Tooth agenesis EXCLUDE clefts and syndromes

K11_HYPO_ONLY

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

  • not K11_CLEFT_SYNDR
518678

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 K00.00
  • Hospital discharge: ICD-10 K00.00
  • Hospital discharge: ICD-9 5200A
  • Hospital discharge: ICD-8 52000
  • Cause of death: ICD-10 K00.00
  • Cause of death: ICD-9 5200A
  • Cause of death: ICD-8 52000

3 out of 7 registries used, show all original rules.

1636

4. Check minimum number of events

None

1636

5. Include endpoints

None

1636

6. Filter based on genotype QC (FinnGen only)

1576

Control definitions (FinnGen only)

Control conditions
not K11_CLEFT_SYNDR

Extra metadata

First used in FinnGen datafreeze
DF10

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 37565 21955 15575
Only index persons 32984 19326 13658
Unadjusted period prevalence (%)
Whole population 0.55 0.63 0.44
Only index persons 0.63 0.71 0.52
Median age at first event (years)
Whole population 12.21 12.26 12.09
Only index persons 12.85 12.96 12.68

-FinnGen-

Key figures

All Female Male
Number of individuals 1576 1160 416
Unadjusted period prevalence (%) 0.35 0.41 0.19
Median age at first event (years) 20.77 20.52 21.45

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1636
Matched controls
16354
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
SBB10
NOMESCO Finland
Dental impressions
6.5
316.4
825
2202
SPC20
NOMESCO Finland
Implant borne crown
160.4
307.7
234
17
EBB11
NOMESCO Finland
Insertion of additional dental implant in one session
216.0
307.7
191
10
EBB10
NOMESCO Finland
Insertion of dental implant
158.5
307.7
415
35
K00.00
ICD-10 Finland
Hypodontia
+∞
307.7
1621
*
EBB15
NOMESCO Finland
Insertion of dental implant abutment
203.0
307.7
257
15
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
11.5
289.7
333
357
ECB40
NOMESCO Finland
Surgical treatment of fracture of alveolus
111.8
279.1
143
14
SJD00
NOMESCO Finland
Removal and/or reactivation of orthodontic arch wire
6.5
249.4
519
1092
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prosthodontic work
19.9
230.2
183
103
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
6.9
229.4
424
789
SJD10
NOMESCO Finland
Placement of orthodontic arch wire
5.7
206.6
490
1146
SJD20
NOMESCO Finland
Placement of modified orthodontic arch wire
6.3
198.9
395
782
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
8.0
188.0
281
412
SAA04
NOMESCO Finland
Special examination of mouth
5.3
172.1
431
1043
SJC50
NOMESCO Finland
Removal of fixed orthodontic appliance with at least 7 brackets
5.0
153.4
394
967
K00.09
ICD-10 Finland
Lack of teeth due to lack of dental development UNS
39.4
151.3
93
25
SPC08
NOMESCO Finland
Implant crown
68.2
142.4
78
12
SJD40
NOMESCO Finland
Placement of prefabricated palatal or lingual arch
4.6
140.2
401
1068
SJB00
NOMESCO Finland
Fitting of removable appliance incl. patient instructions
4.5
138.6
419
1164
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
4.8
138.6
380
978
EB1MA
NOMESCO Finland
Cephalometry with X-ray
4.8
134.3
363
922
SPA41
NOMESCO Finland
Precision impression for fixed dental prosthesis
16.5
128.4
110
71
SJD30
NOMESCO Finland
Demanding placement of orthodontic arch wire
5.7
125.8
261
527
SJC03
NOMESCO Finland
Positioning and fixed attachment of brackets, extensive
4.9
121.7
310
747
SJC10
NOMESCO Finland
Orthodontic band in one tooth
4.4
110.1
320
852
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
3.2
108.9
1073
6101
SJC01
NOMESCO Finland
Positioning and fixed attachment of single bracket (Bracket with fixed attachment)
4.1
107.2
347
1000
SPF40
NOMESCO Finland
Removal and reattachment of crown or small bridge
26.3
105.0
73
29
K07.13
ICD-10 Finland
Retrognaty, mandibular
7.2
103.4
163
249
SJX10
NOMESCO Finland
Orthodontic treatment/control appointment, short
3.4
101.1
470
1721
SXC05
NOMESCO Finland
Other oral or dental procedure
3.5
100.9
458
1652
SAA03
NOMESCO Finland
Extended examination of mouth
3.2
96.6
1178
7338
K07.23
ICD-10 Finland
Deep bite
4.2
96.4
300
836
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
10.7
94.4
105
104
SJC02
NOMESCO Finland
Positioning and fixed attachment of brackets
4.4
87.2
241
612
EDC10
NOMESCO Finland
Sagittal osteotomy of ramus of mandible
17.5
87.1
72
43
SPC10
NOMESCO Finland
Standard dental crown
16.1
82.4
71
46
SXB00
NOMESCO Finland
Removal of sutures from oral mucosa
4.4
81.1
223
563
K08.2
ICD-10 Finland
Atrophy of edentulous alveolar ridge
44.9
80.7
48
11
SPA20
NOMESCO Finland
Selection and insertion of implant abutment
147.4
79.8
84
6
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
9.1
78.1
98
114
SPA02
NOMESCO Finland
Preparation for dental prosthetics
9.4
73.7
90
101
WZC00
NOMESCO Finland
Treatment plan or consultation
2.5
72.1
883
5201
SJC00
NOMESCO Finland
Bondable bracket or other fixed attachement
21.9
71.1
53
25
SXC03
NOMESCO Finland
Other oral or dental procedure
16.7
68.7
58
36
K07.14
ICD-10 Finland
Retrognaty, maxillary
11.5
67.8
71
64
EEC05
NOMESCO Finland
Le Fort I osteotomy
24.7
67.5
48
20
T84.60
ICD-10 Finland
Gingivitis associated with dental implants
31.5
65.7
43
14
SJC40
NOMESCO Finland
Removal of fixed orthodontic appliance with at most 6 brackets
3.2
64.6
298
1061
SJX21
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment
3.2
64.0
289
1015
SJX11
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment, restricted
2.9
62.0
355
1426
SPB10
NOMESCO Finland
Manufacture of a temporary crown to tooth at the dental office
23.1
61.7
45
20
Z96.5
ICD-10 Finland
Presence of tooth-root and mandibular implants
135.2
61.3
65
5
EB1AD
NOMESCO Finland
Cone beam CT of teeth and jaws (one quarter)
24.7
57.7
41
17
SPC30
NOMESCO Finland
Surface-retained bridge
25.6
57.0
40
16
SAC03
NOMESCO Finland
Separate planning of oral and dental treatment, very demanding
7.7
56.7
81
110
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
2.8
55.9
351
1473
SAC02
NOMESCO Finland
Separate planning of oral and dental treatment, demanding
3.6
55.2
202
619
EMAK, ,
NOMESCO Finland
4.8
54.7
131
294
SPF00
NOMESCO Finland
Reparation of dental prosthesis without impressions
14.8
54.6
49
34
SJX20
NOMESCO Finland
Orthodontic treatment/control appointment
3.1
52.9
256
931
SHA02
NOMESCO Finland
Stomatognathic treatment, basic
3.1
51.8
251
913
SPA60
NOMESCO Finland
Fitting of intermediary dental prosthesis structures, 1 to 3 units
16.1
51.3
44
28
SBB20
NOMESCO Finland
Tooth X-ray examination in conjunction with visit to dentist
9.1
49.5
61
69
SJB60
NOMESCO Finland
Adjustment and grinding of removable appliance
3.1
46.4
212
743
SPA05
NOMESCO Finland
Surgical guide
126.2
46.0
49
*
SAC01
NOMESCO Finland
Separate planning of oral and dental treatment, standard
3.1
45.4
215
769
EB1WA, ,
NOMESCO Finland
13.9
45.2
42
31
WZA90
NOMESCO Finland
Other medical or dental certificate
2.1
45.1
604
3504
SPC40
NOMESCO Finland
Preparation of first or second intermediate attachment tooth for bridge
73.4
44.2
50
7
EB1CI
NOMESCO Finland
Cone beam imaging of teeth and jaws (3-4 quarters)
12.2
43.8
44
37
EBA00
NOMESCO Finland
Extraction of tooth
2.1
43.7
839
5544
K07.24
ICD-10 Finland
Open bite
4.8
43.6
102
224
EFB40
NOMESCO Finland
Removal of internal or external fixation device from facial bones
16.7
42.7
36
22
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
2.0
41.0
953
6684
ZXX02
NOMESCO Finland
Extent of procedure, 2 units
6.7
39.3
63
97
K07.33
ICD-10 Finland
Crowding of tooth or teeth
10.0
37.5
43
44
K07.25
ICD-10 Finland
Anomalies of dental arch relationship
3.1
37.5
168
580
OIKK, ,
NOMESCO Finland
2.4
36.2
284
1306
SPA30
NOMESCO Finland
Grinding of a single crown and bridge pillar or a single post and crown
9.0
33.7
42
48
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
3.7
33.7
112
320
ECB20
NOMESCO Finland
Oral alveoplasty
13.0
33.2
32
25
SPC01
NOMESCO Finland
Fixed dental crown
7.9
32.8
45
58
POLI, ,
NOMESCO Finland
119.1
32.8
35
*
SPF41
NOMESCO Finland
Repair of dental crown, bridge or implant structure, standard
9.4
31.0
37
40
SPA40
NOMESCO Finland
Precision impression for dental prosthesis
43.1
31.0
38
9
SAALT, ,
NOMESCO Finland
3.5
30.6
110
331
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
4.5
29.4
73
168
SAA01
NOMESCO Finland
Simple examination of mouth
2.1
27.8
1372
11604
SPC09
NOMESCO Finland
Implant crown, demanding
147.5
27.7
29
*
K01.0
ICD-10 Finland
Embedded teeth
3.3
27.6
111
358
SAA02
NOMESCO Finland
Basic examination of mouth
2.3
27.3
1440
12433
K07.11
ICD-10 Finland
Retrognathism (mandibular)(maxillary)
7.3
27.2
40
56
T84.62
ICD-10 Finland
Osteitis associated with dental implants
76.5
26.8
30
*
K00.01
ICD-10 Finland
Anodontia
275.3
26.8
27
*
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
7.5
26.3
38
52
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.0
26.1
118
408
SHA04
NOMESCO Finland
Stomatognathic treatment, very demanding
6.0
25.8
46
79
K07.10
ICD-10 Finland
Asymmetry of jaw
8.5
24.0
31
37
SPB20
NOMESCO Finland
Temporary bridge
25.9
24.0
33
13
K07.26
ICD-10 Finland
Anomalies of dental arch relationship
9.2
23.9
29
32
SJA01
NOMESCO Finland
Assesment of orthodontic treatment need
7.9
23.4
32
41
K07.60
ICD-10 Finland
Snapping jaw
2.6
23.3
149
618
OIKH, ,
NOMESCO Finland
2.3
22.7
194
916
EEC45
NOMESCO Finland
Reconstruction of maxilla using bone graft
74.4
19.7
22
*
K07.30
ICD-10 Finland
Spacing, abnormal of tooth or teeth
2.1
19.7
213
1102
ECA55
NOMESCO Finland
Complicated periodontal flap surgery
24.9
19.5
27
11
EB1BA
NOMESCO Finland
Extensive intraoral X-ray examination
26.4
19.1
26
10
ECB10
NOMESCO Finland
Reconstruction of gingiva
34.8
18.9
24
7
SJF01
NOMESCO Finland
Assessment of need for orthodontic treatment
2.1
18.8
192
972
SPF20
NOMESCO Finland
Temporary relining of dentures
44.5
18.3
22
5
ECA00
NOMESCO Finland
Surgical exposure of tooth
4.5
18.0
44
100
SPC25
NOMESCO Finland
Other demanding attachment of prosthodontic crown
53.1
18.0
21
*
SJB10
NOMESCO Finland
Fitting of removable appliance incl. patient instructions, demanding
2.7
17.8
99
383
ECA70
NOMESCO Finland
Regenerative periodontal surgery or gingival graft
20.3
17.8
26
13
K07.20
ICD-10 Finland
Crossbite (anterior)(posterior)
2.8
17.5
89
328
EAB10
NOMESCO Finland
Excision and repair of frenum of lip
7.8
17.4
24
31
SJA02
NOMESCO Finland
Workplan for orthodontic treatment
14.0
17.3
29
21
EB1JA
NOMESCO Finland
Double panorama tomography of teeth and jaws or similar X-ray examination
6.3
17.2
29
47
WX110
NOMESCO Finland
Infiltration anesthesia
1.7
17.2
1263
10909
SJX00
NOMESCO Finland
Reparation of orthodontic appliance by dentist
3.6
17.0
56
159
SJA04
NOMESCO Finland
Very demanding workplan for orthodontic treatment
19.5
16.9
25
13
K00.0
ICD-10 Finland
Anodontia
+∞
16.7
16
*
SPA10
NOMESCO Finland
Setting attachments on tooth or implanted bracket or imblant based structures
+∞
16.7
16
*
EB1BD
NOMESCO Finland
Extensive cone beam CT of teeth and jaws (two quarters)
35.4
16.7
21
6
Z01.6
ICD-10 Finland
Radiological examination, not elsewhere classified
2.0
16.4
191
1012
SDA02
NOMESCO Finland
Periodontal treatment, brief
1.6
16.3
649
4842
SPB30
NOMESCO Finland
Temporary partial denture
60.6
15.8
18
*
SPF50
NOMESCO Finland
Removal and reattachment of bridge
33.7
15.7
20
6
SJD50
NOMESCO Finland
Placement of prefabricated palatal or lingual arch, dentist-made
3.1
15.7
65
214
OIKKK, ,
NOMESCO Finland
5.1
15.3
32
64
Z3229
NOMESCO Finland
Other healthcare associate professional
2.2
14.8
132
632
SHA01
NOMESCO Finland
Stomatognathic treatment, simple
1.8
14.5
223
1295
Z01.2
ICD-10 Finland
Dental examination
1.5
14.4
942
7747
SPB06
NOMESCO Finland
Production of temporary clinic-made tooth- or implant-retained crown or bridge unit
11.5
14.3
26
23
ZXX04
NOMESCO Finland
Extent of procedure, 4 units
13.5
14.2
24
18
ECU00
NOMESCO Finland
Removal of implant or external fixation device from alveoli
42.9
14.1
17
*
SAE01, ,
NOMESCO Finland
5.5
14.0
27
50
SBA00
NOMESCO Finland
Microbiological examinations
3.5
13.9
47
136
SPA01
NOMESCO Finland
Pre-prosthetic dental procedures
30.3
13.9
18
6
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.5
13.7
786
6266
SDA03
NOMESCO Finland
Periodontal treatment
1.5
13.6
615
4670
K01.12
ICD-10 Finland
Retained canine with obstruction in the upper jaw
4.6
13.3
31
68
EB1S1
NOMESCO Finland
Photography of teeth
4.7
13.1
30
65
SPC35
NOMESCO Finland
Production and attachment of fibre-reinforced dental bridge
9.4
13.0
26
28
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
2.7
12.8
69
263
OIKRE, ,
NOMESCO Finland
3.3
12.8
48
149
OIKAL, ,
NOMESCO Finland
2.3
12.7
98
442
EBB20
NOMESCO Finland
Transplantation of tooth
+∞
12.5
12
*
SPE90
NOMESCO Finland
Other partial denture
9.4
12.5
25
27
K00.21
ICD-10 Finland
Macrodontia
130.9
12.4
13
*
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
1.7
12.4
240
1486
K07.00
ICD-10 Finland
Macrognatia (hyperplasia) of the upper jaw
26.9
12.0
16
6
TEW99
NOMESCO Finland
Other minor procedure in surgery of teeth, jaws, mouth and pharynx
2.4
12.0
80
338
SJA03
NOMESCO Finland
Demanding workplan for orthodontic treatment
9.3
12.0
24
26
SPF10
NOMESCO Finland
Demanding reparation of dental prosthesis
12.6
11.6
20
16
SPB15
NOMESCO Finland
Temporary dental implant crown
65.4
11.6
13
*
ZXX03
NOMESCO Finland
Extent of procedure, 3 units
9.3
11.5
23
25
WYA10
NOMESCO Finland
Emergency care or similar visit
1.9
11.5
156
869
K03.64
ICD-10 Finland
Dental calculus supragingival
1.4
10.9
689
5516
SCD01
NOMESCO Finland
Removal of biofilm and supragingival calculus, short
3.1
10.8
43
139
SFB30
NOMESCO Finland
Indirect three-surface restoration
13.0
10.6
18
14
K05.30
ICD-10 Finland
Periodontitis complex
1.9
10.6
126
672
52000
ICD-8 Finland
Disorder of tooth development and eruption, Anodontia
+∞
10.4
10
*
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.5
10.4
484
3654
EB1TW
NOMESCO Finland
3D modelling of dentition
12.1
10.3
18
15
-1, ,
NOMESCO Finland
1.4
10.3
789
6514
YNA09
NOMESCO Finland
Other excision of bone for transplantation
18.9
10.3
15
8
SPC06
NOMESCO Finland
Fixed dental bridge pontic or bridge or crown lug
18.9
10.3
15
8
OIKVA, ,
NOMESCO Finland
2.0
10.2
109
559
K07.35
ICD-10 Finland
Impacted or embedded teeth with abnormal position of such teeth or adjacent teeth
2.9
10.0
47
167
ECW06
NOMESCO Finland
Insertion of mini-implant or miniscrew
26.2
9.8
13
5
EB1CA
NOMESCO Finland
Tooth X-ray additional picture
1.8
9.6
147
850
SFA10
NOMESCO Finland
One-surface restoration
1.4
9.6
988
8534
K01.14
ICD-10 Finland
Retained premolar with obstruction in the upper jaw
11.4
9.6
17
15
ZXA10
NOMESCO Finland
Bilateral
1.6
9.4
217
1404
EBW99
NOMESCO Finland
Other operation on tooth
30.2
9.4
12
*
SPA45
NOMESCO Finland
Precision impression for dental prosthesis, demanding
30.2
9.4
12
*
ECB60
NOMESCO Finland
Reconstruction of alveolus
+∞
9.4
9
*
ECW05
NOMESCO Finland
Restricted insertion of mini-implant or miniscrew
+∞
9.4
9
*
ZZH22
NOMESCO Finland
Graft of patients own bone, block
12.4
9.4
16
13
SPB07
NOMESCO Finland
Temporary denture
21.8
9.3
13
6
Z97.2
ICD-10 Finland
Presence of dental prosthetic device (complete)(partial)
4.4
9.3
23
53
EBA10
NOMESCO Finland
Operative extraction of tooth
1.5
9.2
358
2601
SJE90
NOMESCO Finland
Orthodontic finishing
3.3
8.6
32
99
SDA04
NOMESCO Finland
Demanding periodontal treatment
1.4
8.6
404
3038
SPC31
NOMESCO Finland
Surface-retained dental bridge, reproduced outside mouth
16.4
8.6
13
8
K07.18
ICD-10 Finland
Another anomaly in the relationship between jaw and skull base
9.0
8.5
17
19
SPA47
NOMESCO Finland
Precision impression for denture
4.3
8.4
21
49
SPC11
NOMESCO Finland
Fixed implant bridge pontic or implant bridge or crown lug
+∞
8.3
8
*
K06.00
ICD-10 Finland
Local gingivore traction
2.8
8.2
41
151
YEA05
NOMESCO Finland
Excision of gingival or connective tissue for transplantation
22.1
8.0
11
5
SDE02
NOMESCO Finland
Periodontal treatment by dental hygienist
1.4
8.0
355
2638
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.4
8.0
493
3881
Z94.0
ICD-10 Finland
Kidney transplant status
3.9
8.0
23
60
K07.34
ICD-10 Finland
Rotation of tooth or teeth
13.1
7.9
13
10
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
7.8
264
1859
SPF42
NOMESCO Finland
Repair of dental crown, bridge or implant structure, demanding
45.2
7.7
9
*
R01AD58
ATC
fluticasone, combinations; nasal
1.4
7.7
421
3246
D19
ICPC
Teeth/gum symptom/complaint
1.4
7.6
514
4100
K03.5
ICD-10 Finland
Ankylosis of teeth
18.4
7.6
11
6
XX7LW, ,
NOMESCO Finland
18.4
7.6
11
6
EFB60
NOMESCO Finland
Osteoplasty of jaws or facial bones with use of osseous graft or foreign material
80.4
7.4
8
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
3.5
7.4
25
73
SDA12
NOMESCO Finland
Treatment of complicated periodontal disease
4.0
7.3
20
50
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.1
7.3
65
312
Z85.8
ICD-10 Finland
Personal history of malignant neoplasms of other organs and systems
10.9
7.3
13
12
SPC45
NOMESCO Finland
Preparation of third or later intermediate attachment tooth for bridge
+∞
7.3
7
*
OIKJA, ,
NOMESCO Finland
2.7
7.2
37
139
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
1.6
7.2
149
939
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
2.8
7.1
34
123
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
2.3
7.1
50
219
K07.1
ICD-10 Finland
Anomalies of jaw-cranial base relationship
10.1
7.0
13
13
127
Kela drug reimbursment
Transplant complication
3.1
7.0
28
91
K07.4
ICD-10 Finland
Malocclusion, unspecified
2.4
6.9
45
190
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
3.5
6.8
23
67
K05.39
ICD-10 Finland
Periodontitis UNS
4.1
6.8
18
44
SPF30
NOMESCO Finland
Relining of denture
6.7
6.8
16
24
K00.9
ICD-10 Finland
Disorder of tooth development, unspecified
40.2
6.8
8
*
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
2.0
6.7
65
324
SXC04
NOMESCO Finland
Other oral or dental procedure, extensive
22.6
6.7
9
*
EB1S1, ,
SPAT
22.6
6.7
9
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
3.0
6.7
28
94
ECA50
NOMESCO Finland
Periodontal flap surgery
6.4
6.6
16
25
K00.29
ICD-10 Finland
Other or indefinite deviation in the shape or size of the teeth
12.3
6.6
11
9
WX002
NOMESCO Finland
Sedation and analgesia
1.6
6.6
175
1170
K07.21
ICD-10 Finland
Anomalies of dental arch relationship
3.5
6.6
22
64
ECA30
NOMESCO Finland
Excision of lesion of gingiva
3.5
6.6
22
64
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
2.0
6.6
71
368
K03.30
ICD-10 Finland
Internal granuloma of pulp
8.7
6.6
13
15
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
2.1
6.4
59
288
WX725
NOMESCO Finland
Noninvasive ventilation
2.1
6.4
60
295
J01CE02
ATC
phenoxymethylpenicillin; oral
1.3
6.3
1061
9548
SDA01
NOMESCO Finland
Periodontal treatment, very brief
1.3
6.3
635
5339
ZXE20
NOMESCO Finland
More than three and less than five hours
1.6
6.3
131
826
K05.31
ICD-10 Finland
Periodontitis pronounced
1.9
6.3
74
395
K07.03
ICD-10 Finland
Micrognatia (hypoplasia) of the upper jaw
9.3
6.3
12
13
SPA61
NOMESCO Finland
Fitting of intermediary dental prosthesis structures, 4 to 6 units
9.3
6.3
12
13
HMAK, ,
NOMESCO Finland
1.6
6.3
150
978
5200A
ICD-9 Finland
Disorders of tooth development and eruption, Anodontia
+∞
6.3
6
*
EBB10, ,
SPAT
26.8
6.2
8
*
KMAK, ,
NOMESCO Finland
1.3
6.2
639
5383
Z01.9
ICD-10 Finland
Special examination, unspecified
1.9
6.2
70
368
SFA40
NOMESCO Finland
Restoration involving the entire crown of the tooth
1.5
6.2
175
1185
K03.66
ICD-10 Finland
Tooth plaque
1.5
6.2
171
1154
K01.15
ICD-10 Finland
Retained premolar with obstruction in the lower jaw
12.6
6.1
10
8
J01FF01
ATC
clindamycin; systemic
1.4
6.1
270
2000
WX408
NOMESCO Finland
General anesthesy, balanced
1.4
6.0
324
2480
G50.1
ICD-10 Finland
Atypical facial pain
3.3
6.0
22
68

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
154
1059
1.50
5.10
6.6
4.7
1.52
1.52
%
0.00
142
974
631
5484
1.24
4.33
2.9
2.6
—
—
—
0
0
217
1640
1.37
4.31
3.4
2.3
15.12
14.53
umol/l
0.51
203
1543
109
730
1.53
4.13
5.5
3.7
64.41
67.88
e9/l
0.43
78
508
894
8113
1.22
3.94
7.2
6.0
81.85
81.34
u/l
0.11
837
7633
126
879
1.47
3.93
5.1
4.5
0.12
0.11
%
0.04
33
240
178
1333
1.38
3.75
3.6
2.5
24.88
23.33
%
0.64
153
1180
41
216
1.92
3.74
1.6
1.8
—
—
—
0
0
121
847
1.46
3.72
5.3
4.6
0.07
0.11
%
0.22
27
206
740
6620
1.21
3.67
7.4
6.3
54.62
54.46
%
0.14
695
6295
750
6721
1.21
3.65
7.6
6.5
31.43
31.39
%
0.03
703
6394
193
1472
1.35
3.63
3.5
2.3
2.54
2.54
g/l
0.03
178
1364
1128
10536
1.23
3.54
4.1
3.8
14.23
14.32
pmol/l
0.63
1015
9630
10
22
4.57
3.43
1.4
3.5
—
—
—
0
0
173
1310
1.36
3.41
2.4
2.1
344.75
380.58
nmol/l
1.77
163
1230
120
854
1.44
3.40
4.9
4.2
0.50
0.57
%
0.13
32
240
561
4916
1.21
3.36
5.9
5.4
10.47
10.66
umol/l
0.12
526
4568
127
918
1.42
3.31
5.1
4.5
0.72
0.85
%
0.23
34
280
454
3907
1.22
3.24
6.5
5.2
37.31
37.61
g/l
0.60
427
3660
65
411
1.60
3.21
1.9
1.6
—
—
—
0
0
399
3399
1.23
3.13
7.0
6.3
1.07
1.08
inr
0.22
135
1144
52
313
1.68
3.12
1.8
2.4
1.07
1.26
g/l
0.96
45
283
146
1093
1.37
3.11
1.8
1.6
16.46
15.86
iu/l
0.10
121
869
45
261
1.74
3.08
3.1
3.7
3.53
3.84
e9/l
0.54
45
261
52
315
1.67
3.05
1.5
1.4
17.39
15.23
u/l
0.23
47
274
62
393
1.60
3.05
2.0
1.6
98.71
93.84
u/ml
—
10
59
1263
12002
1.23
3.03
4.7
4.3
1.78
1.89
mu/l
0.56
1189
11339
948
8778
1.19
2.98
4.2
3.7
8.17
8.21
mm/h
0.04
900
8156
45
264
1.72
2.97
3.3
3.9
49.62
54.92
%
1.87
45
264
420
3616
1.22
2.96
3.6
2.6
—
—
—
0
0
710
6418
1.19
2.94
8.0
6.8
8.11
8.02
%
0.40
662
6075
692
6245
1.19
2.91
5.6
4.4
6.14
6.18
mmol/l
0.13
616
5633
704
6368
1.18
2.87
7.9
6.6
2.93
2.82
%
0.66
658
6023
764
6978
1.18
2.73
7.6
6.5
1.98
2.04
e9/l
1.13
695
6267
117
865
1.38
2.72
2.1
2.1
9.65
10.23
nmol/l
0.28
107
790
91
645
1.43
2.69
4.3
3.8
1.23
1.23
mmol/l
0.02
78
553
120
893
1.37
2.68
2.0
1.7
6.50
7.89
u/l
1.31
96
696
545
4853
1.18
2.62
9.5
6.6
1.22
1.22
mmol/l
0.16
466
4239
182
1445
1.29
2.62
4.3
3.1
29.42
29.87
s
0.57
176
1411
676
6139
1.17
2.54
8.1
6.7
0.67
0.65
%
0.27
626
5794
42
256
1.66
2.46
3.1
3.3
26.13
27.02
mu/l
0.04
42
238
56
367
1.54
2.45
18.0
11.5
—
—
—
0
0
672
6113
1.17
2.45
10.0
8.4
0.01
0.00
e9/l
0.52
567
4936
9
28
3.23
2.30
1.0
1.3
—
—
—
0
0
12
47
2.56
2.27
4.5
3.1
—
—
—
0
0
356
3093
1.19
2.23
3.1
2.5
54.44
57.75
u/l
1.20
330
2863
751
6929
1.15
2.20
8.1
6.9
0.19
0.18
e9/l
0.48
677
6159
31
181
1.73
2.15
1.2
1.6
—
—
—
0
0
62
430
1.46
2.11
4.2
3.0
157.07
130.40
ng/l
0.13
54
376
686
6310
1.15
2.06
8.2
6.9
—
—
—
0
0
366
3210
1.18
2.05
3.8
3.2
0.00
0.00
estimate
1.08
157
1232
918
8620
1.15
2.04
4.8
3.8
—
—
—
0
0
1264
12149
1.18
2.03
11.9
9.4
3.90
3.89
mmol/l
0.42
1216
11717
12
50
2.41
2.02
2.1
3.2
24.00
61.55
u/ml
0.67
12
50
725
6703
1.15
2.01
7.8
6.6
0.53
0.53
e9/l
0.18
637
5862
65
462
1.42
1.97
4.6
5.0
131.50
131.16
g/l
0.05
60
445
131
1038
1.28
1.96
1.4
1.4
—
—
—
0
0
776
7217
1.14
1.95
3.8
2.9
65.38
65.53
ug/l
0.01
731
6811
724
6707
1.14
1.92
7.8
6.6
0.04
0.04
e9/l
0.35
638
5860
28
166
1.70
1.88
6.6
4.0
—
—
—
0
0
546
4975
1.15
1.83
3.1
2.5
72.31
69.64
nmol/l
1.49
507
4670
78
580
1.36
1.83
4.3
3.8
21.41
21.54
s
0.10
69
514
32
199
1.62
1.81
1.6
1.3
—
—
—
0
0
128
1024
1.27
1.80
3.6
3.6
0.23
0.23
g/l
0.07
119
968
1365
13241
1.18
1.79
11.5
9.5
19.54
20.04
mg/l
0.22
1036
9626
803
7519
1.13
1.76
9.8
8.5
3.85
3.81
e9/l
0.16
709
6521
16
81
1.98
1.74
1.1
1.0
22.90
17.50
u/ml
—
6
18
20
110
1.83
1.73
1.3
1.2
—
—
—
0
0
350
3103
1.16
1.71
2.5
2.5
2.45
2.67
mg/l
1.75
305
2694
1258
12138
1.16
1.71
11.9
9.3
139.40
139.54
mmol/l
1.30
1210
11755
15
75
2.01
1.69
1.4
1.5
—
—
—
0
0
34
219
1.56
1.68
3.0
2.6
—
—
—
0
0
27
164
1.66
1.68
3.4
3.5
1.29
1.27
e9/l
0.03
21
138
17
303
0.56
1.64
5.2
7.5
—
—
—
0
0
15
76
1.98
1.64
1.3
1.1
—
—
—
0
0
61
822
0.73
1.62
1.6
1.5
—
—
—
0
0
47
328
1.45
1.61
3.2
5.7
—
—
—
0
0
954
9062
1.13
1.59
3.7
3.7
36.51
37.05
mmol/mol
1.13
901
8570
1261
12192
1.15
1.57
14.3
11.9
13.78
13.72
%
0.21
1231
11955
12
57
2.11
1.55
1.4
1.2
—
—
—
0
0
665
6193
1.12
1.53
3.7
3.0
0.00
0.00
estimate
0.80
161
1276
517
4746
1.13
1.51
1.7
1.7
—
—
—
0
0
176
1489
1.20
1.51
8.9
5.3
0.81
0.82
mmol/l
1.18
167
1428
498
4563
1.13
1.50
1.5
1.5
2.06
1.86
u/ml
0.14
125
1095
233
2022
1.18
1.50
3.7
2.6
1658.98
4348.47
umol/l
1.03
217
1847
59
436
1.37
1.49
5.5
2.5
0.20
0.20
e6/l
0.01
59
420
14
72
1.95
1.48
2.7
1.9
—
—
—
0
0
60
798
0.74
1.48
1.6
1.5
—
—
—
0
0
88
692
1.29
1.46
13.6
9.1
0.96
0.53
mmol/l
0.50
64
540
216
1869
1.18
1.44
1.4
1.4
673.94
523.08
titre
0.39
33
351
21
126
1.67
1.40
1.0
1.0
—
—
—
0
0
70
537
1.32
1.40
1.8
1.5
262.52
199.62
u/ml
0.83
37
280
61
801
0.75
1.39
1.5
1.5
—
—
—
0
0
68
520
1.32
1.39
1.3
1.3
4.73
4.21
ug/l
0.12
63
492
85
671
1.28
1.38
1.3
1.4
—
—
—
0
0
5
121
0.41
1.37
1.8
1.7
—
—
—
0
0
665
6224
1.11
1.37
3.7
3.0
0.00
0.00
estimate
0.50
155
1235
276
2446
1.15
1.37
1.8
1.6
—
—
—
0
0
198
1711
1.18
1.35
1.3
1.3
—
—
—
0
0
102
826
1.25
1.35
1.7
2.1
4.91
5.65
e9/l
0.25
90
741
660
6180
1.11
1.34
5.2
4.2
0.00
0.00
estimate
0.50
160
1262
866
8230
1.11
1.33
4.8
3.7
420.43
489.72
e6/l
0.08
21
76
79
623
1.28
1.30
1.1
1.1
0.79
1.42
u/ml
0.81
34
340
139
1168
1.21
1.30
3.9
3.3
—
—
—
0
0
6
24
2.50
1.30
1.5
9.2
—
—
—
0
0
221
1936
1.16
1.28
1.2
1.2
13.47
9.83
u/ml
0.28
86
737
19
114
1.67
1.28
1.0
1.2
—
—
—
0
0
1364
13312
1.15
1.27
9.0
7.8
25.42
25.53
u/l
0.06
1322
12858
174
1497
1.18
1.27
3.2
2.9
402.62
597.01
ng/l
0.52
88
771
138
1165
1.20
1.24
1.4
1.3
134.69
288.29
u/ml
4.55
129
1083
15
85
1.77
1.23
1.8
1.5
—
—
—
0
0
457
4218
1.12
1.20
2.1
2.0
—
—
—
0
0
309
2790
1.13
1.17
3.1
2.9
1.02
1.02
kg/l
0.40
44
405
21
133
1.59
1.17
2.7
4.1
—
—
—
0
0
55
420
1.32
1.17
1.4
1.6
0.39
0.37
nmol/l
0.11
42
354
23
149
1.55
1.17
3.6
3.5
0.22
0.17
e9/l
0.73
17
124
139
1182
1.19
1.17
1.5
1.4
—
—
—
0
0
51
386
1.33
1.16
2.0
2.2
—
—
—
0
0
140
1193
1.19
1.15
1.1
1.2
—
—
—
0
0
24
158
1.53
1.14
2.2
2.3
—
—
—
0
0
107
890
1.22
1.14
3.4
3.4
4.85
4.74
pmol/l
0.43
94
801
348
3172
1.12
1.13
3.2
2.7
2.36
2.36
mmol/l
0.25
310
2883
80
646
1.25
1.12
1.1
1.1
10.18
8.22
u/ml
0.31
46
408
56
432
1.31
1.12
1.1
1.1
7.67
7.67
u/ml
0.00
23
217
23
151
1.53
1.11
3.6
3.4
508.94
491.35
e6/l
0.06
17
123
267
2398
1.14
1.11
2.5
2.8
96.06
104.13
ug/g
0.18
210
1858
884
8458
1.10
1.11
3.3
3.0
33.94
32.29
u/l
0.47
841
8095
51
389
1.32
1.11
1.0
1.1
0.15
0.40
u/ml
1.21
13
123
26
176
1.48
1.10
1.1
1.1
3.28
7.01
iu/ml
—
6
38
7
31
2.26
1.10
3.4
2.6
—
—
—
0
0
146
1255
1.18
1.10
5.2
3.6
8.83
5.99
umol/l
0.65
130
1044
61
770
0.78
1.09
2.3
2.3
—
—
—
0
0
7
32
2.19
1.08
1.1
1.1
—
—
—
0
0
236
2108
1.14
1.07
2.8
2.6
—
—
—
0
0
143
1231
1.18
1.06
1.2
1.2
—
—
—
0
0
238
2129
1.14
1.06
4.6
3.7
—
—
—
0
0
230
2053
1.14
1.05
1.2
1.3
18.44
23.60
iu/ml
0.68
68
595
1418
13913
1.14
1.05
10.2
8.4
—
—
—
0
0
12
67
1.80
1.04
1.8
4.6
—
—
—
0
0
427
3960
1.11
1.02
1.6
1.5
1.99
1.94
g/l
0.31
264
2300
10
53
1.89
1.01
1.1
1.1
—
—
—
0
0
12
68
1.77
1.00
1.8
1.2
—
—
—
0
0
441
4103
1.10
0.98
1.8
1.8
—
—
—
0
0
120
1026
1.18
0.98
1.6
1.4
—
—
—
0
0
154
1344
1.16
0.98
2.4
2.2
2.40
2.41
mmol/l
0.33
128
1161
247
2227
1.13
0.98
3.7
2.7
588.12
573.78
mosm/kgh2o
0.41
222
1921
86
713
1.22
0.97
1.3
1.2
2.19
3.39
u/ml
0.58
49
422
376
3473
1.11
0.97
3.0
2.2
—
—
—
0
0
10
54
1.86
0.96
1.0
1.0
—
—
—
0
0
85
707
1.21
0.94
8.7
5.2
82.13
64.65
ng/l
0.78
80
664
11
62
1.78
0.94
2.2
3.3
822.09
698.44
u/ml
0.23
11
62
7
37
1.90
0.94
1.1
1.1
—
—
—
0
0
700
6665
1.09
0.93
2.6
2.5
—
—
—
0
0
78
644
1.22
0.93
1.5
1.5
—
—
—
0
0
546
5144
1.09
0.93
3.3
2.7
6.01
5.96
ph
0.15
53
513
35
261
1.35
0.91
1.7
1.4
350.71
323.16
ug/g
0.37
22
124
173
1532
1.14
0.91
13.4
7.1
1.18
1.16
mmol/l
0.50
165
1466
370
3426
1.10
0.91
2.9
2.2
—
—
—
0
0
14
86
1.63
0.91
1.1
1.1
1439.00
1414.09
miu/ml
0.04
14
86
276
2519
1.11
0.90
2.6
2.2
1.07
1.00
mg/l
0.15
200
1762
470
4406
1.09
0.89
9.8
6.4
1.22
1.22
mmol/l
0.55
443
4097
33
245
1.35
0.89
3.2
2.9
21.98
25.89
mg/l
0.33
18
153
42
324
1.30
0.88
1.2
1.2
—
—
—
0
0
198
1776
1.13
0.87
2.3
2.3
7902.60
6594.03
u/l
0.20
67
630
6
30
2.00
0.87
1.5
1.3
—
—
—
0
0
11
64
1.72
0.86
1.2
1.1
—
—
—
0
0
13
80
1.63
0.84
1.6
1.9
53.75
48.76
%
—
8
59
29
214
1.36
0.82
6.3
3.4
—
—
—
0
0
32
240
1.34
0.82
1.2
1.1
—
—
—
0
0
33
250
1.33
0.80
1.2
1.1
—
—
—
0
0
44
348
1.27
0.79
1.5
1.5
—
—
—
0
0
93
796
1.18
0.79
1.1
1.2
—
—
—
0
0
58
475
1.23
0.78
3.8
5.7
0.19
0.38
g/l
1.18
33
274
288
2658
1.10
0.77
5.4
3.4
7.39
7.39
ph
0.01
65
481
23
166
1.39
0.75
1.1
1.2
—
—
—
0
0
120
1055
1.15
0.73
3.3
3.0
9.88
10.31
g/l
0.80
111
978
41
512
0.80
0.73
1.2
1.2
—
—
—
0
0
335
3123
1.09
0.73
1.5
1.6
—
—
—
0
0
373
3495
1.09
0.72
1.7
1.6
103.03
97.72
pmol/l
1.43
210
1947
11
68
1.62
0.71
1.8
1.1
—
—
—
0
0
250
2303
1.10
0.70
4.1
2.6
7.55
8.70
e6/l
0.61
231
2036
288
2671
1.09
0.70
3.4
2.2
—
—
—
0
0
189
1717
1.11
0.70
1.2
1.2
—
—
—
0
0
66
557
1.19
0.68
1.1
1.1
4.45
6.20
u/ml
—
6
80
42
338
1.25
0.68
1.8
1.4
—
771.43
—
0
7
452
4281
1.08
0.67
4.6
3.6
68.55
74.18
e6/l
0.08
295
2754
19
260
0.73
0.66
1.4
1.8
136.37
178.43
pmol/l
0.89
19
247
73
625
1.18
0.65
1.1
1.1
1.38
3.23
u/ml
2.16
40
387
1028
10022
1.07
0.64
2.9
2.9
1.21
1.18
mmol/l
0.57
974
9484
5
29
1.73
0.64
1.2
3.3
—
—
—
0
0
31
243
1.28
0.62
1.9
2.5
134.92
133.35
g/l
0.21
24
196
14
199
0.70
0.61
1.3
1.7
—
—
—
0
0
153
1386
1.11
0.61
1.3
1.2
96.47
155.11
iu/ml
2.09
62
515
0
20
0.00
0.60
0.0
1.0
—
244.15
—
0
13
1536
15226
1.14
0.60
16.8
14.0
262.40
264.20
e9/l
0.57
1500
14783
92
808
1.15
0.60
1.9
1.8
1.26
1.27
g/l
0.03
87
761
0
22
0.00
0.59
0.0
1.9
—
—
—
0
0
316
2971
1.08
0.58
3.6
3.6
8.24
8.68
mmol/l
0.68
285
2695
27
211
1.28
0.57
6.2
5.4
—
—
—
0
0
1535
15221
1.13
0.57
17.3
14.0
40.18
40.55
%
0.59
1450
14495
6
36
1.67
0.56
1.2
1.3
—
—
—
0
0
19
252
0.75
0.56
1.6
1.7
—
—
—
0
0
111
994
1.12
0.55
3.9
3.4
1.39
1.61
ug/l
0.49
102
903
6
37
1.62
0.55
1.2
3.9
—
—
—
0
0
133
1204
1.11
0.55
1.6
1.6
1088.59
1105.46
nmol/l
0.09
110
936
41
339
1.21
0.55
1.8
1.6
104.00
75.50
titre
—
5
40
14
99
1.42
0.54
8.6
8.0
11.74
11.68
%
0.03
14
99
20
151
1.33
0.54
7.4
3.2
—
—
—
0
0
56
479
1.17
0.53
1.1
1.1
4.92
5.64
u/ml
0.13
30
267
1537
15249
1.13
0.52
16.8
13.9
6.60
6.71
e9/l
1.47
1496
14776
147
1343
1.10
0.52
3.6
3.4
885.57
745.05
ng/l
0.17
111
1038
6
96
0.62
0.52
1.0
1.4
3.43
6.74
ug/l
—
6
86
38
314
1.21
0.52
2.6
2.5
—
—
—
0
0
1536
15240
1.12
0.51
16.7
13.9
88.81
88.68
fl
0.53
1516
15027
25
197
1.27
0.51
6.4
4.4
2.29
2.03
mmol/l
0.19
14
111
16
118
1.36
0.50
1.3
1.4
597.87
431.50
mu/l
0.44
16
113
1536
15243
1.12
0.50
16.7
13.9
29.76
29.68
pg
1.12
1516
15031
23
180
1.28
0.49
1.8
1.3
—
—
—
0
0
26
207
1.26
0.49
1.2
1.1
1.42
2.24
u/ml
0.23
12
100
1537
15256
1.12
0.48
16.8
14.0
134.80
135.26
g/l
0.74
1518
15047
7
46
1.52
0.48
1.3
1.2
—
—
—
0
0
1536
15246
1.12
0.48
16.7
13.9
4.55
4.57
e12/l
1.52
1496
14783
45
382
1.18
0.48
1.1
1.2
—
—
—
0
0
16
120
1.34
0.46
1.3
1.4
71.75
74.50
%
0.33
16
115
131
1200
1.10
0.46
1.7
1.6
347.48
326.07
mu/l
0.25
112
1078
20
254
0.78
0.46
4.7
5.4
—
—
—
0
0
7
49
1.43
0.46
2.7
1.9
—
—
—
0
0
13
94
1.39
0.46
1.5
1.6
—
—
—
0
0
358
3414
1.06
0.45
4.4
3.2
35.75
54.41
e6/l
0.52
274
2548
7
50
1.40
0.45
1.9
1.2
127.83
154.63
mmol/24h
—
7
50
12
86
1.40
0.44
5.3
6.6
—
—
—
0
0
87
782
1.12
0.44
1.1
1.2
—
—
—
0
0
254
2401
1.07
0.42
2.3
2.1
190.72
210.75
u/l
0.16
247
2289
13
96
1.36
0.41
9.4
4.6
—
—
—
0
0
0
15
0.00
0.41
0.0
1.8
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
56.29
—
0
7
28
231
1.22
0.41
1.1
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
11
79
1.39
0.40
3.6
3.1
—
—
—
0
0
5
34
1.47
0.40
1.4
1.8
—
17.09
—
0
11
5
34
1.47
0.40
1.4
1.8
—
—
—
0
0
0
18
0.00
0.40
0.0
2.1
—
1424.33
—
0
9
13
97
1.34
0.39
1.1
1.2
—
—
—
0
0
0
19
0.00
0.39
0.0
2.1
—
—
—
0
0
22
178
1.24
0.38
3.5
3.4
—
—
—
0
0
39
335
1.17
0.38
1.1
1.1
3.75
2.39
u/ml
0.29
14
134
5
36
1.39
0.38
1.2
1.6
—
—
—
0
0
159
1485
1.08
0.38
1.5
1.5
—
—
—
0
0
51
448
1.14
0.38
3.9
4.0
7.47
18.49
ug/l
0.46
36
325
5
37
1.35
0.37
3.2
1.4
—
—
—
0
0
5
37
1.35
0.37
3.0
2.4
29.60
33.37
umol/l
—
5
27
127
1177
1.09
0.37
1.8
2.3
—
—
—
0
0
13
169
0.77
0.37
1.5
1.4
—
—
—
0
0
26
216
1.21
0.36
1.0
1.2
—
—
—
0
0
10
135
0.74
0.36
1.1
1.2
0.26
13.27
u/ml
—
5
94
424
4090
1.05
0.36
1.9
1.7
—
—
—
0
0
1068
10514
1.04
0.36
3.1
2.9
5.40
5.52
mmol/l
3.43
999
9786
5
76
0.66
0.35
1.6
1.1
—
—
—
0
0
196
1851
1.07
0.35
4.4
4.2
7.84
11.92
mg/mmol
0.88
134
1295
39
338
1.16
0.35
1.5
1.8
—
4.00
—
0
6
9
123
0.73
0.35
1.7
1.5
351.00
447.71
pmol/l
—
9
107
9
125
0.72
0.35
1.0
1.2
—
—
—
0
0
6
43
1.40
0.35
1.0
1.2
—
22.85
—
0
13
25
297
0.84
0.34
2.1
2.1
—
—
—
0
0
102
941
1.09
0.34
10.0
7.3
105.12
105.00
mmol/l
0.09
102
941
12
91
1.32
0.33
1.2
1.3
—
—
—
0
0
13
166
0.78
0.33
1.5
1.4
1.96
2.64
g/l
—
8
124
130
1214
1.08
0.33
1.8
1.5
—
—
—
0
0
20
164
1.22
0.32
1.1
1.0
—
—
—
0
0
56
502
1.12
0.32
1.6
1.6
—
—
—
0
0
28
238
1.18
0.32
1.2
1.1
—
—
—
0
0
10
74
1.35
0.32
1.8
2.6
—
216.68
—
0
10
106
983
1.08
0.32
9.1
6.6
23.89
23.80
mmol/l
0.12
106
978
44
496
0.88
0.32
1.8
1.6
—
—
—
0
0
15
119
1.26
0.31
2.0
1.5
2.09
4.16
u/ml
—
8
66
121
1129
1.08
0.31
16.5
9.1
—
—
—
0
0
291
2793
1.05
0.31
2.6
2.5
18.58
32.86
ng/l
1.01
116
1130
7
52
1.35
0.31
9.0
7.0
—
—
—
0
0
132
1239
1.07
0.30
1.4
1.3
—
—
—
0
0
1246
12578
0.96
0.29
13.9
11.8
334.56
333.75
g/l
2.57
1235
12455
7
57
1.23
0.29
1.0
1.3
—
—
—
0
0
15
121
1.24
0.28
8.3
4.0
—
—
—
0
0
13
162
0.80
0.28
1.1
1.1
—
—
—
0
0
18
216
0.83
0.28
3.8
5.4
395.39
385.91
umol/l
0.13
18
190
95
883
1.08
0.28
2.3
2.2
10.04
20.74
au/ml
—
5
73
12
151
0.79
0.28
1.1
1.4
0.66
1.29
promille
0.98
12
118
328
3167
1.04
0.28
3.8
3.1
—
—
—
0
0
188
1790
1.06
0.28
3.8
3.6
402.42
254.74
mg/l
0.18
131
1274
8
62
1.29
0.28
1.1
1.1
—
—
—
0
0
36
318
1.13
0.27
5.8
3.1
—
—
—
0
0
79
730
1.09
0.27
2.4
2.3
—
—
—
0
0
128
1357
0.94
0.27
1.7
1.9
—
—
—
0
0
20
168
1.19
0.27
2.5
2.8
17.49
17.34
%
0.08
13
90
1073
10597
1.04
0.27
3.4
3.3
2.71
2.79
mmol/l
2.67
1020
10016
205
1960
1.05
0.26
1.6
1.4
20.81
19.82
nmol/l
0.49
183
1733
132
1246
1.06
0.26
9.2
6.4
1.63
1.49
mmol/l
0.23
109
1023
10
77
1.30
0.26
1.4
2.6
33.37
24.31
ug/l
—
10
66
188
1795
1.05
0.26
3.1
2.9
4.83
4.28
e6/l
0.16
97
924
9
73
1.23
0.25
1.1
1.7
—
—
—
0
0
13
159
0.82
0.25
1.8
2.3
22.65
127.06
ug/min
—
6
107
550
5380
1.03
0.24
2.2
2.1
—
—
—
0
0
5
38
1.32
0.23
1.0
1.1
—
—
—
0
0
11
136
0.81
0.23
7.9
11.0
0.62
0.59
mmol/l
0.17
11
129
323
3134
1.04
0.23
3.9
3.1
0.19
0.28
e6/l
1.27
246
2314
149
1420
1.05
0.23
1.9
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
17.03
—
0
10
0
11
0.00
0.21
0.0
1.7
—
4.24
—
0
11
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
15.27
—
0
12
12
98
1.23
0.21
1.1
1.2
—
—
—
0
0
5
43
1.16
0.21
1.0
1.1
—
—
—
0
0
81
760
1.07
0.21
6.3
3.7
—
—
—
0
0
361
3701
0.97
0.20
1.8
1.8
—
—
—
0
0
190
1829
1.04
0.20
3.0
2.8
1.04
1.08
e6/l
0.07
99
958
35
385
0.91
0.19
1.2
1.2
—
—
—
0
0
25
280
0.89
0.18
1.4
1.6
—
1360.00
—
0
8
13
109
1.19
0.18
1.5
1.1
—
—
—
0
0
135
1294
1.05
0.18
2.1
1.8
—
—
—
0
0
62
581
1.07
0.17
2.3
2.4
0.70
0.68
ug/l
0.05
32
298
37
403
0.92
0.17
1.2
1.1
—
—
—
0
0
7
63
1.11
0.17
1.0
1.1
—
—
—
0
0
17
148
1.15
0.16
1.2
1.2
—
—
—
0
0
34
311
1.09
0.16
1.5
1.8
—
—
—
0
0
12
101
1.19
0.16
3.9
7.9
28.50
82.68
g/mol
1.29
12
87
152
1575
0.96
0.16
1.7
1.9
—
—
—
0
0
393
4005
0.97
0.16
3.8
3.3
31.41
29.73
u/l
0.38
376
3819
85
809
1.05
0.15
7.2
5.2
—
—
—
0
0
6
78
0.77
0.15
1.0
1.5
1.72
1.40
nmol/l
—
6
71
85
810
1.05
0.15
1.3
1.2
48.40
34.89
au/ml
—
5
32
9
83
1.08
0.14
1.0
1.3
69.00
69.28
umol/l
—
9
83
49
460
1.07
0.14
1.0
1.1
—
—
—
0
0
255
2493
1.03
0.13
1.7
1.6
1.28
1.33
mmol/l
0.59
237
2217
13
113
1.15
0.13
1.0
1.0
12.57
20.45
u/ml
—
5
66
103
1069
0.96
0.13
2.6
2.2
31.86
31.97
u/l
0.01
85
901
93
893
1.04
0.13
1.3
1.3
229.66
233.15
miu/ml
0.03
42
449
41
437
0.94
0.12
1.9
1.9
8.98
6.51
ug/l
0.47
36
378
279
2845
0.98
0.12
2.9
3.0
—
—
—
0
0
34
316
1.08
0.12
1.2
1.2
—
—
—
0
0
36
384
0.94
0.11
1.2
1.1
—
—
—
0
0
36
384
0.94
0.11
1.3
1.1
—
—
—
0
0
176
1716
1.03
0.11
1.6
1.5
459.15
24355155.83
pmol/l
1.59
142
1511
67
700
0.95
0.11
2.9
3.1
—
—
—
0
0
23
250
0.92
0.11
1.7
1.8
0.51
0.76
g/l
1.00
18
201
163
1671
0.97
0.11
1.7
1.8
—
—
—
0
0
72
750
0.96
0.11
1.1
1.1
—
—
—
0
0
167
1708
0.97
0.10
1.7
1.9
—
—
—
0
0
12
135
0.89
0.10
1.0
1.0
—
—
—
0
0
1064
10580
1.02
0.10
3.3
3.1
4.58
4.62
mmol/l
0.81
1015
10072
10
114
0.88
0.09
2.2
1.4
—
—
—
0
0
19
174
1.09
0.09
1.0
1.1
0.09
3.78
u/ml
—
5
72
11
124
0.89
0.09
3.3
2.1
—
—
—
0
0
15
165
0.91
0.09
1.3
1.6
9.22
10.35
g/l
0.31
15
159
6
57
1.05
0.08
4.0
5.2
—
—
—
0
0
6
57
1.05
0.08
2.0
2.6
—
—
—
0
0
167
1703
0.98
0.08
1.7
1.8
—
—
—
0
0
5
61
0.82
0.08
1.0
1.3
—
—
—
0
0
5
65
0.77
0.08
2.0
1.7
—
—
—
0
0
34
322
1.06
0.08
2.7
2.5
8.85
11.50
e6/l
0.22
26
246
13
117
1.11
0.08
3.3
2.8
39301.69
40412.97
ug/l
0.08
13
117
11
98
1.12
0.07
1.2
1.0
—
—
—
0
0
34
323
1.05
0.07
2.7
2.5
684.85
638.35
e6/l
0.03
26
260
7
82
0.85
0.07
1.0
1.1
119.87
218.49
iu/ml
—
7
82
45
432
1.04
0.07
4.4
2.4
—
—
—
0
0
13
118
1.10
0.07
1.3
1.2
—
—
—
0
0
10
89
1.12
0.06
1.9
1.7
—
—
—
0
0
8
95
0.84
0.06
1.4
1.3
145.45
181.30
pmol/l
—
8
95
15
138
1.09
0.06
1.7
2.0
—
—
—
0
0
26
247
1.05
0.05
1.2
1.3
1.60
5.05
u/ml
—
10
117
42
435
0.96
0.05
1.2
1.3
—
—
—
0
0
15
139
1.08
0.05
1.0
1.6
—
—
—
0
0
40
386
1.04
0.05
1.2
1.3
10.29
48.85
u/ml
—
7
19
167
1691
0.99
0.05
1.7
1.8
—
—
—
0
0
1052
10488
1.01
0.04
3.2
3.1
1.46
1.46
mmol/l
0.07
1001
9946
10
109
0.92
0.04
2.4
1.9
12.00
21.87
umol/l
—
10
103
14
131
1.07
0.03
1.9
1.7
—
—
—
0
0
11
118
0.93
0.03
1.5
1.5
8.69
10.22
umol/l
1.09
11
113
36
369
0.97
0.02
2.4
1.9
3.03
5.05
iu/l
1.06
15
147
12
113
1.06
0.01
1.1
1.3
—
—
nmol/l
—
0
0
150
1510
0.99
0.01
1.8
2.1
—
—
—
0
0
39
382
1.02
0.01
1.2
1.1
—
11.70
—
0
25
29
297
0.98
0.01
1.5
1.7
7.15
7.50
mmol/l
0.51
29
285
281
2819
1.00
0.01
6.4
4.3
90.64
93.25
%
1.31
273
2740
332
3329
1.00
0.01
8.6
7.0
—
—
—
0
0
12
114
1.05
0.00
3.2
3.6
174.00
250.00
e6/l
—
5
80
101
1003
1.01
0.00
1.3
1.3
—
—
—
0
0
101
1004
1.01
0.00
7.0
4.9
5.03
5.13
kpa
0.91
96
963
13
126
1.03
0.00
2.2
2.5
70.31
78.95
mmol/l
0.21
13
113
95
952
1.00
0.00
1.6
1.6
—
—
—
0
0
100
1002
1.00
0.00
7.0
4.9
7.40
7.41
ph
0.64
13
74
35
354
0.99
0.00
1.2
1.3
4.42
13.09
u/ml
—
5
55
12
122
0.98
0.00
1.1
1.8
—
—
—
0
0
26
259
1.00
0.00
1.5
2.1
8.58
9.48
mg/l
0.35
26
241
15
148
1.01
0.00
1.6
1.5
—
17.00
—
0
6
12
124
0.97
0.00
1.0
1.1
—
—
—
0
0
133
1328
1.00
0.00
1.5
1.4
—
—
—
0
0
13
135
0.96
0.00
1.0
1.3
0.41
0.48
nmol/l
0.65
13
128
10
101
0.99
0.00
1.2
1.0
—
—
—
0
0
14
135
1.04
0.00
1.3
1.3
—
250.00
—
0
6
25
251
1.00
0.00
1.1
1.1
87.56
195.87
iu/ml
—
9
84
11
105
1.05
0.00
1.4
1.2
—
—
—
0
0
17
168
1.01
0.00
7.9
2.7
—
—
—
0
0
49
488
1.00
0.00
4.1
2.9
5.38
6.29
umol/l
0.35
40
384
21
208
1.01
0.00
1.0
1.2
0.32
15.27
u/ml
—
7
89
5
56
0.89
-0.00
1.0
2.2
1.16
1.76
nmol/l
—
5
51
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.3
—
2025.56
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
60
1.00
-0.00
2.7
2.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
281.18
—
0
6
6
68
0.88
-0.00
1.7
1.3
1.45
1.53
g/l
—
6
68
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
3.00
—
0
6
0
5
0.00
-0.00
0.0
2.8
—
—
—
0
0
8
80
1.00
-0.00
6.6
3.3
—
—
—
0
0
7
76
0.92
-0.00
1.6
1.6
0.84
0.98
g/l
—
7
76
0
7
0.00
-0.00
0.0
9.9
—
—
—
0
0
5
51
0.98
-0.00
1.0
1.4
102.60
86.08
nmol/24h
—
5
51
8
84
0.95
-0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
398.33
—
0
6
8
80
1.00
-0.00
1.4
1.3
1.43
1.44
u/ml
—
8
80
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
54
0.93
-0.00
1.8
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
35.24
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint K11_HYPO_ONLY and mortality.

Females

Parameter HR [95% CI] p-value
K11_HYPO_ONLY 1.193 [0.89, 1.61] 0.245
Birth year 0.992 [0.98, 1.0] 0.07

During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 17984 females with K11_HYPO_ONLY died.

Males

Parameter HR [95% CI] p-value
K11_HYPO_ONLY 0.962 [0.71, 1.31] 0.805
Birth year 0.989 [0.98, 1.0] 0.029

During the follow-up period (1.1.1998 — 31.12.2019), 57 out of 12761 males with K11_HYPO_ONLY died.

Mortality risk

Mortality risk for people of age

years, who have K11_HYPO_ONLY.

N-year risk Females Males
1 0.111% 0.2%
5 0.683% 1.062%
10 1.67% 2.862%
15 2.925% 5.365%
20 5.103% 9.419%

Relationships between endpoints

Index endpoint: K11_HYPO_ONLY – Tooth agenesis EXCLUDE clefts and syndromes

GWS hits: 13

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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