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Atrial septal defect

EFO Endpoint Browser PheWeb

Q17_ASD

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — Q21.1
  • Hospital discharge: ICD-9 — 7455A|7456A
  • Hospital discharge: excluded ICD-10 — Q20|Q2111|Q2[2-5]|Q26[0-1]|Q26[5-9]
  • Cause of death: ICD-10 — Q21.1
  • Cause of death: ICD-9 — 7455A|7456A
  • Cause of death: excluded ICD-10 — Q20|Q2111|Q2[2-5]|Q26[0-1]|Q26[5-9]
  • Operations: NOMESCO codes — ^FFC00|^FFC02|^FFC22|^FFC50|^FFC96

3 out of 7 registries used, show all original rules.

1466

4. Check minimum number of events

None

1466

5. Include endpoints

None

1466

6. Filter based on genotype QC (FinnGen only)

1466

Control definitions (FinnGen only)

Control exclude
Q17_CONGEN_MALFO_CIRCULATO_SYSTEM

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF6v3

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 13463 7684 5736
Only index persons 10427 6013 4414
Unadjusted period prevalence (%)
Whole population 0.19 0.22 0.16
Only index persons 0.20 0.22 0.17
Median age at first event (years)
Whole population 10.26 11.40 8.49
Only index persons 19.79 22.50 16.11

-FinnGen-

Key figures

All Female Male
Number of individuals 1466 900 566
Unadjusted period prevalence (%) 0.28 0.31 0.25
Median age at first event (years) 41.27 39.57 43.98

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1344
Matched controls
13352
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q21.10
ICD-10 Finland
Persistent ostium secundum
+∞
323.0
746
*
FFC22
NOMESCO Finland
Percutaneous transluminal closure of ostium secundum type ASD
+∞
323.0
354
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
47.6
323.0
624
238
Q21.19
ICD-10 Finland
Atrial septal defect NOS
+∞
323.0
387
*
Q21.11
ICD-10 Finland
Paten or persistent foramen ovale
+∞
322.5
297
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
10.0
242.5
566
907
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
8.1
227.7
632
1318
XF620
NOMESCO Finland
Examination of circulation with color method
458.9
203.5
199
5
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
26.8
200.6
284
132
FFC00
NOMESCO Finland
Suture of ostium secundum type ASD
+∞
191.9
180
*
B01AA03
ATC
warfarin; systemic
7.5
165.3
450
838
XF400
NOMESCO Finland
ECG with 12 standard connections
5.4
126.7
456
1158
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.0
124.9
772
3335
Q21.00
ICD-10 Finland
Multiple ventricular septal defect
+∞
122.5
116
*
7455A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ostium secundum type atrial septal defect
+∞
121.4
115
*
31
HP
Congenital heart failure surgery
+∞
112.8
107
*
Q21.08
ICD-10 Finland
Other specifed ventricular septal defect
+∞
102.1
97
*
Q21.09
ICD-10 Finland
Ventricular septal defect NOS
1047.0
101.2
98
*
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
37.2
95.6
123
36
201
Kela drug reimbursment
Chronic cardiac insufficiency
12.3
92.9
175
160
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
7.2
92.7
243
395
XF404
NOMESCO Finland
Ambulatory ECG
6.1
90.5
271
527
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
9.3
87.7
193
237
I48
ICD-10 Finland
Atrial fibrillation and flutter
4.6
85.4
346
941
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
6.2
85.2
253
484
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
17.8
84.9
136
84
Q21.18
ICD-10 Finland
Other spedified atrial septal defect
+∞
84.0
80
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
4.4
83.4
355
1011
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.3
78.6
339
971
C03CA01
ATC
furosemide; systemic
3.8
77.2
398
1335
5205
FHL
ASD blockage, secondary defect
+∞
71.3
68
*
FM2CE
NOMESCO Finland
NA
10.4
68.6
140
148
Q21.9
ICD-10 Finland
Congenital malformation of cardiac septum, unspecified
+∞
64.9
62
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.6
63.9
203
413
C01AA05
ATC
digoxin; systemic
7.2
63.3
163
252
PA2AE
NOMESCO Finland
Ultrasound examination of brain artery
621.0
61.1
60
*
WX872
NOMESCO Finland
Intensive care
8.1
60.5
143
194
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
20.2
58.0
88
46
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
57.8
510
2415
Q25.0
ICD-10 Finland
Patent ductus arteriosus
+∞
55.4
53
*
C03DA01
ATC
spironolactone; oral
4.8
55.0
198
460
74642
ICD-8 Finland
Congenital anomalies of heart, Defectus septi atriorum, ostium secundum
193.2
54.2
56
*
Q25.1
ICD-10 Finland
Coarctation of aorta
545.2
53.8
53
*
C07AB07
ATC
bisoprolol; oral
2.6
52.9
566
2955
TPH07
NOMESCO Finland
Cathetrisation of artery
4.2
52.8
225
616
ZXD10
NOMESCO Finland
Scheduled procedure
2.4
50.6
630
3543
207
Kela drug reimbursment
Chronic arrhythmias
4.1
50.3
216
594
Q21.1
ICD-10 Finland
Atrial septal defect
+∞
49.1
47
*
FFC50
NOMESCO Finland
Closure of ostium secundum type ASD using patch
+∞
49.1
47
*
TFP20
NOMESCO Finland
Cardiodefibrillation
5.6
48.4
150
293
XF622
NOMESCO Finland
Measurement of minute volume of heart
107.3
48.0
52
5
62
HP
Catheterization and pressure measurement of the right side of the heart
49.1
47.2
57
12
Q23.11
ICD-10 Finland
Bicuspid aortic valve
+∞
47.0
45
*
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
8.8
46.2
102
123
XF402
NOMESCO Finland
ECG with work load test
4.0
45.9
199
550
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
7.4
45.7
113
163
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.6
45.4
414
1942
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
47.3
45.3
55
12
Q22.1
ICD-10 Finland
Congenital pulmonary valve stenosis
448.8
44.4
44
*
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
7.1
43.6
111
167
XA800
NOMESCO Finland
Neuropsychological investigation
4.5
43.1
165
404
WX892
NOMESCO Finland
Monitored bed care
4.1
42.9
181
486
APK
HP
ASD closure
+∞
42.8
41
*
61
HP
Catheterization and pressure measurement of the left side of the heart
17.9
42.6
67
39
AF1
HP
Surgery of congenital heart defect
+∞
41.8
40
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.3
41.7
551
3103
ZXE20
NOMESCO Finland
More than three and less than five hours
3.1
40.8
258
954
Q21.20
ICD-10 Finland
Atrial septal defect of primum type
+∞
39.7
38
*
ZXE30
NOMESCO Finland
More than five and less than seven hours
4.8
39.3
139
313
APJ
HP
PFO closure
+∞
37.6
36
*
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.8
37.3
173
503
7456A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Endocardial cushion defects[DEFECTUS SEPTI ATRIORUM NUD]
+∞
35.5
34
*
Q21.21
ICD-10 Finland
Atrioventricular duct
+∞
35.5
34
*
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
5.2
35.4
116
240
I50.9
ICD-10 Finland
Heart failure, unspecified
3.7
35.0
165
485
B01AC04
ATC
clopidogrel; oral
3.3
34.5
194
655
5253
FHL
Cardiac lung machine
33.0
34.5
45
14
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
6.1
34.3
97
168
Q21.12
ICD-10 Finland
Defective sinus venosus
+∞
33.4
32
*
I34.1
ICD-10 Finland
Mitral (valve) prolapse
8.3
33.2
75
94
K78
ICPC
Atrial fibrillation/flutter
4.6
32.9
121
283
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
15.0
32.3
54
37
R4110
NOMESCO Finland
Physiotherapy
2.2
32.3
427
2336
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
12.8
32.3
58
47
Z2221
NOMESCO Finland
Medical doctor
2.2
32.0
450
2529
GAE10
NOMESCO Finland
Closure of previous incision of chest wall
115.3
31.7
34
*
XF600
NOMESCO Finland
Bloodpressure measurement
3.3
29.3
157
509
R4150
NOMESCO Finland
Neuropsychological rehabilitation
18.4
29.2
45
25
Q20.3
ICD-10 Finland
Discordant ventriculoarterial connection
+∞
29.2
28
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.3
28.9
306
1496
FFC42
NOMESCO Finland
Percutaneous closure of patent foramen ovale
+∞
28.1
27
*
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
3.1
28.0
167
583
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
10.0
27.7
56
58
AA1AD
NOMESCO Finland
CT of head and brain
2.4
27.2
278
1332
Q20.1
ICD-10 Finland
Double outlet right ventricle
+∞
27.1
26
*
FXA10
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia at concurrent surgical procedure
274.3
26.7
27
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.3
25.5
263
1260
I50.0
ICD-10 Finland
Congestive heart failure
4.7
25.5
90
202
R4120
NOMESCO Finland
Occupational therapy
3.3
25.2
136
442
Q21.0
ICD-10 Finland
Ventricular septal defect
+∞
25.0
24
*
Q26.3
ICD-10 Finland
Partial anomalous pulmonary venous connection
+∞
25.0
24
*
Q20.48
ICD-10 Finland
Single ventricle
+∞
25.0
24
*
B01AB05
ATC
enoxaparin; parenteral
2.1
24.5
342
1878
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
3.8
24.3
106
291
XFE00
NOMESCO Finland
Epicardial ultrasonography
7.4
24.1
58
81
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
5.5
24.0
72
135
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
4.2
23.8
93
231
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
3.0
23.2
141
497
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
20.3
23.0
34
17
AP2
HP
Catheterization of the right side of the heart
36.7
23.0
29
8
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
8.3
22.9
51
63
74639
ICD-8 Finland
Congenital anomalies of heart, Defectus septi ventriculorum
84.3
22.7
25
*
WX882
NOMESCO Finland
High dependency care
3.3
22.6
121
391
AN1
HP
Coronary angiography
3.1
22.3
132
458
ZXD05
NOMESCO Finland
Urgent procedure
1.9
21.9
416
2553
Q23.10
ICD-10 Finland
Congenital insufficiency of aortic valve
+∞
21.9
21
*
C07AA07
ATC
sotalol; systemic
5.5
21.8
66
125
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
21.8
305
1667
TPX22
NOMESCO Finland
Intravenous arterial thrombolysis
14.0
21.8
37
27
I49.5
ICD-10 Finland
Sick sinus syndrome
5.3
21.4
66
128
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
4.2
21.4
83
205
AP3
HP
Catheterization of the right and left side of the heart
50.5
21.1
25
5
Q21.30
ICD-10 Finland
Tetralogy of Fallot
+∞
20.8
20
*
FFC96
NOMESCO Finland
Other closure of isolated atrial septal defect
+∞
20.8
20
*
Q26.1
ICD-10 Finland
Persistent left superior vena cava
+∞
20.8
20
*
7454B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ventricular septal defect[DEFECTUS SEPTI VENTRICULORUM SIMPLEX]
+∞
20.8
20
*
C01BD01
ATC
amiodarone; systemic
6.5
20.2
53
84
XX3BT
NOMESCO Finland
Other labeling with X-ray guidance
7.4
20.2
48
66
Z95.8
ICD-10 Finland
Presence of other cardiac and vascular implants and grafts
58.0
19.9
23
*
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
16.6
19.6
31
19
FKB10
NOMESCO Finland
Annuloplasty of mitral valve for insufficiency using ring
12.3
19.5
35
29
R06.0
ICD-10 Finland
Dyspnoea
2.0
19.2
286
1593
FDF05
NOMESCO Finland
Percutaneous transluminal occlusion of aorto-pulmonary collaterals
+∞
18.7
18
*
FHB50
NOMESCO Finland
Transatrial closure of VSD using patch
+∞
18.7
18
*
XF640
NOMESCO Finland
NA
5.6
18.4
54
99
ZXE00
NOMESCO Finland
One hour or less
1.7
18.2
552
3878
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.5
18.0
147
618
Q23.0
ICD-10 Finland
Congenital stenosis of aortic valve
+∞
17.7
17
*
Q23.4
ICD-10 Finland
Hypoplastic left heart syndrome
+∞
17.7
17
*
C09AA05
ATC
ramipril; oral
2.0
17.5
236
1257
XF614
NOMESCO Finland
Measurement of pulmonary artery pressure
95.6
17.5
19
*
K90
ICPC
Stroke/cerebrovascular accident
6.2
17.4
47
78
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
4.7
17.3
59
129
C07AB02
ATC
metoprolol; systemic
2.1
17.2
208
1059
C01BC04
ATC
flecainide; systemic
4.8
17.0
57
122
FGC10
NOMESCO Finland
Annuloplasty of tricuspid valve using prosthetic ring
25.8
16.9
23
9
TFP34
NOMESCO Finland
Electrophysiological investigation
4.9
16.7
55
116
Q25.40
ICD-10 Finland
Aortic hypoplasia
+∞
16.7
16
*
I37.1
ICD-10 Finland
Pulmonary valve insufficiency
+∞
16.7
16
*
FBE10
NOMESCO Finland
Expansion or reconstruction of pulmonary artery using patch
+∞
16.7
16
*
R07.4
ICD-10 Finland
Chest pain, unspecified
1.9
16.6
298
1764
FN1CD
NOMESCO Finland
Very extensive CT of coronary arteries
12.8
16.6
29
23
Z3231
NOMESCO Finland
Registered nurse
1.7
16.5
421
2792
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
4.0
16.5
66
169
I49.3
ICD-10 Finland
Ventricular premature depolarization
3.1
16.4
93
313
G04BE03
ATC
sildenafil; oral
9.6
16.4
33
35
WX704
NOMESCO Finland
Intubation
2.8
16.1
110
418
81
HP
Angiography of the heart and coronary arteries
3.8
15.9
68
185
WX402
NOMESCO Finland
General anaesthesia
1.9
15.8
267
1543
FAE00
NOMESCO Finland
Anastomosis to pulmonary artery from superior vena cava
+∞
15.6
15
*
FFC32
NOMESCO Finland
Percutaneous transluminal closure of sinus venosus type ASD
+∞
15.6
15
*
Z98.8
ICD-10 Finland
Other specified postsurgical states
7.0
15.6
38
55
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
5.3
15.6
47
90
B01AF02
ATC
apixaban; oral
2.8
15.5
102
377
74646
ICD-8 Finland
Congenital anomalies of heart, Defectus septi atriorum, ostium primum
160.6
15.5
16
*
I35.0
ICD-10 Finland
Aortic (valve) stenosis
3.8
15.0
63
169
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.5
14.9
117
483
I37.0
ICD-10 Finland
Pulmonary valve stenosis
56.9
14.8
17
*
I48.4
ICD-10 Finland
Atypical atrial flutter
56.9
14.8
17
*
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
2.3
14.6
144
667
FDA00
NOMESCO Finland
Aortoplasty and aorto-pulmonary shunt for HLHS
+∞
14.6
14
*
5255
FHL
Deep hypothermia (<20 °) with cardiopulmonary resuscitation
+∞
14.6
14
*
Q21.29
ICD-10 Finland
Atrioventricular septal defect UNS
+∞
14.6
14
*
Q24.4
ICD-10 Finland
Congenital subaortic stenosis
+∞
14.6
14
*
Q22.5
ICD-10 Finland
Ebstein anomaly
+∞
14.6
14
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.2
14.5
157
758
RS224
NOMESCO Finland
NA
7.3
14.4
34
47
Q87.14
ICD-10 Finland
Noonan's syndrome
150.5
14.4
15
*
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
6.2
14.4
38
62
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.4
14.3
122
526
FM1CD
NOMESCO Finland
Very extensive CT of heart
27.3
14.2
19
7
FN1CC
NOMESCO Finland
Very extensive angiography of heart and/or coronary arteries
8.1
14.0
31
39
TFP35
NOMESCO Finland
Electroanatomical mapping
8.9
13.9
29
33
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
15.8
13.9
22
14
ZXE40
NOMESCO Finland
More than seven and less than nine hours
4.0
13.8
55
141
74663
ICD-8 Finland
Congenital anomalies of heart, Stenosis valvulae pulmonalis
75.4
13.6
15
*
Q23.3
ICD-10 Finland
Congenital mitral insufficiency
+∞
13.5
13
*
FAE10
NOMESCO Finland
Bidirectional anastomosis between superior vena cava and pulmonary artery
+∞
13.5
13
*
FWD00
NOMESCO Finland
Reoperation for superficial haemorrhage in surgery of heart and major thoracic vessels
12.9
13.4
23
18
C10AA05
ATC
atorvastatin; oral
1.7
13.3
327
2126
I48.2
ICD-10 Finland
Chronic atrial fibrillation
6.1
13.1
35
58
GE1BE
NOMESCO Finland
Mediastinal ultrasound examinaiton through oesophagus
40.2
13.1
16
*
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
5.9
13.1
36
62
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
3.7
13.1
57
158
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
4.4
13.0
47
110
I47.1
ICD-10 Finland
Supraventricular tachycardia
3.1
13.0
71
235
K84
ICPC
Heart disease other
5.0
12.7
40
81
FN1BB
NOMESCO Finland
Contrast angiography of heart and/or coronary arteries after bypass surgery
9.7
12.7
25
26
I44.2
ICD-10 Finland
Atrioventricular block, complete
5.4
12.7
37
69
Z3226
NOMESCO Finland
Physiotherapist
1.7
12.5
291
1854
FBE35
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery with insertion of stent
+∞
12.5
12
*
7460C
ICD-9 Finland
Other congenital anomalies of heart, Anomalies of pulmonary valve[VITIUM VALVULAE PULMONALIS CONGENITA CUM STENOSIS]
+∞
12.5
12
*
FPF20
NOMESCO Finland
Implantation of epicardial pacemaker with atrial and ventricular electrodes
+∞
12.5
12
*
74699
ICD-8 Finland
Congenital anomalies of heart, Unspecified anomalies of heart
+∞
12.5
12
*
FBE32
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery
+∞
12.5
12
*
R04.0
ICD-10 Finland
Epistaxis
2.6
12.2
88
346
I27.0
ICD-10 Finland
Primary pulmonary hypertension
21.3
12.0
17
8
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
13.4
11.9
20
15
FEB10
NOMESCO Finland
Decompression and drainage of pericardium
14.7
11.7
19
13
Q21.2
ICD-10 Finland
Atrioventricular septal defect
+∞
11.4
11
*
Q25.78
ICD-10 Finland
Other congenital malformations of pulmonary artery
+∞
11.4
11
*
Q25.41
ICD-10 Finland
Persistent right-sided aortic arch
+∞
11.4
11
*
FJF20
NOMESCO Finland
Replacement of pulmonary valve using homograft
+∞
11.4
11
*
Q24.3
ICD-10 Finland
Pulmonary infundibular stenosis
+∞
11.4
11
*
602
Kela drug reimbursment
Children's severe malnutrition
3.9
11.4
46
120
R1260
NOMESCO Finland
Evaluation of communicative skills
4.6
11.4
39
87
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
11.4
537
4079
I34.01
ICD-10 Finland
Mitral (valve) regurgitation NOS or of specified cause, except rheumatic
11.8
11.3
20
17
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
15.1
11.3
18
12
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
11.2
211
1257
Q90.9
ICD-10 Finland
Down syndrome, unspecified
25.1
11.1
15
6
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.6
11.1
354
2451
TFC20
NOMESCO Finland
Catheterisation of both sides of heart
43.4
10.9
13
*
I44.1
ICD-10 Finland
Atrioventricular block, second degree
6.1
10.7
28
46
I47.2
ICD-10 Finland
Ventricular tachycardia
5.1
10.6
32
63
I42.0
ICD-10 Finland
Dilated cardiomyopathy
4.3
10.5
38
90
I50.1
ICD-10 Finland
Left ventricular failure
3.5
10.5
48
140
K83
ICPC
Heart valve disease NOS
8.5
10.5
22
26
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
4.0
10.5
41
105
Q25.6
ICD-10 Finland
Stenosis of pulmonary artery
+∞
10.4
10
*
Q20.40
ICD-10 Finland
Double inlet left ventricle
+∞
10.4
10
*
Q24.8
ICD-10 Finland
Other specified congenital malformations of heart
+∞
10.4
10
*
FAE30
NOMESCO Finland
Total cavo-pulmonary connection using fenestrated patch
+∞
10.4
10
*
7454A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ventricular septal defect[DEFECTUS SEPTI VENTRICULORUM NUD]
+∞
10.4
10
*
J01CA04
ATC
amoxicillin; systemic
1.6
10.3
1105
9907
ZXY02
NOMESCO Finland
Neuropsychologist
7.7
10.3
23
30
I97.0
ICD-10 Finland
Postcardiotomy syndrome
16.1
10.3
16
10
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
3.1
10.3
55
181
WX002
NOMESCO Finland
Sedation and analgesia
1.7
10.2
215
1322
7AX01
NOMESCO Finland
NA
13.1
10.1
17
13
I27.9
ICD-10 Finland
Pulmonary heart disease, unspecified
13.1
10.1
17
13
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.9
10.0
162
914
R50.9
ICD-10 Finland
Fever, unspecified
1.7
10.0
218
1355
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.7
9.9
242
1555
FPD00
NOMESCO Finland
Maze procedure for atrial fibrillation
40.1
9.9
12
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.5
9.9
79
329
AC4
HP
MVP
16.7
9.8
15
9
Q90.0
ICD-10 Finland
Trisomy 21, meiotic nondisjunction
26.0
9.8
13
5
R42
ICD-10 Finland
Dizziness and giddiness
1.7
9.8
219
1375
H53.4
ICD-10 Finland
Visual field defects
5.0
9.7
30
61
ZX199
NOMESCO Finland
Other rote
7.4
9.7
22
30
51
HP
Other heart surgery
55.0
9.6
11
*
XXA00
NOMESCO Finland
Clinical examination requiring general anaesthesia
5.8
9.6
26
45
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
4.3
9.5
34
80
I63
ICD-10 Finland
Cerebral infarction
11.4
9.5
17
15
I44.0
ICD-10 Finland
Atrioventricular block, first degree
8.4
9.5
20
24
PA6BG
NOMESCO Finland
MRI examination of neck vasculature with high intensity magnet
10.0
9.5
18
18
PD5BD
NOMESCO Finland
Extensive CT of aorta
4.8
9.4
30
63
R62.0
ICD-10 Finland
Delayed milestone
3.1
9.4
51
170
ZSF00
NOMESCO Finland
Procedure related to previous procedure classified in chapter F
30.0
9.4
12
*
Q24.6
ICD-10 Finland
Congenital heart block
+∞
9.4
9
*
Q22.0
ICD-10 Finland
Pulmonary valve atresia
+∞
9.4
9
*
I51.0
ICD-10 Finland
Cardiac septal defect, acquired
+∞
9.4
9
*
7471A
ICD-9 Finland
Other congenital anomalies of circulatory system, Coarctation of aorta[COARCTATIO AORTAE]
+∞
9.4
9
*
5207
FHL
VSD closure
+∞
9.4
9
*
Q24.0
ICD-10 Finland
Dextrocardia
+∞
9.4
9
*
Q25.3
ICD-10 Finland
Stenosis of aorta
+∞
9.4
9
*
APX
HP
Other cardiac catheter operation
+∞
9.4
9
*
K80
ICPC
Cardiac arrhythmia NOS
2.3
9.3
84
372
FXA20
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia and circulatory arrest at concurrent surgical procedure
21.7
9.3
13
6
TFP30
NOMESCO Finland
Cathetric examination for cardiac arrythmia
6.9
9.3
22
32
I63.0
ICD-10 Finland
Cerebral infarction due to thrombosis of precerebral arteries
8.7
9.2
19
22
R01.1
ICD-10 Finland
Cardiac murmur, unspecified
3.1
9.2
48
156
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.4
9.1
73
307
Z94.1
ICD-10 Finland
Heart transplant status
11.5
9.0
16
14
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
5.9
9.0
24
41
RK260
NOMESCO Finland
NA
15.6
9.0
14
9
FP4B5
NOMESCO Finland
ECG, prolonged recording (24 h)
7.4
8.9
20
27
FPD96
NOMESCO Finland
Other operation for atrial fibrillation
24.0
8.9
12
5
I63.1
ICD-10 Finland
Cerebral infarction due to embolism of precerebral arteries
8.0
8.8
19
24
UGC02
NOMESCO Finland
Rigid bronchoscopy
8.6
8.8
18
21
B01AE07
ATC
dabigatran etexilate; oral
3.3
8.7
42
129
Z2445
NOMESCO Finland
Psychologist
2.0
8.7
108
554
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
3.0
8.7
47
157
WW502
NOMESCO Finland
Autotransfusion
14.0
8.7
14
10
PA2VT
NOMESCO Finland
Intravascular evacuation of brain artery embolus
14.0
8.7
14
10
C02KX01
ATC
bosentan; oral
49.9
8.7
10
*
3A064
NOMESCO Finland
NA
16.3
8.5
13
8
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
4.0
8.5
32
80
I49.4
ICD-10 Finland
Other and unspecified premature depolarization
3.2
8.5
43
137
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
2.1
8.5
98
489
1CX08
NOMESCO Finland
NA
20.0
8.4
12
6
I71.2
ICD-10 Finland
Thoracic aortic aneurysm, without mention of rupture
4.0
8.4
32
81
TFP45
NOMESCO Finland
Ablation treatment of non-typical atrial flutter
89.9
8.4
9
*
AH3
HP
Treatment of arrhythmias, eg atrial fibrillation, in conjunction with other cardiac surgery
89.9
8.4
9
*
Z2446
NOMESCO Finland
Social worker
1.8
8.4
143
825
Q21.80
ICD-10 Finland
Communication from left ventricle to right atrium
+∞
8.3
8
*
Q24.9
ICD-10 Finland
Congenital malformation of heart, unspecified
+∞
8.3
8
*
7456C
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Endocardial cushion defects[ASD CANALIS ATRIOVENTRICULARIS COMMUNIS]
+∞
8.3
8
*
FDE10
NOMESCO Finland
Ligature of patent ductus arteriosus
+∞
8.3
8
*
FBJ10
NOMESCO Finland
Anastomosis to pulmonary artery from subclavian artery with interposition graft
+∞
8.3
8
*
AE1
HP
Pulmonary artery thrombendarterectomy
+∞
8.3
8
*
PA6AG
NOMESCO Finland
Limited MRI examination of neck vasculature with high intensity magnet
9.4
8.2
16
17
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
3.3
8.2
39
119
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
3.4
8.2
38
114
PA7CD
NOMESCO Finland
CT angiography of neck and brain, extensive
6.0
8.1
21
35
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.6
8.0
211
1377
AD1
HP
TVP
22.0
8.0
11
5
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.0
7.8
95
482
C09AA02
ATC
enalapril; systemic
1.7
7.8
163
996
FPH00
NOMESCO Finland
Transvenous extraction of transvenous cardiac pacemaker or cardioverter-defibrillator
25.0
7.5
10
*
FKC50
NOMESCO Finland
Repair of mitral valve for insufficiency using prosthetic chord
8.8
7.5
15
17
AP1
HP
Catheterization of the left side of the heart
5.4
7.5
21
39
ZX120
NOMESCO Finland
Intravenous
1.9
7.4
114
634
7470A
ICD-9 Finland
Other congenital anomalies of circulatory system, Patent ductus arteriosus
79.9
7.4
8
*
1EA01
NOMESCO Finland
NA
79.9
7.4
8
*
FPW96
NOMESCO Finland
Other operation for arhythmia or disturbance of impulse propagation
13.3
7.4
12
9
I48.3
ICD-10 Finland
Typical atrial flutter
13.3
7.4
12
9
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
5.3
7.3
21
40
R00.2
ICD-10 Finland
Palpitations
2.0
7.3
87
441
WX870
NOMESCO Finland
Other postsurgical intensive care
8.4
7.3
15
18
FLE96
NOMESCO Finland
Other repair of outlet obstruction of left ventricle
+∞
7.3
7
*
FHB00
NOMESCO Finland
Transatrial suture of VSD
+∞
7.3
7
*
Q20.8
ICD-10 Finland
Other congenital malformations of cardiac chambers and connections
+∞
7.3
7
*
90492
NOMESCO Finland
NA
+∞
7.3
7
*
74689
ICD-8 Finland
Congenital anomalies of heart, Aliae definitae
+∞
7.3
7
*
Q25.48
ICD-10 Finland
Other congenital malformations of the aorta
+∞
7.3
7
*
FFF20
NOMESCO Finland
Anastomosis to left atrium from partially anomalous pulmonary veins
+∞
7.3
7
*
Q21.31
ICD-10 Finland
Tetralogy of Fallot and double outlet right ventricle
+∞
7.3
7
*
7451B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Transposition of great vessels[DOUBLE OUTLET RIGHT VENTRICLE]
+∞
7.3
7
*
74629
ICD-8 Finland
Congenital anomalies of heart, Tetralogy of Fallot
+∞
7.3
7
*
FM1BD
NOMESCO Finland
Extensive CT of heart
10.8
7.3
13
12
3810A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Acute nonsuppurative otitis media
9.3
7.3
14
15
C01BD07
ATC
dronedarone; oral
9.3
7.3
14
15
I49.1
ICD-10 Finland
Atrial premature depolarization
3.0
7.2
39
132
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.4
7.2
370
2799
I34.2
ICD-10 Finland
Nonrheumatic mitral (valve) stenosis
30.0
7.1
9
*
FPD10
NOMESCO Finland
Surgical ablation of atrial fibrillation
30.0
7.1
9
*
XQ903
NOMESCO Finland
Production of other scan or drawing
30.0
7.1
9
*
K91
ICPC
Cerebrovascular disease
6.6
7.1
17
26
FP1B5
NOMESCO Finland
Resting ECG, 12 leads
3.9
7.0
27
70
K99
ICPC
Cardiovascular disease other
3.8
7.0
28
75
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.6
7.0
168
1072
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
4.3
7.0
24
56
TFP46
NOMESCO Finland
Ablation treatment of atrial fibrillation
4.7
7.0
22
47
R47.0
ICD-10 Finland
Dysphasia and aphasia
7.0
7.0
16
23
TFP44
NOMESCO Finland
Ablation treatment of typical atrial flutter
7.0
7.0
16
23
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
1.9
6.9
102
560
J96.1
ICD-10 Finland
Chronic respiratory failure
5.5
6.9
19
35
FM1NE
NOMESCO Finland
Ultrasound examination of fetal heart
13.7
6.9
11
8
FKC60
NOMESCO Finland
Resection and reconstruction of leaflet of mitral valve for insufficiency
13.7
6.9
11
8
F83
ICD-10 Finland
Mixed specific developmental disorders
2.8
6.8
41
149
RS221
NOMESCO Finland
NA
3.2
6.8
33
104
AAL10
NOMESCO Finland
Intracranial endovascular thrombolysis
10.9
6.8
12
11
4273A
ICD-9 Finland
Cardiac dysrhythmias, Atrial fibrillation and flutter
5.0
6.8
20
40
I48.1
ICD-10 Finland
Persistent atrial fibrillation
4.0
6.7
25
63
Z31.5
ICD-10 Finland
Genetic counselling
2.0
6.7
83
427
TKC20
NOMESCO Finland
Catheterisation of bladder
2.2
6.7
65
302
FFW96
NOMESCO Finland
Other operation on atria
40.0
6.7
8
*
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
2.3
6.7
59
260
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
4.3
6.7
23
54
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
3.3
6.6
31
95
C10AA01
ATC
simvastatin; oral
1.4
6.6
314
2336
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
2.0
6.5
77
388
B01AF01
ATC
rivaroxaban; oral
1.9
6.5
95
519
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.1
6.5
73
363
FGD00
NOMESCO Finland
Repair of tricuspid valve using suture
69.7
6.4
7
*
FFC40
NOMESCO Finland
Closure of Patent Foramen Ovale
69.7
6.4
7
*
I28.8
ICD-10 Finland
Other specified diseases of pulmonary vessels
69.7
6.4
7
*
Q90.1
ICD-10 Finland
Trisomy 21, mosaicism (mitotic nondisjunction)
69.7
6.4
7
*
A12BA01
ATC
potassium chloride; oral
2.9
6.4
37
130
342
Kela drug reimbursment
Dronedarone
7.4
6.4
14
19
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
1.9
6.4
84
443
73
HP
Initial pacemaker installation
8.1
6.3
13
16
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
2.9
6.3
36
125
H66.0
ICD-10 Finland
Acute suppurative otitis media
1.5
6.3
190
1284
Q21
ICD-10 Finland
Congenital malformations of cardiac septa
+∞
6.2
6
*
FHE30
NOMESCO Finland
Repair of tetralogy of Fallot with transannular patch
+∞
6.2
6
*
Q20.60
ICD-10 Finland
Left isomerism of atrial appendages
+∞
6.2
6
*
Q21.15
ICD-10 Finland
Common atrium
+∞
6.2
6
*
Q20.5
ICD-10 Finland
Discordant atrioventricular connection
+∞
6.2
6
*
FM2FN
NOMESCO Finland
Intra cardiac shunt isotope imaging
+∞
6.2
6
*
FLE10
NOMESCO Finland
Myotomy or myectomy of left ventricle for outlet obstruction
+∞
6.2
6
*
FFF96
NOMESCO Finland
Other operation for partially anomalous pulmonary veins
+∞
6.2
6
*
FDE32
NOMESCO Finland
Percutaneous transluminal closure of patent ductus arteriosus
+∞
6.2
6
*
FJF10
NOMESCO Finland
Replacement of pulmonary valve using biological prosthesis
+∞
6.2
6
*
FJE42
NOMESCO Finland
Percutaneous transluminal expansion of pulmonary valve
+∞
6.2
6
*
Q21.81
ICD-10 Finland
Eisenmenger's syndrome
+∞
6.2
6
*
FXA13
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia and exclusive cerebral perfusion
+∞
6.2
6
*
Q25.21
ICD-10 Finland
Interrupted aortic arch
+∞
6.2
6
*
FKC96
NOMESCO Finland
Other repair of mitral valve for insufficiency
26.6
6.2
8
*
FM1AD
NOMESCO Finland
CT of heart
26.6
6.2
8
*
Z95.9
ICD-10 Finland
Presence of cardiac and vascular implant and graft, unspecified
26.6
6.2
8
*
GD1LA
NOMESCO Finland
GD
4.5
6.1
20
45
I34.0
ICD-10 Finland
Mitral (valve) insufficiency
4.5
6.1
20
45
127
Kela drug reimbursment
Transplant complication
3.0
6.1
32
107
H52.2
ICD-10 Finland
Astigmatism
2.8
6.1
36
130
H53.0
ICD-10 Finland
Amblyopia ex anopsia
3.3
6.0
28
86

Mortality – FinRegistry

↥

Association

Association between endpoint Q17_ASD and mortality.

Females

Parameter HR [95% CI] p-value
Q17_ASD 1.807 [1.57, 2.09] < 0.001
Birth year 0.999 [0.99, 1.01] 0.845

During the follow-up period (1.1.1998 — 31.12.2019), 451 out of 5990 females with Q17_ASD died.

Males

Parameter HR [95% CI] p-value
Q17_ASD 1.752 [1.5, 2.04] < 0.001
Birth year 0.987 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 363 out of 4494 males with Q17_ASD died.

Mortality risk

Mortality risk for people of age

years, who have Q17_ASD.

N-year risk Females Males
1 0.2% 0.337%
5 1.099% 2.003%
10 2.988% 5.23%
15 5.839% 9.857%
20 10.621% 15.809%

Relationships between endpoints

↥

Index endpoint: Q17_ASD – Atrial septal defect

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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