Tooth agenesis EXCLUDE clefts and syndromes

K11_HYPO_ONLY

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

  • not K11_CLEFT_SYNDR
518942

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 K00.00
  • Hospital discharge: ICD-10 K00.00
  • Hospital discharge: ICD-9 5200A
  • Hospital discharge: ICD-8 52000
  • Cause of death: ICD-10 K00.00
  • Cause of death: ICD-9 5200A
  • Cause of death: ICD-8 52000

3 out of 7 registries used, show all original rules.

1568

4. Check minimum number of events

None

1568

5. Include endpoints

None

1568

6. Filter based on genotype QC (FinnGen only)

1568

Control definitions (FinnGen only)

Control conditions
not K11_CLEFT_SYNDR

Extra metadata

First used in FinnGen datafreeze
DF10

Similar endpoints

List of similar endpoints to Tooth agenesis EXCLUDE clefts and syndromes based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

None

Venn diagram with a set fully inside an highlighted set Similar with less cases:

None

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 37565 21955 15575
Only index persons 32984 19326 13658
Unadjusted period prevalence (%)
Whole population 0.55 0.63 0.44
Only index persons 0.63 0.71 0.52
Median age at first event (years)
Whole population 12.21 12.26 12.09
Only index persons 12.85 12.96 12.68

-FinnGen-

Key figures

All Female Male
Number of individuals 1568 1150 418
Unadjusted period prevalence (%) 0.34 0.39 0.18
Median age at first event (years) 20.14 19.93 20.73

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1388
Matched controls
13879
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
EBB10
NOMESCO Finland
Insertion of dental implant
234.3
323.0
351
20
K00.00
ICD-10 Finland
Hypodontia
+∞
323.0
1374
*
SBB10
NOMESCO Finland
Teeth copy
6.9
216.5
695
1752
SPC20
NOMESCO Finland
Attachment of crone of tooth to implant
182.4
210.5
216
14
EBB15
NOMESCO Finland
Insertion of dental implant abutment
158.7
207.1
215
16
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
13.2
160.0
297
280
SJD00
NOMESCO Finland
Removal or reattacment of arrow in fixed orthodontisk device
6.7
149.5
439
894
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
7.8
149.1
386
656
EBB11
NOMESCO Finland
Insertion of additional dental implant in one session
154.9
145.5
152
11
SJD10
NOMESCO Finland
Attachment of arrow to fixed orthodontisk device
5.9
129.8
419
941
SAA04
NOMESCO Finland
Special inverstigation of mouth
5.7
115.4
380
859
SJD20
NOMESCO Finland
Attachment of modifiable arrow of fixed orthodontisk device
6.5
114.1
332
641
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
10.7
112.3
229
251
ECB40
NOMESCO Finland
Surgical treatment of fracture of alveolus
116.0
108.9
117
11
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prothetic work
18.7
103.5
163
98
SJC50
NOMESCO Finland
Removal of orthodontisk device with at least 7 brackets
5.2
93.9
329
778
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
3.3
93.9
894
4952
SJD40
NOMESCO Finland
Fixation of ready made palatinal or lingual arrow
5.0
93.7
345
862
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
4.9
91.8
343
868
EB1MA
NOMESCO Finland
Cephalometry with X-ray
5.0
86.4
315
772
SJB00
NOMESCO Finland
Fitting of loose orthodontic device with user information
4.5
85.4
351
972
SAA03
NOMESCO Finland
Extended examination of mouth
3.2
84.9
985
6055
SJX10
NOMESCO Finland
Short check-up visit for orthodontisk therapy
3.7
77.4
415
1440
SJC03
NOMESCO Finland
Positioning and fixed attachment of brackets, extensive
5.2
76.4
263
598
SJC10
NOMESCO Finland
Orthodontic bandage in one tooth
4.9
76.4
279
677
SJC01
NOMESCO Finland
Positioning and fixed attachment of single bracket (Bracket with fixed attachment)
4.4
71.6
294
799
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.8
69.4
695
3676
SXC05
NOMESCO Finland
Other oral or dental procedure
3.6
67.0
355
1202
K07.23
ICD-10 Finland
Deep bite
4.5
65.3
261
686
K00.09
ICD-10 Finland
Lack of teeth due to lack of dental development UNS
37.8
64.3
82
23
SJD30
NOMESCO Finland
Demanding attachment of arrow to fixed orthodontisk device
5.3
64.3
214
463
SPA20
NOMESCO Finland
Selection and insertion of implantdistans
100.5
61.4
67
7
K07.13
ICD-10 Finland
Retrognaty, mandibular
7.4
60.0
150
223
Z96.5
ICD-10 Finland
Presence of tooth-root and mandibular implants
118.8
53.2
57
5
SXB00
NOMESCO Finland
Removeal of sutres from oral mucosa
4.7
51.3
187
441
SJC02
NOMESCO Finland
Positioning and fixed attachment of brackets
4.5
51.2
198
496
SPF40
NOMESCO Finland
Removal and reattachment with cement of tooth crone or short bridge
24.1
48.4
69
30
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
11.7
46.6
88
80
SJX11
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment, restricted
3.0
45.8
310
1215
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
3.1
44.6
276
1017
SPA05
NOMESCO Finland
Guiding rail
232.3
44.2
45
*
SJX21
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment
3.3
43.5
246
848
SPA41
NOMESCO Finland
Precision impression for fixed dental prosthesis
27.9
43.2
59
22
SJC40
NOMESCO Finland
Removal of orthodontisk device with at most 6 brackets
3.3
43.0
241
823
SAC02
NOMESCO Finland
Separate planning of oral and dental treatment, demanding
4.0
42.6
183
503
EDC10
NOMESCO Finland
Sagittal osteotomy of ramus of mandible
21.6
42.1
62
30
SPC10
NOMESCO Finland
Attachment of standard crone of tooth
17.6
40.5
64
38
SPC40
NOMESCO Finland
Preparation of first or second intermediate attachment tooth for bridge
77.6
40.1
45
6
SPC08
NOMESCO Finland
Implant crown
102.9
36.9
40
*
EBA00
NOMESCO Finland
Extraction of tooth
2.1
35.9
638
4031
EMAK
NOMESCO Finland
NA
5.3
35.8
115
234
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
9.7
35.8
74
80
SJX20
NOMESCO Finland
Check-up visit for orthodontisk therapy
3.0
35.6
227
843
WZA90
NOMESCO Finland
Other doctors statement
2.2
34.9
506
2920
SJB60
NOMESCO Finland
External device grinding and adaptation
3.4
34.7
184
599
SHA02
NOMESCO Finland
Correction of physiology of bite - basic therapy visit
3.3
34.5
191
641
SXC03
NOMESCO Finland
Other oral or dental procedure
18.3
34.2
53
30
K07.14
ICD-10 Finland
Retrognaty, maxillary
10.8
33.9
66
64
SBB20
NOMESCO Finland
Tooth X-ray examination in conjunction with visit to dentist
13.4
33.1
58
45
K08.2
ICD-10 Finland
Atrophy of edentulous alveolar ridge
30.2
33.1
44
15
SPC30
NOMESCO Finland
Tooth bridge attacment with resins
174.1
32.8
34
*
SAC03
NOMESCO Finland
Separate planning of oral and dental treatment, very demanding
8.5
32.3
72
89
SJC00
NOMESCO Finland
Bracket with fixed attachment
19.8
31.9
48
25
EEC05
NOMESCO Finland
Le Fort I osteotomy
32.4
31.4
41
13
SAC01
NOMESCO Finland
Separate planning of oral and dental treatment, standard
3.1
31.1
190
682
POLI
NOMESCO Finland
NA
319.7
30.9
31
*
OIKK
NOMESCO Finland
NA
2.6
30.6
254
1103
K07.25
ICD-10 Finland
Anomalies of dental arch relationship
3.6
30.3
147
444
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.9
30.0
775
5512
SPA02
NOMESCO Finland
Preparation for dental prosthetics
13.5
29.8
52
40
SPB10
NOMESCO Finland
Production of temporary crone to tooth
25.0
28.0
39
16
EB1AD
NOMESCO Finland
Cone beam CT of teeth and jaws (one quarter)
22.8
27.9
40
18
SPA40
NOMESCO Finland
Precision impression for dental prosthesis
30.7
27.3
36
12
SAA01
NOMESCO Finland
Simple examination of mouth
2.1
27.0
1118
9266
T84.60
ICD-10 Finland
Gingivitis associated with dental implants
52.8
26.3
31
6
K07.24
ICD-10 Finland
Open bite
5.0
25.8
85
178
SHA03
NOMESCO Finland
Correction of physiology of bite - demanding therapy visit
4.7
25.5
90
203
EB1WA
NOMESCO Finland
NA
16.4
25.0
40
25
K00.01
ICD-10 Finland
Anodontia
254.5
24.7
25
*
SPB20
NOMESCO Finland
Temporary bridge between two or more teeth
43.7
24.6
30
7
SAA02
NOMESCO Finland
Basic examination of mouth
2.1
23.7
1175
10074
SAALT
NOMESCO Finland
NA
4.0
23.7
98
258
K01.0
ICD-10 Finland
Embedded teeth
4.0
22.9
96
256
EB1CI
NOMESCO Finland
Cone beam imaging of teeth and jaws (3-4 quarters)
16.8
22.8
36
22
SPF00
NOMESCO Finland
Repatation of teeth prosthesis
13.0
21.7
38
30
K07.60
ICD-10 Finland
Snapping jaw
3.1
20.5
118
404
SPA60
NOMESCO Finland
Fitting of intermediary dental prosthesis structures, 1 to 3 units
17.6
20.1
31
18
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
4.8
19.7
67
146
EFB40
NOMESCO Finland
Removal of internal or external fixation device from facial bones
19.0
18.7
28
15
OIKH
NOMESCO Finland
NA
2.4
18.6
165
730
K07.33
ICD-10 Finland
Crowding of tooth or teeth
11.6
18.5
34
30
ECB20
NOMESCO Finland
Oral alveoplasty
22.0
18.2
26
12
EEC45
NOMESCO Finland
Reconstruction of maxilla using bone graft
182.2
17.5
18
*
SJA02
NOMESCO Finland
Plan for orthodontic care
17.2
17.4
27
16
SPC01
NOMESCO Finland
Fixed dental crown
11.7
17.1
31
27
K07.11
ICD-10 Finland
Retrognathism (mandibular)(maxillary)
8.4
17.0
37
45
SPF50
NOMESCO Finland
Removal and reattachment with cement of tooth bridnge
50.7
17.0
20
*
EB1BD
NOMESCO Finland
Extensive cone beam CT of teeth and jaws (two quarters)
64.1
16.8
19
*
K07.30
ICD-10 Finland
Spacing, abnormal of tooth or teeth
2.2
16.4
184
909
WX110
NOMESCO Finland
Local anesthesy
1.7
16.2
1018
8636
EB1BA
NOMESCO Finland
Extensive intraoral X-ray examination
18.8
16.0
24
13
SPC09
NOMESCO Finland
Implant crown, demanding
86.1
15.6
17
*
T84.62
ICD-10 Finland
Osteitis associated with dental implants
23.7
15.1
21
9
ECA55
NOMESCO Finland
Complicated parodontal operation
20.3
15.1
22
11
SPA30
NOMESCO Finland
Grinding of a single crown and bridge pillar or a single post and crown
11.9
15.1
27
23
SJX00
NOMESCO Finland
Reparation of orthodontiskt device by dentist
4.9
15.1
49
103
Z01.6
ICD-10 Finland
Radiological examination, not elsewhere classified
2.2
14.7
159
773
SPF20
NOMESCO Finland
Temporary soling for filling
21.3
14.7
21
10
K00.0
ICD-10 Finland
Anodontia
+∞
14.6
14
*
SJA01
NOMESCO Finland
Estimation of need for orthodontic care
10.2
14.5
28
28
K07.10
ICD-10 Finland
Asymmetry of jaw
9.5
14.5
29
31
ECB10
NOMESCO Finland
Reconstruction of gingiva
36.4
14.5
18
5
SJB10
NOMESCO Finland
Fitting of loose orthodontic device with user information, demanding
2.9
14.4
87
308
SPA01
NOMESCO Finland
Pre-prosthetic dental procedures
30.4
13.9
18
6
ECU00
NOMESCO Finland
Removal of implant or external fixation device from alveoli
53.9
13.8
16
*
SPB30
NOMESCO Finland
Temporary partial teeth prothesis
53.9
13.8
16
*
SJA04
NOMESCO Finland
Very demanding plan for orthodontic care
14.9
13.6
22
15
SPC25
NOMESCO Finland
Other demanding attachment of crone of tooth
21.4
13.3
19
9
SHA04
NOMESCO Finland
Correction of physiology of bite - very demanding therapy visit
5.8
13.0
36
63
EB1JA
NOMESCO Finland
Double panorama tomography of teeth and jaws or similar X-ray examination
8.9
13.0
27
31
ECA70
NOMESCO Finland
Regenerative parodontal operation or gingiva and alveolus transplantation
22.8
12.9
18
8
SDA02
NOMESCO Finland
Parodonthologic therapy
1.6
12.8
490
3590
SJA03
NOMESCO Finland
Demanding plan for orthodontic care
14.2
12.8
21
15
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.5
12.8
675
5328
K07.20
ICD-10 Finland
Crossbite (anterior)(posterior)
2.9
12.6
78
281
SDA03
NOMESCO Finland
Demanding parodonthologic therapy
1.6
12.0
428
3070
EBA10
NOMESCO Finland
Surgical removal of tooth
1.7
11.9
270
1714
SPF41
NOMESCO Finland
Repair of dental crown, bridge or implant structure, standard
11.8
11.8
21
18
K03.64
ICD-10 Finland
Dental calculus supragingival
1.5
11.7
498
3721
SJF01
NOMESCO Finland
Assessment of need for orthodontic treatment
2.0
11.4
156
835
SFB30
NOMESCO Finland
Filling of tree or more surfaces of tooth reproduced outside mouth
20.2
11.1
16
8
SPA10
NOMESCO Finland
Setting attachments on tooth or implanted bracket or imblant based structures
43.7
10.9
13
*
ECA00
NOMESCO Finland
Surgical exposure of tooth
4.6
10.9
37
83
OIKAL
NOMESCO Finland
NA
2.6
10.8
82
333
SBA00
NOMESCO Finland
Microbiological examinations
4.0
10.8
42
107
SPE90
NOMESCO Finland
Other fitting and preparation of partial tooth prosthesis
7.6
10.7
24
32
EBB20
NOMESCO Finland
Transplantation of tooth
60.5
10.6
12
*
OIKKK
NOMESCO Finland
NA
6.1
10.6
28
47
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.5
10.5
413
3012
K00.21
ICD-10 Finland
Macrodontia
110.8
10.4
11
*
K07.00
ICD-10 Finland
Macrognatia (hyperplasia) of the upper jaw
32.8
10.3
13
*
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
6.5
10.0
25
39
ECW06
NOMESCO Finland
Insertion of mini-implant or miniscrew
40.4
10.0
12
*
EAB10
NOMESCO Finland
Excision and repair of frenum of lip
8.2
9.8
21
26
YNA09
NOMESCO Finland
Other excision of bone for transplantation
55.4
9.7
11
*
Z01.2
ICD-10 Finland
Dental examination
1.4
9.6
697
5737
SHA01
NOMESCO Finland
Correction of physiology of bite - simple therapy visit
1.8
9.5
163
946
K07.26
ICD-10 Finland
Anomalies of dental arch relationship
7.6
9.4
21
28
SPB15
NOMESCO Finland
Temporary dental implant crown
100.7
9.4
10
*
ZZH22
NOMESCO Finland
Graft of patients own bone, block
17.7
9.4
14
8
ECW05
NOMESCO Finland
Restricted insertion of mini-implant or miniscrew
+∞
9.4
9
*
52000
ICD-8 Finland
Disorder of tooth development and eruption, Anodontia
+∞
9.4
9
*
TEW99
NOMESCO Finland
Other minor procedure in surgery of teeth, jaws, mouth and pharynx
2.5
9.3
70
286
SPC35
NOMESCO Finland
Production and attachment of single tooth bridge
7.3
9.2
21
29
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
2.9
9.1
55
198
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
1.7
9.1
188
1159
OIKRE
NOMESCO Finland
NA
3.5
9.0
41
121
ZXA10
NOMESCO Finland
Bilateral
1.7
9.0
190
1178
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.4
9.0
798
6786
SPA45
NOMESCO Finland
Precision impression for dental prosthesis, demanding
24.2
8.9
12
5
K07.18
ICD-10 Finland
Another anomaly in the relationship between jaw and skull base
12.6
8.9
15
12
-1
NOMESCO Finland
NA
1.4
8.7
672
5557
EFB60
NOMESCO Finland
Osteoplasty of jaws or facial bones with use of osseous graft or foreign material
+∞
8.3
8
*
K01.14
ICD-10 Finland
Retained premolar with obstruction in the upper jaw
14.6
8.2
13
9
K05.30
ICD-10 Finland
Periodontitis complex
2.1
8.1
88
430
SJD50
NOMESCO Finland
Production and attachment of palatinal or lingual arrow
2.7
8.0
52
197
K07.1
ICD-10 Finland
Anomalies of jaw-cranial base relationship
13.1
7.9
13
10
Z94.0
ICD-10 Finland
Kidney transplant status
5.2
7.9
23
45
WYA10
NOMESCO Finland
First aid or other corresponding healthcare contact
1.8
7.8
131
754
Z85.8
ICD-10 Finland
Personal history of malignant neoplasms of other organs and systems
45.2
7.7
9
*
SPC31
NOMESCO Finland
Surface-retained dental bridge, reproduced outside mouth
45.2
7.7
9
*
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
1.8
7.7
125
713
K03.5
ICD-10 Finland
Ankylosis of teeth
25.1
7.6
10
*
SPF30
NOMESCO Finland
Soling for prothesis
8.9
7.5
15
17
SDA04
NOMESCO Finland
Very demanding parodonthologic therapy
1.5
7.5
247
1714
SPF42
NOMESCO Finland
Repair of dental crown, bridge or implant structure, demanding
80.5
7.4
8
*
SJE90
NOMESCO Finland
Finishing face of orthodontick therapy
4.1
7.4
27
67
K01.12
ICD-10 Finland
Retained canine with obstruction in the upper jaw
4.2
7.3
26
63
K00.9
ICD-10 Finland
Disorder of tooth development, unspecified
+∞
7.3
7
*
EBW99
NOMESCO Finland
Other operation on tooth
15.8
7.2
11
7
SPC06
NOMESCO Finland
Fixed dental bridge pontic or bridge or crown lug
30.2
7.2
9
*
SPF10
NOMESCO Finland
Demanding repatation of teeth prosthesis
8.0
7.1
15
19
SPB06
NOMESCO Finland
Production of temporary clinic-made tooth- or implant-retained crown or bridge unit
12.1
7.1
12
10
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
10.1
7.0
13
13
SDE02
NOMESCO Finland
Periodontal treatment by dental hygienist
1.4
6.8
308
2284
OIKVA
NOMESCO Finland
NA
2.0
6.8
89
470
K07.19
ICD-10 Finland
Anomalies in the relationship between jaw and skull base UNS
16.8
6.7
10
6
SPA61
NOMESCO Finland
Fitting of intermediary dental prosthesis structures, 4 to 6 units
16.8
6.7
10
6
K06.00
ICD-10 Finland
Local gingivore traction
4.3
6.7
23
54
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
4.2
6.6
23
55
WX002
NOMESCO Finland
Sedation and analgesia
1.6
6.5
154
984
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.3
6.5
55
241
137
Kela drug reimbursment
Uraemia requiring dialysis
6.2
6.5
16
26
D19
ICPC
Teeth/gum symptom/complaint
1.4
6.5
390
3049
SPC45
NOMESCO Finland
Preparation of third or later intermediate attachment tooth for bridge
70.2
6.4
7
*
ECA50
NOMESCO Finland
Parodontal operation
7.4
6.4
14
19
SCD01
NOMESCO Finland
Simple removal of tooth plaque or tartar
2.9
6.4
37
131
Z99.2
ICD-10 Finland
Dependence on renal dialysis
11.1
6.3
11
10
J01CE02
ATC
phenoxymethylpenicillin; oral
1.3
6.3
912
8158
5200A
ICD-9 Finland
Disorders of tooth development and eruption, Anodontia
+∞
6.3
6
*
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.4
6.1
368
2872
XX7LW
NOMESCO Finland
NA
12.6
6.1
10
8

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
147
992
1.53
5.33
6.7
4.7
1.5
1.5
%
0.01
135
909
359
2875
1.32
4.90
5.2
4.8
1.1
1.1
inr
0.02
115
1005
608
5231
1.26
4.73
4.2
4.0
—
—
—
0
0
10
21
4.78
4.53
1.5
3.1
—
—
—
0
0
207
1544
1.39
4.47
3.5
2.3
15.2
14.6
umol/l
0.46
193
1444
124
840
1.52
4.44
5.2
4.5
0.1
0.1
%
0.05
27
206
104
685
1.55
4.24
5.7
3.7
64.9
68.4
e9/l
0.41
74
480
119
808
1.51
4.23
5.3
4.5
0.1
0.1
%
0.13
25
178
118
816
1.48
3.86
4.9
4.2
0.5
0.5
%
0.09
22
165
706
6278
1.23
3.83
7.4
6.2
54.9
54.6
%
0.26
662
5952
125
876
1.46
3.82
5.1
4.4
0.8
0.8
%
0.02
28
224
715
6370
1.22
3.80
7.6
6.4
31.2
31.3
%
0.13
665
6017
168
1250
1.38
3.69
3.7
2.4
25.1
23.5
%
0.65
145
1102
489
4198
1.24
3.68
7.6
6.6
—
—
—
0
0
183
1383
1.37
3.66
3.6
2.3
2.5
2.5
g/l
0.02
169
1281
52
298
1.77
3.66
1.8
2.4
1.1
1.3
g/l
1.05
45
271
851
7770
1.21
3.37
7.3
6.0
81.0
80.2
u/l
0.19
794
7295
51
300
1.72
3.31
1.5
1.4
17.6
14.4
u/l
0.36
46
261
141
1039
1.39
3.30
1.8
1.6
16.7
15.8
iu/l
0.16
118
838
62
388
1.62
3.20
1.9
1.6
—
—
—
0
0
36
193
1.88
3.16
1.7
1.8
—
—
—
0
0
1075
10083
1.21
3.04
4.1
3.8
14.2
14.3
pmol/l
0.81
966
9208
59
371
1.61
3.01
2.0
1.6
101.7
95.1
u/ml
—
9
56
676
6086
1.19
2.99
8.0
6.7
8.1
8.0
%
0.46
629
5755
671
6039
1.19
2.98
7.9
6.5
2.9
2.8
%
0.50
623
5685
161
1236
1.34
2.93
2.5
2.1
345.2
384.3
nmol/l
1.89
152
1159
43
251
1.73
2.90
3.0
3.7
3.5
3.9
e9/l
0.67
43
251
660
5942
1.19
2.89
5.6
4.4
6.1
6.2
mmol/l
0.11
585
5350
43
254
1.71
2.79
3.2
3.9
49.1
54.9
%
2.08
43
254
728
6625
1.18
2.79
7.6
6.4
2.0
2.0
e9/l
1.10
663
5927
531
4704
1.19
2.76
6.0
5.4
10.6
10.3
umol/l
0.22
498
4363
430
3736
1.21
2.76
6.7
5.1
37.2
37.6
g/l
1.08
403
3488
646
5823
1.19
2.76
8.1
6.6
0.7
0.7
%
0.23
597
5487
173
1356
1.31
2.74
4.4
3.1
29.3
29.8
s
0.58
168
1324
904
8395
1.18
2.67
4.3
3.7
8.2
8.1
mm/h
0.10
860
7788
12
43
2.80
2.64
4.5
3.1
—
—
—
0
0
1205
11482
1.21
2.64
4.7
4.3
1.8
1.9
mu/l
0.66
1135
10849
114
845
1.38
2.62
2.0
1.7
6.6
7.9
u/l
1.15
92
672
54
347
1.58
2.56
18.4
11.5
—
—
—
0
0
112
836
1.37
2.48
2.0
2.1
10.0
10.6
nmol/l
0.26
94
743
515
4589
1.18
2.46
9.6
6.5
1.2
1.2
mmol/l
0.12
438
3970
31
174
1.80
2.42
1.2
1.6
—
—
—
0
0
61
410
1.51
2.39
4.2
3.0
156.2
131.5
ng/l
0.12
53
359
129
993
1.33
2.35
1.4
1.4
—
—
—
0
0
397
3478
1.19
2.29
3.6
2.6
—
—
—
0
0
714
6585
1.15
2.11
8.1
6.8
0.2
0.2
e9/l
0.26
645
5855
342
2977
1.19
2.11
3.1
2.4
54.5
57.1
u/l
0.84
318
2752
62
431
1.46
2.09
4.6
4.9
131.3
131.6
g/l
0.05
57
417
633
5796
1.15
2.06
10.0
8.4
0.0
0.0
e9/l
0.52
537
4683
47
310
1.53
2.04
3.2
5.7
—
—
—
0
0
690
6362
1.15
2.03
7.8
6.5
0.5
0.5
e9/l
0.11
607
5561
38
240
1.60
1.99
3.1
3.3
24.7
28.1
mu/l
0.18
38
222
75
547
1.39
1.96
4.3
3.7
21.4
21.4
s
0.02
66
483
689
6375
1.14
1.88
7.8
6.5
0.0
0.0
e9/l
0.35
606
5570
8
28
2.87
1.86
1.0
1.3
—
—
—
0
0
58
409
1.43
1.85
5.5
2.5
0.2
0.2
e6/l
0.03
58
393
31
190
1.64
1.84
1.5
1.3
—
—
—
0
0
1207
11617
1.17
1.84
12.0
9.3
3.9
3.9
mmol/l
0.47
1161
11195
83
624
1.35
1.82
4.4
3.8
1.2
1.2
mmol/l
0.04
71
534
14
66
2.13
1.82
2.7
1.8
—
—
—
0
0
57
791
0.71
1.79
1.6
1.5
—
—
—
0
0
226
1925
1.20
1.78
3.7
2.6
1704.0
4397.8
umol/l
0.98
210
1741
12
54
2.23
1.74
1.4
1.2
—
—
—
0
0
765
7156
1.13
1.72
9.8
8.5
3.9
3.8
e9/l
0.20
675
6203
337
2980
1.17
1.72
2.5
2.5
2.5
2.7
mg/l
1.45
292
2585
1307
12679
1.18
1.72
11.6
9.5
19.6
19.9
mg/l
0.14
989
9213
82
622
1.34
1.71
1.3
1.4
—
—
—
0
0
33
210
1.58
1.71
3.0
2.6
—
—
—
0
0
85
650
1.32
1.69
13.9
9.1
0.9
0.5
mmol/l
0.44
62
502
68
503
1.37
1.67
1.8
1.5
259.1
196.0
u/ml
0.81
35
265
870
8223
1.13
1.62
4.8
3.8
—
—
—
0
0
16
288
0.55
1.60
5.4
7.6
—
—
—
0
0
474
4317
1.14
1.60
1.6
1.5
2.1
1.7
u/ml
0.30
121
1050
19
106
1.80
1.59
1.3
1.2
—
—
—
0
0
740
6933
1.13
1.58
3.9
2.9
66.1
65.5
ug/l
0.03
699
6541
25
152
1.65
1.56
3.3
3.5
1.2
1.3
e9/l
0.07
12
92
167
1402
1.21
1.55
9.1
5.2
0.8
0.8
mmol/l
0.89
159
1333
916
8700
1.13
1.54
3.7
3.7
36.5
37.0
mmol/mol
1.22
864
8223
1201
11605
1.15
1.53
11.9
9.2
139.4
139.5
mmol/l
1.46
1154
11229
57
768
0.73
1.53
1.5
1.5
—
—
—
0
0
6
21
2.86
1.50
1.5
9.3
—
—
—
0
0
193
1648
1.19
1.50
1.3
1.3
—
—
—
0
0
15
79
1.91
1.49
1.1
1.0
22.9
17.5
u/ml
—
6
18
169
1428
1.21
1.47
3.2
2.9
337.5
592.7
ng/l
0.77
85
732
269
2368
1.16
1.46
1.8
1.6
—
—
—
0
0
343
3075
1.15
1.45
3.8
3.1
0.0
0.0
estimate
1.08
143
1188
58
771
0.74
1.44
1.4
1.5
—
—
—
0
0
119
973
1.24
1.43
3.7
3.5
0.2
0.2
g/l
0.07
110
917
206
1778
1.18
1.43
1.4
1.4
673.9
529.3
titre
0.37
33
331
9
40
2.26
1.40
1.1
1.1
—
—
—
0
0
98
788
1.26
1.37
1.7
2.1
3.9
4.1
e9/l
0.49
82
682
5
120
0.41
1.37
1.4
1.3
—
—
—
0
0
340
3059
1.14
1.37
5.1
4.3
—
—
—
0
0
14
75
1.87
1.34
1.4
1.1
—
—
—
0
0
141
1184
1.21
1.33
5.1
3.6
9.0
6.1
umol/l
0.65
126
985
74
577
1.30
1.33
1.1
1.1
0.9
1.3
u/ml
0.52
31
301
298
2666
1.14
1.30
3.1
2.9
1.0
1.0
kg/l
0.38
41
383
135
1132
1.21
1.30
1.1
1.2
—
—
—
0
0
21
129
1.64
1.30
2.9
3.5
11.1
9.5
%
0.28
13
98
25
161
1.56
1.29
7.0
4.1
—
—
—
0
0
628
5883
1.11
1.27
3.7
2.9
0.0
0.0
estimate
0.50
142
1177
229
2015
1.16
1.26
4.6
3.8
—
—
—
0
0
14
77
1.82
1.25
1.7
1.5
—
—
—
0
0
427
3920
1.12
1.24
1.8
1.8
—
—
—
0
0
20
123
1.63
1.24
2.6
4.1
—
—
—
0
0
442
4067
1.12
1.24
2.0
2.0
—
—
—
0
0
25
163
1.54
1.23
1.1
1.1
3.3
7.1
iu/ml
—
6
36
10
49
2.05
1.22
1.1
1.1
—
—
—
0
0
1184
11487
1.12
1.21
14.5
11.8
13.2
13.2
%
0.07
1155
11235
48
357
1.35
1.21
2.0
2.2
—
—
—
0
0
490
4541
1.11
1.20
1.7
1.7
—
—
—
0
0
256
2280
1.15
1.20
2.6
2.9
98.0
104.2
ug/g
0.13
202
1751
53
402
1.33
1.18
1.4
1.6
0.4
0.3
nmol/l
0.23
41
338
164
1414
1.18
1.18
13.8
7.1
1.2
1.2
mmol/l
0.51
156
1350
53
403
1.33
1.16
1.1
1.1
8.4
7.8
u/ml
0.06
21
196
10
50
2.01
1.16
1.0
1.0
—
—
—
0
0
75
598
1.27
1.16
1.1
1.1
9.6
8.2
u/ml
0.19
41
369
823
7844
1.10
1.16
4.8
3.7
420.4
493.8
e6/l
0.09
21
74
134
1137
1.19
1.16
1.5
1.4
—
—
—
0
0
1305
12749
1.14
1.15
9.1
7.8
25.5
25.6
u/l
0.04
1264
12306
678
6405
1.10
1.14
2.6
2.5
—
—
—
0
0
103
854
1.22
1.13
3.5
3.4
4.8
4.8
pmol/l
0.19
90
769
497
4626
1.11
1.12
3.3
2.7
—
—
—
0
0
59
751
0.78
1.12
2.3
2.4
—
—
—
0
0
361
3303
1.12
1.11
3.0
2.2
—
—
—
0
0
406
3740
1.11
1.11
1.6
1.5
2.0
1.9
g/l
0.16
255
2193
7
31
2.26
1.10
1.1
1.1
—
—
—
0
0
7
31
2.26
1.10
3.4
2.6
—
—
—
0
0
130
1108
1.19
1.08
1.4
1.3
134.7
288.6
u/ml
4.20
121
1030
118
997
1.20
1.08
1.6
1.4
—
—
—
0
0
48
365
1.32
1.07
1.0
1.1
0.2
0.4
u/ml
0.88
11
89
33
236
1.41
1.07
3.2
2.9
22.0
25.7
mg/l
0.31
18
146
21
137
1.54
1.05
3.5
3.5
0.2
0.2
e9/l
0.57
15
114
16
253
0.63
1.05
1.9
1.8
—
—
—
0
0
12
67
1.80
1.04
1.8
4.6
—
—
—
0
0
323
2949
1.12
1.04
1.5
1.6
—
—
—
0
0
22
146
1.51
1.03
2.2
2.2
—
—
—
0
0
266
2402
1.13
1.03
2.6
2.2
1.1
0.9
mg/l
0.49
192
1673
81
663
1.23
1.03
1.3
1.2
0.7
3.0
u/ml
3.57
38
330
7
34
2.06
1.03
1.1
1.1
—
—
—
0
0
19
122
1.56
1.02
1.1
1.0
—
—
—
0
0
623
5888
1.10
1.01
5.2
4.1
0.0
0.0
estimate
0.50
146
1217
21
139
1.52
1.00
3.5
3.5
523.4
489.8
e6/l
0.11
15
113
627
5932
1.09
0.99
3.8
3.0
0.0
0.0
estimate
0.50
143
1188
332
3044
1.11
0.99
3.3
2.7
2.4
2.4
mmol/l
0.13
293
2742
91
758
1.21
0.98
1.1
1.2
—
—
—
0
0
11
61
1.81
0.98
2.2
3.4
822.1
669.8
u/ml
0.29
11
61
32
232
1.39
0.97
1.2
1.1
—
—
—
0
0
17
108
1.58
0.96
1.0
1.3
—
—
—
0
0
1358
13336
1.13
0.95
10.3
8.3
—
—
—
0
0
135
1171
1.17
0.94
1.3
1.2
—
—
—
0
0
7
37
1.90
0.94
1.3
2.0
7.7
9.3
mmol/l
—
7
31
219
1971
1.13
0.91
1.2
1.3
18.7
22.6
iu/ml
0.46
65
555
129
1119
1.17
0.90
3.9
3.3
—
—
—
0
0
277
2530
1.11
0.89
3.4
2.2
—
—
—
0
0
6
29
2.07
0.89
1.5
1.3
—
—
—
0
0
207
1859
1.13
0.89
1.2
1.2
14.9
10.0
u/ml
0.35
77
706
11
64
1.72
0.86
1.8
1.2
—
—
—
0
0
224
2028
1.12
0.85
2.8
2.6
—
—
—
0
0
228
2067
1.12
0.85
3.4
2.6
588.7
580.8
mosm/kgh2o
0.19
203
1776
22
154
1.43
0.83
1.1
1.2
—
—
—
0
0
11
65
1.70
0.82
1.8
1.2
—
—
—
0
0
191
1719
1.13
0.81
2.3
2.3
8022.3
6361.1
u/l
0.26
66
605
32
241
1.33
0.80
1.2
1.1
—
—
—
0
0
442
4155
1.09
0.80
10.0
6.2
1.2
1.2
mmol/l
0.36
415
3836
114
992
1.16
0.79
3.2
3.0
10.0
10.3
g/l
0.68
106
918
179
1608
1.13
0.78
1.2
1.2
—
—
—
0
0
37
473
0.78
0.78
1.8
1.6
—
—
—
0
0
10
59
1.70
0.75
1.2
1.1
—
—
—
0
0
54
441
1.23
0.75
4.0
5.4
0.2
0.4
g/l
1.06
30
250
73
615
1.20
0.75
1.5
1.5
—
—
—
0
0
18
255
0.70
0.75
1.4
1.8
143.1
178.5
pmol/l
0.69
18
242
13
83
1.57
0.75
9.5
4.4
—
—
—
0
0
41
325
1.27
0.73
1.8
1.4
—
771.4
—
0
7
42
334
1.26
0.73
1.5
1.5
—
—
—
0
0
88
758
1.17
0.71
1.9
1.8
1.3
1.3
g/l
0.03
83
714
39
309
1.27
0.71
1.1
1.1
3.7
2.4
u/ml
0.28
14
125
32
247
1.30
0.70
1.7
1.4
335.0
321.6
ug/g
0.15
20
117
50
607
0.82
0.70
17.8
10.3
1.2
1.2
inr
—
8
102
5
27
1.85
0.68
17.8
19.4
0.3
0.4
umol/l
—
5
27
38
474
0.80
0.68
1.2
1.2
—
—
—
0
0
7
42
1.67
0.68
1.3
1.2
—
—
—
0
0
345
3232
1.09
0.68
3.0
2.2
—
—
—
0
0
144
1295
1.12
0.65
2.5
2.2
2.4
2.4
mmol/l
0.21
120
1116
68
579
1.18
0.64
1.1
1.1
1.5
3.8
u/ml
1.58
22
159
148
1336
1.12
0.63
1.3
1.2
98.8
150.9
iu/ml
1.65
59
503
40
324
1.24
0.62
1.8
1.6
104.0
69.2
titre
—
5
39
8
50
1.60
0.61
1.4
2.2
—
1.6
—
0
8
51
426
1.20
0.60
3.9
4.1
7.5
19.3
ug/l
0.47
36
309
0
20
0.00
0.60
0.0
1.0
—
244.2
—
0
13
0
20
0.00
0.60
0.0
1.6
—
—
—
0
0
989
9650
1.07
0.60
2.9
2.8
1.2
1.2
mmol/l
0.50
936
9128
30
236
1.28
0.60
1.9
2.5
134.5
133.5
g/l
0.12
23
189
272
2539
1.09
0.59
5.5
3.3
7.4
7.4
ph
0.06
58
464
427
4056
1.07
0.59
4.7
3.5
71.9
76.0
e6/l
0.05
279
2598
0
22
0.00
0.59
0.0
2.6
—
—
—
0
0
128
1151
1.12
0.59
1.9
1.5
—
—
—
0
0
27
210
1.29
0.58
6.7
3.5
—
—
—
0
0
6
35
1.72
0.57
1.2
3.9
—
—
—
0
0
6
35
1.72
0.57
1.2
1.3
—
—
—
0
0
15
106
1.42
0.57
9.7
3.9
—
—
—
0
0
234
2174
1.09
0.57
4.1
2.6
7.4
8.9
e6/l
0.85
212
1899
38
310
1.23
0.57
1.2
1.1
—
—
—
0
0
44
365
1.21
0.56
1.1
1.1
—
—
—
0
0
16
115
1.39
0.56
1.3
1.4
597.9
438.4
mu/l
0.42
16
110
53
450
1.18
0.54
1.1
1.1
5.7
5.8
u/ml
0.02
27
195
12
82
1.47
0.54
1.1
1.1
1553.5
1436.9
miu/ml
0.19
12
82
10
147
0.68
0.53
1.1
1.4
0.5
1.3
promille
—
10
116
16
117
1.37
0.52
1.3
1.4
71.8
74.4
%
0.31
16
112
36
296
1.22
0.51
2.2
2.4
—
—
—
0
0
106
953
1.12
0.51
4.0
3.4
1.4
1.6
ug/l
0.49
98
865
19
144
1.32
0.50
7.7
2.9
—
—
—
0
0
6
41
1.46
0.50
1.0
1.2
—
23.1
—
0
12
339
3219
1.07
0.48
4.4
3.1
37.1
56.9
e6/l
0.52
260
2395
83
738
1.13
0.48
15.3
8.0
1.2
1.3
mmol/l
0.18
78
692
127
1158
1.10
0.48
8.9
6.3
—
7.3
—
0
6
300
2838
1.07
0.48
3.6
3.5
8.2
8.7
mmol/l
0.82
267
2539
13
93
1.40
0.48
1.5
1.6
—
—
—
0
0
126
1151
1.10
0.46
1.7
1.6
353.4
327.6
mu/l
0.30
108
1033
25
200
1.25
0.46
6.2
5.3
—
—
—
0
0
14
187
0.75
0.45
1.3
1.7
—
—
—
0
0
353
3364
1.06
0.45
1.7
1.6
103.1
97.4
pmol/l
1.52
201
1869
1469
14581
1.11
0.45
16.9
13.9
261.9
263.9
e9/l
0.65
1435
14150
20
156
1.29
0.45
1.1
1.0
—
—
—
0
0
113
1030
1.10
0.44
16.8
9.0
—
—
—
0
0
10
69
1.45
0.44
1.8
2.6
—
216.7
—
0
10
35
293
1.20
0.44
6.6
3.2
—
—
—
0
0
19
240
0.79
0.42
1.6
1.7
—
—
—
0
0
5
32
1.56
0.42
1.4
1.8
—
—
—
0
0
24
194
1.24
0.42
6.6
4.5
2.3
2.1
mmol/l
0.17
13
109
23
185
1.25
0.42
1.2
1.1
1.9
2.7
u/ml
—
8
82
179
1673
1.08
0.41
3.2
2.8
4.9
4.5
e6/l
0.13
93
849
5
33
1.52
0.41
1.2
1.6
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
27
222
1.22
0.41
1.2
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
1.8
—
1397.5
—
0
8
32
379
0.84
0.40
1.2
1.2
—
—
—
0
0
83
749
1.11
0.40
1.2
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
8
61
1.31
0.39
1.1
1.1
—
—
—
0
0
5
35
1.43
0.39
3.0
2.5
29.6
33.9
umol/l
—
5
25
5
35
1.43
0.39
1.0
1.1
—
—
—
0
0
12
159
0.75
0.38
1.4
1.4
—
—
—
0
0
9
66
1.37
0.38
1.1
1.7
—
—
—
0
0
12
89
1.35
0.38
8.8
8.1
11.8
11.8
%
0.02
12
89
282
2688
1.06
0.37
2.6
2.5
18.9
33.7
ng/l
1.00
112
1079
242
2296
1.06
0.37
2.3
2.1
195.4
213.6
u/l
0.13
235
2187
125
1157
1.09
0.37
1.6
1.6
1106.2
1106.2
nmol/l
0.00
104
901
154
1438
1.08
0.37
1.6
1.5
—
—
—
0
0
9
69
1.31
0.37
1.2
1.3
—
—
—
0
0
1469
14596
1.10
0.37
16.8
13.8
88.9
88.7
fl
0.56
1450
14385
38
328
1.16
0.36
1.5
1.7
—
4.4
—
0
5
200
1889
1.07
0.36
1.6
1.4
20.9
19.8
nmol/l
0.51
180
1670
1469
14598
1.09
0.36
16.8
13.8
29.8
29.7
pg
1.19
1450
14388
5
77
0.65
0.35
1.0
1.5
1.4
1.4
nmol/l
—
5
70
5
77
0.65
0.35
1.0
1.1
132.7
218.6
iu/ml
—
5
77
9
125
0.72
0.35
1.0
1.2
—
—
—
0
0
1470
14611
1.09
0.34
17.0
13.9
134.9
135.4
g/l
0.88
1452
14404
1470
14611
1.09
0.34
16.9
13.9
6.6
6.7
e9/l
1.48
1431
14155
10
73
1.37
0.34
1.4
2.6
33.4
24.5
ug/l
—
10
63
1469
14601
1.09
0.34
16.8
13.8
4.5
4.6
e12/l
1.67
1431
14152
12
91
1.32
0.33
3.9
7.0
28.5
79.4
g/mol
1.06
12
78
12
91
1.32
0.33
1.3
1.3
—
—
—
0
0
6
90
0.67
0.32
1.0
1.3
3.4
5.4
ug/l
—
6
80
19
155
1.23
0.32
1.7
1.6
—
—
—
0
0
19
155
1.23
0.32
1.7
1.6
—
—
—
0
0
19
155
1.23
0.32
1.7
1.6
—
—
—
0
0
19
155
1.23
0.32
1.7
1.6
—
—
—
0
0
26
220
1.18
0.31
1.1
1.1
—
—
—
0
0
142
1333
1.07
0.31
1.9
1.5
—
—
—
0
0
407
3938
1.04
0.31
1.9
1.7
—
—
—
0
0
7
52
1.35
0.31
9.0
7.0
—
—
—
0
0
124
1160
1.07
0.30
1.4
1.3
—
—
—
0
0
7
54
1.30
0.30
1.0
1.3
—
—
—
0
0
10
75
1.33
0.30
3.3
3.1
—
—
—
0
0
124
1321
0.93
0.29
1.7
1.9
—
—
—
0
0
20
238
0.84
0.29
4.8
5.2
—
—
—
0
0
20
167
1.20
0.28
2.9
3.2
—
—
—
0
0
34
298
1.14
0.28
1.2
1.2
—
—
—
0
0
14
112
1.25
0.28
2.1
1.6
2.1
0.5
u/ml
—
5
38
1026
10125
1.04
0.28
3.1
2.9
5.4
5.5
mmol/l
3.90
960
9417
53
479
1.11
0.28
1.6
1.6
—
—
—
0
0
12
94
1.28
0.28
1.1
1.2
—
—
—
0
0
1033
10197
1.04
0.27
3.4
3.2
2.7
2.8
mmol/l
1.97
974
9596
138
1460
0.94
0.27
1.9
2.1
—
—
—
0
0
17
204
0.83
0.27
3.8
5.4
395.1
380.9
umol/l
0.19
17
178
33
290
1.14
0.27
1.5
1.8
—
—
—
0
0
25
215
1.16
0.26
1.2
1.2
—
—
—
0
0
13
104
1.25
0.26
1.5
1.1
—
—
—
0
0
12
95
1.26
0.26
1.1
1.2
—
—
—
0
0
79
732
1.08
0.26
6.4
3.7
—
—
—
0
0
5
74
0.67
0.26
1.6
1.1
—
—
—
0
0
122
1150
1.07
0.26
1.9
2.3
—
—
—
0
0
121
1142
1.06
0.25
9.2
6.3
1.7
1.5
mmol/l
0.39
102
920
247
2379
1.04
0.24
1.7
1.6
1.3
1.3
mmol/l
0.48
230
2111
17
142
1.20
0.24
1.2
1.2
—
—
—
0
0
13
158
0.82
0.23
1.1
1.1
—
—
—
0
0
24
209
1.15
0.22
1.0
1.2
—
—
—
0
0
60
554
1.09
0.22
2.3
2.4
0.7
0.7
ug/l
0.02
32
283
76
709
1.08
0.22
7.4
5.0
—
—
—
0
0
10
79
1.27
0.22
1.3
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
17.0
—
0
10
0
12
0.00
0.21
0.0
1.3
—
15.3
—
0
12
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
348
3571
0.97
0.21
1.8
1.8
—
—
—
0
0
5
43
1.16
0.21
1.0
1.1
—
—
—
0
0
48
441
1.09
0.20
1.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
56.3
—
0
7
184
1772
1.04
0.19
4.6
4.3
8.1
11.3
mg/mmol
0.62
129
1247
529
5191
1.03
0.19
2.2
2.1
—
—
—
0
0
19
165
1.15
0.19
2.6
2.8
17.3
17.4
%
0.03
12
87
14
118
1.19
0.19
1.9
1.8
—
—
—
0
0
20
175
1.14
0.18
2.0
2.4
—
—
—
0
0
177
1708
1.04
0.18
3.9
3.6
421.4
261.8
mg/l
0.18
125
1208
7
61
1.15
0.17
1.9
2.2
—
—
—
0
0
7
62
1.13
0.17
1.0
1.1
—
—
—
0
0
307
2996
1.03
0.17
3.9
3.0
—
—
—
0
0
1195
12023
0.97
0.17
13.9
11.7
334.6
333.7
g/l
2.63
1184
11906
148
1533
0.96
0.16
1.7
1.9
—
—
—
0
0
303
2960
1.03
0.16
4.0
3.0
0.2
0.3
e6/l
1.21
229
2161
1293
12858
1.03
0.16
12.8
10.4
40.0
40.2
%
0.39
1075
10874
10
83
1.21
0.15
1.9
1.7
—
—
—
0
0
9
81
1.11
0.15
5.1
6.8
—
—
—
0
0
69
727
0.95
0.15
1.1
1.1
—
—
—
0
0
13
150
0.87
0.14
2.1
2.5
22.7
131.9
ug/min
—
6
100
129
1244
1.04
0.14
2.2
1.8
—
—
—
0
0
11
128
0.86
0.13
7.9
11.0
0.6
0.6
mmol/l
0.17
11
121
73
696
1.05
0.13
2.4
2.3
—
—
—
0
0
11
94
1.17
0.13
1.2
1.0
—
—
—
0
0
38
355
1.07
0.12
1.2
1.1
—
11.7
—
0
25
94
904
1.04
0.12
1.6
1.6
—
—
—
0
0
26
239
1.09
0.12
1.2
1.4
1.6
5.1
u/ml
—
10
113
15
133
1.13
0.12
1.7
2.1
—
—
—
0
0
159
1632
0.97
0.11
1.7
1.8
—
—
—
0
0
15
134
1.12
0.10
1.0
1.6
—
—
—
0
0
10
115
0.87
0.10
3.5
2.0
—
—
—
0
0
36
382
0.94
0.10
1.2
1.1
—
—
—
0
0
5
45
1.11
0.09
1.4
1.9
—
—
—
0
0
1024
10183
1.02
0.09
3.3
3.1
4.6
4.6
mmol/l
0.48
971
9664
19
174
1.09
0.09
1.7
1.3
—
—
—
0
0
163
1665
0.98
0.09
1.7
1.9
—
—
—
0
0
89
862
1.03
0.09
1.3
1.3
223.1
231.3
miu/ml
0.08
40
434
318
3135
1.02
0.09
8.2
7.0
—
—
—
0
0
22
237
0.93
0.09
1.1
1.1
96.6
199.3
iu/ml
—
8
78
6
54
1.11
0.09
4.0
5.2
—
—
—
0
0
6
54
1.11
0.09
2.0
2.6
—
—
—
0
0
100
973
1.03
0.08
1.3
1.3
—
—
—
0
0
6
72
0.83
0.07
8.5
3.5
—
—
—
0
0
163
1660
0.98
0.07
1.7
1.8
—
—
—
0
0
264
2675
0.98
0.07
2.9
2.9
—
—
—
0
0
125
1277
0.98
0.07
1.5
1.4
—
—
—
0
0
68
701
0.97
0.07
6.6
4.9
23.9
24.4
mmol/l
1.10
68
689
45
468
0.96
0.07
4.4
2.9
5.4
6.0
umol/l
0.20
37
367
14
128
1.09
0.06
1.3
1.3
—
296.0
—
0
5
167
1643
1.02
0.06
1.6
1.5
461.2
25467551.8
pmol/l
1.59
136
1445
35
365
0.96
0.06
1.3
1.1
—
—
—
0
0
35
365
0.96
0.06
1.3
1.1
—
—
—
0
0
32
306
1.05
0.05
2.3
2.3
9.1
11.4
e6/l
0.18
25
235
32
307
1.04
0.05
2.3
2.3
704.4
165.8
e6/l
0.59
25
247
41
423
0.97
0.04
1.9
2.0
9.0
6.6
ug/l
0.44
36
365
163
1649
0.99
0.04
1.7
1.9
—
—
—
0
0
1012
10095
1.01
0.03
3.2
3.0
1.5
1.5
mmol/l
0.07
956
9545
40
409
0.98
0.02
4.8
2.4
—
—
—
0
0
12
113
1.06
0.01
1.1
1.3
—
—
nmol/l
—
0
0
101
1018
0.99
0.01
2.6
2.2
32.1
32.1
u/l
0.00
83
859
35
357
0.98
0.01
2.5
1.9
3.0
5.2
iu/l
1.15
15
141
15
144
1.04
0.00
1.6
1.5
—
17.0
—
0
6
66
666
0.99
0.00
3.0
3.1
—
—
—
0
0
10
97
1.03
0.00
1.2
1.0
—
—
—
0
0
12
116
1.03
0.00
2.0
2.6
68.3
76.2
mmol/l
0.17
12
105
10
103
0.97
0.00
2.2
1.4
—
—
—
0
0
13
135
0.96
0.00
1.0
1.3
0.4
0.5
nmol/l
0.63
13
128
42
419
1.00
0.00
1.2
1.3
—
—
—
0
0
89
893
1.00
0.00
7.3
4.7
7.4
7.4
ph
0.46
12
73
11
112
0.98
0.00
1.5
1.4
8.7
10.2
umol/l
1.09
11
107
12
125
0.96
0.00
1.0
1.0
—
—
—
0
0
18
182
0.99
0.00
1.0
1.1
0.3
14.0
u/ml
—
5
69
10
101
0.99
0.00
1.4
1.2
—
—
—
0
0
11
114
0.96
0.00
1.4
1.2
—
—
—
0
0
11
114
0.96
0.00
1.0
1.1
—
—
—
0
0
25
245
1.02
0.00
1.5
2.2
8.9
9.4
mg/l
0.17
25
230
268
2675
1.00
0.00
6.3
4.3
90.8
93.5
%
1.36
261
2597
16
161
0.99
0.00
8.4
2.7
—
—
—
0
0
10
105
0.95
0.00
2.4
1.9
12.0
22.3
umol/l
—
10
99
10
102
0.98
0.00
1.1
2.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
7
72
0.97
0.00
1.6
1.5
0.8
1.0
g/l
—
7
72
5
52
0.96
0.00
1.8
1.3
—
—
—
0
0
5
58
0.86
0.00
1.2
1.5
—
2237.6
—
0
7
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
5
57
0.88
0.00
1.0
1.4
—
—
—
0
0
8
80
1.00
0.00
1.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
5
56
0.89
0.00
2.0
2.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
4.2
—
0
8
0
7
0.00
0.00
0.0
9.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
294.8
—
0
5
0
5
0.00
0.00
0.0
4.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
35.2
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.8
—
—
—
0
0
0
7
0.00
0.00
0.0
2.9
—
—
—
0
0
0
8
0.00
0.00
0.0
2.1
—
2278.0
—
0
8
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint K11_HYPO_ONLY and mortality.

Females

Parameter HR [95% CI] p-value
K11_HYPO_ONLY 1.193 [0.89, 1.61] 0.245
Birth year 0.992 [0.98, 1.0] 0.07

During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 17984 females with K11_HYPO_ONLY died.

Males

Parameter HR [95% CI] p-value
K11_HYPO_ONLY 0.962 [0.71, 1.31] 0.805
Birth year 0.989 [0.98, 1.0] 0.029

During the follow-up period (1.1.1998 — 31.12.2019), 57 out of 12761 males with K11_HYPO_ONLY died.

Mortality risk

Mortality risk for people of age

years, who have K11_HYPO_ONLY.

N-year risk Females Males
1 0.111% 0.2%
5 0.683% 1.062%
10 1.67% 2.862%
15 2.925% 5.365%
20 5.103% 9.419%

Relationships between endpoints

Index endpoint: K11_HYPO_ONLY – Tooth agenesis EXCLUDE clefts and syndromes

GWS hits: 12

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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