erythema infectiosum: usually a benign childhood condition characterized by a classic slapped-cheek appearance (see the image below) and lacy exanthem.It results from infection with human parvovirus (PV) B19, an erythrovirus.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1130 |
4. Check minimum number of eventsNone |
1130 |
5. Include endpointsNone |
1130 |
6. Filter based on genotype QC (FinnGen only) |
1130 |
Control definitions (FinnGen only)
- Control exclude
- L12_URTICARIAERYTHEMA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L50-L54
- Name in latin
- Erythema nodosum
Similar endpoints
↥List of similar endpoints to
Erythema nodosum
based on the number of shared cases.
Similar with more cases:
- Urticaria and erythema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9004 | 6843 | 2116 |
| Only index persons | 7799 | 5941 | 1858 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.20 | 0.06 |
| Only index persons | 0.18 | 0.22 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 40.55 | 41.91 | 36.01 |
| Only index persons | 37.81 | 38.86 | 34.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1130 | 894 | 236 |
| Unadjusted period prevalence (%) | 0.26 | 0.30 | 0.10 |
| Median age at first event (years) | 38.61 | 38.20 | 40.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1018
- Matched controls
- 10180
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L52
ICD-10 Finland
Erythema nodosum
1597.8
323.0
603
9
69520
ICD-8 Finland
Erythematous condition, Erythema nodosum
+∞
257.5
236
*
6952A
ICD-9 Finland
Erythematous conditions, Erythema nodosum[ERYTHEMA NODOSUM ACUTUM]
+∞
100.7
95
*
M148, L529
ICD-10 Finland
NA
+∞
80.3
76
*
H02AB06
ATC
prednisolone; systemic
2.9
55.5
590
3307
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.8
48.5
178
432
M14.8*L52
ICD-10 Finland
Arthropathy in erythema: nodosum
+∞
36.7
35
*
L04AX01
ATC
azathioprine; systemic
5.9
35.9
105
194
L529
ICD-10 Finland
NA
+∞
35.6
34
*
M79.3
ICD-10 Finland
Panniculitis, unspecified
40.7
34.6
43
11
D86.0
ICD-10 Finland
Sarcoidosis of lung
13.6
33.2
58
45
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
31.4
465
2789
A46
ICD-10 Finland
Erysipelas
3.1
30.5
187
685
13597
ICD-8 Finland
Sarcoidosis, Suspecta
37.8
26.3
33
9
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
12.0
24.6
45
39
R50.9
ICD-10 Finland
Fever, unspecified
2.7
24.3
180
738
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
4.6
23.5
85
199
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
15.5
22.1
36
24
A07EC02
ATC
mesalazine; oral, rectal
3.7
19.9
91
265
H02AB07
ATC
prednisone; oral
2.4
18.7
171
781
J01MA02
ATC
ciprofloxacin; systemic
1.9
17.8
382
2486
K50.8
ICD-10 Finland
Other Crohn disease
7.7
17.8
41
55
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.8
17.2
115
439
132
Kela drug reimbursment
Sarcoidosis
14.4
16.9
28
20
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
16.3
356
2313
A02BC02
ATC
pantoprazole; systemic
1.7
15.8
647
5093
UJF32
NOMESCO Finland
Coloscopy
1.9
15.7
263
1551
J01FF01
ATC
clindamycin; systemic
1.9
15.3
291
1796
D86.1
ICD-10 Finland
Sarcoidosis of lymph nodes
10.6
14.8
28
27
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.1
14.6
191
1022
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
14.6
291
1821
J01DB01
ATC
cefalexin; oral
1.9
14.6
824
7071
K50.9
ICD-10 Finland
Crohn disease, unspecified
7.6
14.0
32
43
K51.5
ICD-10 Finland
Left sided colitis
4.6
14.0
48
108
1350A
ICD-9 Finland
Sarcoidosis[SARCOIDOSIS]
26.1
13.4
18
7
ZX120
NOMESCO Finland
Intravenous
2.5
13.3
111
479
TGC00
NOMESCO Finland
Bronchial lavation
4.7
12.9
43
94
R60.0
ICD-10 Finland
Localized oedema
2.3
12.8
122
567
K50.1
ICD-10 Finland
Crohn disease of large intestine
8.4
12.6
27
33
K50.0
ICD-10 Finland
Crohn disease of small intestine
7.1
12.2
29
42
UJF30
NOMESCO Finland
Ileoscopy through colon
2.3
11.8
111
511
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
12.7
11.7
20
16
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.1
11.6
140
719
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
4.0
11.6
45
115
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
11.6
195
1142
M13.9
ICD-10 Finland
Arthritis, unspecified
2.5
11.5
89
370
M14.8*D86.8
ICD-10 Finland
Arthropathy in sarcoidosis
121.3
11.4
12
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.2
11.3
117
563
J01DA01
ATC
[U] cefalexin; systemic
1.6
11.2
625
5105
E0000UV
ATC
NA
1.6
11.1
397
2897
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.5
11.1
50
146
D07AC01
ATC
betamethasone; topical
1.6
11.1
329
2289
M14.8
ICD-10 Finland
Arthropathies in other specified diseases classified elsewhere
43.8
10.9
13
*
A07EA06
ATC
budesonide; oral, local oral
3.5
10.7
49
145
M04AA01
ATC
allopurinol; systemic
2.2
10.2
103
490
H02AB04
ATC
methylprednisolone; systemic
2.0
10.2
147
809
I80.0
ICD-10 Finland
Phlebitis and thrombophlebitis of superficial vessels of lower extremities
3.2
10.0
52
170
SPAT1255
SPAT
Intravenous administration of medicine
2.6
9.8
72
289
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.9
9.8
59
213
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
9.8
191
1168
K50
ICD-10 Finland
Crohn disease [regional enteritis]
55.5
9.7
11
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.5
9.6
77
326
L50.9
ICD-10 Finland
Urticaria, unspecified
5.8
9.5
26
46
13599
ICD-8 Finland
Sarcoidosis, Unspecified
15.2
9.5
15
10
D86.2
ICD-10 Finland
Sarcoidosis of lung with sarcoidosis of lymph nodes
6.7
9.5
23
35
C03CA01
ATC
furosemide; systemic
1.7
9.3
238
1578
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
4.4
9.3
32
74
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
9.2
169
1012
J01MA12
ATC
levofloxacin; systemic
1.8
9.1
163
970
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.8
8.9
169
1023
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
3.1
8.8
46
151
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.5
8.8
67
278
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
2.2
8.7
85
399
TQW80
NOMESCO Finland
Local dermatologic skincare
3.9
8.7
34
89
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
10.1
8.5
16
16
D07AC13
ATC
mometasone; topical
1.6
8.5
267
1863
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.0
8.5
103
530
R03AC02
ATC
salbutamol; inhalant
1.5
8.3
505
4072
R06.0
ICD-10 Finland
Dyspnoea
1.6
8.3
224
1498
D86.3
ICD-10 Finland
Sarcoidosis of skin
14.6
8.2
13
9
SPAT1263
SPAT
Sampling
1.5
8.2
415
3220
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.0
8.1
105
555
K51.8
ICD-10 Finland
Other ulcerative colitis
4.9
8.1
25
52
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
7.9
354
2675
H02AB09
ATC
hydrocortisone; systemic
4.1
7.8
29
73
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.2
7.8
76
355
S18
ICPC
Laceration/cut
1.5
7.7
371
2838
A07EA02
ATC
hydrocortisone; rectal
3.7
7.6
31
85
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
2.6
7.6
52
204
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.4
7.4
61
264
L04AA06
ATC
mycophenolic acid; systemic
4.3
7.2
25
59
C03DA01
ATC
spironolactone; oral
2.0
7.2
94
499
J01AA02
ATC
doxycycline; systemic
1.5
7.2
736
6504
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
7.2
411
3247
SPAT1262
SPAT
Handing over of treatment supplies
1.7
7.2
154
967
M07.4*K50.9
ICD-10 Finland
Arthropathy in Crohn's disease [regional enteritis]
20.2
7.1
10
5
M30.0
ICD-10 Finland
Polyarteritis nodosa
20.2
7.1
10
5
L95.8
ICD-10 Finland
Other vasculitis limited to skin
12.1
7.1
12
10
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.5
7.1
258
1852
J01FA06
ATC
roxithromycin; oral
1.4
7.0
377
2939
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.5
7.0
231
1621
S97
ICPC
Chronic ulcer skin
2.5
6.9
53
223
P01AB01
ATC
metronidazole; oral, rectal
1.4
6.9
386
3029
L04AA01
ATC
[U] ciclosporin; systemic
4.7
6.7
21
45
D07AB08
ATC
desonide; topical
1.9
6.7
92
499
XG410
NOMESCO Finland
Flow-volume spirometry
2.7
6.6
43
164
R60.9
ICD-10 Finland
Oedema, unspecified
2.4
6.6
54
235
E000001
ATC
NA
1.6
6.6
190
1289
ZX108
NOMESCO Finland
Inhalation
8.8
6.6
13
15
M02.9
ICD-10 Finland
Reactive arthropathy, unspecified
4.2
6.5
23
56
XW000
NOMESCO Finland
Bone marrow biopsy
2.8
6.5
40
149
104
Kela drug reimbursment
Thyroid insufficiency
2.1
6.5
72
359
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
3.1
6.5
33
109
J01CA04
ATC
amoxicillin; systemic
1.5
6.5
788
7113
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.7
6.4
122
739
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.7
6.4
123
745
L50.3
ICD-10 Finland
Dermatographic urticaria
14.4
6.4
10
7
L50.8
ICD-10 Finland
Other urticaria
14.4
6.4
10
7
D07AD01
ATC
clobetasol; topical
1.7
6.3
140
885
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.5
6.3
46
189
M79.6
ICD-10 Finland
Pain in limb
1.4
6.3
333
2574
L03.9
ICD-10 Finland
Cellulitis, unspecified
3.7
6.3
25
68
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
9.3
6.3
12
13
L04AB04
ATC
adalimumab; parenteral
3.6
6.2
26
74
K51
ICD-10 Finland
Ulcerative colitis
6.3
6.2
15
24
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
5.8
6.2
16
28
E66.01
ICD-10 Finland
Obesity due to excess calories
1.9
6.1
84
456
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.5
6.1
212
1498
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
12.6
6.1
10
8
UKC02
NOMESCO Finland
Cystoscopy
1.7
6.1
115
693
N03AX16
ATC
pregabalin; oral
1.5
6.1
206
1451
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.6
6.0
146
946
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
231
387
7.25
137.45
2.9
2.0
40.6
39.6
u/l
0.27
212
348
179
238
8.75
130.35
2.8
2.2
11.4
11.9
mg/l
0.27
165
223
120
295
4.43
45.05
1.6
1.6
0.3
0.1
iu/ml
0.37
30
55
114
274
4.52
44.02
2.0
1.6
111.4
147.3
titre
—
7
11
251
1202
2.40
29.87
3.8
2.2
148.4
125.3
ug/g
0.47
210
929
88
254
3.67
26.27
1.9
1.6
0.2
0.2
g/l
0.03
83
242
66
156
4.43
25.88
1.2
1.2
—
—
—
0
0
89
267
3.53
25.07
1.8
1.6
1.2
1.2
g/l
0.19
84
251
61
143
4.45
24.16
1.3
1.2
270.5
252.3
u/ml
0.17
40
86
60
139
4.50
24.12
1.1
1.1
—
—
—
0
0
722
5414
1.92
23.77
12.8
8.6
4.2
4.0
e9/l
1.37
663
4748
622
4467
1.87
23.17
10.4
5.6
27.0
28.4
%
2.42
588
4156
33
45
7.52
22.99
1.2
1.1
179.3
197.1
iu/ml
0.13
33
45
60
145
4.31
22.86
6.2
5.5
704.8
334.8
iu/ml
—
10
17
615
4415
1.86
22.79
10.0
5.4
59.1
57.1
%
3.78
580
4128
860
6935
2.00
21.66
6.8
4.0
16.6
11.9
mm/h
11.89
814
6413
610
4418
1.83
21.47
8.2
6.1
1.2
1.2
mmol/l
0.12
513
3705
562
3988
1.81
21.00
6.9
5.4
1.2
1.2
mmol/l
0.16
516
3597
310
1873
1.90
19.07
1.7
1.5
—
—
—
0
0
178
894
2.18
18.24
5.1
4.0
258.1
251.3
u/l
0.15
167
848
533
3840
1.73
17.93
6.4
4.4
35.1
35.8
g/l
2.54
500
3583
859
7094
1.88
17.89
11.0
7.0
77.8
77.2
u/l
0.19
820
6658
343
2240
1.76
15.91
3.1
2.4
3508.9
5160.2
umol/l
0.37
300
1932
617
4720
1.68
15.90
6.8
5.7
10.0
10.8
umol/l
1.56
590
4472
323
2095
1.76
15.24
2.0
1.6
1.1
1.0
mg/l
0.16
251
1597
45
119
3.90
15.23
2.7
2.8
—
2589.5
—
0
11
233
1369
1.88
15.22
2.0
1.8
—
—
—
0
0
539
4013
1.66
15.17
2.9
2.3
76.8
77.3
nmol/l
0.16
500
3600
293
1851
1.79
15.12
2.8
2.4
6.4
7.4
e6/l
0.52
251
1646
132
633
2.23
15.06
1.6
1.6
—
—
—
0
0
759
6220
1.67
14.21
5.6
4.4
423.5
2230.8
e6/l
—
6
89
133
664
2.14
13.69
4.0
2.7
10.8
10.2
g/l
0.75
125
605
163
879
2.00
13.63
2.3
2.0
339.2
375.1
nmol/l
1.43
152
803
87
363
2.51
13.58
1.3
1.3
0.2
1.2
u/ml
0.78
15
28
65
235
2.87
13.42
2.7
2.7
—
—
—
0
0
347
2382
1.66
12.92
3.4
2.9
0.3
0.5
e6/l
2.23
270
1797
24
48
5.09
11.50
1.8
2.0
13.6
12.4
%
—
8
22
583
4627
1.54
11.23
4.7
3.6
0.0
0.0
estimate
0.00
134
877
71
297
2.48
11.04
1.8
1.8
—
—
—
0
0
326
2284
1.60
10.86
2.8
2.1
3.4
3.0
mg/l
1.46
284
1933
44
152
2.97
9.90
1.9
1.4
—
—
—
0
0
52
197
2.72
9.89
3.0
1.6
—
—
—
0
0
583
4708
1.49
9.82
4.6
3.6
0.0
0.0
estimate
0.50
137
861
22
47
4.75
9.79
2.1
2.1
—
—
—
0
0
53
204
2.68
9.78
1.6
1.5
—
—
—
0
0
184
1141
1.73
9.73
3.2
2.3
19.4
22.6
%
2.94
158
979
123
675
1.92
9.69
3.2
2.8
67.4
66.9
g/l
0.31
115
616
1023
9407
1.92
9.56
22.5
12.7
24.7
21.7
mg/l
2.01
891
7374
635
5241
1.48
9.44
5.1
4.4
6.7
6.6
mmol/l
0.97
596
4866
208
1349
1.66
9.29
3.1
2.3
11.6
13.1
umol/l
2.85
195
1234
61
259
2.43
9.21
1.3
1.2
4.4
11.6
u/ml
—
10
49
575
4671
1.47
9.15
6.0
4.9
0.0
0.0
estimate
0.50
137
877
60
256
2.42
8.97
1.3
1.2
3.1
2.5
u/ml
—
5
29
25
64
3.97
8.90
1.0
1.0
—
—
—
0
0
50
198
2.60
8.74
1.6
1.5
—
—
—
0
0
53
216
2.53
8.74
1.5
1.4
—
—
—
0
0
30
89
3.44
8.67
1.7
1.6
—
—
—
0
0
335
2483
1.50
8.27
5.5
3.9
0.0
0.0
estimate
0.39
137
867
189
1231
1.64
8.25
3.1
2.2
2.4
2.4
g/l
0.36
173
1131
56
242
2.38
8.16
3.2
3.9
59.3
43.5
mg/l
0.26
50
190
56
242
2.38
8.16
3.2
3.9
39.9
71.5
mg/l
0.60
50
190
536
4358
1.44
8.14
3.6
2.7
111.6
99.4
ug/l
0.58
513
4023
39
142
2.81
8.03
1.6
1.5
—
—
—
0
0
454
3603
1.43
7.76
2.2
1.9
95.2
96.6
pmol/l
0.22
235
1826
353
2686
1.46
7.50
3.5
3.1
7.3
7.3
mmol/l
0.00
298
2255
167
1082
1.64
7.41
7.3
4.8
1.0
1.0
mmol/l
0.10
157
998
53
234
2.33
7.39
1.5
1.5
—
—
—
0
0
20
50
4.05
7.36
1.9
1.8
447.7
490.7
e6/l
0.16
15
43
46
192
2.46
7.26
1.6
1.7
12563.3
14439.4
e6/l
0.12
37
140
231
1624
1.53
7.22
1.9
1.7
1231.7
1213.4
nmol/l
0.10
188
1210
150
952
1.66
7.21
2.0
1.8
—
—
—
0
0
16
34
4.76
7.18
3.6
2.2
33.8
271.4
ug/l
0.46
16
28
45
188
2.45
7.09
4.9
3.8
61.8
58.0
%
1.32
45
188
70
353
2.05
7.04
1.8
1.9
1.6
1.5
g/l
0.26
61
310
450
3612
1.41
7.02
4.9
3.8
—
—
—
0
0
65
319
2.10
7.02
3.1
2.1
3.9
3.7
g/l
0.54
52
239
65
320
2.09
6.97
3.1
2.1
7.6
7.5
g/l
0.21
54
249
65
320
2.09
6.97
3.1
2.1
—
—
—
0
0
32
114
2.86
6.89
1.7
1.6
—
—
—
0
0
11
17
6.52
6.78
1.2
1.1
—
—
—
0
0
11
17
6.52
6.78
1.2
1.1
99.0
101.1
%
0.08
11
17
366
2847
1.42
6.77
2.8
2.4
62.4
56.6
u/l
0.39
344
2621
299
2241
1.45
6.77
1.4
1.3
2.0
1.7
u/ml
0.12
82
605
1024
9585
1.73
6.72
21.4
14.5
3.9
3.9
mmol/l
0.38
999
9310
147
947
1.63
6.66
2.0
1.7
—
—
—
0
0
43
182
2.42
6.61
4.4
3.6
4.3
4.2
e9/l
0.11
43
182
61
300
2.09
6.57
3.2
2.1
3.1
3.1
g/l
0.05
53
244
102
598
1.78
6.53
1.5
1.2
229.5
199.0
u/ml
0.13
94
547
40
165
2.48
6.49
1.3
1.6
—
—
—
0
0
61
302
2.08
6.46
2.5
2.1
10.6
10.3
g/l
0.16
56
263
86
481
1.85
6.42
4.0
3.4
5.2
5.1
kpa
0.10
80
455
239
1731
1.48
6.41
1.3
1.3
36.2
33.9
iu/ml
0.07
74
540
17
42
4.09
6.37
1.5
1.6
—
—
—
0
0
17
42
4.09
6.37
1.5
1.6
—
—
—
0
0
1020
9562
1.69
6.34
21.1
14.4
139.6
139.6
mmol/l
0.33
996
9304
155
1024
1.60
6.33
3.8
2.4
6.6
7.8
umol/l
0.49
132
869
66
340
2.00
6.28
1.9
1.9
—
—
—
0
0
126
792
1.67
6.28
2.6
2.1
0.2
0.2
g/l
0.55
114
745
113
696
1.69
6.08
4.7
5.7
1.2
1.3
mmol/l
0.55
108
669
130
832
1.64
6.04
2.3
2.3
35.3
37.8
u/l
0.12
107
697
61
310
2.02
6.04
1.7
1.8
—
—
—
0
0
32
123
2.65
6.01
2.7
2.6
0.8
1.2
%
0.79
27
96
394
3158
1.38
5.96
3.4
3.3
2.4
2.4
mmol/l
0.25
343
2774
81
456
1.84
5.93
3.9
3.3
2.0
1.8
mmol/l
0.13
64
342
35
142
2.51
5.90
1.5
1.3
116.5
112.1
u/ml
—
5
29
228
1663
1.46
5.86
1.4
1.2
9.0
12.1
u/ml
0.29
86
636
1052
9981
1.78
5.78
14.9
9.7
24.7
24.9
u/l
0.17
1015
9638
333
2608
1.39
5.76
4.7
3.9
7.5
8.4
mg/mmol
0.14
206
1594
55
275
2.05
5.70
3.0
2.3
0.5
0.9
g/l
0.44
49
247
196
1397
1.49
5.65
4.2
3.1
0.8
0.8
mmol/l
0.24
187
1308
197
1410
1.48
5.56
3.0
2.6
1.0
1.2
e6/l
0.22
121
780
836
7582
1.39
5.56
4.7
4.2
14.7
14.7
pmol/l
0.03
767
6923
11
21
5.28
5.53
2.5
2.1
—
—
—
0
0
29
111
2.66
5.51
1.6
1.4
—
—
—
0
0
38
166
2.33
5.49
1.5
1.4
—
—
—
0
0
38
166
2.33
5.49
1.5
1.4
—
—
—
0
0
304
2364
1.39
5.44
3.8
2.9
2057.1
1143.6
ng/l
0.62
257
1983
378
3046
1.36
5.43
3.8
3.0
30.0
30.6
u/l
0.17
360
2904
46
221
2.13
5.31
1.2
1.2
27.8
36.4
u/ml
—
5
23
405
3308
1.35
5.30
4.2
3.4
34.4
43.0
ng/l
0.28
266
2129
115
743
1.61
5.15
4.5
3.2
2.1
2.1
mmol/l
0.02
94
598
35
153
2.33
5.07
1.5
1.4
—
—
—
0
0
21
71
2.99
5.00
1.9
2.5
61.6
57.9
%
0.30
14
47
114
749
1.58
4.77
4.5
3.2
5.9
5.8
kpa
0.45
107
726
250
1921
1.39
4.74
1.9
1.7
419.9
34069837.6
pmol/l
2.16
209
1585
47
240
2.00
4.65
1.5
1.3
—
—
—
0
0
15
43
3.52
4.62
1.1
1.0
—
—
—
0
0
69
404
1.75
4.49
5.6
8.0
24.6
24.4
mmol/l
0.31
63
380
18
60
3.03
4.41
2.1
1.8
599.2
770.6
e6/l
—
9
23
17
56
3.07
4.25
1.3
1.2
—
—
—
0
0
179
1322
1.42
4.25
2.6
1.9
29.8
29.4
s
0.30
174
1275
23
90
2.59
4.23
1.3
1.4
—
—
—
0
0
177
1308
1.42
4.18
3.3
2.8
5.7
3.7
e6/l
1.04
101
682
47
251
1.91
4.12
1.2
1.2
—
—
—
0
0
130
909
1.49
4.11
5.4
7.3
1.1
1.3
mmol/l
0.25
109
725
10
23
4.38
4.09
2.7
1.7
—
—
—
0
0
257
2032
1.34
4.01
5.2
3.9
1.0
1.0
kg/l
0.30
45
278
32
150
2.17
3.99
1.3
1.2
5.5
3.8
u/ml
0.18
15
43
141
1009
1.45
3.97
30.7
22.4
1.3
1.2
inr
0.04
30
141
703
6367
1.28
3.78
3.4
3.2
—
—
—
0
0
18
66
2.76
3.76
2.7
1.5
—
—
—
0
0
39
202
1.96
3.76
1.2
1.3
—
—
—
0
0
109
750
1.50
3.74
4.2
3.5
1.2
1.2
mmol/l
0.61
96
636
9
16
5.66
3.66
1.1
1.1
—
—
—
0
0
259
2076
1.32
3.65
1.6
1.5
18.9
21.6
nmol/l
2.46
220
1769
214
1668
1.35
3.65
2.6
2.8
2.5
2.5
mmol/l
0.48
192
1467
938
8845
1.36
3.61
5.7
5.0
1.9
2.0
mu/l
0.37
876
8149
26
117
2.25
3.59
1.2
1.4
—
—
—
0
0
94
633
1.53
3.57
2.6
3.5
4.4
4.5
pmol/l
0.41
87
558
31
151
2.08
3.54
1.1
1.3
—
—
—
0
0
935
8821
1.35
3.52
18.3
11.7
83.4
83.0
ml/min/173m2
0.20
803
7219
43
236
1.85
3.51
1.3
1.1
—
—
—
0
0
18
69
2.63
3.48
1.1
1.0
—
—
—
0
0
26
119
2.21
3.46
1.2
1.3
—
—
—
0
0
26
119
2.21
3.46
1.2
1.3
—
—
—
0
0
48
276
1.77
3.39
1.5
1.2
—
—
—
0
0
19
78
2.46
3.22
1.3
1.5
—
—
—
0
0
317
2650
1.27
3.21
2.4
2.1
113.5
199.1
u/l
2.67
296
2510
22
97
2.29
3.21
1.0
1.2
44.0
57.2
u/l
1.44
14
70
165
1262
1.36
3.18
2.4
2.1
—
—
—
0
0
25
117
2.16
3.18
1.2
1.3
—
—
—
0
0
25
117
2.16
3.18
1.2
1.3
—
—
—
0
0
25
118
2.14
3.12
1.2
1.3
—
—
—
0
0
25
118
2.14
3.12
1.2
1.3
—
—
—
0
0
23
105
2.22
3.10
1.9
1.7
65.0
61.4
%
0.19
17
72
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
40
225
1.81
3.06
4.2
2.5
0.4
0.4
u/ml
0.10
26
125
7
12
5.86
3.02
2.4
1.8
—
—
—
0
0
60
380
1.61
3.00
5.2
3.2
24.3
24.4
mmol/l
0.04
54
341
35
190
1.87
2.99
3.5
2.7
25.4
25.0
mmol/l
0.18
28
168
5
5
10.04
2.98
1.4
1.2
—
—
—
0
0
150
1144
1.36
2.95
2.1
1.9
—
—
—
0
0
25
121
2.09
2.94
1.1
1.1
—
—
—
0
0
101
720
1.44
2.94
4.5
3.4
83.7
80.4
ng/l
0.15
87
623
76
512
1.52
2.92
1.5
1.5
—
—
—
0
0
95
670
1.46
2.92
2.8
2.8
215.5
181.3
ng/l
0.27
80
609
27
135
2.02
2.92
1.2
1.4
—
—
—
0
0
849
7967
1.26
2.91
24.2
15.6
13.9
13.6
%
4.40
831
7805
265
2191
1.27
2.91
3.5
2.1
—
—
—
0
0
123
916
1.38
2.80
3.6
3.2
—
—
—
0
0
101
728
1.43
2.78
1.3
1.2
201.1
156.4
iu/ml
0.45
42
284
9
23
3.94
2.77
1.0
1.1
—
—
—
0
0
26
131
2.01
2.77
1.0
1.1
—
—
—
0
0
29
153
1.92
2.72
1.3
1.2
2.6
5.3
u/ml
0.79
17
59
88
623
1.45
2.67
3.8
2.6
4.3
4.6
kpa
0.73
82
600
677
6231
1.22
2.63
3.4
2.9
43.3
44.6
u/l
0.24
635
5830
68
462
1.50
2.54
1.9
1.7
—
—
—
0
0
6
11
5.48
2.54
1.0
2.9
0.5
0.6
u/field
—
6
11
16
69
2.34
2.49
1.6
2.0
2.5
2.3
u/field
0.07
11
33
1078
10515
1.55
2.48
30.3
19.0
264.4
257.0
e9/l
2.83
1052
10259
201
1637
1.28
2.48
4.2
3.5
586.1
311.9
ng/l
0.37
148
1183
139
1077
1.33
2.48
9.0
6.6
—
—
—
0
0
24
123
1.97
2.46
1.2
1.3
—
—
—
0
0
14
57
2.47
2.45
1.5
1.3
3787.1
174418.1
e6/l
—
7
30
1078
10522
1.53
2.39
30.3
19.0
4.4
4.5
e12/l
0.96
1049
10247
1078
10525
1.53
2.35
30.3
19.0
6.9
6.6
e9/l
2.68
1050
10243
1078
10527
1.52
2.32
30.5
19.1
131.7
133.9
g/l
5.24
1061
10380
15
65
2.33
2.32
1.2
1.5
—
—
—
0
0
75
532
1.44
2.29
1.4
1.3
24.3
29.0
iu/l
0.67
64
459
16
74
2.18
2.15
1.4
1.1
—
—
—
0
0
16
74
2.18
2.15
1.4
1.1
—
—
—
0
0
12
49
2.46
2.11
1.2
1.3
—
—
—
0
0
16
75
2.15
2.09
1.4
1.1
—
—
—
0
0
16
75
2.15
2.09
1.4
1.1
—
—
—
0
0
16
75
2.15
2.09
1.4
1.1
—
—
—
0
0
9
31
2.92
2.07
2.6
1.4
—
—
—
0
0
5
10
5.02
2.07
1.2
2.7
—
—
—
0
0
91
682
1.36
2.05
3.4
2.3
5.0
6.3
ug/l
0.52
71
603
16
76
2.12
2.03
1.3
1.4
—
—
—
0
0
16
76
2.12
2.03
1.3
1.4
—
—
—
0
0
16
76
2.12
2.03
1.3
1.4
—
—
—
0
0
12
50
2.42
2.03
1.2
1.3
—
—
—
0
0
20
105
1.92
1.96
1.0
1.1
—
—
—
0
0
92
697
1.35
1.94
2.4
2.4
64.5
68.0
ml/min/173m2
0.44
41
291
53
364
1.48
1.94
4.8
3.5
47.4
48.6
%
0.13
53
359
67
911
0.72
1.88
1.6
1.6
—
—
—
0
0
80
597
1.37
1.87
2.0
1.8
—
—
—
0
0
39
253
1.56
1.86
1.5
1.3
13.1
10.6
u/l
0.52
31
206
28
167
1.69
1.85
1.7
1.5
50.4
43.0
nmol/l
0.29
28
161
26
152
1.73
1.84
1.0
1.0
3.3
1.9
u/ml
—
10
77
6
17
3.54
1.84
1.0
1.0
—
—
—
0
0
5
12
4.18
1.82
2.4
1.3
—
—
—
0
0
18
94
1.93
1.80
3.2
3.5
—
—
—
0
0
20
109
1.85
1.78
4.9
5.4
12.6
11.8
mg/l
0.33
20
99
882
8450
1.20
1.77
6.3
5.4
40.4
39.3
mmol/mol
2.28
826
7849
481
4397
1.16
1.75
5.4
3.9
—
—
—
0
0
8
30
2.68
1.72
3.5
4.8
—
—
—
0
0
15
76
1.99
1.64
1.0
1.4
—
—
—
0
0
5
14
3.58
1.61
1.0
1.1
—
—
—
0
0
16
84
1.92
1.60
29.2
8.8
6.9
6.8
mmol/l
0.08
11
63
44
305
1.46
1.58
1.2
1.1
—
—
—
0
0
13
64
2.04
1.54
1.2
1.4
—
—
—
0
0
18
100
1.81
1.53
1.6
1.9
33.5
32.3
pg
0.44
18
100
5
15
3.34
1.52
1.2
1.0
—
—
—
0
0
5
15
3.34
1.52
1.4
1.3
—
—
—
0
0
10
45
2.23
1.46
1.4
1.4
—
—
—
0
0
10
45
2.23
1.46
1.4
1.4
—
—
—
0
0
10
45
2.23
1.46
1.4
1.4
—
—
—
0
0
10
45
2.23
1.46
1.1
1.2
—
—
—
0
0
10
45
2.23
1.46
1.4
1.4
—
—
—
0
0
24
148
1.64
1.45
1.1
1.1
—
—
—
0
0
43
304
1.43
1.42
1.2
1.1
—
—
—
0
0
27
173
1.57
1.41
2.4
2.1
117.4
129.2
g/l
0.68
16
132
7
29
2.42
1.39
1.9
1.4
15.2
8.4
ug/l
—
7
29
12
60
2.01
1.38
1.2
1.3
—
—
—
0
0
12
60
2.01
1.38
1.0
1.2
—
—
—
0
0
11
54
2.05
1.33
1.2
1.4
—
275.0
—
0
6
12
61
1.98
1.33
1.1
1.1
1.0
1.1
ratio
—
5
28
9
45
2.01
1.23
1.1
1.2
—
—
—
0
0
11
57
1.94
1.17
1.1
1.2
—
—
—
0
0
105
876
1.22
1.12
3.5
3.9
17.6
21.7
ug/l
0.09
78
713
10
51
1.97
1.11
1.1
1.1
—
—
—
0
0
10
51
1.97
1.11
1.2
1.3
—
60.0
—
0
5
24
160
1.51
1.10
3.8
3.2
0.8
0.9
nmol/l
0.75
19
127
37
269
1.39
1.09
1.4
1.4
248.5
287.7
ug/g
0.58
19
158
5
21
2.39
1.09
1.0
1.0
29.6
24.2
u/ml
—
5
21
43
321
1.35
1.09
2.0
1.6
—
—
—
0
0
45
339
1.34
1.08
1.3
1.3
212.8
230.7
miu/ml
0.10
18
160
71
571
1.26
1.06
1.2
1.3
—
—
—
0
0
7
33
2.13
1.05
1.6
1.5
—
—
—
0
0
7
33
2.13
1.05
1.6
1.5
—
—
—
0
0
23
336
0.68
1.05
1.4
1.5
—
—
—
0
0
12
67
1.80
1.05
1.2
1.1
—
—
—
0
0
21
311
0.67
1.03
1.4
1.4
—
—
—
0
0
21
311
0.67
1.03
1.4
1.4
—
—
—
0
0
21
311
0.67
1.03
1.4
1.4
—
—
—
0
0
13
75
1.74
1.03
1.5
1.1
—
—
—
0
0
7
34
2.07
1.03
1.4
1.5
—
—
—
0
0
21
310
0.67
1.02
1.4
1.4
—
—
—
0
0
15
91
1.66
1.00
1.1
1.2
—
—
—
0
0
928
9043
1.15
1.00
4.8
4.3
6.0
5.9
mmol/l
1.36
857
8249
25
172
1.46
1.00
1.2
1.1
0.5
1.6
u/ml
1.09
12
62
18
115
1.57
1.00
1.1
1.1
1.1
7.4
u/ml
2.01
11
38
20
133
1.51
0.94
1.4
1.3
0.5
0.6
nmol/l
0.46
20
127
7
37
1.90
0.94
1.1
1.2
—
—
—
0
0
7
37
1.90
0.94
1.1
1.2
—
—
—
0
0
9
52
1.74
0.92
1.1
1.3
—
—
—
0
0
20
134
1.50
0.92
1.4
1.3
—
0.3
nmol/l
—
0
8
13
206
0.63
0.89
3.6
3.7
54.5
34.2
u/ml
0.29
13
200
90
765
1.19
0.83
2.2
1.8
—
—
—
0
0
6
33
1.82
0.79
1.0
1.4
—
—
—
0
0
23
165
1.40
0.78
2.3
2.2
16.2
15.9
%
0.10
12
71
0
27
0.00
0.77
0.0
1.2
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
9
55
1.64
0.73
1.0
1.2
—
—
—
0
0
264
2444
1.10
0.72
1.8
1.6
1.4
1.4
mmol/l
0.15
217
2073
16
109
1.47
0.71
3.5
1.9
3.4
5.5
u/ml
0.73
16
102
126
1119
1.14
0.70
4.5
4.3
32.4
32.9
%
0.21
98
746
7
41
1.71
0.70
1.6
1.2
—
—
—
0
0
124
1101
1.14
0.69
1.4
1.7
1.5
1.4
%
0.27
105
977
12
77
1.56
0.68
2.5
2.1
—
—
—
0
0
151
1366
1.12
0.64
4.8
4.7
2.9
2.3
ug/l
0.43
133
1222
19
138
1.38
0.62
6.9
5.8
307.9
379.6
umol/l
1.19
19
122
8
49
1.64
0.62
1.0
1.2
—
—
—
0
0
16
113
1.42
0.61
1.6
1.4
420.1
326.9
pmol/l
0.41
11
85
0
23
0.00
0.58
0.0
1.1
—
—
—
0
0
34
274
1.25
0.57
1.6
1.9
7.8
5.3
iu/l
—
10
100
11
73
1.51
0.56
2.6
1.7
—
—
—
0
0
37
303
1.23
0.55
2.5
3.0
104.4
757.4
u/ml
0.80
29
262
27
213
1.27
0.54
1.1
1.3
3.8
3.8
mmol/l
0.03
27
196
6
39
1.54
0.53
1.0
1.2
—
—
—
0
0
48
406
1.19
0.52
2.9
2.0
12.7
12.0
nmol/l
0.15
42
362
31
380
0.81
0.51
1.6
1.4
—
—
—
0
0
26
206
1.27
0.51
2.0
2.4
47.6
121.4
ug/min
1.00
14
127
9
65
1.39
0.50
1.2
1.6
12.9
11.6
umol/l
—
9
60
17
129
1.32
0.46
1.2
1.2
—
—
—
0
0
21
166
1.27
0.43
1.6
1.6
—
—
—
0
0
11
78
1.41
0.43
1.4
1.5
0.9
1.0
g/l
0.44
11
78
10
70
1.43
0.41
1.1
1.2
—
—
—
0
0
49
426
1.16
0.41
1.6
1.4
—
—
—
0
0
5
34
1.47
0.40
1.0
1.0
—
—
—
0
0
50
437
1.15
0.40
2.3
2.1
8398.2
3923.5
u/l
0.43
19
185
9
69
1.31
0.37
1.1
1.1
—
—
—
0
0
25
207
1.21
0.36
1.4
1.5
—
—
—
0
0
9
70
1.29
0.36
1.0
1.1
—
—
—
0
0
6
42
1.43
0.35
1.7
3.0
—
—
—
0
0
13
99
1.32
0.35
1.3
1.1
—
—
—
0
0
6
43
1.40
0.35
1.3
1.5
—
—
—
0
0
6
45
1.34
0.33
1.2
1.2
31.0
32.9
nmol/l
—
6
38
10
74
1.35
0.32
1.4
1.3
1.9
1.5
nmol/l
—
10
65
52
579
0.89
0.31
1.5
1.5
—
—
—
0
0
70
639
1.10
0.30
2.1
3.1
55.4
60.0
u/ml
0.06
65
616
29
250
1.16
0.29
1.8
1.7
—
—
—
0
0
117
1096
1.08
0.29
3.9
4.2
24.0
21.1
%
0.68
49
484
8
65
1.23
0.27
1.4
1.8
—
—
—
0
0
32
281
1.14
0.26
1.5
1.6
—
—
—
0
0
9
72
1.25
0.25
2.2
2.5
—
—
—
0
0
16
134
1.20
0.23
1.2
1.4
7.8
7.3
mmol/l
—
10
95
5
39
1.28
0.23
1.0
1.1
2167.4
1819.5
miu/ml
—
5
39
211
2033
1.05
0.22
1.5
1.4
—
—
—
0
0
5
42
1.19
0.21
1.0
2.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
20
173
1.16
0.21
1.3
1.5
—
—
—
0
0
11
89
1.24
0.21
1.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
880
8727
1.04
0.19
20.7
13.7
39.3
39.5
%
0.47
620
6435
946
9396
1.04
0.18
4.9
4.7
2.8
2.8
mmol/l
0.87
878
8686
914
9204
0.96
0.17
4.4
4.2
1.5
1.5
mmol/l
2.58
843
8504
10
82
1.22
0.17
1.2
1.2
0.5
0.9
u/ml
—
5
32
28
253
1.11
0.17
1.1
1.2
—
—
—
0
0
44
410
1.08
0.15
1.4
1.4
—
—
—
0
0
882
8879
0.97
0.15
4.0
3.8
1.3
1.3
mmol/l
1.20
809
8149
18
163
1.11
0.10
1.4
1.4
0.2
0.3
nmol/l
0.92
12
136
35
372
0.94
0.10
1.6
1.7
—
—
—
0
0
54
517
1.05
0.09
1.1
1.0
—
—
—
0
0
42
400
1.05
0.08
2.6
1.7
4.2
3.0
mg/l
0.59
34
283
33
313
1.06
0.07
2.0
1.6
—
—
—
0
0
77
789
0.97
0.06
2.9
2.9
1.0
0.7
ug/l
0.98
48
498
35
338
1.04
0.04
4.9
6.7
1.6
1.6
%
0.12
35
319
925
9237
1.01
0.02
4.5
4.2
4.7
4.8
mmol/l
1.33
855
8584
12
113
1.06
0.02
1.6
1.9
90.1
90.4
%
0.09
12
113
0
8
0.00
0.00
0.0
1.1
—
6.7
—
0
8
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
6
67
0.89
0.00
18.5
11.6
0.6
0.6
mmol/l
—
6
60
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
4.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
13.2
—
0
6
6
67
0.89
0.00
1.5
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_ERYTHEMANODOSUM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ERYTHEMANODOSUM | 1.225 [1.06, 1.41] | 0.005 |
| Birth year | 0.99 [0.98, 1.0] | 0.027 |
During the follow-up period (1.1.1998 — 31.12.2019), 380 out of 3301 females with L12_ERYTHEMANODOSUM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ERYTHEMANODOSUM | 1.581 [1.26, 1.98] | < 0.001 |
| Birth year | 0.984 [0.97, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 148 out of 1122 males with L12_ERYTHEMANODOSUM died.
Mortality risk
Mortality risk for people of age
years, who have L12_ERYTHEMANODOSUM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.106% | 0.252% |
| 5 | 0.531% | 1.652% |
| 10 | 1.452% | 4.087% |
| 15 | 2.738% | 7.634% |
| 20 | 5.092% | 12.892% |
Relationships between endpoints
↥Index endpoint: L12_ERYTHEMANODOSUM – Erythema nodosum
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data