No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1219 |
4. Check minimum number of eventsNone |
1219 |
5. Include endpointsNone |
1219 |
6. Filter based on genotype QC (FinnGen only) |
1219 |
Control definitions (FinnGen only)
- Control exclude
- ASTHMA_SEPTICHE_PNEUMONIA
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- A40
- Name in latin
- Septic(h)aemia pneumococcica
Similar endpoints
↥List of similar endpoints to
Pneumococcal septicemia
based on the number of shared cases.
Similar with more cases:
- Pneumonia derived septicemia
- Septicaemia
- Other bacterial diseases
- COPD/asthma related pneumonia or pneumonia derived septicaemia
- COPD/asthma/ILD related pneumonia or pneumonia derived septicaemia
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 14540 | 6399 | 8046 |
| Only index persons | 12041 | 5409 | 6632 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.21 | 0.18 | 0.22 |
| Only index persons | 0.23 | 0.20 | 0.25 |
| Median age at first event (years) | |||
| Whole population | 40.52 | 39.46 | 41.06 |
| Only index persons | 36.59 | 36.71 | 36.49 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1219 | 550 | 669 |
| Unadjusted period prevalence (%) | 0.25 | 0.19 | 0.29 |
| Median age at first event (years) | 57.83 | 52.83 | 61.94 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1064
- Matched controls
- 10641
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J13
ICD-10 Finland
Pneumonia due to Streptococcus pneumoniae
295.7
323.0
381
20
A40.3
ICD-10 Finland
Sepsis due to Streptococcus pneumoniae
4503599627370496.0
323.0
927
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
9.7
242.0
663
1547
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
8.6
122.4
295
455
0382A
ICD-9 Finland
Septicaemia, Pneumococcal septicaemia
+∞
101.7
96
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.3
69.9
304
899
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.0
62.9
594
3150
A41.9
ICD-10 Finland
Sepsis, unspecified
9.4
59.8
129
154
J01MA14
ATC
moxifloxacin; systemic
5.2
57.5
196
442
J01MA12
ATC
levofloxacin; systemic
3.4
52.3
307
1132
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.0
43.7
197
576
03820
ICD-8 Finland
Septicaemia, Pneumococcal
+∞
43.0
41
*
R50.9
ICD-10 Finland
Fever, unspecified
3.2
40.0
241
882
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
34.3
284
1264
R03AK06
ATC
salmeterol and fluticasone; inhalant
3.1
33.4
205
753
J86.9
ICD-10 Finland
Pyothorax without fistula
19.7
32.5
49
26
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
5.5
30.9
95
186
G00.1
ICD-10 Finland
Pneumococcal meningitis
159.4
29.8
31
*
H02AB06
ATC
prednisolone; systemic
2.1
28.3
518
3329
C03CA01
ATC
furosemide; systemic
2.3
28.0
347
1878
R03BB04
ATC
tiotropium bromide; inhalant
3.3
28.0
156
531
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.7
27.4
220
948
WX872
NOMESCO Finland
Intensive care
4.5
25.5
95
229
J01FF01
ATC
clindamycin; systemic
2.2
25.4
318
1713
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.0
25.3
560
3821
R81
ICPC
Pneumonia
5.8
25.2
73
133
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.2
24.9
144
500
WX892
NOMESCO Finland
Monitored bed care
3.5
24.8
123
382
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
3.0
24.5
155
571
J01CA04
ATC
amoxicillin; systemic
2.2
24.0
862
7032
J18.1
ICD-10 Finland
Lobar pneumonia, unspecified
11.4
24.0
45
41
C90.0
ICD-10 Finland
Multiple myeloma
12.8
23.7
42
34
TPH07
NOMESCO Finland
Cathetrisation of artery
2.9
23.6
154
579
9732/3-C42.1
ICD-O-3
Plasma cell myeloma of bone marrow
21.9
23.5
34
16
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.3
23.2
243
1196
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
4.8
22.6
78
174
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
21.0
188
849
ZX120
NOMESCO Finland
Intravenous
3.0
20.8
129
469
J45.9
ICD-10 Finland
Asthma, unspecified
2.3
20.7
214
1040
R03AC02
ATC
salbutamol; inhalant
1.8
20.3
552
3926
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
4.1
19.9
79
202
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.9
19.6
83
225
I50.9
ICD-10 Finland
Heart failure, unspecified
2.5
19.3
172
774
A46
ICD-10 Finland
Erysipelas
2.5
19.2
169
754
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
3.3
17.6
90
286
153
Kela drug reimbursment
Lenalidomid
15.9
17.5
28
18
4810A
ICD-9 Finland
Pneumococcal pneumonia[PNEUMONIA PNEUMOCOCCICA]
42.7
17.3
21
5
N17.9
ICD-10 Finland
Acute renal failure, unspecified
4.2
17.2
67
169
G00.9
ICD-10 Finland
Bacterial meningitis, unspecified
32.0
17.1
22
7
L04AX04
ATC
lenalidomide; oral
16.2
17.1
27
17
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.0
16.7
99
346
A41.8
ICD-10 Finland
Other specified sepsis
6.2
16.0
43
72
NJ3DA
NOMESCO Finland
Long bones of extremities X-ray examination
19.5
15.6
23
12
XF400
NOMESCO Finland
ECG with 12 standard connections
2.1
15.4
195
1027
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
4.6
15.4
53
119
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.1
15.2
196
1041
TK800
NOMESCO Finland
Hemodialysis
5.8
15.2
43
77
A02BC02
ATC
pantoprazole; systemic
1.7
15.1
619
4809
XW000
NOMESCO Finland
Bone marrow biopsy
3.6
15.1
68
196
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
2.9
15.0
93
338
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
3.5
14.9
71
214
R4110
NOMESCO Finland
Physiotherapy
1.9
14.8
283
1740
WW200
NOMESCO Finland
Immunization
4.6
14.7
51
115
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.9
14.5
89
321
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
14.4
302
1913
C07AB07
ATC
bisoprolol; oral
1.7
14.4
460
3314
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.7
14.1
102
407
J01DB01
ATC
cefalexin; oral
1.8
14.0
827
7054
TK810
NOMESCO Finland
Hemofiltration
13.8
13.8
23
17
H02AB07
ATC
prednisone; oral
2.2
13.7
153
764
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
4.3
13.6
50
120
I50.0
ICD-10 Finland
Congestive heart failure
2.7
13.3
96
381
L03AA02
ATC
filgrastim; parenteral
5.0
13.2
42
87
R05
ICPC
Cough
1.9
13.2
226
1330
R06.0
ICD-10 Finland
Dyspnoea
1.8
13.1
259
1603
J96.1
ICD-10 Finland
Chronic respiratory failure
5.0
12.9
41
85
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.6
12.8
429
3102
S97
ICPC
Chronic ulcer skin
3.1
12.5
71
242
EBA15
NOMESCO Finland
Extraction of large number of teeth
3.5
12.3
58
174
N05BA01
ATC
diazepam; systemic, rectal
2.1
12.3
147
753
J45.1
ICD-10 Finland
Nonallergic asthma
2.6
12.2
93
380
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
12.2
285
1855
ZX108
NOMESCO Finland
Inhalation
11.2
12.1
22
20
J01CE02
ATC
phenoxymethylpenicillin; oral
1.6
11.9
685
5646
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.8
11.9
77
288
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.0
11.6
148
777
GD1AD
NOMESCO Finland
Thorax CT examination
3.1
11.4
62
207
M04AA01
ATC
allopurinol; systemic
2.0
11.4
147
773
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
4.3
11.3
41
98
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
3.9
11.3
45
118
WX882
NOMESCO Finland
High dependency care
3.6
11.2
50
144
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.9
11.2
66
234
WX722
NOMESCO Finland
PEEP
3.0
11.1
63
215
J10.0
ICD-10 Finland
Influenza with pneumonia, seasonal influenza virus identified
7.5
11.0
25
34
J15.4
ICD-10 Finland
Pneumonia due to other streptococci
43.8
10.9
13
*
R02
ICPC
Shortness of breath/dyspnoea
2.1
10.8
128
652
A40.9
ICD-10 Finland
Streptococcal sepsis, unspecified
21.7
10.7
15
7
120
Kela drug reimbursment
Hypogammaglobulinaemia
21.7
10.7
15
7
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.9
10.7
171
978
R03DA04
ATC
theophylline; systemic, rectal
2.8
10.7
70
263
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
4.7
10.7
35
76
A03
ICPC
Fever
1.9
10.7
178
1035
N02AA05
ATC
oxycodone; systemic
2.0
10.7
151
826
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.4
10.6
51
156
N05CF01
ATC
zopiclone; oral
1.6
10.6
298
2029
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.3
10.6
98
447
SPAT1262
SPAT
Handing over of treatment supplies
1.8
10.6
192
1145
TKC20
NOMESCO Finland
Catheterisation of bladder
2.5
10.5
81
336
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.8
10.4
179
1053
WX725
NOMESCO Finland
Noninvasive ventilation
2.9
10.2
60
212
R96
ICPC
Asthma
2.3
10.2
92
412
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.2
10.2
109
531
127
Kela drug reimbursment
Transplant complication
5.5
10.2
29
54
R03BA05
ATC
fluticasone; inhalant
1.8
10.1
183
1089
B01AA03
ATC
warfarin; systemic
1.7
10.1
213
1336
L01AA01
ATC
cyclophosphamide; systemic
14.7
10.0
16
11
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.2
10.0
108
529
A04AA01
ATC
ondansetron; systemic, rectal
2.6
10.0
71
282
R03AK07
ATC
formoterol and budesonide; inhalant
1.8
10.0
177
1046
R95
ICPC
Chron obstructive pulmonary disease
4.0
10.0
39
101
L04AA06
ATC
mycophenolic acid; systemic
5.1
9.9
30
60
N02AX02
ATC
tramadol; systemic, rectal
1.6
9.9
395
2933
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
20.2
9.8
14
7
Z72.0
ICD-10 Finland
Tobacco use
4.3
9.7
35
84
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.7
9.7
232
1503
AA1AD
NOMESCO Finland
CT of head and brain
1.7
9.7
226
1456
6BA02
NOMESCO Finland
NA
13.5
9.7
16
12
J46
ICD-10 Finland
Status asthmaticus
3.9
9.7
39
104
AA1AA
NOMESCO Finland
Head X-ray examination
7.9
9.6
21
27
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.3
9.6
48
152
J01FA06
ATC
roxithromycin; oral
1.6
9.5
364
2666
X59
ICD-10 Finland
Exposure to unspecified factor
1.8
9.5
180
1089
N02BE01
ATC
paracetamol; systemic, rectal
1.6
9.4
828
7311
WW500
NOMESCO Finland
Blood transfusion
2.9
9.4
55
194
D65
ICD-10 Finland
Disseminated intravascular coagulation [defibrination syndrome]
30.3
9.4
12
*
SPAT1254
SPAT
Administration of medicine
1.8
9.4
171
1022
J96.0
ICD-10 Finland
Acute respiratory failure
5.6
9.4
26
47
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
8.1
9.4
20
25
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.2
9.3
92
433
C03DA01
ATC
spironolactone; oral
2.0
9.3
116
605
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.4
9.3
78
338
A07AA02
ATC
nystatin; oral
2.5
9.2
72
300
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.2
9.2
98
478
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
4.0
9.2
35
89
D64.9
ICD-10 Finland
Anaemia, unspecified
2.1
9.2
106
533
JN4BD
NOMESCO Finland
Extensive body CT
2.0
9.1
116
609
J20
ICD-10 Finland
Acute bronchitis
2.2
9.0
95
461
B01AB05
ATC
enoxaparin; parenteral
1.6
9.0
277
1917
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
2.4
9.0
74
318
H02AB09
ATC
hydrocortisone; systemic
3.6
9.0
39
111
SPAT1255
SPAT
Intravenous administration of medicine
2.4
9.0
76
330
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
4.0
9.0
34
86
J80
ICD-10 Finland
Adult respiratory distress syndrome
18.8
8.9
13
7
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
8.9
269
1854
B18.2
ICD-10 Finland
Chronic viral hepatitis C
6.0
8.8
23
39
H02AB04
ATC
methylprednisolone; systemic
1.9
8.8
142
816
R06AE07
ATC
cetirizine; oral
1.5
8.8
399
3030
A28
ICPC
Limited function/disability NOS
1.8
8.8
150
875
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.5
8.7
66
272
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.7
8.7
211
1370
ZX112
NOMESCO Finland
Subcutaneous
4.1
8.7
32
79
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.7
8.6
195
1241
R03AC12
ATC
salmeterol; inhalant
2.8
8.5
54
201
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.9
8.5
134
759
TDM10
NOMESCO Finland
Puncture of maxillary antrum
3.1
8.4
45
151
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
2.5
8.4
64
265
J01DA01
ATC
[U] cefalexin; systemic
1.5
8.4
585
4837
GBB00
NOMESCO Finland
Tracheostomy
5.1
8.4
25
50
N07BB01
ATC
disulfiram; oral
2.8
8.3
50
181
Z49.1
ICD-10 Finland
Extracorporeal dialysis
5.9
8.3
22
38
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
9.5
8.3
16
17
A06AD11
ATC
lactulose; oral
1.8
8.3
146
859
N17.8
ICD-10 Finland
Other acute renal failure
6.1
8.2
21
35
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
17.3
8.1
12
7
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
3.4
8.1
37
111
GAC97
NOMESCO Finland
Other endoscopic operation on pleura
22.2
8.0
11
5
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.5
8.0
282
2011
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
3.8
8.0
32
86
103
Kela drug reimbursment
Diabetes, insulin-treated
1.6
7.9
255
1781
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
7.9
169
1058
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.6
7.9
227
1540
N03AG01
ATC
valproic acid; systemic, rectal
2.3
7.8
67
296
R03DC03
ATC
montelukast; oral
1.8
7.8
142
847
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
3.1
7.8
41
137
SPAT1263
SPAT
Sampling
1.5
7.8
415
3238
L04AA01
ATC
[U] ciclosporin; systemic
4.6
7.7
25
55
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
3.7
7.7
32
89
V03AE01
ATC
polystyrene sulfonate; oral
5.6
7.7
21
38
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.4
7.6
62
265
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.3
7.6
71
327
J86.00
ICD-10 Finland
Empyema with broncho-pleural fistula
25.2
7.6
10
*
WW300
NOMESCO Finland
Transfer of autologic stem cells
10.1
7.5
14
14
J45
ICD-10 Finland
Asthma
2.0
7.5
90
461
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.5
7.5
307
2264
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.7
7.5
51
198
TPX10
NOMESCO Finland
Implantation of vascular injection port
3.5
7.4
33
97
B99
ICD-10 Finland
Other and unspecified infectious diseases
3.6
7.4
31
87
N18.0
ICD-10 Finland
End-stage renal disease
5.3
7.4
21
40
A02BC01
ATC
omeprazole; systemic
1.5
7.3
259
1843
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
3.6
7.3
31
88
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
7.3
398
3106
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.0
7.2
86
441
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.0
7.2
92
484
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.2
7.2
68
316
B34.9
ICD-10 Finland
Viral infection, unspecified
3.1
7.1
36
117
S76
ICPC
Skin infection other
2.6
7.1
50
200
L04AD01
ATC
ciclosporin; systemic
3.8
7.1
28
75
A40.0
ICD-10 Finland
Sepsis due to streptococcus, group A
12.1
7.1
12
10
N05AA02
ATC
levomepromazine; systemic
2.6
7.1
49
193
JN4AD
NOMESCO Finland
Body CT examination
2.1
7.0
80
400
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
4.3
6.9
24
57
WX730
NOMESCO Finland
Conventional respirator
3.8
6.9
27
72
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
2.4
6.9
57
246
WX704
NOMESCO Finland
Intubation
2.1
6.9
73
358
R11
ICD-10 Finland
Nausea and vomiting
2.0
6.9
81
412
A12AA04
ATC
calcium carbonate; oral
4.0
6.8
25
63
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.4
6.8
55
238
A10AE04
ATC
insulin glargine; parenteral
1.9
6.7
98
543
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
2.7
6.7
43
163
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.3
6.6
56
246
H02AB02
ATC
dexamethasone; systemic
1.9
6.6
92
501
N05CD07
ATC
temazepam; oral
1.8
6.6
118
698
R03BA01
ATC
beclometasone; inhalant
1.7
6.5
121
727
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
3.9
6.5
25
66
R03BA02
ATC
budesonide; inhalant
1.6
6.5
163
1067
A40.8
ICD-10 Finland
Other streptococcal sepsis
5.7
6.5
17
30
H66.0
ICD-10 Finland
Acute suppurative otitis media
2.0
6.4
84
445
J01FA09
ATC
clarithromycin; systemic
1.5
6.4
269
1980
L04AX01
ATC
azathioprine; systemic
2.5
6.3
45
181
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
6.6
6.3
15
23
F10.9
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Unspecified mental and behavioural disorder
5.6
6.3
17
31
N17.0
ICD-10 Finland
Acute renal failure with tubular necrosis
11.1
6.3
11
10
B03XA02
ATC
darbepoetin alfa; parenteral
3.7
6.3
25
68
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
9.3
6.3
12
13
GAC46
NOMESCO Finland
Partial decortication of pleura
18.1
6.3
9
5
N05AH03
ATC
olanzapine; systemic
2.2
6.3
57
262
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
6.3
380
3008
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
6.3
6
*
WX110
NOMESCO Finland
Local anesthesy
1.4
6.2
647
5614
M10.9
ICD-10 Finland
Gout, unspecified
2.1
6.2
68
336
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
3.8
6.2
24
64
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
6.3
6.2
15
24
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.0
6.2
80
424
N06AX11
ATC
mirtazapine; oral
1.5
6.1
262
1936
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
4.7
6.1
19
41
R03AC13
ATC
formoterol; inhalant
2.4
6.1
50
218
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
3.8
6.1
24
65
J01AA02
ATC
doxycycline; systemic
1.4
6.1
696
6128
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
3.5
6.0
26
76
329
Kela drug reimbursment
Lenalidomide
10.1
6.0
11
11
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
405
1615
3.26
76.07
2.5
1.9
—
—
—
0
0
242
745
3.81
67.53
5.1
2.7
12.3
10.7
g/l
2.68
220
683
299
1137
3.16
59.12
2.3
1.8
—
—
—
0
0
297
1131
3.15
58.52
2.3
1.8
—
—
—
0
0
262
1083
2.81
43.33
9.2
8.7
10.2
12.3
kpa
12.36
240
1035
262
1083
2.81
43.33
9.2
8.7
5.1
5.1
kpa
0.16
240
1032
258
1078
2.77
41.66
9.3
8.8
1.8
1.2
mmol/l
1.08
204
838
260
1106
2.72
40.44
4.3
4.1
244.7
256.6
u/l
0.43
247
1039
292
1343
2.54
38.57
9.4
6.8
1.1
1.1
mmol/l
1.19
272
1239
95
219
4.62
38.49
1.5
1.3
—
—
—
0
0
95
219
4.62
38.49
1.5
1.3
—
—
—
0
0
118
326
3.90
37.63
3.0
2.9
—
—
—
0
0
50
65
7.98
36.34
2.4
2.8
9.0
11.5
%
0.61
23
37
79
173
4.81
34.03
1.8
1.6
—
—
—
0
0
189
763
2.75
32.06
5.7
2.8
67.9
66.1
g/l
1.36
165
688
45
60
7.75
31.99
2.4
3.0
—
—
—
0
0
211
904
2.61
31.79
11.6
8.5
11.3
9.7
mmol/l
2.19
201
861
705
4904
2.04
31.67
8.8
6.4
10.8
11.9
umol/l
1.28
679
4636
94
252
3.96
31.18
2.1
1.7
—
—
—
0
0
774
5594
2.05
30.92
14.7
9.1
4.7
4.1
e9/l
6.58
681
4870
300
1535
2.27
30.37
4.7
4.1
0.8
0.8
mmol/l
1.20
279
1435
65
133
5.11
30.29
1.8
1.6
—
—
—
0
0
91
244
3.95
30.17
2.1
1.7
—
—
—
0
0
267
1311
2.33
29.73
3.2
2.7
19.3
23.3
%
5.24
228
1128
69
151
4.78
29.72
1.9
1.5
—
—
—
0
0
123
408
3.24
29.55
2.2
1.9
3.4
2.0
ug/l
0.73
110
358
64
135
4.95
28.79
1.8
1.6
—
—
—
0
0
216
981
2.46
28.58
6.3
5.1
1.7
1.9
mmol/l
0.19
184
772
217
992
2.44
28.29
6.3
5.1
5.9
5.9
kpa
0.51
211
959
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
107
336
3.39
28.05
3.2
3.4
0.3
0.4
u/ml
2.45
65
193
274
1398
2.24
27.65
3.2
2.6
2.2
2.3
g/l
2.22
256
1291
233
1133
2.31
26.26
3.8
2.9
1.9
1.8
%
1.39
203
1019
620
4307
1.89
25.95
11.3
6.7
1.2
1.2
mmol/l
1.93
577
3899
43
70
6.33
25.48
2.7
2.7
702.5
611.9
e6/l
0.22
32
55
42
67
6.46
25.38
2.7
2.9
0.2
0.2
e9/l
0.27
32
55
587
4030
1.88
25.26
8.2
5.3
32.9
35.5
g/l
16.43
545
3749
193
885
2.40
24.79
10.7
9.6
116.9
121.7
g/l
2.45
182
850
282
1519
2.11
24.49
3.2
2.6
10.6
13.3
umol/l
8.90
262
1403
92
286
3.40
24.47
7.1
3.4
96.1
33.4
mg/l
0.87
72
236
130
496
2.81
24.32
9.8
11.5
24.6
24.5
mmol/l
0.15
119
465
657
4717
1.85
24.13
13.2
7.4
1.2
1.2
mmol/l
1.98
561
3997
91
285
3.37
23.92
7.2
3.4
72.2
77.8
mg/l
0.09
72
232
187
863
2.38
23.61
8.4
8.6
1.7
1.4
mmol/l
0.79
177
821
121
453
2.86
23.43
2.1
2.0
1.6
1.5
g/l
0.61
103
394
161
698
2.51
23.30
2.0
1.7
—
—
—
0
0
60
149
4.18
22.04
3.1
3.5
2.1
1.1
%
0.57
53
125
744
5668
1.80
21.34
8.7
5.2
6.9
6.7
mmol/l
1.62
703
5274
126
507
2.66
21.20
12.5
12.5
—
—
—
0
0
96
335
3.03
21.06
5.6
2.7
—
—
—
0
0
96
335
3.03
21.06
5.6
2.7
7.5
7.4
g/l
0.22
64
253
96
335
3.03
21.06
5.6
2.7
4.2
3.7
g/l
0.88
59
245
92
315
3.08
20.86
5.4
2.7
3.1
3.2
g/l
0.28
59
248
88
294
3.15
20.80
5.1
2.9
4.2
1.0
g/l
2.27
68
255
49
111
4.56
20.24
1.3
1.3
1603.4
1615.7
e6/l
0.01
33
78
137
591
2.48
19.94
2.0
1.6
—
—
—
0
0
69
206
3.49
19.53
6.6
7.0
571.1
365.6
iu/ml
0.22
15
34
389
2522
1.80
18.75
2.7
2.2
3.2
3.0
mg/l
0.79
336
2147
51
127
4.15
18.68
1.3
1.4
34.4
31.1
g/l
0.87
40
112
457
3110
1.75
18.60
4.4
3.4
51.0
33.4
u/l
0.64
427
2950
81
278
3.05
18.28
1.6
1.6
—
—
—
0
0
129
564
2.44
18.20
1.5
1.5
—
—
—
0
0
87
312
2.93
18.17
5.2
2.7
14.2
10.3
g/l
2.17
63
266
128
560
2.44
18.03
5.3
6.1
24.2
23.9
mmol/l
0.46
121
517
411
2740
1.75
17.82
3.9
3.3
0.7
0.5
e6/l
0.96
319
2076
133
598
2.37
17.63
10.4
7.8
24.8
24.5
mmol/l
0.27
119
553
297
1803
1.86
17.58
5.0
3.8
288.7
377.0
ng/l
0.36
243
1399
61
181
3.50
17.43
2.1
1.8
—
—
—
0
0
64
199
3.34
17.01
1.5
1.5
—
—
—
0
0
150
722
2.23
16.93
6.8
4.5
2.1
1.7
mmol/l
0.63
113
525
99
403
2.59
16.22
6.7
5.9
1.8
1.6
%
1.26
89
377
168
861
2.10
16.15
4.8
4.4
4.7
4.6
kpa
0.13
162
832
176
923
2.06
15.90
3.1
2.6
0.2
0.2
g/l
1.94
156
859
41
98
4.29
15.85
1.3
1.3
131633.6
107180.9
e6/l
0.11
24
58
871
7226
1.72
15.82
12.0
7.4
90.3
80.2
u/l
4.44
831
6784
52
150
3.58
15.52
2.1
1.7
—
—
—
0
0
41
101
4.17
15.25
2.1
1.8
—
—
—
0
0
786
6380
1.65
15.16
5.9
4.4
61.0
2106.7
e6/l
—
7
108
44
115
3.93
15.12
2.1
1.7
—
—
—
0
0
150
759
2.11
14.87
6.9
4.5
5.1
5.2
kpa
0.53
140
709
153
789
2.07
14.41
4.7
3.0
309.6
220.8
ng/l
1.23
139
724
282
1778
1.76
14.38
2.1
1.8
1180.5
1162.0
nmol/l
0.10
218
1351
31
64
4.94
14.31
2.7
3.0
43.8
38.8
%
0.38
11
16
73
276
2.75
13.84
4.3
2.7
37.0
37.5
g/l
0.29
57
236
302
1974
1.70
13.43
2.1
1.5
2.4
2.4
g/l
0.01
209
1182
47
140
3.45
13.38
6.7
6.2
11.3
11.4
mg/l
0.07
42
125
29
60
4.93
13.36
2.3
1.7
—
—
—
0
0
411
2914
1.62
13.29
3.2
2.6
53.6
57.9
u/l
1.65
390
2686
245
1520
1.77
13.09
2.2
2.4
30.5
29.8
s
1.07
239
1475
75
297
2.63
13.00
3.4
1.4
0.2
0.2
g/l
0.06
69
284
205
1212
1.83
12.85
9.7
7.9
103.5
104.3
mmol/l
1.28
199
1184
17
21
8.20
12.77
2.4
2.2
—
—
—
0
0
32
76
4.30
12.50
2.5
2.3
704.5
772.9
e6/l
0.16
14
29
26
52
5.09
12.45
2.5
1.8
—
—
—
0
0
58
207
2.89
12.25
1.4
1.5
—
—
—
0
0
67
260
2.67
12.10
4.9
2.8
0.2
0.0
g/l
0.41
60
238
25
51
4.98
11.71
2.5
1.8
—
—
—
0
0
382
2731
1.58
11.62
3.9
3.2
2645.1
1601.2
ng/l
2.64
321
2338
88
397
2.31
11.54
2.7
1.9
—
—
—
0
0
251
1619
1.69
11.53
3.3
3.1
3.6
1.9
e6/l
1.22
138
902
63
243
2.68
11.52
4.7
2.9
0.0
0.0
g/l
0.00
56
223
25
52
4.89
11.46
3.3
2.8
—
—
—
0
0
63
245
2.66
11.34
4.7
2.9
0.0
0.0
g/l
0.49
56
223
36
101
3.64
11.24
3.8
4.0
—
—
—
0
0
542
4211
1.52
11.19
3.9
2.9
191.8
131.8
ug/l
2.43
499
3874
40
121
3.38
11.15
2.1
1.8
—
—
—
0
0
12
11
11.01
11.07
1.2
1.1
—
—
—
0
0
256
1680
1.66
10.96
3.3
2.9
2.2
1.0
e6/l
1.86
146
964
187
1126
1.78
10.94
3.9
3.2
8.5
8.9
umol/l
0.08
156
978
62
245
2.61
10.82
1.4
1.5
—
—
—
0
0
20
36
5.63
10.72
4.4
5.1
—
—
—
0
0
34
95
3.65
10.68
1.3
1.4
6.0
6.4
mmol/l
0.31
29
90
302
2084
1.60
10.52
3.4
2.6
7.6
5.4
e6/l
1.32
268
1844
33
93
3.62
10.25
1.2
1.4
—
—
—
0
0
1059
9628
1.76
10.08
30.9
14.4
39.0
24.8
mg/l
19.35
946
7600
112
590
1.99
9.90
1.6
1.3
155.5
254.3
u/ml
1.03
102
536
164
983
1.77
9.70
4.3
3.3
—
—
—
0
0
28
74
3.85
9.53
4.2
2.3
—
—
—
0
0
48
178
2.77
9.50
4.2
3.7
57.7
57.2
%
0.07
48
178
77
361
2.21
9.25
2.5
1.8
—
—
—
0
0
69
309
2.31
9.24
2.2
3.9
3.9
3.6
g/l
0.56
64
294
54
219
2.53
8.98
3.4
2.3
124.1
130.6
g/l
1.14
42
167
65
288
2.33
8.92
1.5
1.2
—
—
—
0
0
28
79
3.60
8.71
2.4
1.7
—
—
—
0
0
18
37
4.92
8.37
1.2
1.6
—
—
—
0
0
53
222
2.45
8.25
1.6
1.8
40189.8
16195.1
e6/l
0.99
41
161
28
82
3.47
8.25
1.5
1.8
—
—
—
0
0
29
88
3.35
8.10
2.1
1.6
—
—
—
0
0
29
88
3.35
8.10
2.1
1.6
—
—
—
0
0
29
88
3.35
8.10
2.1
1.6
—
—
—
0
0
50
206
2.49
8.07
4.1
2.6
15.3
16.3
%
1.06
31
113
23
60
3.89
7.99
1.5
1.5
—
—
—
0
0
42
161
2.67
7.84
1.1
1.1
—
—
—
0
0
801
6981
1.43
7.83
5.9
4.0
21.0
12.0
mm/h
21.99
741
6407
408
3169
1.43
7.65
4.6
3.4
2.3
2.3
mmol/l
2.04
360
2765
451
3571
1.42
7.58
5.3
3.7
45.3
56.2
ng/l
0.37
335
2486
124
741
1.75
7.39
6.2
4.6
108.6
85.4
ng/l
1.22
109
654
387
2997
1.43
7.31
4.2
3.3
6.5
7.9
mmol/l
8.06
322
2516
325
2444
1.45
7.18
4.7
2.9
375.5
7475.1
umol/l
9.67
291
2111
29
96
3.07
7.07
3.3
3.1
57.2
55.2
%
0.14
23
72
181
1208
1.59
7.05
2.4
1.8
1.6
1.5
%
0.95
151
1052
473
3815
1.39
7.00
2.3
2.0
93.3
94.0
pmol/l
0.14
284
2017
48
210
2.34
6.84
1.5
1.6
107.9
107.8
u/ml
—
9
36
59
282
2.15
6.81
3.6
1.9
—
—
—
0
0
42
174
2.46
6.74
4.2
3.3
4.7
4.2
e9/l
0.48
42
174
298
2231
1.44
6.68
1.8
1.5
19.7
19.8
nmol/l
0.03
261
1897
359
2780
1.41
6.67
2.5
2.1
269.9
266.4
u/l
0.01
328
2617
25
79
3.21
6.59
1.8
1.5
1.4
1.3
promille
0.17
20
66
361
2808
1.41
6.52
5.0
4.1
28.1
9.4
mg/mmol
2.04
250
1832
539
4481
1.36
6.46
5.9
4.2
—
—
—
0
0
716
6228
1.36
6.39
4.5
3.2
76.1
48.1
u/l
5.08
668
5805
464
3775
1.37
6.35
2.8
2.3
75.0
75.5
nmol/l
0.13
420
3369
894
8070
1.40
6.28
33.6
17.6
14.1
13.6
%
17.10
871
7907
36
144
2.55
6.23
1.3
1.3
—
—
—
0
0
14
30
4.71
6.22
3.1
2.0
—
—
—
0
0
32
121
2.69
6.19
2.4
1.8
89.3
89.9
%
0.18
32
121
139
900
1.61
6.13
2.8
2.1
342.8
368.8
nmol/l
0.60
125
826
16
39
4.14
6.10
2.8
1.8
—
—
—
0
0
279
2095
1.43
6.09
1.9
1.9
1.8
1.2
mg/l
1.27
224
1594
180
1241
1.53
6.04
24.4
25.5
1.3
1.3
inr
0.01
15
171
18
50
3.64
5.77
2.3
1.7
—
—
—
0
0
18
50
3.64
5.77
2.3
1.7
—
—
—
0
0
18
50
3.64
5.77
2.3
1.7
—
—
—
0
0
18
50
3.64
5.77
2.3
1.7
—
—
—
0
0
25
87
2.91
5.64
1.4
1.1
—
—
—
0
0
15
38
3.98
5.45
2.5
1.8
—
—
—
0
0
15
38
3.98
5.45
2.5
1.8
—
—
—
0
0
17
48
3.58
5.33
1.6
1.2
—
—
—
0
0
39
175
2.27
5.30
1.4
1.2
1.1
7.7
u/ml
—
8
14
61
326
1.92
5.26
1.3
1.4
—
—
—
0
0
135
902
1.56
5.22
3.0
2.4
34.5
86.5
u/l
0.48
108
764
28
109
2.61
5.16
1.5
1.7
67.8
60.1
%
0.48
19
76
49
249
2.01
4.89
3.0
2.1
11.0
11.8
mg/l
0.26
44
226
47
237
2.02
4.80
1.4
1.2
31.4
16.3
u/ml
—
8
10
45
224
2.05
4.76
1.4
1.2
1.5
2.6
u/ml
—
8
21
45
226
2.03
4.65
1.4
1.2
10.1
11.0
u/ml
0.04
15
31
114
754
1.56
4.62
5.5
3.8
1.2
1.2
mmol/l
0.01
102
646
48
249
1.97
4.54
1.7
1.7
—
—
—
0
0
67
388
1.77
4.52
2.4
2.4
9142.1
4034.8
u/l
0.44
27
164
254
1967
1.37
4.51
2.0
1.7
53398505.4
15985782.9
pmol/l
0.31
206
1639
954
8863
1.35
4.46
30.6
15.5
38.1
40.0
%
7.72
638
6400
15
47
3.22
4.06
1.1
1.3
—
—
—
0
0
26
111
2.37
4.01
1.7
1.3
—
—
—
0
0
54
305
1.81
3.99
8.4
8.1
1.5
1.5
mg/l
0.01
49
284
25
106
2.39
3.92
5.6
2.7
—
—
—
0
0
8
11
7.31
3.86
1.3
1.5
—
—
—
0
0
15
49
3.09
3.81
1.0
1.0
—
—
—
0
0
7
9
7.81
3.56
8.3
7.0
—
—
—
0
0
27
126
2.17
3.43
3.6
7.4
6.9
6.7
mmol/l
0.14
27
102
15
53
2.85
3.36
5.2
7.3
33.0
65.3
u/ml
—
5
16
10
27
3.73
3.36
1.3
1.6
—
—
—
0
0
63
393
1.64
3.31
2.2
2.1
37.6
38.8
u/l
0.17
56
351
284
2330
1.29
3.30
3.5
2.4
—
—
—
0
0
532
4695
1.24
3.28
4.8
3.5
0.0
0.0
estimate
0.00
122
908
19
78
2.46
3.22
1.4
1.4
24.4
28.9
%
0.22
14
54
35
185
1.92
3.22
1.7
1.5
—
—
—
0
0
11
33
3.35
3.19
1.1
1.1
—
—
—
0
0
530
4686
1.23
3.19
6.4
4.9
0.0
0.0
estimate
0.50
125
924
535
4740
1.23
3.14
4.7
3.6
0.0
0.0
estimate
0.80
118
890
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
16
61
2.64
3.14
1.3
1.1
—
—
—
0
0
113
813
1.43
3.10
2.9
2.5
5.9
7.2
ug/l
0.64
92
715
37
202
1.86
3.10
2.4
3.1
0.8
0.9
nmol/l
0.73
28
159
1024
9765
1.30
2.91
33.6
16.8
138.8
139.6
mmol/l
17.25
1000
9483
53
331
1.63
2.81
1.5
1.2
0.5
1.6
u/ml
—
5
18
1025
9787
1.30
2.80
33.7
16.9
4.0
4.0
mmol/l
0.58
997
9489
42
247
1.73
2.79
1.2
1.3
—
—
—
0
0
8
19
4.23
2.68
2.4
3.5
14.4
15.7
ml/dl
—
8
14
14
55
2.56
2.62
1.2
1.1
—
—
—
0
0
20
93
2.17
2.61
1.5
1.2
108.6
57.1
u/l
0.40
15
64
13
50
2.62
2.53
1.6
1.2
25.7
18.7
u/l
0.58
13
44
17
75
2.28
2.51
1.8
2.3
647.3
628.2
ml
—
8
49
36
210
1.74
2.48
1.9
1.7
—
—
—
0
0
9
26
3.48
2.48
1.2
1.0
—
—
—
0
0
47
297
1.61
2.42
1.6
1.5
0.1
0.1
iu/ml
0.04
11
57
52
780
0.65
2.40
1.5
1.6
—
—
—
0
0
15
64
2.36
2.39
18.5
19.6
1477.4
1414.2
nmol/l
0.14
15
64
24
125
1.94
2.36
1.1
1.1
—
—
—
0
0
13
52
2.52
2.36
1.2
1.2
—
—
—
0
0
56
373
1.53
2.31
3.1
3.5
112.3
3933.5
u/ml
0.80
42
318
13
53
2.47
2.28
1.6
1.2
102.5
78.1
u/l
0.29
13
48
39
239
1.65
2.28
1.2
1.4
231.7
252.8
u/ml
0.22
19
130
28
156
1.81
2.27
3.7
2.9
160.7
32.1
u/ml
0.59
28
147
80
575
1.42
2.27
1.8
1.9
—
—
—
0
0
11
42
2.63
2.19
1.1
1.1
384.9
193.5
iu/ml
0.34
11
42
43
274
1.59
2.17
1.4
1.5
315.8
286.2
ug/g
0.31
20
163
8
25
3.21
2.09
1.3
1.1
—
—
—
0
0
865
9079
0.84
2.08
4.4
4.2
1.4
1.4
mmol/l
1.92
802
8331
7
20
3.51
2.05
1.1
1.2
—
—
—
0
0
15
69
2.19
2.05
2.0
1.3
3.0
0.8
u/ml
—
5
35
43
279
1.56
2.02
1.3
1.2
—
—
—
0
0
30
179
1.69
1.96
1.4
1.2
71.2
29.0
u/ml
—
5
12
677
6299
1.17
1.96
3.6
3.1
—
—
—
0
0
8
27
2.98
1.93
1.3
1.1
—
—
—
0
0
8
28
2.87
1.86
1.3
1.1
—
—
—
0
0
11
46
2.40
1.85
1.7
1.3
—
—
—
0
0
11
46
2.40
1.85
1.7
1.3
—
—
—
0
0
33
206
1.62
1.84
1.8
1.4
—
—
—
0
0
10
41
2.45
1.75
1.1
1.2
—
—
—
0
0
877
9151
0.85
1.74
4.5
4.3
4.5
4.6
mmol/l
1.39
821
8446
5
13
3.86
1.71
1.8
2.0
7.0
4.0
nmol/l
—
5
8
42
283
1.50
1.71
1.3
1.1
—
—
—
0
0
6
19
3.17
1.66
1.0
1.0
—
—
—
0
0
5
14
3.58
1.61
1.0
4.6
—
—
—
0
0
12
56
2.15
1.61
1.3
1.1
1.1
1.1
ratio
—
5
20
90
704
1.30
1.56
1.9
2.0
—
—
—
0
0
21
122
1.73
1.55
2.0
1.5
—
—
—
0
0
21
122
1.73
1.55
2.0
1.5
—
—
—
0
0
838
8747
0.87
1.54
4.1
3.8
1.4
1.3
mmol/l
2.49
773
7992
8
33
2.43
1.54
4.1
3.0
—
—
—
0
0
8
33
2.43
1.54
1.1
1.0
1176.8
1351.2
miu/ml
—
8
33
8
33
2.43
1.54
4.1
3.0
—
—
—
0
0
22
130
1.71
1.53
1.3
1.1
—
—
—
0
0
5
15
3.34
1.52
1.0
1.1
—
—
—
0
0
21
123
1.72
1.51
2.0
1.5
—
—
—
0
0
6
21
2.87
1.50
1.0
1.0
—
—
—
0
0
12
58
2.08
1.49
1.8
1.4
—
—
—
0
0
12
58
2.08
1.49
1.8
1.4
—
—
—
0
0
36
243
1.50
1.48
1.8
1.6
—
—
—
0
0
21
124
1.71
1.47
2.0
1.5
—
—
—
0
0
21
124
1.71
1.47
2.0
1.5
—
—
—
0
0
202
1742
1.19
1.46
3.7
3.1
2.5
2.4
mmol/l
1.90
165
1521
22
353
0.62
1.46
1.1
1.8
4.5
3.0
mg/l
0.43
16
257
178
2074
0.83
1.46
2.5
3.1
0.7
0.8
ug/l
0.79
118
1381
13
66
1.98
1.43
1.8
2.0
—
—
—
0
0
13
66
1.98
1.43
1.8
2.0
—
—
—
0
0
6
22
2.74
1.43
1.0
1.2
—
—
—
0
0
116
949
1.25
1.42
3.5
4.2
17.3
27.0
ug/l
0.34
95
794
16
88
1.83
1.42
1.3
1.0
—
—
—
0
0
28
181
1.56
1.41
3.7
3.6
124.5
659.1
u/ml
0.66
28
169
397
3619
1.14
1.40
5.5
3.7
—
—
—
0
0
89
1105
0.79
1.35
17.4
7.3
—
—
—
0
0
33
224
1.49
1.34
1.5
1.7
3.5
3.8
mmol/l
0.44
28
207
22
136
1.63
1.33
1.4
1.2
4.8
2.1
u/ml
—
6
44
11
54
2.05
1.33
1.2
1.3
—
47.1
—
0
7
13
233
0.55
1.33
2.0
1.4
—
—
—
0
0
33
225
1.48
1.32
1.5
1.8
424.4
44.5
e6/l
1.02
27
177
33
225
1.48
1.32
1.5
1.8
1852.6
657.8
e6/l
0.41
27
182
5
18
2.78
1.28
1.0
1.2
—
—
—
0
0
20
122
1.65
1.28
2.1
1.5
—
—
—
0
0
900
9307
0.87
1.27
5.0
4.7
2.6
2.7
mmol/l
2.34
828
8530
16
92
1.75
1.25
1.1
1.4
—
—
—
0
0
6
25
2.41
1.24
1.2
1.1
—
—
—
0
0
14
78
1.80
1.21
1.3
2.4
1.5
2.0
u/field
—
6
30
870
9004
0.88
1.19
4.9
4.4
6.1
5.9
mmol/l
2.43
784
8149
66
518
1.29
1.17
1.4
1.3
—
—
—
0
0
11
57
1.94
1.17
2.6
2.1
—
—
—
0
0
7
31
2.27
1.10
1.0
1.1
—
—
—
0
0
209
1853
1.15
1.10
1.5
1.6
—
—
—
0
0
18
280
0.64
1.10
1.3
1.5
—
—
—
0
0
261
2886
0.88
1.09
3.6
4.4
22.6
21.2
%
0.67
118
1398
7
32
2.19
1.08
1.1
1.4
—
—
—
0
0
16
254
0.62
1.07
1.4
1.4
—
—
—
0
0
16
254
0.62
1.07
1.4
1.4
—
—
—
0
0
16
253
0.63
1.05
1.4
1.4
—
—
—
0
0
11
61
1.81
0.98
1.2
1.3
—
—
—
0
0
5
23
2.18
0.98
2.8
2.0
19.7
15.8
umol/l
—
5
23
5
23
2.18
0.98
8.6
6.3
—
—
—
0
0
49
624
0.78
0.97
1.2
1.2
189.6
134.8
iu/ml
0.28
16
240
819
8466
0.90
0.96
7.2
5.7
41.6
39.9
mmol/mol
4.38
755
7812
280
2558
1.12
0.94
5.6
3.8
0.0
0.0
estimate
0.08
114
888
12
70
1.72
0.92
1.0
1.0
—
—
—
0
0
20
134
1.50
0.92
1.4
1.2
7.0
5.0
u/ml
—
10
56
6
28
2.15
0.91
1.2
1.1
—
—
—
0
0
29
211
1.38
0.89
1.2
1.3
—
—
—
0
0
17
253
0.67
0.88
1.4
1.4
—
—
—
0
0
10
56
1.79
0.88
2.3
2.5
—
—
—
0
0
40
514
0.77
0.86
1.0
1.0
—
—
—
0
0
8
44
1.82
0.86
1.3
1.2
148.4
568.9
u/l
—
8
38
166
1477
1.14
0.86
1.3
1.3
51.3
32.9
iu/ml
0.70
58
449
14
88
1.60
0.84
1.4
1.4
—
—
—
0
0
6
31
1.94
0.84
1.0
1.3
13.5
9.0
ug/l
—
6
31
10
57
1.76
0.83
1.3
1.2
—
—
—
0
0
21
146
1.45
0.82
3.0
3.2
6.3
9.9
umol/l
0.76
15
112
40
311
1.30
0.81
1.2
1.3
193.3
246.9
miu/ml
0.36
14
149
14
89
1.58
0.81
1.1
1.0
—
—
—
0
0
11
66
1.67
0.78
1.1
1.1
—
—
—
0
0
11
66
1.67
0.78
1.1
1.1
—
—
—
0
0
11
66
1.67
0.78
1.1
1.1
—
—
—
0
0
11
66
1.67
0.78
1.1
1.1
—
—
—
0
0
6
34
1.77
0.76
2.3
2.4
91.3
106.6
ug/l
—
6
34
99
1139
0.86
0.75
4.9
4.3
33.3
31.7
%
0.69
79
761
11
67
1.65
0.75
1.1
1.1
—
—
—
0
0
34
263
1.30
0.73
1.2
1.1
—
—
—
0
0
7
38
1.85
0.73
1.1
1.0
—
—
—
0
0
14
92
1.53
0.72
1.6
1.4
11.9
10.9
mmol/l
—
7
21
43
345
1.26
0.71
1.9
1.5
275.7
313.8
mu/l
0.55
34
313
31
239
1.30
0.69
2.7
2.4
185.1
84.0
ug/min
0.71
20
141
61
513
1.20
0.66
3.3
3.3
4.6
4.6
pmol/l
0.01
56
455
8
51
1.57
0.60
1.5
1.6
—
—
—
0
0
236
2194
1.09
0.59
1.3
1.3
4.7
1.5
u/ml
0.69
43
551
20
149
1.35
0.58
1.3
1.3
—
—
—
0
0
6
36
1.67
0.56
1.5
1.6
1.5
6.7
nmol/l
—
6
28
880
8613
1.08
0.56
4.7
4.5
2.0
2.1
mu/l
0.32
800
7837
6
37
1.62
0.55
7.7
2.1
242.5
204.6
u/l
—
6
37
156
1429
1.11
0.54
1.2
1.2
27.4
12.0
u/ml
0.65
37
541
6
39
1.54
0.53
1.0
1.1
93.8
99.2
%
—
6
33
16
213
0.75
0.50
1.7
1.8
5.5
5.7
iu/l
—
5
62
39
325
1.21
0.50
1.6
1.6
11.1
7.9
u/l
0.91
32
260
24
190
1.27
0.48
2.0
1.7
—
—
—
0
0
729
7120
1.06
0.44
3.9
3.7
14.7
14.8
pmol/l
0.61
651
6421
10
69
1.45
0.44
3.5
1.7
—
—
—
0
0
7
51
1.37
0.44
1.1
1.1
21.7
30.5
u/l
—
7
37
7
51
1.37
0.44
1.1
1.1
79.9
87.8
u/l
—
7
38
26
211
1.24
0.43
4.0
3.8
51.6
25.9
mg/l
1.63
20
140
77
857
0.89
0.42
2.6
2.1
11.6
12.8
nmol/l
0.67
65
753
1023
10105
1.08
0.41
16.4
10.1
28.0
26.6
u/l
0.97
987
9733
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
8
59
1.36
0.41
2.1
1.5
1.0
1.0
g/l
—
8
59
0
19
0.00
0.39
0.0
1.0
—
0.8
—
0
14
5
36
1.39
0.38
1.8
1.1
—
—
—
0
0
16
203
0.79
0.38
1.3
1.1
5.4
2.5
u/ml
—
10
96
885
8716
1.06
0.36
23.9
13.2
82.7
82.1
ml/min/173m2
0.28
779
7090
56
499
1.13
0.35
1.7
1.5
—
—
—
0
0
346
3590
0.95
0.34
4.7
5.1
2.3
2.7
ug/l
0.48
301
3192
16
128
1.25
0.32
1.2
1.5
0.2
0.3
nmol/l
0.55
11
105
202
2121
0.94
0.31
6.1
3.7
1.0
1.0
kg/l
0.10
33
298
7
54
1.30
0.30
3.6
1.9
—
—
—
0
0
1083
10746
1.07
0.30
40.9
20.9
7.8
6.8
e9/l
14.42
1055
10428
10
129
0.77
0.28
1.4
1.6
—
—
—
0
0
33
371
0.89
0.24
3.6
2.6
29.2
53.2
u/ml
1.04
33
353
26
228
1.14
0.23
2.2
1.4
—
—
—
0
0
138
1316
1.05
0.22
2.1
2.2
—
—
—
0
0
30
267
1.13
0.21
1.8
1.7
—
—
—
0
0
30
267
1.13
0.21
1.3
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
91.1
—
0
11
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
1080
10735
1.05
0.21
41.1
20.9
252.7
247.1
e9/l
1.52
1056
10443
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
2.5
—
68.1
—
0
13
6
50
1.20
0.19
1.7
1.4
5.8
6.2
mmol/l
—
6
50
1080
10743
1.05
0.18
40.9
20.9
4.3
4.5
e12/l
27.34
1052
10423
17
147
1.16
0.18
1.1
1.1
—
—
—
0
0
7
62
1.13
0.17
3.4
1.3
—
—
—
0
0
7
63
1.11
0.17
3.4
1.3
—
—
—
0
0
1080
10747
1.04
0.16
41.3
21.0
128.8
135.8
g/l
34.39
1061
10573
30
328
0.91
0.15
1.6
1.5
—
—
—
0
0
6
80
0.75
0.15
1.3
1.7
—
—
—
0
0
13
112
1.16
0.14
1.2
1.0
—
—
—
0
0
125
1208
1.04
0.13
2.1
2.1
—
—
—
0
0
37
346
1.07
0.12
1.6
1.5
22.2
19.6
iu/l
0.23
30
284
28
301
0.93
0.11
2.7
1.7
—
—
—
0
0
35
372
0.94
0.10
3.5
1.8
—
—
—
0
0
18
164
1.10
0.09
1.1
1.1
—
10.8
—
0
8
5
46
1.09
0.09
1.2
1.1
—
—
—
0
0
5
47
1.06
0.09
1.2
2.3
—
—
—
0
0
20
215
0.93
0.07
2.4
1.7
168.8
220.5
pmol/l
1.64
20
204
242
2450
0.98
0.06
1.7
1.7
1.4
1.4
mmol/l
0.51
209
2068
12
131
0.92
0.05
1.1
1.1
—
—
—
0
0
121
1195
1.01
0.03
1.5
1.4
—
—
—
0
0
74
730
1.01
0.02
3.4
2.8
50.8
66.2
ml/min/173m2
2.54
32
292
13
134
0.97
0.00
1.1
1.1
10.5
2.2
u/ml
—
5
57
7
73
0.96
0.00
1.1
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
8
82
0.98
0.00
2.3
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
5.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
56
0.89
0.00
1.2
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
54.6
—
0
8
Mortality – FinRegistry
↥Association
Association between endpoint PNEUMO_SEPTHICHE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| PNEUMO_SEPTHICHE | 2.811 [2.33, 3.39] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.068 |
During the follow-up period (1.1.1998 — 31.12.2019), 996 out of 4840 females with PNEUMO_SEPTHICHE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| PNEUMO_SEPTHICHE | 3.457 [2.88, 4.14] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1385 out of 5934 males with PNEUMO_SEPTHICHE died.
Mortality risk
Mortality risk for people of age
years, who have PNEUMO_SEPTHICHE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.271% | 0.64% |
| 5 | 1.424% | 3.663% |
| 10 | 3.592% | 8.811% |
| 15 | 7.108% | 16.967% |
| 20 | 12.402% | 26.779% |
Relationships between endpoints
↥Index endpoint: PNEUMO_SEPTHICHE – Pneumococcal septicemia
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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