mononeuropathy: Disease or trauma involving a single peripheral nerve in isolation, or out of proportion to evidence of diffuse peripheral nerve dysfunction. Mononeuropathy multiplex refers to a condition characterized by multiple isolated nerve injuries. Mononeuropathies may result from a wide variety of causes, including ischemia; traumatic injury; compression; connective tissue diseases; cumulative trauma disorders; and other conditions.
Other and unspecified mononeuropathies of lower limb
DOID EFO Endpoint Browser PheWeb
G6_MONOLOWOTHUNS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1033 |
4. Check minimum number of eventsNone |
1033 |
5. Include endpointsNone |
1033 |
6. Filter based on genotype QC (FinnGen only) |
1033 |
Control definitions (FinnGen only)
- Control exclude
- G6_NERPLEX
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified mononeuropathies of lower limb
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6122 | 3829 | 2260 |
| Only index persons | 5614 | 3606 | 2008 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.11 | 0.06 |
| Only index persons | 0.11 | 0.13 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 51.76 | 52.07 | 51.23 |
| Only index persons | 50.93 | 51.59 | 49.75 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1033 | 708 | 325 |
| Unadjusted period prevalence (%) | 0.21 | 0.24 | 0.14 |
| Median age at first event (years) | 52.58 | 51.90 | 54.06 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 942
- Matched controls
- 9420
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G57.8
ICD-10 Finland
Other mononeuropathies of lower limb
3731.5
323.0
513
*
G57.9
ICD-10 Finland
Mononeuropathy of lower limb, unspecified
1789.5
282.0
260
*
ACC19
NOMESCO Finland
Transcision of peripheral nerve: other or unspecified
2227.6
185.8
174
*
3557X
ICD-9 Finland
Mononeuritis of lower limb, Other mononeuritis of lower limb
+∞
172.3
160
*
G57.6
ICD-10 Finland
Lesion of plantar nerve
52.8
110.4
132
29
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
77.6
97.9
110
16
N03AX16
ATC
pregabalin; oral
4.9
94.0
397
1229
G56.0
ICD-10 Finland
Carpal tunnel syndrome
16.8
90.1
148
103
N03AX12
ATC
gabapentin; oral
5.4
81.1
282
686
9273
FHL
Other surgery for toe deformity or pain condition, e.g., Morton, hammer toe
47.3
77.2
94
22
ACC51
NOMESCO Finland
Release of median nerve
82.7
61.9
69
9
M77.4
ICD-10 Finland
Metatarsalgia
7.8
60.7
149
222
N02AX02
ATC
tramadol; systemic, rectal
3.1
58.9
516
2638
M79.6
ICD-10 Finland
Pain in limb
3.1
57.9
462
2206
2402
FHL
External neurolysis of the nerve and possible alteration of the pathway (nerve pressure)
76.0
56.9
64
9
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
4.0
45.9
208
621
M25.5
ICD-10 Finland
Pain in joint
3.0
45.4
353
1587
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.7
45.0
517
2945
N06AA09
ATC
amitriptyline; systemic
4.3
44.2
181
490
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.1
44.0
192
552
M01AH05
ATC
etoricoxib; oral
2.6
41.3
634
4167
M19.0
ICD-10 Finland
Primary arthrosis of other joints
4.4
38.5
153
399
G57.3
ICD-10 Finland
Lesion of lateral popliteal nerve
52.4
37.9
45
9
XA402
NOMESCO Finland
ENMG
11.4
37.2
71
67
A02BC05
ATC
esomeprazole; systemic
2.4
35.8
463
2689
M01AB05
ATC
diclofenac; systemic, rectal
2.5
35.0
686
4893
ACB19
NOMESCO Finland
Excision of lesion of peripheral nerve other or unspecified
181.5
34.0
35
*
M54.5
ICD-10 Finland
Low back pain
2.5
33.5
369
1952
M03BX02
ATC
tizanidine; oral
2.3
32.6
643
4509
M54.4
ICD-10 Finland
Lumbago with sciatica
3.1
32.3
204
770
M17.1
ICD-10 Finland
Other primary gonarthrosis
2.7
31.6
256
1131
N02AJ06
ATC
codeine and paracetamol; systemic
2.3
31.2
390
2177
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.8
30.7
144
432
M20.4
ICD-10 Finland
Other hammer toe(s) (acquired)
5.5
30.6
95
189
3558X
ICD-9 Finland
Mononeuritis of lower limb, unspecified
+∞
30.4
29
*
M01AE03
ATC
ketoprofen; systemic, rectal
2.3
30.1
410
2377
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.6
29.3
269
1271
M01AC06
ATC
meloxicam; systemic, rectal
2.2
29.2
410
2403
N06AX21
ATC
duloxetine; oral
3.5
29.0
146
464
M01AE02
ATC
naproxen; oral, rectal
2.2
28.6
573
3924
N02BE01
ATC
paracetamol; systemic, rectal
2.9
28.0
842
6993
ZXA00
NOMESCO Finland
Right side
2.4
27.1
297
1527
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.6
27.1
130
396
ABD30
NOMESCO Finland
Implantation of spinal stimulation device
25.6
26.7
37
15
M02AA07
ATC
piroxicam; topical
2.1
26.0
405
2447
L17
ICPC
Foot/toe symptom/complaint
2.3
25.9
286
1474
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
3.8
24.3
108
308
R52.2
ICD-10 Finland
Other chronic pain
6.6
24.1
63
101
M20.1
ICD-10 Finland
Hallux valgus (acquired)
3.3
24.1
132
443
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
7.6
22.8
54
75
M70.6
ICD-10 Finland
Trochanteric bursitis
2.8
22.5
161
646
A02BC03
ATC
lansoprazole; oral
2.1
21.8
320
1851
M01AH01
ATC
celecoxib; oral (coxibs)
2.4
21.5
222
1091
M01AX17
ATC
nimesulide; oral
2.2
21.4
274
1490
M48.0
ICD-10 Finland
Spinal stenosis
2.9
21.1
138
524
R51.80
ICD-10 Finland
Headache
2.7
21.0
165
697
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
7.7
20.9
49
67
G57.0
ICD-10 Finland
Lesion of sciatic nerve
78.6
20.8
23
*
S18
ICPC
Laceration/cut
2.0
20.7
410
2655
A02BC02
ATC
pantoprazole; systemic
1.9
20.3
637
4875
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.4
20.1
197
937
ZXA05
NOMESCO Finland
Left side
2.1
20.1
269
1487
M03BC01
ATC
orphenadrine (citrate); systemic
2.2
20.0
247
1316
M89.0
ICD-10 Finland
Algoneurodystrophy
22.1
19.6
28
13
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
19.5
301
1758
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
19.5
353
2196
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
2.7
19.4
144
588
M01AH02
ATC
rofecoxib; oral
2.6
19.2
155
665
M54.1
ICD-10 Finland
Radiculopathy
5.6
19.2
57
108
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
18.7
19.2
29
16
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
19.2
427
2861
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
4.4
18.9
71
173
A02BA02
ATC
ranitidine; systemic
2.2
18.6
213
1092
L15
ICPC
Knee symptom/complaint
2.2
18.5
222
1160
M02AA10
ATC
ketoprofen; topical
2.3
18.2
186
903
N03AE01
ATC
clonazepam; systemic
3.9
18.1
76
206
J01DB01
ATC
cefalexin; oral
2.1
18.0
768
6419
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
2.4
17.2
159
732
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
5.1
17.2
55
114
R20.2
ICD-10 Finland
Paraesthesia of skin
3.5
16.9
83
256
J01MA02
ATC
ciprofloxacin; systemic
1.8
16.8
373
2465
N06AX16
ATC
venlafaxine; oral
2.5
16.7
148
664
9271
FHL
Hallux surgery
6.0
16.7
46
80
M72.2
ICD-10 Finland
Plantar fascial fibromatosis
3.0
16.6
99
351
2401
FHL
Nerve exploration (includes biopsy and removal of local change)
91.7
16.6
18
*
L03
ICPC
Low back symptom/complaint
2.0
16.6
238
1336
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.6
16.6
132
561
M79.0
ICD-10 Finland
Rheumatism, unspecified
4.3
16.2
61
150
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
3.4
16.2
82
260
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
16.0
221
1218
M54.6
ICD-10 Finland
Pain in thoracic spine
3.4
15.8
80
253
3540A
ICD-9 Finland
Mononeuritis of upper limb and mononeuritis multiplex, Carpal tunnel syndrome
+∞
15.7
15
*
Z50.1
ICD-10 Finland
Other physical therapy
3.6
15.7
71
206
R07.4
ICD-10 Finland
Chest pain, unspecified
1.9
15.7
270
1621
L13
ICPC
Hip symptom/complaint
2.2
15.6
177
895
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
3.8
15.5
66
182
WX320
NOMESCO Finland
Spinalanesthesy
2.0
15.4
234
1338
H02AB06
ATC
prednisolone; systemic
1.8
15.3
437
3104
N02AA05
ATC
oxycodone; systemic
2.3
15.2
156
754
SPAT1153
SPAT
Removal of sutures
1.9
15.2
307
1948
X58
ICD-10 Finland
Exposure to other specified factors
2.4
15.2
134
601
ABD32
NOMESCO Finland
Implantation of temporary spinal stimulation device
23.8
15.1
21
9
G56.2
ICD-10 Finland
Lesion of ulnar nerve
14.2
15.1
25
18
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
3.4
15.1
74
229
NHL68
NOMESCO Finland
Tenodesis, shortening or lengthening of tendon of foot
8.7
15.1
32
38
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.2
14.9
174
891
J02AC01
ATC
fluconazole; systemic
1.8
14.8
404
2818
N05CF01
ATC
zopiclone; oral
1.8
14.7
320
2077
L08
ICPC
Shoulder symptom/complaint
2.1
14.7
194
1046
9476
FHL
Splitting of fascia or aponeurosis
15.7
14.4
23
15
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.7
14.4
445
3213
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
3.1
14.4
82
282
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.0
14.4
207
1156
N06AA10
ATC
nortriptyline; systemic
5.8
14.3
40
71
NHK30
NOMESCO Finland
Osteotomy or rotation osteotomy of first metatarsal or tarsal bone
3.7
14.3
64
184
M01AX01
ATC
nabumetone; oral
3.9
14.1
58
155
H02BX01
ATC
methylprednisolone, combinations; systemic
3.4
14.1
70
219
G57.1
ICD-10 Finland
Meralgia paraesthetica
10.3
14.0
27
27
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
4.6
14.0
48
108
N03AX09
ATC
lamotrigine; oral
3.8
13.9
60
167
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
4.7
13.9
47
104
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.1
13.9
79
272
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.8
13.9
280
1764
NHK40
NOMESCO Finland
Osteotomy or rotation osteotomy of II-V metatarsal or tarsal bone
5.9
13.7
38
67
R03AC02
ATC
salbutamol; inhalant
1.7
13.7
485
3628
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.5
13.7
114
495
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.9
13.7
87
322
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.3
13.7
131
609
G57.5
ICD-10 Finland
Tarsal tunnel syndrome
76.2
13.6
15
*
J01DA01
ATC
[U] cefalexin; systemic
1.7
13.6
577
4542
M01AX05
ATC
glucosamine; oral
1.9
13.6
216
1250
J01FF01
ATC
clindamycin; systemic
1.8
13.6
263
1631
G56.4
ICD-10 Finland
Causalgia
+∞
13.6
13
*
M01AE01
ATC
ibuprofen; systemic, rectal
2.1
13.5
832
7382
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.4
13.5
116
513
AEA00
NOMESCO Finland
Replacement of impulse generator of stimulation device in the nervous system
26.2
13.4
18
7
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
3.0
13.3
81
291
M03BC51
ATC
orphenadrine, combinations; systemic
1.8
13.3
277
1759
M54.3
ICD-10 Finland
Sciatica
3.2
13.3
71
235
N06AX11
ATC
mirtazapine; oral
1.8
13.3
309
2035
X59
ICD-10 Finland
Exposure to unspecified factor
2.1
13.2
176
947
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
2.3
13.2
124
573
M79.1
ICD-10 Finland
Myalgia
2.2
12.8
135
656
J01AA02
ATC
doxycycline; systemic
1.8
12.8
737
6286
7354A
ICD-9 Finland
Acquired deformities of toe, Other hammer toe (acquired)
14.3
12.8
21
15
G44.2
ICD-10 Finland
Tension-type headache
2.2
12.8
139
685
A02BC01
ATC
omeprazole; systemic
1.8
12.7
258
1621
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
7.2
12.6
30
43
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
4.8
12.5
41
88
A06AC01
ATC
ispaghula (psylla seeds); oral
1.8
12.5
244
1511
J45.9
ICD-10 Finland
Asthma, unspecified
2.0
12.5
177
978
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
12.3
253
1592
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.5
12.3
100
429
R06.0
ICD-10 Finland
Dyspnoea
1.8
12.3
236
1455
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
12.2
448
3343
A03FA02
ATC
cisapride; oral, rectal
2.7
12.2
87
347
Z00.0
ICD-10 Finland
General medical examination
2.0
12.1
174
965
NH1CG
NOMESCO Finland
Ankle and foot extensive MRI examination with high intensity magnet
7.4
12.1
28
39
7350A
ICD-9 Finland
Acquired deformities of toe, Hallux valgus (acquired)
5.3
12.1
36
70
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.3
12.0
112
515
M20.2
ICD-10 Finland
Hallux rigidus
4.2
12.0
45
111
7227C
ICD-9 Finland
Intervertebral disk disorders, Intervertebral disk disorder with myelopathy[SYNDROMA ISCHIADICUM]
4.2
12.0
45
111
M01AB55
ATC
diclofenac, combinations; oral
2.8
12.0
79
301
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.8
11.9
277
1810
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
3.3
11.9
59
185
M54.2
ICD-10 Finland
Cervicalgia
2.9
11.9
72
258
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.6
11.8
85
340
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
2.5
11.8
97
419
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.7
11.7
81
317
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.7
11.7
364
2590
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.7
11.7
81
318
R01AD09
ATC
mometasone; nasal
1.6
11.7
413
3042
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
3.2
11.6
62
205
NDM40
NOMESCO Finland
Discission of sheath of tendon of wrist or hand
5.2
11.6
35
69
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
4.0
11.6
46
120
R05FA02
ATC
opium derivatives and expectorants; systemic
1.6
11.6
386
2795
35399
ICD-8 Finland
Sciatica
+∞
11.5
11
*
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
3.8
11.4
47
127
Z03.8
ICD-10 Finland
Observation for other suspected diseases and conditions
3.3
11.4
58
186
M77.1
ICD-10 Finland
Lateral epicondylitis
2.8
11.1
70
259
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.3
11.1
105
485
L28
ICPC
Limited function/disability (L)
2.0
11.0
157
867
S29
ICPC
Skin symptom/complaint other
2.0
11.0
162
904
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.6
11.0
362
2605
R52.9
ICD-10 Finland
Pain, unspecified
2.5
10.9
88
374
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
2.5
10.9
86
363
R35
ICD-10 Finland
Polyuria
2.9
10.9
67
243
1220
FHL
Arthroscopy
3.3
10.8
53
165
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
3.7
10.8
46
128
NHG70
NOMESCO Finland
Arthroplasty of first tarsometatarsal joint
5.5
10.8
31
58
WZA90
NOMESCO Finland
Other doctors statement
1.8
10.8
213
1319
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
3.8
10.7
44
119
UJF30
NOMESCO Finland
Ileoscopy through colon
2.3
10.6
99
454
G54.0
ICD-10 Finland
Brachial plexus disorders
14.4
10.5
17
12
M76.9
ICD-10 Finland
Enthesopathy of lower limb, unspecified
6.3
10.5
27
44
G54.8
ICD-10 Finland
Other nerve root and plexus disorders
111.2
10.4
11
*
ACC53
NOMESCO Finland
Release of ulnar nerve
+∞
10.4
10
*
2404
FHL
Nerve dissection (obturator 9364, Morton 9273, nerve tympanicus 4162)
+∞
10.4
10
*
J01FA10
ATC
azithromycin; systemic
1.6
10.3
514
4081
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.7
10.3
243
1583
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
2.2
10.3
105
505
M09AX01
ATC
hyaluronic acid; parenteral
2.9
10.3
63
228
M01AG02
ATC
tolfenamic acid; oral, rectal
1.9
10.2
152
852
NBG10
NOMESCO Finland
Acromioplastia
4.6
10.1
34
76
J20
ICD-10 Finland
Acute bronchitis
2.2
10.0
105
507
S46.0
ICD-10 Finland
Injury of muscle(s) and tendon(s) of the rotator cuff of shoulder
2.5
10.0
77
321
UKC02
NOMESCO Finland
Cystoscopy
2.0
10.0
141
773
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
3.3
9.9
49
154
N04BC05
ATC
pramipexole; oral
2.5
9.9
79
335
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
3.1
9.9
53
177
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.3
9.8
92
423
WX002
NOMESCO Finland
Sedation and analgesia
1.8
9.8
184
1115
N03AF01
ATC
carbamazepine; oral, rectal
3.0
9.7
55
188
G57.2
ICD-10 Finland
Lesion of femoral nerve
55.6
9.7
11
*
TQW40
NOMESCO Finland
Remowal of suture of skin
2.5
9.6
77
326
M75
ICD-10 Finland
Shoulder lesions
3.4
9.6
46
142
SPAT1212
SPAT
Extensive examination of musculoskeletal system
2.4
9.5
82
360
SPAT1215
SPAT
Assessment of need for medical rehabilitation
3.2
9.5
49
160
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
+∞
9.4
9
*
G54.4
ICD-10 Finland
Lumbosacral root disorders, not elsewhere classified
+∞
9.4
9
*
SHA01
NOMESCO Finland
Correction of physiology of bite - simple therapy visit
2.2
9.3
101
498
R52.1
ICD-10 Finland
Chronic intractable pain
10.8
9.3
17
16
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
2.1
9.3
109
555
M15.0
ICD-10 Finland
Primary generalized (osteo)arthrosis
3.9
9.3
37
98
R06AE07
ATC
cetirizine; oral
1.6
9.3
387
2919
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.1
9.2
111
573
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
2.1
9.2
108
551
H02AB04
ATC
methylprednisolone; systemic
1.9
9.2
144
821
SAA01
NOMESCO Finland
Simple examination of mouth
1.5
9.2
610
5118
M79.7
ICD-10 Finland
Fibromyalgia
3.4
9.1
43
131
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.6
9.1
297
2106
N05CD07
ATC
temazepam; oral
2.0
9.1
125
679
R03BA05
ATC
fluticasone; inhalant
1.8
9.1
167
1007
M01AH03
ATC
valdecoxib; oral
2.5
9.1
68
280
N05BA04
ATC
oxazepam; oral
1.7
9.0
238
1592
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
3.2
9.0
45
144
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
5.3
9.0
26
50
K07.60
ICD-10 Finland
Snapping jaw
3.0
8.9
51
177
A01
ICPC
Pain general/multiple sites
2.3
8.9
79
355
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.7
8.9
192
1213
M19.9
ICD-10 Finland
Arthrosis, unspecified
3.2
8.9
44
140
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
6.7
8.7
21
32
M01AB51
ATC
indometacin, combinations; oral, rectal
4.4
8.7
30
70
M75.9
ICD-10 Finland
Shoulder lesion, unspecified
3.0
8.7
49
168
SHA02
NOMESCO Finland
Correction of physiology of bite - basic therapy visit
2.5
8.7
68
285
WX110
NOMESCO Finland
Local anesthesy
1.5
8.7
597
5013
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
2.5
8.6
65
267
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.6
8.6
62
250
L16
ICPC
Ankle symptom/complaint
2.1
8.6
95
471
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
3.3
8.6
41
127
NH1AD
NOMESCO Finland
Ankle and foot CT
4.2
8.5
31
76
N05BA01
ATC
diazepam; systemic, rectal
1.9
8.5
125
697
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.5
8.5
488
3926
S43.4
ICD-10 Finland
Sprain and strain of shoulder joint
3.8
8.5
34
91
G51.0
ICD-10 Finland
Bell palsy
27.8
8.5
11
*
R01BA52
ATC
pseudoephedrine, combinations; oral
1.6
8.5
286
2038
XQ800
NOMESCO Finland
Prick test
2.3
8.5
74
331
AA1AD
NOMESCO Finland
CT of head and brain
1.7
8.5
206
1348
S83.2
ICD-10 Finland
Tear of meniscus, current
2.5
8.5
67
283
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.8
8.5
54
203
G58.9
ICD-10 Finland
Mononeuropathy, unspecified
90.8
8.4
9
*
35708
ICD-8 Finland
Other diseases of peripheral nerves except autonomic, Alterius nervi
+∞
8.3
8
*
NBE45
NOMESCO Finland
Plastic repair of ligament of shoulder not using prosthetic material, arthroscopic
8.6
8.3
17
20
S80.0
ICD-10 Finland
Contusion of knee
2.5
8.3
63
260
R01AD08
ATC
fluticasone; nasal
1.6
8.3
254
1764
NH1FA
NOMESCO Finland
Weight-bearing X-ray of ankle
9.6
8.3
16
17
P01AB01
ATC
metronidazole; oral, rectal
1.5
8.3
356
2682
9211
FHL
Exploration or removal of diskusprolapse
4.3
8.2
29
69
R05FB02
ATC
cough suppressants and expectorants
1.5
8.2
343
2570
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.2
8.2
83
396
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
4.2
8.1
29
70
NBA30
NOMESCO Finland
Exploration of joint of shoulder or upper arm, arthroscopic
3.7
8.1
34
95
L29
ICPC
Musculoskeletal sympt/complt other
2.3
8.1
73
330
ABD99
NOMESCO Finland
Other operation on spinal cord or nerve for pain or impaired function
33.6
8.1
10
*
A06AD11
ATC
lactulose; oral
1.9
8.1
121
678
TAC00
NOMESCO Finland
Peripheral nerve block
22.2
8.0
11
5
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
3.6
8.0
34
96
SHA03
NOMESCO Finland
Correction of physiology of bite - demanding therapy visit
3.7
8.0
33
91
D07AD01
ATC
clobetasol; topical
1.8
8.0
143
851
T93.2
ICD-10 Finland
Sequelae of other fractures of lower limb
7.3
8.0
18
25
R32
ICD-10 Finland
Unspecified urinary incontinence
3.5
8.0
36
107
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
3.3
8.0
38
118
L02
ICPC
Back symptom/complaint
2.2
8.0
84
408
UJF32
NOMESCO Finland
Coloscopy
1.6
7.9
226
1541
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.8
7.9
129
745
R30.1
ICD-10 Finland
Vesical tenesmus
4.6
7.9
26
58
R05
ICD-10 Finland
Cough
1.7
7.8
175
1115
M65.3
ICD-10 Finland
Trigger finger
3.2
7.8
39
125
JBC01
NOMESCO Finland
Laparoscopic gastro-oesophageal antireflux operation
4.2
7.8
28
68
R5599
NOMESCO Finland
Other rehabilitation service
3.9
7.8
30
78
J01FA09
ATC
clarithromycin; systemic
1.6
7.8
276
1982
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.4
7.8
64
279
R07.0
ICD-10 Finland
Pain in throat
2.5
7.8
57
233
NBG00
NOMESCO Finland
Plastic operation on acromioclavicular joint
5.1
7.8
23
46
M01AB01
ATC
indometacin; systemic, rectal
2.3
7.7
71
325
J01FA06
ATC
roxithromycin; oral
1.5
7.7
364
2787
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
2.5
7.7
60
253
B01AB05
ATC
enoxaparin; parenteral
1.5
7.7
275
1981
M22.4
ICD-10 Finland
Chondromalacia patellae
3.5
7.7
34
100
R07.3
ICD-10 Finland
Other chest pain
2.1
7.7
87
439
A03FA01
ATC
metoclopramide; systemic, rectal
1.6
7.6
199
1322
NHM10
NOMESCO Finland
Fasciotomy of ankle or foot
8.1
7.6
16
20
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.3
7.6
72
333
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.6
7.6
241
1685
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.7
7.5
157
980
M67.8
ICD-10 Finland
Other specified disorders of synovium and tendon
7.2
7.5
17
24
NB1BG
NOMESCO Finland
Shoulder and humerus MRI examination with high intensity magnet
4.9
7.5
23
48
J01CA04
ATC
amoxicillin; systemic
1.5
7.5
702
6196
J02AC02
ATC
itraconazole; systemic
1.7
7.4
165
1049
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.2
7.4
71
330
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
2.2
7.4
76
366
G50.1
ICD-10 Finland
Atypical facial pain
7.7
7.4
16
21
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
2.6
7.4
54
218
L01
ICPC
Neck symptom/complaint
1.8
7.4
123
716
R60.0
ICD-10 Finland
Localized oedema
1.9
7.4
103
563
E0000UV
ATC
NA
1.5
7.3
336
2550
M53.1
ICD-10 Finland
Cervicobrachial syndrome
2.0
7.3
93
492
3556A
ICD-9 Finland
Mononeuritis of lower limb, Lesion of plantar nerve
+∞
7.3
7
*
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
2.5
7.3
55
230
M47.9
ICD-10 Finland
Spondylosis, unspecified
3.6
7.2
31
89
NH3FA
NOMESCO Finland
Weight-bearing X-ray of foot
4.7
7.2
23
50
A02BC04
ATC
rabeprazole; oral
2.1
7.2
79
390
N05CF02
ATC
zolpidem; oral
1.7
7.2
157
991
R4120
NOMESCO Finland
Occupational therapy
2.4
7.2
57
243
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.5
7.2
373
2901
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
3.9
7.2
28
74
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.4
7.2
478
3913
N03AF02
ATC
oxcarbazepine; oral
3.5
7.2
32
95
6262A
ICD-9 Finland
Disorders of menstruation and other abnormal bleeding from female genital tract, Excessive or frequent menstruation[HYPERMENORRHOEA]
3.5
7.2
32
95
L84
ICD-10 Finland
Corns and callosities
3.2
7.2
36
117
R05
ICPC
Cough
1.6
7.1
196
1320
9473
FHL
Local soft tissue removal or exploration (eg Bursa)
6.6
7.1
17
26
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.0
7.1
93
495
M65.4
ICD-10 Finland
Radial styloid tenosynovitis [de Quervain]
4.1
7.1
26
65
NH1BG
NOMESCO Finland
Ankle and foot MRI examination with high intensity magnet
4.1
7.1
26
65
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.4
7.1
56
238
NK4EA
NOMESCO Finland
Joint X-ray examintion with load or wrench not elsewhere classified
6.1
7.1
18
30
SPAT1229
SPAT
Assessment of need for aid
2.1
7.1
74
360
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.7
7.0
143
886
Y88.3
ICD-10 Finland
Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.2
7.0
35
113
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.9
7.0
100
550
XG410
NOMESCO Finland
Flow-volume spirometry
2.8
7.0
43
160
L86
ICPC
Back syndrome with radiating pain
2.5
7.0
53
222
NHK10
NOMESCO Finland
Incision or excision of metatarsal or tarsal bone
6.4
7.0
17
27
TAB20
NOMESCO Finland
Epidural puncture
6.4
7.0
17
27
A03CA02
ATC
clidinium and psycholeptics; oral
2.3
6.9
63
287
L90
ICPC
Osteoarthrosis of knee
2.3
6.9
60
266
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.3
6.9
61
276
C10AA07
ATC
rosuvastatin; oral
1.6
6.9
207
1423
NHG26
NOMESCO Finland
Fusion between bones of ankle or ankle and foot
5.4
6.8
19
36
R01AD01
ATC
beclometasone; nasal
1.7
6.8
137
846
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
2.6
6.7
45
176
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
3.1
6.7
35
117
F45.8
ICD-10 Finland
Other somatoform disorders
2.3
6.7
60
273
NHL99
NOMESCO Finland
Other operation on muscle or tendon of ankle or foot
7.2
6.7
15
21
M23.8
ICD-10 Finland
Other internal derangements of knee
2.9
6.7
38
133
M76.7
ICD-10 Finland
Peroneal tendinitis
6.5
6.7
16
25
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.8
6.6
115
678
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.8
6.6
108
625
M76.8
ICD-10 Finland
Other enthesopathies of lower limb, excluding foot
4.1
6.6
24
60
M18.1
ICD-10 Finland
Other primary arthrosis of first carpometacarpal joint
4.1
6.6
24
60
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
6.6
134
827
F51.0
ICD-10 Finland
Nonorganic insomnia
1.8
6.6
109
630
M13.9
ICD-10 Finland
Arthritis, unspecified
2.1
6.6
68
329
9481
FHL
Detachment or severance of a muscle or tendon
12.3
6.6
11
9
G50.0
ICD-10 Finland
Trigeminal neuralgia
8.8
6.6
13
15
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
3.6
6.5
27
76
N05AH04
ATC
quetiapine; oral
1.7
6.5
130
798
NDG60
NOMESCO Finland
Arthroplasty of first CMC joint
5.1
6.5
19
38
NHK99
NOMESCO Finland
Other operation on bone of ankle or foot
3.7
6.5
26
71
WX212
NOMESCO Finland
Femoral plexus blockade
4.5
6.5
21
47
NHG82
NOMESCO Finland
Fusion of other tarsal joint
5.4
6.5
18
34
N64.4
ICD-10 Finland
Mastodynia
3.4
6.5
29
87
G43.9
ICD-10 Finland
Migraine, unspecified
2.5
6.5
47
193
M20.5
ICD-10 Finland
Other deformities of toe(s) (acquired)
5.7
6.5
17
30
J31.0
ICD-10 Finland
Chronic rhinitis
2.1
6.5
70
348
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
4.3
6.4
22
52
M54
ICD-10 Finland
Dorsalgia
1.8
6.4
101
576
S94.3
ICD-10 Finland
Injury of cutaneous sensory nerve at ankle and foot level
70.3
6.4
7
*
G56.8
ICD-10 Finland
Other mononeuropathies of upper limb
70.3
6.4
7
*
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
2.8
6.4
38
138
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.4
6.4
443
3624
S22.3
ICD-10 Finland
Fracture of rib
2.3
6.4
58
266
7352A
ICD-9 Finland
Acquired deformities of toe, Hallux rigidus
14.4
6.4
10
7
N07BC02
ATC
methadone; systemic
14.4
6.4
10
7
WX308
NOMESCO Finland
Sacral anesthesy
14.4
6.4
10
7
XF402
NOMESCO Finland
ECG with work load test
1.8
6.3
105
608
NG2AA
NOMESCO Finland
Patella X-ray examination
3.3
6.3
29
89
NB1CG
NOMESCO Finland
Shoulder and humerus extensive MRI examination with high intensity magnet
3.7
6.3
25
68
NHE15
NOMESCO Finland
Suture or reinsertion of ligament of ankle
11.1
6.3
11
10
NHA30
NOMESCO Finland
Exploration of joint of ankle or foot, arthroscopic
9.3
6.3
12
13
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
1.6
6.3
169
1130
N02AC04
ATC
dextropropoxyphene; oral
2.8
6.3
37
134
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
2.0
6.3
81
431
SPAT1211
SPAT
Application of soft bandage
2.0
6.3
77
402
AEA20
NOMESCO Finland
Removal of impulse generator of stimulation device in the nervous system
18.1
6.3
9
5
G58.8
ICD-10 Finland
Other specified mononeuropathies
+∞
6.3
6
*
ACA19
NOMESCO Finland
Exploration of peripheral nerve other or unspecified
+∞
6.3
6
*
ACB99
NOMESCO Finland
Other operation for lesion of peripheral nerve: other or unspecified
+∞
6.3
6
*
L14
ICPC
Leg/thigh symptom/complaint
2.1
6.2
68
338
M19.8
ICD-10 Finland
Other specified arthrosis
2.8
6.2
37
135
R60.9
ICD-10 Finland
Oedema, unspecified
2.5
6.2
45
185
WX702
NOMESCO Finland
Supraglottic ventilation device
2.5
6.2
47
197
I20.09
ICD-10 Finland
Unstable angina
2.4
6.2
48
205
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.4
6.2
433
3541
XQ802
NOMESCO Finland
Epicutan test
2.7
6.1
38
143
R06.5
ICD-10 Finland
Mouth breathing
2.0
6.1
70
356
Z47.8
ICD-10 Finland
Other specified orthopaedic follow-up care
7.7
6.1
13
17
L60.0
ICD-10 Finland
Ingrowing nail
2.7
6.1
40
154
H02.3
ICD-10 Finland
Blepharochalasis
2.1
6.1
63
307
L12
ICPC
Hand/finger symptom/complaint
1.7
6.1
115
694
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.0
6.1
73
375
T78.4
ICD-10 Finland
Allergy, unspecified
2.6
6.1
41
162
NH3BG
NOMESCO Finland
MRI of foot
8.7
6.1
12
14
NHG22
NOMESCO Finland
Fusion of subtalar joint
8.7
6.1
12
14
D07AC13
ATC
mometasone; topical
1.5
6.0
245
1799
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.4
6.0
373
2978
G04CA02
ATC
tamsulosin; oral
1.7
6.0
132
836
K59.1
ICD-10 Finland
Functional diarrhoea
2.4
6.0
49
213
M51.9
ICD-10 Finland
Intervertebral disc disorder, unspecified
6.1
6.0
15
25
Mortality – FinRegistry
↥Association
Association between endpoint G6_MONOLOWOTHUNS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MONOLOWOTHUNS | 1.054 [0.91, 1.22] | 0.49 |
| Birth year | 0.998 [0.99, 1.01] | 0.682 |
During the follow-up period (1.1.1998 — 31.12.2019), 254 out of 2459 females with G6_MONOLOWOTHUNS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MONOLOWOTHUNS | 1.209 [1.02, 1.44] | 0.03 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 237 out of 1432 males with G6_MONOLOWOTHUNS died.
Mortality risk
Mortality risk for people of age
years, who have G6_MONOLOWOTHUNS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.109% | 0.254% |
| 5 | 0.697% | 1.393% |
| 10 | 1.702% | 3.453% |
| 15 | 3.286% | 6.648% |
| 20 | 5.71% | 10.85% |
Relationships between endpoints
↥Index endpoint: G6_MONOLOWOTHUNS – Other and unspecified mononeuropathies of lower limb
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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