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Other and unspecified epidermal thickening

EFO MESH Endpoint Browser PheWeb

L12_EPIDERMTHICKNAS

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L85.80, L85.81, L85.89, L85.9
  • Hospital discharge: ICD-9 — 7018G
  • Hospital discharge: ICD-8 — 70119
  • Cause of death: ICD-10 — L85.80, L85.81, L85.89, L85.9
  • Cause of death: ICD-9 — 7018G
  • Cause of death: ICD-8 — 70119

2 out of 7 registries used, show all original rules.

991

4. Check minimum number of events

None

991

5. Include endpoints

None

991

6. Filter based on genotype QC (FinnGen only)

991

Control definitions (FinnGen only)

Control exclude
L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7347 3872 3440
Only index persons 6683 3612 3071
Unadjusted period prevalence (%)
Whole population 0.10 0.11 0.10
Only index persons 0.13 0.13 0.12
Median age at first event (years)
Whole population 51.27 51.51 50.95
Only index persons 51.20 51.44 50.92

-FinnGen-

Key figures

All Female Male
Number of individuals 991 553 438
Unadjusted period prevalence (%) 0.19 0.19 0.19
Median age at first event (years) 54.34 50.74 58.89

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
904
Matched controls
9040
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L85.9
ICD-10 Finland
Epidermal thickening, unspecified
2588.8
323.0
328
*
L85.89
ICD-10 Finland
Other specified epidermal thickening
+∞
267.3
243
*
L85.81
ICD-10 Finland
Keratosis pilaris
2724.3
213.2
198
*
L85.80
ICD-10 Finland
Hudhorn
284.8
144.8
144
6
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
10.5
117.2
249
316
E0000UV
ATC
NA
4.6
100.9
562
2372
D07XC01
ATC
betamethasone, combinations; topical
6.4
89.0
269
563
L30.9
ICD-10 Finland
Dermatitis, unspecified
5.1
84.2
321
878
D02AE01
ATC
carbamide; topical
8.5
82.7
195
282
D05BB02
ATC
acitretin; oral
15.9
66.4
111
79
L84
ICD-10 Finland
Corns and callosities
18.3
65.3
103
63
D07AC01
ATC
betamethasone; topical
3.1
53.0
404
1850
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
14.4
51.5
89
68
D07AD01
ATC
clobetasol; topical
4.0
48.5
226
698
TQW80
NOMESCO Finland
Local dermatologic skincare
12.9
48.0
87
74
R4180
NOMESCO Finland
Podiatric therapy
32.1
47.8
63
21
L85.3
ICD-10 Finland
Xerosis cutis
32.6
46.4
61
20
E000001
ATC
NA
3.2
43.4
280
1107
L57.0
ICD-10 Finland
Actinic keratosis
4.8
42.7
156
377
E000003
ATC
NA
7.1
41.5
106
165
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
51.7
41.1
49
10
D07AC13
ATC
mometasone; topical
2.6
35.0
329
1614
E000006
ATC
NA
4.8
33.9
120
278
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
21.5
33.4
49
24
B07.9
ICD-10 Finland
Verruca simplex
7.3
31.6
78
115
70119
ICD-8 Finland
Other hypertrophic and atrophic conditions of the skin, Keratosis, hyperkeratosis alia sive NUD
+∞
31.4
30
*
L40.0
ICD-10 Finland
Psoriasis vulgaris
5.9
30.8
90
167
SPAT1148
SPAT
Treatment of chronic ulcer or burn
3.2
27.0
160
574
D07AB08
ATC
desonide; topical
3.4
26.1
142
476
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
3.4
25.7
136
448
D07BC01
ATC
betamethasone and antiseptics; topical
3.1
25.5
156
571
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
7.5
24.7
59
83
A46
ICD-10 Finland
Erysipelas
3.0
24.6
162
619
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
6.7
24.6
64
102
S18
ICPC
Laceration/cut
2.1
23.7
404
2520
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.4
23.6
239
1172
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
22.0
410
2629
C03CA01
ATC
furosemide; systemic
2.2
21.2
261
1400
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
21.2
278
1531
L04AA06
ATC
mycophenolic acid; systemic
11.6
21.1
39
35
S97
ICPC
Chronic ulcer skin
5.1
20.9
68
143
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
3.4
20.9
106
337
E000002
ATC
NA
2.9
20.8
138
527
L30.4
ICD-10 Finland
Erythema intertrigo
11.3
20.8
39
36
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.7
20.6
152
623
D05AX02
ATC
calcipotriol; topical
4.7
20.0
69
155
H02AB06
ATC
prednisolone; systemic
1.9
19.9
432
2896
RJ411
NOMESCO Finland
NA
75.2
19.8
22
*
B35.3
ICD-10 Finland
Tinea pedis
4.6
19.7
70
162
A12AA04
ATC
calcium carbonate; oral
14.2
19.6
33
24
J01FF01
ATC
clindamycin; systemic
2.1
19.4
262
1453
127
Kela drug reimbursment
Transplant complication
10.7
19.3
37
36
D07AA02
ATC
hydrocortisone; topical
2.6
19.2
155
668
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.6
19.0
153
655
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.6
19.0
153
657
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
35.1
19.0
24
7
XQ848
NOMESCO Finland
Dermatological photography
7.5
18.7
44
61
D05AX52
ATC
calcipotriol, combinations; topical
3.8
18.6
82
232
L04AX01
ATC
azathioprine; systemic
4.5
18.5
67
158
D07AB02
ATC
hydrocortisone butyrate; topical
2.1
18.5
277
1601
L04AA01
ATC
[U] ciclosporin; systemic
9.8
18.0
36
38
SPAT1153
SPAT
Removal of sutures
2.0
17.7
301
1821
L04AD01
ATC
ciclosporin; systemic
8.1
17.4
39
50
J01DB01
ATC
cefalexin; oral
2.0
17.3
731
6087
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.8
17.3
120
472
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.6
17.2
134
560
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
8.2
17.2
38
48
E000007
ATC
NA
3.6
16.8
77
225
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
7.5
16.6
39
54
A11CC03
ATC
alfacalcidol; systemic
7.2
16.5
40
58
UJF32
NOMESCO Finland
Coloscopy
2.1
16.4
231
1291
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
16.1
203
1081
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
3.2
16.1
87
290
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.3
15.5
161
783
L82
ICD-10 Finland
Seborrhoeic keratosis
2.4
15.5
136
610
D09AB01
ATC
zinc bandage without supplements; topical
7.1
15.3
37
54
B35.1
ICD-10 Finland
Tinea unguium
3.4
15.2
74
228
-
ICD-10 Finland
NA
5.7
15.0
43
79
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.1
14.8
200
1090
L85.1
ICD-10 Finland
Acquired keratosis [keratoderma] palmaris et plantaris
81.4
14.6
16
*
L91.0
ICD-10 Finland
Hypertrophic scar
36.7
14.5
18
5
D01AE15
ATC
terbinafine; topical
3.1
14.4
83
289
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.9
14.4
261
1594
A10AE04
ATC
insulin glargine; parenteral
2.8
14.4
99
386
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
4.1
14.3
56
143
R06.0
ICD-10 Finland
Dyspnoea
2.0
14.3
224
1297
J01DA01
ATC
[U] cefalexin; systemic
1.7
14.3
550
4266
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
3.1
14.0
80
277
E000004
ATC
NA
5.5
13.9
41
78
L20.0
ICD-10 Finland
Besnier prurigo
3.1
13.8
79
273
SPAT1312
SPAT
General health counselling
1.8
13.7
301
1956
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
3.2
13.7
73
241
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
13.7
279
1770
D02AX
ATC
Other emollients and protectives
4.3
13.4
49
118
R23.8
ICD-10 Finland
Other and unspecified skin changes
2.2
13.3
143
704
D01BA02
ATC
terbinafine; oral; topical
1.9
13.2
230
1376
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
19.4
12.9
19
10
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.8
12.9
83
310
L30.8
ICD-10 Finland
Other specified dermatitis
5.1
12.9
40
81
Z94.0
ICD-10 Finland
Kidney transplant status
10.7
12.8
24
23
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.2
12.7
143
719
TK800
NOMESCO Finland
Hemodialysis
6.3
12.7
33
54
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.9
12.7
207
1211
SPAT1249
SPAT
Treatment-related counselling outside office
1.7
12.6
357
2493
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
4.1
12.6
49
125
ZXC50
NOMESCO Finland
Cryotherapy
4.7
12.6
42
92
RJ420
NOMESCO Finland
NA
32.5
12.6
16
5
TNX92
NOMESCO Finland
Supporting bandage or orthosis of lower limb
7.5
12.5
29
40
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
5.7
12.5
35
63
WXQ12
NOMESCO Finland
Psoralen - Ultraviolet A therapy with local sensitivisation
20.4
12.5
18
9
103
Kela drug reimbursment
Diabetes, insulin-treated
1.9
12.4
224
1353
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
5.8
12.3
34
60
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.4
12.3
59
180
TQW99
NOMESCO Finland
Other minor procedure on skin
3.6
12.3
56
164
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
12.2
311
2097
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.8
12.2
251
1584
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
16.1
12.2
19
12
L30.3
ICD-10 Finland
Infective dermatitis
3.9
12.1
49
130
L17
ICPC
Foot/toe symptom/complaint
1.9
12.1
224
1364
S20
ICPC
Corn/callosity
6.1
12.0
32
54
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
5.0
12.0
38
79
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.7
12.0
82
319
C07AB07
ATC
bisoprolol; oral
1.7
12.0
377
2703
N02AX02
ATC
tramadol; systemic, rectal
1.7
12.0
351
2466
N02BE01
ATC
paracetamol; systemic, rectal
1.8
11.9
745
6488
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
3.1
11.8
66
224
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
8.3
11.6
25
31
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.3
11.6
111
517
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.7
11.6
366
2620
L50.3
ICD-10 Finland
Dermatographic urticaria
6.2
11.4
30
50
SPAT1301
SPAT
No procedures
1.7
11.4
289
1938
D07CC01
ATC
betamethasone and antibiotics; topical
2.1
11.3
129
650
R50.9
ICD-10 Finland
Fever, unspecified
2.1
11.3
145
767
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
4.9
11.3
36
76
A02BC02
ATC
pantoprazole; systemic
1.6
11.1
533
4249
H03AA01
ATC
levothyroxine sodium; systemic
1.8
11.1
199
1198
A41.9
ICD-10 Finland
Sepsis, unspecified
4.4
11.0
39
92
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
6.4
11.0
28
45
SPAT1263
SPAT
Sampling
1.6
10.9
374
2726
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.3
10.8
106
499
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
4.5
10.8
37
84
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.5
10.8
50
149
J02AC01
ATC
fluconazole; systemic
1.7
10.8
328
2308
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.9
10.8
184
1085
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
10.7
10.8
20
19
XQ802
NOMESCO Finland
Epicutan test
3.5
10.7
50
150
QAA50
NOMESCO Finland
Cryotherapy of skin of head or neck
13.1
10.7
18
14
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.1
10.7
125
639
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
10.7
197
1192
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
7.1
10.6
25
36
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.0
10.6
146
797
B03XA01
ATC
erythropoietin; parenteral
10.2
10.5
20
20
R06AE07
ATC
cetirizine; oral
1.6
10.4
377
2775
N03AX12
ATC
gabapentin; oral
2.0
10.4
133
702
L89
ICD-10 Finland
Decubitus ulcer and pressure area
16.2
10.4
16
10
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.4
10.4
90
399
137
Kela drug reimbursment
Uraemia requiring dialysis
10.8
10.3
19
18
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
10.8
10.3
19
18
ZZA00
NOMESCO Finland
Split skin graft
4.4
10.3
36
84
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
3.6
10.3
46
134
PD4CC
NOMESCO Finland
Very extensive arterigography of lower extremity with X-ray
13.3
10.2
17
13
J01CE08
ATC
benzathine benzylpenicillin; parenteral
8.0
10.1
22
28
G47.3
ICD-10 Finland
Sleep apnoea
1.8
10.1
180
1074
J01FA06
ATC
roxithromycin; oral
1.6
10.0
330
2369
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.7
9.7
224
1448
D05AX03
ATC
calcitriol; topical
6.2
9.7
25
41
D01AC02
ATC
miconazole; topical
2.4
9.7
81
353
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
13.5
9.7
16
12
A10AA01
ATC
NA
4.4
9.7
34
80
ZX120
NOMESCO Finland
Intravenous
2.3
9.6
89
409
S76
ICPC
Skin infection other
2.9
9.6
57
204
J45.9
ICD-10 Finland
Asthma, unspecified
1.9
9.6
149
849
I10
ICD-10 Finland
Essential (primary) hypertension
1.6
9.6
453
3540
A10AE05
ATC
insulin detemir; parenteral
2.9
9.6
59
214
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
4.3
9.6
34
81
SPAT1101
SPAT
Orthostatic test
3.4
9.5
45
137
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.9
9.5
148
841
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.0
9.5
54
187
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
5.0
9.5
29
59
XCD10
NOMESCO Finland
Electrophysiological examination of eye
4.4
9.5
33
77
L20.8
ICD-10 Finland
Other atopic dermatitis
7.6
9.4
21
28
Q82.82
ICD-10 Finland
Inherited keratosis palmaris et plantaris
101.0
9.4
10
*
M14.6*E10.6
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic neuropathic
101.0
9.4
10
*
NH3CG
NOMESCO Finland
Extensive MRI of foot
17.7
9.4
14
8
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.1
9.4
107
538
SPAT1325
SPAT
Vaccination
1.6
9.3
296
2094
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
5.3
9.3
27
52
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.3
9.3
83
374
QDA10
NOMESCO Finland
Incision of skin of lower limb
13.8
9.2
15
11
AA1AD
NOMESCO Finland
CT of head and brain
1.8
9.1
189
1182
A10AA02
ATC
NA
3.7
9.1
38
105
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.1
9.1
99
490
8070/3-C44.9
ICD-O-3
Squamous cell carcinoma, NOS, of skin, NOS
7.1
9.1
21
30
NH3BG
NOMESCO Finland
MRI of foot
10.2
9.0
17
17
XQ800
NOMESCO Finland
Prick test
2.4
9.0
76
331
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
2.0
9.0
126
691
A06AC01
ATC
ispaghula (psylla seeds); oral
1.7
8.9
196
1247
T90
ICPC
Diabetes non-insulin dependent
1.8
8.9
181
1127
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.7
8.7
37
104
R03AC02
ATC
salbutamol; inhalant
1.5
8.7
432
3387
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
50.5
8.7
10
*
R03BB04
ATC
tiotropium bromide; inhalant
2.2
8.6
86
407
205
Kela drug reimbursment
Chronic hypertension
1.7
8.6
212
1396
N05BA04
ATC
oxazepam; oral
1.7
8.6
199
1287
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.8
8.5
157
947
L30.0
ICD-10 Finland
Nummular dermatitis
3.3
8.5
41
128
M04AA01
ATC
allopurinol; systemic
2.0
8.5
107
562
A10BA02
ATC
metformin; oral
1.7
8.5
217
1444
SPAT1262
SPAT
Handing over of treatment supplies
1.8
8.5
155
932
A06AD11
ATC
lactulose; oral
1.9
8.5
120
658
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
3.6
8.4
37
107
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
8.4
323
2381
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.8
8.4
161
980
A07AA09
ATC
vancomycin; oral
6.8
8.4
20
30
Z49.1
ICD-10 Finland
Extracorporeal dialysis
6.8
8.4
20
30
D01AE16
ATC
amorolfine; topical
2.1
8.4
100
513
SPAT1229
SPAT
Assessment of need for aid
2.4
8.4
69
297
I50.9
ICD-10 Finland
Heart failure, unspecified
2.0
8.3
102
530
L73.8
ICD-10 Finland
Other specified follicular disorders
8.6
8.3
17
20
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
3.4
8.3
38
114
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
9.6
8.3
16
17
J01CF05
ATC
flucloxacillin; systemic
3.3
8.3
40
125
R60.0
ICD-10 Finland
Localized oedema
2.1
8.3
91
452
N05AH04
ATC
quetiapine; oral
1.8
8.2
143
842
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
14.6
8.2
13
9
V03AE01
ATC
polystyrene sulfonate; oral
8.2
8.1
17
21
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
8.1
169
1059
K92.1
ICD-10 Finland
Melaena
2.8
8.0
51
191
H02AB09
ATC
hydrocortisone; systemic
3.8
8.0
32
86
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.5
8.0
317
2346
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
2.9
8.0
47
169
J02AC02
ATC
itraconazole; systemic
1.8
7.9
144
863
M54.5
ICD-10 Finland
Low back pain
1.6
7.9
260
1840
H02AB04
ATC
methylprednisolone; systemic
1.9
7.9
127
731
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
7.8
7.9
17
22
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
13.2
7.9
13
10
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.3
7.9
69
308
J01AA02
ATC
doxycycline; systemic
1.5
7.9
635
5485
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
2.6
7.8
57
231
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
3.6
7.8
33
93
A02BC05
ATC
esomeprazole; systemic
1.5
7.8
315
2338
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.9
7.8
119
672
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
4.9
7.8
24
50
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
2.8
7.8
47
172
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
7.8
355
2712
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
6.0
7.7
20
34
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
7.7
142
855
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
3.0
7.7
42
144
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.6
7.7
275
1984
C08CA02
ATC
felodipine; oral
2.2
7.6
77
367
N08.2
ICD-10 Finland
Glomerular disorders in blood diseases and disorders involving the immune mechanism
18.5
7.6
11
6
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
6.8
7.6
18
27
SPAT1254
SPAT
Administration of medicine
1.8
7.6
126
735
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.9
7.5
111
618
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.1
7.5
84
422
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
7.5
339
2576
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.6
7.5
52
207
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
3.2
7.4
37
119
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.5
7.4
265
1909
N03AX16
ATC
pregabalin; oral
1.7
7.4
184
1209
L40.9
ICD-10 Finland
Psoriasis, unspecified
5.3
7.4
21
40
N18.8
ICD-10 Finland
Other chronic renal failure
3.9
7.4
29
77
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
2.2
7.4
78
380
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.1
7.4
83
418
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
4.4
7.4
25
58
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
4.4
7.4
25
58
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.2
7.4
73
346
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.6
7.4
214
1463
J04AB02
ATC
rifampicin; systemic
6.9
7.3
17
25
E66.01
ICD-10 Finland
Obesity due to excess calories
2.2
7.3
70
327
P01AB01
ATC
metronidazole; oral, rectal
1.5
7.2
307
2297
C07AB02
ATC
metoprolol; systemic
1.7
7.2
161
1027
V03AE02
ATC
sevelamer; oral
30.3
7.2
9
*
RJ421
NOMESCO Finland
NA
30.3
7.2
9
*
8070/3-C44.2
ICD-O-3
Squamous cell carcinoma, NOS, of external ear
30.3
7.2
9
*
J45.1
ICD-10 Finland
Nonallergic asthma
2.2
7.1
69
322
SPAT1234
SPAT
Support of social functional capacity
2.7
7.1
49
191
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
20.2
7.1
10
5
R13
ICD-10 Finland
Dysphagia
2.5
7.1
54
226
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
3.7
7.1
29
80
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
4.6
7.1
23
51
C02AC05
ATC
moxonidine; oral
2.9
7.1
41
145
E66.00
ICD-10 Finland
Metabolic syndrome
2.8
7.1
45
168
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
12.1
7.1
12
10
L60.0
ICD-10 Finland
Ingrowing nail
2.7
7.1
45
169
E66.8
ICD-10 Finland
Other obesity
2.5
7.0
52
213
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.1
7.0
74
363
R03BA02
ATC
budesonide; inhalant
1.7
7.0
144
895
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.1
6.9
75
373
G56.0
ICD-10 Finland
Carpal tunnel syndrome
1.9
6.9
106
600
X59
ICD-10 Finland
Exposure to unspecified factor
1.7
6.9
152
965
L40.3
ICD-10 Finland
Pustulosis palmaris et plantaris
4.9
6.9
21
44
SPAT1147
SPAT
Destruction of skin lesion with external methods
4.2
6.8
24
58
SPAT1210
SPAT
Application of cast or individual aid
2.8
6.8
41
151
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.2
6.8
69
331
SPAT1310
SPAT
Counselling related to known health issue
1.5
6.8
264
1936
QDA99
NOMESCO Finland
Other local destruction of skin of lower limb
16.8
6.8
10
6
QBA99
NOMESCO Finland
Other local destruction of skin of trunk
16.8
6.8
10
6
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
6.7
174
1153
K83.0
ICD-10 Finland
Cholangitis
5.0
6.7
20
41
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.4
6.7
54
234
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.8
6.7
106
606
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.0
6.7
82
429
R03DC03
ATC
montelukast; oral
1.8
6.6
126
762
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.9
6.6
91
494
SPAT1216
SPAT
Assessment of functional ability
1.8
6.6
119
710
B05DA
ATC
Isotonic solutions
8.8
6.6
13
15
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
10.1
6.5
12
12
S29
ICPC
Skin symptom/complaint other
1.7
6.5
138
864
CKC12
NOMESCO Finland
Photocoagulation of retina
2.8
6.5
40
149
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
6.9
6.5
15
22
SPAT1255
SPAT
Intravenous administration of medicine
2.3
6.5
56
251
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.4
6.5
52
223
B01AC04
ATC
clopidogrel; oral
1.8
6.5
120
722
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
6.5
205
1430
C08CA01
ATC
amlodipine; oral
1.5
6.4
264
1951
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.6
6.4
45
179
D06BB10
ATC
imiquimod; topical
2.6
6.4
45
179
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
70.3
6.4
7
*
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
7.5
6.4
14
19
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
7.5
6.4
14
19
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
4.1
6.4
23
57
M25.5
ICD-10 Finland
Pain in joint
1.5
6.4
219
1552
C44.72
ICD-10 Finland
Spinocellular carcinoma of the skin of the lower extremity including the hip
14.4
6.4
10
7
R03AC03
ATC
terbutaline; inhalant
1.8
6.4
117
701
E11
ICD-10 Finland
Type 2 diabetes mellitus
1.8
6.4
117
701
EBA00
NOMESCO Finland
Extraction of tooth
1.5
6.3
263
1949
A05AA02
ATC
ursodeoxycholic acid; oral
4.2
6.3
22
53
L21.9
ICD-10 Finland
Seborrhoeic dermatitis, unspecified
4.2
6.3
22
53
SPAT1211
SPAT
Application of soft bandage
2.0
6.3
83
444
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
3.6
6.3
26
73
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
9.3
6.3
12
13
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
2.3
6.3
56
253
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.1
6.3
68
336
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
18.2
6.3
9
5
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.9
6.3
85
462
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.5
6.3
257
1898
L85.8
ICD-10 Finland
Other specified epidermal thickening
+∞
6.3
6
*
L21.8
ICD-10 Finland
Other seborrhoeic dermatitis
4.8
6.2
19
40
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.3
6.2
54
243
CJB10
NOMESCO Finland
Laser discission of secondary cataract
2.2
6.2
63
302
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
2.7
6.2
41
159
L92.0
ICD-10 Finland
Granuloma annulare
26.9
6.2
8
*
M14.6*A52.1
ICD-10 Finland
Charcot's or tabetic arthropathy
26.9
6.2
8
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.6
6.2
42
166
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
2.7
6.2
38
142
N02AC04
ATC
dextropropoxyphene; oral
3.0
6.2
33
113
J01MA02
ATC
ciprofloxacin; systemic
1.5
6.2
295
2250
T82
ICPC
Obesity
2.9
6.2
35
122
C09AA02
ATC
enalapril; systemic
1.6
6.1
148
960
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
3.3
6.1
29
91
L03.1
ICD-10 Finland
Cellulitis of other parts of limb
3.5
6.1
26
75
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.2
6.1
56
259
C10AA01
ATC
simvastatin; oral
1.4
6.1
318
2462
A02BC01
ATC
omeprazole; systemic
1.5
6.1
212
1509
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.3
6.1
52
229
196
Kela drug reimbursment
Paricalcitol and cinacalcet
12.6
6.1
10
8
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.0
6.1
79
421
M05BA04
ATC
alendronic acid; oral
2.1
6.1
64
312
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
2.7
6.0
39
148
H3603, E103
ICD-10 Finland
NA
6.7
6.0
14
21
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
10.1
6.0
11
11
D06AX01
ATC
fusidic acid; topical (antibiotics for topical use)
1.9
6.0
83
453
TGC00
NOMESCO Finland
Bronchial lavation
3.6
6.0
25
71
D06BX02
ATC
ingenol mebutate; topical
5.2
6.0
17
33
A08
ICPC
Swelling
2.7
6.0
37
139
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.5
6.0
204
1443
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
5.6
6.0
16
29

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
231
891
3.08
44.35
2.4
1.4
—
—
—
0
0
108
283
4.16
37.30
1.2
1.2
—
—
—
0
0
594
3896
2.31
35.37
9.2
5.6
0.6
0.6
e9/l
0.40
547
3344
608
4028
2.32
35.33
9.2
5.6
1.9
1.9
e9/l
0.08
568
3544
337
1742
2.42
35.17
6.9
4.3
—
—
—
0
0
595
3917
2.30
34.95
9.2
5.6
0.0
0.0
e9/l
0.42
550
3374
168
618
3.07
34.43
5.4
3.1
—
—
—
0
0
604
4059
2.25
32.94
9.6
5.9
0.2
0.2
e9/l
0.09
562
3549
657
4573
2.30
32.84
12.5
8.9
4.3
4.1
e9/l
2.07
614
3974
210
914
2.65
31.19
1.8
1.4
—
—
—
0
0
364
2084
2.18
28.65
5.8
3.7
0.0
0.0
estimate
0.50
90
705
173
721
2.70
27.79
5.3
4.2
2.2
2.0
mmol/l
0.30
135
571
310
1718
2.17
26.06
5.9
3.7
1.0
1.0
kg/l
0.05
35
240
316
1771
2.15
25.76
5.7
3.5
—
—
—
0
0
170
731
2.60
25.52
5.4
4.2
6.0
5.8
kpa
1.36
165
709
488
3245
1.99
24.61
7.8
4.7
35.4
35.7
g/l
0.61
467
3018
552
3868
1.96
23.51
5.3
3.5
0.0
0.0
estimate
0.00
90
722
551
3870
1.95
23.18
6.5
4.8
0.0
0.0
estimate
0.00
95
728
554
3913
1.94
22.76
5.3
3.5
0.0
0.0
estimate
0.00
88
705
102
355
3.09
22.67
4.1
3.0
0.7
0.7
%
0.96
96
344
90
293
3.28
22.36
7.5
4.5
—
—
—
0
0
146
625
2.57
21.95
4.8
3.6
4.8
4.6
kpa
0.65
141
604
209
1067
2.22
21.04
2.6
1.9
—
—
—
0
0
465
3208
1.85
19.47
3.1
2.3
75.0
76.1
nmol/l
0.34
420
2865
607
4591
1.83
18.39
6.8
4.8
7.1
6.6
mmol/l
3.57
573
4271
133
592
2.44
18.27
3.2
2.6
10.2
10.5
g/l
0.45
121
542
348
2243
1.85
17.72
2.7
2.1
190.2
271.9
u/l
0.93
330
2119
78
269
3.06
17.56
1.5
1.2
1.4
1.7
u/ml
—
6
17
726
5878
1.88
16.84
6.3
3.9
13.7
11.9
mm/h
2.58
694
5404
139
654
2.31
16.79
7.3
9.2
—
—
—
0
0
328
2108
1.83
16.65
4.0
3.1
2052.9
1286.5
ng/l
1.21
294
1788
312
1982
1.84
16.41
3.1
2.2
3.4
3.0
mg/l
2.09
284
1688
131
620
2.28
15.57
3.0
2.5
5.1
7.6
ug/l
1.54
120
548
735
6040
1.84
15.43
11.2
7.1
82.3
78.4
u/l
1.11
705
5652
322
2097
1.79
15.42
5.8
4.1
—
—
—
0
0
211
1202
1.96
15.40
4.1
2.3
11.6
13.5
umol/l
3.94
202
1105
186
1023
2.01
14.98
1.5
1.3
569.2
491.9
titre
0.21
39
209
339
2269
1.75
14.62
8.0
3.7
7.4
7.4
ph
0.00
62
409
410
2897
1.71
14.52
5.0
3.5
51.4
59.4
ng/l
0.19
298
1943
740
6157
1.80
14.12
4.9
3.9
14.8
14.7
pmol/l
0.27
697
5586
508
3819
1.68
14.11
11.2
6.6
1.2
1.2
mmol/l
4.16
443
3221
353
2412
1.72
14.02
3.9
2.4
56.4
56.8
u/l
0.03
332
2231
300
1968
1.75
13.73
4.3
2.6
5006.2
7982.7
umol/l
0.57
272
1715
472
3498
1.67
13.72
10.1
6.0
1.2
1.2
mmol/l
4.97
443
3149
142
736
2.08
13.37
2.0
2.1
352.2
374.1
nmol/l
0.55
128
677
107
495
2.30
13.37
1.4
1.2
249.6
248.7
u/ml
0.00
99
450
271
1740
1.77
13.30
2.2
1.7
1.1
1.1
mg/l
0.17
205
1314
205
1212
1.87
13.19
6.3
3.7
0.8
0.8
mmol/l
0.55
191
1138
528
4053
1.65
13.18
8.7
6.1
10.7
11.3
umol/l
0.89
508
3838
180
1021
1.93
13.14
4.1
2.4
21.4
23.4
%
1.15
160
869
472
3529
1.64
13.03
3.8
2.7
124.9
120.6
ug/l
0.16
450
3246
296
1959
1.73
13.01
8.3
6.7
—
—
—
0
0
190
1101
1.90
12.99
4.1
2.3
2.3
2.4
g/l
0.92
181
1018
104
484
2.28
12.80
5.5
5.6
—
—
—
0
0
420
3068
1.64
12.59
9.8
9.0
1.2
1.2
inr
0.63
122
899
131
674
2.09
12.55
5.5
7.8
1.2
1.4
mmol/l
1.45
126
643
333
2301
1.67
12.35
4.6
3.9
17.8
9.8
mg/mmol
0.75
241
1442
423
3109
1.63
12.28
2.5
2.0
—
—
—
0
0
345
2409
1.66
12.28
3.9
3.1
7.2
7.7
mmol/l
1.45
300
2026
98
458
2.26
11.94
8.8
7.9
23.8
24.6
mmol/l
1.01
93
429
252
1642
1.72
11.51
3.5
2.5
6.4
5.8
e6/l
0.19
229
1449
316
2188
1.65
11.47
4.1
3.2
78.4
296.6
mg/l
1.97
235
1389
639
5246
1.61
11.34
5.8
4.3
69.8
3076.4
e6/l
—
10
81
114
580
2.09
11.22
6.2
3.9
124.7
79.3
ng/l
3.01
104
511
888
8009
2.05
10.88
23.9
13.2
22.1
24.3
mg/l
1.39
763
6269
130
703
1.98
10.81
3.4
2.3
0.2
0.2
g/l
0.07
121
655
361
2618
1.60
10.69
3.6
3.3
2.3
2.4
mmol/l
0.82
325
2292
833
7373
1.81
10.62
5.8
4.6
1.9
1.9
mu/l
0.07
784
6743
217
1398
1.71
10.20
1.8
1.7
1320.5
1180.1
nmol/l
1.26
185
1051
91
441
2.17
10.14
1.5
1.2
—
—
—
0
0
474
3691
1.54
10.11
9.7
5.7
2.7
2.9
%
1.25
451
3436
461
3568
1.55
10.11
9.7
5.8
0.7
0.7
%
0.04
442
3328
413
3123
1.55
10.04
2.1
1.9
91.9
94.7
pmol/l
0.64
247
1624
476
3715
1.54
10.01
10.0
6.0
8.4
8.5
%
0.51
454
3482
242
1618
1.66
9.85
1.7
1.7
449.1
30633713.5
pmol/l
1.70
204
1358
94
467
2.12
9.83
1.8
1.7
1.0
1.4
g/l
2.69
86
430
150
879
1.83
9.74
4.1
2.7
1.8
1.8
%
0.13
138
789
485
3830
1.52
9.48
9.8
5.8
27.3
28.2
%
0.81
462
3568
478
3770
1.52
9.35
9.5
5.6
58.1
57.0
%
1.25
459
3531
652
5500
1.54
9.24
6.0
4.1
—
—
—
0
0
117
645
1.92
9.17
2.5
2.6
72.6
71.0
e9/l
0.24
103
504
82
397
2.16
9.16
4.6
4.9
24.4
24.2
mmol/l
0.24
65
361
301
2166
1.56
8.89
3.9
3.1
0.3
0.5
e6/l
1.51
247
1645
47
180
2.69
8.80
2.4
2.5
219.2
101.3
ug/min
0.83
28
114
804
7152
1.66
8.76
7.6
5.5
41.6
39.5
mmol/mol
5.85
754
6617
205
1350
1.65
8.74
1.4
1.3
34.0
32.4
iu/ml
0.06
70
427
449
3533
1.50
8.66
12.8
9.0
0.0
0.0
e9/l
0.02
399
2855
368
2792
1.51
8.42
4.7
3.7
46.2
114.9
e6/l
1.52
280
1980
75
364
2.15
8.34
2.6
2.3
—
—
—
0
0
350
2637
1.51
8.24
8.2
5.6
—
—
—
0
0
139
837
1.77
8.20
6.8
8.5
1.5
1.3
mmol/l
0.28
112
653
317
2348
1.51
8.06
3.6
2.9
—
—
—
0
0
208
1407
1.61
7.90
3.0
3.0
2.4
2.4
mmol/l
0.13
188
1227
225
1560
1.57
7.68
2.1
1.9
—
—
—
0
0
287
2119
1.50
7.28
3.9
3.0
—
—
—
0
0
888
8209
1.79
7.23
26.0
15.2
4.0
4.0
mmol/l
2.82
874
7953
108
628
1.81
7.15
4.4
4.1
0.8
0.9
%
0.22
43
180
886
8191
1.77
7.14
25.8
15.1
139.4
139.7
mmol/l
1.92
873
7955
149
955
1.66
6.97
2.2
1.5
—
—
—
0
0
256
1861
1.51
6.96
1.4
1.3
1.5
1.5
u/ml
0.03
78
485
633
5454
1.44
6.96
5.2
3.6
—
—
—
0
0
95
538
1.85
6.85
5.9
3.8
5.2
5.1
kpa
0.41
85
504
175
1176
1.59
6.76
3.4
2.1
29.5
29.7
s
0.20
170
1139
37
146
2.59
6.59
6.0
4.2
—
—
—
0
0
93
534
1.82
6.42
6.0
3.8
7.4
7.4
ph
0.64
11
53
251
1845
1.48
6.40
1.6
1.5
19.0
20.8
nmol/l
0.98
221
1556
32
119
2.75
6.39
2.3
1.4
—
—
—
0
0
27
92
2.99
6.30
2.3
1.4
—
—
—
0
0
27
92
2.99
6.30
2.3
1.4
—
—
—
0
0
27
92
2.99
6.30
2.3
1.4
—
—
—
0
0
27
92
2.99
6.30
2.3
1.4
—
—
—
0
0
35
138
2.59
6.25
3.4
2.7
—
—
—
0
0
187
1299
1.54
6.22
1.4
1.3
6.4
12.1
u/ml
0.86
71
497
907
8504
1.79
6.11
16.1
9.7
26.5
26.1
u/l
0.35
887
8187
38
158
2.46
6.10
6.5
4.2
2.6
2.5
mmol/l
0.08
33
110
309
2384
1.43
6.06
4.3
3.2
31.8
88.7
e6/l
1.30
253
1853
12
23
5.27
6.02
1.0
1.0
—
—
—
0
0
145
960
1.60
5.93
28.3
23.3
1.4
1.3
inr
0.61
27
127
99
594
1.74
5.90
4.5
4.2
0.2
0.1
%
0.22
38
164
223
1633
1.47
5.73
1.8
1.4
2.2
2.4
g/l
0.50
152
998
64
338
1.96
5.72
1.3
2.2
1.5
1.5
g/l
0.10
56
302
21
66
3.23
5.62
2.5
2.5
1.4
1.2
e9/l
0.47
12
35
813
7462
1.50
5.57
5.1
3.8
1.4
1.3
mmol/l
3.86
756
6841
831
7662
1.52
5.57
5.6
4.3
6.1
5.9
mmol/l
4.09
773
6983
47
224
2.15
5.54
5.6
3.8
8.4
8.6
kpa
0.19
39
207
899
8447
1.69
5.49
21.9
12.4
—
—
—
0
0
447
3727
1.36
5.36
4.8
4.0
—
—
—
0
0
17
48
3.59
5.34
1.9
2.7
12.3
12.0
%
—
7
28
60
320
1.93
5.23
2.6
2.3
4093.0
4156.7
u/l
0.01
20
130
852
7922
1.54
5.23
5.9
4.7
2.7
2.8
mmol/l
2.14
791
7300
19
59
3.26
5.19
2.3
2.0
846.4
850.0
e6/l
—
7
21
94
577
1.70
5.18
4.2
3.9
0.4
0.5
%
0.34
29
133
13
31
4.24
5.10
1.1
1.1
1686.7
1847.0
miu/ml
0.20
13
31
25
94
2.70
4.94
1.0
1.1
1.6
1.5
g/l
0.31
25
84
82
493
1.72
4.88
1.7
2.5
—
—
—
0
0
41
196
2.14
4.83
4.2
2.9
25.5
24.7
mmol/l
0.47
32
169
11
24
4.62
4.79
4.1
2.3
—
—
—
0
0
95
598
1.65
4.77
2.6
2.9
65.1
67.0
g/l
1.58
90
550
96
607
1.64
4.74
3.6
2.8
194.8
188.6
ng/l
0.06
89
554
142
986
1.51
4.69
3.1
2.3
112.9
120.9
ug/g
0.14
111
776
90
562
1.66
4.66
4.6
4.2
0.0
0.1
%
0.40
30
141
14
38
3.72
4.65
1.1
1.1
110.1
622.7
u/l
1.03
14
32
832
7747
1.46
4.57
5.3
4.2
1.4
1.5
mmol/l
5.49
779
7145
208
1566
1.42
4.52
3.7
2.7
520.5
563.9
mosm/kgh2o
2.13
184
1334
21
76
2.80
4.47
1.4
1.3
2.4
2.8
g/l
0.72
14
55
21
76
2.80
4.47
1.4
1.3
5.9
7.6
g/l
1.22
14
56
21
76
2.80
4.47
1.4
1.3
0.3
0.4
g/l
0.88
15
55
12
30
4.04
4.44
2.5
1.5
—
—
—
0
0
751
6884
1.38
4.39
31.3
17.2
332.0
332.7
g/l
1.29
744
6830
77
470
1.69
4.36
6.5
8.3
24.8
25.0
mmol/l
0.11
77
465
34
158
2.19
4.32
1.8
1.5
270.1
234.9
u/ml
0.30
18
96
32
146
2.23
4.25
1.9
1.5
136.9
98.7
u/ml
—
9
24
32
146
2.23
4.25
3.2
2.4
15.4
16.4
%
0.49
16
71
24
96
2.54
4.24
1.4
1.7
—
—
—
0
0
834
7798
1.44
4.20
5.8
4.2
4.5
4.6
mmol/l
3.78
785
7235
21
79
2.69
4.17
1.4
1.3
—
—
—
0
0
86
547
1.63
4.17
1.8
1.4
—
—
—
0
0
10
23
4.38
4.09
1.1
1.1
—
—
—
0
0
24
98
2.48
4.07
2.9
2.8
—
—
—
0
0
939
9020
1.78
4.07
34.8
19.5
134.4
135.4
g/l
1.18
932
8872
241
1891
1.36
4.05
2.5
2.2
—
—
—
0
0
938
9011
1.77
4.02
34.6
19.4
253.4
250.2
e9/l
0.73
926
8770
51
284
1.84
3.96
1.6
1.3
—
—
—
0
0
938
9015
1.76
3.95
34.4
19.4
90.8
90.7
fl
0.17
931
8872
938
9015
1.76
3.95
34.4
19.3
30.2
30.2
pg
0.51
931
8870
938
9016
1.75
3.94
34.6
19.4
4.5
4.5
e12/l
0.63
922
8755
938
9017
1.75
3.92
34.7
19.4
7.0
6.7
e9/l
2.44
924
8751
9
15
6.04
3.82
1.2
1.3
—
—
—
0
0
38
195
1.99
3.77
1.6
1.2
7.7
2.5
u/ml
—
6
19
171
1288
1.40
3.67
2.0
1.6
—
—
—
0
0
53
308
1.76
3.61
4.8
6.5
0.9
0.9
%
0.56
53
290
735
6795
1.32
3.50
24.4
16.3
13.8
13.6
%
3.50
724
6644
15
52
2.91
3.47
2.6
2.8
42.1
41.3
%
—
6
14
38
202
1.92
3.43
1.2
1.2
50.0
98.7
titre
—
5
15
53
313
1.73
3.42
4.7
6.4
2.0
1.6
%
1.32
53
294
301
2492
1.30
3.42
2.7
2.3
—
—
—
0
0
24
107
2.27
3.40
2.8
3.3
0.8
1.4
%
0.57
18
88
26
121
2.18
3.34
1.6
1.5
0.2
0.3
nmol/l
1.01
21
96
39
212
1.87
3.31
1.4
1.5
213.3
292.4
ug/g
1.44
21
121
9
19
4.77
3.24
2.3
2.5
—
—
—
0
0
9
19
4.77
3.24
5.9
4.9
—
—
—
0
0
32
164
1.98
3.22
2.0
1.5
—
—
—
0
0
38
207
1.87
3.21
1.7
1.5
498.2
475.5
mg/l
0.17
38
195
31
159
1.98
3.12
2.6
2.2
125.1
130.5
g/l
0.39
20
118
123
901
1.42
3.11
4.6
2.9
8.8
8.2
umol/l
0.12
107
773
43
247
1.77
3.08
12.6
9.8
—
—
—
0
0
72
474
1.56
3.08
1.4
1.3
48.6
35.5
au/ml
—
6
24
34
182
1.90
3.04
1.9
1.8
84.2
147.4
e6/l
0.49
29
154
34
182
1.90
3.04
1.8
1.7
11.6
25.7
e6/l
0.37
28
150
132
983
1.40
3.04
1.3
1.3
—
—
—
0
0
28
140
2.03
3.03
1.1
1.1
—
13.2
—
0
10
22
100
2.23
3.01
3.7
2.6
—
—
—
0
0
88
609
1.49
2.99
9.6
3.5
1.2
1.2
mmol/l
0.93
78
511
42
244
1.75
2.91
1.3
1.2
—
—
—
0
0
12
41
2.95
2.86
1.3
1.2
146.2
143.8
nmol/l
0.03
12
41
267
2222
1.28
2.85
4.4
3.7
—
—
—
0
0
10
31
3.25
2.78
2.3
1.6
130.0
53.8
ug/l
—
10
31
21
98
2.17
2.72
1.5
1.4
—
—
—
0
0
25
126
2.01
2.67
1.4
1.7
0.5
0.9
g/l
0.94
18
99
14
55
2.57
2.62
1.1
1.2
—
—
—
0
0
29
513
0.55
2.61
1.6
1.4
—
—
—
0
0
21
100
2.12
2.60
3.4
2.3
—
—
—
0
0
11
38
2.92
2.58
3.1
2.7
552.5
1076.2
u/ml
0.87
11
38
29
158
1.86
2.50
1.9
1.9
—
—
—
0
0
41
248
1.68
2.50
1.5
1.4
11.9
8.3
u/l
0.54
32
198
20
96
2.11
2.44
1.1
1.2
—
—
—
0
0
61
410
1.52
2.42
6.9
3.9
—
—
—
0
0
18
83
2.19
2.42
1.2
1.2
—
—
—
0
0
137
1066
1.33
2.41
1.3
1.2
—
—
—
0
0
14
58
2.43
2.37
1.4
2.6
5.8
2.6
u/field
—
5
27
8
22
3.66
2.36
3.3
1.6
—
—
—
0
0
12
47
2.57
2.27
1.5
1.3
—
—
—
0
0
30
171
1.78
2.27
1.4
2.0
0.8
0.8
nmol/l
0.07
25
147
177
1444
1.27
2.20
4.4
3.7
428.6
559.2
ng/l
0.20
130
1083
113
867
1.34
2.19
1.9
1.7
—
—
—
0
0
17
80
2.14
2.19
1.8
2.2
—
—
—
0
0
234
1973
1.24
2.19
5.8
3.8
89.6
90.3
%
0.16
227
1922
31
182
1.73
2.13
1.8
1.8
7685.9
16294.1
e6/l
1.25
26
138
92
687
1.37
2.13
5.0
3.5
—
—
—
0
0
10
37
2.72
2.10
1.3
1.4
—
—
—
0
0
23
124
1.88
2.08
10.0
3.5
—
—
—
0
0
18
89
2.04
2.06
2.3
2.5
—
—
—
0
0
46
303
1.54
2.04
4.5
3.8
0.2
0.3
g/l
0.30
26
126
15
70
2.16
1.99
2.5
2.8
17.5
24.9
nmol/l
2.17
15
63
116
908
1.31
1.98
1.5
1.7
—
—
—
0
0
82
610
1.38
1.96
1.6
1.4
—
—
—
0
0
12
51
2.37
1.95
1.2
1.0
—
—
—
0
0
22
120
1.85
1.94
1.7
1.6
—
—
—
0
0
252
2170
1.22
1.92
4.1
3.1
—
—
—
0
0
28
168
1.69
1.82
6.6
9.6
103.1
105.5
mmol/l
0.98
28
153
28
168
1.69
1.82
6.6
9.6
12.7
11.2
mmol/l
1.19
28
153
7
23
3.06
1.80
4.7
4.2
57.9
50.1
%
—
7
23
15
74
2.04
1.75
1.5
2.0
—
—
—
0
0
9
36
2.51
1.74
1.8
1.7
1.0
1.2
nmol/l
—
9
28
27
432
0.61
1.74
1.2
1.6
—
—
—
0
0
56
769
0.71
1.70
1.3
1.4
—
—
—
0
0
24
141
1.72
1.69
3.3
3.7
126.2
798.0
u/ml
0.67
24
135
36
236
1.55
1.67
5.1
3.3
—
—
—
0
0
250
2845
0.84
1.65
3.5
2.7
—
—
—
0
0
40
270
1.50
1.63
1.2
1.3
181.6
266.4
miu/ml
0.63
16
129
23
135
1.72
1.63
3.2
3.2
70.1
61.9
%
0.93
23
135
5
14
3.58
1.61
2.6
1.5
—
—
—
0
0
12
56
2.16
1.61
1.8
1.3
47.3
31.6
mmol/l
0.77
12
51
10
43
2.34
1.60
1.1
1.2
—
—
—
0
0
71
535
1.35
1.60
3.0
2.8
4.1
4.0
e9/l
0.07
59
428
15
78
1.94
1.54
9.6
3.1
—
—
—
0
0
20
115
1.75
1.53
1.2
1.0
—
—
—
0
0
62
462
1.36
1.51
3.2
3.3
4.5
4.6
pmol/l
0.35
57
407
16
87
1.85
1.46
1.5
1.2
—
—
—
0
0
5
16
3.14
1.44
1.0
1.2
—
—
—
0
0
118
1419
0.81
1.38
3.2
3.0
0.7
0.8
ug/l
0.21
80
927
83
658
1.29
1.35
1.5
1.4
—
—
—
0
0
21
128
1.65
1.34
1.0
1.1
—
—
—
0
0
7
150
0.46
1.32
1.6
1.2
—
—
—
0
0
6
24
2.51
1.30
1.0
1.5
—
—
—
0
0
15
85
1.78
1.23
2.7
2.2
—
—
—
0
0
234
2081
1.16
1.22
2.1
1.6
1.5
1.4
mmol/l
1.66
190
1751
19
116
1.65
1.22
1.3
1.2
—
—
—
0
0
10
188
0.53
1.21
1.5
1.5
—
—
—
0
0
7
142
0.49
1.21
3.1
1.7
—
—
—
0
0
8
38
2.11
1.18
1.1
1.0
—
—
—
0
0
11
57
1.94
1.17
10.3
3.1
—
—
—
0
0
5
20
2.51
1.15
1.0
1.1
—
—
—
0
0
770
7440
1.16
1.13
20.8
14.5
39.1
39.9
%
1.41
481
5429
10
183
0.54
1.12
1.4
1.4
—
—
—
0
0
7
30
2.34
1.12
4.7
2.3
28.7
31.4
umol/l
—
7
30
8
40
2.01
1.12
1.1
1.1
—
—
—
0
0
10
51
1.97
1.11
1.0
1.1
304.6
287.4
mg/l
—
10
44
10
182
0.54
1.11
1.4
1.4
—
—
—
0
0
13
75
1.74
1.03
1.6
1.5
284.3
283.9
mosm/kgh2o
0.02
13
56
12
68
1.77
1.00
1.3
1.1
—
—
—
0
0
21
139
1.52
1.00
1.1
1.1
1.9
2.4
u/ml
—
6
30
50
388
1.30
1.00
8.9
11.9
—
—
—
0
0
29
207
1.41
0.97
5.9
4.4
—
—
—
0
0
9
50
1.81
0.96
3.7
1.7
—
—
—
0
0
12
70
1.72
0.93
2.0
2.2
—
—
—
0
0
101
859
1.20
0.92
1.4
1.3
—
—
—
0
0
100
853
1.19
0.89
1.4
1.4
—
—
—
0
0
30
221
1.37
0.86
1.1
1.2
—
—
—
0
0
11
64
1.73
0.86
1.5
1.1
—
—
—
0
0
24
170
1.42
0.86
2.6
3.9
—
—
—
0
0
46
362
1.28
0.85
1.5
1.4
29.5
25.6
iu/l
0.33
40
300
61
499
1.24
0.83
3.1
2.7
—
—
—
0
0
8
46
1.75
0.82
2.0
3.0
—
—
—
0
0
12
73
1.65
0.82
1.6
1.4
—
—
—
0
0
43
338
1.28
0.81
2.1
1.8
—
—
—
0
0
30
224
1.35
0.80
1.3
1.7
46.6
40.1
nmol/l
0.69
30
213
13
82
1.59
0.78
1.2
1.0
—
—
—
0
0
6
34
1.77
0.76
1.3
1.4
5.3
6.4
mmol/l
—
6
34
6
34
1.77
0.76
1.2
1.3
—
—
—
0
0
10
59
1.70
0.76
1.0
1.1
—
—
—
0
0
12
75
1.61
0.75
1.4
1.6
—
—
—
0
0
5
24
2.09
0.74
1.0
1.1
—
—
—
0
0
42
334
1.27
0.74
1.6
1.6
—
—
—
0
0
60
498
1.22
0.73
1.2
1.2
—
—
—
0
0
7
39
1.80
0.72
2.1
3.3
—
—
—
0
0
17
117
1.46
0.72
1.1
1.0
8.2
4.3
u/ml
—
9
42
21
151
1.40
0.71
1.9
2.1
—
—
—
0
0
23
169
1.37
0.70
1.2
1.2
—
—
—
0
0
9
58
1.56
0.70
3.1
4.5
12.1
10.9
%
—
9
58
47
384
1.24
0.68
5.2
3.5
—
—
—
0
0
14
94
1.50
0.67
1.5
1.8
—
—
—
0
0
7
43
1.63
0.67
1.1
1.7
—
—
—
0
0
12
78
1.55
0.65
1.2
1.1
—
—
—
0
0
10
62
1.62
0.65
1.4
1.5
—
—
—
0
0
19
137
1.39
0.65
1.2
1.1
3.4
6.7
u/ml
0.55
14
75
67
571
1.19
0.64
1.1
1.2
124.0
146.6
iu/ml
0.15
19
226
10
63
1.59
0.62
1.1
1.4
—
—
—
0
0
18
130
1.39
0.61
1.1
1.5
—
—
—
0
0
18
131
1.38
0.59
1.4
1.2
—
—
—
0
0
10
65
1.54
0.55
2.5
3.3
57.4
59.4
%
—
5
43
43
360
1.20
0.52
1.6
1.6
—
—
—
0
0
9
65
1.39
0.50
1.3
1.2
—
—
—
0
0
43
362
1.20
0.50
1.6
1.6
—
—
—
0
0
87
776
1.13
0.49
1.8
1.4
—
—
—
0
0
22
172
1.29
0.48
3.3
3.8
—
—
—
0
0
24
190
1.27
0.48
1.5
1.2
—
—
—
0
0
11
76
1.45
0.48
1.0
1.1
—
—
—
0
0
14
102
1.38
0.47
1.1
1.0
9.1
3.9
u/ml
—
8
40
43
365
1.19
0.47
1.6
1.6
—
—
—
0
0
138
1272
1.10
0.45
3.6
2.9
4.7
2.5
e6/l
0.47
78
716
14
186
0.75
0.44
1.1
1.3
—
—
—
0
0
39
330
1.19
0.44
1.1
1.1
—
—
—
0
0
21
166
1.27
0.43
1.1
1.3
—
—
—
0
0
42
359
1.18
0.43
1.5
1.5
—
—
—
0
0
33
276
1.20
0.42
1.6
1.7
—
—
—
0
0
68
605
1.13
0.42
2.1
2.1
13.8
12.8
nmol/l
0.38
60
525
22
176
1.26
0.42
6.1
3.4
31.9
27.9
mg/l
0.19
16
103
21
167
1.26
0.42
1.2
1.8
—
—
—
0
0
0
15
0.00
0.41
0.0
9.1
—
—
—
0
0
5
35
1.43
0.39
2.2
1.6
—
—
—
0
0
9
69
1.31
0.37
1.4
1.4
6.7
6.8
mmol/l
—
9
64
29
244
1.19
0.36
1.9
2.3
—
—
—
0
0
34
291
1.17
0.36
3.3
3.5
6749.7
1395.4
u/ml
0.36
29
251
6
43
1.40
0.35
1.5
1.3
—
—
—
0
0
6
44
1.37
0.34
1.7
1.7
8.3
9.5
mmol/l
—
6
36
32
275
1.17
0.33
2.9
2.7
—
—
—
0
0
24
201
1.20
0.32
2.1
1.7
2.2
5.4
iu/l
—
9
67
256
2453
1.06
0.32
4.4
5.0
5.0
2.9
ug/l
0.30
231
2185
27
229
1.18
0.32
2.4
3.7
50.5
80.1
mg/l
0.52
21
189
10
132
0.76
0.32
1.1
1.1
—
—
—
0
0
84
773
1.09
0.31
3.4
4.3
12.1
28.9
ug/l
0.74
67
638
10
131
0.76
0.31
1.1
1.1
—
—
—
0
0
17
138
1.24
0.30
1.2
1.1
1.4
1.2
u/ml
—
8
64
7
55
1.27
0.30
3.3
2.2
3.2
2.2
ug/l
—
7
46
14
112
1.25
0.28
1.7
1.2
2.6
5.9
u/ml
—
8
47
11
85
1.30
0.28
5.4
3.8
—
—
—
0
0
8
64
1.25
0.27
2.0
1.6
0.9
1.0
g/l
—
8
64
16
131
1.23
0.27
1.7
1.2
—
—
—
0
0
34
301
1.13
0.25
1.8
1.6
—
—
—
0
0
69
639
1.09
0.24
1.2
1.2
—
—
—
0
0
5
40
1.25
0.22
1.6
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
3.3
—
—
—
0
0
0
12
0.00
0.21
0.0
2.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
0.9
—
0
7
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
5
43
1.16
0.21
1.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
26
230
1.13
0.20
2.5
3.7
31.2
44.7
mg/l
0.48
20
190
19
164
1.16
0.20
1.3
1.1
1.7
1.0
u/ml
—
9
68
30
334
0.90
0.20
1.1
1.1
—
—
—
0
0
12
99
1.21
0.19
1.3
1.2
—
—
—
0
0
11
90
1.22
0.19
1.6
2.0
—
—
—
0
0
5
66
0.76
0.17
1.8
1.3
—
—
—
0
0
15
173
0.87
0.17
3.1
2.2
—
—
—
0
0
8
70
1.14
0.16
1.0
1.1
—
—
—
0
0
18
158
1.14
0.16
1.3
1.8
209.6
209.2
pmol/l
0.00
18
149
6
79
0.76
0.15
3.0
2.5
—
—
—
0
0
7
86
0.81
0.14
1.0
1.2
—
—
—
0
0
7
87
0.80
0.14
1.3
1.1
—
—
—
0
0
5
47
1.06
0.09
3.0
2.3
414.2
494.1
min
—
5
32
232
2286
1.02
0.08
1.3
1.5
—
—
—
0
0
17
184
0.92
0.07
1.1
1.1
—
—
—
0
0
10
109
0.92
0.04
1.1
1.3
0.5
0.6
nmol/l
—
10
104
73
739
0.99
0.01
5.7
3.9
—
—
—
0
0
10
94
1.06
0.01
1.1
1.2
212.0
310.9
pmol/l
—
5
74
13
124
1.05
0.00
1.6
1.7
—
—
—
0
0
10
103
0.97
0.00
1.1
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
7.7
—
0
5
0
5
0.00
0.00
0.0
1.6
—
4.5
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
188.8
—
0
5
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
15.9
—
0
6
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
10
100
1.00
0.00
1.1
1.3
—
—
nmol/l
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint L12_EPIDERMTHICKNAS and mortality.

Females

Parameter HR [95% CI] p-value
L12_EPIDERMTHICKNAS 1.228 [1.06, 1.42] 0.007
Birth year 0.994 [0.99, 1.0] 0.146

During the follow-up period (1.1.1998 — 31.12.2019), 517 out of 3191 females with L12_EPIDERMTHICKNAS died.

Males

Parameter HR [95% CI] p-value
L12_EPIDERMTHICKNAS 1.233 [1.05, 1.44] 0.009
Birth year 0.988 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 555 out of 2752 males with L12_EPIDERMTHICKNAS died.

Mortality risk

Mortality risk for people of age

years, who have L12_EPIDERMTHICKNAS.

N-year risk Females Males
1 0.112% 0.254%
5 0.796% 1.429%
10 1.809% 3.74%
15 3.451% 7.347%
20 6.151% 12.246%

Relationships between endpoints

↥

Index endpoint: L12_EPIDERMTHICKNAS – Other and unspecified epidermal thickening

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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