasty

24.2

8.9

PJ5AN

NOMESCO Finland

Localisation of sentinell lymphnode with isotope imaging

3.6

8.9

112

N05CF01

ATC

zopiclone; oral

1.5

8.9

378

2807

K99

ICPC

Cardiovascular disease other

3.1

8.9

150

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

1.7

8.9

180

1106

A11

ICPC

Chest pain NOS

2.2

8.9

447

N63

ICD-10 Finland

Unspecified lump in breast

2.5

8.8

295

I70.2

ICD-10 Finland

Atherosclerosis of arteries of extremities

1.9

8.7

120

648

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

1.7

8.7

200

1273

ZXE50

NOMESCO Finland

More than nine and less than 12 hours

4.1

8.7

SPAT1254

SPAT

Administration of medicine

1.7

8.6

171

1043

AP1

Catheterization of the left side of the heart

4.1

8.6

A06AD11

ATC

lactulose; oral

1.7

8.5

185

1159

NK6BQ

NOMESCO Finland

Whole body extensive bone SPET with low dose CT

10.1

8.5

D64.9

ICD-10 Finland

Anaemia, unspecified

1.9

8.5

129

719

ZXA00

NOMESCO Finland

Right side

1.5

8.5

322

2331

SPAT1211

SPAT

Application of soft bandage

2.0

8.4

114

611

QX2XE

NOMESCO Finland

Ultrsound examination of soft tissue not elsewhere classified

3.0

8.4

156

K76

ICPC

Ischaemic heart dis without angina

3.1

8.4

145

FEC01

NOMESCO Finland

Thoracoscopic pericardiopleurostomy

+∞

8.3

C10AA01

ATC

simvastatin; oral

1.4

8.3

513

4097

FNC40

NOMESCO Finland

Aorto-coronary venous bypass with four distal anastomoses

6.3

8.3

FNE20

NOMESCO Finland

Coronary bypass using free arterial graft of radial artery

8.6

8.3

ZXE03

NOMESCO Finland

Procedure duration 20 to 29 minutes

2.3

8.3

359

FKC50

NOMESCO Finland

Repair of mitral valve for insufficiency using prosthetic chord

10.8

8.3

HAE00

NOMESCO Finland

Reconstruction of breast using prosthesis

10.8

8.3

Z95.4

ICD-10 Finland

Presence of other heart-valve replacement

9.5

8.3

SPAT1301

SPAT

No procedures

1.5

8.3

356

2647

C50.00

ICD-10 Finland

Malignant tumor of nipple and areola, no histological veryfication

6.5

8.2

M10.9

ICD-10 Finland

Gout, unspecified

2.2

8.1

403

X21

ICPC

Breast sympt/compl female other

4.4

8.1

Z50.0

ICD-10 Finland

Cardiac rehabilitation

4.7

8.1

C07AA07

ATC

sotalol; systemic

2.6

8.1

237

QB2S1

NOMESCO Finland

Photography of skin or subcutaneous tissue in chest

8.2

8.1

PD1AD

NOMESCO Finland

CT of abdominal aorta and branches

11.8

8.1

8500/3-C50.8

ICD-O-3

Infiltrating duct carcinoma, NOS, of overlapping lesion of breast

11.8

8.1

TFC20

NOMESCO Finland

Catheterisation of both sides of heart

17.3

8.1

A10AB05

ATC

insulin aspart; parenteral (insulins and analog. for injection, fast-acting)

2.1

8.1

459

T81.3

ICD-10 Finland

Disruption of operation wound, not elsewhere classified

3.4

8.1

111

I21.41

ICD-10 Finland

Acute subendocardial infarction stenosed coronary artery

2.4

8.0

278

M04AA01

ATC

allopurinol; systemic

1.7

8.0

164

1012

SPAT1256

SPAT

Intramuscular and subcutaneous injection

1.4

8.0

468

3695

SPAT1310

SPAT

Counselling related to known health issue

1.5

7.9

342

2539

C77.3

ICD-10 Finland

Secondary and unspecified malignant neoplasm: Axillary and upper limb lymph nodes

13.1

7.9

ZXE00

NOMESCO Finland

One hour or less

1.4

7.9

436

3399

L12

ICPC

Hand/finger symptom/complaint

1.8

7.9

148

886

S76

ICPC

Skin infection other

2.4

7.8

286

SPAT1149

SPAT

Suture or treatment of traumatic wound

1.8

7.8

151

911

L03AA02

ATC

filgrastim; parenteral

3.3

7.8

114

PH2AE

NOMESCO Finland

Ultrasound examination of lower leg veins

1.8

7.8

131

759

J01DA01

ATC

[U] cefalexin; systemic

1.4

7.8

682

5789

N02AA05

ATC

oxycodone; systemic

1.7

7.8

172

1084

QBE30

NOMESCO Finland

Excision and repair of surgical scar in trunk

7.0

7.8

TK800

NOMESCO Finland

Hemodialysis

3.4

7.8

109

PA6DE

NOMESCO Finland

Neck artery ultrasound examination with Doppler method

2.3

7.7

310

A10AC01

ATC

insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)

2.0

7.7

482

FKC96

NOMESCO Finland

Other repair of mitral valve for insufficiency

15.1

7.7

HA1BG

NOMESCO Finland

MRI examination of mammary gland with high intensity magnet

7.5

7.7

R02

ICPC

Shortness of breath/dyspnoea

1.8

7.6

138

818

211

AVR mechanical

18.5

7.6

B29

ICPC

Lymph/immune mech sympt/complt other

8.1

7.6

FGC10

NOMESCO Finland

Annuloplasty of tricuspid valve using prosthetic ring

11.9

7.6

Mitral valve plasty

25.2

7.6

C50.89

ICD-10 Finland

Overall malignant tumor of the mammary gland, other or undeterminated histology

6.2

7.5

I34.2

ICD-10 Finland

Nonrheumatic mitral (valve) stenosis

10.1

7.5

I20.89

ICD-10 Finland

Other angina pectoris unspecified coronary artery status

2.4

7.5

268

9707

FHL

Ablation of mammae and removal of axillary lymph nodes

7.2

7.5

E11.9

ICD-10 Finland

Type 2 diabetes mellitus, without complications

1.5

7.4

270

1925

A41.9

ICD-10 Finland

Sepsis, unspecified

2.5

7.4

232

C50.31

ICD-10 Finland

Malignant tumor of the lower inner quadrant of the mammary gland, ductal tumor

5.1

7.4

N06AX16

ATC

venlafaxine; oral

1.8

7.4

129

756

SPAT1255

SPAT

Intravenous administration of medicine

2.1

7.3

388

WB123

NOMESCO Finland

Demanding adjuvant cytostatic therapy

4.4

7.3

C50.9

ICD-10 Finland

Malignant neoplasm: Breast, unspecified

8.4

7.3

WB133

NOMESCO Finland

Very demanding adjuvant cytostatic therapy

10.9

7.3

FM1DG

NOMESCO Finland

Very extensive MRI examination of heart with high intesity magnet

5.0

7.3

SPAT1312

SPAT

General health counselling

1.5

7.3

332

2485

WX110

NOMESCO Finland

Local anesthesy

1.4

7.3

706

6068

71798

ICD-8 Finland

Other nonarticular rheumatism, Other muscular rheumatism, fibrositis and myalgia

6.3

7.2

HA6AA

NOMESCO Finland

Extra corporeal mammography of operated mammary gland

2.8

7.2

156

Z3226

NOMESCO Finland

Physiotherapist

1.6

7.2

210

1424

H02AB07

ATC

prednisone; oral

1.7

7.1

159

1001

E11.8

ICD-10 Finland

Type 2 diabetes mellitus, with unspecified complications

1.8

7.1

118

680

Z95.3

ICD-10 Finland

Presence of xenogenic heart valve

6.6

7.1

WX002

NOMESCO Finland

Sedation and analgesia

1.6

7.1

222

1529

1501

Kela drug reimbursment

Palbociclib

8.0

7.1

S97

ICPC

Chronic ulcer skin

2.2

7.1

311

PJ3AT

NOMESCO Finland

Cytology of lymphnode with ultrasound guidance

4.7

7.0

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

1.5

7.0

307

2280

WX882

NOMESCO Finland

High dependency care

2.6

6.9

178

C07AG02

ATC

carvedilol; oral

2.0

6.9

420

HAD60

NOMESCO Finland

Replacement of prosthetic implant in breast

13.9

6.9

E0000UV

ATC

1.4

6.9

409

3213

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

2.0

6.9

450

Z49.1

ICD-10 Finland

Extracorporeal dialysis

4.4

6.9

103

Kela drug reimbursment

Diabetes, insulin-treated

1.5

6.8

299

2216

SAA03

NOMESCO Finland

Extended examination of mouth

1.4

6.8

379

2939

C10AX09

ATC

ezetimibe; oral

1.8

6.8

122

719

I44.2

ICD-10 Finland

Atrioventricular block, complete

2.8

6.8

144

A40.8

ICD-10 Finland

Other streptococcal sepsis

6.1

6.8

XFN00

NOMESCO Finland

Inside imaging of coronary arteries??

6.1

6.8

WX725

NOMESCO Finland

Noninvasive ventilation

2.4

6.8

238

PG1BD

NOMESCO Finland

Extensive CT angiography of tissue graft, e.g. assessment of TRAN graft

40.3

6.8

R53

ICD-10 Finland

Malaise and fatigue

1.5

6.7

218

1513

I71.9

ICD-10 Finland

Aortic aneurysm of unspecified site, without mention of rupture

3.7

6.7

C10AA03

ATC

pravastatin; oral

1.9

6.7

495

I30.0

ICD-10 Finland

Acute nonspecific idiopathic pericarditis

22.6

6.7

I20.00

ICD-10 Finland

Unstable angina

2.5

6.7

206

L04

ICPC

Chest symptom/complaint

2.2

6.6

299

Q21.10

ICD-10 Finland

Persistent ostium secundum

7.8

6.6

394

Kela drug reimbursment

Palbociclib

7.8

6.6

FXZ00

NOMESCO Finland

Off-pump cardiac operation

5.5

6.6

127

Kela drug reimbursment

Transplant complication

3.9

6.6

Z95.9

ICD-10 Finland

Presence of cardiac and vascular implant and graft, unspecified

12.3

6.6

E78.01

ICD-10 Finland

Pure hypercholesterolaemia

1.5

6.6

223

1564

J01DA09

ATC

[U] cefadroxil; inhalant, oral

1.5

6.6

274

2006

HAE05

NOMESCO Finland

Reconstruction of breast using soft tissue and prosthesis

8.7

6.6

R18

ICD-10 Finland

Ascites

3.4

6.5

SPAT1220

SPAT

Assessment of need for rehabilitation and/or rehabilitation plan

2.0

6.4

386

ZXE05

NOMESCO Finland

Procedure duration 40 to 49 minutes

2.2

6.4

298

AC1

MVR mechanical

70.2

6.4

I33.9

ICD-10 Finland

Acute endocarditis, unspecified

14.4

6.4

QBE10

NOMESCO Finland

Excision of other lesion extending through all layers of skin of trunk

2.0

6.4

418

N02AJ06

ATC

codeine and paracetamol; systemic

1.4

6.4

373

2914

NK6AQ

NOMESCO Finland

Whole body bone SPET with low dose CT

8.2

6.3

I47.2

ICD-10 Finland

Ventricular tachycardia

3.2

6.3

J15.9

ICD-10 Finland

Bacterial pneumonia, unspecified

1.8

6.3

104

599

HA2AT

NOMESCO Finland

Cytology of mammary gland with ultrasound guidance

11.1

6.3

FKC60

NOMESCO Finland

Resection and reconstruction of leaflet of mitral valve for insufficiency

11.1

6.3

R58

ICD-10 Finland

Haemorrhage, not elsewhere classified

3.9

6.3

C50.52

ICD-10 Finland

Malignant tumor of the lower outer quadrant of the mammary gland, lobular tumor

9.3

6.3

72800

ICD-8 Finland

Vertebrogenic pain syndrome, Cervicalgia

9.3

6.3

FM1CG

NOMESCO Finland

Extensive examination of hear with high intensity magnet

9.3

6.3

FFC00

NOMESCO Finland

Suture of ostium secundum type ASD

18.1

6.3

XX9AQ

NOMESCO Finland

Supplementary SPECT-CT or additional scan

18.1

6.3

FEB51

NOMESCO Finland

Thoracoscopic pericardiotomy

+∞

6.3

T81.8

ICD-10 Finland

Other complications of procedures, not elsewhere classified

3.2

6.2

AQ1

Conventional electrophysiological examination

4.8

6.2

HAD20

NOMESCO Finland

Liposuction of breast

26.8

6.2

Z40.0

ICD-10 Finland

Prophylactic surgery for risk-factors related to malignant neoplasms

26.8

6.2

I71.09

ICD-10 Finland

Aortic dissection [regardless of location]

7.1

6.2

XG410

NOMESCO Finland

Flow-volume spirometry

2.5

6.2

195

J01FA06

ATC

roxithromycin; oral

1.4

6.1

430

3459

PB1DE

NOMESCO Finland

Upper extremity arteries ultrasound examination with Doppler method

12.6

6.1

B04

ICPC

Blood symptom/complaint

8.6

6.1

WX870

NOMESCO Finland

NAME	I9_OTHOTH
CONTROL_EXCLUDE	I9_OTH
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	I9[7-9]
HD_ICD_9	4590A\|459[8-9]
HD_ICD_8	4581\|4589
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	I9[7-9]
COD_ICD_9	4590A\|459[8-9]
COD_ICD_8	4581\|4589
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Parameter	HR [95% CI]	p-value
I9_OTHOTH	2.025 [1.78, 2.3]	< 0.001
Birth year	0.993 [0.98, 1.0]	0.108

Parameter	HR [95% CI]	p-value
I9_OTHOTH	1.619 [1.46, 1.8]	< 0.001
Birth year	0.987 [0.98, 1.0]	0.007

N-year risk	Females	Males
1	0.181%	0.287%
5	1.177%	1.963%
10	2.826%	5.128%
15	5.609%	9.404%
20	9.422%	15.918%

Other other unspecified disorders of the circulatory system

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints