Crohn's disease: A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1638 |
4. Check minimum number of eventsNone |
1638 |
5. Include endpointsNone |
1638 |
6. Filter based on genotype QC (FinnGen only) |
1638 |
Control definitions (FinnGen only)
- Control exclude
- K11_ENERCOLNONINF
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- K51
- Name in latin
- Ileocolitis ulcerosa [chronica]
Similar endpoints
↥List of similar endpoints to
Ulcerative ileocolitis
based on the number of shared cases.
Similar with more cases:
- Ulcerative colitis
- Inflammatory bowel disease
- Noninfective enteritis and colitis
- Autoimmune diseases related-to ILD
- Autoimmune diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7929 | 3602 | 4295 |
| Only index persons | 7575 | 3493 | 4082 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.11 | 0.10 | 0.12 |
| Only index persons | 0.14 | 0.13 | 0.16 |
| Median age at first event (years) | |||
| Whole population | 41.83 | 40.60 | 42.72 |
| Only index persons | 41.12 | 40.19 | 41.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1638 | 856 | 782 |
| Unadjusted period prevalence (%) | 0.32 | 0.29 | 0.34 |
| Median age at first event (years) | 42.23 | 39.28 | 45.47 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1519
- Matched controls
- 15191
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K51.8
ICD-10 Finland
Other ulcerative colitis
+∞
323.0
470
*
UJF14
NOMESCO Finland
Enteroscopy of ileoanal anastomosis
1289.2
323.0
309
*
UJF32
NOMESCO Finland
Coloscopy
41.7
323.0
1271
1662
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
+∞
323.0
636
*
K51.5
ICD-10 Finland
Left sided colitis
4503599627370496.0
323.0
1172
*
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
+∞
323.0
1412
*
K51.2
ICD-10 Finland
Ulcerative (chronic) proctitis
+∞
323.0
307
*
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
+∞
323.0
344
*
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
6344.7
323.0
1030
5
A07EC02
ATC
mesalazine; oral, rectal
2660.0
323.0
1372
53
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
+∞
323.0
1515
*
H02AB06
ATC
prednisolone; systemic
13.7
323.0
1292
4457
UJF30
NOMESCO Finland
Ileoscopy through colon
30.3
323.0
745
468
K50.1
ICD-10 Finland
Crohn disease of large intestine
+∞
323.0
305
*
A07EA02
ATC
hydrocortisone; rectal
509.7
323.0
694
25
A07EA06
ATC
budesonide; oral, local oral
351.0
323.0
571
26
L04AX01
ATC
azathioprine; systemic
187.2
323.0
929
127
K50.8
ICD-10 Finland
Other Crohn disease
3325.5
305.7
285
*
K51
ICD-10 Finland
Ulcerative colitis
1690.5
294.6
277
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
7.3
260.3
827
2126
H02AB07
ATC
prednisone; oral
9.5
247.7
587
946
K50.9
ICD-10 Finland
Crohn disease, unspecified
+∞
241.2
225
*
A07EC01
ATC
sulfasalazine; oral, rectal
12.0
231.4
462
533
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
12.9
230.4
442
469
L01BB02
ATC
mercaptopurine; oral
237.2
221.1
223
11
K50.0
ICD-10 Finland
Crohn disease of small intestine
+∞
211.5
198
*
J01MA02
ATC
ciprofloxacin; systemic
5.3
198.0
936
3535
UJF12
NOMESCO Finland
Enteroscopy through intestinal stoma
+∞
196.2
184
*
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
+∞
188.5
177
*
P01AB01
ATC
metronidazole; oral, rectal
5.0
187.7
956
3827
D94
ICPC
Chronic enteritis/ulcerative colitis
2012.4
179.8
171
*
A07EA01
ATC
prednisolone; rectal
446.2
163.8
161
*
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
50.4
160.4
194
44
ZX120
NOMESCO Finland
Intravenous
8.1
153.5
382
605
JFH30
NOMESCO Finland
Total colectomy, mucosal proctectomy and ileoanal anastomosis without ileostomy
1553.2
146.3
140
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.6
145.3
656
2144
JFG00
NOMESCO Finland
Closure of loop enterostomy without resection
101.7
134.8
147
16
56310
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Ulcerative colitis
+∞
134.4
127
*
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
100.3
125.4
137
15
M07.5*K51.9
ICD-10 Finland
Arthropathy in ulcerative colitis
+∞
118.3
112
*
K83.0
ICD-10 Finland
Cholangitis
44.8
118.1
146
36
5562A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) proctitis
+∞
116.1
110
*
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
90.8
113.1
125
15
WX302
NOMESCO Finland
Thoracal epidural anesthesy
9.9
108.2
230
269
TPH04
NOMESCO Finland
Cathetrisation of vein
4.2
105.8
493
1564
5561A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) ileocolitis
+∞
95.9
91
*
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
16.9
95.6
156
102
4AA12
NOMESCO Finland
NA
492.3
94.4
93
*
WX002
NOMESCO Finland
Sedation and analgesia
4.0
92.6
453
1473
A05AA02
ATC
ursodeoxycholic acid; oral
20.9
90.2
136
71
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
5.5
85.0
279
601
A07EC03
ATC
olsalazine; oral
+∞
84.1
80
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.0
83.2
742
3713
H02AB09
ATC
hydrocortisone; systemic
15.3
82.7
140
100
A02BC02
ATC
pantoprazole; systemic
3.0
82.5
1078
6871
5568X
ICD-9 Finland
Idiopathic proctocolitis, Other ulcerative colitis
+∞
82.0
78
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.7
80.1
419
1416
JFH10
NOMESCO Finland
Total colectomy and ileostomy
270.3
76.2
77
*
L04AB04
ATC
adalimumab; parenteral
14.0
73.5
129
100
JFH33
NOMESCO Finland
Total colectomy, mucosal proctectomy, ileoanal anastomosis and ileostomy
+∞
72.5
69
*
JFF10
NOMESCO Finland
Loop enterostomy
59.2
71.6
84
15
JGB50
NOMESCO Finland
Mucosal proctectomy and ileoanal anastomosis
+∞
71.4
68
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
8.3
70.8
164
217
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
22.2
69.3
102
49
4AB02
NOMESCO Finland
NA
125.9
67.5
72
6
L04AD01
ATC
ciclosporin; systemic
13.8
67.5
119
93
JN3BD
NOMESCO Finland
Extensive abdominal CT
4.3
65.9
272
732
UJF92
NOMESCO Finland
Capsular endoscopy
16.3
59.8
98
64
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
5.7
59.4
183
358
WX408
NOMESCO Finland
General anesthesy, balanced
2.6
54.4
510
2459
A06AC01
ATC
ispaghula (psylla seeds); oral
2.8
53.2
408
1740
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
16.5
52.9
86
55
A07DA03
ATC
loperamide; oral
7.8
52.6
126
174
Z93.2
ICD-10 Finland
Ileostomy status
76.8
52.4
59
8
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.7
51.4
252
779
J01MA12
ATC
levofloxacin; systemic
3.0
50.5
335
1297
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
3.7
49.7
239
725
C10AC01
ATC
colestyramine; oral
10.5
49.1
98
99
N02AX02
ATC
tramadol; systemic, rectal
2.3
47.3
676
3977
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
13.5
46.5
82
64
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
49.8
44.1
53
11
K50
ICD-10 Finland
Crohn disease [regional enteritis]
+∞
44.0
42
*
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
3.6
43.7
214
655
WVA20
NOMESCO Finland
Medicine administration
9.4
43.6
92
103
K56.7
ICD-10 Finland
Ileus, unspecified
16.1
43.5
71
46
1370
FHL
Colonoscopy, whole colon
48.9
43.1
52
11
JFH11
NOMESCO Finland
Laparoscopic colectomy
+∞
42.9
41
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.1
42.1
259
941
M07.5
ICD-10 Finland
Arthropathy in ulcerative colitis
+∞
41.9
40
*
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
15.8
41.3
68
45
WX402
NOMESCO Finland
General anaesthesia
2.7
41.0
329
1416
JFG20
NOMESCO Finland
Closure of enterostomy with resection of exteriorised loop
55.0
40.7
48
9
JF1BD
NOMESCO Finland
Very extensive small bowel CT
53.8
39.7
47
9
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
39.7
602
3559
3AC01
NOMESCO Finland
NA
15.4
39.1
65
44
JFF13
NOMESCO Finland
Terminal enterostomy
88.5
39.0
43
5
M07.4*K50.9
ICD-10 Finland
Arthropathy in Crohn's disease [regional enteritis]
+∞
38.7
37
*
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
16.0
38.5
63
41
JF2AB
NOMESCO Finland
Colongraphy with X-ray
44.0
38.3
47
11
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
4.9
38.3
132
290
UJK12
NOMESCO Finland
Peroral cholangioscopy
64.7
38.3
44
7
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
7.5
37.8
92
130
UJK02
NOMESCO Finland
ERCP
9.0
37.1
80
93
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.4
36.3
368
1786
4AA33
NOMESCO Finland
NA
+∞
35.6
34
*
JFG73
NOMESCO Finland
Excision of ileal pelvic pouch
+∞
35.6
34
*
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
9.3
35.1
74
83
R50.9
ICD-10 Finland
Fever, unspecified
2.7
34.3
263
1090
JN3AD
NOMESCO Finland
Abdominal CT examination
3.7
34.1
159
464
B01AB05
ATC
enoxaparin; parenteral
2.2
33.6
448
2457
Z93
ICD-10 Finland
Artificial opening status
51.3
33.6
40
8
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
15.4
33.3
55
37
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
7.6
32.5
78
108
M09.2*K51.9
ICD-10 Finland
Juvenile arthritis in ulcerative colitis
+∞
32.4
31
*
UJG02
NOMESCO Finland
Proctoscopy
8.9
32.4
70
82
K60.3
ICD-10 Finland
Anal fistula
7.8
32.3
76
102
A02BC01
ATC
omeprazole; systemic
2.2
32.2
425
2317
L04AA01
ATC
[U] ciclosporin; systemic
10.6
32.1
63
62
JF1DG
NOMESCO Finland
Small bowel very extensive MRI with with high intensity magnet
48.6
31.7
38
8
JH1CG
NOMESCO Finland
Extensive MRI of perianal area
32.4
31.4
41
13
JHA00
NOMESCO Finland
Anal or perianal incision
9.3
31.3
66
74
JFH20
NOMESCO Finland
Proctocolectomy and ileostomy
308.3
29.9
30
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.9
29.8
130
358
JAH00
NOMESCO Finland
Laparotomy
7.4
29.8
72
101
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
15.3
29.7
49
33
L04AC05
ATC
ustekinumab; parenteral
37.9
29.4
37
10
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
6.3
29.0
79
131
K51.4
ICD-10 Finland
Inflammatory polyps
+∞
28.2
27
*
JFG40
NOMESCO Finland
Revision of enterostomy or colostomy without laparotomy
65.3
28.0
32
5
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
7.7
27.3
64
86
5560A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) enterocolitis
+∞
27.2
26
*
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
4.7
26.8
94
210
JHD00
NOMESCO Finland
Anal dilatation
15.8
26.5
43
28
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
4.6
25.8
92
209
B01AB10
ATC
tinzaparin; parenteral
3.4
25.8
130
403
A07AA09
ATC
vancomycin; oral
12.5
25.1
45
37
L04AB06
ATC
golimumab; parenteral
14.4
24.9
42
30
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.6
24.8
192
791
SPAT1262
SPAT
Handing over of treatment supplies
2.3
24.6
268
1318
JFA58
NOMESCO Finland
Endoscopic dilatation of colon
57.0
24.1
28
5
3042
Kela drug reimbursment
NA
+∞
24.0
23
*
253
Kela drug reimbursment
NA
+∞
24.0
23
*
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
4.7
24.0
84
188
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
6.5
23.8
63
101
A02BC05
ATC
esomeprazole; systemic
1.8
23.6
580
3892
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
4.4
23.3
86
203
JFB00
NOMESCO Finland
Partial resection of small intestine
8.2
22.8
51
64
B03BA03
ATC
hydroxocobalamin; parenteral
4.4
22.6
85
204
K92.1
ICD-10 Finland
Melaena
4.2
22.6
88
219
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
45.7
22.4
27
6
Z94.4
ICD-10 Finland
Liver transplant status
52.8
22.1
26
5
6419
FHL
Other measure in this category
223.1
21.6
22
*
K61.0
ICD-10 Finland
Anal abscess
6.3
21.6
58
95
J01DB01
ATC
cefalexin; oral
1.8
21.2
1219
10442
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.4
21.1
105
323
TJF80
NOMESCO Finland
Ostomy education
13.6
21.0
36
27
JFG50
NOMESCO Finland
Laparotomy with revision of enterostomy or colostomy
+∞
20.9
20
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
20.7
319
1807
E86
ICD-10 Finland
Volume depletion
6.7
20.7
53
82
C05AA08
ATC
fluocortolone; rectal, topical
2.2
20.3
222
1087
N02BE01
ATC
paracetamol; systemic, rectal
1.8
20.2
1242
10758
1490
FHL
Sigmoideoscopy (fiberscope)
36.3
19.9
25
7
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
36.3
19.9
25
7
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.1
19.8
263
1400
JHW96
NOMESCO Finland
Other operation on anus or perianal tissue
18.0
19.6
30
17
M05BA04
ATC
alendronic acid; oral
3.3
19.3
99
312
3005
Kela drug reimbursment
Tofacitinib
34.8
18.9
24
7
K62.8
ICD-10 Finland
Other specified diseases of anus and rectum
13.6
18.8
32
24
H02AB04
ATC
methylprednisolone; systemic
2.1
18.7
220
1110
JFA38
NOMESCO Finland
Endoscopic dilatation of small intestine
192.3
18.6
19
*
UJD02
NOMESCO Finland
Gastroscopy
3.6
18.5
84
240
UJF34
NOMESCO Finland
Left colonoscopy
15.3
18.5
30
20
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.3
18.2
188
895
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.9
18.1
117
430
JHD33
NOMESCO Finland
Completing incision of fistula-in-ano
53.2
18.0
21
*
N03AX16
ATC
pregabalin; oral
1.9
17.9
324
1931
K56.0
ICD-10 Finland
Paralytic ileus
12.1
17.8
32
27
JJC00
NOMESCO Finland
Allogenic transplantation of liver
67.4
17.7
20
*
K76.9
ICD-10 Finland
Liver disease, unspecified
7.6
17.7
41
55
JFA70
NOMESCO Finland
Suture of small intestine
29.2
17.4
23
8
ZXC86
NOMESCO Finland
Use of endoscopic device
17.2
17.4
27
16
A02BC03
ATC
lansoprazole; oral
1.8
17.3
381
2420
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
4.4
17.3
63
148
JAP00
NOMESCO Finland
Freeing of adhesions in the peritoneal cavity
8.5
16.7
36
43
5551A
ICD-9 Finland
Regional enteritis, Large intestine
+∞
16.7
16
*
5586X
ICD-9 Finland
Other non-infective gastro-enteritis and colitis[KROONINEN INFLAMMATOORINEN SUOLISTOSAIRAUS, NUD]
+∞
16.7
16
*
K91.4
ICD-10 Finland
Colostomy and enterostomy malfunction
35.5
16.7
21
6
A03CA02
ATC
clidinium and psycholeptics; oral
3.4
16.0
78
237
E0000UV
ATC
NA
1.6
15.8
547
3933
RD210
NOMESCO Finland
NA
5.3
15.8
48
93
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
10.5
15.7
30
29
JGB40
NOMESCO Finland
Excision of rectum and end ileostomy
+∞
15.6
15
*
56399
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Other
+∞
15.6
15
*
T81.8
ICD-10 Finland
Other complications of procedures, not elsewhere classified
5.8
15.6
44
78
JFH00
NOMESCO Finland
Total colectomy and ileorectal anastomosis
86.0
15.6
17
*
K83.9
ICD-10 Finland
Disease of biliary tract, unspecified
19.4
15.6
23
12
JWW96
NOMESCO Finland
Other reoperation in gastroenterological surgery
161.6
15.5
16
*
TPH07
NOMESCO Finland
Cathetrisation of artery
2.4
15.4
140
624
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.9
15.3
97
351
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.4
15.3
134
588
A07AA02
ATC
nystatin; oral
3.2
15.3
82
268
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
15.2
586
4318
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.4
15.2
133
580
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
15.2
272
1607
M13.9
ICD-10 Finland
Arthritis, unspecified
2.6
15.1
115
467
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.8
15.0
97
359
JAD30
NOMESCO Finland
Repair of incisional hernia using prosthetic material
6.6
15.0
38
59
UJF02
NOMESCO Finland
Peroral enteroscopy
15.2
14.9
24
16
WW200
NOMESCO Finland
Immunization
3.8
14.9
64
176
M07.4
ICD-10 Finland
Arthropathy in Crohn disease [regional enteritis]
+∞
14.6
14
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.8
14.5
257
1510
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.7
14.5
104
409
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
14.3
643
4898
0093A
ICD-9 Finland
Ill-defined intestinal infections, Diarrhoea of presumed infectious origin
6.2
14.3
38
63
B81
ICPC
Anaemia vit B12/folate deficiency
4.2
14.2
54
133
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.6
14.2
458
3213
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.3
14.1
135
620
JKE02
NOMESCO Finland
Transduodenal endoscopic incision of common bile duct orifice
7.6
13.9
32
43
D06BX01
ATC
metronidazole; topical
2.1
13.9
156
770
K83.8
ICD-10 Finland
Other specified diseases of biliary tract
53.8
13.8
16
*
WX110
NOMESCO Finland
Local anesthesy
1.5
13.7
1017
8638
K29.3
ICD-10 Finland
Chronic superficial gastritis
4.4
13.6
49
115
56300
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Regional enteritis
+∞
13.6
13
*
5761C
ICD-9 Finland
Other disorders of biliary tract, Cholangitis[CHOLANGITIS SCLEROSIVA]
+∞
13.6
13
*
D64.9
ICD-10 Finland
Anaemia, unspecified
2.5
13.5
106
440
R4110
NOMESCO Finland
Physiotherapy
1.7
13.4
345
2272
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.4
13.3
111
476
K85
ICD-10 Finland
Acute pancreatitis
6.2
13.2
35
58
D07AC01
ATC
betamethasone; topical
1.6
13.0
451
3209
JKE32
NOMESCO Finland
Endoscopic dilatation of bile duct
28.6
13.0
17
6
K62.4
ICD-10 Finland
Stenosis of anus and rectum
22.7
12.9
18
8
K83.1
ICD-10 Finland
Obstruction of bile duct
7.8
12.9
29
38
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
8.6
12.8
27
32
R11
ICD-10 Finland
Nausea and vomiting
2.4
12.7
113
501
D18
ICPC
Change in faeces/bowel movements
4.6
12.6
43
96
N02AJ06
ATC
codeine and paracetamol; systemic
1.5
12.6
520
3852
56902
ICD-8 Finland
Other diseases of intestines and peritoneum, Proctitis haemorrhagica (ulcerosa)
+∞
12.5
12
*
6410
FHL
Panprococolectomy and ileostomy
+∞
12.5
12
*
L04AA29
ATC
tofacitinib; oral
20.2
12.5
18
9
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
3.1
12.4
69
232
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
2.2
12.4
132
634
JF1AD
NOMESCO Finland
Small bowel CT
11.7
12.3
22
19
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.8
12.2
214
1249
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
37.9
12.2
15
*
R4190
NOMESCO Finland
Nutritional therapy
3.5
12.2
56
164
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
4.5
12.2
42
95
JA3BT
NOMESCO Finland
Cathetrisation of abdominal cavity with X-ray guidance
18.2
12.1
18
10
WX600
NOMESCO Finland
Single shot through catheter
4.1
12.0
46
115
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
6.9
11.9
29
43
A07AA11
ATC
rifaximin; oral
47.0
11.9
14
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.3
11.8
106
470
N11.9
ICD-10 Finland
Chronic tubulo-interstitial nephritis, unspecified
14.8
11.8
19
13
A02BA02
ATC
ranitidine; systemic
1.8
11.7
225
1355
K74.3
ICD-10 Finland
Primary biliary cirrhosis
12.6
11.6
20
16
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
3.5
11.6
54
160
K73.9
ICD-10 Finland
Chronic hepatitis, unspecified
19.1
11.6
17
9
JHD30
NOMESCO Finland
Incomplete incision of fistula-in-ano
19.1
11.6
17
9
J02AC01
ATC
fluconazole; systemic
1.5
11.6
546
4143
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
2.9
11.5
68
239
L04AA33
ATC
vedolizumab; parenteral
+∞
11.5
11
*
5552A
ICD-9 Finland
Regional enteritis, Small intestine with large intestine
+∞
11.5
11
*
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
15.2
11.3
18
12
K85.9
ICD-10 Finland
Acute pancreatitis, unspecified
4.7
11.2
37
80
J05AB11
ATC
valaciclovir; oral
1.9
11.1
173
968
S02.51
ICD-10 Finland
Fracture of tooth, open
2.0
11.0
148
783
K59.1
ICD-10 Finland
Functional diarrhoea
3.0
10.9
63
218
-44
ICPC
Preventive immunization/medic
2.3
10.8
105
485
6525
FHL
Enterostomy occlusion
60.4
10.6
12
*
JKD20
NOMESCO Finland
Anastomosis of bile duct to jejunum
60.4
10.6
12
*
WX306
NOMESCO Finland
Lumbar epidural anesthesy
2.2
10.6
109
518
Z98.0
ICD-10 Finland
Intestinal bypass and anastomosis status
11.3
10.6
19
17
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.4
10.5
49
146
JFA76
NOMESCO Finland
Closure of fistula of small intestine
110.8
10.4
11
*
JF1CM
NOMESCO Finland
Small bowel extensive MRI with with high intensity magnet
110.8
10.4
11
*
JF1DM
NOMESCO Finland
Very extensive MRI of small bowel (more than 1.5 T)
+∞
10.4
10
*
XF400
NOMESCO Finland
ECG with 12 standard connections
1.8
10.3
184
1080
JFK10
NOMESCO Finland
Freeing of adhesions in intestinal obstruction
18.9
10.3
15
8
UJH02
NOMESCO Finland
Anoscopy
2.7
10.2
66
247
S18
ICPC
Laceration/cut
1.5
10.1
513
3926
NA6BG
NOMESCO Finland
Sacro-iliac joint MRI examination with high intensity magnet
4.0
10.0
39
100
Z93.3
ICD-10 Finland
Colostomy status
9.2
10.0
20
22
SPAT1324
SPAT
Screening procedure
0.5
10.0
97
1750
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
6.1
10.0
26
43
JHD20
NOMESCO Finland
Incision of fistula-in-ano
5.8
10.0
27
47
JX1LA
NOMESCO Finland
Kinetic X-ray of alimentary tract with pictures
40.3
10.0
12
*
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
2.6
9.9
71
282
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.2
9.9
96
443
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.6
9.9
73
293
L88
ICD-10 Finland
Pyoderma gangrenosum
16.8
9.9
15
9
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
2.8
9.7
61
223
M45
ICD-10 Finland
Ankylosing spondylitis
3.3
9.7
47
145
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.0
9.7
124
648
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.3
9.6
89
404
XJW99
NOMESCO Finland
Other investigative procedure on digestive system
11.4
9.6
17
15
H20.1
ICD-10 Finland
Chronic iridocyclitis
5.5
9.5
27
50
R01AD12
ATC
fluticasone furoate; nasal
1.5
9.5
430
3209
M81.4
ICD-10 Finland
Drug-induced osteoporosis
17.6
9.4
14
8
JN4BD
NOMESCO Finland
Extensive body CT
2.0
9.4
124
655
K52.80
ICD-10 Finland
(Hemorrhagic) colitis caused by antibiotics
+∞
9.4
9
*
JWF00
NOMESCO Finland
Reoperation for insufficiency of anastomosis or suture in gastroenterological surgery
+∞
9.4
9
*
5550A
ICD-9 Finland
Regional enteritis, Small intestine
+∞
9.4
9
*
D50.8
ICD-10 Finland
Other iron deficiency anaemias
5.4
9.4
27
51
D07AC13
ATC
mometasone; topical
1.5
9.4
376
2730
JKE18
NOMESCO Finland
Endoscopic internal drainage of bile duct
8.1
9.3
20
25
OAB74
NOMESCO Finland
Nutritional guidance related to treatment and rehabilitation for medical condition
8.1
9.3
20
25
K43.0
ICD-10 Finland
Incisional hernia with obstruction, without gangrene
8.1
9.3
20
25
J01FA10
ATC
azithromycin; systemic
1.4
9.3
821
6937
J05AB01
ATC
aciclovir; systemic
1.6
9.2
267
1799
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.4
9.2
837
7104
K61.1
ICD-10 Finland
Rectal abscess
13.8
9.2
15
11
Z01.2
ICD-10 Finland
Dental examination
1.4
9.2
572
4537
M01AE01
ATC
ibuprofen; systemic, rectal
0.7
9.2
1148
12490
-1
SPAT
NA
2.7
9.1
61
231
S01FA04
ATC
cyclopentolate; ophthalmic
5.4
9.1
26
49
T81.3
ICD-10 Finland
Disruption of operation wound, not elsewhere classified
3.6
9.1
39
110
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
2.3
8.9
79
348
N05CF01
ATC
zopiclone; oral
1.5
8.9
376
2758
WW500
NOMESCO Finland
Blood transfusion
2.9
8.9
53
189
-69
ICPC
Other reason for encounter NEC
2.8
8.9
56
206
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.5
8.8
293
2038
JWA00
NOMESCO Finland
Repair of wound dehiscence in gastroenterological surgery
8.7
8.8
18
21
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.5
8.7
289
2010
JFF11
NOMESCO Finland
Laparoscopic loop enterostomy
14.1
8.7
14
10
JFB20
NOMESCO Finland
Ileocaecal resection
14.1
8.7
14
10
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.0
8.7
116
614
K91.8
ICD-10 Finland
Other postprocedural disorders of digestive system, not elsewhere classified
50.3
8.7
10
*
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
8.6
634
5159
WX723
NOMESCO Finland
CPAP therapy
2.6
8.6
60
236
M46.1
ICD-10 Finland
Sacroiliitis, not elsewhere classified
4.4
8.4
29
67
SAA02
NOMESCO Finland
Basic examination of mouth
1.4
8.4
928
8083
K63.2
ICD-10 Finland
Fistula of intestine
90.5
8.4
9
*
Z90.4
ICD-10 Finland
Acquired absence of other parts of digestive tract
90.5
8.4
9
*
JN1DM
NOMESCO Finland
Upper part of abdomen very extensive MRI examination with 3 Tesla magnet
90.5
8.4
9
*
B02.9
ICD-10 Finland
Zoster without complication
2.5
8.4
65
271
127
Kela drug reimbursment
Transplant complication
3.7
8.4
35
97
JFH31
NOMESCO Finland
Laparoscopic total colectomy, mucosal proctectomy and ileoanal anastomosis without ileostomy
+∞
8.3
8
*
5589X
ICD-9 Finland
Other non-infective gastro-enteritis and colitis, Other and unspecified non-infectious gastro-enteritis and colitis
+∞
8.3
8
*
4AC05
NOMESCO Finland
NA
+∞
8.3
8
*
D07AD01
ATC
clobetasol; topical
1.7
8.3
191
1209
K30
ICD-10 Finland
Functional dyspepsia
1.8
8.3
134
761
A01AB09
ATC
miconazole; local oral
2.0
8.3
97
490
J01DA01
ATC
[U] cefalexin; systemic
1.4
8.2
856
7375
R15
ICD-10 Finland
Faecal incontinence
3.9
8.2
32
84
M25.5
ICD-10 Finland
Pain in joint
1.5
8.1
362
2678
QBE15
NOMESCO Finland
Excision of other superficial lesion of skin of trunk
8.2
8.1
17
21
NA6AA
NOMESCO Finland
Sacro-iliac joint X-ray examination
8.2
8.1
17
21
JFK00
NOMESCO Finland
Division of adhesive band in intestinal obstruction
33.5
8.1
10
*
K55.9
ICD-10 Finland
Vascular disorder of intestine, unspecified
17.3
8.1
12
7
L04AA06
ATC
mycophenolic acid; systemic
3.3
8.1
38
116
J45.9
ICD-10 Finland
Asthma, unspecified
1.6
8.0
211
1385
5604
FHL
Vascular preparation or cannulation in the operating room
22.1
8.0
11
5
Z43.2
ICD-10 Finland
Attention to ileostomy
22.1
8.0
11
5
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
1.7
8.0
162
987
JG1JB
NOMESCO Finland
Defekography with X-ray
7.3
8.0
18
25
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
3.9
8.0
31
81
L40.0
ICD-10 Finland
Psoriasis vulgaris
2.4
7.9
65
280
SPAT1263
SPAT
Sampling
1.4
7.9
532
4249
N06AA09
ATC
amitriptyline; systemic
1.9
7.9
114
624
M81.9
ICD-10 Finland
Osteoporosis, unspecified
3.3
7.9
37
113
K80.3
ICD-10 Finland
Calculus of bile duct with cholangitis
8.5
7.8
16
19
S29
ICPC
Skin symptom/complaint other
1.6
7.7
197
1281
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
2.8
7.7
47
172
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
4.4
7.6
26
60
D07AB08
ATC
desonide; topical
1.8
7.6
139
821
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
11.9
7.6
13
11
TAB24
NOMESCO Finland
Implantation of epidural injection gate
25.1
7.6
10
*
D11
ICPC
Diarrhoea
1.7
7.5
153
934
D07XC01
ATC
betamethasone, combinations; topical
1.7
7.5
146
880
A02BA03
ATC
famotidine; systemic
2.9
7.5
44
157
R05
ICD-10 Finland
Cough
1.6
7.4
222
1499
WX419
NOMESCO Finland
Other general anesthesy
4.2
7.4
26
62
SPAT1125
SPAT
Stoma care and guidance
5.3
7.4
21
40
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
2.5
7.4
55
225
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
7.4
492
3913
D70.89
ICD-10 Finland
Neutropenic splenomegaly
4.7
7.3
23
49
K45.8
ICD-10 Finland
Other specified abdominal hernia without obstruction or gangrene
10.9
7.3
13
12
JFH01
NOMESCO Finland
Laparoscopic colectomy with ileorectal anastomosis
+∞
7.3
7
*
5563A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) proctosigmoiditis
+∞
7.3
7
*
M09.1*K50.9
ICD-10 Finland
Juvenile arthritis in Crohn's disease [regional enteritis]
+∞
7.3
7
*
K52.0
ICD-10 Finland
Gastroenteritis and colitis due to radiation
+∞
7.3
7
*
6408
FHL
Colectomy and ileostomy
+∞
7.3
7
*
A41.9
ICD-10 Finland
Sepsis, unspecified
2.8
7.3
43
154
RS221
NOMESCO Finland
NA
3.9
7.3
28
73
1300
FHL
Esophagogastroduodenoscopy (also includes staining)
6.3
7.2
18
29
TJG20
NOMESCO Finland
Transanal irrigation
15.8
7.2
11
7
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.5
7.2
55
229
K80.0
ICD-10 Finland
Calculus of gallbladder with acute cholecystitis
2.6
7.2
50
196
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
2.7
7.2
46
172
K75.4
ICD-10 Finland
Autoimmune hepatitis
20.1
7.1
10
5
K60.4
ICD-10 Finland
Rectal fistula
20.1
7.1
10
5
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.1
7.1
80
399
WX320
NOMESCO Finland
Spinalanesthesy
1.5
7.1
264
1874
R19.8
ICD-10 Finland
Other specified symptoms and signs involving the digestive system and abdomen
5.1
7.1
21
42
NG1DA
NOMESCO Finland
X-ray of knees
4.1
7.1
26
65
N02AA05
ATC
oxycodone; systemic
1.7
7.0
139
844
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.7
7.0
161
1018
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.8
7.0
126
741
SPAT1255
SPAT
Intravenous administration of medicine
2.0
6.9
80
403
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.8
6.9
113
644
K85.8
ICD-10 Finland
Other acute pancreatitis
7.6
6.9
15
20
SAD02
NOMESCO Finland
Assessment of need for oral health care, extensive
2.2
6.8
65
299
Z01.9
ICD-10 Finland
Special examination, unspecified
2.2
6.8
68
322
D07AB02
ATC
hydrocortisone butyrate; topical
1.4
6.8
345
2609
A04.9
ICD-10 Finland
Bacterial intestinal infection, unspecified
6.1
6.8
17
28
JH1CM
NOMESCO Finland
Perianal extensive MRI with 3 Tesla magnet
40.2
6.8
8
*
5781B
ICD-9 Finland
Gastro-intestinal haemorrhage, Melaena[HAEMORRHAGIA EX ANO]
40.2
6.8
8
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.7
6.8
131
790
J01FF01
ATC
clindamycin; systemic
1.4
6.7
329
2471
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.9
6.7
89
474
JHD96
NOMESCO Finland
Other incision of anal sphincter
22.6
6.7
9
*
L52
ICD-10 Finland
Erythema nodosum
6.5
6.6
16
25
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
3.1
6.6
33
107
JKE22
NOMESCO Finland
Endoscopic extraction of foreign body from bile duct
8.7
6.6
13
15
WX610
NOMESCO Finland
Patient controlled analgesia
4.8
6.5
20
42
B07.9
ICD-10 Finland
Verruca simplex
2.4
6.5
52
220
J01MA01
ATC
ofloxacin; systemic
1.9
6.5
95
524
J01AA02
ATC
doxycycline; systemic
1.3
6.5
1031
9300
M03BC51
ATC
orphenadrine, combinations; systemic
1.4
6.5
368
2838
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
2.0
6.5
81
422
1380
FHL
Colonoscopy, left side
70.1
6.4
7
*
K83
ICD-10 Finland
Other diseases of biliary tract
70.1
6.4
7
*
K73.0
ICD-10 Finland
Chronic persistent hepatitis, not elsewhere classified
70.1
6.4
7
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.4
6.4
423
3347
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.4
6.3
283
2088
XX3DW
NOMESCO Finland
Time consuming IT work
1.7
6.3
113
667
JFG70
NOMESCO Finland
Conversion of continent ileostomy to conventional ileostomy
+∞
6.3
6
*
6437
FHL
Rectum resection and sphincter-sparing through-anastomosis
+∞
6.3
6
*
E000003
ATC
NA
2.1
6.2
66
320
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
6.2
1000
9002
A06AC51
ATC
ispaghula, combinations; systemic
2.2
6.2
61
285
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.4
6.2
390
3053
JX1XE
NOMESCO Finland
Other ultrasound examinaton of alimentary organs
26.8
6.2
8
*
NH3EA
NOMESCO Finland
Feet X-ray examination with load
3.0
6.2
33
112
K02.1
ICD-10 Finland
Caries of dentine
1.3
6.2
818
7155
ZX114
NOMESCO Finland
Intramuscular
3.6
6.2
26
74
EAV
NOMESCO Finland
NA
3.3
6.2
29
90
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
2.8
6.2
36
129
JKA20
NOMESCO Finland
Cholecystectomy
3.0
6.1
33
113
S02.5
ICD-10 Finland
Fracture of tooth
2.7
6.1
40
153
R03AC02
ATC
salbutamol; inhalant
1.3
6.1
680
5807
SDE02
NOMESCO Finland
Periodontal treatment by dental hygienist
1.4
6.1
326
2483
E87.5
ICD-10 Finland
Hyperkalaemia
4.7
6.1
19
41
A03FA01
ATC
metoclopramide; systemic, rectal
1.5
6.1
229
1631
JN2CG
NOMESCO Finland
Extensive MRI examination of lower part of abdoment with high intensity magnet
3.7
6.1
24
65
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.3
6.0
50
219
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
2.3
6.0
52
231
L02.3
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of buttock
2.8
6.0
35
125
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
522
644
11.43
307.65
2.4
1.5
—
—
—
0
0
1347
4761
11.30
307.65
12.0
4.5
36.4
36.3
g/l
0.33
1319
4452
1217
1367
31.75
307.65
7.9
1.3
210.8
93.9
ug/g
16.01
1165
1045
340
352
11.93
303.75
1.8
1.5
0.7
0.1
iu/ml
1.23
72
57
1234
4964
7.02
291.79
4.3
2.1
74.5
74.3
nmol/l
0.06
1200
4544
1324
6013
7.27
262.00
16.0
5.7
2.9
2.8
%
0.32
1296
5629
264
242
12.81
254.37
4.5
3.4
3.8
4.2
e9/l
1.77
264
242
267
251
12.51
253.04
4.8
3.8
57.4
56.5
%
0.40
267
251
1373
6644
7.59
246.27
16.3
5.9
0.2
0.2
e9/l
0.44
1321
5886
1330
6278
6.95
244.83
16.1
5.7
28.4
28.8
%
0.55
1304
5887
1367
6615
7.45
244.34
16.2
5.6
1.8
2.0
e9/l
3.17
1323
5887
1317
6184
6.76
243.29
15.1
5.5
57.2
56.7
%
0.87
1293
5822
1240
5669
5.89
232.19
20.6
8.7
0.0
0.0
e9/l
1.12
1176
4666
827
2794
4.96
226.21
4.4
1.9
2.9
2.9
mg/l
0.04
766
2396
1399
7364
7.17
213.05
18.1
8.9
3.9
4.1
e9/l
3.39
1355
6462
169
124
15.08
185.02
1.2
1.1
—
—
—
0
0
1547
9600
12.01
177.24
21.5
6.8
77.5
76.3
u/l
0.51
1524
9056
212
247
9.71
170.85
3.6
7.2
517.8
386.4
iu/ml
0.20
27
39
395
1038
4.70
140.57
3.6
2.2
0.2
0.2
g/l
0.51
381
966
894
4425
3.25
119.26
6.0
3.3
30.4
31.7
u/l
0.77
791
4230
452
1467
3.87
119.08
3.1
2.5
22.1
24.4
%
2.48
428
1276
1416
9396
4.74
115.17
8.1
3.7
12.5
10.2
mm/h
8.27
1362
8796
115
104
11.82
110.12
2.5
1.1
—
—
—
0
0
102
88
12.29
100.58
2.8
1.4
—
—
—
0
0
447
1602
3.46
99.41
3.1
2.4
2.4
2.4
g/l
0.36
431
1492
469
1756
3.34
96.91
3.1
2.4
13.0
14.2
umol/l
2.51
451
1636
92
0
+∞
96.84
2.4
0.0
20.7
—
mg/l
—
86
0
92
0
+∞
96.84
2.4
0.0
—
—
—
0
0
101
96
11.15
93.40
1.6
1.1
302.0
187.1
titre
0.53
45
14
101
96
11.15
93.40
1.6
1.1
414.3
—
titre
—
7
0
324
979
3.88
92.80
3.0
2.6
11.9
10.4
g/l
9.50
304
897
1037
6292
2.77
84.22
10.3
6.1
11.0
11.3
umol/l
0.36
999
5973
177
368
5.27
81.51
6.4
3.4
45.8
3926.0
u/ml
0.81
160
314
976
5856
2.65
79.19
4.6
2.7
100.5
115.9
ug/l
0.67
920
5502
337
1155
3.41
78.84
3.7
2.4
37.9
81.0
u/l
0.53
310
993
138
246
6.03
74.95
1.5
1.2
—
—
—
0
0
336
1202
3.26
72.88
3.8
3.1
—
—
—
0
0
421
1790
2.82
66.60
2.4
1.6
1196.5
1187.0
nmol/l
0.06
234
1391
500
2333
2.65
65.76
3.0
1.6
9734941.7
40251052.6
pmol/l
1.27
452
1995
691
3801
2.41
63.35
4.3
2.5
60.3
56.9
u/l
0.87
671
3542
348
1406
2.87
60.00
5.6
2.7
6.6
7.9
umol/l
0.88
310
1225
820
4992
2.29
57.87
6.8
5.9
1.2
1.2
mmol/l
2.71
767
4560
79
111
7.43
53.68
1.1
1.2
52.2
57.1
u/l
0.32
66
73
863
5577
2.16
50.01
7.3
6.5
1.2
1.2
mmol/l
1.22
678
4737
1529
12703
4.06
49.66
26.8
10.4
89.0
87.7
ml/min/173m2
1.62
1441
10413
1438
11531
3.02
49.59
33.5
14.2
13.8
13.5
%
8.45
1429
11289
152
412
3.96
49.58
2.3
1.6
257.5
308.3
titre
—
8
12
266
1023
2.91
49.57
6.3
4.3
13.3
27.2
ug/l
0.54
201
832
75
109
7.16
49.43
1.9
1.5
10.5
11.6
umol/l
0.87
75
101
1577
13464
5.60
47.51
31.6
11.5
15.1
22.3
mg/l
27.79
1440
10430
90
167
5.64
46.63
1.2
1.3
—
—
—
0
0
116
273
4.50
45.59
1.2
1.2
345.0
248.5
u/ml
1.54
70
171
568
3211
2.18
45.38
3.5
2.9
0.6
0.4
e6/l
0.67
486
2387
237
904
2.90
44.59
4.5
3.7
1.2
1.2
mmol/l
2.15
212
782
577
3304
2.15
44.42
4.1
3.4
0.0
0.0
estimate
0.40
388
1165
97
203
5.02
43.93
6.5
3.9
72.9
290.4
u/ml
0.97
86
189
459
2410
2.26
43.81
2.8
2.5
6.8
6.1
e6/l
0.35
420
2126
115
289
4.20
41.47
1.1
1.2
—
—
—
0
0
273
1225
2.47
36.76
2.4
2.1
317.7
372.0
nmol/l
5.05
247
1144
53
74
7.37
36.15
1.6
1.5
6.5
6.9
u/l
0.05
38
29
150
499
3.21
35.60
1.2
1.4
—
—
—
0
0
57
91
6.45
34.36
1.1
1.0
—
—
—
0
0
45
57
8.09
33.33
23.5
27.4
136.4
122.9
ug/l
0.38
40
43
90
227
4.14
32.25
2.6
2.5
16.7
16.5
%
0.12
46
118
673
4449
1.87
31.85
2.3
1.8
93.6
96.4
pmol/l
0.92
424
2421
458
2679
1.99
31.29
2.0
1.4
2.8
2.3
g/l
5.70
334
1728
870
6268
1.83
30.83
4.6
4.3
0.0
0.0
estimate
0.50
398
1205
876
6331
1.82
30.66
3.7
3.2
0.0
0.0
estimate
0.80
389
1141
88
228
4.02
30.40
1.8
1.4
—
—
—
0
0
867
6264
1.82
30.20
3.7
3.1
0.0
0.0
estimate
0.80
391
1166
958
7160
1.81
29.54
6.2
4.6
6.5
6.6
mmol/l
0.52
911
6644
113
358
3.32
28.97
4.1
2.9
1.4
1.5
mg/l
0.34
105
332
344
1888
2.04
27.70
5.5
3.5
0.8
0.8
mmol/l
5.95
324
1787
414
2441
1.93
27.06
1.7
1.5
20.3
20.6
nmol/l
0.14
363
2134
119
415
3.01
25.94
1.8
1.8
—
—
—
0
0
212
991
2.31
25.54
9.6
8.3
8.6
8.8
mmol/l
0.17
205
954
279
1485
2.06
24.16
7.4
6.1
1.0
1.0
mmol/l
1.26
264
1394
73
208
3.63
22.04
2.3
2.8
180.0
1472.4
u/ml
—
5
14
1578
14490
3.43
21.69
26.3
9.0
27.3
28.1
u/l
1.35
1559
14069
680
4908
1.66
21.13
3.9
3.2
—
—
—
0
0
316
1837
1.89
20.97
2.8
2.6
2.0
2.4
e6/l
0.43
190
974
63
171
3.79
20.41
2.7
3.4
0.9
1.8
%
1.68
52
151
83
272
3.16
20.12
1.4
1.5
106.9
120.8
u/ml
0.33
12
56
320
1928
1.82
18.76
2.7
2.5
0.7
1.0
e6/l
2.13
196
1055
95
353
2.80
18.45
1.3
1.1
—
—
—
0
0
20
20
10.11
17.61
1.6
1.3
—
—
—
0
0
93
353
2.73
17.35
1.3
1.1
—
—
—
0
0
15
11
13.75
15.93
1.1
1.0
—
—
—
0
0
41
101
4.14
15.21
1.1
1.2
—
—
—
0
0
46
128
3.67
14.43
2.1
1.5
—
—
—
0
0
200
1124
1.89
14.41
3.8
2.8
1.9
1.8
%
0.72
182
1013
1475
13502
1.93
14.26
23.7
12.8
139.3
139.7
mmol/l
9.87
1437
13157
981
8154
1.51
14.13
4.8
3.8
52.2
1481.1
e6/l
1.25
13
106
46
132
3.56
13.81
2.2
1.4
—
—
—
0
0
46
132
3.56
13.81
2.2
1.4
—
—
—
0
0
1476
13552
1.90
13.58
24.0
12.9
3.9
4.0
mmol/l
7.48
1439
13182
71
268
2.72
13.42
5.0
3.4
31.4
35.4
umol/l
1.21
60
231
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
78
310
2.59
13.32
3.8
3.2
0.3
0.3
u/ml
0.62
49
164
29
62
4.74
12.85
1.1
1.2
60.9
27.6
u/l
0.32
23
47
206
1213
1.80
12.74
3.3
4.3
230.4
246.6
u/l
0.67
200
1160
22
37
6.01
12.60
1.3
1.4
—
—
—
0
0
59
209
2.89
12.57
1.1
1.1
—
—
—
0
0
43
130
3.37
11.95
2.2
1.5
—
—
—
0
0
746
6000
1.45
11.84
5.5
3.8
—
—
—
0
0
94
432
2.25
11.69
1.9
2.0
1.4
1.5
g/l
0.38
83
379
43
132
3.32
11.67
2.2
1.4
—
—
—
0
0
43
132
3.32
11.67
2.2
1.4
—
—
—
0
0
208
1261
1.74
11.60
16.5
17.7
1.3
1.2
inr
0.25
21
187
570
4413
1.45
10.83
3.4
3.1
51.4
42.9
ng/l
0.16
361
2681
62
245
2.59
10.76
2.6
2.3
131.2
131.5
g/l
0.03
52
181
78
350
2.29
10.29
2.0
1.7
—
—
—
0
0
503
3835
1.45
10.25
3.6
3.3
2.3
2.4
mmol/l
0.61
461
3447
1412
13009
1.62
10.14
26.6
12.2
40.3
40.8
%
1.68
1083
10288
161
942
1.79
10.13
6.2
3.6
1.2
1.9
mmol/l
1.62
127
759
65
274
2.43
9.88
3.1
2.2
38.1
38.2
g/l
0.02
60
243
121
656
1.91
9.70
1.6
1.5
—
—
—
0
0
38
122
3.16
9.64
2.5
1.4
0.8
1.0
g/l
3.28
38
122
415
3081
1.46
9.63
1.4
1.2
1.0
1.9
u/ml
2.54
96
875
33
97
3.45
9.62
2.5
3.4
57.2
51.5
%
0.74
22
74
73
333
2.25
9.29
2.9
2.2
3.0
3.1
g/l
0.77
62
264
68
305
2.28
9.01
3.0
2.3
0.7
0.8
g/l
0.13
63
277
70
320
2.24
8.87
2.9
2.2
12.2
10.5
g/l
2.04
62
282
254
1738
1.55
8.66
2.1
1.8
—
—
—
0
0
74
354
2.14
8.40
2.9
2.2
—
—
—
0
0
74
354
2.14
8.40
2.9
2.2
6.9
7.3
g/l
1.17
61
275
74
354
2.14
8.40
2.9
2.2
3.8
3.8
g/l
0.09
61
258
394
2965
1.43
8.35
3.2
2.1
—
—
—
0
0
19
43
4.46
7.90
1.4
1.4
—
—
—
0
0
19
44
4.36
7.69
1.4
1.4
—
—
—
0
0
37
134
2.80
7.67
3.0
2.4
32.9
32.5
pg
0.15
37
134
152
963
1.64
7.16
3.3
2.4
67.0
72.8
ml/min/173m2
0.93
71
367
382
2936
1.39
7.03
2.0
1.7
1.6
1.0
mg/l
1.87
289
2193
68
339
2.05
6.98
1.5
1.4
284.7
304.2
ug/g
0.29
45
191
103
594
1.78
6.84
1.8
1.6
—
—
—
0
0
17
41
4.18
6.55
1.5
1.4
—
—
—
0
0
17
41
4.18
6.55
1.5
1.4
—
—
—
0
0
20
55
3.67
6.48
1.1
1.1
—
—
—
0
0
132
829
1.64
6.45
2.3
2.6
68.2
67.2
g/l
0.75
126
772
1083
9769
1.32
6.42
5.6
3.0
56.6
46.0
u/l
3.41
1022
9283
1588
15367
2.09
6.41
41.8
17.1
272.8
253.4
e9/l
20.74
1573
15033
16
39
4.13
6.09
1.1
1.2
—
—
—
0
0
1588
15386
2.05
6.08
41.8
17.0
4.5
4.6
e12/l
20.74
1570
15024
1588
15392
2.04
5.97
41.9
17.1
6.8
6.7
e9/l
0.36
1572
15024
1588
15393
2.04
5.95
42.2
17.1
135.1
138.2
g/l
15.17
1577
15213
259
1913
1.42
5.93
3.8
2.9
2.5
2.4
mmol/l
1.62
233
1699
21
64
3.31
5.87
1.1
1.0
1493.8
1699.9
miu/ml
0.35
21
64
25
85
2.97
5.85
1.1
1.3
—
—
—
0
0
25
85
2.97
5.85
1.1
1.3
—
—
—
0
0
118
743
1.63
5.73
1.4
1.4
—
—
—
0
0
114
713
1.64
5.68
3.1
3.2
5.0
5.2
kpa
1.54
109
670
48
229
2.13
5.59
1.5
1.6
—
—
—
0
0
307
2360
1.37
5.53
1.3
1.3
21.8
28.6
iu/ml
0.69
89
724
109
679
1.65
5.52
3.1
3.3
1.3
1.6
mmol/l
0.42
78
504
170
1178
1.49
5.43
2.0
1.7
—
—
—
0
0
293
2247
1.37
5.35
1.3
1.3
7.2
11.1
u/ml
0.67
107
939
410
3309
1.32
5.32
2.9
2.4
1820.7
4668.7
umol/l
1.57
369
2953
25
90
2.81
5.31
1.9
1.8
—
—
—
0
0
32
132
2.45
5.22
1.9
2.0
—
—
—
0
0
42
198
2.15
5.06
1.7
1.9
—
—
—
0
0
35
153
2.32
5.05
1.5
1.3
—
—
—
0
0
1101
10101
1.27
4.94
3.4
3.3
—
—
—
0
0
169
1193
1.46
4.93
2.0
1.8
—
—
—
0
0
43
208
2.10
4.87
2.1
2.2
15.6
5.4
umol/l
1.38
29
151
21
73
2.90
4.77
1.3
1.2
—
—
—
0
0
35
161
2.20
4.51
1.8
1.8
—
—
—
0
0
52
285
1.85
4.18
3.4
3.5
42.3
32.5
mg/l
0.77
37
224
68
405
1.71
4.15
1.8
2.0
—
—
—
0
0
52
287
1.84
4.10
1.8
1.7
—
—
—
0
0
92
1383
0.65
4.07
8.1
5.7
—
—
—
0
0
361
2960
1.28
4.05
1.7
1.5
—
—
—
0
0
16
53
3.04
3.97
1.6
1.3
7.7
4.3
%
—
8
13
114
781
1.49
3.90
4.6
4.0
110.3
83.9
ng/l
1.16
106
706
51
285
1.81
3.88
3.5
3.5
51.6
75.2
mg/l
0.48
36
225
34
656
0.51
3.86
2.2
1.8
2.8
3.8
mg/l
0.75
21
456
6
5
12.04
3.76
1.0
1.0
—
—
—
0
0
18
66
2.75
3.76
1.1
1.8
—
772331.3
iu/ml
—
0
8
40
209
1.94
3.74
1.6
1.3
—
—
—
0
0
40
209
1.94
3.74
1.6
1.3
—
—
—
0
0
22
91
2.44
3.64
2.0
1.5
—
—
—
0
0
89
600
1.51
3.32
1.8
2.1
37.5
39.6
u/l
0.46
75
549
263
3211
0.78
3.23
3.5
3.6
20.0
21.0
%
0.43
113
1319
20
84
2.40
3.23
1.8
2.1
—
—
—
0
0
36
192
1.89
3.21
1.4
1.3
—
—
—
0
0
43
729
0.58
3.19
1.0
1.0
—
—
—
0
0
11
33
3.35
3.19
1.1
1.3
—
—
—
0
0
14
50
2.82
3.09
1.4
2.0
—
—
—
0
0
14
50
2.82
3.09
1.4
2.0
—
—
—
0
0
63
401
1.59
3.05
1.4
1.6
1.2
1.2
g/l
0.11
55
378
398
3400
1.23
3.04
1.8
1.6
1.5
1.4
mmol/l
1.06
316
2918
17
68
2.52
3.04
1.2
1.2
—
—
—
0
0
21
93
2.27
3.03
2.0
2.1
11.8
14.2
%
—
8
43
26
500
0.51
2.99
1.3
1.5
—
—
—
0
0
217
2687
0.78
2.98
3.6
3.4
1.0
1.0
kg/l
0.48
21
352
47
283
1.68
2.85
1.8
1.7
—
—
—
0
0
26
130
2.02
2.81
1.9
1.5
48.7
57.9
%
0.50
18
87
11
36
3.07
2.81
1.4
2.0
—
—
—
0
0
219
1765
1.28
2.80
3.2
2.2
31.1
29.6
s
2.07
211
1708
108
1456
0.72
2.71
3.7
4.0
32.2
31.1
%
0.42
85
1046
11
37
2.99
2.69
1.1
1.3
—
—
—
0
0
113
834
1.38
2.66
2.9
3.3
4.4
4.6
pmol/l
0.88
99
751
36
602
0.59
2.59
2.3
1.9
—
—
—
0
0
12
44
2.74
2.55
1.3
1.3
274.0
144.8
nmol/l
—
6
35
425
3717
1.19
2.50
3.5
3.3
8.4
8.2
mmol/l
0.40
354
3189
59
390
1.53
2.48
1.4
1.6
0.2
0.2
g/l
0.49
51
368
37
218
1.71
2.46
1.1
1.6
—
—
—
0
0
1251
13017
0.84
2.44
3.8
3.6
1.4
1.3
mmol/l
1.95
1152
12212
250
2080
1.24
2.44
1.9
1.9
1.4
1.4
%
0.03
208
1875
56
368
1.54
2.43
2.0
2.3
10.2
10.7
mg/l
0.17
49
342
5
158
0.31
2.42
1.0
1.0
—
—
—
0
0
21
103
2.05
2.42
1.3
1.1
—
—
—
0
0
1081
10211
1.17
2.42
3.9
3.8
14.7
14.6
pmol/l
0.65
989
9462
30
168
1.80
2.37
1.2
1.4
0.5
0.6
nmol/l
0.46
30
160
78
553
1.43
2.34
1.3
1.3
279.0
212.4
miu/ml
0.68
36
272
27
147
1.85
2.33
1.2
1.2
—
—
—
0
0
21
105
2.01
2.31
1.3
1.1
—
—
—
0
0
21
105
2.01
2.31
1.3
1.1
—
—
—
0
0
21
105
2.01
2.31
1.3
1.1
—
—
—
0
0
38
231
1.66
2.28
1.6
1.6
—
—
—
0
0
74
523
1.43
2.27
1.6
1.4
8.4
8.8
u/l
0.09
62
433
6
13
4.63
2.27
1.7
1.2
—
—
—
0
0
152
1206
1.29
2.23
7.5
8.4
0.1
1.1
mmol/l
1.61
117
946
9
29
3.11
2.22
1.1
1.1
90.7
96.7
%
—
9
29
9
29
3.11
2.22
1.1
1.1
—
—
—
0
0
108
818
1.34
2.21
1.5
1.3
22.8
25.1
iu/l
0.36
97
695
152
1209
1.28
2.19
7.5
8.4
4.9
5.1
kpa
3.04
144
1159
36
573
0.62
2.17
1.5
1.4
—
—
—
0
0
8
199
0.40
2.16
2.3
2.0
—
1088.0
—
0
10
16
74
2.17
2.15
1.8
1.7
—
—
—
0
0
52
347
1.51
2.14
2.2
3.0
—
—
—
0
0
1305
13486
0.84
2.09
4.1
3.9
1.5
1.4
mmol/l
1.17
1215
12687
151
1210
1.27
2.06
7.5
8.4
13.2
12.6
kpa
0.81
143
1163
20
103
1.95
2.05
1.3
1.1
—
—
—
0
0
24
132
1.83
2.04
1.0
1.1
—
—
—
0
0
7
178
0.39
2.02
1.1
1.1
—
—
—
0
0
14
64
2.20
1.94
1.9
1.8
—
—
—
0
0
27
157
1.73
1.93
1.5
1.6
—
—
—
0
0
135
1677
0.79
1.93
1.3
1.7
—
—
—
0
0
7
172
0.40
1.91
1.1
1.1
—
—
—
0
0
20
107
1.88
1.86
2.1
1.4
39.3
35.7
%
0.16
14
71
254
2179
1.20
1.85
3.4
3.3
233.6
529.8
ng/l
1.75
174
1498
13
59
2.21
1.84
1.7
1.6
—
—
—
0
0
13
59
2.21
1.84
1.7
1.6
—
—
—
0
0
13
59
2.21
1.84
1.7
1.6
—
—
—
0
0
13
59
2.21
1.84
1.7
1.6
—
—
—
0
0
24
138
1.75
1.80
2.9
2.9
1.0
0.9
nmol/l
0.29
18
102
27
161
1.69
1.78
1.9
1.8
—
—
—
0
0
42
286
1.48
1.63
1.2
1.2
79.3
41.1
u/ml
—
5
24
66
490
1.36
1.60
1.7
1.7
—
—
—
0
0
10
43
2.33
1.60
7.5
4.7
—
—
—
0
0
13
63
2.07
1.60
2.6
3.6
604.6
1128.9
u/ml
0.74
13
63
36
528
0.67
1.55
1.7
1.5
—
—
—
0
0
13
64
2.04
1.54
1.9
1.8
—
—
—
0
0
10
44
2.28
1.53
2.9
2.7
—
—
—
0
0
6
144
0.41
1.51
5.0
13.9
753.3
799.9
nmol/l
—
6
138
1337
13715
0.86
1.51
4.4
4.3
2.7
2.9
mmol/l
5.92
1234
12877
22
131
1.69
1.49
1.1
1.7
—
—
—
0
0
205
2369
0.85
1.46
2.8
2.7
0.6
0.7
ug/l
0.76
130
1384
33
484
0.68
1.44
1.6
1.4
—
—
—
0
0
33
483
0.68
1.43
1.6
1.4
—
—
—
0
0
42
296
1.43
1.40
1.2
1.3
—
—
—
0
0
379
3433
1.14
1.37
4.8
4.1
6.1
9.5
mg/mmol
1.52
248
2234
34
485
0.69
1.31
1.6
1.4
—
—
—
0
0
6
24
2.51
1.30
1.0
1.3
—
—
—
0
0
307
2753
1.14
1.30
2.7
3.0
1192.4
1074.4
ng/l
0.22
254
2283
34
484
0.70
1.29
1.6
1.4
—
—
—
0
0
1254
12885
0.89
1.29
4.0
4.0
5.8
5.8
mmol/l
0.17
1137
11977
5
18
2.78
1.28
3.2
1.4
—
—
—
0
0
56
424
1.33
1.25
1.3
1.3
—
—
—
0
0
46
338
1.37
1.24
1.2
1.3
17.8
8.0
u/ml
—
8
56
45
330
1.37
1.23
1.2
1.3
21.1
2.5
u/ml
—
6
36
31
213
1.46
1.21
1.8
1.7
—
—
—
0
0
384
3511
1.12
1.19
2.2
2.1
222.2
247.5
u/l
0.18
360
3327
16
94
1.71
1.17
1.9
2.0
—
—
—
0
0
26
174
1.50
1.15
1.1
1.1
96.6
97.1
%
0.03
26
164
5
20
2.50
1.15
2.8
1.3
0.3
0.4
ug/l
—
5
11
5
20
2.50
1.15
1.4
1.7
—
—
—
0
0
70
873
0.79
1.12
2.1
2.2
9.5
8.0
ug/l
0.27
64
789
33
236
1.41
1.07
1.0
1.1
—
—
—
0
0
17
105
1.63
1.06
4.2
3.9
—
—
—
0
0
17
105
1.63
1.06
2.9
2.3
799.1
733.2
e6/l
—
10
43
1327
13549
0.89
1.05
4.3
4.0
4.7
4.7
mmol/l
2.58
1238
12812
27
187
1.45
1.04
1.8
1.5
—
—
—
0
0
13
215
0.60
1.03
1.5
1.1
—
—
—
0
0
10
53
1.89
1.01
1.1
4.0
56.0
115.1
umol/l
—
5
28
7
35
2.00
1.00
1.1
1.1
—
—
—
0
0
16
99
1.62
1.00
1.6
1.5
—
—
—
0
0
16
99
1.62
1.00
1.6
1.5
—
—
—
0
0
16
99
1.62
1.00
1.6
1.5
—
—
—
0
0
37
275
1.35
0.97
1.8
1.4
0.5
0.4
nmol/l
0.45
28
218
146
1271
1.16
0.97
2.3
2.2
12.1
13.4
nmol/l
1.32
134
1155
82
679
1.22
0.95
3.0
2.2
13127.7
4589.9
u/l
0.50
27
266
17
258
0.66
0.95
5.7
3.5
22.1
27.9
mg/l
—
9
158
17
109
1.57
0.93
1.6
1.8
—
—
—
0
0
6
28
2.15
0.91
1.7
1.6
—
—
—
0
0
25
177
1.42
0.88
1.1
1.1
—
—
—
0
0
32
425
0.75
0.87
1.6
1.5
—
—
—
0
0
6
31
1.94
0.84
1.8
2.3
—
—
—
0
0
6
31
1.94
0.84
1.8
2.3
—
—
—
0
0
15
96
1.57
0.84
1.2
1.1
—
—
—
0
0
49
391
1.26
0.81
2.5
2.5
245.7
402.3
ug/l
0.86
43
368
14
89
1.58
0.81
1.7
2.0
—
—
—
0
0
8
47
1.71
0.80
1.4
1.7
—
—
—
0
0
8
47
1.71
0.80
1.4
1.7
—
—
—
0
0
18
122
1.48
0.80
2.6
2.2
41.5
24.2
mg/l
—
8
35
1249
12226
1.09
0.79
4.5
4.4
1.7
2.2
mu/l
1.72
1161
11401
0
25
0.00
0.79
0.0
1.2
—
—
—
0
0
8
48
1.67
0.78
1.5
1.7
—
—
—
0
0
0
27
0.00
0.77
0.0
3.0
—
—
—
0
0
31
235
1.33
0.76
1.6
1.2
2.8
3.5
u/ml
0.21
20
70
5
25
2.00
0.72
1.0
1.3
-0.5
2.3
mmol/l
—
5
25
13
195
0.66
0.72
2.7
2.9
6.0
7.3
mmol/l
1.63
13
190
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
5
26
1.93
0.70
1.4
1.0
—
82.6
—
0
5
252
2324
1.10
0.70
1.5
1.5
—
—
—
0
0
49
400
1.23
0.70
1.2
1.1
—
—
—
0
0
17
118
1.45
0.69
1.2
1.7
—
—
—
0
0
5
27
1.85
0.68
1.4
1.1
—
87.5
—
0
6
56
466
1.21
0.67
3.7
2.5
0.7
0.7
%
0.16
56
453
1188
12117
0.93
0.67
5.3
4.9
38.6
38.9
mmol/mol
0.55
1109
11408
7
43
1.63
0.67
1.9
1.9
—
—
—
0
0
7
44
1.59
0.65
1.7
2.5
—
—
—
0
0
10
62
1.62
0.65
1.1
1.0
190.8
210.8
iu/ml
—
10
62
109
1225
0.88
0.61
1.8
2.0
—
—
—
0
0
38
307
1.24
0.61
1.7
1.3
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
207
2242
0.91
0.60
2.0
2.1
—
—
—
0
0
6
35
1.72
0.57
1.3
1.3
12.9
8.6
ug/l
—
6
35
27
217
1.25
0.48
1.1
1.1
—
—
—
0
0
54
466
1.16
0.47
2.2
1.8
—
—
—
0
0
16
120
1.34
0.46
1.0
1.1
—
—
—
0
0
5
83
0.60
0.45
3.4
7.8
—
126.7
—
0
29
29
237
1.23
0.45
1.6
1.2
3.1
5.4
u/ml
0.84
22
98
16
208
0.77
0.44
1.4
1.3
7.9
7.2
mmol/l
0.33
11
145
189
2021
0.93
0.43
2.0
2.0
—
—
—
0
0
0
15
0.00
0.41
0.0
2.1
—
—
—
0
0
8
59
1.36
0.41
1.1
1.0
—
—
—
0
0
86
949
0.90
0.40
1.5
1.9
—
—
—
0
0
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
29
243
1.20
0.37
1.1
1.1
—
—
—
0
0
56
496
1.13
0.37
1.6
1.5
—
—
—
0
0
17
213
0.80
0.37
2.5
2.8
1.2
1.5
mmol/l
1.36
17
204
9
124
0.72
0.35
1.0
1.1
—
—
—
0
0
47
419
1.13
0.30
2.2
1.7
—
—
—
0
0
7
55
1.27
0.30
2.4
3.3
—
—
—
0
0
13
102
1.28
0.30
1.1
1.6
—
—
—
0
0
83
893
0.93
0.26
1.6
1.5
—
—
—
0
0
392
4032
0.96
0.25
4.1
4.1
1.9
2.1
ug/l
0.88
357
3664
40
359
1.12
0.24
1.7
1.9
3.8
4.7
iu/l
0.35
20
129
6
85
0.70
0.24
1.2
1.2
—
—
—
0
0
44
399
1.11
0.23
1.1
1.1
13.4
4.4
u/ml
—
5
66
16
134
1.20
0.23
5.6
4.5
12.7
116.2
u/ml
—
6
40
83
885
0.93
0.22
1.2
1.3
52.1
44.0
au/ml
—
5
43
91
967
0.94
0.22
2.1
2.4
36.2
24.2
au/ml
—
7
72
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
2.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
6
49
1.23
0.20
1.2
1.1
—
—
—
0
0
31
342
0.90
0.18
1.1
1.1
0.3
1.9
u/ml
2.38
12
142
73
689
1.06
0.17
1.8
1.6
292.6
288.9
mu/l
0.05
64
627
10
82
1.22
0.17
1.0
1.1
—
12.7
u/ml
—
0
6
8
70
1.14
0.16
1.0
1.5
—
67.3
%
—
0
11
35
378
0.92
0.14
1.9
1.7
—
—
—
0
0
10
118
0.85
0.14
1.3
1.5
—
—
—
0
0
9
106
0.85
0.13
1.1
1.5
2.1
1.9
mmol/l
—
9
99
99
1027
0.96
0.12
1.2
1.2
108.0
138.2
iu/ml
0.52
29
406
32
344
0.93
0.12
1.1
1.3
486.1
518.7
mg/l
0.12
32
324
12
105
1.14
0.11
1.1
2.4
—
—
—
0
0
33
309
1.07
0.10
1.4
1.5
—
—
—
0
0
24
224
1.07
0.08
1.3
1.5
—
—
—
0
0
7
66
1.06
0.08
1.1
2.1
—
—
—
0
0
7
82
0.85
0.07
1.3
1.6
—
—
—
0
0
7
83
0.84
0.07
1.0
1.5
5.3
6.7
u/l
—
7
67
11
122
0.90
0.07
1.2
1.9
—
—
—
0
0
9
87
1.03
0.07
1.2
1.2
—
1.8
—
0
5
10
111
0.90
0.06
1.7
1.1
—
—
—
0
0
29
276
1.05
0.06
1.7
1.6
6196.7
9952.6
e6/l
0.60
22
208
10
90
1.11
0.05
1.4
1.3
—
—
—
0
0
15
139
1.08
0.05
1.4
1.1
—
—
—
0
0
13
140
0.93
0.04
1.4
1.5
8.8
13.4
mmol/l
—
6
33
78
766
1.02
0.03
2.4
2.8
217.3
159.6
ng/l
0.35
68
681
24
230
1.04
0.03
1.1
1.1
41.0
2100.1
iu/ml
—
6
63
30
293
1.02
0.01
3.0
2.4
41.1
136.3
ug/min
2.27
20
183
23
236
0.97
0.00
1.1
1.1
1.1
2.6
u/ml
—
6
115
12
116
1.03
0.00
3.6
1.6
1.1
1.4
promille
—
7
95
30
301
1.00
0.00
1.1
1.5
53.8
2253.4
e6/l
1.38
24
244
30
301
1.00
0.00
1.0
1.4
22.3
18.9
e6/l
0.09
22
235
25
255
0.98
0.00
1.8
1.7
—
—
—
0
0
10
105
0.95
0.00
3.1
2.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
1765.2
—
0
5
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
4.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
2.4
—
0
6
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
5.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
55
0.91
0.00
1.4
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
5.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
9
94
0.96
0.00
1.2
1.2
—
73.9
—
0
8
9
92
0.98
0.00
1.2
1.1
—
43.2
—
0
5
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
7
72
0.97
0.00
1.3
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint ULCERILEO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ULCERILEO | 1.556 [1.35, 1.8] | < 0.001 |
| Birth year | 0.994 [0.98, 1.0] | 0.237 |
During the follow-up period (1.1.1998 — 31.12.2019), 348 out of 3374 females with ULCERILEO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ULCERILEO | 1.401 [1.24, 1.58] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 558 out of 4020 males with ULCERILEO died.
Mortality risk
Mortality risk for people of age
years, who have ULCERILEO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.146% | 0.272% |
| 5 | 0.768% | 1.692% |
| 10 | 2.104% | 4.381% |
| 15 | 4.226% | 8.036% |
| 20 | 7.32% | 12.983% |
Relationships between endpoints
↥Index endpoint: ULCERILEO – Ulcerative ileocolitis
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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