Calculus of lower urinary tract

N14_CALCULOWER

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 N21
  • Hospital discharge: ICD-9 594
  • Hospital discharge: ICD-8 594
  • Cause of death: ICD-10 N21
  • Cause of death: ICD-9 594
  • Cause of death: ICD-8 594

2 out of 7 registries used, show all original rules.

1965

4. Check minimum number of events

None

1965

5. Include endpoints

None

1965

6. Filter based on genotype QC (FinnGen only)

1965

Control definitions (FinnGen only)

Control exclude
N14_UROLITHIASIS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N20-N23
Name in latin
Urolithiasis viarum urinariarum inferiorum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 15015 2873 11922
Only index persons 12181 2461 9720
Unadjusted period prevalence (%)
Whole population 0.28 0.08 0.33
Only index persons 0.31 0.09 0.37
Median age at first event (years)
Whole population 65.15 55.17 67.47
Only index persons 63.53 52.20 66.39

-FinnGen-

Key figures

All Female Male
Number of individuals 1965 355 1610
Unadjusted period prevalence (%) 0.60 0.12 0.71
Median age at first event (years) 64.60 50.36 67.74

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1781
Matched controls
17810
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
KCE02
NOMESCO Finland
Transluminal endoscopic extraction of calculus from bladder
1661.4
323.0
706
7
N20.0
ICD-10 Finland
Calculus of kidney
839.3
323.0
341
5
N21.1
ICD-10 Finland
Calculus in urethra
+∞
323.0
308
*
N21.0
ICD-10 Finland
Calculus in bladder
4503599627370496.0
323.0
1200
*
N20.1
ICD-10 Finland
Calculus of ureter
3085.6
323.0
584
*
UKC02
NOMESCO Finland
Cystoscopy
9.2
323.0
1072
2513
N20.9
ICD-10 Finland
Urinary calculus, unspecified
276.1
319.4
318
14
KH1AD
NOMESCO Finland
CT of urinary organs
29.7
240.9
330
135
KBE12
NOMESCO Finland
Transluminal endoscopic extraction of calculus of ureter
2022.2
182.4
174
*
KAT00
NOMESCO Finland
Extracorporeal shock wave lithotripsy of pelvis of kidney
+∞
153.4
145
*
KH1AA
NOMESCO Finland
Urinary tract X-ray examination without contrast
76.4
153.0
173
25
KED22
NOMESCO Finland
Transurethral resection of prostate
5.8
150.2
494
1114
R31
ICD-10 Finland
Unspecified haematuria
5.1
149.2
559
1463
N21.9
ICD-10 Finland
Calculus of lower urinary tract, unspecified
+∞
135.1
128
*
KBV02
NOMESCO Finland
Cystoscopic insertion of stent into ureter
21.0
121.7
184
97
J01EA01
ATC
trimethoprim; systemic
4.0
120.9
606
2042
J01MA02
ATC
ciprofloxacin; systemic
3.2
114.1
1027
5370
XKD00
NOMESCO Finland
Uroflowmetry
3.4
113.5
747
3109
R33
ICD-10 Finland
Retention of urine
4.2
98.7
436
1275
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
3.2
88.1
580
2320
59203
ICD-8 Finland
Calculus of kidney and ureter, Calculus ureteris
+∞
84.0
80
*
5921A
ICD-9 Finland
Calculus of kidney and ureter, Calculus of ureter
+∞
84.0
80
*
KBV12
NOMESCO Finland
Transluminal endoscopic removal of stent from ureter
25.7
83.6
118
49
UKB02
NOMESCO Finland
Retrograde ureteroscopy
33.4
83.6
110
35
N40
ICD-10 Finland
Hyperplasia of prostate
2.7
81.5
892
4876
N30.0
ICD-10 Finland
Acute cystitis
4.3
79.5
329
887
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.7
77.0
389
1251
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
4.9
76.0
274
641
KAE12
NOMESCO Finland
Retrograde ureteronephroscopic lithotripsy in pelvis of kidney
+∞
75.6
72
*
KCE00
NOMESCO Finland
Cystolithotomy
726.5
71.6
70
*
G04CA02
ATC
tamsulosin; oral
2.5
71.0
892
5126
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.4
68.5
394
1389
KBT00
NOMESCO Finland
Extracorporeal shock wave lithotripsy of ureter
+∞
68.2
65
*
N20.2
ICD-10 Finland
Calculus of kidney with calculus of ureter
+∞
60.8
58
*
5941A
ICD-9 Finland
Calculus of lower urinary tract, Other calculus in bladder
+∞
57.6
55
*
59400
ICD-8 Finland
Calculus of other parts of urinary system, Urethrae
+∞
56.6
54
*
N21.8
ICD-10 Finland
Other lower urinary tract calculus
+∞
49.2
47
*
WX320
NOMESCO Finland
Spinalanesthesy
2.4
48.7
511
2542
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.2
43.2
620
3542
J01MA12
ATC
levofloxacin; systemic
2.3
42.0
468
2373
J01CA08
ATC
pivmecillinam; oral
2.4
40.7
422
2060
KBV10
NOMESCO Finland
Removal of stent from ureter
23.9
40.7
58
25
5920A
ICD-9 Finland
Calculus of kidney and ureter, Calculus of kidney
+∞
39.7
38
*
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
6.2
36.2
100
168
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
34.9
533
3067
TKC10
NOMESCO Finland
Percutaneous puncture of bladder
6.6
34.0
90
143
59401
ICD-8 Finland
Calculus of other parts of urinary system, Vesicae urinariae
+∞
33.4
32
*
N30.9
ICD-10 Finland
Cystitis, unspecified
4.0
32.6
138
368
TKC20
NOMESCO Finland
Catheterisation of bladder
2.8
32.4
230
897
KDV12
NOMESCO Finland
Urethroscopic internal urethrotomy
7.0
31.7
80
119
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.4
31.1
308
1445
KA1AE
NOMESCO Finland
Kidney ultrasound examination
5.0
31.0
103
216
KE1BE
NOMESCO Finland
Rectal ultrasound examinaiton of prostata
2.3
30.6
308
1459
7327
FHL
Lithotripsy
307.4
29.9
30
*
J01MA06
ATC
norfloxacin; oral
2.5
29.8
253
1097
59408
ICD-8 Finland
Calculus of other parts of urinary system, Aliae definitae
+∞
29.2
28
*
UKA02
NOMESCO Finland
Retrograde ureteronephroscopy
22.7
27.9
40
18
KDE12
NOMESCO Finland
Urethroscopic extraction of calculus of urethra
+∞
27.1
26
*
KH1LA
NOMESCO Finland
Kinetic X-ray examination of urinary tract with pictures
142.1
26.7
28
*
N02BE01
ATC
paracetamol; systemic, rectal
1.9
26.6
1444
12329
TKC22
NOMESCO Finland
Catheterisation instruction
4.5
26.5
96
221
SPAT1167
SPAT
Insertion of urinary catheter
3.5
26.5
128
382
G04CA01
ATC
alfuzosin; oral
2.0
25.3
389
2199
KH1BD
NOMESCO Finland
Extensive urinary tract CT examination
8.1
24.8
56
71
KBV00
NOMESCO Finland
Insertion of stent into ureter
14.4
24.4
41
29
KDV10
NOMESCO Finland
Internal urethrotomy
5.1
24.4
79
162
KED33
NOMESCO Finland
Transurethral incision of prostate
4.9
23.8
79
166
G04BD08
ATC
solifenacin; oral
2.8
23.4
164
630
1530
FHL
Urethrocystoscopy
4.9
23.2
77
162
G04BD12
ATC
mirabegron; oral
2.3
22.5
225
1052
XJH00
NOMESCO Finland
Transanal ultrasonography
2.2
20.5
228
1119
KED52
NOMESCO Finland
Visual laser resection of prostate
4.4
20.4
75
176
U07
ICPC
Urine symptom/complaint other
2.8
20.1
134
502
N35.9
ICD-10 Finland
Urethral stricture, unspecified
4.6
20.0
70
157
KED76
NOMESCO Finland
TUVP
6.4
19.8
52
83
N23
ICD-10 Finland
Unspecified renal colic
106.2
19.6
21
*
XKD06
NOMESCO Finland
Physiologic investigation of micturition
3.5
19.3
93
278
KA3EB
NOMESCO Finland
Antegrade pyelography
10.5
19.2
37
36
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.7
19.2
434
2769
G04CB01
ATC
finasteride; oral (testosterone-5-alpha reductase inhibitors)
1.8
19.1
385
2368
KH1BT
NOMESCO Finland
Urinary tract cathetrisation with X-ray guidance
6.4
19.0
50
80
J01MA01
ATC
ofloxacin; systemic
2.2
19.0
206
998
N13.2
ICD-10 Finland
Hydronephrosis with renal and ureteral calculous obstruction
33.3
18.0
23
7
C61
ICD-10 Finland
Malignant neoplasm of prostate
1.8
17.9
334
1995
KBV15
NOMESCO Finland
Cystoscopic change of ureteral stent
13.1
17.9
31
24
SPAT1263
SPAT
Sampling
1.6
17.9
678
4966
UKC05
NOMESCO Finland
Cystoscopy and bladder biopsy
5.5
17.9
53
99
KCF02
NOMESCO Finland
Transluminal endoscopic removal of foreign body from bladder
27.0
17.8
24
9
U06
ICPC
Haematuria
3.5
17.8
84
247
G04AC01
ATC
NA
5.1
17.7
56
113
7179
FHL
Other measure in this category
181.7
17.5
18
*
U95
ICPC
Urinary calculus
42.4
17.3
21
5
J01DB01
ATC
cefalexin; oral
1.6
16.8
1317
11406
N20
ICD-10 Finland
Calculus of kidney and ureter
171.5
16.5
17
*
Z43.5
ICD-10 Finland
Attention to cystostomy
9.1
16.4
34
38
U05
ICPC
Urination problems other
2.7
16.4
113
432
KCD02
NOMESCO Finland
Transurethral resection of bladder
3.0
16.2
94
322
N32.0
ICD-10 Finland
Bladder-neck obstruction
5.2
15.8
49
97
SPAT1262
SPAT
Handing over of treatment supplies
1.7
15.8
362
2299
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
1.8
15.4
314
1924
U29
ICPC
Urinary symptom/complaint other
3.5
15.2
72
214
J01XE01
ATC
nitrofurantoin; oral
6.6
14.9
38
59
N99.1
ICD-10 Finland
Postprocedural urethral stricture
6.7
14.8
37
56
KAE01
NOMESCO Finland
Nephroscopic nephrolithotomy
+∞
14.6
14
*
N31.2
ICD-10 Finland
Flaccid neuropathic bladder, not elsewhere classified
7.4
14.5
34
47
E83.58
ICD-10 Finland
Idiopathic hypercalciuria
151.2
14.5
15
*
R30.0
ICD-10 Finland
Dysuria
3.4
14.4
71
217
TKD00
NOMESCO Finland
Dilatation of urethra
7.0
14.4
35
51
U08
ICPC
Urinary retention
3.7
14.3
63
176
BBA30
NOMESCO Finland
Excision of lesion of parathyroid gland
7.2
14.3
34
48
UKD02
NOMESCO Finland
Urethroscopy
8.3
14.3
31
38
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
13.9
453
3154
N31.0
ICD-10 Finland
Uninhibited neuropathic bladder, not elsewhere classified
15.9
13.9
22
14
XKC03
NOMESCO Finland
Water cystometry
3.4
13.9
66
197
JN3AD
NOMESCO Finland
Abdominal CT examination
2.2
13.7
147
707
KBE22
NOMESCO Finland
Transluminal endoscopic dislodgement of impacted calculus from ureter
+∞
13.6
13
*
7171
FHL
Transurethral removal of ureteral stone
+∞
13.6
13
*
G95.8
ICD-10 Finland
Other specified diseases of spinal cord
12.2
13.1
23
19
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.2
12.9
141
682
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
4.9
12.8
41
85
N30
ICD-10 Finland
Cystitis
2.6
12.7
91
357
N30.2
ICD-10 Finland
Other chronic cystitis
11.1
12.5
23
21
J01XX05
ATC
methenamine; oral
7.4
12.5
29
40
N31.9
ICD-10 Finland
Neuromuscular dysfunction of bladder, unspecified
6.1
12.4
33
55
D41.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bladder
3.1
12.2
67
223
R35
ICD-10 Finland
Polyuria
2.1
12.1
147
747
KCW02
NOMESCO Finland
Lavation of bladder for coagulated blood
4.0
12.1
47
119
WX402
NOMESCO Finland
General anaesthesia
1.7
11.8
239
1456
C67.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bladder
2.9
11.8
73
263
G04CA52
ATC
tamsulosin and dutasteride; systemic
1.7
11.6
278
1778
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.8
11.6
196
1127
59201
ICD-8 Finland
Calculus of kidney and ureter, Calculus renis
+∞
11.5
11
*
KA1FN
NOMESCO Finland
Isotope renography
6.6
11.3
28
43
M01AB05
ATC
diclofenac; systemic, rectal
1.4
11.1
988
8362
N02AX02
ATC
tramadol; systemic, rectal
1.4
11.1
686
5431
N28.8
ICD-10 Finland
Other specified disorders of kidney and ureter
14.0
11.0
18
13
U02
ICPC
Urinary frequency/urgency
1.9
10.7
160
880
WX002
NOMESCO Finland
Sedation and analgesia
1.6
10.7
317
2141
N39.9
ICD-10 Finland
Disorder of urinary system, unspecified
4.4
10.6
37
85
204
Kela drug reimbursment
Leukemia lymphatica
4.0
10.5
41
105
KCW96
NOMESCO Finland
Other operations on bladder
5.4
10.4
30
56
N21
ICD-10 Finland
Calculus of lower urinary tract
+∞
10.4
10
*
5942A
ICD-9 Finland
Calculus of lower urinary tract, Calculus in urethra
+∞
10.4
10
*
KH1FT
NOMESCO Finland
Exchange of urinary catheter with radiological guidance
6.8
10.4
25
37
U01
ICPC
Dysuria/painful urination
2.4
10.4
87
375
G04CB02
ATC
dutasteride; oral
1.7
10.1
199
1196
N45.9
ICD-10 Finland
Orchitis, epididymitis and epididymo-orchitis without abscess
2.8
10.0
62
223
G82.0
ICD-10 Finland
Flaccid paraplegia
40.3
10.0
12
*
SPAT1053
SPAT
Memory test
1.6
9.9
303
2060
U13
ICPC
Bladder symptom/complaint other
3.0
9.9
57
197
KH1CD
NOMESCO Finland
Very extensive urinary tract ultrasound examination
4.0
9.8
38
97
N30.1
ICD-10 Finland
Interstitial cystitis (chronic)
6.6
9.7
24
37
C67.9
ICD-10 Finland
Malignant neoplasm: Bladder, unspecified
2.8
9.6
60
217
M03BX01
ATC
baclofen; systemic
3.7
9.6
41
114
R39.1
ICD-10 Finland
Other difficulties with micturition
2.5
9.4
74
308
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.6
9.4
276
1855
B02AA02
ATC
tranexamic acid; systemic
1.8
9.3
157
900
KDE20
NOMESCO Finland
Removal of foreign body from urethra
4.4
9.2
32
74
UJF32
NOMESCO Finland
Coloscopy
1.5
9.2
422
3135
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
2.4
9.1
76
328
R03DA05
ATC
aminophylline; systemic, rectal
6.3
9.1
23
37
KCD32
NOMESCO Finland
Cystoscopic destruction of tumour of bladder
3.9
9.0
35
90
G04BD07
ATC
tolterodine; oral
2.2
8.9
87
402
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
8.6
231
1519
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.6
8.5
208
1333
B01AB05
ATC
enoxaparin; parenteral
1.4
8.5
471
3614
1520
FHL
Ureteropyeloscopy
90.5
8.4
9
*
N03AX12
ATC
gabapentin; oral
1.6
8.4
220
1436
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.4
8.4
471
3625
G82.2
ICD-10 Finland
Paraplegia, unspecified
7.9
8.4
18
23
KBE00
NOMESCO Finland
Ureterolithotomy
+∞
8.3
8
*
308
Kela drug reimbursment
Alprostadil, sildenafil and combination product containing aviptadil and phentolamine
2.5
8.2
60
241
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
1.9
8.2
115
620
T19.1
ICD-10 Finland
Foreign body in bladder
14.5
8.2
13
9
U71
ICPC
Cystitis/urinary infection other
2.5
8.2
63
260
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.6
8.1
198
1269
N12
ICD-10 Finland
Tubulo-interstitial nephritis, not specified as acute or chronic
3.0
8.1
44
149
KC1AT
NOMESCO Finland
Puncture of urinary bladder with ultrasound guidance
17.2
8.1
12
7
XKD03
NOMESCO Finland
Urethral pressure profilometry
3.3
8.1
38
116
ZXA00
NOMESCO Finland
Right side
1.4
8.0
422
3202
G04BD04
ATC
oxybutynin; oral, transdermal
2.1
8.0
84
404
SPAT1301
SPAT
No procedures
1.4
8.0
485
3776
N41.0
ICD-10 Finland
Acute prostatitis
2.6
7.9
55
216
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
2.6
7.9
55
217
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.6
7.8
201
1307
G04BD11
ATC
fesoterodine; oral
2.5
7.8
57
228
6000A
ICD-9 Finland
Hyperplasia of prostate[HYPERPLASIA PROSTATAE]
2.5
7.7
57
231
N42.0
ICD-10 Finland
Calculus of prostate
45.2
7.7
9
*
ZXA05
NOMESCO Finland
Left side
1.4
7.7
403
3055
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.8
7.7
126
718
116
Kela drug reimbursment
Prostate cancer
1.6
7.6
183
1170
N13.9
ICD-10 Finland
Obstructive and reflux uropathy, unspecified
6.2
7.5
19
31
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.3
7.5
687
5704
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.4
7.5
466
3638
L89
ICD-10 Finland
Decubitus ulcer and pressure area
2.9
7.5
43
149
N39.3
ICD-10 Finland
Stress incontinence
2.4
7.5
59
248
T91.3
ICD-10 Finland
Sequelae of injury of spinal cord
7.1
7.5
17
24
L02BB04
ATC
enzalutamide; oral
3.6
7.5
31
86
KCF00
NOMESCO Finland
Cystotomy and removal of foreign body from bladder
80.4
7.4
8
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.6
7.3
212
1415
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.3
7.3
652
5385
R32
ICD-10 Finland
Unspecified urinary incontinence
3.0
7.3
40
137
7172
FHL
Ureterotomy, involves stone removal
+∞
7.3
7
*
KDE00
NOMESCO Finland
Urethrolithotomy
+∞
7.3
7
*
59404
ICD-8 Finland
NA
+∞
7.3
7
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.4
7.3
464
3635
KCV12
NOMESCO Finland
Urinary bladder endoscopic botulin therapy
4.9
7.3
22
45
K59.1
ICD-10 Finland
Functional diarrhoea
2.1
7.3
79
388
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.3
7.2
727
6116
M01AE03
ATC
ketoprofen; systemic, rectal
1.3
7.2
576
4684
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.4
7.1
458
3592
A02BC02
ATC
pantoprazole; systemic
1.3
7.1
978
8592
P01AB01
ATC
metronidazole; oral, rectal
1.4
7.0
491
3899
A03
ICPC
Fever
1.6
7.0
179
1160
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.7
7.0
160
1005
N02AA05
ATC
oxycodone; systemic
1.5
7.0
256
1809
N35.8
ICD-10 Finland
Other urethral stricture
6.3
6.9
17
27
TKE00
NOMESCO Finland
Needle biopsy of prostate
1.8
6.9
123
721
N13.0
ICD-10 Finland
Hydronephrosis with ureteropelvic junction obstruction
5.5
6.9
19
35
J01CA04
ATC
amoxicillin; systemic
1.3
6.9
1177
10631
KEC00
NOMESCO Finland
Retropubic radical prostatectomy
2.5
6.9
50
203
KCH42
NOMESCO Finland
Transurethral incision or resection of bladder neck
7.6
6.9
15
20
I10
ICD-10 Finland
Essential (primary) hypertension
1.3
6.9
1004
8868
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
2.1
6.9
75
367
SPAT1249
SPAT
Treatment-related counselling outside office
1.3
6.8
564
4594
N02AJ06
ATC
codeine and paracetamol; systemic
1.3
6.8
499
3993
P20
ICPC
Memory disturbance
1.5
6.8
216
1480
163
Kela drug reimbursment
Abiraterone and enzalutamide
3.0
6.7
36
122
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.0
6.7
87
456
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
2.1
6.7
70
338
WX110
NOMESCO Finland
Local anesthesy
1.3
6.7
965
8496
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
2.0
6.6
84
439
KA3GB
NOMESCO Finland
Retrograde pyelography
10.1
6.5
12
12
E21.0
ICD-10 Finland
Primary hyperparathyroidism
4.0
6.5
24
61
7451
FHL
Transurethral adenoma removal
2.7
6.4
42
160
59504
ICD-8 Finland
Cystitis, Interstitialis (Hunner)
70.1
6.4
7
*
M01AH01
ATC
celecoxib; oral (coxibs)
1.5
6.4
241
1707
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
1.9
6.4
83
437
SPAT1255
SPAT
Intravenous administration of medicine
1.8
6.4
111
643
QBG10
NOMESCO Finland
Excision and repair of bedsore of trunk
14.4
6.4
10
7
BB1BQ
NOMESCO Finland
Extensive scintigraphy of parathyroid gland, 2 isotopes, SPECT and low-dose CT
14.4
6.4
10
7
TPH04
NOMESCO Finland
Cathetrisation of vein
1.4
6.4
319
2392
109
Kela drug reimbursment
Multiple sclerosis
6.6
6.3
15
23
M79.6
ICD-10 Finland
Pain in limb
1.3
6.3
455
3627
TKW99
NOMESCO Finland
Other minor surgical procedure in urology
3.6
6.3
26
73
N86
ICPC
Multiple sclerosis
9.3
6.3
12
13
A02BC05
ATC
esomeprazole; systemic
1.3
6.3
546
4474
T81.8
ICD-10 Finland
Other complications of procedures, not elsewhere classified
2.9
6.3
34
117
59209
ICD-8 Finland
Calculus of kidney and ureter, Unspecified
+∞
6.3
6
*
KH1ZT
NOMESCO Finland
Removal of stone or foreign body from uringary tract with radiological guidance
+∞
6.3
6
*
KAE00
NOMESCO Finland
Nephrolithotomy
+∞
6.3
6
*
Q05.2
ICD-10 Finland
Lumbar spina bifida with hydrocephalus
+∞
6.3
6
*
G82.4
ICD-10 Finland
Spastic tetraplegia
26.8
6.2
8
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.4
6.2
410
3221
KCB00
NOMESCO Finland
Biopsy of bladder
5.4
6.2
17
32
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
2.1
6.1
64
311
8120/3-C67.9
ICD-O-3
Transitional cell carcinoma, NOS, of bladder, NOS
2.4
6.1
48
204
AA1AD
NOMESCO Finland
CT of head and brain
1.4
6.1
396
3099
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
1.8
6.1
101
578
SPAT1260
SPAT
Consultation of another employee
1.4
6.0
251
1814
KH1CB
NOMESCO Finland
Urography with X-ray
10.1
6.0
11
11
G82.5
ICD-10 Finland
Tetraplegia, unspecified
10.1
6.0
11
11
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.4
6.0
256
1860
SPAT1254
SPAT
Administration of medicine
1.5
6.0
229
1626

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
924
4317
3.15
133.75
5.9
3.1
—
—
—
0
0
342
876
4.52
123.22
2.8
2.8
—
—
—
0
0
1468
9985
2.86
90.09
8.6
4.4
615.6
1447.5
e6/l
0.57
50
189
697
3638
2.42
70.69
3.9
2.6
4.6
3.7
e6/l
1.52
616
3216
890
5175
2.32
70.20
5.6
3.4
203.6
96.9
e6/l
1.21
752
4098
955
5766
2.28
68.29
6.5
3.8
235.3
130.6
e6/l
1.62
783
4330
1435
10346
2.43
66.11
7.1
4.2
—
—
—
0
0
791
4664
2.16
57.22
5.2
3.3
0.3
0.5
e6/l
2.69
655
3607
750
4475
2.09
51.25
5.0
3.2
—
—
—
0
0
617
3427
2.17
50.78
4.4
2.8
618.1
573.3
mosm/kgh2o
5.36
534
2925
1051
7175
2.00
48.51
5.9
3.6
0.0
0.0
estimate
0.00
229
1395
870
5565
2.01
48.33
5.5
3.3
—
5.7
—
0
5
1044
7134
1.99
47.79
7.9
4.8
0.0
0.0
estimate
0.00
232
1417
1053
7221
1.99
47.67
5.3
4.5
—
—
—
0
0
1054
7256
1.98
46.89
6.0
3.6
0.0
0.0
estimate
0.38
226
1346
1286
9524
2.01
45.83
5.4
5.3
6.9
6.9
mmol/l
0.05
1237
9000
245
1006
2.64
39.35
5.0
2.9
0.2
0.3
e6/l
0.23
240
986
479
2687
2.03
36.56
5.1
3.1
1.6
1.0
e6/l
1.46
315
1565
689
4379
1.88
36.34
2.9
3.0
2789.1
6728.5
umol/l
2.11
596
3742
1085
7974
1.81
35.20
7.9
7.6
1.2
1.2
mmol/l
4.03
909
6680
493
2829
1.99
35.11
4.5
2.9
1.5
0.9
e6/l
2.59
330
1695
745
4974
1.80
32.69
2.8
2.7
—
—
—
0
0
611
3869
1.84
31.73
5.6
3.4
—
—
—
0
0
1702
14666
2.20
31.32
21.8
17.2
27.6
27.9
mg/l
0.17
1478
12001
1441
11804
1.83
29.79
8.7
8.0
80.3
80.9
u/l
0.17
1368
11098
756
5180
1.75
29.59
5.2
4.6
—
—
—
0
0
984
7264
1.71
29.29
6.8
6.6
1.2
1.2
mmol/l
5.90
896
6569
28
0
+∞
29.24
1.2
0.0
318.0
—
umol/24h
—
28
0
712
4894
1.71
26.93
2.8
2.7
64.5
57.9
u/l
0.53
665
4522
1081
8297
1.67
26.85
6.4
6.5
11.4
12.7
umol/l
4.72
1029
7889
1738
15381
2.13
25.36
25.1
20.3
140.0
139.6
mmol/l
8.39
1705
14967
1738
15418
2.10
24.61
25.2
20.5
4.0
4.0
mmol/l
3.30
1701
14983
921
6964
1.61
22.87
5.1
5.3
34.3
34.6
g/l
1.01
848
6474
601
4092
1.68
22.72
6.5
3.9
0.0
0.0
estimate
0.12
215
1295
221
1120
2.10
21.39
4.5
4.4
97.0
105.0
ng/l
0.43
197
982
346
2063
1.82
20.72
1.5
1.4
—
—
—
0
0
942
7273
1.57
20.63
10.8
11.6
1.2
1.4
inr
3.85
271
2051
373
2299
1.77
19.92
5.8
7.4
105.4
104.3
mmol/l
4.98
360
2237
257
1420
1.93
19.45
4.6
3.4
—
—
—
0
0
856
6540
1.55
19.18
4.7
4.1
44.8
61.3
ng/l
1.14
681
5042
372
2316
1.75
19.11
5.9
6.6
1.0
1.0
mmol/l
0.67
350
2157
1724
15551
1.89
18.80
25.9
20.2
89.7
87.8
umol/l
0.89
1724
15542
696
5095
1.57
18.77
3.2
3.4
2.4
2.3
mmol/l
1.86
602
4388
1174
9718
1.52
17.38
6.1
5.3
4.1
4.0
ug/l
0.04
1038
8621
664
4880
1.54
17.26
4.9
4.3
—
—
—
0
0
1671
15058
1.73
16.60
21.1
16.5
—
—
—
0
0
470
3251
1.59
15.71
6.8
4.0
1.0
1.0
kg/l
0.64
69
488
634
4697
1.52
15.51
4.8
4.3
7.4
7.4
ph
0.94
134
938
537
3839
1.55
15.50
2.6
2.6
—
—
—
0
0
1750
16080
1.81
14.92
31.3
24.9
7.2
7.0
e9/l
3.13
1701
15530
725
5555
1.48
14.92
2.4
2.1
73.8
77.0
nmol/l
2.39
628
4880
1749
16074
1.80
14.82
31.3
24.8
236.5
234.6
e9/l
0.57
1704
15594
1749
16077
1.80
14.77
31.2
24.7
91.4
91.7
fl
1.17
1725
15766
1749
16077
1.80
14.77
31.1
24.7
30.4
30.5
pg
3.61
1725
15766
1701
15515
1.72
14.76
12.2
11.1
27.1
27.3
u/l
0.05
1634
14847
1749
16079
1.80
14.74
31.3
24.8
4.5
4.5
e12/l
0.04
1698
15536
129
612
2.19
14.73
2.1
1.9
—
—
—
0
0
1749
16083
1.80
14.67
31.5
25.0
134.7
135.6
g/l
1.52
1726
15767
749
5820
1.46
14.15
2.3
2.2
—
—
—
0
0
1275
10971
1.46
13.86
4.3
4.0
14.0
13.4
mm/h
0.60
1154
10054
1456
12880
1.50
13.60
4.2
4.2
1.9
2.1
mu/l
1.12
1275
11509
153
805
1.98
13.26
5.8
3.6
—
—
—
0
0
468
3377
1.51
12.53
5.6
3.5
—
—
—
0
0
12
0
+∞
12.51
1.1
0.0
—
—
—
0
0
536
3988
1.47
12.30
4.2
4.2
86.3
83.0
%
2.22
525
3901
209
1251
1.75
12.04
3.8
3.7
7.4
7.4
ph
1.36
28
155
210
1268
1.73
11.73
3.9
3.7
5.1
5.1
kpa
0.01
198
1162
1029
8693
1.39
11.23
8.9
8.9
4.7
4.4
e9/l
2.85
907
7571
213
1313
1.70
11.02
6.2
3.7
—
—
—
0
0
878
7258
1.38
10.78
6.5
6.1
25.0
25.9
%
1.21
814
6747
44
145
3.08
10.65
2.3
1.9
1.6
1.8
u/field
0.14
21
48
493
3701
1.44
10.55
6.6
6.6
—
—
—
0
0
10
0
+∞
10.42
1.1
0.0
2.1
—
mmol/24h
—
10
0
31
84
3.73
10.15
3.0
1.5
5.4
3.2
u/field
0.38
20
56
860
7142
1.36
10.01
6.2
5.9
59.7
58.7
%
1.49
801
6673
676
5404
1.38
9.98
4.1
4.1
14.9
9.9
mg/mmol
0.68
500
3620
381
2766
1.47
9.62
3.1
3.3
0.8
0.8
mmol/l
0.74
349
2588
11
11
10.05
9.55
1.3
1.2
—
—
—
0
0
94
470
2.05
9.44
6.8
4.1
—
—
—
0
0
855
7140
1.35
9.41
6.5
6.2
8.7
9.0
%
1.86
793
6673
165
997
1.72
9.18
3.7
2.9
—
—
—
0
0
1421
12846
1.38
9.16
20.7
18.2
39.1
39.4
%
0.46
848
8319
850
7112
1.34
9.15
6.3
5.9
2.8
2.9
%
0.73
786
6615
94
476
2.02
9.12
2.6
3.1
7.9
7.8
kpa
0.25
87
439
830
6923
1.34
9.11
6.3
6.0
0.6
0.6
%
2.04
768
6454
244
1632
1.57
9.06
4.5
4.7
—
—
—
0
0
84
409
2.10
9.06
2.6
2.9
—
—
—
0
0
60
254
2.41
9.03
2.8
4.1
—
—
—
0
0
105
555
1.94
9.03
3.3
3.3
25.0
24.8
mmol/l
0.19
94
484
259
1759
1.54
8.98
4.5
3.8
5.7
5.9
kpa
1.64
250
1698
259
1760
1.54
8.96
4.5
3.8
1.5
1.9
mmol/l
1.03
206
1380
390
2895
1.43
8.67
3.2
3.2
2.5
2.4
mmol/l
1.24
342
2538
56
238
2.39
8.38
1.5
1.4
—
—
—
0
0
1549
14280
1.40
8.31
5.2
4.9
6.2
6.1
mmol/l
1.01
1367
12780
240
1631
1.54
8.28
1.4
1.3
—
—
—
0
0
650
5286
1.34
8.24
5.9
5.7
—
—
—
0
0
24
64
3.78
8.07
1.8
2.9
—
—
—
0
0
1152
10184
1.32
8.00
3.4
3.4
15.0
14.9
pmol/l
0.17
1008
9034
237
1619
1.53
7.98
5.5
7.4
1.3
1.4
mmol/l
1.57
228
1555
677
5566
1.33
7.89
3.3
3.2
0.9
0.8
ug/l
0.70
493
3931
616
5001
1.34
7.81
2.3
2.2
180.9
267.5
u/l
1.80
575
4689
899
7700
1.31
7.78
6.3
5.7
2.0
1.9
e9/l
0.35
796
6721
445
3441
1.38
7.72
1.9
1.8
1128.7
1178.0
nmol/l
0.47
323
2593
257
1799
1.49
7.70
2.8
2.8
7.0
10.6
umol/l
3.09
227
1601
146
896
1.68
7.69
3.9
3.8
—
—
—
0
0
883
7562
1.30
7.58
6.2
5.6
0.0
0.0
e9/l
0.28
773
6494
907
7803
1.30
7.50
6.3
5.8
0.2
0.2
e9/l
0.24
798
6807
155
975
1.64
7.43
3.1
3.4
4.5
4.3
e9/l
0.42
111
726
657
5423
1.32
7.32
3.1
3.2
1714.9
1974.7
ng/l
0.63
568
4742
205
1383
1.54
7.31
2.7
2.5
30.7
72.0
u/l
0.63
178
1175
876
7519
1.30
7.30
6.2
5.6
0.6
0.6
e9/l
0.13
767
6450
202
1369
1.53
7.05
2.7
2.3
218.8
171.8
ug/g
0.64
163
1081
199
1347
1.53
6.99
3.8
4.3
1.2
1.2
mmol/l
3.47
175
1181
211
1450
1.51
6.90
3.7
3.1
4.6
4.5
kpa
0.23
203
1398
1489
13767
1.34
6.88
7.2
6.4
41.5
40.9
mmol/mol
1.46
1356
12579
1567
14619
1.35
6.67
5.3
5.2
2.5
2.6
mmol/l
0.71
1410
13256
401
3117
1.36
6.63
1.7
1.7
1.3
1.5
mg/l
0.56
315
2430
772
6582
1.28
6.56
12.7
10.3
0.0
0.0
e9/l
0.49
650
5380
32
117
2.76
6.55
3.6
2.9
—
—
—
0
0
633
5273
1.30
6.41
3.5
3.3
8.2
7.9
mmol/l
1.32
514
4362
50
230
2.20
6.31
6.6
7.4
7.4
7.6
mmol/l
0.10
40
194
616
5131
1.29
6.20
3.3
3.4
77.2
274.6
mg/l
4.23
463
3492
782
6712
1.27
6.20
2.2
2.1
89.4
92.0
pmol/l
0.84
478
3731
1186
10713
1.27
6.10
4.4
4.3
—
—
—
0
0
1528
14262
1.32
6.04
4.9
4.7
4.3
4.4
mmol/l
2.30
1392
13032
27
96
2.84
5.84
1.6
1.4
1512.3
1841.3
ml
—
6
26
264
1963
1.40
5.69
1.9
1.7
—
—
—
0
0
357
2803
1.33
5.45
1.8
2.0
30.0
30.3
s
0.53
349
2713
335
2613
1.34
5.34
23.5
28.9
1.4
1.5
inr
0.42
49
365
211
1530
1.42
5.25
7.6
8.9
—
—
—
0
0
1509
14141
1.29
5.25
4.8
4.6
1.3
1.4
mmol/l
4.28
1360
12801
5
0
+∞
5.21
1.2
0.0
—
—
—
0
0
101
626
1.65
5.20
3.0
3.1
0.4
0.3
g/l
0.69
46
276
15
40
3.77
5.09
1.1
1.2
—
—
—
0
0
60
322
1.89
5.06
2.6
2.3
—
—
—
0
0
73
417
1.78
5.05
2.4
2.2
131.3
129.3
g/l
0.24
55
312
477
3937
1.28
5.00
1.5
1.3
—
—
—
0
0
1277
11768
1.24
4.93
25.8
20.6
14.0
13.9
%
1.36
1255
11497
26
102
2.57
4.72
1.2
1.2
12.9
12.7
mmol/l
0.04
11
38
263
2017
1.35
4.68
1.2
1.3
—
—
—
0
0
519
4363
1.26
4.62
2.2
2.2
3.2
3.0
mg/l
0.80
433
3703
1460
13708
1.25
4.51
4.3
4.2
1.3
1.3
mmol/l
1.83
1303
12335
66
383
1.75
4.37
4.2
3.3
25.8
31.9
mg/l
0.66
43
253
434
3602
1.26
4.28
1.9
1.7
27325961.8
29865278.5
pmol/l
0.03
344
2960
699
6116
1.22
4.24
3.1
2.9
154.3
176.5
ug/l
1.28
608
5582
111
741
1.53
4.23
4.4
4.1
24.6
24.7
mmol/l
0.15
105
683
128
884
1.48
4.15
2.1
1.9
2.8
3.1
ug/l
0.13
112
769
75
458
1.66
4.15
3.0
4.0
—
—
—
0
0
70
423
1.68
4.04
2.4
2.5
16.8
16.1
%
0.77
46
225
29
133
2.20
3.80
1.5
1.5
—
—
—
0
0
98
653
1.53
3.80
3.0
3.3
43.5
7677.9
u/ml
1.08
83
554
67
409
1.66
3.74
1.4
1.5
262.5
261.8
ug/g
0.01
36
267
39
203
1.94
3.68
3.7
4.4
—
—
—
0
0
229
1784
1.32
3.67
4.5
4.2
5.0
23.8
ug/l
2.49
189
1513
476
4054
1.23
3.67
1.7
1.6
19.1
19.3
nmol/l
0.11
391
3468
68
423
1.63
3.55
1.8
1.6
—
—
—
0
0
107
743
1.47
3.43
1.3
1.3
—
—
—
0
0
13
42
3.11
3.37
1.8
1.7
—
—
—
0
0
203
1576
1.32
3.35
2.2
2.2
0.2
0.2
g/l
0.47
178
1457
31
156
2.00
3.25
1.1
1.3
—
—
—
0
0
298
2445
1.26
3.21
2.1
2.1
—
—
—
0
0
8
16
5.02
3.05
1.6
1.3
—
—
—
0
0
8
16
5.02
3.05
1.6
1.4
—
—
—
0
0
74
490
1.53
3.01
4.3
3.6
—
—
—
0
0
118
857
1.40
3.00
4.5
4.0
23.7
24.0
mmol/l
0.55
110
757
166
1275
1.33
2.97
4.0
4.2
0.0
0.1
%
2.13
62
419
206
1631
1.29
2.96
2.1
2.2
11.5
12.6
nmol/l
0.97
179
1407
14
52
2.70
2.89
1.9
2.6
—
—
—
0
0
1255
11819
1.17
2.85
26.7
22.2
332.1
332.8
g/l
1.80
1239
11704
29
151
1.93
2.80
1.1
1.3
—
—
nmol/l
—
0
0
30
160
1.89
2.71
1.9
1.8
—
—
—
0
0
30
160
1.89
2.71
3.2
2.1
7219.1
2253.2
u/l
0.31
13
57
263
2171
1.24
2.69
7.4
7.8
0.9
1.2
mmol/l
0.54
208
1657
173
1357
1.30
2.69
3.9
4.1
0.9
0.8
%
0.12
66
455
51
319
1.61
2.68
2.8
3.8
1.0
1.6
%
0.95
40
243
119
885
1.37
2.66
3.5
2.6
1.3
1.2
%
0.75
119
879
221
1792
1.26
2.64
8.1
8.7
120.7
121.6
g/l
0.26
215
1729
30
162
1.87
2.62
1.2
1.3
327.0
253.3
pmol/l
0.50
23
124
243
1997
1.25
2.59
7.6
8.1
95.3
95.3
%
0.01
236
1920
153
1190
1.31
2.54
4.1
4.2
0.3
0.1
%
0.31
56
346
41
246
1.68
2.54
3.7
2.6
—
—
—
0
0
18
82
2.21
2.47
1.9
1.2
—
—
—
0
0
272
2276
1.23
2.46
2.8
2.4
1.7
1.8
%
0.35
239
2019
211
1724
1.25
2.38
1.3
1.3
489.1
466.9
titre
0.06
44
362
217
1780
1.25
2.37
7.0
7.5
10.8
11.2
mmol/l
0.42
202
1684
7
17
4.13
2.36
10.3
2.5
0.1
0.4
u/field
—
7
17
381
3309
1.19
2.34
4.0
4.1
464.9
776.0
ng/l
0.47
295
2831
45
284
1.60
2.32
1.5
1.3
—
—
—
0
0
302
2572
1.21
2.30
1.2
1.2
1.4
1.9
u/ml
0.45
86
660
6
13
4.63
2.27
1.0
1.2
—
—
—
0
0
19
93
2.05
2.21
1.1
1.1
—
—
—
0
0
323
2778
1.19
2.21
2.8
2.7
11.8
12.6
umol/l
1.05
286
2588
259
2182
1.22
2.21
7.5
7.8
5.1
5.1
kpa
0.04
248
2084
259
2182
1.22
2.21
7.5
7.8
12.1
11.8
kpa
0.40
249
2086
153
1215
1.28
2.20
3.6
4.0
0.5
0.5
%
0.12
47
319
22
115
1.92
2.15
2.1
2.9
7.4
7.4
ph
—
7
41
49
329
1.50
1.97
1.4
1.4
11.5
8.3
u/l
1.04
42
267
97
737
1.33
1.96
1.2
1.4
—
—
—
0
0
27
157
1.73
1.93
4.4
3.8
—
—
—
0
0
21
113
1.87
1.91
2.0
2.3
—
—
—
0
0
13
58
2.25
1.91
2.2
2.2
—
—
—
0
0
58
408
1.43
1.86
1.7
1.6
11528.0
17035.2
e6/l
0.80
42
285
107
832
1.30
1.85
2.2
2.4
—
—
—
0
0
241
2055
1.20
1.83
1.3
1.3
76.3
34.9
iu/ml
0.82
62
637
5
12
4.17
1.82
1.0
1.2
—
—
—
0
0
285
2468
1.18
1.82
3.0
2.7
21.9
23.0
%
0.54
236
2110
25
145
1.73
1.81
1.2
1.3
—
—
—
0
0
38
571
0.66
1.80
1.4
1.5
—
—
—
0
0
9
35
2.58
1.80
1.7
1.3
—
—
—
0
0
32
200
1.61
1.77
2.7
3.8
62.1
56.5
%
0.62
22
126
503
4556
1.14
1.76
3.6
3.1
—
—
—
0
0
52
363
1.44
1.76
1.3
1.1
—
—
—
0
0
124
992
1.27
1.73
7.6
10.1
24.0
24.3
mmol/l
0.35
112
925
203
1714
1.21
1.73
2.5
2.5
66.7
68.3
e9/l
0.32
160
1331
83
631
1.33
1.70
1.2
1.2
—
—
—
0
0
62
450
1.39
1.70
2.7
2.9
1.6
1.7
mg/l
0.99
55
397
202
1708
1.20
1.69
2.8
2.4
6.5
7.4
ug/l
0.32
158
1503
81
616
1.33
1.66
2.8
3.3
4.4
4.4
pmol/l
0.06
71
539
44
301
1.47
1.66
1.4
1.5
—
—
—
0
0
18
98
1.84
1.61
1.1
1.2
—
—
—
0
0
112
894
1.27
1.61
1.6
1.4
—
—
—
0
0
12
56
2.15
1.61
1.0
1.1
—
—
—
0
0
27
167
1.63
1.58
1.3
1.2
—
—
—
0
0
33
215
1.54
1.57
1.1
1.2
—
—
—
0
0
295
2596
1.16
1.56
2.8
2.7
2.2
2.2
g/l
0.08
263
2407
19
107
1.78
1.54
1.7
1.5
—
—
—
0
0
424
3830
1.14
1.54
1.7
1.6
1.4
1.4
mmol/l
0.54
334
3145
44
307
1.44
1.52
3.1
3.7
57.9
58.7
%
0.11
44
307
66
498
1.34
1.46
3.2
5.0
7.4
7.4
ph
0.08
56
425
158
1332
1.20
1.40
1.3
1.4
—
—
—
0
0
275
2428
1.15
1.40
1.3
1.5
2.6
2.7
g/l
0.50
165
1506
12
60
2.01
1.38
1.3
1.3
1858.7
55.8
ug/l
—
7
24
12
60
2.01
1.38
1.8
1.7
—
—
—
0
0
151
1273
1.20
1.35
2.5
2.2
349.6
369.0
nmol/l
0.58
142
1157
9
42
2.15
1.33
1.1
1.5
—
—
—
0
0
19
114
1.67
1.28
1.2
2.4
6.8
7.0
mmol/l
0.11
12
72
103
841
1.24
1.27
1.1
1.3
—
—
—
0
0
145
1226
1.20
1.27
10.3
7.3
24.4
24.4
mmol/l
0.02
137
1147
35
244
1.44
1.26
1.4
1.3
30.5
24.1
iu/l
0.50
29
204
168
1442
1.18
1.25
1.8
1.6
—
—
—
0
0
57
433
1.33
1.24
3.2
5.3
2.2
2.6
mmol/l
0.56
40
291
52
390
1.34
1.23
2.7
3.0
—
—
—
0
0
29
197
1.48
1.19
1.7
1.5
66.6
64.9
%
0.08
18
128
8
38
2.11
1.18
1.0
1.1
—
—
—
0
0
8
38
2.11
1.18
1.0
1.1
—
—
—
0
0
8
38
2.11
1.18
1.0
1.1
—
—
—
0
0
0
35
0.00
1.15
0.0
1.5
—
—
—
0
0
7
30
2.34
1.12
3.3
6.3
—
—
—
0
0
26
177
1.48
1.08
1.1
1.1
—
—
—
0
0
100
832
1.21
1.07
1.5
1.3
71.1
54.3
au/ml
—
6
35
28
194
1.45
1.07
1.5
1.7
0.6
1.0
g/l
1.33
13
154
16
98
1.64
1.03
1.3
1.5
—
—
—
0
0
212
1884
1.14
1.03
1.8
1.7
—
—
—
0
0
7
34
2.06
1.03
1.1
1.1
—
—
—
0
0
19
122
1.56
1.02
1.8
1.4
1.6
1.1
promille
0.65
12
99
26
180
1.45
1.00
1.0
1.2
—
—
—
0
0
16
99
1.62
1.00
2.2
2.6
—
—
—
0
0
68
549
1.25
0.98
1.9
1.9
20.9
21.8
s
1.11
57
495
24
165
1.46
0.97
1.7
1.3
103388.1
116312.9
e6/l
0.05
18
112
19
124
1.54
0.96
1.3
1.1
—
65.7
—
0
5
119
1019
1.18
0.95
8.6
11.0
—
—
—
0
0
8
142
0.56
0.93
1.3
1.3
—
—
—
0
0
80
662
1.22
0.93
1.3
1.2
—
—
—
0
0
77
636
1.22
0.91
2.9
3.6
47.2
66.0
mg/l
0.98
63
500
6
28
2.15
0.91
1.0
1.1
—
—
—
0
0
15
94
1.60
0.90
2.7
1.5
17.2
15.7
nmol/l
0.35
15
84
36
271
1.33
0.89
1.5
1.4
—
—
—
0
0
179
1592
1.14
0.88
1.8
1.6
—
—
—
0
0
6
30
2.00
0.87
14.5
11.1
5.1
5.9
mmol/l
—
6
30
20
136
1.48
0.86
1.4
1.2
—
—
—
0
0
62
505
1.24
0.85
2.2
2.4
218.5
117.0
ug/min
0.34
31
309
76
635
1.20
0.83
2.9
3.6
43.3
73.8
mg/l
0.74
63
503
84
711
1.19
0.80
1.2
1.3
199.3
270.3
u/ml
0.74
79
655
38
295
1.29
0.78
3.1
3.3
4.8
4.5
e9/l
0.36
38
295
32
243
1.32
0.77
1.4
1.2
—
—
—
0
0
149
1324
1.14
0.77
2.1
2.5
—
—
—
0
0
75
632
1.19
0.76
1.2
1.2
148.9
135.6
iu/ml
0.10
27
225
24
176
1.37
0.72
1.5
1.2
—
—
—
0
0
20
142
1.41
0.72
2.7
2.4
—
—
—
0
0
216
1973
1.11
0.71
1.3
1.3
15.0
12.0
u/ml
0.20
74
735
9
58
1.55
0.69
1.6
1.7
—
—
—
0
0
131
1165
1.13
0.69
9.9
9.9
94.4
93.8
%
0.66
131
1158
68
575
1.19
0.68
7.3
4.2
4.0
4.0
mmol/l
0.42
55
532
35
275
1.28
0.68
1.9
2.6
—
—
—
0
0
27
206
1.32
0.65
1.2
1.3
—
—
—
0
0
21
154
1.37
0.65
2.2
1.3
29.0
23.1
%
0.31
13
94
12
79
1.52
0.62
3.9
3.4
—
—
—
0
0
17
121
1.41
0.62
1.7
1.3
0.4
0.4
g/l
—
8
87
17
121
1.41
0.62
1.7
1.3
3.1
3.0
g/l
—
8
87
17
121
1.41
0.62
1.7
1.3
5.1
7.2
g/l
—
8
88
198
1820
1.10
0.60
1.4
1.4
—
—
—
0
0
27
211
1.28
0.57
3.2
4.6
289.6
345.6
umol/l
1.83
20
186
38
312
1.22
0.54
1.4
1.4
48.5
35.1
e6/l
0.14
27
244
38
312
1.22
0.54
1.5
1.4
1337.9
666.4
e6/l
0.28
30
252
30
240
1.25
0.54
1.1
1.1
—
—
—
0
0
26
205
1.27
0.52
2.5
2.5
—
—
—
0
0
51
435
1.18
0.50
1.6
2.8
26.3
34.4
umol/l
3.23
38
354
334
3162
1.07
0.50
5.8
4.6
—
—
—
0
0
37
306
1.21
0.50
1.7
1.4
—
—
—
0
0
6
41
1.46
0.50
1.0
1.0
—
—
—
0
0
15
110
1.37
0.48
2.5
2.4
—
—
—
0
0
7
111
0.63
0.48
1.1
1.3
—
33.4
—
0
5
12
85
1.41
0.47
3.9
3.3
—
—
—
0
0
32
264
1.22
0.46
1.6
1.3
—
—
—
0
0
5
81
0.62
0.45
1.2
1.6
6.3
8.4
u/l
—
5
71
30
246
1.22
0.45
1.8
2.3
—
—
—
0
0
14
103
1.36
0.45
4.8
3.8
—
—
—
0
0
175
1626
1.08
0.45
2.7
3.1
288.7
254.0
ng/l
0.29
161
1496
77
686
1.13
0.44
1.5
1.6
—
—
—
0
0
12
87
1.38
0.42
1.3
1.4
—
—
—
0
0
12
87
1.38
0.42
1.3
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
55
483
1.14
0.40
2.7
3.9
—
—
—
0
0
16
123
1.30
0.40
1.8
1.3
—
—
—
0
0
5
34
1.47
0.40
1.0
1.1
—
—
—
0
0
8
60
1.33
0.40
1.3
1.6
1.3
12.7
nmol/l
—
8
51
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
8
61
1.31
0.39
1.9
2.5
—
—
—
0
0
13
97
1.34
0.39
4.8
3.4
12.6
13.2
%
2.90
13
97
5
35
1.43
0.39
1.2
1.4
—
—
—
0
0
51
448
1.14
0.38
1.2
1.2
0.2
1.0
u/ml
—
5
43
9
71
1.27
0.36
1.1
1.4
2.9
3.8
mmol/l
—
9
63
31
263
1.18
0.36
1.3
1.2
377.4
282.8
u/ml
0.53
16
153
12
90
1.34
0.35
1.5
1.5
—
—
—
0
0
28
237
1.18
0.33
1.6
1.6
2.5
5.0
iu/l
—
10
68
142
1329
1.07
0.33
6.7
5.0
—
—
—
0
0
127
1184
1.08
0.33
3.0
2.8
10.7
10.9
g/l
0.13
117
1082
13
166
0.78
0.33
1.2
1.1
—
11.6
—
0
10
104
962
1.09
0.33
1.5
1.7
1.5
1.5
g/l
0.08
90
823
43
380
1.13
0.31
1.1
1.2
—
—
—
0
0
7
53
1.32
0.30
1.0
1.3
—
—
—
0
0
12
93
1.29
0.30
1.1
1.1
—
—
—
0
0
168
1592
1.06
0.29
2.1
2.6
66.8
66.2
g/l
0.34
150
1455
7
57
1.23
0.29
1.3
1.8
—
—
—
0
0
13
103
1.26
0.28
1.2
1.3
—
—
—
0
0
17
140
1.22
0.27
1.1
1.2
—
—
—
0
0
119
1264
0.94
0.26
1.5
1.5
—
—
—
0
0
8
67
1.19
0.26
29.3
28.9
96.3
116.0
ug/l
—
8
60
5
73
0.68
0.26
1.2
1.2
—
—
—
0
0
47
425
1.11
0.25
1.6
1.7
—
—
—
0
0
27
235
1.15
0.25
1.1
1.1
—
—
—
0
0
9
75
1.20
0.25
1.8
2.0
876.2
1232.3
u/ml
—
9
75
13
105
1.24
0.24
1.3
1.6
—
—
—
0
0
17
142
1.20
0.24
1.2
1.2
—
—
—
0
0
20
171
1.17
0.23
1.4
1.2
—
—
—
0
0
13
106
1.23
0.23
1.9
1.6
—
74.7
—
0
7
5
39
1.28
0.23
1.4
1.3
—
—
—
0
0
48
438
1.10
0.22
1.0
1.1
—
—
—
0
0
42
381
1.10
0.22
1.3
1.2
—
—
—
0
0
116
1100
1.06
0.21
1.3
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
2.1
—
1.8
—
0
11
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
37
408
0.91
0.21
3.4
3.0
0.7
0.9
nmol/l
1.42
25
309
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
1.7
—
0
5
14
117
1.20
0.20
1.6
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
9
112
0.80
0.20
1.6
1.7
—
—
—
0
0
28
251
1.12
0.18
1.4
1.6
—
—
—
0
0
7
60
1.17
0.17
1.0
1.3
34.3
22.7
%
—
7
45
7
60
1.17
0.17
7.0
7.4
—
—
—
0
0
18
157
1.15
0.17
2.3
2.2
584.0
648.3
ml
—
10
94
23
205
1.12
0.17
1.3
1.5
—
—
—
0
0
23
205
1.12
0.17
1.3
1.5
—
—
—
0
0
23
205
1.12
0.17
1.3
1.5
—
—
—
0
0
23
205
1.12
0.17
1.3
1.5
—
—
—
0
0
5
68
0.73
0.17
1.0
1.3
—
—
—
0
0
8
68
1.18
0.16
1.5
1.3
13.2
9.8
ug/l
—
8
57
21
187
1.12
0.16
1.1
1.2
—
—
—
0
0
29
264
1.10
0.15
1.9
1.4
93.0
126.4
u/ml
—
6
49
12
102
1.18
0.15
1.1
1.4
—
—
—
0
0
18
202
0.89
0.14
8.7
2.1
—
—
—
0
0
35
378
0.92
0.14
1.8
1.7
—
—
—
0
0
60
567
1.06
0.14
2.1
2.3
37.3
37.5
g/l
0.08
50
491
20
222
0.90
0.13
1.6
1.5
—
—
—
0
0
146
1414
1.04
0.13
1.6
1.6
—
—
—
0
0
15
132
1.14
0.13
1.5
1.8
13.1
10.8
%
0.94
15
132
14
123
1.14
0.12
1.0
1.1
—
—
—
0
0
37
347
1.07
0.11
1.8
1.6
—
—
—
0
0
76
791
0.96
0.11
1.2
1.4
—
—
—
0
0
12
105
1.14
0.11
2.0
2.1
644.2
668.3
e6/l
—
5
45
23
249
0.92
0.10
7.5
1.9
—
—
—
0
0
27
290
0.93
0.10
1.6
1.3
59.9
65.3
mmol/l
0.32
15
236
28
261
1.07
0.10
1.0
1.3
—
—
—
0
0
37
349
1.06
0.10
1.0
1.1
—
—
—
0
0
79
762
1.04
0.10
5.6
4.7
—
—
—
0
0
5
45
1.11
0.09
1.0
1.1
1550.4
1501.7
miu/ml
—
5
45
5
46
1.09
0.09
1.8
2.4
—
—
—
0
0
30
282
1.06
0.09
1.4
1.4
4965.9
1858.3
e6/l
0.60
22
205
35
331
1.06
0.09
1.1
1.2
91.6
49.8
u/l
0.28
29
292
15
136
1.10
0.08
1.4
1.4
—
—
—
0
0
5
61
0.82
0.08
1.0
1.3
—
0.1
—
0
7
5
64
0.78
0.08
3.2
1.2
50.1
61.7
%
—
5
53
7
68
1.03
0.07
1.0
1.1
—
—
—
0
0
6
70
0.86
0.07
1.2
1.0
—
—
—
0
0
6
72
0.83
0.07
8.5
7.4
22.5
24.7
mmol/l
—
6
65
8
75
1.07
0.07
1.3
1.4
29.9
24.8
%
—
8
67
22
235
0.94
0.07
7.4
2.1
—
—
—
0
0
34
357
0.95
0.07
1.5
1.6
—
—
—
0
0
97
947
1.03
0.07
1.7
2.0
1.1
1.5
g/l
1.64
84
860
14
128
1.09
0.06
2.5
2.3
—
—
—
0
0
8
95
0.84
0.06
1.1
1.2
—
—
—
0
0
12
132
0.91
0.06
1.1
1.0
3.1
5.8
u/ml
—
6
63
24
254
0.94
0.06
7.0
2.0
—
—
—
0
0
24
254
0.94
0.06
7.5
2.0
—
—
—
0
0
18
168
1.07
0.06
8.9
3.1
—
—
—
0
0
19
178
1.07
0.05
1.4
1.2
1.9
5.3
u/ml
—
8
85
37
384
0.96
0.05
1.1
1.1
—
—
—
0
0
11
120
0.92
0.05
10.2
2.7
—
—
—
0
0
24
252
0.95
0.05
7.3
2.0
—
—
—
0
0
16
150
1.07
0.04
1.2
1.1
—
—
—
0
0
16
150
1.07
0.04
1.2
1.1
—
—
—
0
0
27
259
1.04
0.04
1.4
1.4
102011.5
88937.1
e6/l
0.08
20
160
28
269
1.04
0.04
1.3
2.9
36.8
61.6
u/ml
0.65
28
256
15
142
1.06
0.02
3.1
2.3
1.4
1.0
e9/l
—
9
83
15
142
1.06
0.02
1.4
1.2
—
71.1
—
0
8
17
178
0.95
0.02
1.2
1.3
16.5
15.1
u/l
0.08
17
166
90
911
0.99
0.02
1.1
1.2
—
—
—
0
0
26
252
1.03
0.02
1.4
1.5
—
—
—
0
0
49
497
0.99
0.01
15.1
11.3
—
—
—
0
0
14
146
0.96
0.00
1.1
1.3
—
—
—
0
0
17
165
1.03
0.00
1.1
1.4
294.3
278.5
mosm/kgh2o
0.98
12
117
13
131
0.99
0.00
1.0
1.2
—
—
—
0
0
10
104
0.96
0.00
1.1
1.5
12.7
14.6
umol/l
—
10
96
21
214
0.98
0.00
1.5
2.2
—
—
—
0
0
13
127
1.02
0.00
1.0
1.0
1.0
2.2
u/ml
—
5
51
17
173
0.98
0.00
1.5
1.6
—
—
—
0
0
9
89
1.01
0.00
1.1
1.2
156.0
138.4
nmol/l
—
9
89
9
96
0.94
0.00
1.6
2.4
0.3
0.2
e9/l
—
9
85
8
87
0.92
0.00
1.3
1.5
0.4
2.2
%
—
8
71
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
94.6
—
0
7
0
5
0.00
0.00
0.0
1.0
—
37.0
—
0
5
7
72
0.97
0.00
1.1
1.1
117.7
243.1
iu/ml
—
7
72
0
9
0.00
0.00
0.0
8.1
—
—
—
0
0
5
53
0.94
0.00
6.2
2.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
57
0.88
0.00
1.0
1.3
—
—
—
0
0
6
61
0.98
0.00
1.0
1.1
—
11.6
—
0
16
0
7
0.00
0.00
0.0
8.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
10
100
1.00
0.00
7.8
15.8
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint N14_CALCULOWER and mortality.

Females

Parameter HR [95% CI] p-value
N14_CALCULOWER 1.812 [1.52, 2.16] < 0.001
Birth year 0.987 [0.98, 1.0] 0.008

During the follow-up period (1.1.1998 — 31.12.2019), 398 out of 1853 females with N14_CALCULOWER died.

Males

Parameter HR [95% CI] p-value
N14_CALCULOWER 1.241 [1.11, 1.38] < 0.001
Birth year 0.98 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 2580 out of 8052 males with N14_CALCULOWER died.

Mortality risk

Mortality risk for people of age

years, who have N14_CALCULOWER.

N-year risk Females Males
1 0.133% 0.16%
5 0.89% 1.114%
10 2.155% 2.884%
15 4.038% 5.312%
20 6.862% 8.746%

Relationships between endpoints

Index endpoint: N14_CALCULOWER – Calculus of lower urinary tract

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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