Ulcerative enterocolitis

ULCERENTER

ulcerative colitis: An inflammatory bowel disease involving the mucosal surface of the large intestine and rectum. It may present with an acute or slow onset and follows an intermittent or continuous course. Signs and symptoms include abdominal pain, diarrhea, fever, weight loss, and intestinal hemorrhage.

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Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 K51.0
  • Cause of death: ICD-10 K51.0

2 out of 7 registries used, show all original rules.

1247

4. Check minimum number of events

None

1247

5. Include endpoints

None

1247

6. Filter based on genotype QC (FinnGen only)

1247

Control definitions (FinnGen only)

Control exclude
K11_ENERCOLNONINF

Extra metadata

First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K51
Name in latin
Enterocolitis ulcerosa [chronica]

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7478 3539 3905
Only index persons 6872 3325 3547
Unadjusted period prevalence (%)
Whole population 0.11 0.10 0.11
Only index persons 0.13 0.12 0.14
Median age at first event (years)
Whole population 43.87 41.69 45.68
Only index persons 42.10 40.37 43.72

-FinnGen-

Key figures

All Female Male
Number of individuals 1247 672 575
Unadjusted period prevalence (%) 0.24 0.23 0.25
Median age at first event (years) 41.94 36.48 48.32

-FinRegistry-

Age distribution of first events

01020304050607080900.0k0.1k0.2k0.3k0.4k0.5k0.6k0.7k0.8k0.9k1.0k1.1k1.2k1.3kAgeIndividuals

-FinnGen-

Age distribution of first events

01020304050607080020406080100120140160180200220240260AgeIndividuals

-FinRegistry-

Year distribution of first events

197019751980198519902000200520102015202020220.0k0.2k0.4k0.6k0.8k1.0k1.2k1.4k1.6k1.8kYearIndividuals

-FinnGen-

Year distribution of first events

197019751980198519901995200020052010201520202023050100150200250300YearIndividuals

-FinRegistry-

Cumulative Incidence Function

01020304050607080901000.00.10.20.30.40.50.60.70.80.91.0AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

01020304050607080901000.00.10.20.30.40.50.60.70.80.91.0AgeProbability of first incidence (%)

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1128
Matched controls
11280
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K51.5
ICD-10 Finland
Left sided colitis
+∞
323.0
716
*
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
+∞
323.0
341
*
K51.8
ICD-10 Finland
Other ulcerative colitis
+∞
323.0
395
*
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
+∞
323.0
1127
*
UJF32
NOMESCO Finland
Coloscopy
25.8
323.0
883
1384
A07EC02
ATC
mesalazine; oral, rectal
1780.5
323.0
978
41
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
9776.5
323.0
776
*
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
6337.6
323.0
422
*
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
+∞
323.0
1017
*
A07EA02
ATC
hydrocortisone; rectal
625.7
323.0
493
14
A07EA06
ATC
budesonide; oral, local oral
421.6
323.0
439
17
L04AX01
ATC
azathioprine; systemic
139.0
323.0
595
90
UJF30
NOMESCO Finland
Ileoscopy through colon
21.9
311.7
489
380
H02AB06
ATC
prednisolone; systemic
10.8
259.3
928
3397
K51.2
ICD-10 Finland
Ulcerative (chronic) proctitis
1000.9
252.3
238
*
H02AB07
ATC
prednisone; oral
12.2
237.3
494
679
K50.9
ICD-10 Finland
Crohn disease, unspecified
2417.7
225.8
211
*
K50.1
ICD-10 Finland
Crohn disease of large intestine
+∞
220.2
204
*
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
16.5
219.2
377
332
K51
ICD-10 Finland
Ulcerative colitis
+∞
210.1
195
*
K50.8
ICD-10 Finland
Other Crohn disease
2490.4
205.7
193
*
UJF14
NOMESCO Finland
Enteroscopy of ileoanal anastomosis
+∞
194.5
181
*
A07EC01
ATC
sulfasalazine; oral, rectal
12.9
191.3
370
411
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
6.5
173.7
604
1688
K50.0
ICD-10 Finland
Crohn disease of small intestine
608.4
163.4
158
*
J01MA02
ATC
ciprofloxacin; systemic
5.3
148.2
701
2661
P01AB01
ATC
metronidazole; oral, rectal
4.9
133.9
711
2929
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
+∞
128.6
121
*
L01BB02
ATC
mercaptopurine; oral
242.4
127.7
129
6
A07EA01
ATC
prednisolone; rectal
1352.5
126.6
121
*
UJF12
NOMESCO Finland
Enteroscopy through intestinal stoma
612.3
114.1
111
*
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
40.1
111.5
141
40
JFH30
NOMESCO Finland
Total colectomy, mucosal proctectomy and ileoanal anastomosis without ileostomy
1130.8
107.2
103
*
5562A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) proctitis
+∞
102.7
97
*
ZX120
NOMESCO Finland
Intravenous
7.8
100.6
253
402
D94
ICPC
Chronic enteritis/ulcerative colitis
357.0
97.6
97
*
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
90.9
97.0
107
13
56310
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Ulcerative colitis
+∞
95.2
90
*
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
82.3
94.1
105
14
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.0
88.2
462
1664
M07.5*K51.9
ICD-10 Finland
Arthropathy in ulcerative colitis
+∞
79.1
75
*
A07EC03
ATC
olsalazine; oral
+∞
74.8
71
*
5561A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) ileocolitis
+∞
73.8
70
*
5568X
ICD-9 Finland
Idiopathic proctocolitis, Other ulcerative colitis
+∞
72.7
69
*
JFG00
NOMESCO Finland
Closure of loop enterostomy without resection
104.7
71.9
78
8
K83.0
ICD-10 Finland
Cholangitis
31.3
71.2
95
33
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
14.7
70.9
122
92
TPH04
NOMESCO Finland
Cathetrisation of vein
3.9
70.6
360
1222
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
4.0
64.6
309
981
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
8.5
62.8
144
190
A05AA02
ATC
ursodeoxycholic acid; oral
19.9
60.4
92
50
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.9
59.8
552
2810
A07DA03
ATC
loperamide; oral
10.1
58.8
121
132
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
7.2
57.3
147
230
A02BC02
ATC
pantoprazole; systemic
2.8
56.3
795
5174
JN3BD
NOMESCO Finland
Extensive abdominal CT
4.6
54.0
208
529
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
5.0
53.3
188
436
WX002
NOMESCO Finland
Sedation and analgesia
3.3
48.9
297
1109
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
19.7
47.2
72
39
1370
FHL
Colonoscopy, whole colon
76.0
45.4
51
7
K50
ICD-10 Finland
Crohn disease [regional enteritis]
+∞
45.1
43
*
L04AB04
ATC
adalimumab; parenteral
11.9
44.7
84
76
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
60.5
44.7
52
9
4AA12
NOMESCO Finland
NA
454.9
44.5
44
*
JFH33
NOMESCO Finland
Total colectomy, mucosal proctectomy, ileoanal anastomosis and ileostomy
+∞
43.0
41
*
JFH10
NOMESCO Finland
Total colectomy and ileostomy
+∞
41.9
40
*
UJF92
NOMESCO Finland
Capsular endoscopy
12.9
41.7
75
62
Z93.2
ICD-10 Finland
Ileostomy status
93.7
41.1
45
5
WX302
NOMESCO Finland
Thoracal epidural anesthesy
5.8
40.8
121
227
JFF10
NOMESCO Finland
Loop enterostomy
38.5
38.1
48
13
H02AB09
ATC
hydrocortisone; systemic
10.6
37.5
74
74
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.4
37.5
208
712
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
16.1
37.4
61
40
A06AC01
ATC
ispaghula (psylla seeds); oral
2.7
37.3
312
1402
L04AA01
ATC
[U] ciclosporin; systemic
18.1
36.6
57
33
J01MA12
ATC
levofloxacin; systemic
2.9
36.1
263
1082
L04AD01
ATC
ciclosporin; systemic
11.8
35.9
67
60
JGB50
NOMESCO Finland
Mucosal proctectomy and ileoanal anastomosis
+∞
35.6
34
*
C10AC01
ATC
colestyramine; oral
10.9
35.5
69
67
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.3
35.1
461
2613
H02AB04
ATC
methylprednisolone; systemic
3.0
33.9
227
882
R50.9
ICD-10 Finland
Fever, unspecified
3.1
33.7
213
793
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
9.7
33.5
69
75
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.5
33.2
126
309
M07.5
ICD-10 Finland
Arthropathy in ulcerative colitis
+∞
32.4
31
*
JF1DG
NOMESCO Finland
Small bowel very extensive MRI with with high intensity magnet
+∞
32.4
31
*
4AB02
NOMESCO Finland
NA
72.0
31.0
35
5
N02AX02
ATC
tramadol; systemic, rectal
2.1
30.8
493
3007
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
21.2
30.6
45
22
K56.7
ICD-10 Finland
Ileus, unspecified
13.9
30.2
52
39
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
9.2
29.2
62
71
JAH00
NOMESCO Finland
Laparotomy
7.8
28.7
67
90
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
13.5
27.6
48
37
K60.3
ICD-10 Finland
Anal fistula
9.7
26.9
55
59
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
12.1
26.9
49
42
3AC01
NOMESCO Finland
NA
17.4
26.8
42
25
B01AB05
ATC
enoxaparin; parenteral
2.2
26.3
336
1825
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
21.8
26.2
38
18
JFH11
NOMESCO Finland
Laparoscopic colectomy
+∞
26.1
25
*
TJF80
NOMESCO Finland
Ostomy education
18.0
25.9
40
23
A02BC01
ATC
omeprazole; systemic
2.2
25.5
320
1720
JFG20
NOMESCO Finland
Closure of enterostomy with resection of exteriorised loop
36.5
25.3
32
9
JF1BD
NOMESCO Finland
Very extensive small bowel CT
39.8
25.0
31
8
JN3AD
NOMESCO Finland
Abdominal CT examination
3.6
24.8
118
353
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
7.9
24.8
57
75
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
24.3
328
1815
JFG40
NOMESCO Finland
Revision of enterostomy or colostomy without laparotomy
38.5
24.0
30
8
JHA00
NOMESCO Finland
Anal or perianal incision
10.9
24.0
46
44
E86
ICD-10 Finland
Volume depletion
9.1
23.2
49
56
M07.4*K50.9
ICD-10 Finland
Arthropathy in Crohn's disease [regional enteritis]
+∞
23.0
22
*
5560A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) enterocolitis
+∞
23.0
22
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
6.9
23.0
58
88
1490
FHL
Sigmoideoscopy (fiberscope)
66.4
22.9
26
*
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
4.6
22.7
82
191
K51.4
ICD-10 Finland
Inflammatory polyps
234.5
22.7
23
*
6419
FHL
Other measure in this category
234.5
22.7
23
*
JFH20
NOMESCO Finland
Proctocolectomy and ileostomy
234.5
22.7
23
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
4.4
22.5
85
207
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.8
22.2
155
607
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.1
22.2
127
437
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
4.9
22.1
74
159
M09.2*K51.9
ICD-10 Finland
Juvenile arthritis in ulcerative colitis
+∞
21.9
21
*
Z98.0
ICD-10 Finland
Intestinal bypass and anastomosis status
25.6
21.8
30
12
UJK02
NOMESCO Finland
ERCP
7.9
21.8
50
66
L04AC05
ATC
ustekinumab; parenteral
51.0
21.2
25
5
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.8
21.0
148
582
UJF34
NOMESCO Finland
Left colonoscopy
22.0
20.9
30
14
JFF13
NOMESCO Finland
Terminal enterostomy
38.0
20.8
26
7
M05BA04
ATC
alendronic acid; oral
3.8
20.8
92
259
Z94.4
ICD-10 Finland
Liver transplant status
30.7
20.6
27
9
A07AA09
ATC
vancomycin; oral
10.9
20.5
39
37
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
20.0
255
1359
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.2
20.0
247
1299
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
6.9
19.5
49
74
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
9.0
19.5
41
47
UJG02
NOMESCO Finland
Proctoscopy
6.5
18.8
49
78
C05AA08
ATC
fluocortolone; rectal, topical
2.4
18.7
181
846
K61.0
ICD-10 Finland
Anal abscess
7.0
18.6
46
68
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.2
18.4
103
346
UJK12
NOMESCO Finland
Peroral cholangioscopy
53.4
18.0
21
*
A02BC05
ATC
esomeprazole; systemic
1.8
17.9
439
2961
JH1CG
NOMESCO Finland
Extensive MRI of perianal area
27.2
17.9
24
9
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
7.2
17.8
43
62
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
2.6
17.7
135
555
K56.0
ICD-10 Finland
Paralytic ileus
13.5
17.0
29
22
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.1
16.9
96
327
4AA33
NOMESCO Finland
NA
+∞
16.7
16
*
JJC00
NOMESCO Finland
Allogenic transplantation of liver
35.6
16.7
21
6
B03BA03
ATC
hydroxocobalamin; parenteral
3.7
16.6
74
210
JFB00
NOMESCO Finland
Partial resection of small intestine
7.4
16.6
39
54
N02BE01
ATC
paracetamol; systemic, rectal
1.9
16.6
926
7966
D64.9
ICD-10 Finland
Anaemia, unspecified
2.8
16.6
113
435
JFG73
NOMESCO Finland
Excision of ileal pelvic pouch
172.4
16.5
17
*
N03AX16
ATC
pregabalin; oral
2.0
16.5
254
1448
JHD00
NOMESCO Finland
Anal dilatation
12.4
16.4
29
24
UJD02
NOMESCO Finland
Gastroscopy
3.6
16.4
75
218
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
3.8
16.4
70
192
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
4.3
16.2
61
149
K92.1
ICD-10 Finland
Melaena
3.8
16.2
70
194
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.6
16.0
123
507
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
60.9
15.8
18
*
JFA58
NOMESCO Finland
Endoscopic dilatation of colon
60.9
15.8
18
*
5586X
ICD-9 Finland
Other non-infective gastro-enteritis and colitis[KROONINEN INFLAMMATOORINEN SUOLISTOSAIRAUS, NUD]
+∞
15.7
15
*
3042
Kela drug reimbursment
NA
+∞
15.7
15
*
UJF02
NOMESCO Finland
Peroral enteroscopy
19.5
15.6
23
12
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
15.3
228
1280
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.7
15.2
502
3650
JAD30
NOMESCO Finland
Repair of incisional hernia using prosthetic material
7.9
15.2
34
44
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.3
14.9
77
247
JAP00
NOMESCO Finland
Freeing of adhesions in the peritoneal cavity
9.3
14.7
30
33
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
5.2
14.7
45
89
253
Kela drug reimbursment
NA
+∞
14.6
14
*
5551A
ICD-9 Finland
Regional enteritis, Large intestine
+∞
14.6
14
*
127
Kela drug reimbursment
Transplant complication
6.8
14.6
36
54
JHW96
NOMESCO Finland
Other operation on anus or perianal tissue
17.8
13.9
21
12
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.5
13.8
112
475
K62.8
ICD-10 Finland
Other specified diseases of anus and rectum
10.6
13.8
26
25
JFA38
NOMESCO Finland
Endoscopic dilatation of small intestine
+∞
13.6
13
*
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
34.5
13.5
17
5
SPAT1255
SPAT
Intravenous administration of medicine
2.9
13.5
84
306
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.9
13.4
83
301
A02BC03
ATC
lansoprazole; oral
1.8
13.4
294
1879
K91.4
ICD-10 Finland
Colostomy and enterostomy malfunction
26.1
13.4
18
7
JF1AD
NOMESCO Finland
Small bowel CT
21.4
13.4
19
9
WX402
NOMESCO Finland
General anaesthesia
2.0
13.3
190
1046
L04AB06
ATC
golimumab; parenteral
9.2
13.3
27
30
L04AA06
ATC
mycophenolic acid; systemic
6.2
13.2
35
58
A07AA02
ATC
nystatin; oral
3.0
13.1
77
270
D11
ICPC
Diarrhoea
2.3
13.1
133
631
SPAT1262
SPAT
Handing over of treatment supplies
2.0
13.1
194
1084
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
3.4
12.8
61
184
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
9.8
12.8
25
26
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.6
12.7
96
390
JJ5AT
NOMESCO Finland
NA
70.7
12.6
14
*
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
4.1
12.6
48
120
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.1
12.6
143
715
56399
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Other
+∞
12.5
12
*
5604
FHL
Vascular preparation or cannulation in the operating room
+∞
12.5
12
*
J01DB01
ATC
cefalexin; oral
1.7
12.5
894
7794
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
7.7
12.4
28
37
0093A
ICD-9 Finland
Ill-defined intestinal infections, Diarrhoea of presumed infectious origin
8.1
12.4
27
34
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.4
12.2
103
448
WVA20
NOMESCO Finland
Medicine administration
4.9
12.2
39
82
JHD20
NOMESCO Finland
Incision of fistula-in-ano
8.3
12.1
26
32
1380
FHL
Colonoscopy, left side
47.2
11.9
14
*
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
3.3
11.6
58
182
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.3
11.6
114
532
K59.1
ICD-10 Finland
Functional diarrhoea
3.1
11.6
62
205
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.5
11.6
53
156
56902
ICD-8 Finland
Other diseases of intestines and peritoneum, Proctitis haemorrhagica (ulcerosa)
+∞
11.5
11
*
JFG50
NOMESCO Finland
Laparotomy with revision of enterostomy or colostomy
121.2
11.4
12
*
5761C
ICD-9 Finland
Other disorders of biliary tract, Cholangitis[CHOLANGITIS SCLEROSIVA]
121.2
11.4
12
*
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
11.3
160
872
D06BX01
ATC
metronidazole; topical
2.2
11.3
119
574
Z43.2
ICD-10 Finland
Attention to ileostomy
35.4
11.3
14
*
RD210
NOMESCO Finland
NA
5.0
11.2
35
72
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
20.3
11.1
16
8
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
20.3
11.1
16
8
K74.3
ICD-10 Finland
Primary biliary cirrhosis
20.3
11.1
16
8
N02AJ06
ATC
codeine and paracetamol; systemic
1.6
11.1
390
2817
XJW99
NOMESCO Finland
Other investigative procedure on digestive system
15.7
10.8
17
11
QBE15
NOMESCO Finland
Excision of other superficial lesion of skin of trunk
15.7
10.8
17
11
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
9.0
10.8
22
25
JKE02
NOMESCO Finland
Transduodenal endoscopic incision of common bile duct orifice
6.2
10.8
28
46
JFH00
NOMESCO Finland
Total colectomy and ileorectal anastomosis
28.3
10.7
14
5
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.6
10.6
341
2401
R51.80
ICD-10 Finland
Headache
1.9
10.6
169
962
WW500
NOMESCO Finland
Blood transfusion
3.4
10.6
51
157
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.6
10.5
75
298
N02AA05
ATC
oxycodone; systemic
2.0
10.5
133
695
6525
FHL
Enterostomy occlusion
111.0
10.4
11
*
L04AA33
ATC
vedolizumab; parenteral
+∞
10.4
10
*
56300
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Regional enteritis
+∞
10.4
10
*
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
3.5
10.2
47
140
A01AB04
ATC
amphotericin B; local oral
3.2
10.1
51
162
K83.1
ICD-10 Finland
Obstruction of bile duct
8.0
10.1
22
28
T81.8
ICD-10 Finland
Other complications of procedures, not elsewhere classified
4.6
10.1
34
76
J02AC01
ATC
fluconazole; systemic
1.5
10.1
417
3112
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
3.6
10.0
44
126
N05CF01
ATC
zopiclone; oral
1.6
9.9
301
2080
R11
ICD-10 Finland
Nausea and vomiting
2.4
9.9
83
361
E0000UV
ATC
NA
1.5
9.8
400
2971
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
9.6
9.8
19
20
107
Kela drug reimbursment
Pernicious anaemia
5.4
9.7
28
53
C05AA01
ATC
hydrocortisone; rectal, topical
2.8
9.7
61
225
R4110
NOMESCO Finland
Physiotherapy
1.6
9.5
261
1757
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
2.1
9.4
106
525
JKD20
NOMESCO Finland
Anastomosis of bile duct to jejunum
100.8
9.4
10
*
JN1CM
NOMESCO Finland
Upper part of abdomen extensive MRI examination with 3 Tesla magnet
30.3
9.4
12
*
R19.8
ICD-10 Finland
Other specified symptoms and signs involving the digestive system and abdomen
6.3
9.4
24
39
JFA76
NOMESCO Finland
Closure of fistula of small intestine
+∞
9.4
9
*
6410
FHL
Panprococolectomy and ileostomy
+∞
9.4
9
*
K52.0
ICD-10 Finland
Gastroenteritis and colitis due to radiation
+∞
9.4
9
*
A02BA02
ATC
ranitidine; systemic
1.8
9.4
184
1122
3005
Kela drug reimbursment
Tofacitinib
21.9
9.4
13
6
J01DA01
ATC
[U] cefalexin; systemic
1.5
9.3
647
5369
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.0
9.3
124
663
1300
FHL
Esophagogastroduodenoscopy (also includes staining)
9.6
9.3
18
19
K85
ICD-10 Finland
Acute pancreatitis
4.9
9.2
29
61
ZXC86
NOMESCO Finland
Use of endoscopic device
13.8
9.2
15
11
R03AC02
ATC
salbutamol; inhalant
1.5
9.1
544
4368
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.9
9.1
53
187
JF2AB
NOMESCO Finland
Colongraphy with X-ray
15.7
9.0
14
9
B81
ICPC
Anaemia vit B12/folate deficiency
3.5
9.0
40
116
D18
ICPC
Change in faeces/bowel movements
4.4
9.0
31
72
JHD30
NOMESCO Finland
Incomplete incision of fistula-in-ano
18.8
8.9
13
7
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.1
8.9
107
548
K83.9
ICD-10 Finland
Disease of biliary tract, unspecified
24.2
8.9
12
5
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.7
8.8
176
1079
TQW40
NOMESCO Finland
Remowal of suture of skin
2.4
8.8
75
328
R10.0
ICD-10 Finland
Acute abdomen
3.5
8.6
38
110
A03CA02
ATC
clidinium and psycholeptics; oral
2.7
8.6
58
223
J45.9
ICD-10 Finland
Asthma, unspecified
1.7
8.6
172
1054
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.3
8.5
76
339
K52.80
ICD-10 Finland
(Hemorrhagic) colitis caused by antibiotics
90.7
8.4
9
*
JWW96
NOMESCO Finland
Other reoperation in gastroenterological surgery
90.7
8.4
9
*
6408
FHL
Colectomy and ileostomy
+∞
8.3
8
*
R01AD08
ATC
fluticasone; nasal
1.5
8.3
306
2206
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
2.7
8.3
56
215
N06AA09
ATC
amitriptyline; systemic
2.0
8.2
98
502
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
14.6
8.2
13
9
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.9
8.1
124
694
R15
ICD-10 Finland
Faecal incontinence
4.2
8.1
29
70
B01AB10
ATC
tinzaparin; parenteral
2.4
8.1
68
296
K83.8
ICD-10 Finland
Other specified diseases of biliary tract
33.6
8.1
10
*
UKC02
NOMESCO Finland
Cystoscopy
1.8
8.1
138
804
JHD33
NOMESCO Finland
Completing incision of fistula-in-ano
11.8
8.1
14
12
WX110
NOMESCO Finland
Local anesthesy
1.4
8.0
728
6279
JKA20
NOMESCO Finland
Cholecystectomy
3.8
8.0
32
86
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.3
7.9
72
325
JAD10
NOMESCO Finland
Repair of incisional hernia
7.8
7.9
17
22
K61.1
ICD-10 Finland
Rectal abscess
13.1
7.9
13
10
J05AB01
ATC
aciclovir; systemic
1.6
7.8
203
1337
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
2.7
7.8
50
188
R06AE07
ATC
cetirizine; oral
1.4
7.7
439
3452
M13.9
ICD-10 Finland
Arthritis, unspecified
2.2
7.7
76
357
UJH02
NOMESCO Finland
Anoscopy
2.8
7.7
46
167
J01FA06
ATC
roxithromycin; oral
1.5
7.7
401
3102
J01FA10
ATC
azithromycin; systemic
1.4
7.6
605
5062
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.9
7.6
109
598
ZX100
NOMESCO Finland
Oral
5.2
7.6
22
43
K65.0
ICD-10 Finland
Acute peritonitis
6.2
7.6
19
31
D70.82
ICD-10 Finland
Drug-induced neutropenia
5.8
7.5
20
35
WZC30
NOMESCO Finland
Teaching
1.8
7.5
123
706
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
7.5
474
3798
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.1
7.4
39
130
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.8
7.4
131
773
K43.0
ICD-10 Finland
Incisional hernia with obstruction, without gangrene
6.5
7.4
18
28
D95
ICPC
Anal fissure/perianal abscess
6.5
7.4
18
28
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
7.4
401
3119
K76.9
ICD-10 Finland
Liver disease, unspecified
4.8
7.3
23
49
5550A
ICD-9 Finland
Regional enteritis, Small intestine
+∞
7.3
7
*
JGB40
NOMESCO Finland
Excision of rectum and end ileostomy
+∞
7.3
7
*
5552A
ICD-9 Finland
Regional enteritis, Small intestine with large intestine
+∞
7.3
7
*
5563A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) proctosigmoiditis
+∞
7.3
7
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.7
7.3
48
185
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
2.6
7.2
50
196
TDM10
NOMESCO Finland
Puncture of maxillary antrum
2.6
7.2
50
198
JH1CM
NOMESCO Finland
Perianal extensive MRI with 3 Tesla magnet
30.2
7.2
9
*
5781B
ICD-9 Finland
Gastro-intestinal haemorrhage, Melaena[HAEMORRHAGIA EX ANO]
30.2
7.2
9
*
JX1LA
NOMESCO Finland
Kinetic X-ray of alimentary tract with pictures
30.2
7.2
9
*
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
30.2
7.2
9
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.5
7.1
54
225
J01MA01
ATC
ofloxacin; systemic
2.0
7.1
85
434
1310
FHL
Esophagogastroscopy
12.1
7.1
12
10
JFA70
NOMESCO Finland
Suture of small intestine
12.1
7.1
12
10
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.6
7.1
49
193
R4190
NOMESCO Finland
Nutritional therapy
3.1
7.0
37
124
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.7
7.0
162
1038
D99
ICPC
Disease digestive system other
5.2
7.0
20
39
J05AB11
ATC
valaciclovir; oral
1.8
6.9
123
725
A03FA01
ATC
metoclopramide; systemic, rectal
1.6
6.9
187
1246
1470
FHL
Rectoscopy
7.6
6.9
15
20
K60.4
ICD-10 Finland
Rectal fistula
13.9
6.9
11
8
XF600
NOMESCO Finland
Bloodpressure measurement
2.2
6.9
66
309
B01AA03
ATC
warfarin; systemic
1.7
6.9
150
941
M81.9
ICD-10 Finland
Osteoporosis, unspecified
3.5
6.8
30
88
C03CA01
ATC
furosemide; systemic
1.6
6.8
196
1324
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
2.4
6.8
54
229
Z98.8
ICD-10 Finland
Other specified postsurgical states
5.1
6.8
20
40
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.5
6.8
295
2185
ZX198
NOMESCO Finland
Other local administration
6.1
6.8
17
28
RS221
NOMESCO Finland
NA
4.3
6.7
23
54
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.8
6.7
111
641
L04AA29
ATC
tofacitinib; oral
22.7
6.7
9
*
B25.9
ICD-10 Finland
Cytomegaloviral disease, unspecified
22.7
6.7
9
*
K80.0
ICD-10 Finland
Calculus of gallbladder with acute cholecystitis
2.7
6.7
44
170
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.6
6.6
166
1082
M81.4
ICD-10 Finland
Drug-induced osteoporosis
12.3
6.6
11
9
H26.3
ICD-10 Finland
Drug-induced cataract
8.8
6.6
13
15
6455
FHL
Perianal fistula surgery
10.1
6.5
12
12
B07.9
ICD-10 Finland
Verruca simplex
2.9
6.5
38
136
J45.1
ICD-10 Finland
Nonallergic asthma
2.2
6.5
65
310
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
3.1
6.5
33
109
L01BB01
ATC
NA
70.2
6.4
7
*
JL5AM
NOMESCO Finland
Bile and pancreas ducts simple MRI examination with 3 Tesla magnet
70.2
6.4
7
*
JFG96
NOMESCO Finland
Other operation on intestinal stoma or pouch
70.2
6.4
7
*
JF1CM
NOMESCO Finland
Small bowel extensive MRI with with high intensity magnet
70.2
6.4
7
*
JN2DG
NOMESCO Finland
Very extensive MRI examination of lower part of abdoment with high intensity magnet
7.4
6.4
14
19
NA6BG
NOMESCO Finland
Sacro-iliac joint MRI examination with high intensity magnet
3.6
6.4
27
77
JN2CG
NOMESCO Finland
Extensive MRI examination of lower part of abdoment with high intensity magnet
4.1
6.4
23
57
A41.9
ICD-10 Finland
Sepsis, unspecified
2.8
6.4
38
138
JKE32
NOMESCO Finland
Endoscopic dilatation of bile duct
14.4
6.4
10
7
KBV02
NOMESCO Finland
Cystoscopic insertion of stent into ureter
3.9
6.4
24
62
K29.3
ICD-10 Finland
Chronic superficial gastritis
3.0
6.4
34
116
M45
ICD-10 Finland
Ankylosing spondylitis
3.1
6.3
32
105
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.5
6.3
264
1939
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.6
6.3
180
1217
JFG53
NOMESCO Finland
Revision of ileal pelvic pouch
+∞
6.3
6
*
E87.6
ICD-10 Finland
Hypokalaemia
3.2
6.3
30
95
R03AC03
ATC
terbutaline; inhalant
1.7
6.2
138
870
N82.3
ICD-10 Finland
Fistula of vagina to large intestine
26.8
6.2
8
*
J01CA04
ATC
amoxicillin; systemic
1.4
6.2
846
7654
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.7
6.2
128
791
L52
ICD-10 Finland
Erythema nodosum
7.7
6.1
13
17
R06.0
ICD-10 Finland
Dyspnoea
1.5
6.1
209
1469
K85.9
ICD-10 Finland
Acute pancreatitis, unspecified
3.6
6.1
25
70
N05BA04
ATC
oxazepam; oral
1.5
6.1
227
1627
K59.9
ICD-10 Finland
Functional intestinal disorder, unspecified
4.9
6.1
18
37
Z71.8
ICD-10 Finland
Other specified counselling
1.5
6.1
231
1665
J01FF01
ATC
clindamycin; systemic
1.5
6.1
253
1858
Z01.2
ICD-10 Finland
Dental examination
1.4
6.0
400
3200
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
3.7
6.0
24
66

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
864
1009
25.62
307.65
7.4
1.3
236.67
91.30
ug/g
15.18
814
767
751
865
20.31
307.65
2.3
1.2
—
—
—
0
0
947
3659
7.60
240.84
11.7
4.5
36.23
36.07
g/l
0.44
919
3419
805
3120
5.46
189.51
12.7
5.4
—
—
—
0
0
863
3811
5.11
164.82
4.3
2.1
75.39
75.16
nmol/l
0.09
830
3456
903
4392
4.83
144.85
15.0
5.5
0.72
0.67
%
2.66
876
4101
952
4829
5.11
144.04
15.0
5.4
0.04
0.04
e9/l
2.00
900
4214
948
4808
5.05
143.06
15.0
5.4
0.57
0.57
e9/l
0.10
897
4190
600
2198
4.33
142.03
4.1
2.0
3.09
2.91
mg/l
0.92
540
1882
918
4566
4.83
141.62
15.1
5.7
8.72
8.51
%
1.52
890
4286
967
5009
5.14
141.06
15.2
5.8
0.18
0.19
e9/l
0.59
911
4424
914
4540
4.79
141.02
14.9
5.5
2.71
2.84
%
1.04
885
4231
957
4968
4.98
137.81
15.0
5.5
1.82
2.01
e9/l
2.22
915
4409
924
4717
4.70
134.92
15.0
5.5
27.44
28.55
%
2.71
899
4407
916
4653
4.65
134.51
14.1
5.3
58.55
56.84
%
5.15
891
4364
994
5568
4.87
122.43
17.9
8.6
4.06
4.07
e9/l
0.07
940
4879
1129
7292
6.79
107.91
20.7
6.8
78.55
76.67
u/l
0.64
1113
6869
267
697
4.60
95.21
5.3
4.2
0.48
0.60
%
0.39
61
165
389
1348
3.74
93.51
3.1
2.4
12.03
14.11
umol/l
6.16
374
1251
280
771
4.39
93.03
5.7
4.5
0.99
0.95
%
0.07
76
222
272
734
4.46
92.78
5.7
4.6
0.04
0.13
%
1.88
73
202
351
1140
3.89
92.77
3.0
2.4
20.06
24.32
%
6.11
320
987
131
181
7.97
91.30
6.2
2.9
3.99
4.31
e9/l
0.80
131
181
133
188
7.80
90.88
6.4
3.2
57.74
56.38
%
0.46
133
188
363
1232
3.75
89.59
3.0
2.4
2.46
2.36
g/l
2.37
345
1144
258
692
4.44
88.43
5.7
4.6
0.13
0.13
%
0.01
62
176
150
265
6.30
82.95
1.9
1.2
55.00
123.46
titre
2.28
12
26
265
800
3.94
76.58
4.2
2.3
0.24
0.22
g/l
3.35
250
747
1049
7129
3.97
75.40
8.0
3.7
12.72
10.51
mm/h
5.96
997
6645
638
3316
2.89
73.54
6.6
3.2
31.26
31.74
u/l
0.17
590
3167
211
559
4.34
72.72
2.3
1.7
1.21
1.33
g/l
0.56
194
514
243
728
3.90
70.62
3.0
2.7
11.49
10.47
g/l
3.70
219
663
777
4799
2.64
59.02
10.6
6.1
10.54
11.38
umol/l
1.73
758
4547
94
146
6.88
58.57
2.5
1.6
0.92
0.90
g/l
0.04
79
108
720
4298
2.60
58.56
18.9
8.7
0.00
0.00
e9/l
0.01
648
3539
67
71
9.92
57.30
1.5
1.1
257.50
105.71
titre
—
24
7
188
541
3.91
57.25
1.6
1.2
—
—
—
0
0
737
4516
2.55
55.66
4.9
2.7
97.74
116.41
ug/l
1.43
691
4219
465
2299
2.63
55.43
10.7
4.2
—
—
—
0
0
326
1355
2.90
54.41
1.8
1.3
465.12
527.68
titre
0.36
86
271
315
1319
2.86
51.56
1.5
1.6
—
—
—
0
0
600
3479
2.40
49.21
9.8
8.0
1.14
1.19
inr
0.82
192
1072
455
2333
2.50
49.08
6.1
4.2
—
—
—
0
0
640
3859
2.35
47.44
8.1
5.8
1.22
1.21
mmol/l
1.05
600
3513
637
3841
2.35
47.11
2.8
2.0
—
—
—
0
0
81
138
6.21
46.02
4.1
2.5
4.97
34.39
u/ml
0.50
81
127
688
4321
2.32
45.78
9.3
6.5
1.21
1.21
mmol/l
0.01
582
3655
514
2890
2.32
43.99
4.5
2.5
63.24
56.72
u/l
1.41
498
2698
132
369
3.88
41.45
2.1
1.4
4.06
9.00
u/ml
—
22
6
223
867
2.91
41.11
4.2
2.4
38.53
93.74
u/l
0.50
206
742
438
2359
2.32
40.85
11.4
6.4
—
—
—
0
0
311
1442
2.54
40.48
2.2
1.7
1113.44
1182.42
nmol/l
0.64
226
1117
578
3508
2.21
40.11
2.3
1.9
96.03
95.20
pmol/l
0.16
378
1874
437
2373
2.30
39.77
8.6
3.7
95.59
92.21
%
2.09
424
2315
112
291
4.13
38.87
6.2
3.4
51.82
1443.58
u/ml
1.44
100
250
366
1882
2.34
37.51
1.6
1.7
—
—
—
0
0
247
1061
2.66
37.36
6.0
2.7
6.38
8.29
umol/l
1.21
228
917
52
71
7.60
36.24
2.0
1.5
—
—
—
0
0
38
38
10.28
33.72
3.7
3.1
—
—
—
0
0
434
2524
2.10
31.86
5.6
4.0
7.40
7.40
ph
0.22
104
493
340
1830
2.18
30.26
2.3
1.6
427.40
51097196.12
pmol/l
2.89
311
1550
190
808
2.59
28.85
5.3
4.3
4.05
27.61
ug/l
1.54
143
663
27
0
+∞
28.23
1.8
0.0
3.23
—
mg/l
—
27
0
279
1428
2.23
27.88
6.5
3.4
0.78
0.82
mmol/l
7.17
262
1349
262
1320
2.25
27.14
2.5
2.0
—
—
—
0
0
200
903
2.45
26.64
3.3
2.7
2.01
1.80
%
1.29
181
813
59
124
4.94
26.64
3.3
3.5
0.77
1.26
%
0.98
45
108
88
256
3.62
25.90
3.3
3.4
—
—
—
0
0
172
734
2.56
25.80
9.7
8.2
9.89
9.17
mmol/l
0.64
163
701
232
1133
2.29
25.79
7.5
5.9
1.03
1.03
mmol/l
0.07
225
1054
1164
10162
3.19
24.97
31.7
12.0
17.07
22.67
mg/l
11.26
1049
7849
244
1232
2.22
24.96
1.4
1.2
—
—
—
0
0
198
919
2.37
24.70
2.4
2.0
314.29
371.73
nmol/l
4.42
181
851
315
1771
2.04
24.28
3.1
2.6
530.42
559.88
mosm/kgh2o
1.36
285
1520
740
5508
1.84
23.83
7.2
4.5
6.77
6.63
mmol/l
0.77
704
5109
464
3008
1.86
23.26
3.6
2.2
—
—
—
0
0
186
866
2.35
22.95
1.4
1.5
—
—
—
0
0
337
1975
1.97
22.91
1.6
1.5
21.01
20.63
nmol/l
0.17
302
1710
336
1984
1.95
22.26
2.1
1.4
2.61
2.37
g/l
1.64
257
1273
853
6715
1.86
22.05
5.4
3.8
—
—
—
0
0
163
737
2.39
21.43
7.6
3.5
0.97
1.86
mmol/l
1.56
135
595
372
2300
1.88
21.28
3.4
2.2
—
—
—
0
0
147
648
2.44
20.41
3.7
2.8
77.55
72.98
e9/l
0.54
117
495
73
220
3.46
20.35
1.2
1.2
—
—
—
0
0
418
2737
1.79
19.54
3.9
2.9
22.20
95.52
e6/l
2.11
355
2088
313
1878
1.89
19.39
3.2
2.4
6.31
5.95
e6/l
0.19
286
1640
371
2349
1.82
19.36
1.8
1.9
—
—
—
0
0
174
846
2.23
19.22
4.2
4.0
—
—
—
0
0
36
65
5.67
19.22
1.1
1.1
—
—
—
0
0
169
819
2.23
18.80
4.8
3.5
—
—
—
0
0
56
149
3.89
18.74
5.4
4.1
59.25
285.87
u/ml
0.76
49
141
150
693
2.32
18.69
13.2
8.6
—
—
—
0
0
65
193
3.50
18.54
1.2
1.3
343.24
242.69
u/ml
0.72
34
125
377
2444
1.78
17.95
3.8
2.8
—
—
—
0
0
616
4586
1.68
17.59
5.8
3.8
—
—
—
0
0
381
2493
1.76
17.48
3.9
2.8
0.58
0.42
e6/l
0.37
314
1858
30
50
6.12
17.36
34.2
28.1
6.69
7.30
ug/l
0.68
25
44
33
62
5.44
16.90
1.1
1.0
—
—
—
0
0
18
17
10.73
16.46
2.7
1.8
—
—
—
0
0
35
72
4.97
16.21
3.1
3.5
59.26
51.48
%
1.22
23
56
39
88
4.54
16.20
1.4
1.3
2.95
2.88
g/l
0.08
28
61
39
88
4.54
16.20
1.4
1.3
7.73
6.64
g/l
0.75
28
60
39
88
4.54
16.20
1.4
1.3
0.35
0.33
g/l
0.13
27
58
66
216
3.17
16.14
1.3
1.6
—
—
—
0
0
39
90
4.44
15.76
1.4
1.4
—
—
—
0
0
73
262
2.90
15.22
1.6
1.1
—
—
—
0
0
87
346
2.63
14.93
1.6
2.1
1.34
1.45
g/l
0.59
79
302
37
86
4.40
14.82
3.9
4.1
—
—
—
0
0
35
78
4.59
14.77
1.9
2.3
0.93
1.17
e9/l
0.41
13
45
60
200
3.10
14.25
1.2
1.6
97.99
125.56
u/ml
—
8
43
456
3269
1.62
14.22
4.5
3.4
71.93
73.47
e6/l
0.02
371
2256
53
173
3.16
13.05
1.0
1.1
—
—
—
0
0
125
623
2.12
12.83
4.8
4.0
105.65
83.76
ng/l
1.04
114
558
179
1014
1.89
12.81
23.8
20.1
1.29
1.28
inr
0.04
38
148
143
768
1.97
11.96
1.5
1.4
—
—
—
0
0
191
1131
1.81
11.83
2.2
1.7
—
—
—
0
0
227
1417
1.74
11.73
3.1
2.7
2.34
2.44
e6/l
0.06
129
763
27
59
4.66
11.68
1.8
2.3
517.19
492.69
e6/l
0.09
21
51
201
1215
1.78
11.61
1.3
1.3
—
—
—
0
0
1169
10840
2.25
11.30
25.5
9.1
26.93
27.30
u/l
0.34
1161
10519
128
679
1.99
11.08
3.3
2.8
4.05
4.15
e9/l
0.23
99
557
78
344
2.35
10.77
1.3
1.2
—
—
—
0
0
600
4788
1.49
10.59
4.1
3.2
0.00
0.01
estimate
0.80
178
861
349
2502
1.55
10.20
3.7
3.6
—
—
—
0
0
41
134
3.13
10.12
1.1
1.2
—
—
—
0
0
214
1370
1.68
9.98
2.8
2.1
30.74
29.38
s
2.52
207
1327
229
1495
1.65
9.90
3.0
2.5
0.80
0.97
e6/l
0.59
131
833
312
2196
1.56
9.85
2.1
1.7
1.46
0.99
mg/l
1.03
246
1633
589
4736
1.46
9.70
5.5
4.4
0.00
0.00
estimate
0.50
177
909
79
369
2.22
9.56
2.6
2.1
21.05
21.06
s
0.01
74
327
31
88
3.59
9.54
3.0
1.5
0.83
1.00
g/l
2.68
31
88
342
2477
1.52
9.43
3.3
2.7
—
—
—
0
0
587
4736
1.45
9.39
4.0
3.2
0.00
0.00
estimate
0.00
175
885
746
6302
1.46
9.32
5.4
3.8
17.50
1812.95
e6/l
1.31
12
87
67
296
2.34
9.24
1.8
1.6
0.22
0.24
g/l
0.72
61
283
1110
10225
1.78
9.24
27.0
13.5
3.91
3.96
mmol/l
5.98
1091
9952
1107
10192
1.77
9.20
26.9
13.4
139.26
139.65
mmol/l
5.73
1087
9939
68
307
2.29
8.93
1.8
1.6
1.18
1.19
g/l
0.05
63
294
442
3405
1.46
8.89
3.7
3.2
42.43
41.43
ng/l
0.02
288
2128
60
258
2.39
8.81
1.5
1.4
240.85
314.33
ug/g
2.17
39
148
828
7178
1.46
8.72
5.7
3.0
61.35
45.73
u/l
4.49
795
6808
46
178
2.64
8.41
1.0
1.1
—
—
—
0
0
26
72
3.67
8.31
1.7
2.0
925.35
721.25
e6/l
0.58
17
28
29
87
3.39
8.24
1.1
1.0
292.48
286.27
mg/l
0.13
29
78
121
699
1.81
8.07
5.3
3.7
1.22
1.23
mmol/l
0.32
115
607
26
74
3.57
8.00
2.0
2.0
41.83
41.33
%
—
6
12
151
935
1.70
7.91
10.0
8.0
-0.04
1.02
mmol/l
1.77
114
739
42
161
2.66
7.84
2.0
2.2
16.10
4.90
umol/l
1.83
29
117
150
941
1.68
7.48
10.1
7.9
4.94
5.13
kpa
1.47
141
900
150
942
1.67
7.45
9.9
7.9
12.99
12.50
kpa
0.54
142
903
46
194
2.42
7.09
4.2
4.3
1.96
2.35
mmol/l
0.57
31
125
101
576
1.82
7.03
3.9
3.4
5.05
5.17
kpa
0.84
94
539
355
2725
1.42
6.94
4.1
2.9
—
—
—
0
0
176
1171
1.59
6.92
1.8
1.4
—
—
—
0
0
78
414
1.94
6.78
3.9
3.6
—
—
—
0
0
21
58
3.67
6.76
2.2
2.2
6.17
15.07
%
—
6
27
351
2700
1.42
6.75
2.3
2.1
184.87
225.65
u/l
0.43
336
2554
26
83
3.18
6.74
3.9
4.0
—
—
—
0
0
16
36
4.49
6.72
2.2
4.4
—
—
—
0
0
126
778
1.69
6.67
11.0
8.8
116.57
122.82
g/l
2.51
121
750
72
375
1.98
6.61
4.3
2.3
0.72
0.66
%
0.84
72
367
329
2510
1.42
6.61
4.4
3.5
0.00
0.01
estimate
1.28
172
877
35
134
2.66
6.59
2.1
1.3
39.50
66.25
mmol/l
4.74
22
114
91
513
1.83
6.59
2.0
2.5
—
—
—
0
0
74
393
1.94
6.43
1.4
1.2
—
1.19
—
0
27
379
2979
1.39
6.37
3.5
3.3
2.33
2.35
mmol/l
1.30
335
2663
329
2526
1.41
6.34
3.6
3.3
39.61
324.52
mg/l
3.13
255
1635
44
192
2.34
6.32
3.3
3.5
—
—
—
0
0
131
831
1.64
6.26
11.2
8.5
96.77
95.75
%
1.86
125
803
365
2862
1.39
6.20
3.5
3.2
8.48
8.11
mmol/l
0.74
323
2429
1138
10750
1.67
6.15
24.2
11.4
—
—
—
0
0
77
421
1.88
6.15
1.1
1.1
—
—
—
0
0
97
570
1.76
6.13
3.9
3.4
7.41
7.41
ph
—
8
73
87
497
1.81
6.05
1.1
1.1
—
201.22
titre
—
0
9
950
8661
1.41
6.05
34.0
14.7
13.97
13.57
%
9.16
944
8492
55
273
2.06
5.80
1.8
2.2
9.65
11.06
mg/l
0.63
47
253
338
2665
1.37
5.44
4.5
4.0
8.21
9.73
mg/mmol
0.23
255
1718
57
297
1.96
5.28
1.3
1.2
—
—
—
0
0
21
69
3.08
5.23
1.1
1.1
—
104.64
—
0
5
14
35
4.03
5.17
1.0
1.4
—
—
—
0
0
13
31
4.23
5.10
1.9
2.0
—
—
—
0
0
223
1668
1.41
4.88
3.3
3.3
677.98
435.73
ng/l
0.25
157
1176
293
2301
1.36
4.77
1.4
1.2
0.84
1.64
u/ml
1.84
75
644
30
129
2.36
4.53
1.1
1.3
—
—
—
0
0
8
8
10.05
4.52
1.0
1.0
—
—
—
0
0
27
111
2.46
4.48
3.0
2.1
31.78
32.79
pg
0.47
27
111
27
112
2.44
4.41
1.2
1.2
—
—
—
0
0
44
227
1.97
4.25
2.2
4.0
34.26
31.10
mg/l
0.28
37
185
37
182
2.06
4.07
3.7
2.5
—
—
—
0
0
24
98
2.48
4.06
2.6
2.8
—
—
—
0
0
13
37
3.54
4.05
1.0
1.0
—
—
—
0
0
67
401
1.71
4.05
3.9
3.3
—
—
—
0
0
43
224
1.95
4.05
2.0
2.4
36.79
38.06
g/l
0.57
43
193
44
232
1.93
4.01
1.3
1.3
—
—
—
0
0
225
1743
1.35
3.95
1.3
1.3
27.36
27.82
iu/ml
0.02
61
543
47
256
1.87
3.89
1.3
1.2
6.11
2.79
u/ml
—
8
29
10
24
4.19
3.89
1.0
1.3
—
—
—
0
0
306
2486
1.31
3.86
3.4
2.5
4418.43
5041.45
umol/l
0.09
272
2223
72
446
1.65
3.84
16.5
10.0
—
—
—
0
0
278
2238
1.31
3.74
3.3
3.0
1190.92
1146.57
ng/l
0.07
235
1859
30
141
2.16
3.73
2.2
2.5
—
—
—
0
0
47
260
1.84
3.72
1.3
1.2
14.23
9.92
u/ml
0.22
11
41
41
217
1.92
3.71
6.2
3.7
33.83
34.62
umol/l
0.11
35
187
17
61
2.81
3.69
4.4
4.2
—
—
—
0
0
33
162
2.07
3.68
1.5
1.7
—
—
—
0
0
12
35
3.45
3.62
1.0
1.1
—
—
—
0
0
42
227
1.88
3.58
2.3
4.0
46.00
77.60
mg/l
0.57
35
186
60
364
1.68
3.49
1.3
1.2
—
—
—
0
0
12
36
3.36
3.48
1.2
1.1
—
—
—
0
0
41
225
1.85
3.36
2.2
3.9
1.20
1.75
ratio
—
5
28
12
37
3.27
3.34
1.8
2.8
—
—
—
0
0
76
498
1.56
3.27
2.5
2.2
7998.79
3615.08
u/l
0.39
21
203
11
33
3.35
3.19
1.0
1.1
—
—
—
0
0
34
180
1.91
3.12
2.8
2.4
16.43
16.46
%
0.02
15
98
5
5
10.03
2.98
1.6
1.2
—
—
—
0
0
52
819
0.62
2.94
1.3
1.4
—
—
—
0
0
13
46
2.85
2.92
2.5
2.5
921.62
1134.50
u/ml
0.15
13
46
37
634
0.57
2.92
1.2
1.2
—
—
—
0
0
86
595
1.48
2.90
3.4
2.6
—
—
—
0
0
22
102
2.18
2.88
3.6
2.6
—
—
—
0
0
32
171
1.89
2.88
2.0
4.3
—
—
—
0
0
63
409
1.57
2.85
2.5
1.7
—
—
—
0
0
207
1660
1.30
2.84
1.3
1.3
2.02
11.73
u/ml
6.04
75
695
829
7713
1.22
2.84
3.9
3.9
14.68
14.57
pmol/l
0.60
758
7114
22
103
2.16
2.81
3.6
2.7
106.50
105.26
mmol/l
0.58
22
103
22
103
2.16
2.81
3.6
2.7
3.95
4.05
mmol/l
0.35
22
103
10
31
3.24
2.77
1.7
1.6
—
—
—
0
0
12
42
2.88
2.75
1.9
2.6
—
—
—
0
0
39
226
1.75
2.73
3.2
2.7
23.17
25.01
mmol/l
1.69
32
201
8
19
4.23
2.68
2.6
2.0
—
—
—
0
0
21
99
2.14
2.65
1.3
1.3
—
—
nmol/l
—
0
0
7
15
4.69
2.60
1.1
1.1
—
—
—
0
0
38
223
1.73
2.56
1.5
1.4
64.34
179.05
pmol/l
0.93
38
218
14
56
2.52
2.53
1.1
1.2
—
—
—
0
0
8
21
3.83
2.46
2.5
2.4
—
—
—
0
0
1180
11514
1.46
2.40
42.6
17.6
91.40
90.57
fl
7.23
1174
11382
1180
11515
1.46
2.39
42.5
17.6
30.28
30.25
pg
0.20
1174
11381
33
190
1.76
2.39
3.4
1.9
—
—
—
0
0
1180
11516
1.46
2.38
42.8
17.7
4.44
4.56
e12/l
14.40
1171
11240
60
403
1.51
2.38
1.3
1.3
209.00
210.54
miu/ml
0.01
33
196
1179
11505
1.45
2.37
42.9
17.7
273.38
252.45
e9/l
17.03
1172
11251
7
17
4.13
2.36
2.1
1.4
—
—
—
0
0
85
613
1.41
2.35
2.6
2.9
174.85
169.76
ng/l
0.03
75
551
1180
11519
1.45
2.34
42.9
17.7
6.87
6.70
e9/l
1.93
1171
11238
1180
11521
1.45
2.32
43.1
17.7
133.20
137.21
g/l
17.58
1175
11385
31
178
1.76
2.28
1.3
1.2
2.82
6.36
u/ml
1.10
17
74
17
79
2.17
2.25
1.3
1.2
—
—
—
0
0
250
2113
1.23
2.20
3.7
3.2
—
—
—
0
0
34
203
1.69
2.19
2.8
4.3
—
—
—
0
0
12
48
2.51
2.19
1.3
1.3
140.77
150.56
nmol/l
0.22
12
48
54
362
1.51
2.18
1.2
1.3
6.91
8.52
u/l
0.72
41
294
15
68
2.22
2.11
1.3
1.1
—
—
—
0
0
46
300
1.55
2.11
2.5
2.3
647.34
305.97
ug/l
0.36
41
280
26
146
1.80
2.07
1.3
1.4
—
—
—
0
0
20
103
1.96
2.06
1.7
1.5
—
28.00
—
0
6
29
170
1.72
2.01
1.1
1.2
—
—
—
0
0
91
686
1.35
1.97
2.5
2.3
3.91
7.81
ug/l
3.40
84
620
21
112
1.89
1.97
1.4
1.3
0.63
0.54
nmol/l
0.49
21
105
35
219
1.62
1.92
1.1
1.1
—
—
—
0
0
35
219
1.62
1.92
1.1
1.1
—
—
—
0
0
102
788
1.32
1.88
1.2
1.2
—
—
—
0
0
7
22
3.19
1.88
1.0
1.7
—
—
—
0
0
15
72
2.10
1.86
1.1
1.1
1.05
1.04
ratio
—
8
31
19
101
1.89
1.81
1.4
1.2
—
—
—
0
0
69
506
1.38
1.79
7.2
7.2
23.47
24.52
mmol/l
1.31
63
467
8
29
2.77
1.79
1.0
1.0
—
—
—
0
0
963
9236
1.19
1.79
4.8
4.5
1.66
1.96
mu/l
1.59
901
8570
11
48
2.30
1.70
1.1
1.0
238.55
214.38
iu/ml
0.07
11
48
181
1523
1.22
1.67
3.8
2.9
2.45
2.43
mmol/l
1.13
160
1352
1003
9671
1.19
1.67
28.3
12.7
38.90
40.47
%
6.33
776
7521
22
127
1.75
1.64
1.1
1.3
—
57.10
—
0
7
26
158
1.66
1.63
3.1
3.0
—
—
—
0
0
19
327
0.57
1.63
1.6
1.4
—
—
—
0
0
46
320
1.45
1.62
6.7
4.6
—
—
—
0
0
5
14
3.58
1.61
1.0
2.2
—
—
—
0
0
16
84
1.92
1.60
1.7
1.4
—
65.11
—
0
9
368
4070
0.86
1.58
3.0
2.6
—
—
—
0
0
38
257
1.49
1.54
1.2
1.1
—
—
—
0
0
8
33
2.43
1.54
1.9
1.8
72.63
53.56
ug/l
—
8
33
19
108
1.77
1.51
1.6
1.5
—
—
—
0
0
71
542
1.33
1.47
5.0
5.0
—
—
—
0
0
19
317
0.59
1.47
1.6
1.4
—
—
—
0
0
10
45
2.23
1.46
1.1
1.7
—
—
—
0
0
9
38
2.38
1.45
1.3
1.2
—
—
—
0
0
9
38
2.38
1.45
3.0
1.3
—
—
—
0
0
15
80
1.89
1.45
1.0
1.1
—
—
—
0
0
19
315
0.60
1.44
1.6
1.4
—
—
—
0
0
972
10034
0.86
1.44
4.5
4.0
1.49
1.44
mmol/l
2.39
907
9396
17
95
1.80
1.43
1.3
1.3
—
—
—
0
0
20
119
1.69
1.38
2.2
2.3
—
—
—
0
0
27
174
1.56
1.38
1.1
1.2
—
—
—
0
0
9
41
2.20
1.37
1.0
1.8
—
—
—
0
0
6
23
2.62
1.37
1.3
1.1
—
—
—
0
0
44
315
1.41
1.36
1.9
2.4
—
—
—
0
0
24
151
1.60
1.35
1.1
1.3
41.37
36.98
u/l
0.08
19
127
33
224
1.49
1.34
1.7
2.2
0.96
0.86
nmol/l
0.19
26
192
6
24
2.51
1.30
1.3
1.1
—
—
—
0
0
6
24
2.51
1.30
1.3
1.1
—
—
—
0
0
6
24
2.51
1.30
1.3
1.1
—
—
—
0
0
9
43
2.10
1.30
2.0
2.2
—
—
—
0
0
18
106
1.71
1.30
1.4
1.5
285.15
282.43
mosm/kgh2o
0.10
13
81
13
70
1.87
1.24
1.8
1.1
—
—
—
0
0
14
240
0.58
1.23
1.9
1.6
—
—
—
0
0
5
19
2.64
1.21
1.4
1.4
—
—
—
0
0
14
78
1.80
1.21
1.1
1.2
—
—
—
0
0
25
164
1.54
1.21
3.0
2.4
—
—
—
0
0
26
173
1.51
1.18
1.3
1.4
—
—
—
0
0
14
79
1.78
1.17
1.5
2.5
—
—
—
0
0
158
1817
0.85
1.12
2.9
2.8
0.72
0.74
ug/l
0.13
98
1088
37
270
1.38
1.07
5.7
6.3
1.57
1.26
mmol/l
0.50
32
233
76
615
1.25
1.07
1.4
1.3
21.08
25.01
iu/l
0.53
62
523
104
873
1.21
1.05
2.5
2.3
13.02
13.05
nmol/l
0.01
94
781
12
67
1.80
1.05
1.0
1.0
1.34
1.34
u/ml
—
6
23
12
67
1.80
1.05
2.4
1.9
9.88
11.24
%
0.44
12
67
18
114
1.59
1.03
1.1
1.1
—
—
—
0
0
24
163
1.48
1.02
1.6
1.5
—
—
—
0
0
115
1344
0.84
1.01
1.3
1.3
—
—
—
0
0
998
10219
0.88
0.99
4.8
4.4
2.66
2.82
mmol/l
7.55
925
9553
13
76
1.72
0.99
1.5
2.3
1.50
2.11
u/field
—
8
35
9
49
1.84
0.98
1.2
1.3
—
—
—
0
0
0
31
0.00
0.96
0.0
1.3
—
—
—
0
0
985
10087
0.89
0.95
4.6
4.0
4.62
4.71
mmol/l
2.06
924
9488
943
9680
0.89
0.94
4.2
3.6
1.38
1.30
mmol/l
2.09
876
9030
701
6723
1.10
0.90
3.6
3.4
—
—
—
0
0
108
1253
0.85
0.88
1.6
1.8
—
—
—
0
0
8
43
1.87
0.87
1.0
1.1
1059.13
1780.86
miu/ml
—
8
43
6
30
2.00
0.87
1.3
1.3
—
—
—
0
0
30
401
0.74
0.86
2.4
2.2
—
—
—
0
0
24
170
1.42
0.85
1.1
1.1
1.00
135.24
iu/ml
—
6
41
12
72
1.67
0.85
1.0
1.1
—
—
—
0
0
6
31
1.94
0.84
1.5
2.4
—
—
—
0
0
58
471
1.24
0.83
1.8
2.6
21.26
46.45
u/ml
2.05
58
453
83
700
1.20
0.83
3.6
3.1
—
—
—
0
0
11
177
0.62
0.81
1.2
1.2
—
—
—
0
0
26
189
1.38
0.81
2.4
2.2
132.22
131.24
g/l
0.07
18
144
14
90
1.56
0.78
1.0
1.2
48974.89
196550.32
e6/l
—
9
65
6
34
1.77
0.76
1.0
1.0
—
—
—
0
0
9
53
1.70
0.75
1.4
3.0
1985.00
2073.19
ml
—
9
47
12
75
1.61
0.75
1.2
1.3
2509.86
1958.70
e6/l
—
7
47
142
1264
1.14
0.74
1.4
1.4
—
—
—
0
0
5
24
2.09
0.74
1.8
2.4
—
—
—
0
0
6
106
0.56
0.72
1.3
2.2
—
—
—
0
0
20
142
1.42
0.72
2.3
1.9
—
1337.14
—
0
7
10
61
1.64
0.68
1.2
1.2
—
—
—
0
0
7
42
1.67
0.68
1.4
1.9
—
—
—
0
0
17
119
1.43
0.67
3.2
2.9
0.85
0.86
nmol/l
0.05
12
89
7
43
1.63
0.67
1.0
1.2
—
—
—
0
0
11
70
1.58
0.65
1.2
1.3
3091.67
27921.97
e6/l
—
6
39
12
80
1.50
0.60
1.2
1.1
—
—
—
0
0
8
52
1.54
0.59
1.3
1.3
—
—
—
0
0
19
142
1.34
0.54
1.5
1.6
—
—
—
0
0
45
377
1.20
0.54
2.4
3.0
—
—
—
0
0
9
63
1.43
0.52
2.0
1.9
—
—
—
0
0
952
9684
0.93
0.52
4.6
4.0
5.84
5.85
mmol/l
0.05
876
8947
6
41
1.47
0.50
1.5
1.5
—
—
—
0
0
10
67
1.50
0.49
1.0
1.0
0.31
0.38
u/ml
—
5
17
7
45
1.56
0.49
2.4
1.5
—
—
—
0
0
25
200
1.26
0.46
1.3
1.4
0.32
0.34
nmol/l
0.09
18
162
11
77
1.43
0.45
1.2
1.3
—
—
—
0
0
38
322
1.19
0.43
2.7
3.5
0.25
0.26
g/l
0.05
22
140
5
32
1.56
0.42
1.8
3.4
—
—
—
0
0
294
3084
0.94
0.41
4.7
4.4
2.25
2.34
ug/l
0.10
267
2773
29
240
1.21
0.41
1.8
2.6
—
—
—
0
0
43
370
1.17
0.41
1.6
1.7
—
—
—
0
0
0
17
0.00
0.40
0.0
1.5
—
—
—
0
0
0
17
0.00
0.40
0.0
1.4
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
8
60
1.34
0.40
1.0
1.3
—
—
—
0
0
8
61
1.31
0.39
1.3
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
2.4
—
—
—
0
0
57
504
1.14
0.39
1.8
1.5
294.06
299.26
mu/l
0.06
51
455
9
67
1.35
0.38
1.2
1.3
—
—
—
0
0
9
67
1.35
0.38
1.3
2.8
—
43.80
—
0
21
12
89
1.35
0.38
2.7
2.8
—
—
—
0
0
125
1347
0.92
0.37
1.8
1.6
—
—
—
0
0
22
179
1.23
0.37
1.0
1.1
4.46
2.53
u/ml
—
5
86
22
179
1.23
0.37
2.2
1.7
—
—
—
0
0
10
72
1.39
0.37
13.8
11.8
0.63
0.63
mmol/l
—
10
64
34
291
1.17
0.36
1.7
1.3
—
—
—
0
0
5
77
0.65
0.35
1.0
1.2
—
—
—
0
0
28
236
1.19
0.35
2.3
2.4
61.30
103.67
ug/min
0.48
15
152
73
662
1.11
0.34
3.9
3.5
4.46
4.56
pmol/l
0.44
65
591
25
209
1.20
0.34
5.8
3.7
19.65
28.71
mg/l
1.55
17
136
6
46
1.31
0.33
1.2
1.1
—
—
—
0
0
14
110
1.28
0.31
4.3
2.7
—
—
—
0
0
12
93
1.29
0.30
1.3
1.4
0.94
1.30
promille
—
7
75
78
717
1.09
0.30
2.3
2.4
37.44
20.73
au/ml
—
5
55
266
2567
1.05
0.25
1.7
1.6
1.45
1.40
mmol/l
0.43
224
2201
5
38
1.32
0.23
1.0
2.5
—
—
—
0
0
83
778
1.07
0.22
1.3
1.2
116.99
151.11
iu/ml
0.40
33
317
5
42
1.19
0.21
1.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
0.21
—
0
5
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
3.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
0.36
—
0
5
0
10
0.00
0.21
0.0
10.5
—
—
—
0
0
12
98
1.23
0.21
1.0
1.6
—
—
—
0
0
26
230
1.13
0.20
1.2
1.1
0.37
2.34
u/ml
1.66
11
94
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
6
50
1.20
0.19
3.7
2.5
45.17
50.34
umol/l
—
6
41
112
1066
1.06
0.19
1.5
1.4
—
—
—
0
0
10
81
1.24
0.18
1.2
1.1
—
—
—
0
0
7
61
1.15
0.17
1.1
1.4
9.69
5.90
ug/l
—
7
52
310
3028
1.03
0.17
1.6
1.5
—
—
—
0
0
15
173
0.87
0.16
1.3
1.2
—
—
—
0
0
18
158
1.14
0.16
1.4
1.6
—
—
—
0
0
8
71
1.13
0.16
1.1
1.2
—
—
—
0
0
23
207
1.11
0.15
1.1
1.1
6.36
5.30
u/ml
0.08
12
102
22
198
1.11
0.14
1.1
1.1
0.61
1.55
u/ml
0.55
11
78
22
199
1.11
0.13
1.1
1.4
21.31
21.26
u/l
0.00
17
164
62
652
0.95
0.13
1.5
1.4
—
—
—
0
0
48
509
0.94
0.13
1.1
1.1
—
—
—
0
0
17
190
0.89
0.13
1.2
1.1
—
9.59
—
0
17
13
147
0.88
0.11
1.6
1.4
—
—
—
0
0
10
86
1.16
0.11
1.0
1.1
—
—
—
0
0
211
2067
1.03
0.10
4.0
3.4
1.02
1.02
kg/l
0.10
25
288
22
202
1.09
0.10
1.0
1.6
—
—
—
0
0
24
222
1.08
0.10
2.0
1.6
13115.41
11392.67
e6/l
0.14
17
169
5
44
1.14
0.10
2.0
2.3
1.46
1.93
ug/l
—
5
37
67
696
0.96
0.09
1.6
1.7
—
—
—
0
0
18
165
1.09
0.08
1.1
1.1
1.38
3.47
u/ml
—
6
64
24
225
1.07
0.07
1.4
1.2
—
—
—
0
0
8
76
1.05
0.07
1.0
1.6
—
—
—
0
0
12
108
1.11
0.07
2.4
1.6
—
—
—
0
0
12
108
1.11
0.07
2.4
1.6
—
—
—
0
0
12
108
1.11
0.07
2.4
1.6
—
—
—
0
0
12
108
1.11
0.07
2.4
1.6
—
—
—
0
0
7
84
0.83
0.07
2.6
3.0
49.97
28.36
mg/l
—
7
63
8
90
0.89
0.06
1.1
1.2
34.20
40.48
mg/l
—
8
69
11
99
1.11
0.06
1.2
1.7
—
—
—
0
0
45
434
1.04
0.06
1.6
2.0
—
—
—
0
0
53
547
0.97
0.06
1.9
1.9
—
—
—
0
0
905
9078
0.99
0.05
6.1
5.1
39.42
39.07
mmol/mol
0.47
848
8532
64
653
0.98
0.03
1.4
1.3
23.46
42.31
au/ml
—
5
30
16
151
1.06
0.03
1.1
1.0
0.82
0.53
u/ml
—
5
37
10
92
1.09
0.03
1.2
1.2
—
—
—
0
0
32
311
1.03
0.02
14.8
9.3
—
—
—
0
0
54
550
0.98
0.02
1.9
2.1
—
—
—
0
0
28
278
1.01
0.00
3.0
2.0
4.82
5.00
iu/l
—
9
106
18
181
0.99
0.00
1.1
1.1
4.18
3.43
u/ml
—
5
64
51
511
1.00
0.00
1.8
2.1
—
—
—
0
0
10
103
0.97
0.00
3.7
4.9
—
77.84
—
0
34
22
223
0.99
0.00
1.0
1.5
14.88
23.59
e6/l
0.18
17
177
22
223
0.99
0.00
1.0
1.6
20.41
933.15
e6/l
0.95
17
183
56
557
1.01
0.00
1.9
2.1
—
—
—
0
0
55
555
0.99
0.00
1.8
2.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
1.14
—
0
5
0
5
0.00
0.00
0.0
1.6
—
2.72
—
0
5
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
60
1.00
0.00
5.3
7.6
—
—
—
0
0
0
8
0.00
0.00
0.0
4.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
7
77
0.91
0.00
2.0
2.3
—
0.97
—
0
6
0
7
0.00
0.00
0.0
5.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
6
65
0.92
0.00
1.8
1.2
26.25
31.23
nmol/l
—
6
52
5
50
1.00
0.00
1.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
187.33
—
0
6
0
7
0.00
0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
7
73
0.96
0.00
1.0
1.1
—
0.33
—
0
12
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint ULCERENTER and mortality.

Females

Parameter HR [95% CI] p-value
ULCERENTER 1.635 [1.44, 1.86] < 0.001
Birth year 0.996 [0.99, 1.0] 0.321

During the follow-up period (1.1.1998 — 31.12.2019), 499 out of 3272 females with ULCERENTER died.

Males

Parameter HR [95% CI] p-value
ULCERENTER 1.552 [1.39, 1.74] < 0.001
Birth year 0.987 [0.98, 1.0] 0.017

During the follow-up period (1.1.1998 — 31.12.2019), 724 out of 3513 males with ULCERENTER died.

Mortality risk

Mortality risk for people of age

years, who have ULCERENTER.

N-year risk Females Males
1 0.182% 0.27%
5 0.994% 1.839%
10 2.632% 4.43%
15 5.101% 8.5%
20 8.421% 14.2%

Relationships between endpoints

Index endpoint: ULCERENTER – Ulcerative enterocolitis

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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