Erythema nodosum

L12_ERYTHEMANODOSUM

erythema infectiosum: usually a benign childhood condition characterized by a classic slapped-cheek appearance (see the image below) and lacy exanthem.It results from infection with human parvovirus (PV) B19, an erythrovirus.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L52
  • Hospital discharge: ICD-9 6952
  • Hospital discharge: ICD-8 69520
  • Cause of death: ICD-10 L52
  • Cause of death: ICD-9 6952
  • Cause of death: ICD-8 69520

2 out of 7 registries used, show all original rules.

1153

4. Check minimum number of events

None

1153

5. Include endpoints

None

1153

6. Filter based on genotype QC (FinnGen only)

1117

Control definitions (FinnGen only)

Control exclude
L12_URTICARIAERYTHEMA

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L50-L54
Name in latin
Erythema nodosum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 9004 6843 2116
Only index persons 7799 5941 1858
Unadjusted period prevalence (%)
Whole population 0.16 0.20 0.06
Only index persons 0.18 0.22 0.07
Median age at first event (years)
Whole population 40.55 41.91 36.01
Only index persons 37.81 38.86 34.46

-FinnGen-

Key figures

All Female Male
Number of individuals 1117 882 235
Unadjusted period prevalence (%) 0.27 0.31 0.11
Median age at first event (years) 38.96 38.48 40.73

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1153
Matched controls
11530
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L52
ICD-10 Finland
Erythema nodosum
1420.1
307.7
688
12
69520
ICD-8 Finland
Erythematous condition, Erythema nodosum
+∞
291.4
267
*
6952A
ICD-9 Finland
Erythematous conditions, Erythema nodosum[ERYTHEMA NODOSUM ACUTUM]
+∞
111.3
105
*
M148, L529,
ICD-10 Finland
+∞
90.8
86
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.6
75.0
205
521
L04AX01
ATC
azathioprine; systemic
6.5
70.0
121
204
D86.0
ICD-10 Finland
Sarcoidosis of lung
13.0
65.4
64
52
H02AB06
ATC
prednisolone; systemic
2.8
64.6
688
3947
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
17.0
61.9
52
32
A46
ICD-10 Finland
Erysipelas
3.3
51.9
234
828
M79.3
ICD-10 Finland
Panniculitis, unspecified
59.2
43.7
51
9
M14.8*L52
ICD-10 Finland
Arthropathy in erythema: nodosum
+∞
41.9
40
*
L529, ,
ICD-10 Finland
+∞
39.8
38
*
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
11.5
39.1
41
37
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
37.7
574
3569
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
4.4
37.4
98
237
K50.8
ICD-10 Finland
Other Crohn disease
7.4
31.5
46
64
13597
ICD-8 Finland
Sarcoidosis, Suspecta
42.4
30.1
37
9
A07EC02
ATC
mesalazine; oral, rectal
3.7
29.7
101
295
D86.1
ICD-10 Finland
Sarcoidosis of lymph nodes
11.8
29.2
30
26
132
Kela drug reimbursment
Sarcoidosis
11.0
28.8
31
29
R50.9
ICD-10 Finland
Fever, unspecified
2.4
25.9
211
990
H02AB07
ATC
prednisone; oral
2.4
24.8
196
907
R60.0
ICD-10 Finland
Localized oedema
2.5
22.7
165
733
K50.1
ICD-10 Finland
Crohn disease of large intestine
7.5
22.1
32
44
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
8.7
22.0
28
33
J01FF01
ATC
clindamycin; systemic
1.9
21.5
340
2045
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
4.1
21.2
59
149
TGC00
NOMESCO Finland
Bronchial lavation
4.9
21.2
47
99
K51.5
ICD-10 Finland
Left sided colitis
4.4
20.6
53
126
J01MA02
ATC
ciprofloxacin; systemic
1.8
20.5
446
2960
K50.9
ICD-10 Finland
Crohn disease, unspecified
5.6
20.3
39
72
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.4
20.3
158
722
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.3
20.0
76
238
A02BC02
ATC
pantoprazole; systemic
1.8
19.8
794
6292
I80.0
ICD-10 Finland
Phlebitis and thrombophlebitis of superficial vessels of lower extremities
3.5
19.0
66
195
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.0
18.8
257
1462
M13.9
ICD-10 Finland
Arthritis, unspecified
2.6
18.7
111
447
UJF32
NOMESCO Finland
Coloscopy
1.9
18.6
311
1893
UJF30
NOMESCO Finland
Ileoscopy through colon
2.4
18.5
140
632
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.4
18.3
132
583
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.2
18.0
164
800
D86.2
ICD-10 Finland
Sarcoidosis of lung with sarcoidosis of lymph nodes
7.4
17.9
26
36
SPAT1255
SPAT
Intravenous administration of medicine
2.8
17.4
89
331
D07AC01
ATC
betamethasone; topical
1.7
17.4
419
2836
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
17.4
420
2845
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
16.7
343
2210
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.6
16.7
55
157
TQW80
NOMESCO Finland
Local dermatologic skincare
4.4
16.5
42
99
E0000UV, ,
ATC
1.7
15.9
495
3569
L04AA06
ATC
mycophenolic acid; systemic
5.1
15.8
33
66
K51.8
ICD-10 Finland
Other ulcerative colitis
5.4
15.7
31
59
C03CA01
ATC
furosemide; systemic
1.8
15.6
311
1983
M14.8
ICD-10 Finland
Arthropathies in other specified diseases classified elsewhere
162.1
15.5
16
*
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
2.4
14.9
106
464
M04AA01
ATC
allopurinol; systemic
2.2
14.9
129
615
ZX120
NOMESCO Finland
Intravenous
2.3
14.8
125
590
TPH04
NOMESCO Finland
Cathetrisation of vein
1.8
14.4
249
1517
A07EA06
ATC
budesonide; oral, local oral
3.1
14.0
58
192
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
2.9
13.8
65
231
J01DB01
ATC
cefalexin; oral
1.8
13.8
948
8255
H02AB04
ATC
methylprednisolone; systemic
2.0
13.7
173
950
L04AX03
ATC
methotrexate; systemic
2.1
13.5
130
647
J01DA01
ATC
[U] cefalexin
1.6
13.4
714
5786
1350A
ICD-9 Finland
Sarcoidosis[SARCOIDOSIS]
18.5
13.4
20
11
K50.0
ICD-10 Finland
Crohn disease of small intestine
4.5
13.4
32
72
SPAT1263
SPAT
Sampling
1.6
12.9
478
3547
L04AA01
ATC
[U] ciclosporin
5.8
12.8
23
40
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.4
12.7
93
412
A07EA02
ATC
hydrocortisone; rectal
4.1
12.7
35
88
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
4.0
12.3
35
90
H02AB09
ATC
hydrocortisone; systemic
3.7
12.2
39
109
R60.9
ICD-10 Finland
Oedema, unspecified
2.6
12.1
73
296
127
Kela drug reimbursment
Transplant complication
5.2
11.8
24
47
M14.8*D86.8
ICD-10 Finland
Arthropathy in sarcoidosis
65.6
11.6
13
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.3
11.6
89
403
L50.9
ICD-10 Finland
Urticaria, unspecified
4.3
11.3
29
69
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.7
11.3
61
234
J01MA12
ATC
levofloxacin; systemic
1.8
11.3
194
1173
D86.3
ICD-10 Finland
Sarcoidosis of skin
20.3
11.1
16
8
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.5
10.9
70
292
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
10.8
418
3101
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
10.7
213
1340
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.3
10.7
82
371
L03.9
ICD-10 Finland
Cellulitis, unspecified
3.9
10.7
31
81
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.6
10.5
265
1774
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.2
10.3
94
457
R06.0
ICD-10 Finland
Dyspnoea
1.6
10.2
290
1998
P01BA02
ATC
hydroxychloroquine; oral
2.0
10.1
108
558
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
2.7
10.0
52
196
J01AA02
ATC
doxycycline; systemic
1.6
9.9
861
7519
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
9.6
244
1633
R03AC02
ATC
salbutamol; inhalant
1.5
9.5
630
5179
S01
ICPC
Pain/tenderness of skin
2.6
9.4
56
226
S18
ICPC
Laceration/cut
1.5
9.4
480
3745
13599
ICD-8 Finland
Sarcoidosis, Unspecified
12.5
9.4
16
13
C03DA01
ATC
spironolactone; oral
1.9
9.3
124
692
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.9
9.2
131
747
J01DA09
ATC
[U] cefadroxil
1.6
9.1
299
2123
M02.9
ICD-10 Finland
Reactive arthropathy, unspecified
3.8
9.1
27
72
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
3.8
9.1
27
72
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.3
9.1
65
286
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
9.1
9.0
18
20
XG410
NOMESCO Finland
Flow-volume spirometry
2.6
8.9
49
190
SPAT1262
SPAT
Handing over of treatment supplies
1.7
8.8
178
1121
A07EC01
ATC
sulfasalazine; oral, rectal
2.0
8.7
96
502
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
3.0
8.5
36
121
L04AB04
ATC
adalimumab; parenteral
3.1
8.4
34
111
L17
ICPC
Foot/toe symptom/complaint
1.5
8.4
313
2281
M30.0
ICD-10 Finland
Polyarteritis nodosa
17.3
8.1
12
7
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
8.0
471
3746
I50.9
ICD-10 Finland
Heart failure, unspecified
1.8
7.9
125
735
L95.8
ICD-10 Finland
Other vasculitis limited to skin
13.1
7.9
13
10
I80.8
ICD-10 Finland
Phlebitis and thrombophlebitis of other sites
3.8
7.8
23
61
SPAT1260
SPAT
Consultation of another employee
1.6
7.8
188
1238
D07AC13
ATC
mometasone; topical
1.5
7.6
304
2238
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.8
7.6
127
758
P01AB01
ATC
metronidazole; oral, rectal
1.4
7.6
456
3629
B01AB05
ATC
enoxaparin; parenteral
1.5
7.5
333
2502
L03.1
ICD-10 Finland
Cellulitis of other parts of limb
2.8
7.5
37
136
QX3HE
NOMESCO Finland
Ultrsound examination of lesion close to skin
3.7
7.5
23
63
T90
ICPC
Diabetes non-insulin dependent
1.6
7.5
224
1552
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.6
7.5
177
1161
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
2.4
7.4
49
208
N02AX02
ATC
tramadol; systemic, rectal
1.4
7.4
433
3424
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
3.3
7.4
27
83
UKC02
NOMESCO Finland
Cystoscopy
1.7
7.3
131
798
A18.4
ICD-10 Finland
Tuberculosis of skin and subcutaneous tissue
+∞
7.3
7
*
6952C
ICD-9 Finland
Erythematous conditions, Erythema nodosum[VASCULITIS NODULARIS,ERYTHEMA INDURATUM NONTUBERCUL]
+∞
7.3
7
*
D07AD01
ATC
clobetasol; topical
1.6
7.3
177
1168
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
2.6
7.2
41
162
M07.4*K50.9
ICD-10 Finland
Arthropathy in Crohn's disease [regional enteritis]
15.9
7.2
11
7
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
4.3
7.2
18
42
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.9
7.2
93
513
J02AC01
ATC
fluconazole; systemic
1.4
7.2
470
3787
L50.8
ICD-10 Finland
Other urticaria
8.8
7.1
14
16
S97
ICPC
Chronic ulcer skin
2.1
7.0
64
313
L04AD01
ATC
ciclosporin; systemic
3.5
6.9
23
67
J01FA06
ATC
roxithromycin; oral
1.4
6.9
431
3441
L01BA01
ATC
methotrexate; systemic
2.4
6.8
44
185
XW000
NOMESCO Finland
Bone marrow biopsy
2.5
6.8
43
179
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
8.3
6.8
14
17
K51
ICD-10 Finland
Ulcerative colitis
4.1
6.8
18
44
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
4.1
6.8
18
44
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.7
6.8
139
877
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.2
6.8
55
256
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.2
6.8
53
243
K61.0
ICD-10 Finland
Anal abscess
3.7
6.8
21
58
03992
ICD-8 Finland
Other bacterial diseases, Infectio Yersinia (Pasteurella) enterocolitica
40.3
6.8
8
*
R05
ICD-10 Finland
Cough
1.5
6.7
230
1636
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
2.4
6.7
43
181
M25.5
ICD-10 Finland
Pain in joint
1.4
6.7
356
2759
E000001, ,
ATC
1.5
6.7
211
1477
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.5
6.7
221
1563
L04AD02
ATC
tacrolimus; systemic
6.5
6.6
16
25
J04BA02
ATC
dapsone; oral
7.9
6.6
14
18
E66.01
ICD-10 Finland
Obesity due to excess calories
1.8
6.6
109
649
M05BA04
ATC
alendronic acid; oral
1.8
6.6
99
573
GD1AD
NOMESCO Finland
Thorax CT examination
2.1
6.5
59
287
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
2.4
6.5
41
171
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.3
6.5
47
209
M79.6
ICD-10 Finland
Pain in limb
1.4
6.5
452
3665
D86
ICD-10 Finland
Sarcoidosis
14.4
6.4
10
7
I80.3
ICD-10 Finland
Phlebitis and thrombophlebitis of lower extremities, unspecified
2.4
6.4
43
185
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
4.1
6.4
17
42
JN3AD
NOMESCO Finland
Abdominal CT examination
1.7
6.3
112
680
K50
ICD-10 Finland
Crohn disease [regional enteritis]
11.1
6.3
11
10
L04AC05
ATC
ustekinumab; parenteral
9.3
6.3
12
13
S76
ICPC
Skin infection other
2.1
6.3
57
278
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.7
6.3
129
816
D94
ICPC
Chronic enteritis/ulcerative colitis
7.1
6.2
14
20
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
1.7
6.2
118
731
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
3.6
6.2
20
57
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.5
6.1
182
1257
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.7
6.1
101
603
I50.0
ICD-10 Finland
Congestive heart failure
2.0
6.0
62
317
H15.1
ICD-10 Finland
Episcleritis
3.3
6.0
22
68

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
185
240
8.99
137.59
2.8
2.2
11.33
11.90
mg/l
0.30
171
225
660
4416
2.16
35.05
11.4
6.0
—
—
—
0
0
271
1297
2.42
32.49
1.5
1.3
565.42
526.18
titre
0.13
59
285
682
4702
2.10
32.46
10.3
5.5
0.57
0.56
e9/l
0.97
619
4103
681
4712
2.09
31.85
10.4
5.5
0.04
0.04
e9/l
0.12
617
4106
698
4886
2.09
31.48
10.8
5.8
0.18
0.18
e9/l
0.02
636
4312
689
4840
2.05
30.27
10.5
5.5
1.90
1.91
e9/l
0.11
634
4319
253
1225
2.36
29.24
3.8
2.2
148.35
124.78
ug/g
0.49
216
950
388
2265
2.07
27.96
5.1
3.9
—
—
—
0
0
89
255
3.70
26.85
1.9
1.6
0.24
0.24
g/l
0.04
84
242
634
4450
1.94
26.45
11.2
5.8
8.30
8.35
%
0.17
602
4163
90
269
3.54
25.48
1.8
1.6
1.21
1.20
g/l
0.15
85
252
64
151
4.43
25.14
1.3
1.2
263.86
247.56
u/ml
0.16
42
89
626
4425
1.91
25.04
10.8
5.6
2.65
2.76
%
0.70
594
4130
60
135
4.63
25.00
1.3
1.2
—
—
—
0
0
740
5531
1.94
24.91
13.2
8.6
4.23
4.04
e9/l
1.48
680
4845
34
45
7.75
24.30
1.2
1.1
178.41
197.08
iu/ml
0.14
34
45
111
392
3.03
23.93
1.3
1.2
—
—
—
0
0
638
4580
1.88
23.88
10.9
5.6
27.17
28.43
%
2.09
606
4295
605
4275
1.87
23.76
10.9
5.6
0.66
0.68
%
0.23
572
3977
631
4527
1.87
23.53
10.4
5.4
58.86
56.98
%
3.43
598
4240
627
4512
1.85
22.92
8.6
6.2
1.22
1.22
mmol/l
0.13
528
3822
877
7070
2.00
22.11
6.8
4.0
16.46
11.88
mm/h
11.90
830
6540
576
4070
1.83
22.02
7.4
5.5
1.22
1.22
mmol/l
0.10
533
3700
420
2717
1.86
21.16
5.0
3.8
7.40
7.40
ph
0.07
86
519
67
192
3.64
20.18
1.8
1.9
4.74
5.01
mmol/24h
0.28
61
169
88
303
3.06
19.79
1.5
1.2
—
—
—
0
0
26
32
8.29
19.69
1.3
1.0
—
—
—
0
0
546
3913
1.75
18.91
6.4
4.4
35.09
35.85
g/l
2.47
513
3656
879
7242
1.90
18.75
11.1
7.0
77.83
77.17
u/l
0.22
840
6805
815
6596
1.80
17.95
5.6
4.2
—
—
—
0
0
54
148
3.78
17.36
1.4
1.3
—
—
—
0
0
354
2286
1.79
17.23
3.1
2.4
3346.34
4993.21
umol/l
0.40
316
2001
555
4107
1.68
16.25
2.9
2.3
76.64
77.16
nmol/l
0.17
515
3691
630
4819
1.68
16.24
7.1
5.7
10.03
10.99
umol/l
2.14
605
4571
300
1883
1.80
15.87
2.8
2.4
6.61
7.33
e6/l
0.38
266
1704
331
2139
1.77
15.85
2.1
1.6
1.10
1.04
mg/l
0.14
258
1630
170
894
2.06
15.29
2.4
2.0
334.92
374.07
nmol/l
1.69
159
818
777
6349
1.69
14.94
5.5
4.4
363.14
2230.84
e6/l
—
7
89
138
679
2.17
14.75
4.0
2.7
10.73
10.22
g/l
0.61
129
619
388
2668
1.68
14.63
3.7
3.0
94.37
75.69
e6/l
0.18
308
2038
194
1086
1.95
14.59
1.7
1.5
—
—
—
0
0
89
366
2.55
14.31
1.3
1.3
0.24
1.19
u/ml
0.79
15
28
150
774
2.08
14.15
6.6
3.8
0.91
1.09
%
0.34
64
245
184
1036
1.92
13.54
2.0
1.6
—
—
—
0
0
39
102
3.92
13.41
1.2
1.2
—
—
—
0
0
442
3201
1.62
13.30
4.5
3.5
66.58
77.31
e6/l
0.23
330
2207
138
707
2.08
13.25
6.3
3.7
0.44
0.72
%
1.34
55
206
354
2432
1.66
13.12
3.6
2.9
0.26
0.45
e6/l
2.18
281
1839
549
4212
1.58
12.80
14.3
8.9
0.00
0.00
e9/l
0.19
474
3469
112
536
2.21
12.79
2.2
1.7
1.03
1.42
g/l
1.86
102
492
130
666
2.07
12.47
3.2
2.5
75.65
72.94
e9/l
0.26
93
500
33
81
4.16
12.36
1.8
1.4
—
—
—
0
0
139
733
2.02
12.32
6.6
3.9
0.11
0.14
%
0.17
53
205
163
917
1.91
11.96
4.1
2.4
1.91
1.86
%
0.20
146
811
599
4736
1.55
11.91
4.7
3.6
0.00
0.00
estimate
0.75
145
958
32
79
4.14
11.90
1.6
1.4
7.61
7.14
g/l
0.16
24
54
32
79
4.14
11.90
1.6
1.4
0.38
0.35
g/l
0.19
24
54
32
79
4.14
11.90
1.6
1.4
2.84
2.68
g/l
0.17
24
52
117
590
2.09
11.69
2.7
2.4
—
—
—
0
0
344
2406
1.61
11.62
3.4
2.9
—
—
—
0
0
334
2325
1.61
11.48
2.9
2.1
3.33
2.97
mg/l
1.47
292
1969
26
56
4.73
11.45
2.0
1.9
40.05
37.86
%
0.27
26
56
284
1900
1.66
11.44
2.0
1.8
—
—
—
0
0
131
696
2.00
11.35
6.9
4.0
0.17
0.66
%
0.44
46
167
599
4803
1.51
10.71
4.7
3.6
0.00
0.00
estimate
0.50
142
877
191
1167
1.76
10.67
3.2
2.3
19.57
22.54
%
2.64
163
1001
172
1020
1.81
10.63
1.6
1.3
—
—
—
0
0
515
4010
1.51
10.53
15.3
13.1
1.16
1.21
inr
0.61
170
1211
216
1376
1.70
10.38
3.2
2.2
11.59
13.13
umol/l
2.87
203
1274
126
683
1.95
10.29
3.2
2.9
67.18
66.88
g/l
0.17
117
624
41
133
3.16
10.25
1.8
1.7
0.78
0.80
g/l
0.05
31
101
200
1255
1.72
10.14
2.2
1.9
—
—
—
0
0
652
5357
1.50
10.12
5.5
4.5
6.74
6.58
mmol/l
0.97
610
4982
591
4765
1.49
10.03
6.1
4.9
0.00
0.00
estimate
0.50
142
894
1045
9608
1.94
9.83
22.7
12.7
24.66
21.65
mg/l
2.10
910
7530
62
260
2.46
9.61
1.3
1.2
4.38
11.45
u/ml
—
10
50
262
1786
1.60
9.59
3.3
2.7
533.46
528.93
mosm/kgh2o
0.12
220
1551
408
3076
1.51
9.47
3.4
3.0
—
—
—
0
0
61
257
2.45
9.36
1.3
1.2
3.06
2.54
u/ml
—
5
29
236
1584
1.62
9.17
1.7
1.6
—
—
—
0
0
196
1255
1.68
9.17
3.2
2.2
2.39
2.37
g/l
0.21
180
1154
344
2520
1.52
9.09
5.4
3.9
0.02
0.00
estimate
0.39
142
884
483
3806
1.46
8.83
4.2
3.3
5.67
5.87
ph
0.66
27
292
278
1956
1.56
8.79
1.9
1.4
2.69
2.29
g/l
1.30
173
1189
549
4456
1.44
8.46
3.7
2.7
112.66
98.37
ug/l
0.72
526
4116
465
3669
1.45
8.29
2.2
1.9
95.31
96.49
pmol/l
0.18
243
1859
73
355
2.13
8.04
1.8
1.9
1.59
1.53
g/l
0.20
64
311
173
1108
1.66
8.04
8.4
4.8
1.03
1.03
mmol/l
0.02
163
1023
363
2749
1.47
7.95
3.5
3.1
7.27
7.23
mmol/l
0.05
307
2329
56
245
2.35
7.95
3.2
3.9
39.88
70.74
mg/l
0.59
50
193
56
245
2.35
7.95
3.2
3.9
59.35
43.26
mg/l
0.27
50
193
47
192
2.51
7.74
4.9
3.9
61.62
57.91
%
1.32
47
192
322
2395
1.48
7.69
10.2
6.5
—
—
—
0
0
17
23
7.48
7.68
2.1
2.1
—
—
—
0
0
236
1649
1.54
7.59
1.9
1.7
1234.57
1207.38
nmol/l
0.17
193
1228
100
563
1.85
7.28
1.3
1.2
—
—
—
0
0
45
186
2.48
7.24
4.3
3.8
4.30
4.20
e9/l
0.13
45
186
121
723
1.75
7.24
1.4
1.3
—
—
—
0
0
1047
9782
1.77
7.24
21.8
14.4
3.94
3.94
mmol/l
0.26
1022
9502
248
1769
1.51
7.22
1.3
1.2
35.24
33.13
iu/ml
0.07
80
577
113
663
1.78
7.19
8.8
7.1
—
—
—
0
0
46
197
2.39
6.88
1.6
1.7
12563.27
14174.38
e6/l
0.10
37
145
1043
9759
1.72
6.84
21.5
14.3
139.58
139.63
mmol/l
0.32
1019
9497
20
53
3.82
6.82
2.1
1.9
447.73
497.43
e6/l
0.19
15
44
304
2284
1.45
6.77
1.4
1.3
1.96
1.75
u/ml
0.09
83
614
104
609
1.78
6.67
1.5
1.2
225.15
195.47
u/ml
0.13
96
557
236
1696
1.49
6.57
1.4
1.2
8.95
12.16
u/ml
0.31
87
650
315
2396
1.43
6.53
3.8
2.9
2021.00
1142.39
ng/l
0.61
264
2012
369
2894
1.40
6.42
2.8
2.4
62.93
59.98
u/l
0.17
347
2665
37
148
2.55
6.40
1.6
1.3
110.89
112.89
u/ml
—
6
28
159
1054
1.59
6.39
3.7
2.5
6.55
7.78
umol/l
0.50
135
894
58
283
2.11
6.38
2.9
3.1
0.24
0.27
g/l
0.19
32
104
128
808
1.66
6.26
2.6
2.1
0.22
0.21
g/l
0.56
116
758
326
2515
1.41
6.20
3.8
3.2
201.64
337.18
mg/l
0.33
200
1563
1075
10187
1.82
6.16
15.1
9.7
24.78
24.93
u/l
0.12
1037
9838
341
2657
1.40
6.11
4.5
3.8
7.33
8.38
mg/mmol
0.16
211
1628
202
1431
1.50
6.00
4.5
3.2
0.82
0.82
mmol/l
0.06
193
1347
416
3359
1.37
5.99
4.2
3.4
33.85
42.76
ng/l
0.30
276
2169
25
84
3.02
5.98
2.2
3.3
—
—
—
0
0
400
3212
1.38
5.95
3.3
3.3
2.36
2.36
mmol/l
0.16
351
2845
107
659
1.69
5.76
2.4
2.4
51.76
22.57
au/ml
—
5
51
134
876
1.60
5.70
6.0
3.7
—
—
—
0
0
132
860
1.60
5.70
2.3
2.2
35.35
37.56
u/l
0.11
107
722
388
3118
1.37
5.69
3.7
3.0
29.93
30.58
u/l
0.18
368
2966
49
235
2.13
5.66
1.3
1.2
348.00
60.00
titre
—
5
16
853
7743
1.39
5.58
4.7
4.2
14.67
14.66
pmol/l
0.03
782
7078
16
32
5.06
5.57
2.0
1.3
—
—
—
0
0
119
761
1.63
5.54
5.4
3.4
2.12
2.05
mmol/l
0.08
102
631
281
2149
1.41
5.54
4.5
3.6
—
—
—
0
0
201
1445
1.47
5.53
3.2
2.6
1.09
1.13
e6/l
0.07
123
799
111
699
1.65
5.49
5.0
3.5
—
—
—
0
0
84
490
1.77
5.49
4.2
3.8
7.43
7.41
ph
—
10
58
41
186
2.25
5.43
3.2
4.2
—
—
—
0
0
8
5
16.10
5.41
1.1
1.2
—
—
—
0
0
40
181
2.25
5.34
1.3
1.2
—
—
—
0
0
39
176
2.26
5.24
1.8
1.7
—
—
—
0
0
46
223
2.11
5.19
1.2
1.2
27.82
36.35
u/ml
—
5
23
125
823
1.58
5.17
4.9
3.9
—
—
—
0
0
31
127
2.48
5.15
3.0
2.5
—
—
—
0
0
293
2281
1.38
5.15
5.4
3.5
92.77
93.39
%
0.15
284
2218
118
767
1.60
5.15
5.6
3.4
5.91
5.82
kpa
0.46
111
744
16
36
4.49
5.06
3.6
2.3
33.83
262.55
ug/l
0.46
16
29
63
346
1.87
5.02
2.9
1.8
21.37
21.01
s
0.34
57
304
255
1960
1.39
4.81
1.9
1.7
419.23
37284386.55
pmol/l
2.40
213
1620
65
367
1.82
4.76
4.3
3.9
—
—
—
0
0
331
2656
1.35
4.75
4.3
3.2
—
—
—
0
0
135
924
1.52
4.71
6.9
7.3
1.09
1.24
mmol/l
0.19
117
744
464
3917
1.31
4.64
2.4
2.1
—
—
—
0
0
36
166
2.21
4.63
1.6
1.4
—
—
—
0
0
15
43
3.52
4.62
1.1
1.0
—
—
—
0
0
115
763
1.56
4.61
4.2
3.5
1.23
1.23
mmol/l
0.50
101
648
21
75
2.83
4.57
1.4
1.1
—
—
—
0
0
99
637
1.61
4.52
1.6
1.4
—
—
—
0
0
911
8455
1.37
4.48
24.1
15.3
15.41
14.77
%
2.27
893
8309
183
1347
1.43
4.42
2.9
1.9
29.96
29.42
s
0.49
177
1300
263
2063
1.36
4.34
5.1
3.9
1.02
1.02
kg/l
0.35
45
286
15
45
3.36
4.33
1.1
1.0
—
—
—
0
0
146
1034
1.47
4.32
7.9
6.1
104.64
104.34
mmol/l
0.39
146
1034
99
646
1.58
4.28
2.6
3.5
4.44
4.53
pmol/l
0.24
92
571
53
293
1.85
4.18
16.0
9.4
—
—
—
0
0
23
91
2.56
4.15
1.1
1.1
—
—
—
0
0
29
129
2.28
4.08
2.0
1.5
—
—
—
0
0
113
770
1.52
4.04
1.4
1.4
—
—
—
0
0
180
1342
1.40
4.03
3.6
2.8
5.69
3.60
e6/l
1.06
102
700
24
100
2.43
3.91
1.6
2.8
—
—
—
0
0
719
6514
1.28
3.85
4.0
3.6
—
—
—
0
0
10
19
5.30
3.83
1.3
1.2
—
—
—
0
0
22
89
2.50
3.81
1.3
1.2
—
—
—
0
0
22
89
2.50
3.81
1.3
1.1
—
—
—
0
0
30
140
2.17
3.79
1.2
1.0
—
—
—
0
0
263
2104
1.32
3.75
1.6
1.5
18.98
21.56
nmol/l
2.31
224
1792
27
122
2.24
3.69
1.1
1.2
—
—
—
0
0
10
20
5.03
3.69
1.0
1.0
—
—
—
0
0
217
1698
1.34
3.60
2.6
2.8
2.46
2.45
mmol/l
0.32
195
1497
47
264
1.81
3.56
4.4
3.3
—
—
—
0
0
174
1320
1.37
3.51
1.2
1.2
—
—
—
0
0
11
26
4.26
3.51
1.8
1.3
—
—
—
0
0
325
2702
1.28
3.45
2.4
2.1
113.23
200.46
u/l
2.84
304
2563
22
95
2.34
3.35
1.1
1.3
—
—
—
0
0
98
678
1.49
3.29
2.8
2.8
208.75
179.42
ng/l
0.24
83
617
956
9055
1.33
3.23
5.8
5.0
1.89
2.00
mu/l
0.39
892
8354
104
732
1.46
3.21
4.8
3.4
85.16
80.22
ng/l
0.24
90
634
143
1067
1.39
3.20
1.7
1.4
—
—
—
0
0
350
2961
1.26
3.19
3.9
2.1
—
—
—
0
0
92
637
1.48
3.09
5.2
2.9
4.31
4.58
kpa
0.62
86
614
93
647
1.48
3.05
3.4
2.8
3.98
6.47
e9/l
1.53
73
538
105
749
1.44
3.03
1.3
1.2
197.29
154.75
iu/ml
0.43
43
296
15
57
2.65
2.97
1.5
1.3
3787.14
174418.07
e6/l
—
7
30
27
135
2.02
2.92
1.3
1.5
—
—
—
0
0
30
156
1.95
2.92
1.4
1.2
2.67
5.18
u/ml
0.77
18
60
1047
10090
1.41
2.88
18.1
12.0
—
—
—
0
0
22
102
2.18
2.88
2.2
2.7
—
—
—
0
0
81
555
1.49
2.88
4.1
5.7
—
—
—
0
0
23
109
2.13
2.86
1.9
1.7
65.00
60.64
%
0.24
17
73
270
2242
1.27
2.84
3.6
2.1
—
—
—
0
0
8
18
4.47
2.79
6.3
3.0
—
—
—
0
0
10
28
3.59
2.78
1.2
1.3
—
—
—
0
0
30
159
1.91
2.77
1.8
1.7
—
—
—
0
0
16
66
2.44
2.71
1.4
1.1
—
—
—
0
0
19
85
2.26
2.71
2.1
2.8
1.26
1.38
g/24h
—
6
46
305
2584
1.25
2.69
4.0
3.6
—
—
—
0
0
137
1046
1.35
2.68
1.6
1.4
—
—
—
0
0
16
67
2.41
2.64
1.5
1.3
2232.50
1804.80
e6/l
—
10
46
691
6368
1.21
2.62
3.4
2.9
43.37
44.41
u/l
0.18
647
5960
105
771
1.40
2.61
6.5
7.9
117.08
120.51
g/l
1.04
105
751
8
20
4.02
2.57
1.0
1.2
—
—
—
0
0
206
1675
1.28
2.57
4.2
3.5
581.36
323.21
ng/l
0.35
152
1209
1101
10739
1.56
2.56
30.7
18.9
264.55
257.09
e9/l
2.85
1075
10469
12
44
2.75
2.55
3.2
2.6
41875.00
36029.66
ug/l
0.83
12
44
6
11
5.48
2.54
1.0
2.9
0.50
0.64
u/field
—
6
11
17
75
2.29
2.51
1.4
1.2
—
—
—
0
0
1101
10744
1.55
2.49
30.6
18.9
90.58
90.79
fl
0.70
1083
10597
106
787
1.38
2.48
1.2
1.2
—
—
—
0
0
27
144
1.90
2.48
1.2
1.1
—
—
—
0
0
7
16
4.39
2.47
1.0
1.1
—
—
—
0
0
1101
10746
1.54
2.46
30.7
18.9
6.86
6.64
e9/l
2.66
1073
10451
1101
10746
1.54
2.46
30.7
18.9
4.43
4.46
e12/l
0.96
1072
10457
1101
10746
1.54
2.46
30.5
18.8
29.96
30.19
pg
3.83
1083
10598
1100
10735
1.54
2.45
30.7
18.9
39.63
39.79
%
0.46
1035
10087
16
70
2.30
2.42
1.6
2.0
2.55
2.21
u/field
0.08
11
34
1101
10751
1.53
2.40
31.0
19.0
131.70
133.87
g/l
5.46
1084
10601
21
104
2.04
2.37
1.9
1.6
—
—
—
0
0
30
171
1.77
2.26
3.1
3.3
—
—
—
0
0
76
544
1.43
2.21
1.4
1.3
24.04
28.75
iu/l
0.68
65
467
11
41
2.70
2.21
1.4
1.5
—
—
—
0
0
7
19
3.70
2.15
2.1
1.6
—
—
—
0
0
14
62
2.27
2.08
1.4
1.4
—
—
—
0
0
9
31
2.92
2.07
1.8
1.7
—
—
—
0
0
9
31
2.92
2.07
1.3
1.3
—
—
—
0
0
49
328
1.52
2.01
5.2
4.6
—
—
—
0
0
11
44
2.51
2.01
1.1
1.6
—
—
—
0
0
53
362
1.49
1.99
1.6
1.6
—
—
—
0
0
13
57
2.30
1.98
1.6
1.3
—
—
—
0
0
91
687
1.35
1.96
3.4
2.3
5.01
6.40
ug/l
0.58
71
608
9
33
2.74
1.93
1.9
2.9
—
—
—
0
0
17
85
2.01
1.91
27.9
8.7
6.74
6.78
mmol/l
0.02
12
64
900
8611
1.21
1.89
6.3
5.4
40.36
39.33
mmol/mol
2.37
843
8006
6
17
3.54
1.84
1.3
1.4
—
—
—
0
0
28
169
1.67
1.78
1.7
1.5
50.39
42.86
nmol/l
0.29
28
163
26
154
1.70
1.77
1.0
1.0
3.28
1.92
u/ml
—
10
77
42
282
1.51
1.74
2.2
2.5
—
—
—
0
0
59
424
1.41
1.73
10.5
9.8
—
—
—
0
0
5
13
3.86
1.71
1.0
1.1
—
—
—
0
0
61
442
1.40
1.71
2.9
2.3
—
—
—
0
0
58
418
1.41
1.68
1.9
1.8
—
—
—
0
0
25
149
1.69
1.67
1.8
1.4
—
—
—
0
0
6
19
3.17
1.66
1.3
1.2
—
—
—
0
0
6
19
3.17
1.66
2.3
1.6
—
—
—
0
0
490
4497
1.16
1.65
3.6
2.4
—
—
—
0
0
39
261
1.51
1.65
1.5
1.3
13.13
10.49
u/l
0.56
31
212
20
113
1.78
1.61
4.9
5.3
12.63
11.76
mg/l
0.33
20
103
17
92
1.86
1.56
1.2
1.8
—
—
—
0
0
18
100
1.81
1.53
1.6
1.9
33.50
32.31
pg
0.44
18
100
69
523
1.34
1.50
7.0
8.1
24.41
24.55
mmol/l
0.11
69
501
28
179
1.58
1.46
2.5
2.1
117.11
129.58
g/l
0.80
17
137
22
132
1.68
1.46
1.5
1.3
0.55
0.61
nmol/l
0.45
22
126
37
253
1.48
1.44
1.3
1.2
—
—
—
0
0
21
125
1.69
1.44
1.6
1.3
—
—
—
0
0
13
68
1.92
1.33
1.3
1.4
—
—
—
0
0
12
61
1.98
1.33
1.1
1.1
1.00
1.05
ratio
—
5
28
26
169
1.55
1.29
3.5
2.4
—
—
—
0
0
19
114
1.68
1.28
1.8
2.1
—
—
—
0
0
25
162
1.56
1.26
1.5
1.7
—
—
—
0
0
43
313
1.39
1.24
1.2
1.2
—
—
—
0
0
13
71
1.84
1.19
1.0
1.1
—
—
—
0
0
14
79
1.78
1.17
2.9
2.8
—
—
—
0
0
10
50
2.01
1.16
1.2
1.2
—
—
—
0
0
16
260
0.61
1.16
1.3
1.4
—
—
—
0
0
16
259
0.61
1.15
1.3
1.4
—
—
—
0
0
52
397
1.32
1.13
1.1
1.1
—
—
—
0
0
19
119
1.61
1.12
4.5
3.1
—
—
—
0
0
17
268
0.63
1.10
1.3
1.4
—
—
—
0
0
24
160
1.51
1.10
3.8
3.2
0.75
0.87
nmol/l
0.75
19
127
37
269
1.39
1.09
1.3
1.2
—
—
—
0
0
37
269
1.39
1.09
1.4
1.4
248.53
286.65
ug/g
0.56
19
157
23
152
1.52
1.09
1.3
1.2
—
—
—
0
0
27
186
1.46
1.06
1.1
1.6
—
—
—
0
0
10
52
1.93
1.06
1.2
1.2
—
—
—
0
0
28
195
1.45
1.05
3.4
3.6
2.98
2.66
mmol/l
0.19
19
133
12
67
1.80
1.05
5.1
3.5
—
—
—
0
0
7
34
2.07
1.03
1.0
1.0
—
—
—
0
0
26
180
1.45
1.01
4.7
2.8
—
—
—
0
0
326
3529
0.89
0.97
2.8
2.7
—
—
—
0
0
105
892
1.19
0.95
3.5
3.9
17.61
21.38
ug/l
0.08
78
727
11
62
1.78
0.94
4.3
2.0
—
—
—
0
0
13
209
0.62
0.94
3.6
3.7
54.49
33.75
u/ml
0.30
13
204
16
101
1.59
0.94
4.4
3.1
—
—
—
0
0
24
167
1.45
0.92
2.5
2.2
16.08
16.01
%
0.03
13
72
45
349
1.30
0.91
1.3
1.3
212.84
228.83
miu/ml
0.09
18
164
18
118
1.53
0.91
1.1
1.1
1.14
6.96
u/ml
1.98
11
41
22
151
1.47
0.91
1.1
1.1
0.25
0.71
u/ml
1.35
13
56
22
151
1.47
0.91
1.0
1.1
0.29
1.92
u/ml
3.05
13
73
37
280
1.33
0.89
1.6
1.9
7.28
5.21
iu/l
0.30
11
101
8
42
1.91
0.88
1.0
1.4
136.50
147.60
nmol/l
—
8
42
944
9220
1.13
0.88
4.8
4.3
5.96
5.85
mmol/l
1.52
872
8417
8
43
1.87
0.87
1.0
1.2
—
—
—
0
0
6
30
2.01
0.87
1.3
1.7
97.40
79.20
nmol/24h
—
6
30
18
120
1.51
0.85
1.3
1.3
—
—
nmol/l
—
0
0
13
80
1.63
0.84
2.2
2.3
—
—
—
0
0
25
179
1.41
0.84
1.2
1.1
1.42
3.18
u/ml
0.74
13
88
271
2491
1.11
0.83
1.8
1.6
1.38
1.35
mmol/l
0.24
222
2115
52
642
0.80
0.82
1.4
1.4
—
—
—
0
0
6
32
1.88
0.82
1.0
1.3
76.28
164.73
pmol/l
—
6
32
17
114
1.50
0.79
1.6
1.6
—
—
—
0
0
22
156
1.42
0.79
1.1
1.1
4.64
3.90
u/ml
0.15
12
71
133
1177
1.15
0.76
1.3
1.2
—
—
—
0
0
11
67
1.65
0.75
1.3
1.6
12.33
11.67
umol/l
0.10
11
62
13
83
1.57
0.75
1.0
1.1
—
—
—
0
0
20
141
1.43
0.75
6.7
5.9
310.95
378.81
umol/l
1.18
20
124
5
24
2.09
0.74
6.0
3.5
58.10
50.96
%
—
5
24
5
24
2.09
0.74
1.0
1.2
—
—
—
0
0
11
69
1.60
0.68
1.4
1.6
—
—
—
0
0
7
121
0.58
0.67
1.1
1.1
—
—
—
0
0
14
94
1.50
0.67
1.0
1.1
—
—
—
0
0
7
43
1.63
0.67
1.6
1.4
131.00
163.76
mmol/24h
—
7
43
7
43
1.63
0.67
1.1
1.3
—
—
—
0
0
28
216
1.30
0.63
1.2
1.3
3.77
3.80
mmol/l
0.04
28
198
153
1390
1.12
0.61
4.7
4.7
2.90
2.32
ug/l
0.42
135
1244
37
299
1.25
0.60
1.3
1.5
—
—
—
0
0
0
22
0.00
0.59
0.0
1.1
—
—
—
0
0
53
446
1.20
0.59
2.3
2.1
10160.97
3737.89
u/l
0.68
20
186
6
35
1.72
0.57
3.7
2.1
—
—
—
0
0
49
415
1.19
0.52
2.8
2.0
12.89
11.93
nmol/l
0.23
43
376
21
161
1.31
0.52
1.3
1.7
—
—
—
0
0
6
40
1.50
0.51
1.3
3.6
—
—
—
0
0
123
1117
1.11
0.51
1.6
1.8
—
—
—
0
0
10
67
1.50
0.49
1.6
1.3
86.40
74.88
umol/l
—
10
67
87
973
0.89
0.49
1.4
1.3
—
—
—
0
0
26
209
1.25
0.46
2.0
2.3
47.60
120.34
ug/min
1.00
14
129
53
610
0.86
0.46
1.5
1.7
—
—
—
0
0
37
312
1.19
0.43
2.5
3.0
104.40
738.84
u/ml
0.79
29
269
12
87
1.38
0.42
1.1
1.6
—
—
—
0
0
5
32
1.56
0.42
1.6
1.9
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
20
249
0.80
0.40
1.8
2.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
26.70
—
0
13
21
169
1.25
0.39
2.5
3.2
33.43
34.64
umol/l
0.10
21
154
17
133
1.28
0.38
1.1
1.0
0.62
5.11
u/ml
3.10
11
61
11
80
1.38
0.38
1.4
1.6
0.90
0.98
g/l
0.51
11
80
21
170
1.24
0.37
1.0
1.1
—
—
—
0
0
21
170
1.24
0.37
1.0
1.1
—
—
—
0
0
281
2686
1.06
0.36
1.5
1.5
—
—
—
0
0
85
927
0.91
0.34
2.0
1.4
—
—
—
0
0
24
286
0.84
0.34
1.4
1.3
—
—
—
0
0
6
47
1.28
0.32
2.0
3.4
—
—
—
0
0
71
647
1.10
0.31
2.1
3.0
54.78
59.37
u/ml
0.06
66
624
39
345
1.14
0.29
4.8
6.7
1.59
1.60
%
0.03
39
325
43
384
1.12
0.28
1.3
1.5
—
—
—
0
0
43
385
1.12
0.27
1.3
1.5
—
—
—
0
0
18
151
1.20
0.25
1.4
1.4
46.92
62.82
mmol/l
1.51
12
126
40
359
1.12
0.25
1.3
1.5
—
—
—
0
0
10
78
1.28
0.24
1.4
1.3
1.93
1.51
nmol/l
—
10
69
118
1116
1.06
0.24
1.9
1.6
—
—
—
0
0
5
38
1.32
0.23
1.0
1.3
—
—
—
0
0
5
39
1.28
0.23
1.0
1.1
2167.40
1819.46
miu/ml
—
5
39
7
95
0.74
0.22
1.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
7.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
208.80
—
0
5
31
277
1.12
0.21
4.4
8.2
1.14
1.30
mmol/l
0.96
31
244
38
344
1.11
0.21
4.7
6.7
0.87
0.93
%
0.52
38
324
0
12
0.00
0.21
0.0
3.0
—
—
—
0
0
0
12
0.00
0.21
0.0
6.0
—
—
—
0
0
42
459
0.91
0.20
4.1
3.3
—
—
—
0
0
13
108
1.21
0.20
1.1
1.0
0.00
0.35
u/ml
—
5
29
6
49
1.23
0.20
1.2
1.2
31.02
35.24
nmol/l
—
6
41
932
9391
0.96
0.20
4.4
4.2
1.47
1.52
mmol/l
2.98
861
8691
899
9062
0.96
0.19
4.0
3.8
1.32
1.27
mmol/l
1.41
824
8320
965
9587
1.04
0.18
4.9
4.7
2.77
2.81
mmol/l
0.96
897
8881
7
63
1.11
0.17
1.4
1.4
—
—
—
0
0
8
69
1.16
0.16
1.3
1.4
1.36
1.58
g/l
—
8
69
8
72
1.11
0.16
1.0
1.1
—
—
—
0
0
21
187
1.13
0.16
1.2
1.2
—
—
—
0
0
41
381
1.08
0.15
1.3
1.5
—
—
—
0
0
19
169
1.13
0.14
1.4
1.4
0.23
0.35
nmol/l
1.10
12
143
833
8267
1.03
0.14
26.9
16.5
330.10
331.84
g/l
5.90
824
8204
41
382
1.08
0.14
1.3
1.5
—
—
—
0
0
69
659
1.05
0.12
1.2
1.2
—
—
—
0
0
65
622
1.05
0.11
3.1
2.6
—
—
—
0
0
28
260
1.08
0.11
1.5
1.8
—
—
—
0
0
18
198
0.91
0.10
5.5
9.6
11.06
11.28
mmol/l
0.17
18
180
18
198
0.91
0.10
5.5
9.6
104.61
105.31
mmol/l
0.28
18
180
5
45
1.11
0.10
1.0
1.2
—
—
—
0
0
5
47
1.06
0.09
2.2
2.2
11.20
9.55
mmol/l
—
5
47
78
807
0.96
0.09
2.9
2.9
0.95
0.70
ug/l
1.00
48
510
12
107
1.12
0.08
2.2
2.5
—
—
—
0
0
25
234
1.07
0.08
1.1
1.1
—
—
—
0
0
7
66
1.06
0.08
7.7
7.2
—
—
—
0
0
7
68
1.03
0.08
16.4
11.4
0.60
0.62
mmol/l
—
7
61
8
75
1.07
0.07
1.4
1.2
—
—
—
0
0
24
228
1.05
0.05
5.0
4.3
—
—
—
0
0
40
409
0.98
0.02
1.1
1.1
—
—
—
0
0
943
9425
1.00
0.00
4.5
4.2
4.69
4.76
mmol/l
1.54
873
8776
12
115
1.04
0.00
1.6
1.9
90.11
90.42
%
0.09
12
115
0
7
0.00
-0.00
0.0
1.1
—
17.11
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
-0.00
1.4
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
169.80
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
53
0.94
-0.00
1.0
1.2
—
8.13
—
0
8
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
6
62
0.97
-0.00
1.7
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.7
—
—
—
0
0
7
76
0.92
-0.00
3.0
1.8
9.63
6.62
mmol/l
—
7
51
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
53
0.94
-0.00
1.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint L12_ERYTHEMANODOSUM and mortality.

Females

Parameter HR [95% CI] p-value
L12_ERYTHEMANODOSUM 1.225 [1.06, 1.41] 0.005
Birth year 0.99 [0.98, 1.0] 0.027

During the follow-up period (1.1.1998 — 31.12.2019), 380 out of 3301 females with L12_ERYTHEMANODOSUM died.

Males

Parameter HR [95% CI] p-value
L12_ERYTHEMANODOSUM 1.581 [1.26, 1.98] < 0.001
Birth year 0.984 [0.97, 1.0] 0.01

During the follow-up period (1.1.1998 — 31.12.2019), 148 out of 1122 males with L12_ERYTHEMANODOSUM died.

Mortality risk

Mortality risk for people of age

years, who have L12_ERYTHEMANODOSUM.

N-year risk Females Males
1 0.106% 0.252%
5 0.531% 1.652%
10 1.452% 4.087%
15 2.738% 7.634%
20 5.092% 12.892%

Relationships between endpoints

Index endpoint: L12_ERYTHEMANODOSUM – Erythema nodosum

GWS hits: 4

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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