Chondromalacia

M13_CHONDROMALACIA

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M94.2
  • Cause of death: ICD-10 M94.2

2 out of 7 registries used, show all original rules.

1075

4. Check minimum number of events

None

1075

5. Include endpoints

None

1075

6. Filter based on genotype QC (FinnGen only)

1046

Control definitions (FinnGen only)

Control exclude
M13_OTHERBONE

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M94
Name in latin
Chondromalacia

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6397 3429 2943
Only index persons 6277 3389 2888
Unadjusted period prevalence (%)
Whole population 0.09 0.10 0.08
Only index persons 0.12 0.12 0.11
Median age at first event (years)
Whole population 43.93 44.37 43.45
Only index persons 43.84 44.31 43.28

-FinnGen-

Key figures

All Female Male
Number of individuals 1046 645 401
Unadjusted period prevalence (%) 0.21 0.23 0.18
Median age at first event (years) 46.27 45.18 48.02

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1075
Matched controls
10750
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
23.1
307.7
288
168
M94.2
ICD-10 Finland
Chondromalacia
+∞
307.7
1075
*
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
21.8
307.7
465
363
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
9.1
267.7
437
749
M22.4
ICD-10 Finland
Chondromalacia patellae
16.6
229.8
207
152
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
8.3
227.9
389
689
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
8.2
205.3
338
570
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
11.0
198.8
238
271
NGE10
NOMESCO Finland
Incision or suture of capsule of knee joint
35.1
159.8
102
32
M23.8
ICD-10 Finland
Other internal derangements of knee
9.8
128.1
160
189
NGF00
NOMESCO Finland
Excision of plica of synovy of knee
14.3
124.8
118
92
M17.1
ICD-10 Finland
Other primary gonarthrosis
4.2
108.8
418
1410
NG2AA
NOMESCO Finland
Patella X-ray examination
9.7
88.8
108
122
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
4.5
87.3
256
695
M01AX05
ATC
glucosamine; oral
3.7
75.5
320
1118
M25.5
ICD-10 Finland
Pain in joint
2.8
59.4
511
2622
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
3.5
57.8
246
848
NK4EA
NOMESCO Finland
Joint X-ray examintion with load or wrench not elsewhere classified
15.2
53.9
48
33
S83.2
ICD-10 Finland
Tear of meniscus, current
4.1
47.9
147
403
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
4.3
47.4
133
341
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
3.6
46.7
179
572
L15
ICPC
Knee symptom/complaint
2.6
45.5
353
1675
WX320
NOMESCO Finland
Spinalanesthesy
2.7
45.4
350
1654
M01AH05
ATC
etoricoxib; oral
2.7
42.9
818
5810
NGT99
NOMESCO Finland
Other operation on knee or lower leg
111.9
40.0
43
*
M23.3
ICD-10 Finland
Other meniscus derangements
8.2
38.6
52
66
M09AX01
ATC
hyaluronic acid; parenteral
5.0
37.2
84
180
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
3.0
36.2
181
674
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
4.1
34.8
100
260
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
4.3
33.6
91
226
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
2.8
33.0
189
756
M01AB05
ATC
diclofenac; systemic, rectal
2.4
32.1
815
6123
M01AE02
ATC
naproxen; oral, rectal
2.2
31.9
703
4981
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.1
29.1
559
3712
7177A
ICD-9 Finland
Internal derangement of knee, Chondromalacia of patella
7.2
27.3
41
59
N02AX02
ATC
tramadol; systemic, rectal
2.0
26.4
511
3364
S83.6
ICD-10 Finland
Sprain and strain of other and unspecified parts of knee
3.5
26.0
96
296
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
3.2
25.6
111
378
M24.2
ICD-10 Finland
Disorder of ligament
6.4
23.8
40
65
M01AC06
ATC
meloxicam; systemic, rectal
1.9
23.0
450
2933
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
2.9
22.5
114
423
1220
FHL
Arthroscopy
3.7
20.9
69
197
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.0
20.9
318
1893
N03AX16
ATC
[U] pregabalin
2.0
20.5
285
1642
M01AH01
ATC
celecoxib; oral
2.1
20.0
222
1177
B01AF01
ATC
rivaroxaban; oral
2.4
19.8
154
705
M79.6
ICD-10 Finland
Pain in limb
1.8
19.0
481
3341
NGF15
NOMESCO Finland
Total synovectomy of knee, arthroscopic
6.9
18.8
29
43
Z00.0
ICD-10 Finland
General medical examination
2.0
17.5
224
1246
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.0
17.5
216
1186
N02AJ06
ATC
codeine and paracetamol; systemic
1.7
17.2
490
3491
A02BC05
ATC
esomeprazole; systemic
1.7
17.2
463
3248
M19.0
ICD-10 Finland
Primary arthrosis of other joints
2.3
17.2
140
653
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.7
17.1
473
3343
H25.8
ICD-10 Finland
Other senile cataract
2.6
16.5
100
407
L08
ICPC
Shoulder symptom/complaint
1.9
16.4
255
1514
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
4.1
15.8
43
107
M17.3
ICD-10 Finland
Other post-traumatic gonarthrosis
4.0
15.6
45
117
M54.5
ICD-10 Finland
Low back pain
1.7
15.4
414
2880
N02BE01
ATC
paracetamol; systemic, rectal
2.3
15.3
971
8610
M01AB16
ATC
aceclofenac; oral
3.7
15.2
48
133
NBG10
NOMESCO Finland
Acromioplastia
4.2
14.5
39
96
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.8
14.4
302
1952
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.1
14.4
157
820
ZXA05
NOMESCO Finland
Left side
1.8
14.4
261
1617
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
14.0
391
2730
WX111
NOMESCO Finland
Local infiltration anesthesia
3.3
14.0
53
166
N02AA05
ATC
oxycodone; systemic
2.0
13.9
173
949
NGE15
NOMESCO Finland
Incision fo capsule of knee joint, arthroscopic
24.1
13.8
19
8
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.7
13.8
306
2007
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
13.8
309
2033
NG1BA
NOMESCO Finland
Knee extensive X-ray examination
4.1
13.7
38
96
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.5
13.4
91
391
S83.4
ICD-10 Finland
Sprain and strain involving (fibular)(tibial) collateral ligament of knee
3.2
13.3
53
171
X58
ICD-10 Finland
Exposure to other specified factors
2.0
13.1
170
944
Z75.1
ICD-10 Finland
Person awaiting admission to adequate facility elsewhere
4.2
13.0
34
82
NF1AA
NOMESCO Finland
Hip X-ray examination
2.4
13.0
92
402
ZXA00
NOMESCO Finland
Right side
1.7
12.9
273
1763
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
2.4
12.8
93
411
M02AA07
ATC
piroxicam; topical
1.6
12.8
379
2674
M03BX02
ATC
tizanidine; oral
1.6
12.8
706
5794
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.6
12.3
612
4873
B01AX06
ATC
[U] rivaroxaban
4.0
12.3
34
86
M23
ICD-10 Finland
Internal derangement of knee
3.6
12.2
40
114
XG410
NOMESCO Finland
Flow-volume spirometry
3.0
12.0
53
182
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.9
12.0
180
1048
L90
ICPC
Osteoarthrosis of knee
2.4
11.9
80
342
M70.6
ICD-10 Finland
Trochanteric bursitis
1.9
11.8
151
833
M01AX17
ATC
nimesulide; oral
1.7
11.7
255
1655
M02AA10
ATC
ketoprofen; topical
1.9
11.6
173
1003
M77.1
ICD-10 Finland
Lateral epicondylitis
2.1
11.6
109
537
PH2DE
NOMESCO Finland
Ultrasound examination of bloodflow in veins of lower extremity with Doppler method
3.3
11.6
43
133
NG1AA, ,
SPAT
2.2
11.6
98
463
1223
FHL
Arthroscopy and articular cartilage surgery
5.1
11.5
24
48
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
2.5
11.5
75
316
M25.2
ICD-10 Finland
Flail joint
4.8
11.2
25
53
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
4.6
11.2
26
57
H02AB06
ATC
prednisolone; systemic
1.6
11.2
494
3798
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.0
11.1
123
644
M75.2
ICD-10 Finland
Bicipital tendinitis
3.5
11.1
37
107
J01DB01
ATC
cefalexin; oral
1.8
11.0
885
7813
M54.4
ICD-10 Finland
Lumbago with sciatica
1.7
10.9
208
1298
NHE20
NOMESCO Finland
Plastic repair of capsule or ligament of ankle joint with transplant
15.7
10.8
17
11
M71.2
ICD-10 Finland
Synovial cyst of popliteal space [Baker]
3.0
10.8
47
160
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
2.7
10.8
60
234
NG1BG, ,
SPAT
2.7
10.8
56
211
H02BX01
ATC
methylprednisolone, combinations; systemic
2.8
10.7
54
200
R05FA02
ATC
opium derivatives and expectorants; systemic
1.6
10.7
410
3047
M01AB08
ATC
etodolac; oral
2.2
10.7
89
418
M01AC01
ATC
piroxicam; systemic, rectal
1.9
10.5
141
789
S93.2
ICD-10 Finland
Rupture of ligaments at ankle and foot level
4.9
10.5
23
48
J01AA02
ATC
doxycycline; systemic
1.7
10.5
835
7285
Z03.8
ICD-10 Finland
Observation for other suspected diseases and conditions
2.8
10.4
53
197
M93.2
ICD-10 Finland
Osteochondritis dissecans
+∞
10.4
10
*
ZXD20
NOMESCO Finland
Day surgery
1.9
10.3
146
831
NB1BG
NOMESCO Finland
Shoulder and humerus MRI examination with high intensity magnet
3.6
10.2
34
98
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.0
10.2
114
600
M01AH02
ATC
rofecoxib; oral
1.9
10.1
134
747
NJ3NA
NOMESCO Finland
Measurement of difference in extremity lengty with X-ray
4.5
10.1
24
54
SFA20
NOMESCO Finland
Two-surface restoration
1.5
10.0
643
5314
M01AE01
ATC
ibuprofen; systemic, rectal
2.1
9.9
991
9125
SPAT1153
SPAT
Removal of sutures
1.6
9.9
319
2270
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
2.8
9.8
48
175
M01AB55
ATC
diclofenac, combinations; oral
2.3
9.8
74
334
SAA02
NOMESCO Finland
Basic examination of mouth
1.5
9.7
713
6040
1222
FHL
Arthroscopy and synovial surgery
7.5
9.7
22
30
A02BC02
ATC
pantoprazole; systemic
1.5
9.7
704
5952
WX002
NOMESCO Finland
Sedation and analgesia
1.7
9.6
195
1235
WX110
NOMESCO Finland
Infiltration anesthesia
1.5
9.5
757
6513
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
9.4
555
4479
T93.3
ICD-10 Finland
Sequelae of dislocation, sprain and strain of lower limb
7.4
9.2
21
29
M01AE11
ATC
tiaprofenic acid; oral, rectal
2.7
9.2
48
181
SFA10
NOMESCO Finland
One-surface restoration
1.5
9.2
586
4796
W19
ICD-10 Finland
Unspecified fall
2.0
9.2
97
500
NBG00
NOMESCO Finland
Plastic operation on acromioclavicular joint
3.7
9.2
29
81
WZA90
NOMESCO Finland
Other medical or dental certificate
1.6
9.1
248
1691
00000, ,
ICD-8 Finland
5.1
9.1
19
38
K03.82
ICD-10 Finland
Split tooth for reasons other than trauma
1.6
9.1
270
1879
OAB93, ,
SPAT
2.2
9.0
75
353
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
3.0
9.0
38
128
M89.0
ICD-10 Finland
Algoneurodystrophy
24.2
8.9
12
5
SAA01
NOMESCO Finland
Simple examination of mouth
1.5
8.9
775
6741
S46.0
ICD-10 Finland
Injury of muscle(s) and tendon(s) of the rotator cuff of shoulder
2.0
8.9
95
492
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.0
8.7
98
517
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
3.4
8.7
31
94
S80.0
ICD-10 Finland
Contusion of knee
2.1
8.7
85
426
NE1BA
NOMESCO Finland
Pelvis extensive X-ray examination
4.4
8.6
21
48
J01FA10
ATC
azithromycin; systemic
1.5
8.5
617
5144
M13.9
ICD-10 Finland
Arthritis, unspecified
2.1
8.5
83
415
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
8.5
265
1862
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
3.4
8.2
29
87
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.5
8.2
467
3710
R06AE07
ATC
cetirizine; oral
1.5
8.2
457
3617
RF210, ,
NOMESCO Finland
2.9
8.1
37
130
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
1.9
8.0
105
583
R51.80
ICD-10 Finland
Headache
1.7
8.0
163
1031
X59
ICD-10 Finland
Exposure to unspecified factor
1.6
7.9
189
1244
J01FF01
ATC
clindamycin; systemic
1.5
7.9
278
2003
S18
ICPC
Laceration/cut
1.4
7.9
449
3560
N03AX12
ATC
[U] gabapentin; oral
1.7
7.8
173
1117
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.4
7.8
529
4326
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.6
7.8
186
1224
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.6
7.8
189
1249
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.4
7.7
500
4054
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
3.3
7.7
28
86
R03BA05
ATC
fluticasone; inhalant
1.6
7.7
188
1245
NBL05
NOMESCO Finland
Arthroscopic suture or reinsertation of rotator cuff of shoulder
3.8
7.7
23
62
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
2.0
7.5
80
413
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.0
7.5
83
435
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
2.6
7.5
42
165
WZA00
NOMESCO Finland
Concise certificate
2.0
7.5
76
386
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.3
7.5
58
265
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.8
7.4
111
642
G56.0
ICD-10 Finland
Carpal tunnel syndrome
1.7
7.4
154
978
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.2
7.4
63
299
M22.3
ICD-10 Finland
Other derangements of patella
13.5
7.4
12
9
R52.9
ICD-10 Finland
Pain, unspecified
1.9
7.4
100
561
SPAT1211
SPAT
Application of soft bandage
2.0
7.4
84
445
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
7.3
511
4186
M22.2
ICD-10 Finland
Patellofemoral disorders
9.4
7.3
14
15
B01AB05
ATC
enoxaparin; parenteral
1.5
7.3
299
2218
M16.1
ICD-10 Finland
Other primary coxarthrosis
1.8
7.2
105
604
M79.1
ICD-10 Finland
Myalgia
1.7
7.2
154
987
N05CF01
ATC
zopiclone; oral
1.5
7.1
310
2328
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.8
7.0
111
653
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
7.0
429
3424
G47.3
ICD-10 Finland
Sleep apnoea
1.5
7.0
245
1757
R4110, ,
SPAT
1.9
6.9
90
499
Z25.8
ICD-10 Finland
Need for immunization against other specified single viral diseases
1.7
6.9
120
726
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
2.8
6.8
33
120
M01AG02
ATC
tolfenamic acid; oral, rectal
1.6
6.8
171
1137
NGT60
NOMESCO Finland
Forcible manipulation of knee joint
4.1
6.8
18
44
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
1.7
6.8
115
690
M01AE03
ATC
ketoprofen; systemic, rectal
1.4
6.8
362
2816
M67.2
ICD-10 Finland
Synovial hypertrophy, not elsewhere classified
16.8
6.7
10
6
S20.2
ICD-10 Finland
Contusion of thorax
2.2
6.7
53
244
R01AD09
ATC
mometasone; nasal
1.4
6.7
484
3968
NBA30
NOMESCO Finland
Exploration of joint of shoulder or upper arm, arthroscopic
2.6
6.7
37
145
SFA30
NOMESCO Finland
Three-surface restoration
1.4
6.6
451
3657
M53.1
ICD-10 Finland
Cervicobrachial syndrome
1.7
6.6
125
775
9271
FHL
Hallux surgery
3.9
6.6
19
50
J02AC01
ATC
fluconazole; systemic
1.4
6.5
411
3286
Z01.2
ICD-10 Finland
Dental examination
1.4
6.5
459
3742
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
6.5
226
1617
R03AC02
ATC
salbutamol; inhalant
1.4
6.5
569
4810
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.5
6.5
232
1671
7170A
ICD-9 Finland
Internal derangement of knee, Old bucket handle tear of medial meniscus
3.4
6.4
22
65
M03BC01
ATC
orphenadrine (citrate); systemic
1.5
6.4
250
1829
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
2.3
6.4
45
197
L03
ICPC
Low back symptom/complaint
1.5
6.4
270
2006
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
2.1
6.4
56
269
H60.9
ICD-10 Finland
Otitis externa, unspecified
1.9
6.4
77
416
9243
FHL
Plastic of the patella and its tendons
3.8
6.4
19
51
UJF30
NOMESCO Finland
Ileoscopy through colon
1.8
6.4
102
603
WX290
NOMESCO Finland
Other blockage of nerve
1.4
6.4
495
4098
WX212
NOMESCO Finland
Femoral plexus blockade
3.2
6.3
24
76
SPAT1215
SPAT
Assessment of need for medical rehabilitation
2.4
6.3
43
186
NGB10
NOMESCO Finland
Primary partial prosthetic replacement of knee joint, demi prosthesis
5.6
6.3
17
31
Z04.3
ICD-10 Finland
Examination and observation following other accident
3.0
6.3
26
87
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
1.8
6.2
90
516
A02BC03
ATC
lansoprazole; oral
1.4
6.2
283
2134
N06AX21
ATC
duloxetine; oral
1.7
6.2
128
812
H02AB07
ATC
prednisone; oral
1.6
6.1
130
829
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.7
6.1
111
679
R05
ICD-10 Finland
Cough
1.5
6.1
207
1471
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.6
6.1
138
896
D07AC01
ATC
betamethasone; topical
1.4
6.1
346
2714
Y79.2
ICD-10 Finland
Orthopaedic devices associated with adverse incidents, prosthetic and other implants, materials and accessory devices
10.1
6.0
11
11
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
2.1
6.0
53
256

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
449
2471
2.40
41.27
4.3
3.5
—
—
—
0
0
257
1096
2.77
40.31
4.5
4.3
31.25
31.91
%
0.38
158
764
195
831
2.64
29.90
3.5
4.0
—
—
—
0
0
139
558
2.71
23.73
3.7
2.2
—
—
—
0
0
29
34
8.74
22.85
3.7
2.9
—
—
—
0
0
99
384
2.74
17.95
2.9
3.0
—
—
—
0
0
409
2752
1.78
17.69
2.0
2.2
—
—
—
0
0
331
2109
1.82
17.06
1.9
2.2
—
—
—
0
0
275
1669
1.87
16.49
1.3
1.3
28.10
32.75
iu/ml
0.39
103
560
65
212
3.20
16.04
3.0
2.1
—
—
—
0
0
803
6694
1.79
15.02
5.1
4.0
10.13
11.14
mm/h
1.61
742
6239
257
1603
1.79
13.80
1.3
1.3
8.89
13.41
u/ml
0.54
89
666
541
4192
1.58
12.21
2.5
2.4
—
—
—
0
0
59
214
2.86
12.14
1.9
1.6
7240.02
13461.04
e6/l
1.05
48
160
77
325
2.47
11.76
3.0
3.8
25.08
24.90
mmol/l
0.27
72
307
84
378
2.33
11.14
2.8
3.5
—
—
—
0
0
50
182
2.83
10.25
4.4
3.4
25.23
23.43
mg/l
0.14
34
111
51
193
2.72
9.73
3.4
4.0
—
—
—
0
0
513
4087
1.49
9.22
6.4
6.0
0.70
0.69
%
0.18
476
3825
526
4233
1.48
8.86
6.2
5.9
2.82
2.85
%
0.12
490
3976
540
4370
1.47
8.83
6.4
6.0
28.23
28.39
%
0.14
503
4122
100
529
1.98
8.79
2.6
3.5
5.24
5.12
kpa
1.09
91
512
737
6356
1.51
8.67
3.3
3.1
50.39
48.14
u/l
0.22
680
5991
98
521
1.97
8.50
2.6
3.5
7.44
7.41
ph
—
5
75
199
1308
1.64
8.44
1.3
1.3
398.89
532.84
titre
0.90
36
268
525
4252
1.46
8.39
6.7
6.2
8.44
8.49
%
0.15
490
4000
413
3194
1.48
8.38
3.4
3.2
50.93
39.60
ng/l
0.24
264
2079
43
162
2.72
8.30
1.7
1.5
—
—
—
0
0
475
3782
1.46
8.26
8.8
11.3
1.15
1.20
inr
0.50
94
1157
527
4309
1.44
7.80
6.1
5.8
56.99
56.82
%
0.13
494
4058
541
6368
0.70
7.72
3.2
3.5
—
—
—
0
0
27
84
3.27
7.28
1.2
1.3
11076.44
118352.74
e6/l
0.72
18
58
361
2802
1.43
6.87
2.3
2.4
54.49
58.74
u/l
1.02
332
2603
112
668
1.76
6.77
2.6
2.4
42.03
24.70
au/ml
0.85
11
56
539
4506
1.39
6.62
5.7
5.8
0.59
0.57
e9/l
1.46
472
3943
539
4510
1.39
6.56
5.8
5.8
0.04
0.04
e9/l
0.77
470
3951
551
4632
1.39
6.50
5.8
5.9
1.93
2.00
e9/l
0.46
493
4139
159
2309
0.63
6.48
3.4
3.6
0.00
0.01
estimate
0.88
57
807
974
9118
1.73
6.40
13.3
12.7
19.24
22.37
mg/l
2.20
794
7120
308
2359
1.43
6.19
2.2
2.6
16138.09
5214.93
umol/l
1.62
260
2107
169
1147
1.56
6.17
2.5
2.3
148.93
110.60
ug/g
0.78
141
924
551
4671
1.37
5.98
6.0
6.1
0.19
0.19
e9/l
0.22
495
4146
106
658
1.68
5.56
3.6
2.7
3.83
6.13
e9/l
1.51
68
551
589
5082
1.35
5.52
3.9
4.5
6.55
6.65
mmol/l
0.55
560
4753
183
2508
0.67
5.51
1.5
1.7
1.48
1.40
mmol/l
0.75
169
2123
28
107
2.66
5.34
1.5
1.4
49.90
57.43
%
0.41
21
69
71
398
1.84
5.31
1.7
1.7
—
—
—
0
0
27
104
2.64
5.08
1.2
1.2
—
—
—
0
0
989
9400
1.65
4.79
13.5
14.0
139.85
139.73
mmol/l
0.95
967
9166
38
755
0.49
4.76
3.1
3.6
—
—
—
0
0
991
9429
1.65
4.72
13.7
14.2
3.95
3.96
mmol/l
0.57
965
9181
24
91
2.67
4.67
2.4
2.7
—
—
—
0
0
13
27
4.86
4.50
1.7
8.3
—
—
—
0
0
529
4578
1.31
4.47
5.4
6.4
10.83
11.16
umol/l
0.33
497
4375
276
2180
1.36
4.42
2.5
2.9
829.67
962.66
ng/l
0.17
213
1838
70
415
1.73
4.38
2.6
2.2
—
—
—
0
0
758
6905
1.33
4.34
7.6
7.5
76.57
77.06
u/l
0.12
715
6534
592
5221
1.30
4.26
7.7
9.2
4.28
4.00
e9/l
0.50
523
4613
260
2045
1.36
4.26
1.6
1.7
0.90
1.06
mg/l
0.32
191
1564
54
303
1.82
4.08
2.2
2.6
—
—
—
0
0
492
4256
1.29
4.03
6.7
6.4
—
—
—
0
0
99
658
1.56
3.98
2.4
2.1
13.11
12.92
nmol/l
0.09
84
593
1018
9815
1.70
3.79
10.9
10.1
26.93
26.97
u/l
0.02
980
9513
191
2456
0.73
3.79
3.9
4.0
7.40
7.40
ph
0.24
30
473
394
3349
1.28
3.60
1.9
1.9
99.27
95.85
pmol/l
0.71
204
1752
434
3734
1.27
3.59
4.4
6.0
1.23
1.21
mmol/l
3.10
381
3427
426
3658
1.27
3.58
2.2
2.0
—
—
—
0
0
8
14
5.75
3.34
2.5
2.1
—
—
—
0
0
22
96
2.32
3.28
2.2
3.6
—
—
—
0
0
16
61
2.65
3.14
1.5
1.3
156.09
166.15
pmol/l
0.13
16
61
14
50
2.82
3.09
1.4
1.5
—
—
—
0
0
470
4137
1.24
3.05
6.3
6.8
1.23
1.21
mmol/l
3.07
426
3524
29
148
1.99
2.97
1.6
1.4
—
—
—
0
0
418
3643
1.24
2.95
2.4
2.3
76.98
76.07
nmol/l
0.28
362
3327
110
1488
0.71
2.94
2.6
3.0
2.43
2.44
mmol/l
0.16
86
1327
304
2556
1.26
2.94
2.0
2.1
196.15
239.31
u/l
0.21
286
2407
20
89
2.27
2.88
1.8
1.2
—
—
—
0
0
162
1265
1.33
2.74
1.3
1.2
—
—
—
0
0
167
1310
1.33
2.74
2.5
2.8
2.93
2.61
e6/l
0.20
112
704
58
374
1.58
2.72
1.1
1.1
—
—
—
0
0
995
9633
1.44
2.57
13.1
11.8
—
—
—
0
0
659
6082
1.22
2.50
4.3
4.0
—
—
—
0
0
1048
10270
1.81
2.48
19.7
18.7
6.85
6.62
e9/l
0.49
1028
10007
31
174
1.80
2.44
2.1
2.0
5.62
5.33
mmol/24h
0.17
25
151
1048
10274
1.80
2.41
19.9
18.8
137.69
136.54
g/l
2.02
1035
10138
14
58
2.43
2.37
1.0
1.6
5.24
6.15
ug/l
0.49
14
47
1047
10264
1.77
2.37
19.7
18.7
257.05
254.26
e9/l
0.76
1026
10022
1046
10254
1.74
2.33
19.5
18.8
39.03
40.48
%
5.29
1002
9671
28
155
1.83
2.31
1.4
1.2
—
—
—
0
0
1047
10268
1.76
2.31
19.6
18.6
90.98
90.89
fl
0.29
1034
10131
882
8419
1.27
2.30
5.3
4.7
1.74
2.01
mu/l
1.15
798
7787
1047
10269
1.75
2.29
19.6
18.6
30.41
30.31
pg
1.25
1034
10131
1047
10270
1.75
2.28
19.7
18.7
4.55
4.53
e12/l
0.49
1028
10010
8
23
3.50
2.27
1.1
2.0
—
—
—
0
0
11
41
2.70
2.21
4.1
2.2
—
—
—
0
0
9
30
3.02
2.15
2.1
2.5
—
—
—
0
0
30
175
1.73
2.11
1.1
1.1
—
—
—
0
0
30
175
1.73
2.11
1.1
1.1
—
—
—
0
0
63
440
1.46
2.11
2.4
2.7
0.26
0.15
e6/l
0.34
63
423
139
1105
1.30
2.09
1.4
1.4
—
—
—
0
0
7
20
3.52
2.05
1.0
1.3
0.07
2.16
mmol/l
—
7
20
220
1853
1.24
2.05
1.5
1.4
2.30
2.38
g/l
0.32
147
1173
19
97
1.98
2.01
2.2
1.4
—
—
—
0
0
43
640
0.66
1.97
4.6
9.0
—
—
—
0
0
16
307
0.51
1.94
2.8
4.6
—
—
—
0
0
75
552
1.39
1.90
2.2
2.2
—
—
—
0
0
149
1211
1.27
1.90
2.0
2.0
—
—
—
0
0
50
343
1.48
1.85
1.6
1.6
—
—
—
0
0
18
93
1.95
1.85
1.0
1.1
—
—
—
0
0
13
59
2.22
1.84
1.4
1.4
—
—
—
0
0
926
8942
1.26
1.84
5.0
4.3
5.94
5.89
mmol/l
0.51
833
8267
94
722
1.33
1.83
1.3
1.2
—
—
—
0
0
5
12
4.18
1.82
1.0
1.0
—
—
—
0
0
165
1365
1.25
1.81
1.8
1.7
904.41
1190.66
nmol/l
4.82
117
1054
880
8456
1.22
1.80
6.6
5.3
39.69
39.36
mmol/mol
0.53
800
7904
41
272
1.53
1.79
1.4
1.5
301.99
303.39
ug/g
0.02
32
162
65
879
0.72
1.78
5.4
8.4
0.42
1.10
mmol/l
0.87
53
711
0
46
0.00
1.71
0.0
28.3
—
7.21
—
0
41
241
2087
1.20
1.69
1.3
1.2
2.23
1.62
u/ml
0.25
67
594
5
14
3.58
1.61
1.2
1.0
—
—
—
0
0
5
14
3.58
1.61
1.2
1.0
—
—
—
0
0
5
14
3.58
1.61
1.2
1.0
—
—
—
0
0
17
91
1.88
1.61
2.4
2.6
4.08
4.00
mmol/l
0.59
17
91
17
91
1.88
1.61
2.4
2.6
104.53
105.56
mmol/l
0.43
17
91
920
8911
1.22
1.56
4.6
3.9
1.32
1.31
mmol/l
0.06
842
8277
10
44
2.28
1.55
1.5
1.2
—
—
—
0
0
124
1014
1.25
1.53
1.3
1.3
—
—
—
0
0
147
1747
0.82
1.50
2.4
2.4
5.01
6.04
e6/l
0.53
131
1587
22
131
1.69
1.50
1.1
1.0
0.83
3.30
u/ml
—
7
52
31
202
1.55
1.50
1.8
1.6
—
—
—
0
0
18
101
1.80
1.49
1.1
1.3
—
—
nmol/l
—
0
0
275
2441
1.17
1.45
3.2
3.0
—
—
—
0
0
11
52
2.13
1.44
1.7
3.1
702.55
731.77
u/ml
0.06
11
52
42
297
1.43
1.39
2.0
3.8
0.43
0.25
g/l
0.60
17
130
137
1146
1.22
1.39
1.2
1.3
—
—
—
0
0
296
2655
1.16
1.35
5.6
4.5
2.12
2.21
ug/l
0.13
262
2402
28
183
1.54
1.35
1.3
1.1
0.51
2.10
u/ml
1.63
12
94
9
42
2.15
1.34
1.1
1.1
103.19
250.59
iu/ml
—
9
42
945
9209
1.22
1.31
5.0
4.3
1.47
1.48
mmol/l
0.12
865
8583
53
700
0.74
1.30
8.4
8.6
9.92
9.08
mmol/l
0.36
53
669
16
91
1.77
1.29
2.5
2.6
—
—
—
0
0
11
55
2.01
1.27
1.0
1.0
—
—
—
0
0
172
1981
0.84
1.27
3.3
3.2
—
—
—
0
0
23
147
1.58
1.23
1.0
1.0
1.52
2.05
u/ml
0.31
13
71
162
1395
1.19
1.23
2.4
2.6
0.74
1.08
e6/l
1.10
107
782
33
229
1.46
1.23
1.3
1.3
602.00
505.10
mg/l
0.27
33
214
11
56
1.97
1.22
1.0
1.0
—
—
—
0
0
21
132
1.60
1.21
2.7
3.3
1.31
1.40
%
0.04
16
119
9
169
0.53
1.19
3.0
2.8
—
—
—
0
0
25
165
1.53
1.18
1.2
1.4
—
—
—
0
0
19
297
0.63
1.17
10.5
9.6
—
—
—
0
0
76
611
1.26
1.13
1.2
1.2
—
—
—
0
0
337
3089
1.13
1.11
2.5
3.3
31.73
31.53
u/l
0.04
329
2955
111
934
1.21
1.09
1.2
1.4
—
—
—
0
0
12
66
1.83
1.09
1.1
1.6
7.73
6.71
mmol/l
—
6
45
8
41
1.96
1.09
2.6
2.0
4.23
3.26
ug/l
—
8
36
90
742
1.23
1.08
4.2
4.3
0.55
1.03
%
1.69
33
258
7
32
2.19
1.08
1.0
1.1
—
—
—
0
0
86
706
1.24
1.08
4.3
4.4
0.00
0.14
%
5.80
30
221
83
679
1.24
1.07
3.6
4.3
0.43
0.58
%
0.49
28
220
945
9242
1.19
1.05
4.9
4.3
4.79
4.77
mmol/l
0.40
868
8665
735
7068
1.13
1.05
4.3
4.0
14.92
14.62
pmol/l
2.65
659
6509
23
154
1.50
1.04
1.3
1.2
8.56
7.12
u/ml
—
9
60
9
46
1.96
1.03
2.2
3.0
33833.33
40532.72
ug/l
—
9
46
8
150
0.53
1.03
1.6
2.5
—
—
—
0
0
48
368
1.32
1.03
1.3
1.2
—
—
—
0
0
18
114
1.59
1.03
1.1
1.3
0.74
0.59
nmol/l
0.26
18
106
32
230
1.40
1.02
1.3
1.3
—
—
—
0
0
201
2247
0.87
1.02
2.9
2.9
—
—
—
0
0
70
566
1.25
1.01
2.7
3.6
4.61
4.55
pmol/l
0.21
61
499
324
3511
0.89
1.00
3.1
3.1
5.71
5.81
ph
0.25
26
316
9
48
1.88
1.00
1.0
1.3
221.22
486.26
u/l
—
9
43
7
35
2.01
1.00
1.4
1.3
—
—
—
0
0
7
35
2.01
1.00
1.3
1.5
—
—
—
0
0
86
713
1.22
1.00
2.5
2.6
11.22
10.48
g/l
0.34
79
664
24
164
1.47
0.99
1.1
1.0
4.07
5.58
u/ml
0.20
11
75
23
156
1.48
0.99
1.1
1.0
0.67
1.77
u/ml
—
7
75
0
29
0.00
0.98
0.0
2.1
—
—
—
0
0
9
50
1.81
0.96
1.2
1.3
—
—
—
0
0
13
77
1.70
0.95
1.5
1.1
—
—
—
0
0
0
32
0.00
0.95
0.0
4.6
—
—
—
0
0
26
183
1.43
0.94
1.2
1.5
—
—
—
0
0
23
158
1.47
0.94
1.2
1.1
—
—
—
0
0
62
763
0.80
0.93
1.4
1.6
—
—
—
0
0
14
86
1.64
0.91
1.2
1.7
—
—
—
0
0
38
289
1.33
0.89
1.4
2.1
10.91
10.21
g/l
0.28
32
272
9
154
0.58
0.89
1.0
1.4
—
—
—
0
0
373
3982
0.90
0.86
8.4
9.0
0.14
0.00
e9/l
0.49
305
3295
417
3922
1.10
0.84
2.7
2.7
112.79
119.24
ug/l
0.29
390
3664
382
3579
1.10
0.83
4.7
4.9
36.89
36.03
g/l
2.62
358
3363
77
646
1.21
0.82
2.6
2.7
67.25
67.03
g/l
0.11
68
601
11
65
1.70
0.82
2.5
2.2
0.28
0.21
e9/l
0.40
11
58
22
155
1.43
0.81
1.1
1.0
0.20
1.72
u/ml
—
7
61
8
47
1.71
0.80
2.0
1.7
—
—
—
0
0
74
621
1.21
0.79
3.3
4.1
61.42
85.01
ng/l
3.23
54
564
39
494
0.78
0.78
4.4
5.8
—
—
—
0
0
79
669
1.20
0.78
4.4
4.5
0.05
0.63
%
0.65
22
183
11
67
1.65
0.75
1.1
1.1
—
—
—
0
0
11
67
1.65
0.75
2.5
2.2
629.09
585.60
e6/l
0.09
11
58
10
60
1.67
0.72
3.0
2.1
—
—
—
0
0
94
1079
0.86
0.71
1.6
1.6
—
—
—
0
0
23
169
1.37
0.70
1.3
1.2
—
—
—
0
0
95
828
1.16
0.68
3.0
4.5
60.77
16.91
ug/l
0.52
80
669
462
4407
1.08
0.66
3.7
3.3
0.00
0.01
estimate
0.80
55
790
13
190
0.68
0.65
6.4
4.0
55.62
56.29
%
0.08
13
190
16
112
1.44
0.63
1.9
2.8
—
—
—
0
0
6
101
0.59
0.62
1.3
1.2
—
—
—
0
0
11
71
1.55
0.62
1.3
1.1
—
—
—
0
0
5
30
1.67
0.61
1.8
1.6
—
—
—
0
0
349
3685
0.92
0.61
2.8
2.7
—
—
—
0
0
67
574
1.18
0.61
1.8
1.7
1.06
1.42
g/l
2.01
57
538
8
51
1.57
0.60
1.1
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
1.19
—
0
14
206
2225
0.91
0.60
3.3
3.8
94.10
93.40
%
0.16
200
2169
31
245
1.27
0.60
1.3
1.3
10.40
10.86
u/l
0.07
26
203
0
22
0.00
0.59
0.0
1.4
—
51.60
—
0
15
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
204
1888
1.10
0.58
1.4
1.5
20.77
21.30
nmol/l
0.20
161
1620
36
292
1.24
0.57
2.4
2.0
1655.98
3300.35
u/l
—
8
109
13
184
0.70
0.57
5.4
3.6
4.00
4.19
e9/l
0.15
13
184
74
645
1.16
0.56
1.5
1.4
—
—
—
0
0
94
834
1.14
0.56
2.1
2.1
350.18
372.31
nmol/l
0.53
85
765
172
1582
1.10
0.56
3.4
2.8
0.67
0.72
ug/l
0.69
103
975
21
160
1.32
0.53
1.5
3.0
—
—
—
0
0
55
470
1.18
0.53
3.7
3.2
136.60
129.87
g/l
1.56
55
464
589
5705
1.07
0.53
4.3
3.9
64.00
751.47
e6/l
—
6
81
109
982
1.12
0.52
2.1
1.7
—
—
—
0
0
14
100
1.41
0.52
1.4
1.3
—
—
—
0
0
13
180
0.72
0.51
1.5
3.2
—
—
—
0
0
15
109
1.38
0.51
1.2
1.2
—
—
—
0
0
95
1058
0.89
0.50
1.3
1.3
—
—
—
0
0
187
1740
1.09
0.49
1.5
1.6
407.13
15505891.75
pmol/l
1.29
157
1464
7
107
0.65
0.49
2.6
2.5
—
—
—
0
0
12
166
0.72
0.48
1.3
1.4
—
—
—
0
0
23
182
1.27
0.46
3.0
3.7
—
—
—
0
0
40
471
0.84
0.46
1.1
1.0
—
—
—
0
0
110
1001
1.11
0.45
1.5
1.4
—
—
—
0
0
10
69
1.45
0.44
1.0
1.0
—
—
—
0
0
30
361
0.83
0.44
2.5
2.6
0.65
0.66
%
0.06
30
361
20
157
1.28
0.43
1.9
4.0
14.30
396.61
u/ml
1.56
20
148
60
680
0.88
0.43
1.1
1.2
149.00
148.64
iu/ml
0.00
22
273
12
162
0.74
0.42
1.3
1.3
—
—
—
0
0
14
184
0.76
0.42
1.4
2.3
133.75
131.81
g/l
—
8
137
0
15
0.00
0.41
0.0
1.2
—
2.03
—
0
15
12
161
0.74
0.41
1.3
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
41.60
—
0
5
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
0
17
0.00
0.40
0.0
2.9
—
4729.29
—
0
17
0
17
0.00
0.40
0.0
1.0
—
—
—
0
0
32
269
1.20
0.40
1.4
1.2
—
1232.73
—
0
11
23
281
0.81
0.39
6.7
1.7
—
—
—
0
0
38
325
1.18
0.39
1.4
2.1
20.55
21.37
s
0.40
31
286
30
251
1.20
0.39
1.2
1.1
—
—
—
0
0
256
2689
0.94
0.39
3.8
3.1
7.52
7.75
mmol/l
0.41
191
2309
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
12
89
1.35
0.38
1.9
2.9
0.97
1.41
g/24h
—
6
50
29
243
1.20
0.38
1.5
2.1
38.09
38.24
g/l
0.05
23
227
9
68
1.33
0.37
1.0
1.2
—
—
—
0
0
14
107
1.31
0.37
1.1
1.3
—
—
—
0
0
33
281
1.18
0.37
1.3
1.6
0.26
0.24
g/l
0.64
33
267
142
1328
1.08
0.35
1.5
1.6
—
—
—
0
0
15
117
1.29
0.35
1.0
1.3
—
25.30
—
0
6
215
2043
1.07
0.34
2.1
2.1
2.69
2.92
mg/l
1.22
184
1749
17
210
0.81
0.33
7.9
2.1
—
—
—
0
0
88
808
1.10
0.33
2.6
2.5
31.11
42.12
u/l
1.05
76
706
114
1060
1.08
0.33
1.6
1.6
—
—
—
0
0
10
132
0.76
0.32
13.8
1.7
—
—
—
0
0
11
83
1.33
0.32
1.7
2.2
—
—
—
0
0
12
92
1.31
0.32
1.2
1.1
—
—
—
0
0
7
97
0.72
0.31
2.0
1.3
—
—
—
0
0
10
131
0.76
0.31
3.3
1.6
—
—
—
0
0
10
131
0.76
0.31
2.0
1.9
—
—
—
0
0
7
99
0.71
0.30
2.3
2.3
—
—
—
0
0
26
303
0.85
0.29
6.2
1.7
—
—
—
0
0
19
157
1.21
0.29
1.2
1.2
—
—
—
0
0
26
302
0.86
0.29
6.2
1.7
—
—
—
0
0
946
9382
1.07
0.28
5.2
4.7
2.86
2.85
mmol/l
0.19
864
8750
10
76
1.32
0.28
1.2
1.2
—
—
—
0
0
75
691
1.09
0.28
2.7
3.2
—
—
—
0
0
150
1580
0.94
0.27
3.0
3.5
20.87
375.02
ng/l
6.37
93
1153
56
510
1.10
0.26
1.3
1.2
—
—
—
0
0
15
182
0.82
0.26
1.3
1.5
—
—
—
0
0
5
71
0.70
0.26
1.8
2.3
553.60
634.98
ml
—
5
48
5
72
0.69
0.26
1.6
1.3
70.40
77.00
umol/l
—
5
72
246
2370
1.05
0.26
2.8
2.6
—
—
—
0
0
73
675
1.09
0.26
1.4
1.4
—
—
—
0
0
9
72
1.25
0.25
1.3
1.6
1.70
1.19
promille
—
9
57
15
123
1.22
0.25
1.9
3.0
—
—
—
0
0
9
74
1.22
0.25
1.1
1.4
—
—
—
0
0
288
2974
0.96
0.25
3.5
3.5
45.06
81.22
e6/l
0.80
212
2094
9
76
1.19
0.24
1.4
1.5
0.81
1.01
g/l
—
9
76
171
1635
1.05
0.24
2.8
2.7
608.84
545.45
mosm/kgh2o
1.77
151
1428
72
669
1.08
0.23
1.2
1.5
—
—
—
0
0
86
805
1.07
0.23
2.5
2.3
0.22
0.22
g/l
0.10
81
760
37
332
1.12
0.23
1.6
1.5
244.19
301.45
mu/l
1.08
37
304
131
1376
0.95
0.22
2.6
3.6
0.82
0.82
mmol/l
0.07
120
1302
27
305
0.88
0.22
6.0
1.7
—
—
—
0
0
5
41
1.22
0.22
28.8
31.1
135.60
132.50
ug/l
—
5
34
105
1109
0.94
0.22
2.3
2.5
22.80
23.51
%
0.19
87
949
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
3.5
—
—
—
0
0
0
10
0.00
0.21
0.0
6.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
27
304
0.89
0.21
6.0
1.7
—
—
—
0
0
12
98
1.23
0.21
1.2
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
245
2527
0.96
0.21
1.4
1.4
—
—
—
0
0
223
2157
1.04
0.20
3.3
4.2
—
—
—
0
0
0
14
0.00
0.20
0.0
7.4
—
0.30
—
0
14
27
240
1.13
0.20
2.3
3.3
—
—
—
0
0
6
50
1.20
0.19
1.2
1.1
—
13.00
—
0
5
113
1079
1.05
0.18
5.2
6.2
1.01
1.03
mmol/l
0.30
100
1004
155
1609
0.96
0.18
1.6
1.8
—
—
—
0
0
35
319
1.10
0.18
1.6
2.0
0.49
2.27
ug/l
1.24
28
290
233
2264
1.04
0.18
5.6
6.7
—
—
—
0
0
11
92
1.20
0.16
2.5
2.1
1.59
1.24
e9/l
0.67
11
84
74
702
1.06
0.15
3.1
3.8
2.28
1.86
mmol/l
0.82
60
585
24
216
1.11
0.15
1.5
2.8
24.66
24.53
mmol/l
0.09
24
216
6
80
0.75
0.15
2.3
1.8
40.75
39.10
%
—
6
80
193
1876
1.04
0.15
3.7
3.5
1.02
1.02
kg/l
0.66
62
255
134
1295
1.04
0.14
2.2
2.5
14.37
13.66
umol/l
0.51
122
1209
21
233
0.90
0.14
7.2
1.5
—
—
—
0
0
38
408
0.93
0.14
5.2
10.4
24.54
24.41
mmol/l
0.07
38
403
8
96
0.83
0.13
2.0
2.4
32.63
33.19
pg
—
8
96
27
247
1.10
0.13
1.9
2.0
20.38
4.85
iu/l
—
8
93
22
199
1.11
0.13
1.2
1.5
4.12
12.45
e6/l
1.02
17
157
245
2502
0.97
0.13
3.3
3.2
1239.25
312.68
mg/l
0.86
129
1594
10
85
1.18
0.12
1.2
2.1
—
—
—
0
0
31
288
1.08
0.12
1.2
1.3
—
—
—
0
0
267
2623
1.02
0.11
4.1
3.8
3.66
8.44
mg/mmol
3.44
165
1649
65
678
0.96
0.10
1.8
2.3
6.88
7.02
ug/l
0.02
50
610
31
331
0.93
0.10
1.3
1.9
1.56
1.51
g/l
0.11
22
289
5
48
1.04
0.09
1.2
1.2
—
—
—
0
0
5
48
1.04
0.09
1.0
1.5
—
—
—
0
0
6
54
1.11
0.09
1.2
1.1
—
—
—
0
0
117
1199
0.97
0.08
2.2
2.4
2.44
2.37
g/l
0.86
107
1121
65
627
1.04
0.08
2.6
2.8
70.47
73.04
e9/l
0.29
54
485
5
61
0.82
0.08
1.0
1.3
5.38
6.35
u/l
—
5
49
5
60
0.83
0.08
1.2
1.6
—
—
—
0
0
7
65
1.08
0.08
1.3
1.4
1.58
1.55
g/l
—
7
65
78
757
1.03
0.07
1.3
1.4
—
—
—
0
0
9
84
1.07
0.07
2.1
7.5
6.47
7.32
mmol/l
—
9
70
9
87
1.03
0.07
1.0
1.1
—
—
—
0
0
9
103
0.87
0.06
1.1
1.2
—
—
—
0
0
432
4351
0.99
0.06
3.4
3.3
0.00
0.00
estimate
0.50
62
865
27
258
1.05
0.04
1.1
1.2
—
—
—
0
0
254
2518
1.01
0.04
3.0
3.0
37.52
80.61
e6/l
0.84
200
1952
15
160
0.94
0.04
1.5
1.1
—
—
—
0
0
16
151
1.06
0.03
1.4
1.1
—
—
—
0
0
18
172
1.05
0.02
1.3
1.3
310.43
253.69
u/ml
—
7
106
228
2289
1.00
0.01
2.9
2.9
0.16
0.39
e6/l
2.55
175
1748
41
417
0.98
0.01
6.5
11.2
—
—
—
0
0
288
2886
1.00
0.00
3.2
3.5
2.37
2.35
mmol/l
1.17
225
2591
435
4356
1.00
0.00
5.5
4.4
0.00
0.00
estimate
0.50
57
824
17
166
1.02
0.00
1.1
1.2
—
—
—
0
0
20
198
1.01
0.00
1.1
1.3
—
—
—
0
0
30
302
0.99
0.00
1.5
1.3
179.62
228.37
miu/ml
0.27
13
145
10
99
1.01
0.00
1.7
1.8
—
—
—
0
0
17
167
1.02
0.00
2.2
1.6
—
—
—
0
0
85
847
1.00
0.00
2.4
2.7
1.81
1.81
%
0.01
71
767
27
265
1.02
0.00
1.0
1.1
—
—
—
0
0
59
595
0.99
0.00
1.7
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
183.80
—
0
5
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
54
0.93
-0.00
1.2
1.4
140.00
168.94
mmol/24h
—
5
54
0
5
0.00
-0.00
0.0
1.4
—
168.20
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
36.63
—
0
8
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
5
59
0.85
-0.00
11.8
10.6
0.52
0.65
mmol/l
—
5
52
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
19.18
—
0
6
0
6
0.00
-0.00
0.0
4.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint M13_CHONDROMALACIA and mortality.

Females

Parameter HR [95% CI] p-value
M13_CHONDROMALACIA 0.686 [0.57, 0.83] < 0.001
Birth year 0.993 [0.98, 1.0] 0.102

During the follow-up period (1.1.1998 — 31.12.2019), 116 out of 3100 females with M13_CHONDROMALACIA died.

Males

Parameter HR [95% CI] p-value
M13_CHONDROMALACIA 0.576 [0.49, 0.68] < 0.001
Birth year 0.99 [0.98, 1.0] 0.087

During the follow-up period (1.1.1998 — 31.12.2019), 161 out of 2662 males with M13_CHONDROMALACIA died.

Mortality risk

Mortality risk for people of age

years, who have M13_CHONDROMALACIA.

N-year risk Females Males
1 0.059% 0.107%
5 0.404% 0.732%
10 0.936% 1.884%
15 1.833% 3.6%
20 3.238% 6.105%

Relationships between endpoints

Index endpoint: M13_CHONDROMALACIA – Chondromalacia

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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