macular holes: Perforations through the whole thickness of the retina including the macula as the result of inflammation, trauma, degeneration, etc. The concept includes retinal breaks, tears, dialyses, and holes.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2128 |
4. Check minimum number of eventsNone |
2128 |
5. Include endpointsNone |
2128 |
6. Filter based on genotype QC (FinnGen only) |
2082 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 5
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H35
Similar endpoints
↥List of similar endpoints to
Macular hole
based on the number of shared cases.
Similar with more cases:
- Degeneration of macula and posterior pole
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any operation in hilmo
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10837 | 6967 | 3864 |
| Only index persons | 10716 | 6888 | 3828 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.17 | 0.20 | 0.11 |
| Only index persons | 0.21 | 0.25 | 0.15 |
| Median age at first event (years) | |||
| Whole population | 70.78 | 70.21 | 71.81 |
| Only index persons | 70.75 | 70.16 | 71.82 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2082 | 1256 | 826 |
| Unadjusted period prevalence (%) | 0.42 | 0.45 | 0.38 |
| Median age at first event (years) | 70.39 | 69.04 | 72.45 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 2128
- Matched controls
- 21280
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
438.7
307.7
450
13
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
4321.4
307.7
643
*
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
115.1
307.7
189
18
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
572.3
307.7
486
11
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
14.3
307.7
736
759
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
1645.6
307.7
676
6
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
187.5
307.7
480
33
H35.37
ICD-10 Finland
Macular holes
4503599627370496.0
307.7
2122
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
12.1
307.7
792
995
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
6.8
307.7
1506
5606
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
220.4
307.7
505
30
Z96.1
ICD-10 Finland
Presence of intraocular lens
7.2
307.7
863
1838
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
1115.2
307.7
443
5
WX140
NOMESCO Finland
Parabulbar anesthesy
95.3
307.7
1039
211
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
95.5
289.7
151
17
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
4.9
276.9
1391
5921
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
21.5
274.8
210
108
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
9.1
264.3
354
457
CKC12
NOMESCO Finland
Photocoagulation of retina
62.6
263.0
146
25
H26.4
ICD-10 Finland
After-cataract
5.7
251.1
583
1331
CJB10
NOMESCO Finland
Laser discission of secondary cataract
5.7
219.4
487
1059
H25.1
ICD-10 Finland
Senile nuclear cataract
3.8
204.3
1149
4984
WX142
NOMESCO Finland
Sub-tenon anesthesy
50.1
196.8
114
24
CKD40
NOMESCO Finland
Endophotocoagulation of retina
664.7
187.9
183
*
H33.0
ICD-10 Finland
Retinal detachment with retinal break
951.3
181.0
175
*
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
341.9
157.1
157
5
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.5
133.7
608
2197
H33.3
ICD-10 Finland
Retinal breaks without detachment
249.7
116.1
118
5
H26.2
ICD-10 Finland
Complicated cataract
16.8
112.7
95
59
WX002
NOMESCO Finland
Sedation and analgesia
2.9
105.6
693
3044
XCK10
NOMESCO Finland
Photography of fundus of eye
3.9
104.7
346
999
S01ED51
ATC
timolol, combinations; ophthalmic
4.0
103.0
334
951
XCH00
NOMESCO Finland
Eye pressure measurement
5.5
102.6
212
421
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.9
88.3
505
2034
H35.36
ICD-10 Finland
Macular cyst
+∞
85.0
81
*
XCD20
NOMESCO Finland
Photoangiography of eye
33.3
81.0
52
16
CKD95
NOMESCO Finland
Extended combined vitectomy and lens procedure through pars plana
164.0
75.6
79
5
ZXA00
NOMESCO Finland
Right side
2.2
65.0
788
4428
ZXA05
NOMESCO Finland
Left side
2.3
63.8
734
4030
H35.7
ICD-10 Finland
Separation of retinal layers
+∞
61.8
59
*
ZXA10
NOMESCO Finland
Bilateral
2.4
58.6
540
2686
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
583.5
57.9
57
*
H43.1
ICD-10 Finland
Vitreous haemorrhage
7.9
54.1
75
98
CKD20
NOMESCO Finland
Removal of vitreous body substitute
509.7
50.6
50
*
CKD15
NOMESCO Finland
Injection of vitreous substitute
+∞
48.1
46
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.9
44.9
1103
7700
CK2M4
NOMESCO Finland
Macular light layer imaging (OCT)
15.5
40.0
35
23
ZXE00
NOMESCO Finland
One hour or less
1.8
38.0
883
5962
S01BC05
ATC
ketorolac; ophthalmic
3.6
36.3
123
355
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
2.7
32.0
183
717
CKC20
NOMESCO Finland
Cryopexy of undetached retina
321.7
31.9
32
*
H43.8
ICD-10 Finland
Other disorders of vitreous body
2.3
31.8
269
1264
H53.1
ICD-10 Finland
Subjective visual disturbances
2.7
31.0
178
698
CKC10
NOMESCO Finland
Local photocoagulation of retina
38.7
30.3
38
10
H3601, E113,
ICD-10 Finland
+∞
30.3
29
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
30.2
850
5953
H25.0
ICD-10 Finland
Senile incipient cataract
2.5
29.3
205
884
H34.8
ICD-10 Finland
Other retinal vascular occlusions
40.7
29.0
36
9
A98
ICPC
Health maint/preventive medicine
3.8
28.3
2064
19015
H53.9
ICD-10 Finland
Visual disturbance, unspecified
3.4
28.2
105
322
H35.8
ICD-10 Finland
Other specified retinal disorders
274.4
26.8
27
*
CKC30
NOMESCO Finland
Cryopexy of detached retina
+∞
23.0
22
*
XCD10
NOMESCO Finland
Electrophysiological examination of eye
4.0
22.9
66
170
Z2221
NOMESCO Finland
Medical doctor
1.7
22.7
584
3929
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
2.9
22.6
107
378
H3600, E113,
ICD-10 Finland
+∞
21.9
21
*
S01EC01
ATC
acetazolamide; systemic
4.1
21.3
59
148
Z3231
NOMESCO Finland
Registered nurse
1.6
21.1
603
4154
S01EE01
ATC
latanoprost; ophthalmic
2.2
21.1
182
858
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
4.9
20.6
45
93
S01ED01
ATC
timolol; ophthalmic
2.9
20.5
97
343
XCW10
NOMESCO Finland
Assessment of vision
5.1
19.8
41
81
ZXD10
NOMESCO Finland
Scheduled procedure
1.5
19.6
840
6335
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
8.4
19.3
25
30
H35.9
ICD-10 Finland
Retinal disorder, unspecified
31.6
19.3
25
8
S01EA03
ATC
apraclonidine; ophthalmic
7.0
19.1
29
42
H25.8
ICD-10 Finland
Other senile cataract
1.8
18.6
300
1761
CM2X4
NOMESCO Finland
Follow-up OCT of age-related macular degeneration lesions
44.4
18.2
22
5
H36.01
ICD-10 Finland
Diabetic maculopathy
44.4
18.2
22
5
CKC60
NOMESCO Finland
Local buckling of sclera using implant
+∞
17.7
17
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
5.5
17.1
33
61
S01EA05
ATC
brimonidine; ophthalmic
3.1
17.1
73
244
CM2S4
NOMESCO Finland
Follow-up photography of age-related macular degeneration lesions
50.4
17.0
20
*
XCK00
NOMESCO Finland
Perimetry
2.2
16.7
149
712
TCG40
NOMESCO Finland
Measurement of higher-grade errors of refraction
15.5
16.2
26
17
H36.00
ICD-10 Finland
Diabetic background retinopathy
30.3
16.1
21
7
H20.1
ICD-10 Finland
Chronic iridocyclitis
6.0
16.1
28
47
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
47.9
16.0
19
*
CKC70
NOMESCO Finland
Circular buckling of sclera
+∞
15.6
15
*
CKD50
NOMESCO Finland
Endodiathermy of retina
+∞
15.6
15
*
114
Kela drug reimbursment
Glaucoma
1.9
15.4
224
1272
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
45.3
15.1
18
*
H35.4
ICD-10 Finland
Peripheral retinal degeneration
57.1
14.8
17
*
S01EC04
ATC
brinzolamide; ophthalmic
2.3
14.7
111
495
H35.6
ICD-10 Finland
Retinal haemorrhage
80.7
14.6
16
*
F29
ICPC
Eye symptom/complaint other
1.8
13.8
201
1140
TCA20
NOMESCO Finland
Peribulbar therapeutic injection into orbit
17.7
13.8
21
12
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
140.9
13.5
14
*
H26.02
ICD-10 Finland
Presenil cataract
2.9
13.3
62
218
H40.0
ICD-10 Finland
Glaucoma suspect
1.8
13.2
189
1066
WX110
NOMESCO Finland
Infiltration anesthesia
1.4
12.8
1353
11752
S01EE05
ATC
tafluprost; ophthalmic
2.2
12.7
103
474
CA1TM
NOMESCO Finland
Calculation of intraocular lens power
3.0
12.6
56
192
S01BC03
ATC
diclofenac; ophthalmic
3.2
12.5
50
161
H3600, E103,
ICD-10 Finland
+∞
12.5
12
*
H3603, E113,
ICD-10 Finland
+∞
12.5
12
*
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
2.1
12.2
122
609
F05
ICPC
Visual disturbance other
2.5
11.9
71
285
H52.1
ICD-10 Finland
Myopia
3.0
11.8
51
172
Z71.8
ICD-10 Finland
Other specified counselling
1.4
11.6
562
4244
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
12.6
11.6
20
16
Z3229
NOMESCO Finland
Other healthcare associate professional
1.8
11.5
173
991
S01EC54
ATC
brinzolamide, combinations; ophthalmic
3.3
11.5
42
128
H26.8
ICD-10 Finland
Other specified cataract
4.0
11.5
32
81
H3603, E103,
ICD-10 Finland
+∞
11.5
11
*
H34.1
ICD-10 Finland
Central retinal artery occlusion
+∞
11.5
11
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
8.4
11.3
24
29
S01EE04
ATC
travoprost; ophthalmic
2.7
10.8
57
215
D31.3
ICD-10 Finland
Benign neoplasm: Choroid
3.1
10.7
43
139
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
5.0
10.5
22
44
CS1H4
NOMESCO Finland
Retinal nerve fibre layer imaging
2.6
10.5
58
224
H40.11
ICD-10 Finland
Low pressure glaucoma
2.5
10.3
63
256
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
2.3
10.1
76
340
CJ2M4
NOMESCO Finland
Scans and measurement printouts for intraocular lens power calculation
3.4
9.7
34
101
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
4.6
9.5
22
48
CK2Y4
NOMESCO Finland
OCT video recording of ocular fundus
100.5
9.4
10
*
H33.1
ICD-10 Finland
Retinoschisis and retinal cysts
100.5
9.4
10
*
3610A
ICD-9 Finland
Retinal detachments and defects, Retinal detachment with retinal defect
+∞
9.4
9
*
H3601, E103,
ICD-10 Finland
+∞
9.4
9
*
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
8.1
9.3
20
25
CA1ME
NOMESCO Finland
Ultrasound oculometry
4.7
9.3
21
45
F28
ICPC
Limited function/disability (F)
5.0
9.1
19
38
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
2.5
9.1
57
235
N02BE01
ATC
paracetamol; systemic, rectal
1.5
8.9
1861
17495
F43
ICPC
Eye, Other diagnostic procedure
2.6
8.8
50
196
R42
ICD-10 Finland
Dizziness and giddiness
1.4
8.8
483
3706
F99
ICPC
Eye/adnexa disease other
4.3
8.7
22
52
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
6.6
8.7
21
32
H33
ICD-10 Finland
Retinal detachments and breaks
27.6
8.5
11
*
CKC15
NOMESCO Finland
Panretinal photocoagulation
20.1
8.5
12
6
H34.2
ICD-10 Finland
Other retinal artery occlusions
90.4
8.4
9
*
WX144
NOMESCO Finland
Subconjunctival anesthesy
3.2
8.4
32
101
H31.0
ICD-10 Finland
Chorioretinal scars
+∞
8.3
8
*
H33.4
ICD-10 Finland
Traction detachment of retina
+∞
8.3
8
*
H35
ICD-10 Finland
Other retinal disorders
22.1
8.0
11
5
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
2.0
7.9
84
430
E0000UV, ,
ATC
1.3
7.9
780
6518
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
3.7
7.9
24
65
H54.7
ICD-10 Finland
Unspecified visual loss
6.1
7.8
20
33
ZX198
NOMESCO Finland
Other local administration
6.4
7.7
19
30
H54.6
ICD-10 Finland
Moderate visual impairment, monocular
8.1
7.6
16
20
S01EC03
ATC
dorzolamide; ophthalmic
2.9
7.5
35
124
H43.3
ICD-10 Finland
Other vitreous opacities
3.1
7.4
30
98
CKW99
NOMESCO Finland
Other operation on choroid, vitreous body and retina
80.4
7.4
8
*
CK9G4
NOMESCO Finland
Iridocyanine green angiography (ICGA) of choroid and retina
80.4
7.4
8
*
H33.5
ICD-10 Finland
Other retinal detachments
7.7
7.4
16
21
H57.1
ICD-10 Finland
Ocular pain
2.2
7.3
62
292
H30.2
ICD-10 Finland
Posterior cyclitis
+∞
7.3
7
*
1LA05, ,
NOMESCO Finland
+∞
7.3
7
*
CKD91, ,
SPAT
+∞
7.3
7
*
H53.8
ICD-10 Finland
Other visual disturbances
2.9
7.3
32
110
S18
ICPC
Laceration/cut
1.3
7.3
954
8251
H44.2
ICD-10 Finland
Degenerative myopia
15.8
7.2
11
7
CH2X4
NOMESCO Finland
Optical coherence tomography (OCT) of iris and iridocorneal angle
30.1
7.1
9
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
12.1
7.1
12
10
UJF32
NOMESCO Finland
Coloscopy
1.3
7.0
557
4505
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
2.7
6.8
36
137
H54.5
ICD-10 Finland
Severe visual impairment, monocular
6.7
6.8
16
24
S01EE03
ATC
bimatoprost; ophthalmic
2.2
6.8
55
255
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.3
6.7
606
4983
F13
ICPC
Eye sensation abnormal
2.2
6.7
53
244
R4110
NOMESCO Finland
Physiotherapy
1.3
6.6
557
4536
H36.09*E11.3
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic retinopathy
12.3
6.6
11
9
WX402
NOMESCO Finland
General anaesthesia
1.4
6.4
372
2865
Z01.7
ICD-10 Finland
Laboratory examination
1.4
6.4
268
1954
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.5
6.4
227
1605
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.4
6.4
317
2381
J01DB01
ATC
cefalexin; oral
1.3
6.4
1600
14878
R53
ICD-10 Finland
Malaise and fatigue
1.3
6.3
422
3320
3625D
ICD-9 Finland
Other retinal disorders, Degeneration of macula and posterior pole[CYSTA MACULAE (""""MACULAR HOLE"""")]
+∞
6.3
6
*
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.3
6.2
484
3898
C08CA10
ATC
nilvadipine; oral
2.3
6.1
44
194
TPH04
NOMESCO Finland
Cathetrisation of vein
1.3
6.1
436
3462
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
6.1
1258
11384
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
6.7
6.0
14
21
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
2088
19360
5.18
28.89
27.1
24.4
132.96
132.85
g/l
0.12
2053
19006
2087
19354
5.07
28.65
26.9
24.3
6.74
6.75
e9/l
0.07
2014
18676
2087
19355
5.06
28.63
26.9
24.3
245.60
247.03
e9/l
0.45
2029
18759
2087
19358
5.05
28.56
26.9
24.3
4.40
4.40
e12/l
0.22
2014
18676
2085
19347
4.84
28.06
27.0
24.3
39.60
39.40
%
0.68
1917
17789
1985
18052
2.48
25.30
5.8
5.5
2.62
2.67
mmol/l
1.51
1804
16258
2049
18936
3.21
25.09
21.0
19.2
139.66
139.68
mmol/l
0.18
2005
18446
2047
18928
3.14
24.63
12.6
11.5
23.44
24.64
u/l
3.41
1966
18102
2050
18972
3.20
24.61
21.4
19.4
3.98
3.98
mmol/l
0.30
2001
18457
1930
17588
2.05
20.58
5.1
4.8
4.54
4.60
mmol/l
1.50
1764
15932
1706
15009
1.69
20.08
22.4
19.5
15.17
15.46
%
1.16
1672
14726
1882
17053
1.90
19.69
6.9
6.3
40.66
40.23
mmol/mol
1.24
1726
15479
1944
17810
2.06
19.65
5.4
5.1
6.04
6.01
mmol/l
0.48
1753
15919
1941
17777
2.05
19.57
18.1
16.3
24.37
25.58
mg/l
0.82
1572
14299
1841
16649
1.78
18.28
5.2
5.0
2.00
2.10
mu/l
0.70
1663
14905
1863
17007
1.77
16.56
17.7
15.6
73.09
74.27
ml/min/173m2
1.93
1570
14045
1895
17425
1.80
15.88
5.1
4.8
1.51
1.50
mmol/l
0.31
1716
15670
900
7109
1.46
15.67
3.1
2.8
140.09
150.05
ug/l
0.71
819
6432
1830
16806
1.63
13.65
4.5
4.3
1.28
1.28
mmol/l
0.01
1641
14929
1548
13745
1.46
13.23
4.6
4.3
14.20
14.06
mm/h
0.13
1428
12610
1557
13881
1.45
12.68
4.1
4.1
15.00
15.06
pmol/l
0.41
1374
12369
845
6839
1.39
11.80
4.3
3.8
102.59
121.40
e6/l
0.35
594
4918
701
5498
1.41
11.77
3.6
3.2
0.52
0.48
e6/l
0.17
536
4207
1635
14808
1.45
11.43
8.2
7.8
79.40
79.96
u/l
0.14
1526
13873
1431
12666
1.40
11.34
5.2
5.0
103.56
1812.42
e6/l
—
9
186
747
5953
1.39
11.32
3.8
3.3
127.52
79.24
e6/l
0.26
565
4598
1017
8562
1.36
10.79
2.2
2.1
94.63
94.52
pmol/l
0.02
519
4224
1197
10354
1.36
10.56
6.4
6.7
1.22
1.22
mmol/l
0.04
1027
8771
955
7980
1.36
10.55
11.6
10.2
0.00
0.00
e9/l
1.02
801
6443
1299
11408
1.36
10.21
4.9
4.6
6.82
6.72
mmol/l
0.96
1229
10749
1035
8820
1.34
9.76
4.6
4.7
34.99
34.93
g/l
0.12
966
8170
418
3083
1.44
9.60
2.9
2.6
12.11
12.44
umol/l
0.43
391
2881
540
4192
1.39
9.22
2.8
2.6
4.97
5.54
e6/l
0.57
467
3769
1225
10748
1.33
9.21
9.5
9.1
4.26
4.13
e9/l
1.03
1078
9308
1097
9477
1.33
9.19
5.9
5.9
1.21
1.21
mmol/l
0.28
990
8594
386
2844
1.44
8.85
3.0
2.6
2.28
2.28
g/l
0.01
352
2626
1039
8936
1.32
8.85
4.1
4.1
0.00
0.00
estimate
0.99
228
1800
369
2697
1.45
8.84
3.0
2.6
22.12
22.15
%
0.01
322
2293
627
5013
1.36
8.84
1.7
1.6
20.89
20.98
nmol/l
0.05
532
4214
1050
9067
1.31
8.59
4.1
4.1
0.00
0.00
estimate
0.80
204
1631
623
4995
1.35
8.57
2.5
2.2
3.05
3.08
mg/l
0.09
538
4208
1036
8950
1.31
8.36
5.6
5.4
0.00
0.00
estimate
-0.00
211
1664
932
7941
1.31
8.31
2.3
2.2
80.75
80.10
nmol/l
0.27
807
6957
514
4018
1.37
8.28
4.2
3.9
214.82
598.25
ng/l
1.02
437
3387
582
4659
1.34
8.00
4.8
4.7
22.00
21.72
%
0.18
314
2467
633
5150
1.33
7.74
1.7
1.6
1.34
1.34
mmol/l
0.02
500
4271
428
3301
1.37
7.42
3.2
3.3
0.80
0.79
ug/l
0.10
322
2380
767
6449
1.30
7.27
3.3
3.1
1678.07
1460.75
ng/l
0.61
661
5591
1100
9683
1.28
7.27
16.6
17.2
1.31
1.33
inr
0.15
324
2712
988
8602
1.28
7.05
6.9
5.9
58.21
57.64
%
0.75
920
7986
403
3103
1.37
7.03
2.1
2.0
30.13
29.97
s
0.20
389
2996
600
4902
1.31
7.00
4.5
3.9
86.97
87.83
%
0.36
583
4781
412
3191
1.36
6.91
3.4
3.0
1.82
2.69
e6/l
1.51
234
1745
434
3422
1.34
6.43
3.2
2.8
1.38
1.26
e6/l
0.15
258
1960
996
8751
1.26
6.35
7.2
6.1
26.50
27.04
%
0.81
928
8135
500
4031
1.31
6.33
2.9
3.2
2.47
2.47
mmol/l
0.23
444
3532
688
5787
1.28
6.30
5.6
5.5
2.56
3.45
ug/l
1.82
610
5102
967
8486
1.26
6.16
2.3
2.3
—
—
—
0
0
727
6192
1.26
5.93
2.2
2.2
163.04
227.28
u/l
2.31
662
5775
319
2447
1.36
5.63
2.5
2.5
1.76
1.82
%
0.46
273
2170
721
6164
1.26
5.63
3.3
3.2
400.09
349.28
mg/l
0.10
454
3837
431
3461
1.31
5.55
1.3
1.2
0.90
1.39
u/ml
1.38
108
834
729
6253
1.25
5.50
3.3
3.1
7.00
6.99
mmol/l
0.03
593
5195
804
6997
1.24
5.27
3.3
3.5
2.36
2.36
mmol/l
0.33
709
6026
284
2187
1.34
4.88
5.4
6.9
95.79
95.60
%
0.28
276
2097
28
113
2.50
4.79
1.3
1.2
15.74
17.64
u/l
0.18
23
99
654
5626
1.23
4.65
2.9
3.3
33.44
35.61
u/l
0.30
612
5311
381
3078
1.29
4.63
1.6
1.5
2.56
2.61
g/l
0.12
219
1706
746
6512
1.22
4.60
4.0
3.7
6.90
8.12
mg/mmol
0.52
452
3985
158
1113
1.45
4.59
6.4
8.3
24.11
24.47
mmol/l
0.79
152
1083
310
2442
1.32
4.55
5.3
6.6
0.71
1.20
mmol/l
1.41
257
1936
182
1319
1.42
4.54
6.8
7.9
0.62
0.67
%
1.16
182
1310
1159
10578
1.21
4.50
3.3
3.2
50.46
54.30
u/l
0.58
1060
9574
183
1330
1.41
4.49
6.7
7.8
1.30
1.31
%
0.02
183
1322
240
1826
1.35
4.46
5.3
6.1
1.29
1.36
mmol/l
0.66
234
1782
76
456
1.69
4.46
2.5
2.1
65.73
91.95
ug/min
0.36
42
271
309
2440
1.31
4.46
5.3
6.6
5.08
5.11
kpa
0.26
296
2322
309
2440
1.31
4.46
5.3
6.6
11.96
12.11
kpa
0.17
297
2322
1129
10287
1.21
4.43
6.0
6.4
11.40
11.63
umol/l
0.22
1061
9758
232
1761
1.36
4.38
2.4
2.3
30.43
37.38
u/l
2.14
199
1512
32
147
2.19
4.15
3.0
2.2
627.57
626.66
ml
0.00
21
101
360
2927
1.28
4.15
1.3
1.3
62.41
41.48
iu/ml
1.06
114
933
487
4108
1.24
4.08
1.8
1.8
1179.07
1163.78
nmol/l
0.13
350
3059
242
1877
1.33
3.97
2.7
2.5
69.09
68.93
e9/l
0.02
183
1428
268
2120
1.30
3.82
3.5
3.7
—
—
—
0
0
256
2014
1.31
3.80
5.7
7.3
119.31
120.40
g/l
0.38
251
1950
40
208
1.94
3.78
1.2
1.2
46.85
56.43
u/l
1.49
34
191
108
737
1.49
3.73
1.8
1.7
41.57
39.13
u/l
0.54
95
638
566
4893
1.21
3.70
4.4
4.5
0.00
0.00
estimate
0.50
202
1593
179
1342
1.36
3.68
3.5
2.8
10.53
10.49
g/l
0.04
168
1206
268
2134
1.29
3.63
2.9
2.6
7.41
8.57
umol/l
0.52
225
1864
569
4949
1.20
3.47
2.9
2.8
3652.17
5794.03
umol/l
0.71
473
4252
299
2430
1.27
3.45
4.9
4.4
245.81
248.35
u/l
0.06
277
2279
459
3915
1.22
3.41
2.1
1.8
1.03
1.41
mg/l
3.37
351
3058
300
2443
1.27
3.40
1.3
1.3
—
—
—
0
0
124
893
1.41
3.27
1.9
2.1
11.49
12.12
nmol/l
0.28
107
771
289
2363
1.26
3.17
1.9
1.8
—
—
—
0
0
844
7658
1.17
3.07
4.2
3.9
32.67
108.22
ng/l
0.77
642
5765
970
8899
1.17
3.06
2.7
2.7
—
—
—
0
0
748
6724
1.17
3.06
4.5
4.4
—
—
—
0
0
26
127
2.06
2.97
1.3
1.6
—
—
—
0
0
73
485
1.52
2.93
1.6
1.5
0.31
13.10
iu/ml
0.56
17
103
506
4416
1.19
2.92
1.8
1.7
16071888.40
23582195.66
pmol/l
0.17
392
3596
23
109
2.12
2.84
1.3
1.6
—
—
—
0
0
23
109
2.12
2.84
1.3
1.6
—
—
—
0
0
140
1057
1.35
2.81
2.2
1.8
1.45
1.51
g/l
0.11
126
939
103
742
1.41
2.76
3.5
3.6
35.22
67.96
mg/l
1.09
81
604
232
1884
1.26
2.72
3.9
3.4
5.72
5.84
kpa
1.16
222
1832
9
24
3.76
2.67
1.0
1.1
—
—
—
0
0
285
2381
1.23
2.59
1.9
1.8
—
—
—
0
0
102
745
1.39
2.54
3.5
3.6
63.20
137.32
mg/l
0.48
78
608
194
1556
1.27
2.53
3.1
2.8
4.68
4.50
kpa
0.45
187
1510
240
1974
1.24
2.53
3.0
2.9
191.82
209.32
ng/l
0.30
223
1816
229
1875
1.25
2.51
3.9
3.4
1.39
2.11
mmol/l
1.85
194
1606
382
3321
1.18
2.29
3.0
3.1
0.81
0.81
mmol/l
0.20
351
3099
97
722
1.36
2.20
3.3
3.6
17.52
1.44
ratio
—
8
49
326
2807
1.19
2.18
1.3
1.2
11.47
14.78
u/ml
0.40
123
979
130
1012
1.30
2.17
3.4
3.1
4.43
4.37
pmol/l
0.24
115
879
312
2677
1.19
2.17
5.9
5.4
1.02
1.03
mmol/l
0.32
287
2462
80
578
1.40
2.17
1.5
1.4
275.73
278.53
ug/g
0.04
49
343
6
14
4.29
2.15
1.0
1.0
—
—
—
0
0
102
770
1.34
2.12
2.6
2.6
0.55
1.09
g/l
1.00
80
666
49
325
1.52
2.07
1.2
1.5
—
—
—
0
0
145
1157
1.27
2.02
1.4
1.5
—
—
—
0
0
40
256
1.57
1.98
1.3
1.5
—
—
—
0
0
48
321
1.51
1.96
4.1
5.2
105.60
868.13
iu/ml
—
5
48
50
338
1.49
1.95
1.4
1.2
21.65
53.11
u/ml
—
6
35
660
6041
1.13
1.94
2.5
2.5
54.40
73.22
u/l
0.79
596
5521
234
1979
1.20
1.92
2.1
2.1
0.21
0.21
g/l
0.52
209
1841
64
459
1.41
1.85
1.9
1.8
12.33
12.22
mg/l
0.04
58
416
53
367
1.46
1.85
1.1
1.3
—
382.50
—
0
8
83
628
1.33
1.75
1.3
1.2
0.29
0.82
u/ml
—
8
52
217
1842
1.20
1.73
2.5
2.8
66.31
66.16
g/l
0.10
197
1674
217
1843
1.20
1.72
7.6
6.9
9.71
10.37
mmol/l
0.78
207
1746
61
442
1.39
1.69
1.4
1.2
1.84
4.09
u/ml
1.16
11
43
20
111
1.81
1.68
1.2
1.5
—
—
—
0
0
20
111
1.81
1.68
1.2
1.5
—
—
—
0
0
62
451
1.39
1.68
1.2
1.3
—
—
—
0
0
61
445
1.38
1.63
1.5
1.3
—
—
—
0
0
61
445
1.38
1.63
1.5
1.3
—
—
—
0
0
34
221
1.55
1.62
1.5
1.7
—
—
—
0
0
5
14
3.58
1.61
1.0
1.2
—
—
—
0
0
523
4777
1.13
1.57
2.5
2.4
—
—
—
0
0
138
1133
1.23
1.56
2.5
2.5
31.74
25.22
au/ml
—
5
56
61
449
1.37
1.56
1.4
1.2
4.50
8.35
u/ml
0.60
14
74
105
838
1.27
1.52
1.9
2.6
2.95
2.97
g/l
0.06
90
750
158
1321
1.21
1.50
1.8
1.7
—
—
—
0
0
86
671
1.29
1.49
2.0
2.5
0.11
0.03
g/l
0.34
76
618
75
575
1.32
1.48
1.5
1.7
—
—
—
0
0
35
235
1.50
1.47
1.3
1.1
328.48
298.80
u/ml
0.27
23
134
46
327
1.42
1.45
1.2
1.2
—
—
—
0
0
112
907
1.25
1.45
1.3
1.2
151.58
186.01
u/ml
0.54
105
828
194
1660
1.19
1.45
2.2
2.2
379.40
370.84
nmol/l
0.23
172
1503
51
371
1.38
1.42
1.5
1.3
—
—
—
0
0
23
141
1.64
1.41
1.6
1.7
—
—
—
0
0
203
1748
1.18
1.41
3.6
3.9
1.23
1.23
mmol/l
0.07
165
1539
67
510
1.32
1.40
1.9
2.4
3.84
3.60
g/l
0.72
62
484
51
373
1.38
1.38
1.4
1.2
19.40
5.03
u/ml
—
6
27
21
128
1.65
1.33
1.6
1.6
7.67
7.42
u/l
0.03
15
109
37
258
1.44
1.31
1.2
1.1
—
—
—
0
0
63
482
1.32
1.29
1.5
1.5
—
—
—
0
0
234
2654
0.87
1.28
5.5
4.8
33.12
33.41
%
0.17
165
1702
375
3402
1.12
1.27
1.9
1.9
—
—
—
0
0
208
1814
1.16
1.26
2.4
2.4
5.48
7.28
ug/l
1.85
181
1585
109
897
1.23
1.25
1.9
2.6
—
—
—
0
0
109
897
1.23
1.25
1.9
2.6
7.63
7.44
g/l
0.61
95
808
67
520
1.30
1.25
2.0
1.7
—
—
—
0
0
31
212
1.47
1.23
1.7
1.5
—
—
—
0
0
30
432
0.69
1.22
5.0
3.6
32.21
27.81
mg/l
0.17
19
262
25
164
1.53
1.20
1.4
1.7
—
—
—
0
0
270
2411
1.14
1.18
3.5
4.1
8.05
20.03
ug/l
1.86
228
1996
87
704
1.25
1.18
2.1
2.4
36.68
37.54
g/l
0.68
72
616
108
895
1.22
1.17
1.9
2.6
3.89
3.59
g/l
0.93
95
808
113
941
1.21
1.17
2.7
2.3
0.65
0.64
%
0.09
113
935
20
126
1.59
1.14
1.2
1.1
—
—
—
0
0
89
726
1.24
1.13
2.5
2.8
—
—
—
0
0
171
1489
1.16
1.08
1.6
1.6
—
—
—
0
0
114
959
1.20
1.08
2.7
2.3
1.00
1.11
%
1.43
114
953
35
253
1.39
1.06
1.3
1.1
—
—
—
0
0
121
1027
1.19
1.05
1.3
1.4
33.28
58.61
au/ml
—
6
59
15
90
1.67
1.04
1.7
1.2
1.21
1.18
nmol/l
—
9
72
39
289
1.36
1.03
1.3
1.5
—
—
—
0
0
16
98
1.64
1.03
1.7
1.5
1.36
2.42
u/field
0.75
11
64
26
179
1.46
1.03
1.0
1.1
0.83
2.00
u/ml
—
8
50
19
122
1.56
1.02
1.3
1.1
—
—
—
0
0
77
628
1.23
1.01
2.1
2.5
0.00
0.00
g/l
-0.00
68
578
100
838
1.20
1.00
2.0
2.6
10.01
10.15
g/l
0.12
86
744
21
139
1.52
1.00
1.2
1.4
—
—
—
0
0
20
131
1.53
1.00
1.1
1.1
—
—
—
0
0
20
131
1.53
1.00
1.1
1.1
—
—
—
0
0
76
620
1.23
0.99
2.1
2.5
0.00
0.00
g/l
-0.00
68
577
21
140
1.50
0.97
1.2
1.4
—
—
—
0
0
20
132
1.52
0.97
1.1
1.1
—
—
—
0
0
20
132
1.52
0.97
1.1
1.1
—
—
—
0
0
20
132
1.52
0.97
1.1
1.1
—
—
—
0
0
61
488
1.26
0.95
1.5
1.7
—
—
—
0
0
7
37
1.89
0.94
1.1
1.5
79.71
109.14
ng/l
—
7
37
36
269
1.34
0.92
1.5
1.6
—
—
—
0
0
25
350
0.71
0.92
1.5
1.4
—
—
—
0
0
10
55
1.82
0.92
1.4
1.1
—
—
—
0
0
6
28
2.15
0.91
1.0
1.1
—
—
—
0
0
34
254
1.34
0.88
1.3
1.5
—
—
—
0
0
190
1696
1.13
0.88
4.1
3.6
90.27
90.32
ng/l
0.00
155
1430
10
169
0.59
0.88
1.4
1.5
—
—
—
0
0
10
169
0.59
0.88
1.4
1.5
—
—
—
0
0
10
169
0.59
0.88
1.4
1.5
—
—
—
0
0
13
79
1.65
0.88
1.2
1.2
—
—
—
0
0
62
503
1.24
0.88
1.6
1.6
8111.56
14279.09
e6/l
1.43
45
359
160
1413
1.14
0.87
1.7
1.7
1.53
1.56
%
0.18
130
1168
31
229
1.36
0.86
4.5
3.9
—
—
—
0
0
6
31
1.94
0.84
1.2
1.0
—
—
—
0
0
8
45
1.78
0.84
1.8
1.8
—
—
—
0
0
64
525
1.23
0.83
1.4
1.6
—
—
—
0
0
8
46
1.74
0.82
1.4
1.3
—
—
—
0
0
66
544
1.22
0.82
1.4
1.4
—
—
—
0
0
16
237
0.67
0.82
2.4
3.6
60.63
57.42
%
0.29
16
198
6
32
1.88
0.81
1.3
1.2
—
—
—
0
0
425
3980
1.08
0.79
4.6
4.6
1.02
1.02
kg/l
0.96
78
626
5
100
0.50
0.77
1.6
1.6
—
—
—
0
0
5
100
0.50
0.77
1.6
1.6
—
—
—
0
0
63
521
1.22
0.77
1.2
1.1
—
—
—
0
0
6
34
1.77
0.76
1.2
1.2
—
—
—
0
0
62
514
1.21
0.74
1.2
1.1
—
—
—
0
0
32
246
1.31
0.72
2.1
1.3
100.63
130.85
u/ml
—
8
42
42
335
1.26
0.72
2.5
1.7
—
—
—
0
0
75
637
1.18
0.71
4.8
3.8
3.83
3.89
mmol/l
0.70
75
631
5
26
1.93
0.70
12.2
16.6
4.52
5.54
mmol/l
—
5
26
86
741
1.17
0.69
4.4
3.5
1.32
1.38
mmol/l
0.28
86
728
17
239
0.71
0.68
1.0
1.1
50.00
92.00
iu/ml
—
5
44
14
204
0.68
0.68
1.4
1.5
—
—
—
0
0
23
170
1.36
0.67
1.0
1.1
—
—
u/ml
—
0
0
15
102
1.47
0.67
3.5
2.4
29.25
39.20
%
—
8
63
36
285
1.27
0.66
1.9
1.2
—
20.53
—
0
5
13
191
0.68
0.66
1.4
1.6
—
—
—
0
0
22
290
0.76
0.61
3.5
2.2
29.22
22.87
mg/l
—
8
61
30
235
1.28
0.61
3.2
4.5
337.57
368.76
umol/l
0.41
24
203
9
138
0.65
0.60
1.0
1.1
—
—
—
0
0
13
88
1.48
0.60
1.0
1.0
—
—
—
0
0
100
883
1.14
0.60
3.0
5.0
1.53
1.56
%
0.19
94
819
8
51
1.57
0.60
1.0
1.2
—
—
—
0
0
32
400
0.80
0.60
2.3
3.8
29.83
36.28
u/ml
0.29
32
390
0
22
0.00
0.59
0.0
1.3
—
14.09
—
0
22
8
53
1.51
0.58
1.3
1.4
10.15
9.22
ug/l
—
8
53
34
420
0.81
0.58
1.6
1.5
242.26
274.47
pmol/l
0.08
34
410
7
116
0.60
0.57
1.6
1.8
—
—
—
0
0
12
81
1.48
0.57
1.0
1.0
2.92
13.72
iu/ml
—
5
28
6
36
1.67
0.56
1.0
1.1
—
6.03
—
0
6
8
55
1.46
0.56
1.0
1.4
—
—
—
0
0
62
532
1.17
0.56
2.6
3.1
0.72
0.81
nmol/l
1.38
49
419
70
805
0.87
0.56
1.7
1.8
—
—
—
0
0
148
1347
1.11
0.55
6.0
6.5
24.76
24.65
mmol/l
0.16
143
1274
15
107
1.40
0.55
1.3
1.4
—
—
—
0
0
15
107
1.40
0.55
1.3
1.4
—
—
—
0
0
19
142
1.34
0.54
1.0
1.1
0.51
0.97
u/ml
0.50
11
75
26
204
1.28
0.54
1.2
1.2
4.23
5.69
u/ml
0.28
13
91
41
341
1.21
0.52
1.4
1.7
—
—
—
0
0
77
872
0.88
0.51
1.7
1.9
—
—
—
0
0
9
65
1.39
0.50
2.4
2.7
—
—
—
0
0
9
65
1.39
0.50
2.4
2.7
—
—
—
0
0
21
162
1.30
0.50
1.9
1.9
2.78
1.71
u/field
—
9
52
26
207
1.26
0.49
1.3
1.2
11.91
12.17
u/l
0.02
21
161
18
136
1.33
0.49
1.2
1.2
—
—
—
0
0
49
418
1.18
0.49
2.4
2.5
33.63
33.85
umol/l
0.02
38
369
78
691
1.13
0.48
1.3
1.2
—
—
—
0
0
19
147
1.30
0.45
1.4
1.3
—
—
—
0
0
10
69
1.45
0.44
1.1
1.5
—
—
—
0
0
16
207
0.77
0.42
1.3
1.4
264.82
276.12
mosm/kgh2o
1.16
11
153
27
221
1.22
0.42
3.6
5.4
7.02
7.37
mmol/l
0.33
22
189
111
1015
1.10
0.41
3.4
3.1
25.34
25.37
mmol/l
0.03
105
984
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
196
1838
1.07
0.41
2.5
2.0
152.77
146.09
ug/g
0.10
152
1426
11
79
1.39
0.40
1.4
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
1.4
—
—
—
0
0
53
464
1.15
0.40
3.7
2.7
1.80
1.68
mg/l
0.25
44
425
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
9.64
—
0
18
7
103
0.68
0.39
1.6
3.4
—
—
—
0
0
10
71
1.41
0.39
1.2
1.3
115.10
155.73
mmol/24h
—
10
71
72
647
1.12
0.38
1.2
1.3
—
—
—
0
0
35
299
1.17
0.37
1.0
1.1
—
—
—
0
0
8
115
0.69
0.37
2.3
2.3
—
—
—
0
0
26
311
0.83
0.37
1.5
1.5
—
—
—
0
0
26
311
0.83
0.37
1.5
1.5
—
—
—
0
0
22
267
0.82
0.36
1.3
1.4
—
—
—
0
0
50
441
1.14
0.36
4.1
3.3
7.25
7.51
mmol/l
0.19
50
432
6
43
1.40
0.35
2.3
1.2
—
—
—
0
0
29
246
1.18
0.34
1.3
1.5
44.26
61.79
%
1.35
19
152
21
254
0.83
0.34
1.5
1.4
24144.20
61437.96
e6/l
—
10
145
49
434
1.13
0.33
1.8
1.6
—
—
—
0
0
24
286
0.84
0.33
8.8
6.6
12.58
12.33
mg/l
0.13
24
267
15
188
0.80
0.33
1.5
1.3
—
—
—
0
0
110
1020
1.08
0.33
3.1
2.8
0.21
0.34
e6/l
0.89
110
999
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
84
771
1.09
0.32
2.7
3.0
0.31
0.35
u/ml
0.64
41
456
95
879
1.08
0.30
1.7
2.0
3.53
2.11
ug/l
0.49
84
776
7
55
1.27
0.30
1.4
1.2
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
13
102
1.28
0.30
1.1
1.1
—
—
—
0
0
51
458
1.12
0.29
2.9
2.2
120.72
125.61
g/l
0.61
36
324
110
1026
1.08
0.29
1.6
1.8
1.42
1.57
g/l
1.13
94
882
51
459
1.11
0.28
1.3
1.4
—
—
—
0
0
14
112
1.25
0.28
1.1
1.5
80.57
87.88
umol/l
0.52
14
112
40
355
1.13
0.28
3.1
3.0
3.76
4.17
e9/l
0.75
40
355
31
270
1.15
0.28
1.5
1.4
—
—
—
0
0
10
128
0.78
0.26
1.0
1.2
1.76
2.07
mmol/l
—
10
119
50
453
1.11
0.26
1.5
1.6
—
—
—
0
0
5
75
0.67
0.25
1.0
1.3
—
—
—
0
0
41
368
1.12
0.25
3.3
3.1
55.80
57.54
%
0.41
41
368
25
217
1.15
0.24
1.2
1.2
5.80
3.87
u/ml
—
10
67
31
274
1.13
0.24
1.5
1.4
—
—
—
0
0
6
84
0.71
0.24
1.0
1.2
—
—
—
0
0
24
209
1.15
0.23
1.1
1.0
—
—
—
0
0
31
276
1.13
0.22
1.5
1.4
—
—
—
0
0
253
2616
0.96
0.21
8.3
7.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
2.60
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
17
145
1.17
0.20
1.1
1.0
—
—
—
0
0
10
80
1.25
0.20
1.2
1.3
—
—
—
0
0
18
208
0.86
0.20
3.9
2.9
—
—
—
0
0
20
229
0.87
0.20
1.4
1.3
134.00
199.69
miu/ml
0.67
11
71
30
269
1.12
0.19
1.5
1.4
—
—
—
0
0
87
821
1.06
0.19
1.8
1.8
—
—
—
0
0
127
1213
1.05
0.19
4.1
3.5
1.79
2.06
mmol/l
0.41
98
913
30
270
1.11
0.19
1.5
1.4
—
—
—
0
0
6
53
1.13
0.18
1.3
1.7
79.17
214.21
nmol/24h
—
6
53
12
100
1.20
0.18
1.0
1.0
—
—
—
0
0
50
464
1.08
0.18
4.1
3.2
1.63
1.56
mmol/l
0.22
50
456
30
272
1.10
0.17
1.5
1.4
—
—
—
0
0
9
82
1.10
0.15
1.2
1.1
—
—
—
0
0
38
353
1.08
0.14
1.3
1.3
—
—
—
0
0
50
470
1.07
0.14
1.5
1.6
—
—
—
0
0
8
96
0.83
0.13
1.1
1.0
—
—
—
0
0
8
97
0.82
0.13
1.0
1.3
—
—
—
0
0
8
99
0.81
0.13
4.0
4.0
13.49
13.36
%
—
8
99
22
200
1.10
0.12
1.2
1.1
—
16.51
—
0
8
40
377
1.06
0.11
1.5
1.3
854.11
904.20
e6/l
0.02
27
305
40
377
1.06
0.11
1.4
1.3
4.54
35.88
e6/l
1.20
26
286
5
45
1.11
0.09
2.6
2.9
207.20
201.53
%
—
5
40
5
45
1.11
0.09
1.4
1.1
756.40
1485.29
miu/ml
—
5
45
15
166
0.90
0.09
1.9
1.6
32.60
25.17
u/ml
—
5
30
10
87
1.15
0.09
2.0
1.2
32.02
2.70
u/l
—
5
31
22
204
1.08
0.08
1.0
1.1
—
—
—
0
0
55
528
1.04
0.08
1.3
1.2
—
—
—
0
0
6
58
1.03
0.08
1.3
1.9
1.65
0.82
mmol/l
—
6
53
131
1280
1.02
0.08
4.1
3.6
5.12
5.15
kpa
0.16
122
1213
5
63
0.79
0.08
1.2
1.2
—
—
—
0
0
13
117
1.11
0.08
1.3
1.3
—
—
—
0
0
18
195
0.92
0.08
1.3
1.4
2812.64
93645.49
e6/l
1.38
11
134
42
401
1.05
0.08
1.6
1.7
5.65
4.06
iu/l
0.62
12
115
7
67
1.04
0.08
1.1
1.1
—
—
—
0
0
48
461
1.04
0.07
1.9
1.8
2.96
4.37
mg/l
0.55
38
366
17
184
0.92
0.07
1.8
2.2
—
—
—
0
0
8
77
1.04
0.07
1.4
1.5
1.63
1.59
g/l
—
8
77
50
481
1.04
0.07
2.9
6.9
103.82
105.26
mmol/l
1.05
45
424
22
206
1.07
0.07
1.1
1.3
397.00
332.48
u/l
0.40
22
199
34
356
0.95
0.06
2.6
1.9
1.58
1.64
mmol/l
0.17
34
348
16
148
1.08
0.06
5.9
4.9
12.26
37.53
u/ml
—
5
41
27
284
0.95
0.06
1.4
1.4
1302.95
1779.05
e6/l
0.63
19
202
13
141
0.92
0.05
2.2
2.3
—
—
—
0
0
43
445
0.97
0.05
1.4
1.3
—
—
—
0
0
76
743
1.02
0.05
1.9
2.3
459.44
837.00
ug/l
0.50
71
702
12
110
1.09
0.05
1.7
1.5
0.93
0.98
g/l
0.31
12
110
11
120
0.92
0.05
2.2
1.9
—
—
—
0
0
81
827
0.98
0.04
3.3
3.3
2780.89
2000.73
u/ml
0.10
72
699
191
1932
0.99
0.04
1.3
1.3
—
—
—
0
0
21
221
0.95
0.04
1.3
1.4
6.00
6.51
mmol/l
0.36
21
207
24
229
1.05
0.04
2.0
3.3
8.06
5.06
nmol/l
0.36
24
223
17
160
1.06
0.04
1.0
1.0
345.36
306.77
ng/l
0.28
11
99
11
101
1.09
0.04
1.1
1.1
—
—
—
0
0
11
119
0.92
0.04
1.7
1.9
—
—
—
0
0
73
744
0.98
0.03
1.0
1.0
—
—
—
0
0
17
161
1.06
0.03
1.0
1.0
49.45
44.11
ng/l
0.18
11
99
46
449
1.03
0.03
3.5
2.6
14.90
15.51
%
0.39
23
218
37
360
1.03
0.03
1.1
1.1
—
—
—
0
0
17
162
1.05
0.02
1.0
1.0
744.36
714.57
ng/l
0.07
11
97
39
398
0.98
0.01
1.4
1.3
—
—
—
0
0
103
1021
1.01
0.01
1.2
1.2
175.82
141.35
iu/ml
0.24
28
360
14
146
0.96
0.00
1.0
1.2
—
—
—
0
0
18
186
0.97
0.00
1.2
1.5
51.14
30.82
%
—
7
115
10
105
0.95
0.00
5.5
3.9
—
—
—
0
0
19
189
1.01
0.00
1.1
1.1
—
—
—
0
0
11
112
0.98
0.00
1.0
1.2
—
—
—
0
0
21
212
0.99
0.00
1.5
1.5
—
—
—
0
0
21
212
0.99
0.00
1.5
1.5
—
—
—
0
0
157
1572
1.00
0.00
3.5
2.8
59.83
60.83
ml/min/173m2
0.13
75
672
20
203
0.99
0.00
1.2
1.2
—
—
—
0
0
25
247
1.01
0.00
2.3
1.9
4.43
1222.73
u/ml
0.60
25
241
0
8
0.00
-0.00
0.0
1.1
—
7.56
—
0
8
6
65
0.92
-0.00
1.2
1.4
50.50
28.98
%
—
6
41
9
89
1.01
-0.00
1.3
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
70
1.00
-0.00
1.0
1.0
—
—
—
0
0
11
110
1.00
-0.00
1.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
54
0.93
-0.00
1.0
1.1
157.64
228.22
iu/ml
—
5
54
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
66
0.91
-0.00
1.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint MACULAR_HOLE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| MACULAR_HOLE | 0.823 [0.69, 0.98] | 0.032 |
| Birth year | 0.998 [0.99, 1.01] | 0.693 |
During the follow-up period (1.1.1998 — 31.12.2019), 473 out of 5602 females with MACULAR_HOLE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| MACULAR_HOLE | 0.685 [0.56, 0.84] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 348 out of 3044 males with MACULAR_HOLE died.
Mortality risk
Mortality risk for people of age
years, who have MACULAR_HOLE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.057% | 0.114% |
| 5 | 0.428% | 0.742% |
| 10 | 1.293% | 2.0% |
| 15 | 2.573% | 3.641% |
| 20 | 4.578% | 6.087% |
Relationships between endpoints
↥Index endpoint: MACULAR_HOLE – Macular hole
GWS hits: 6
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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