Ulcerative proctitis

ULCERPROCT

proctitis: An inflammatory process affecting the anus. It is usually caused by sexually transmitted infectious agents and/or inflammatory bowel disease.

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Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 K51.2
  • Cause of death: ICD-10 K51.2

2 out of 7 registries used, show all original rules.

2641

4. Check minimum number of events

None

2641

5. Include endpoints

None

2641

6. Filter based on genotype QC (FinnGen only)

2550

Control definitions (FinnGen only)

Control exclude
K11_ENERCOLNONINF

Extra metadata

First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K51
Name in latin
Proctitis ulcerosa [chronica]

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 13877 7303 6509
Only index persons 13418 7120 6298
Unadjusted period prevalence (%)
Whole population 0.20 0.21 0.18
Only index persons 0.25 0.26 0.24
Median age at first event (years)
Whole population 42.59 40.72 44.56
Only index persons 42.09 40.47 43.93

-FinnGen-

Key figures

All Female Male
Number of individuals 2550 1458 1092
Unadjusted period prevalence (%) 0.51 0.52 0.50
Median age at first event (years) 44.34 40.39 49.60

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
2641
Matched controls
26410
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K62.8
ICD-10 Finland
Other specified diseases of anus and rectum
46.5
315.3
186
43
D94
ICPC
Chronic enteritis/ulcerative colitis
265.4
307.7
263
11
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
27.3
307.7
268
109
L01BB02
ATC
mercaptopurine; oral
166.7
307.7
335
23
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
16384.0
307.7
1069
*
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
3028.8
307.7
1178
7
A07EA06
ATC
budesonide; oral, local oral
288.3
307.7
1164
72
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
+∞
307.7
342
*
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
53.7
307.7
185
37
A07EC02
ATC
mesalazine; oral, rectal
3380.3
307.7
2439
94
UJF32
NOMESCO Finland
Coloscopy
19.5
307.7
1921
3174
L04AX01
ATC
azathioprine; systemic
46.4
307.7
779
236
UJF30
NOMESCO Finland
Ileoscopy through colon
15.8
307.7
1023
1014
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
+∞
307.7
2188
*
K51.8
ICD-10 Finland
Other ulcerative colitis
2765.2
307.7
481
*
H02AB06
ATC
prednisolone; systemic
5.3
307.7
1879
8369
K51.5
ICD-10 Finland
Left sided colitis
8897.8
307.7
1098
*
K51
ICD-10 Finland
Ulcerative colitis
1084.8
307.7
451
5
K51.2
ICD-10 Finland
Ulcerative (chronic) proctitis
+∞
307.7
2641
5
A07EC01
ATC
sulfasalazine; oral, rectal
8.1
307.7
606
933
A07EA02
ATC
hydrocortisone; rectal
805.2
307.7
1240
29
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
16.2
307.7
852
755
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
+∞
298.8
281
*
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
+∞
294.4
277
*
A07EA01
ATC
prednisolone; oral, rectal
897.9
253.5
245
*
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
52.8
253.2
145
29
H02AB07
ATC
prednisone; oral
5.0
252.8
664
1661
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.4
188.3
1038
4268
K50.9
ICD-10 Finland
Crohn disease, unspecified
935.2
180.5
175
*
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
6.2
170.2
315
567
K50.8
ICD-10 Finland
Other Crohn disease
+∞
153.7
146
*
UJF14
NOMESCO Finland
Enteroscopy of ileoanal anastomosis
223.8
144.5
148
7
K50.1
ICD-10 Finland
Crohn disease of large intestine
1417.0
138.8
134
*
L04AC05
ATC
ustekinumab; parenteral
55.3
123.3
70
13
M07.5*K51.9
ICD-10 Finland
Arthropathy in ulcerative colitis
+∞
117.6
112
*
A06AC01
ATC
ispaghula (psylla seeds); oral
2.8
115.2
798
3567
A07EC03
ATC
olsalazine; oral
+∞
113.3
108
*
L04AB04
ATC
adalimumab; parenteral
7.9
110.1
155
207
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.6
108.1
859
4093
J01MA02
ATC
ciprofloxacin; systemic
2.5
107.9
1160
6365
ZX120
NOMESCO Finland
Intravenous
3.8
106.5
366
1078
L04AB02
ATC
infliximab; parenteral
121.5
97.7
105
9
D16
ICPC
Rectal bleeding
7.1
95.0
146
215
56310
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Ulcerative colitis
+∞
89.1
85
*
UJF92
NOMESCO Finland
Capsular endoscopy
9.2
88.6
109
123
K50.0
ICD-10 Finland
Crohn disease of small intestine
+∞
88.0
84
*
JFG00
NOMESCO Finland
Closure of loop enterostomy without resection
23.0
86.6
63
28
UJG02
NOMESCO Finland
Proctoscopy
7.5
84.6
124
173
C05AA08
ATC
fluocortolone; rectal, topical
2.9
84.2
459
1778
P01AB01
ATC
metronidazole; oral, rectal
2.2
82.2
1205
7311
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
76.5
654
3152
4AB02, ,
NOMESCO Finland
30.5
72.8
48
16
5561A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) ileocolitis
+∞
72.2
69
*
K92.1
ICD-10 Finland
Melaena
4.5
72.2
183
428
3042, ,
Kela drug reimbursment
+∞
67.0
64
*
253, ,
Kela drug reimbursment
+∞
67.0
64
*
5560A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) enterocolitis
+∞
63.8
61
*
JFH30
NOMESCO Finland
Total colectomy, mucosal proctectomy and ileoanal anastomosis without ileostomy
324.7
63.7
64
*
UJF12
NOMESCO Finland
Enteroscopy through intestinal stoma
218.5
62.4
64
*
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
3.8
61.0
194
536
WX002
NOMESCO Finland
Sedation and analgesia
2.3
60.9
538
2602
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
6.4
60.1
101
163
L04AG05
ATC
vedolizumab; parenteral
+∞
56.5
54
*
A07AA09
ATC
vancomycin; oral
9.3
56.1
68
75
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
5.6
55.8
108
200
L04AB06
ATC
golimumab; parenteral
10.2
55.0
62
62
L04AA33
ATC
[U] vedolizumab
+∞
52.3
50
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.1
51.6
578
3059
JFH10
NOMESCO Finland
Total colectomy and ileostomy
265.7
51.3
52
*
5568X
ICD-9 Finland
Idiopathic proctocolitis, Other ulcerative colitis
+∞
51.2
49
*
5562A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) proctitis
+∞
51.2
49
*
4AA12, ,
NOMESCO Finland
65.8
50.4
58
9
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
15.6
49.5
43
28
A02BC02
ATC
pantoprazole; systemic
1.9
49.3
1738
13369
256, ,
Kela drug reimbursment
+∞
48.1
46
*
A07DA03
ATC
loperamide; oral
4.7
47.4
112
247
UJF34
NOMESCO Finland
Left colonoscopy
14.1
46.8
43
31
JFF10
NOMESCO Finland
Loop enterostomy
14.1
46.8
43
31
C10AC01
ATC
colestyramine; oral
5.2
46.8
98
195
JFG20
NOMESCO Finland
Closure of enterostomy with resection of exteriorised loop
14.2
46.0
42
30
UJF30, ,
SPAT
8.2
44.5
59
73
JGB50
NOMESCO Finland
Mucosal proctectomy and ileoanal anastomosis
+∞
43.9
42
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
43.8
1010
6754
M07.5
ICD-10 Finland
Arthropathy in ulcerative colitis
+∞
42.8
41
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.7
41.2
135
380
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
40.7
1063
7329
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
40.3
619
3630
UJH02
NOMESCO Finland
Anoscopy
3.5
39.9
141
417
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
2.7
38.8
214
821
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.4
36.9
264
1149
L04AD01
ATC
ciclosporin; systemic
5.0
35.9
78
160
D18
ICPC
Change in faeces/bowel movements
4.3
34.9
91
217
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.1
34.4
387
2025
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
4.3
34.4
90
215
A02BC05
ATC
esomeprazole; systemic
1.7
34.2
1004
7058
A02BC03
ATC
lansoprazole; oral
1.8
34.1
676
4262
Z93.2
ICD-10 Finland
Ileostomy status
42.6
34.1
42
10
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
5.8
32.4
59
103
A06AC51
ATC
ispaghula, combinations; oral
3.0
31.9
143
489
TJF80
NOMESCO Finland
Ostomy education
7.7
31.5
44
58
JFH20
NOMESCO Finland
Proctocolectomy and ileostomy
+∞
31.3
30
*
JFH33
NOMESCO Finland
Total colectomy, mucosal proctectomy, ileoanal anastomosis and ileostomy
+∞
31.3
30
*
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.0
30.7
354
1865
JFH11
NOMESCO Finland
Laparoscopic colectomy
+∞
30.3
29
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
2.9
30.2
147
527
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.3
29.8
247
1143
K61.0
ICD-10 Finland
Anal abscess
4.5
29.5
73
167
K50
ICD-10 Finland
Crohn disease [regional enteritis]
284.4
27.8
28
*
XX6XT
NOMESCO Finland
Other intravascular therapy with radiological guidance
10.8
27.8
30
28
K83.0
ICD-10 Finland
Cholangitis
5.9
27.1
49
85
JHB30
NOMESCO Finland
Rubber band ligature of haemorrhoids or prolapse of mucosa
2.5
26.5
166
677
H02AB09
ATC
hydrocortisone; systemic
3.6
25.5
84
237
3AC01, ,
NOMESCO Finland
6.2
25.4
43
70
JN3AD
NOMESCO Finland
Abdominal CT examination
2.1
25.3
274
1407
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.7
25.1
517
3261
JHA00
NOMESCO Finland
Anal or perianal incision
4.5
24.3
60
137
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
2.8
24.3
121
439
JH1CG
NOMESCO Finland
Extensive MRI of perianal area
9.7
24.1
28
29
A02BC01
ATC
omeprazole; systemic
1.7
24.1
617
4117
N02BE01
ATC
paracetamol; systemic, rectal
1.8
24.0
2248
20152
K62.6
ICD-10 Finland
Ulcer of anus and rectum
5.5
23.4
45
83
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.9
23.4
317
1759
N02AX02
ATC
tramadol; systemic, rectal
1.5
23.1
986
7399
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.5
22.9
153
643
JFG73
NOMESCO Finland
Excision of ileal pelvic pouch
+∞
21.9
21
*
N02AJ06
ATC
codeine and paracetamol; systemic
1.5
20.9
1058
8178
D12.0
ICD-10 Finland
Benign neoplasm: Caecum
3.7
20.9
65
177
K51.4
ICD-10 Finland
Inflammatory polyps
+∞
20.9
20
*
56902
ICD-8 Finland
Other diseases of intestines and peritoneum, Proctitis haemorrhagica (ulcerosa)
+∞
20.9
20
*
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
4.4
20.8
52
120
J01DB01
ATC
cefalexin; oral
1.6
20.7
2129
19005
WVA20
NOMESCO Finland
Medicine administration
3.3
20.5
76
232
1370
FHL
Colonoscopy, whole colon
20.2
20.4
30
15
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.6
20.2
617
4270
D11
ICPC
Diarrhoea
1.8
20.2
331
1946
M09.2*K51.9
ICD-10 Finland
Juvenile arthritis in ulcerative colitis
+∞
19.8
19
*
H02AB04
ATC
methylprednisolone; systemic
1.8
19.2
329
1957
JAH00
NOMESCO Finland
Laparotomy
3.3
19.0
72
223
C05AA01
ATC
hydrocortisone; rectal, topical
2.5
18.9
122
505
4AA33, ,
NOMESCO Finland
+∞
18.8
18
*
ZXC86
NOMESCO Finland
Use of endoscopic device
7.7
18.7
26
34
D01
ICPC
Abdominal pain/cramps general
1.8
18.4
302
1773
B01AB05
ATC
enoxaparin; parenteral
1.5
18.1
660
4737
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.1
17.9
166
803
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.9
17.9
219
1172
J02AC01
ATC
fluconazole; systemic
1.5
17.8
967
7510
Z2221
NOMESCO Finland
Medical doctor
1.5
17.8
662
4770
L04AA01
ATC
[U] ciclosporin
4.6
17.7
42
93
L04AX03
ATC
methotrexate; systemic
1.9
17.7
235
1291
SPAT1263
SPAT
Sampling
1.4
17.3
994
7790
1490
FHL
Sigmoideoscopy (fiberscope)
24.2
17.3
24
10
M45
ICD-10 Finland
Ankylosing spondylitis
3.2
17.3
68
216
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
3.0
17.3
76
258
JHD00
NOMESCO Finland
Anal dilatation
6.2
17.2
29
47
A05AA02
ATC
ursodeoxycholic acid; oral
3.5
17.2
58
167
J01MA12
ATC
levofloxacin; systemic
1.7
17.1
388
2490
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
2.2
17.0
151
717
K60.3
ICD-10 Finland
Anal fistula
3.5
17.0
59
173
SAA01
NOMESCO Finland
Simple examination of mouth
1.5
16.7
1875
16538
NA6BG
NOMESCO Finland
Sacro-iliac joint MRI examination with high intensity magnet
3.4
16.7
60
180
K56.0
ICD-10 Finland
Paralytic ileus
5.8
16.6
30
52
A02BA02
ATC
ranitidine; systemic
1.6
16.5
383
2472
JFG40
NOMESCO Finland
Revision of enterostomy or colostomy without laparotomy
18.0
16.5
25
14
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
3.2
16.2
63
199
A03CA02
ATC
clidinium and psycholeptics; oral
2.4
16.0
112
481
D07AC01
ATC
betamethasone; topical
1.4
15.9
821
6285
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
15.9
1056
8459
D06BX01
ATC
metronidazole; topical
1.8
15.9
258
1508
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
4.5
15.9
38
85
Z01.2
ICD-10 Finland
Dental examination
1.4
15.8
1143
9288
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
15.8
582
4172
K59.1
ICD-10 Finland
Functional diarrhoea
2.2
15.7
128
588
K52.1
ICD-10 Finland
Toxic gastroenteritis and colitis
160.9
15.5
16
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.0
15.3
167
857
K62.7
ICD-10 Finland
Radiation proctitis
7.0
15.3
23
33
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.0
15.2
162
826
JF1DG
NOMESCO Finland
Small bowel very extensive MRI with with high intensity magnet
17.8
15.1
23
13
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
5.6
15.1
28
50
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.8
15.0
237
1373
3005
Kela drug reimbursment
Tofacitinib
11.8
15.0
27
23
D99
ICPC
Disease digestive system other
4.6
14.9
35
77
K56.7
ICD-10 Finland
Ileus, unspecified
4.3
14.8
37
86
N05CF01
ATC
zopiclone; oral
1.5
14.7
672
5016
D04
ICPC
Rectal/anal pain
3.8
14.7
44
117
R19.8
ICD-10 Finland
Other specified symptoms and signs involving the digestive system and abdomen
3.8
14.7
44
117
UKC02
NOMESCO Finland
Cystoscopy
1.7
14.7
294
1823
J05AB01
ATC
aciclovir; systemic
1.5
14.5
509
3604
J01FA10
ATC
azithromycin; systemic
1.4
14.5
1459
12465
Z43.2
ICD-10 Finland
Attention to ileostomy
36.2
14.4
18
5
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
4.0
14.4
41
105
ZXE20
NOMESCO Finland
More than three and less than five hours
1.7
14.4
281
1730
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.8
14.3
243
1438
K62.9
ICD-10 Finland
Disease of anus and rectum, unspecified
5.4
14.0
27
50
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.6
13.7
407
2775
R03AC02
ATC
salbutamol; inhalant
1.4
13.7
1332
11273
M46.1
ICD-10 Finland
Sacroiliitis, not elsewhere classified
3.4
13.6
48
143
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.8
13.6
226
1331
JGB40
NOMESCO Finland
Excision of rectum and end ileostomy
+∞
13.5
13
*
E0000UV, ,
ATC
1.4
13.5
970
7817
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
2.4
13.2
92
395
L01BA01
ATC
methotrexate; systemic
2.4
13.1
86
359
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
2.8
13.1
65
236
R50.9
ICD-10 Finland
Fever, unspecified
1.6
13.1
343
2271
I84.9
ICD-10 Finland
Unspecified hemorrhoids without complication
2.2
13.1
106
486
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.4
13.1
1371
11704
L04AA29
ATC
[U] tofacitinib
10.1
13.0
25
25
D12.8
ICD-10 Finland
Benign neoplasm: Rectum
2.4
12.9
86
362
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
12.9
999
8133
B80
ICPC
Iron deficiency anaemia
2.8
12.7
65
240
JG1JB
NOMESCO Finland
Defekography with X-ray
4.9
12.6
27
55
K52.80
ICD-10 Finland
(Hemorrhagic) colitis caused by antibiotics
130.6
12.4
13
*
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.0
12.4
144
756
JFF13
NOMESCO Finland
Terminal enterostomy
14.4
12.3
20
14
SAA02
NOMESCO Finland
Basic examination of mouth
1.4
11.9
1721
15318
K60.2
ICD-10 Finland
Anal fissure, unspecified
3.1
11.9
50
166
N03AX16
ATC
[U] pregabalin
1.5
11.9
483
3510
K91.4
ICD-10 Finland
Colostomy and enterostomy malfunction
14.7
11.8
19
13
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.3
11.8
1321
11319
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.1
11.8
116
575
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
1.7
11.7
223
1362
SPAT1131
SPAT
Colonoscopy
2.6
11.5
66
259
K52.0
ICD-10 Finland
Gastroenteritis and colitis due to radiation
+∞
11.5
11
*
K30
ICD-10 Finland
Functional dyspepsia
1.6
11.4
254
1618
SPAT1262
SPAT
Handing over of treatment supplies
1.5
11.3
345
2364
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.7
11.3
235
1471
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.5
11.2
388
2727
JF2AB
NOMESCO Finland
Colongraphy with X-ray
17.1
11.2
17
10
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.3
11.1
866
7013
R01AD09
ATC
mometasone; nasal
1.3
11.1
1121
9429
R06.0
ICD-10 Finland
Dyspnoea
1.4
11.1
531
3969
J45.9
ICD-10 Finland
Asthma, unspecified
1.5
11.1
400
2834
J31.0
ICD-10 Finland
Chronic rhinitis
1.7
11.1
204
1235
KMAK, ,
NOMESCO Finland
1.3
11.1
1308
11251
WZC00
NOMESCO Finland
Treatment plan or consultation
1.4
11.0
827
6657
Z98.0
ICD-10 Finland
Intestinal bypass and anastomosis status
11.2
11.0
20
18
N03AX12
ATC
[U] gabapentin; oral
1.5
11.0
346
2383
J05AB11
ATC
valaciclovir; oral
1.5
11.0
312
2101
SPAT1255
SPAT
Intravenous administration of medicine
1.9
10.9
138
746
D64.9
ICD-10 Finland
Anaemia, unspecified
1.8
10.9
173
1005
M54.5
ICD-10 Finland
Low back pain
1.3
10.9
844
6827
JF1BD
NOMESCO Finland
Very extensive small bowel CT
12.0
10.8
19
16
SPAT1301
SPAT
No procedures
1.4
10.8
646
5016
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.3
10.8
841
6808
K55.9
ICD-10 Finland
Vascular disorder of intestine, unspecified
17.9
10.7
16
9
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.1
10.6
96
462
D12.2
ICD-10 Finland
Benign neoplasm: Ascending colon
2.6
10.5
60
235
UJF02
NOMESCO Finland
Peroral enteroscopy
8.5
10.5
22
26
WX892
NOMESCO Finland
Monitored bed care
1.8
10.5
151
852
L04AF03
ATC
upadacitinib; oral
14.2
10.5
17
12
TPH07
NOMESCO Finland
Cathetrisation of artery
1.7
10.5
203
1247
S18
ICPC
Laceration/cut
1.3
10.4
958
7931
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.6
10.4
285
1905
R02
ICPC
Shortness of breath/dyspnoea
1.6
10.4
256
1670
J01CA04
ATC
amoxicillin; systemic
1.4
10.3
2071
19129
UJD02
NOMESCO Finland
Gastroscopy
2.1
10.3
93
446
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
3.8
10.3
31
83
A03BA03
ATC
hyoscyamine; oral
4.7
10.2
23
49
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
2.3
10.2
79
356
WZA90
NOMESCO Finland
Other medical or dental certificate
1.4
10.2
540
4103
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
1.7
10.1
183
1103
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.3
10.1
980
8169
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.3
10.0
721
5757
R01AD08
ATC
fluticasone; nasal
1.4
9.9
678
5365
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.3
9.9
1152
9832
D12.3
ICD-10 Finland
Benign neoplasm: Transverse colon
2.6
9.9
55
213
JFB00
NOMESCO Finland
Partial resection of small intestine
3.5
9.9
33
95
E86
ICD-10 Finland
Volume depletion
3.0
9.9
43
146
S29
ICPC
Skin symptom/complaint other
1.5
9.8
387
2788
K62.3
ICD-10 Finland
Rectal prolapse
3.6
9.8
31
86
R10.2
ICD-10 Finland
Pelvic and perineal pain
2.4
9.8
64
268
Z3231
NOMESCO Finland
Registered nurse
1.4
9.8
569
4389
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
2.8
9.8
49
180
I84.5
ICD-10 Finland
External hemorrhoids without complication
2.4
9.8
67
287
I84.1
ICD-10 Finland
Internal hemorrhoids with other complications
2.6
9.7
54
209
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
3.9
9.7
28
73
XJH00
NOMESCO Finland
Transanal ultrasonography
2.0
9.6
98
493
N06AX11
ATC
mirtazapine; oral
1.3
9.6
742
5977
L88
ICPC
Rheumatoid/seropositive arthritis
2.1
9.6
85
406
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
4.5
9.5
23
52
M25.5
ICD-10 Finland
Pain in joint
1.3
9.5
736
5926
K03.82
ICD-10 Finland
Split tooth for reasons other than trauma
1.4
9.5
526
4025
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
3.4
9.4
33
98
J01AA02
ATC
doxycycline; systemic
1.3
9.4
1802
16382
B01AB10
ATC
tinzaparin; parenteral
1.6
9.4
199
1251
1380
FHL
Colonoscopy, left side
+∞
9.4
9
*
5586X
ICD-9 Finland
Other non-infective gastro-enteritis and colitis[KROONINEN INFLAMMATOORINEN SUOLISTOSAIRAUS, NUD]
+∞
9.4
9
*
5589X
ICD-9 Finland
Other non-infective gastro-enteritis and colitis, Other and unspecified non-infectious gastro-enteritis and colitis
+∞
9.4
9
*
M07.4*K50.9
ICD-10 Finland
Arthropathy in Crohn's disease [regional enteritis]
+∞
9.4
9
*
M79.0
ICD-10 Finland
Rheumatism, unspecified
2.3
9.4
71
318
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.3
9.3
1315
11477
WX704
NOMESCO Finland
Intubation
1.7
9.3
171
1036
M81.9
ICD-10 Finland
Osteoporosis, unspecified
2.3
9.3
68
300
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.7
9.3
168
1014
D07AD01
ATC
clobetasol; topical
1.5
9.2
343
2442
M46.9
ICD-10 Finland
Inflammatory spondylopathy, unspecified
3.2
9.2
35
110
R51.80
ICD-10 Finland
Headache
1.4
9.2
369
2667
Z93
ICD-10 Finland
Artificial opening status
15.6
9.0
14
9
ZXD10
NOMESCO Finland
Scheduled procedure
1.3
9.0
784
6413
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.4
8.9
432
3226
M05BA04
ATC
alendronic acid; oral
1.8
8.9
119
657
JHB96
NOMESCO Finland
Other procedure for haemorrhoids or prolapse of mucosa
4.5
8.8
21
47
J01EA01
ATC
trimethoprim; systemic
1.4
8.8
502
3852
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
1.6
8.8
230
1520
K62.2
ICD-10 Finland
Anal prolapse
4.0
8.8
24
60
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.4
8.7
471
3583
SHA01
NOMESCO Finland
Stomatognathic treatment, simple
1.5
8.7
270
1854
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.1
8.7
84
415
WX402
NOMESCO Finland
General anaesthesia
1.4
8.6
463
3517
J01FA09
ATC
clarithromycin; systemic
1.3
8.6
712
5776
UJF32, ,
SPAT
2.3
8.6
62
272
R52.9
ICD-10 Finland
Pain, unspecified
1.6
8.6
203
1311
K83.8
ICD-10 Finland
Other specified diseases of biliary tract
16.3
8.5
13
8
R01AD12
ATC
fluticasone furoate; nasal
1.3
8.5
780
6414
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.4
8.5
397
2945
D07AB02
ATC
hydrocortisone butyrate; topical
1.3
8.4
644
5162
R53
ICD-10 Finland
Malaise and fatigue
1.4
8.4
516
4003
M03BX02
ATC
tizanidine; oral
1.3
8.4
1496
13367
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.3
8.4
609
4848
R31
ICD-10 Finland
Unspecified haematuria
1.6
8.3
174
1090
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.7
8.3
161
991
SPAT1254
SPAT
Administration of medicine
1.5
8.2
277
1933
-1, ,
NOMESCO Finland
1.3
8.2
804
6666
A98
ICPC
Health maint/preventive medicine
1.8
8.2
2543
24662
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.1
8.2
74
357
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
1.6
8.2
194
1255
OAB74
NOMESCO Finland
Nutritional guidance related to treatment and rehabilitation for medical condition
3.6
8.1
26
73
A01AB09
ATC
miconazole; local oral
1.7
7.9
156
963
SBB10
NOMESCO Finland
Dental impressions
1.7
7.9
157
971
K08.80
ICD-10 Finland
Toothache NOS
1.5
7.9
213
1419
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
1.5
7.9
262
1824
WX720
NOMESCO Finland
Own respiration
1.9
7.9
100
544
T81.8
ICD-10 Finland
Other complications of procedures, not elsewhere classified
2.6
7.9
43
166
SAA03
NOMESCO Finland
Extended examination of mouth
1.3
7.8
947
8054
ZXD05
NOMESCO Finland
Urgent procedure
1.3
7.8
677
5517
K02.1
ICD-10 Finland
Caries of dentine
1.3
7.8
1482
13295
M01AH01
ATC
celecoxib; oral
1.4
7.8
326
2373
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
1.9
7.7
90
476
A29
ICPC
General symptom/complaint other
1.5
7.7
233
1592
A02BC04
ATC
rabeprazole; oral
1.6
7.6
190
1243
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.5
7.6
209
1397
M13.9
ICD-10 Finland
Arthritis, unspecified
1.6
7.6
154
958
M01AH02
ATC
rofecoxib; oral
1.5
7.6
210
1406
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
2.5
7.6
44
175
R05
ICPC
Cough
1.3
7.6
506
3972
G04CA02
ATC
tamsulosin; oral
1.4
7.6
376
2817
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.3
7.5
642
5214
ZXE00
NOMESCO Finland
One hour or less
1.3
7.5
846
7124
WW200
NOMESCO Finland
Immunization
2.2
7.5
60
276
SXC05
NOMESCO Finland
Other oral or dental procedure
1.7
7.4
146
901
D12.5
ICD-10 Finland
Benign neoplasm: Sigmoid colon
2.0
7.4
76
384
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
2.3
7.4
53
232
SFA20
NOMESCO Finland
Two-surface restoration
1.3
7.4
1443
12944
SFA10
NOMESCO Finland
One-surface restoration
1.3
7.4
1333
11853
298, ,
Kela drug reimbursment
7.7
7.4
16
21
M05BX04
ATC
denosumab; parenteral
1.9
7.3
83
435
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
2.3
7.3
53
234
56399
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Other
+∞
7.3
7
*
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
1.7
7.3
121
714
A06AD11
ATC
lactulose; oral
1.5
7.3
229
1576
SPAT1249
SPAT
Treatment-related counselling outside office
1.3
7.3
867
7343
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
1.9
7.3
82
429
JHW96
NOMESCO Finland
Other operation on anus or perianal tissue
6.2
7.2
18
29
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.3
7.2
582
4689
K60.1
ICD-10 Finland
Chronic anal fissure
2.2
7.2
55
248
J01DA01
ATC
[U] cefalexin
1.2
7.2
1423
12767
WX110
NOMESCO Finland
Infiltration anesthesia
1.3
7.2
1751
16085
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
1.5
7.2
210
1423
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
1.6
7.2
166
1067
3029
Kela drug reimbursment
Upadacitinib
7.3
7.2
16
22
A07AA02
ATC
nystatin; oral
1.8
7.1
102
576
JFG50
NOMESCO Finland
Laparotomy with revision of enterostomy or colostomy
30.1
7.1
9
*
JFG96
NOMESCO Finland
Other operation on intestinal stoma or pouch
30.1
7.1
9
*
S10
ICPC
Boil/carbuncle
1.7
7.1
124
743
AA1AD
NOMESCO Finland
CT of head and brain
1.3
7.1
473
3712
R06AX27
ATC
desloratadine; oral
1.3
7.0
685
5655
EP1AE
NOMESCO Finland
Neck ultrasound examination
1.7
7.0
112
654
Z71.8
ICD-10 Finland
Other specified counselling
1.3
7.0
709
5881
D07AC13
ATC
mometasone; topical
1.3
7.0
617
5028
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.4
7.0
295
2148
J01DA09
ATC
[U] cefadroxil
1.3
7.0
583
4718
JAP00
NOMESCO Finland
Freeing of adhesions in the peritoneal cavity
3.4
7.0
24
71
SPAT1141
SPAT
Excision of skin or mucous membrane lesion
1.9
7.0
83
443
R06AE07
ATC
cetirizine; oral
1.3
6.9
1019
8831
D93
ICPC
Irritable bowel syndrome
2.8
6.9
33
119
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.4
6.9
266
1906
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
1.8
6.9
95
532
J01MA06
ATC
norfloxacin; oral
1.5
6.9
237
1663
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.5
6.8
206
1407
A03FA01
ATC
metoclopramide; systemic, rectal
1.3
6.8
431
3353
E000002, ,
ATC
1.5
6.8
238
1674
A02BA03
ATC
famotidine; systemic
2.2
6.8
57
268
K59.4
ICD-10 Finland
Anal spasm
5.7
6.7
18
32
N06AX22
ATC
agomelatine; oral
2.1
6.7
61
295
K52.2
ICD-10 Finland
Allergic and dietetic gastroenteritis and colitis
16.7
6.7
10
6
K63.3
ICD-10 Finland
Ulcer of intestine
16.7
6.7
10
6
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
1.6
6.7
139
870
WZC30
NOMESCO Finland
Teaching
1.4
6.7
303
2232
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.4
6.7
272
1968
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.3
6.7
730
6108
D20
ICPC
Mouth/tongue/lip symptom/complaint
1.8
6.6
94
530
N06AB10
ATC
escitalopram; oral
1.3
6.6
491
3905
SPAT1058
SPAT
PEF monitoring instruction
1.6
6.6
144
913
D29
ICPC
Digestive symptom/complaint other
2.2
6.6
52
238
D19
ICPC
Teeth/gum symptom/complaint
1.3
6.6
645
5321
K62.4
ICD-10 Finland
Stenosis of anus and rectum
7.8
6.6
14
18
D12.4
ICD-10 Finland
Benign neoplasm: Descending colon
2.7
6.6
34
128
K29.7
ICD-10 Finland
Gastritis, unspecified
2.0
6.5
64
319
JFK10
NOMESCO Finland
Freeing of adhesions in intestinal obstruction
10.0
6.5
12
12
E87.6
ICD-10 Finland
Hypokalaemia
2.1
6.5
61
299
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
1.7
6.5
121
739
JFA76
NOMESCO Finland
Closure of fistula of small intestine
70.0
6.4
7
*
JAG43
NOMESCO Finland
Repair of stomal hernia with mesh
70.0
6.4
7
*
R60.9
ICD-10 Finland
Oedema, unspecified
1.8
6.4
92
521
XKD00
NOMESCO Finland
Uroflowmetry
1.4
6.4
245
1752
N20.1
ICD-10 Finland
Calculus of ureter
1.9
6.4
73
384
D06
ICPC
Abdominal pain localized other
1.5
6.3
172
1148
0093A
ICD-9 Finland
Ill-defined intestinal infections, Diarrhoea of presumed infectious origin
2.7
6.3
32
119
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.5
6.3
201
1388
JFH00
NOMESCO Finland
Total colectomy and ileorectal anastomosis
9.3
6.3
12
13
JFH31
NOMESCO Finland
Laparoscopic total colectomy, mucosal proctectomy and ileoanal anastomosis without ileostomy
+∞
6.3
6
*
56300
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Regional enteritis
+∞
6.3
6
*
45599
ICD-8 Finland
Haemorrhoids
2.6
6.2
33
126
E000001, ,
ATC
1.3
6.2
425
3341
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
2.0
6.2
60
298
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.5
6.2
177
1195
K07.4
ICD-10 Finland
Malocclusion, unspecified
2.3
6.2
44
193
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
2.4
6.2
39
162
R96
ICPC
Asthma
1.5
6.2
182
1237
Z93.3
ICD-10 Finland
Colostomy status
4.0
6.2
17
43
R01AD58
ATC
fluticasone, combinations; nasal
1.3
6.2
588
4832
N05CF02
ATC
zolpidem; oral
1.3
6.1
362
2784
R42
ICD-10 Finland
Dizziness and giddiness
1.3
6.1
405
3167
F51.0
ICD-10 Finland
Nonorganic insomnia
1.3
6.1
376
2909
TEA00
NOMESCO Finland
Biopsy of lip
3.3
6.1
22
67
K03.64
ICD-10 Finland
Dental calculus supragingival
1.3
6.1
753
6377
SDA02
NOMESCO Finland
Periodontal treatment, brief
1.2
6.1
795
6778
JGB31
NOMESCO Finland
Laparoscopic and perineal excision of rectum
12.5
6.1
10
8
XQ800
NOMESCO Finland
Prick test
1.5
6.1
170
1143
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.3
6.1
421
3317
N02AJ13
ATC
tramadol and paracetamol; systemic
2.2
6.0
45
202
R74
ICPC
Upper respiratory infection acute
1.2
6.0
791
6747

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
211
27
84.85
307.65
3.3
2.4
8.23
5.66
mg/l
2.04
178
22
1908
7755
6.26
307.65
7.7
4.5
37.09
36.07
g/l
16.01
1827
7232
1952
2229
30.73
307.65
6.4
1.3
218.53
79.75
ug/g
30.55
1825
1696
191
28
73.45
307.65
2.6
2.4
114.13
188.13
au/ml
—
37
7
1496
1769
18.20
307.65
1.9
1.2
—
—
—
0
0
1901
9705
4.42
271.10
11.5
5.9
—
—
—
0
0
1959
10351
4.46
262.62
10.9
5.5
0.04
0.04
e9/l
1.32
1796
9030
1956
10336
4.44
261.87
10.9
5.5
0.56
0.57
e9/l
1.23
1794
9029
2438
15404
8.58
255.46
14.2
6.7
71.96
75.76
u/l
7.05
2388
14552
1987
10724
4.44
255.39
11.1
5.8
0.19
0.19
e9/l
0.42
1835
9520
1969
10718
4.29
245.92
11.0
5.5
1.93
1.98
e9/l
0.71
1832
9582
1655
8150
3.76
237.18
3.4
2.1
74.97
74.64
nmol/l
0.20
1583
7459
1794
9358
3.86
234.08
11.3
5.6
0.73
0.67
%
6.17
1720
8774
1829
9692
3.89
232.22
11.2
5.6
2.91
2.83
%
0.74
1761
9109
1836
9766
3.89
231.46
11.6
5.9
8.48
8.36
%
0.91
1768
9191
1841
9986
3.78
221.07
10.7
5.4
56.12
56.63
%
1.21
1772
9425
1850
10127
3.76
217.58
11.3
5.6
29.20
28.78
%
0.99
1783
9564
2036
11906
4.10
215.35
12.7
8.7
3.90
4.06
e9/l
3.17
1858
10446
1123
4714
3.40
198.91
3.3
2.0
2.60
2.84
mg/l
3.14
1012
4033
2268
15268
4.44
172.92
6.6
3.7
10.27
10.41
mm/h
0.21
2151
14245
87
39
23.03
119.42
1.9
1.3
10.03
8.99
mg/l
0.52
74
32
1232
7002
2.42
105.31
4.5
3.1
27.89
33.77
u/l
1.87
1137
6692
382
1176
3.63
103.96
1.4
1.2
—
—
—
0
0
418
1443
3.25
94.43
5.4
3.9
0.42
0.71
%
1.98
121
436
440
1584
3.13
92.50
5.8
4.1
0.69
0.95
%
1.24
131
511
425
1509
3.16
91.42
5.9
4.2
0.07
0.11
%
0.69
116
436
410
1433
3.20
90.52
5.8
4.2
0.05
0.57
%
0.94
99
361
573
2424
2.74
89.41
2.5
2.5
23.73
24.24
%
0.36
495
2086
1515
9855
2.26
89.20
3.8
2.7
96.89
108.48
ug/l
1.35
1438
9225
635
2878
2.59
85.89
2.6
2.4
14.27
14.06
umol/l
0.26
600
2694
1444
9304
2.22
85.80
13.6
8.4
0.00
0.00
e9/l
1.35
1254
7621
597
2636
2.63
85.12
2.5
2.4
2.41
2.37
g/l
0.94
559
2451
644
2982
2.53
82.95
1.6
1.6
—
—
—
0
0
2560
21771
6.73
81.69
22.6
11.6
16.87
22.31
mg/l
19.18
2200
16847
1051
6094
2.20
79.78
3.8
2.4
56.99
57.75
u/l
0.21
996
5664
1502
10106
2.13
76.43
6.4
5.8
10.71
11.08
umol/l
0.55
1445
9582
1294
8354
2.08
72.06
2.4
2.0
—
—
—
0
0
207
536
4.11
71.43
1.4
1.2
84.21
91.64
titre
0.14
19
55
158
365
4.54
63.18
4.6
3.6
55.09
56.88
%
0.90
158
365
155
354
4.59
62.87
4.2
3.3
3.69
4.11
e9/l
1.85
155
354
772
4452
2.04
55.24
1.7
1.7
—
—
—
0
0
213
700
3.22
51.11
1.7
1.8
—
—
—
0
0
1841
14378
1.93
50.42
4.9
3.9
—
—
—
0
0
840
5121
1.94
50.39
8.9
6.5
—
—
—
0
0
2562
23050
4.73
48.37
23.3
13.1
74.82
74.70
umol/l
0.08
2562
23041
745
4418
1.96
48.12
1.5
1.4
2.36
2.32
g/l
0.18
483
2805
547
2966
2.06
45.15
1.5
1.3
494.88
504.04
titre
0.05
121
589
2563
23207
4.54
44.86
18.5
8.9
25.95
27.09
u/l
2.48
2539
22509
1085
7425
1.78
43.44
2.0
1.8
97.29
96.30
pmol/l
0.28
598
4002
1274
9155
1.76
42.86
6.9
6.4
1.22
1.21
mmol/l
1.71
1092
7812
282
1183
2.55
42.79
1.9
1.8
1.22
1.39
g/l
0.94
263
1097
333
1545
2.32
40.37
2.3
2.7
11.06
10.44
g/l
2.29
313
1419
535
3036
1.96
38.16
1.9
1.6
1066.12
1187.09
nmol/l
2.29
375
2369
172
593
3.03
37.88
1.3
1.1
—
—
—
0
0
789
5092
1.78
37.31
1.3
1.3
1.94
1.63
u/ml
0.17
184
1413
312
1461
2.29
36.87
3.1
2.7
5.55
5.63
e9/l
0.02
251
1261
343
1673
2.21
36.71
3.0
2.2
0.24
0.22
g/l
5.34
320
1563
2217
19191
1.97
35.29
24.1
14.0
14.48
14.75
%
0.50
2203
18843
2418
21641
2.39
34.91
18.1
12.9
139.56
139.64
mmol/l
0.98
2363
21067
2423
21720
2.40
34.59
18.1
13.0
3.92
3.95
mmol/l
8.64
2367
21100
1142
8299
1.66
34.27
12.8
12.0
1.14
1.20
inr
1.59
368
2507
138
448
3.20
33.65
1.2
1.2
249.02
257.45
u/ml
0.12
88
281
1136
8273
1.65
33.60
5.9
5.8
1.22
1.21
mmol/l
1.45
1056
7588
731
4765
1.74
32.61
4.5
4.1
—
—
—
0
0
110
329
3.45
30.60
1.1
1.2
—
—
—
0
0
815
5558
1.67
30.37
1.9
2.0
—
—
—
0
0
66
145
4.64
28.06
1.2
1.2
174.50
144.62
titre
0.15
20
26
782
5365
1.65
28.03
4.1
3.9
7.40
7.40
ph
0.22
135
1047
1655
13554
1.59
27.95
4.9
3.9
2657.65
1395.06
e6/l
0.20
23
179
1462
11641
1.57
27.84
4.9
4.5
6.47
6.58
mmol/l
1.32
1356
10768
393
2234
1.89
27.11
3.1
2.7
5.86
7.46
umol/l
1.51
349
1935
2493
23029
2.47
26.30
18.1
11.0
—
—
—
0
0
597
3873
1.70
26.25
2.1
1.6
105018999.79
39073271.12
pmol/l
0.93
538
3322
442
2648
1.80
25.67
1.2
1.2
—
—
—
0
0
187
820
2.38
25.50
1.2
1.2
—
—
—
0
0
100
323
3.18
24.61
1.8
1.6
0.69
0.85
g/l
0.95
78
248
1310
10349
1.53
24.57
3.9
3.3
0.00
0.00
estimate
0.80
303
1888
1299
10271
1.52
24.08
3.9
3.3
0.00
0.00
estimate
1.34
313
2040
721
5037
1.59
23.20
4.6
3.7
93.81
92.79
%
0.51
702
4920
83
256
3.31
22.04
4.1
3.4
0.85
1.44
%
1.46
74
238
1284
10247
1.49
22.00
5.2
4.4
0.00
0.00
estimate
0.50
300
1972
1075
8328
1.49
21.02
3.4
3.0
5.86
5.88
ph
0.11
74
803
322
1857
1.84
20.94
3.0
2.3
38.50
64.79
u/l
0.51
280
1586
597
4093
1.59
20.42
1.5
1.5
20.62
20.39
nmol/l
0.14
538
3586
2595
24755
3.77
20.26
31.1
17.2
6.74
6.72
e9/l
0.19
2572
24152
2592
24712
3.63
20.20
31.0
17.3
40.30
40.83
%
1.69
2436
23404
2594
24748
3.71
20.08
31.0
17.1
90.94
90.40
fl
8.17
2586
24457
2594
24750
3.70
20.04
30.9
17.1
30.28
30.20
pg
1.51
2586
24456
2594
24754
3.69
19.95
31.1
17.2
4.50
4.56
e12/l
7.95
2572
24156
2592
24728
3.60
19.85
31.2
17.2
266.66
254.60
e9/l
16.70
2571
24176
2594
24763
3.67
19.75
31.3
17.3
135.70
137.01
g/l
5.59
2585
24469
170
802
2.20
19.48
1.5
1.5
6.57
21.10
u/ml
—
10
18
333
1982
1.78
19.44
1.5
1.5
—
—
—
0
0
309
1823
1.79
18.55
1.2
1.2
—
—
—
0
0
125
539
2.38
17.70
2.9
2.8
—
—
—
0
0
54
149
3.68
17.05
4.0
3.2
52.17
55.04
%
0.42
47
135
728
5411
1.48
16.61
3.0
2.6
—
—
—
0
0
313
1969
1.67
14.79
2.2
2.1
335.82
377.27
nmol/l
3.54
288
1822
118
538
2.25
14.73
1.2
1.3
—
—
—
0
0
76
283
2.74
14.62
1.1
1.1
1.50
1.48
g/l
0.25
70
254
173
926
1.93
14.09
1.1
1.1
—
—
—
0
0
295
1852
1.67
14.03
2.7
2.7
1.71
1.76
%
0.32
265
1664
121
573
2.17
13.77
3.5
3.4
55.25
2579.59
u/ml
0.81
105
484
759
5860
1.41
13.62
3.5
2.9
—
—
—
0
0
754
5839
1.41
13.23
3.4
3.0
41.98
82.44
e6/l
1.42
614
4437
262
1636
1.67
12.69
3.1
4.2
17.80
23.49
ug/l
0.19
184
1309
499
3607
1.47
12.66
1.3
1.3
3.93
11.09
u/ml
3.60
172
1494
875
7000
1.37
12.48
3.9
3.4
83.75
81.30
e6/l
0.03
653
4790
594
4450
1.43
12.45
3.8
3.6
1.02
1.02
kg/l
0.25
88
614
1179
9901
1.34
12.20
2.9
2.5
—
—
—
0
0
280
1798
1.62
12.14
4.4
3.5
—
—
—
0
0
518
3805
1.45
12.03
1.3
1.3
16.03
27.65
iu/ml
5.01
161
1220
483
3520
1.46
11.66
3.4
3.3
581.55
463.04
ng/l
0.19
309
2429
700
5456
1.39
11.54
4.3
3.6
0.00
0.00
estimate
1.49
303
1912
1727
15435
1.34
11.29
3.8
2.9
44.88
43.11
u/l
0.38
1650
14641
392
2764
1.49
11.16
2.0
2.0
—
—
—
0
0
2109
19491
1.41
10.89
25.6
14.8
332.37
333.27
g/l
4.97
2103
19345
673
5254
1.38
10.89
3.2
2.8
—
—
—
0
0
678
5312
1.37
10.70
3.3
2.9
0.33
0.40
e6/l
0.45
543
3978
97
469
2.11
10.54
1.3
1.5
—
—
—
0
0
507
3804
1.41
10.32
2.9
2.7
547.31
550.19
mosm/kgh2o
0.10
437
3252
213
1336
1.65
10.13
2.8
2.7
70.66
71.89
e9/l
0.18
161
1000
527
4007
1.39
9.89
2.7
2.5
4.90
6.38
e6/l
2.28
485
3578
339
2388
1.48
9.64
1.8
1.7
—
—
—
0
0
606
4734
1.36
9.60
1.8
1.7
1.03
1.00
mg/l
0.07
471
3500
110
577
1.95
9.58
4.7
5.8
1.28
1.26
mmol/l
0.06
103
504
29
79
3.70
9.43
1.5
1.7
—
—
—
0
0
47
175
2.72
9.16
4.6
3.7
—
—
—
0
0
846
6983
1.31
9.12
3.4
3.1
64.07
51.41
ng/l
0.24
489
4205
88
434
2.06
9.12
1.4
1.5
109.49
114.52
u/ml
0.16
21
90
341
2435
1.46
9.02
1.5
1.4
—
—
—
0
0
40
138
2.93
8.97
1.1
1.1
—
—
—
0
0
239
1598
1.54
8.69
4.1
3.7
2.03
1.94
mmol/l
0.12
195
1325
94
486
1.97
8.57
1.6
1.4
280.22
301.01
ug/g
0.38
55
275
770
6318
1.31
8.56
3.2
3.2
2.35
2.35
mmol/l
0.14
675
5677
145
862
1.72
8.46
3.6
4.0
24.30
24.17
mmol/l
0.17
140
844
198
1284
1.59
8.24
4.0
4.0
83.34
84.73
ng/l
0.08
180
1155
2129
19950
1.35
8.17
4.9
4.5
1.66
2.04
mu/l
2.74
2019
18621
331
2394
1.44
8.16
5.6
6.0
1.03
1.04
mmol/l
0.18
311
2228
127
735
1.76
8.15
1.6
1.9
1.59
1.49
g/l
0.60
110
641
37
130
2.87
8.06
1.1
1.0
—
—
—
0
0
114
644
1.80
7.94
1.1
1.1
1.13
3.86
u/ml
—
9
97
34
115
2.98
7.92
1.1
1.1
1399.50
1589.21
miu/ml
0.40
34
115
51
215
2.40
7.77
1.4
1.3
—
—
—
0
0
236
1613
1.51
7.76
4.3
3.7
5.95
5.85
kpa
0.88
224
1562
50
212
2.38
7.53
1.4
1.3
0.32
0.37
g/l
0.88
35
150
50
212
2.38
7.53
1.4
1.3
2.92
3.01
g/l
0.14
36
152
398
3013
1.38
7.52
4.3
3.5
0.80
0.82
mmol/l
3.55
360
2847
777
6472
1.28
7.52
2.7
2.2
—
—
—
0
0
399
3024
1.38
7.49
3.1
2.7
2.74
2.57
e6/l
0.14
235
1607
574
4596
1.32
7.48
3.7
3.3
—
—
—
0
0
50
213
2.37
7.46
1.4
1.3
7.22
6.67
g/l
0.46
36
152
417
3197
1.36
7.27
2.9
2.5
0.82
1.12
e6/l
1.04
252
1769
57
261
2.21
7.20
3.1
2.6
6.46
111.50
u/ml
0.98
57
256
17
26
6.57
7.10
2.1
2.1
—
—
—
0
0
202
1362
1.52
7.09
1.4
1.4
—
—
—
0
0
36
136
2.67
6.90
1.8
1.6
—
—
—
0
0
1816
16815
1.26
6.66
4.1
3.9
14.63
14.56
pmol/l
0.64
1702
15556
216
1505
1.47
6.48
1.3
1.3
186.97
203.48
u/ml
0.12
200
1387
137
871
1.60
6.25
2.7
2.3
—
—
—
0
0
138
881
1.60
6.19
1.3
1.3
0.22
0.97
u/ml
—
9
82
245
1767
1.43
6.13
4.2
3.9
—
—
—
0
0
70
370
1.92
6.08
1.0
1.1
—
—
—
0
0
190
1310
1.49
6.02
2.9
2.7
230.15
164.06
ng/l
0.78
168
1181
586
4869
1.26
5.55
2.6
2.2
—
—
—
0
0
92
552
1.69
5.31
2.9
3.8
1.31
1.44
mg/l
1.26
83
517
188
1328
1.45
5.29
3.6
2.9
4.37
4.73
kpa
1.82
176
1282
13
23
5.67
5.06
1.8
1.5
—
—
—
0
0
659
5607
1.23
4.98
2.2
2.1
280.05
226.44
u/l
0.19
628
5309
28
113
2.49
4.79
2.8
3.3
—
—
—
0
0
11
17
6.49
4.77
1.1
1.0
—
—
—
0
0
104
664
1.59
4.74
1.7
1.7
1.20
1.18
g/l
0.29
97
624
202
1477
1.40
4.72
8.5
9.2
—
—
—
0
0
97
610
1.61
4.71
2.6
2.5
—
—
—
0
0
67
382
1.77
4.67
1.0
1.1
—
—
—
0
0
91
566
1.63
4.62
1.3
2.3
10.58
10.38
g/l
0.11
82
512
177
1270
1.42
4.61
3.2
2.4
—
—
—
0
0
30
128
2.36
4.57
1.1
1.4
4.71
8.30
ug/l
1.59
24
109
20
70
2.87
4.49
3.7
3.1
—
—
—
0
0
37
176
2.12
4.38
2.0
2.3
42.64
37.43
%
1.22
37
176
118
791
1.51
4.36
1.3
1.2
—
—
—
0
0
48
252
1.92
4.35
1.8
1.4
65.87
68.04
mmol/l
0.11
30
213
122
826
1.50
4.30
1.7
1.7
—
—
—
0
0
137
952
1.46
4.25
9.7
11.0
—
—
—
0
0
34
160
2.14
4.15
1.4
1.1
—
—
—
0
0
98
640
1.55
4.10
1.8
1.7
0.23
0.23
g/l
0.31
91
602
34
161
2.13
4.09
2.9
3.0
—
—
—
0
0
605
5204
1.21
4.01
3.6
3.4
—
—
—
0
0
256
2004
1.31
3.86
7.3
8.0
5.06
5.12
kpa
0.40
248
1915
256
2005
1.31
3.85
7.2
8.0
12.67
12.64
kpa
0.02
248
1917
255
1997
1.31
3.84
7.3
8.0
0.98
1.03
mmol/l
0.06
208
1572
215
1649
1.33
3.76
1.4
1.4
—
—
—
0
0
155
1129
1.40
3.75
4.4
4.9
—
—
—
0
0
78
494
1.60
3.75
2.5
3.7
7.42
7.42
ph
0.18
67
441
86
562
1.55
3.62
1.3
1.2
23.78
7.35
u/ml
—
10
95
173
1294
1.36
3.58
2.2
2.3
3735.87
5949.74
u/l
0.44
68
532
207
1593
1.32
3.55
7.2
7.5
1.33
1.38
mmol/l
0.27
201
1546
206
1588
1.32
3.49
7.8
8.1
8.73
8.79
mmol/l
0.05
196
1525
30
145
2.08
3.47
2.3
2.7
0.19
0.21
e9/l
0.45
25
129
75
482
1.57
3.42
2.6
2.2
—
—
—
0
0
518
4460
1.20
3.36
3.0
2.9
1653.33
1148.49
ng/l
1.00
437
3714
83
552
1.52
3.26
1.3
1.2
3.97
7.75
u/ml
—
9
57
30
149
2.03
3.25
2.5
2.7
505.16
545.47
e6/l
0.17
25
128
6
203
0.29
3.20
5.5
13.5
942.17
832.89
nmol/l
—
6
195
346
2876
1.23
3.20
2.6
2.2
29.36
29.64
s
0.40
335
2780
6
205
0.29
3.19
6.0
18.4
1395.17
1451.04
nmol/l
—
6
200
75
492
1.54
3.15
1.3
2.2
38.16
38.08
g/l
0.04
67
439
43
246
1.76
3.07
1.3
1.3
—
—
—
0
0
1511
14218
1.15
3.02
3.6
3.3
—
—
—
0
0
60
378
1.60
3.01
2.0
2.4
16.39
16.57
%
0.12
30
186
1998
19186
1.17
3.00
5.4
5.0
38.58
38.87
mmol/mol
0.62
1885
18044
381
3222
1.21
2.98
2.7
2.8
2.44
2.43
mmol/l
0.24
313
2835
36
197
1.84
2.98
2.3
2.7
1.33
1.22
e9/l
0.34
31
179
61
387
1.59
2.98
2.5
2.7
—
—
—
0
0
65
419
1.57
2.97
2.6
3.7
2.53
2.38
mmol/l
0.20
40
262
18
75
2.41
2.97
2.7
2.8
—
—
—
0
0
119
867
1.39
2.94
3.3
3.1
—
—
—
0
0
589
5196
1.17
2.86
3.3
3.3
606.93
326.48
mg/l
0.56
388
3411
663
5907
1.16
2.83
4.8
4.4
3.31
2.17
ug/l
0.40
596
5333
25
123
2.04
2.81
1.4
1.4
5.75
6.28
u/l
0.25
20
102
70
467
1.51
2.76
1.2
1.2
15.46
44.31
u/ml
—
5
44
667
5957
1.16
2.76
3.2
3.3
7.82
8.02
mmol/l
0.51
580
5154
312
2608
1.22
2.75
1.3
1.2
—
—
—
0
0
98
700
1.42
2.74
1.5
1.3
—
—
—
0
0
36
205
1.77
2.65
1.6
1.6
54.43
55.93
%
0.07
21
132
109
798
1.38
2.65
3.5
2.7
1.22
1.28
%
0.22
109
793
174
1367
1.29
2.63
2.2
2.6
67.25
66.89
g/l
0.24
163
1261
8
20
4.01
2.56
1.1
1.1
—
—
—
0
0
218
1771
1.25
2.52
2.3
2.2
12.10
12.72
nmol/l
0.49
196
1602
20
95
2.11
2.48
1.3
1.2
28.38
35.44
mmol/l
1.31
14
89
609
5444
1.15
2.46
3.9
3.9
10.14
9.56
mg/mmol
0.09
400
3559
55
360
1.54
2.41
1.4
1.3
2.72
4.94
u/ml
1.38
25
164
171
1358
1.28
2.40
1.4
1.4
25.07
24.82
iu/l
0.03
148
1156
59
394
1.51
2.36
3.0
2.2
7.18
5.41
umol/l
0.54
44
286
68
469
1.46
2.33
2.7
3.7
40.00
64.14
mg/l
0.97
61
378
51
331
1.55
2.33
2.3
1.7
—
—
—
0
0
142
1106
1.30
2.32
1.9
2.4
—
—
—
0
0
68
470
1.46
2.31
2.7
3.7
39.77
41.93
mg/l
0.07
61
378
28
155
1.82
2.29
1.3
1.2
—
80.47
—
0
9
14
59
2.38
2.29
1.0
1.0
—
—
—
0
0
116
881
1.33
2.27
1.9
1.7
—
—
—
0
0
19
92
2.07
2.27
1.1
1.1
—
—
—
0
0
188
1523
1.25
2.25
3.3
3.2
—
—
—
0
0
184
1487
1.26
2.25
3.5
3.4
1.23
1.23
mmol/l
0.25
172
1290
30
171
1.76
2.24
1.2
1.1
367.58
405.20
nmol/l
0.41
24
159
54
362
1.50
2.15
2.0
1.8
—
—
—
0
0
21
108
1.95
2.15
2.1
2.7
583.71
1109.78
u/ml
1.01
21
108
58
395
1.48
2.14
1.9
2.3
133.50
132.18
g/l
0.15
44
290
62
429
1.46
2.12
1.7
1.7
7323.96
13818.36
e6/l
1.58
47
319
18
88
2.05
2.11
1.8
3.3
92.90
130.06
umol/l
—
10
49
52
350
1.50
2.05
3.2
3.9
—
—
—
0
0
65
459
1.43
2.01
2.6
3.7
3.14
2.72
ratio
0.07
11
44
598
5411
1.14
2.01
1.6
1.6
1.39
1.39
mmol/l
0.02
528
4652
29
170
1.71
2.00
1.4
1.4
26.51
34.52
%
0.39
13
112
13
57
2.29
1.97
2.8
2.1
32.91
52.26
ug/l
2.17
13
57
142
1135
1.27
1.94
2.7
3.4
5.01
5.16
kpa
1.73
137
1089
5
11
4.55
1.94
2.2
2.0
—
—
—
0
0
29
172
1.69
1.93
1.2
1.3
4210.07
76697.02
e6/l
1.14
15
120
577
5227
1.13
1.90
2.7
2.5
5844.62
3979.54
umol/l
0.44
514
4681
172
1412
1.23
1.87
2.1
2.2
4.41
7.77
ug/l
4.25
146
1274
16
79
2.03
1.85
1.2
1.1
—
—
—
0
0
105
815
1.30
1.82
2.1
2.1
21.90
21.27
s
0.21
91
705
90
685
1.32
1.80
1.9
2.1
20.83
1.67
ug/l
0.58
76
614
257
2980
0.85
1.77
1.3
1.3
—
—
—
0
0
24
139
1.73
1.75
1.3
1.2
—
—
—
0
0
74
551
1.35
1.72
1.9
1.9
206.97
202.93
pmol/l
0.11
74
518
88
673
1.32
1.72
4.5
4.8
—
—
—
0
0
5
13
3.85
1.71
2.2
1.8
—
—
—
0
0
5
13
3.85
1.71
1.0
1.1
—
—
—
0
0
13
61
2.14
1.71
2.0
2.3
370.00
144.12
e6/l
—
7
34
51
357
1.44
1.70
1.0
1.0
1.06
2.61
u/ml
2.23
19
180
30
188
1.60
1.66
1.1
1.1
—
—
—
0
0
2107
20555
1.12
1.65
4.2
4.0
5.79
5.82
mmol/l
0.45
1977
19056
46
319
1.45
1.62
1.4
1.6
—
—
—
0
0
13
63
2.07
1.59
1.6
1.6
—
—
—
0
0
720
6671
1.11
1.59
1.6
1.6
—
—
—
0
0
140
1698
0.81
1.59
1.3
1.4
—
—
—
0
0
117
941
1.25
1.57
1.3
1.3
197.70
225.09
miu/ml
0.33
50
460
55
397
1.39
1.57
2.6
3.5
—
—
—
0
0
31
201
1.55
1.51
1.5
1.6
277.78
281.99
mosm/kgh2o
0.28
23
156
46
327
1.41
1.45
1.4
1.3
—
—
—
0
0
5
16
3.13
1.44
1.4
1.2
—
—
—
0
0
66
499
1.33
1.44
1.2
1.3
—
—
—
0
0
136
1126
1.22
1.43
2.7
3.4
7.42
7.41
ph
0.49
20
139
16
88
1.82
1.41
1.6
1.7
—
—
—
0
0
15
81
1.86
1.40
3.5
3.1
7.40
7.43
ph
—
8
23
22
134
1.65
1.39
1.1
1.2
—
—
—
0
0
44
314
1.41
1.37
2.5
2.4
—
—
—
0
0
53
392
1.36
1.34
2.4
3.0
8.55
8.37
kpa
0.33
53
384
13
68
1.92
1.33
1.2
1.5
72.00
95.83
nmol/24h
0.67
13
68
166
1414
1.19
1.31
3.7
3.4
4.52
4.56
pmol/l
0.26
151
1265
14
77
1.82
1.25
1.1
1.0
—
—
—
0
0
22
139
1.59
1.23
2.0
2.9
36.71
43.55
%
—
10
73
69
539
1.29
1.23
1.1
1.1
—
—
—
0
0
818
8656
0.92
1.20
2.5
2.5
—
—
—
0
0
307
2760
1.13
1.18
1.8
1.8
—
—
—
0
0
32
223
1.44
1.16
1.2
1.3
—
—
nmol/l
—
0
0
25
166
1.51
1.15
1.5
2.3
—
—
—
0
0
260
2319
1.13
1.14
1.6
1.4
—
—
—
0
0
23
151
1.53
1.11
1.9
2.2
9.53
11.52
%
1.21
23
151
22
143
1.54
1.11
1.0
1.1
15.24
10.62
iu/ml
—
5
40
76
611
1.25
1.10
1.1
1.2
—
—
—
0
0
14
81
1.73
1.09
5.1
5.2
—
—
—
0
0
20
128
1.57
1.08
5.3
7.4
—
—
—
0
0
333
3031
1.11
1.05
1.5
1.4
—
—
—
0
0
14
82
1.71
1.05
1.3
1.2
—
—
—
0
0
14
82
1.71
1.05
1.4
1.2
—
—
—
0
0
160
1390
1.16
1.04
1.3
1.2
—
—
—
0
0
32
229
1.40
1.03
1.3
1.3
—
—
—
0
0
23
154
1.50
1.03
1.2
1.1
1.06
1.05
ratio
—
8
57
41
307
1.34
1.02
2.5
2.8
—
—
—
0
0
51
395
1.30
1.01
1.3
1.2
—
—
—
0
0
37
273
1.36
1.01
2.1
2.6
—
—
—
0
0
30
214
1.41
0.99
3.6
5.0
102.41
81.78
u/ml
—
8
63
16
100
1.60
0.96
1.2
1.1
25.44
13.71
u/ml
—
7
65
17
108
1.58
0.96
45.6
35.4
6.96
7.64
ug/l
0.91
17
100
12
69
1.74
0.96
1.2
1.3
—
—
—
0
0
39
294
1.33
0.94
1.3
1.2
—
—
—
0
0
81
672
1.21
0.91
3.6
3.2
0.38
0.27
g/l
0.45
37
283
361
3329
1.10
0.90
1.8
1.7
—
—
—
0
0
23
160
1.44
0.88
1.2
1.1
—
—
—
0
0
16
103
1.56
0.87
1.0
1.0
732.60
697.98
ng/l
—
10
62
15
95
1.58
0.87
1.5
1.7
—
—
—
0
0
6
30
2.00
0.87
3.0
3.0
—
—
—
0
0
19
128
1.49
0.86
1.3
1.2
—
—
—
0
0
8
44
1.82
0.85
1.6
2.7
—
—
—
0
0
16
104
1.54
0.84
1.0
1.0
223.36
278.83
ng/l
0.72
11
63
33
248
1.33
0.83
1.4
1.5
—
—
—
0
0
14
89
1.58
0.81
4.1
3.2
—
—
—
0
0
46
365
1.26
0.80
1.1
1.2
—
—
—
0
0
28
207
1.36
0.79
2.8
2.6
—
—
—
0
0
6
33
1.82
0.79
1.7
2.0
—
—
—
0
0
26
190
1.37
0.79
1.4
1.3
158.49
216.75
pmol/l
0.55
26
190
0
26
0.00
0.78
0.0
1.3
—
742.29
—
0
7
0
27
0.00
0.77
0.0
1.0
—
—
—
0
0
0
27
0.00
0.77
0.0
8.0
—
—
—
0
0
36
278
1.30
0.77
1.3
1.6
—
—
—
0
0
51
412
1.24
0.77
4.1
4.0
—
—
—
0
0
22
157
1.40
0.76
1.0
1.0
—
—
—
0
0
19
132
1.44
0.76
1.9
2.2
1.82
1.83
u/field
0.00
11
70
25
183
1.37
0.75
3.0
2.4
—
—
—
0
0
22
158
1.40
0.74
1.3
1.3
—
—
—
0
0
50
406
1.24
0.73
1.2
1.4
22.81
22.57
u/l
0.02
42
340
5
25
2.00
0.72
2.6
2.7
0.40
0.80
u/field
—
5
25
5
25
2.00
0.72
1.2
4.0
20.46
27.50
g/mol
—
5
25
13
195
0.67
0.72
1.5
1.2
—
—
—
0
0
12
76
1.58
0.71
1.1
1.1
—
—
—
0
0
51
417
1.23
0.71
4.9
3.3
21.39
25.13
mg/l
0.57
35
262
5
26
1.92
0.70
2.2
3.2
—
—
—
0
0
5
26
1.92
0.70
6.4
6.2
—
—
—
0
0
5
26
1.92
0.70
1.0
1.1
—
—
—
0
0
20
143
1.40
0.70
1.1
1.1
—
—
—
0
0
9
58
1.55
0.69
3.0
2.3
—
—
—
0
0
14
93
1.51
0.69
1.3
1.2
—
—
—
0
0
28
214
1.31
0.66
4.8
2.2
—
—
—
0
0
68
797
0.85
0.65
1.4
1.4
—
—
—
0
0
22
164
1.34
0.62
1.0
1.0
—
—
—
0
0
94
824
1.15
0.62
2.7
3.5
—
—
—
0
0
2174
21491
1.07
0.61
4.1
3.9
4.67
4.72
mmol/l
1.61
2076
20311
13
88
1.48
0.60
1.2
1.1
—
0.04
g/l
—
0
5
8
51
1.57
0.60
1.3
1.1
—
—
—
0
0
69
800
0.86
0.59
1.4
1.4
—
—
—
0
0
2199
21756
1.06
0.58
4.4
4.3
2.76
2.83
mmol/l
2.24
2079
20421
46
383
1.20
0.57
1.2
1.6
—
—
—
0
0
6
36
1.67
0.56
1.5
1.1
—
—
—
0
0
35
284
1.24
0.55
1.3
1.4
—
—
—
0
0
15
107
1.40
0.55
1.7
1.8
2.00
4.98
u/field
—
10
84
94
833
1.13
0.55
1.3
1.4
7.86
8.89
u/l
0.49
75
692
30
240
1.25
0.53
3.5
3.0
0.80
0.84
nmol/l
0.16
23
185
11
74
1.49
0.53
1.5
2.3
—
—
—
0
0
41
341
1.21
0.52
1.3
1.5
—
—
—
0
0
72
821
0.87
0.52
1.5
1.5
—
—
—
0
0
11
157
0.70
0.51
1.1
1.1
—
—
—
0
0
23
180
1.28
0.49
1.6
1.5
—
—
—
0
0
15
110
1.37
0.48
1.3
1.2
—
—
—
0
0
102
919
1.11
0.47
11.1
10.9
23.93
24.31
mmol/l
0.50
95
897
18
233
0.77
0.47
1.1
1.4
—
—
—
0
0
113
1026
1.11
0.46
1.6
2.2
—
—
—
0
0
13
94
1.38
0.46
1.3
1.4
—
—
—
0
0
101
913
1.11
0.45
2.3
3.1
—
—
—
0
0
20
157
1.28
0.43
1.2
1.1
—
—
—
0
0
120
1098
1.10
0.43
10.3
10.4
0.62
0.68
%
1.17
120
1091
11
151
0.73
0.42
1.4
1.4
4296.00
72939.14
e6/l
—
5
93
11
79
1.39
0.40
1.5
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
11.30
—
0
18
21
169
1.24
0.38
1.1
1.1
—
—
—
0
0
52
457
1.14
0.38
1.0
1.1
—
—
—
0
0
123
1136
1.09
0.38
1.7
1.7
282.93
295.04
mu/l
0.19
114
1024
25
208
1.20
0.35
2.5
2.2
32.72
32.16
pg
0.19
25
208
6
44
1.36
0.34
2.2
1.4
2.20
3.06
mmol/l
—
6
37
19
154
1.24
0.34
1.9
1.4
87.16
75.92
umol/l
0.52
19
154
6
88
0.68
0.33
3.7
2.9
—
—
—
0
0
6
88
0.68
0.33
7.3
5.8
—
—
—
0
0
6
47
1.28
0.32
1.2
1.1
—
—
—
0
0
13
101
1.29
0.31
1.9
2.2
27.87
96.55
ug/l
0.43
13
91
118
1100
1.08
0.31
10.5
10.3
1.24
1.36
%
0.73
118
1094
115
1072
1.08
0.30
1.1
1.1
—
—
—
0
0
2153
21383
1.04
0.30
4.0
3.9
1.47
1.45
mmol/l
1.08
2050
20108
51
458
1.12
0.29
1.0
1.1
—
—
—
0
0
7
56
1.25
0.29
1.4
1.1
—
—
—
0
0
12
152
0.79
0.29
1.5
1.5
—
—
—
0
0
361
3485
1.04
0.29
2.8
2.8
0.66
0.71
ug/l
0.58
239
2140
24
204
1.18
0.28
1.1
1.4
—
—
—
0
0
13
162
0.80
0.28
1.0
1.0
0.50
2.67
u/ml
—
5
32
78
720
1.09
0.27
2.8
3.6
24.84
24.78
mmol/l
0.06
73
667
13
161
0.81
0.27
1.0
1.3
1.52
1.57
g/l
0.29
13
161
12
150
0.80
0.27
1.5
1.4
—
—
—
0
0
38
339
1.12
0.25
2.4
3.1
—
—
—
0
0
21
179
1.17
0.25
1.2
1.1
—
—
—
0
0
11
137
0.80
0.24
1.5
1.4
—
—
—
0
0
47
516
0.91
0.23
1.1
1.2
3.64
3.74
mmol/l
0.37
42
484
5
39
1.28
0.23
1.0
1.1
—
—
—
0
0
19
162
1.17
0.22
1.0
1.0
12.72
2.34
u/ml
—
7
50
5
40
1.25
0.22
1.0
1.2
—
—
—
0
0
5
40
1.25
0.22
1.0
1.2
—
—
—
0
0
5
40
1.25
0.22
1.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
46
502
0.91
0.21
1.3
1.5
70.94
138.05
pmol/l
1.03
46
491
15
126
1.19
0.21
1.2
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
8.0
—
210.00
—
0
9
164
1575
1.04
0.19
2.2
2.3
27.04
23.65
au/ml
0.13
17
134
49
452
1.09
0.19
1.4
2.3
0.79
0.85
nmol/l
0.25
42
388
30
270
1.11
0.19
1.4
1.6
7.81
7.57
mmol/l
0.24
30
259
15
175
0.86
0.18
1.5
1.4
3277.80
1800.41
e6/l
—
10
124
13
109
1.19
0.18
1.2
1.1
278.80
188.05
iu/ml
0.30
13
109
7
58
1.21
0.18
25.4
13.2
—
—
—
0
0
43
397
1.08
0.17
1.0
1.1
8.07
5.07
u/ml
0.23
15
155
21
186
1.13
0.17
1.5
1.2
3.53
0.75
u/ml
0.37
11
101
21
236
0.89
0.16
1.1
1.5
—
—
—
0
0
55
587
0.94
0.16
2.9
1.9
3.41
4.34
iu/l
0.96
22
223
137
1318
1.04
0.16
1.6
2.1
—
—
—
0
0
14
162
0.86
0.16
1.5
2.1
—
—
—
0
0
6
76
0.79
0.15
1.3
1.5
—
—
—
0
0
136
1310
1.04
0.15
1.7
2.2
—
—
—
0
0
127
1223
1.04
0.15
1.6
2.2
—
—
—
0
0
137
1323
1.04
0.14
1.6
2.2
—
—
—
0
0
134
1294
1.04
0.14
1.6
2.1
—
—
—
0
0
10
84
1.19
0.14
3.6
2.7
—
—
—
0
0
22
243
0.90
0.14
7.5
6.4
10.79
11.09
mg/l
0.12
22
226
43
456
0.94
0.11
2.5
2.4
103.29
125.70
ug/min
0.12
22
289
16
143
1.12
0.11
2.3
2.5
725.33
617.78
ml
—
9
97
11
126
0.87
0.11
1.0
1.4
—
—
—
0
0
38
357
1.07
0.11
1.3
1.4
7.04
7.10
mmol/l
0.04
30
321
5
46
1.09
0.09
1.2
1.1
—
—
—
0
0
5
46
1.09
0.09
1.2
1.1
—
—
—
0
0
5
46
1.09
0.09
1.2
1.1
—
—
—
0
0
5
47
1.06
0.09
1.6
1.3
62.28
69.18
mu/l
—
5
36
2066
20602
1.01
0.09
3.6
3.6
1.28
1.29
mmol/l
0.21
1951
19283
17
155
1.10
0.09
1.1
1.3
—
—
—
0
0
6
54
1.11
0.09
2.5
1.6
—
—
—
0
0
35
331
1.06
0.08
1.1
1.2
—
—
—
0
0
5
65
0.77
0.08
1.2
1.4
—
—
—
0
0
6
70
0.86
0.07
1.7
2.6
—
—
—
0
0
6
73
0.82
0.07
2.3
1.2
—
—
—
0
0
8
77
1.04
0.07
1.8
1.3
—
—
—
0
0
20
186
1.08
0.07
1.5
1.5
0.85
0.95
g/l
0.90
20
186
20
186
1.08
0.07
2.8
2.7
—
—
—
0
0
16
147
1.09
0.07
1.4
1.8
3.80
3.77
mg/l
0.01
16
141
35
367
0.95
0.07
1.0
1.0
0.49
0.37
u/ml
—
9
102
45
468
0.96
0.07
1.4
1.3
—
—
—
0
0
24
226
1.06
0.06
1.1
1.1
—
—
—
0
0
21
197
1.07
0.06
2.8
2.6
1.55
1.67
g/24h
0.07
12
103
147
1447
1.02
0.05
1.3
1.3
88.95
50.11
au/ml
—
6
78
48
467
1.03
0.04
1.3
1.5
0.38
0.42
nmol/l
0.13
42
383
51
497
1.03
0.04
1.1
1.1
1.58
1.99
u/ml
0.18
24
232
228
2293
0.99
0.02
4.1
4.0
31.96
31.66
%
0.15
164
1648
10
107
0.93
0.02
1.4
1.1
—
—
—
0
0
155
1561
0.99
0.02
1.6
1.7
—
—
—
0
0
118
1190
0.99
0.01
1.4
1.4
—
—
—
0
0
49
498
0.98
0.01
1.1
1.1
0.80
1.46
u/ml
0.51
19
203
51
518
0.98
0.01
1.1
1.4
201.98
35.82
e6/l
0.39
44
408
58
572
1.01
0.01
1.1
1.1
1.64
2.35
u/ml
0.34
24
286
13
136
0.96
0.00
1.3
1.8
—
—
—
0
0
16
166
0.96
0.00
1.0
1.0
0.44
0.92
u/ml
—
7
34
42
426
0.99
0.00
1.6
1.7
—
—
—
0
0
52
526
0.99
0.00
1.1
1.1
9.77
5.96
u/ml
0.51
22
278
57
565
1.01
0.00
1.7
2.9
—
—
—
0
0
38
381
1.00
0.00
1.1
1.1
19.57
1296.20
iu/ml
—
7
104
67
671
1.00
0.00
10.7
8.2
—
—
—
0
0
11
106
1.04
0.00
1.5
2.6
1716.82
2054.85
ml
1.18
11
94
17
166
1.02
0.00
1.4
1.9
5.74
6.38
mmol/l
1.16
11
114
176
1756
1.00
0.00
1.3
1.2
77.08
150.38
iu/ml
4.16
63
678
52
518
1.00
0.00
1.2
1.4
348.16
1421.76
e6/l
1.02
45
425
43
433
0.99
0.00
1.0
1.1
2.46
4.16
u/ml
0.76
17
199
48
477
1.01
0.00
1.1
1.4
—
—
—
0
0
12
117
1.03
0.00
1.2
1.4
139.92
138.10
nmol/l
0.10
12
117
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
2923.32
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
60
1.00
-0.00
1.2
2.1
18.70
16.45
umol/l
—
6
60
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
99
0.91
-0.00
1.1
1.4
119.89
168.64
mmol/24h
—
9
99
0
8
0.00
-0.00
0.0
1.4
—
2.36
—
0
8
9
93
0.97
-0.00
3.6
2.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
78
0.90
-0.00
2.3
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
4.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
72.60
—
0
5

Mortality – FinRegistry

Association

Association between endpoint ULCERPROCT and mortality.

Females

Parameter HR [95% CI] p-value
ULCERPROCT 1.073 [0.94, 1.23] 0.305
Birth year 0.992 [0.98, 1.0] 0.067

During the follow-up period (1.1.1998 — 31.12.2019), 443 out of 6386 females with ULCERPROCT died.

Males

Parameter HR [95% CI] p-value
ULCERPROCT 1.054 [0.94, 1.18] 0.354
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 674 out of 5681 males with ULCERPROCT died.

Mortality risk

Mortality risk for people of age

years, who have ULCERPROCT.

N-year risk Females Males
1 0.095% 0.217%
5 0.556% 1.228%
10 1.432% 3.08%
15 2.668% 5.909%
20 4.512% 9.884%

Relationships between endpoints

Index endpoint: ULCERPROCT – Ulcerative proctitis

GWS hits: 8

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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