autoimmune thrombocytopenic purpura: An autoimmune disorder in which the number of circulating platelets is reduced due to their antibody-mediated destruction. ITP is a diagnosis of exclusion and is heterogeneous in origin.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1160 |
4. Check minimum number of eventsNone |
1160 |
5. Include endpointsNone |
1160 |
6. Filter based on genotype QC (FinnGen only) |
1117 |
Control definitions (FinnGen only)
- Control exclude
- D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D69
- Name in latin
- Purpura idiopathica thrombocytopenica
Similar endpoints
↥List of similar endpoints to
Idiopathic thrombocytopenic purpura
based on the number of shared cases.
Similar with more cases:
- Purpura and other haemorrhagic conditions
- Coagulation defects, purpura and other haemorrhagic conditions
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9562 | 4823 | 4657 |
| Only index persons | 8094 | 4155 | 3939 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.13 | 0.14 | 0.13 |
| Only index persons | 0.15 | 0.15 | 0.15 |
| Median age at first event (years) | |||
| Whole population | 50.61 | 48.79 | 52.21 |
| Only index persons | 47.50 | 45.05 | 50.09 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1117 | 596 | 521 |
| Unadjusted period prevalence (%) | 0.22 | 0.21 | 0.24 |
| Median age at first event (years) | 51.17 | 43.01 | 60.50 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1160
- Matched controls
- 11600
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
XW000
NOMESCO Finland
Bone marrow biopsy
22.5
307.7
316
190
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
1078.4
307.7
612
12
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
+∞
307.7
1042
*
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
+∞
266.2
245
*
2873A
ICD-9 Finland
Purpura and other haemorrhagic conditions, Primary thrombocytopenia[PURPURA THROMBOCYTOPENICA IDIOPATHICA (ITP)]
+∞
136.2
128
*
H02AB06
ATC
prednisolone; systemic
4.3
122.0
788
3830
B02BX05
ATC
eltrombopag; oral
+∞
107.0
101
*
WW500
NOMESCO Finland
Blood transfusion
8.2
99.4
141
193
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.3
95.9
305
881
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
43.5
83.3
50
12
1517, ,
Kela drug reimbursment
+∞
78.0
74
*
3039, ,
Kela drug reimbursment
+∞
78.0
74
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.1
75.4
515
2381
ZX120
NOMESCO Finland
Intravenous
4.4
71.8
208
552
JMA10
NOMESCO Finland
Transabdominal total splenectomy
27.8
70.3
48
18
H02AB07
ATC
prednisone; oral
3.7
68.7
262
844
D59.1
ICD-10 Finland
Other autoimmune haemolytic anaemias
32.6
67.8
44
14
D69.4
ICD-10 Finland
Other primary thrombocytopenia
+∞
67.3
64
*
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
324.3
60.9
61
*
L04AX01
ATC
azathioprine; systemic
5.9
58.1
110
202
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.9
56.6
186
537
D69.9
ICD-10 Finland
Haemorrhagic condition, unspecified
101.7
53.3
58
6
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
15.9
46.2
40
26
D70.89
ICD-10 Finland
Neutropenic splenomegaly
11.6
45.1
47
42
6BA02, ,
NOMESCO Finland
100.1
44.1
48
5
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
4.8
41.6
98
218
D69.5
ICD-10 Finland
Secondary thrombocytopenia
400.5
39.3
39
*
1XC02, ,
NOMESCO Finland
14.6
37.5
34
24
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
37.5
598
3783
28710
ICD-8 Finland
Purpura and other haemorrhagic conditions, Thrombocytopenia essentialis (Morbus Werlhof)
+∞
36.7
35
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
6.2
35.9
63
107
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
9.5
35.8
43
47
D69.1
ICD-10 Finland
Qualitative platelet defects
357.6
35.1
35
*
6753
FHL
Transabdominal splenectomy
185.6
34.9
36
*
B02BX04
ATC
romiplostim; parenteral
+∞
34.5
33
*
3038, ,
Kela drug reimbursment
+∞
34.5
33
*
1516, ,
Kela drug reimbursment
+∞
34.5
33
*
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
10.1
34.0
39
40
L04AD01
ATC
ciclosporin; systemic
6.9
31.2
49
74
B02AA02
ATC
tranexamic acid; systemic
2.7
31.2
197
825
R50.9
ICD-10 Finland
Fever, unspecified
2.5
30.1
231
1060
A02BC02
ATC
pantoprazole; systemic
2.1
29.6
795
5904
28719
ICD-8 Finland
Purpura and other haemorrhagic conditions, Thrombocytopenia NUD
+∞
29.3
28
*
B02BX08
ATC
avatrombopag; systemic
+∞
27.2
26
*
D68.8
ICD-10 Finland
Other specified coagulation defects
35.0
26.6
34
10
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
26.6
366
2123
1524, ,
Kela drug reimbursment
+∞
26.1
25
*
3052, ,
Kela drug reimbursment
+∞
26.1
25
*
H02AB02
ATC
dexamethasone; systemic
2.6
25.9
161
666
H02AB09
ATC
hydrocortisone; systemic
5.2
25.8
54
108
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
25.7
25.4
35
14
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
23.3
331
1926
L04AA06
ATC
mycophenolic acid; systemic
6.0
23.2
41
70
D69.0
ICD-10 Finland
Allergic purpura
63.8
21.9
25
*
D64.9
ICD-10 Finland
Anaemia, unspecified
2.5
21.8
148
636
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
6.7
21.8
35
54
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
21.8
278
1552
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.5
21.7
155
682
J01MA12
ATC
levofloxacin; systemic
2.1
21.6
239
1265
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
7.8
20.9
29
38
R04.0
ICD-10 Finland
Epistaxis
2.7
20.5
114
444
A02BC01
ATC
omeprazole; systemic
1.9
20.4
335
2033
P01BA02
ATC
hydroxychloroquine; oral
2.7
20.3
114
446
M05BA04
ATC
alendronic acid; oral
2.7
19.9
117
469
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.4
19.8
73
224
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
6.1
19.6
34
57
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.0
19.3
90
318
M04AA01
ATC
allopurinol; systemic
2.3
19.1
169
815
120
Kela drug reimbursment
Hypogammaglobulinaemia
101.7
18.6
20
*
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
39.1
18.6
23
6
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
96.6
17.6
19
*
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
7.5
17.4
25
34
R59.9
ICD-10 Finland
Enlarged lymph nodes, unspecified
6.3
17.3
29
47
TGC00
NOMESCO Finland
Bronchial lavation
4.0
16.8
48
124
R23.3
ICD-10 Finland
Spontaneous ecchymoses
4.6
16.2
38
84
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.4
16.1
121
544
ZX112
NOMESCO Finland
Subcutaneous
4.2
15.9
42
102
A46
ICD-10 Finland
Erysipelas
2.1
15.8
173
905
WZC00
NOMESCO Finland
Treatment plan or consultation
1.7
15.7
411
2827
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.2
15.6
139
671
B01AB05
ATC
enoxaparin; parenteral
1.7
15.3
350
2315
C03CA01
ATC
furosemide; systemic
1.7
15.1
348
2307
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
6.2
14.7
25
41
JN4BD
NOMESCO Finland
Extensive body CT
2.2
14.7
132
639
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
+∞
14.6
14
*
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
11.0
14.5
27
25
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.9
14.4
217
1266
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
4.1
14.1
39
98
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.3
13.6
103
463
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.5
13.0
86
364
JN4AD
NOMESCO Finland
Body CT examination
2.2
13.0
121
594
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.9
12.8
190
1099
UJF32
NOMESCO Finland
Coloscopy
1.7
12.6
281
1831
J01MA14
ATC
moxifloxacin; systemic
2.2
12.6
107
506
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
11.1
12.5
23
21
J05AB01
ATC
aciclovir; systemic
1.7
12.4
247
1561
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.6
12.3
74
299
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
3.2
12.3
48
153
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
38.0
12.2
15
*
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.6
12.2
71
283
B01AA03
ATC
warfarin; systemic
1.8
12.1
215
1313
D46.9
ICD-10 Finland
Myelodysplastic syndrome, unspecified
21.5
12.0
17
8
JN3AD
NOMESCO Finland
Abdominal CT examination
2.0
11.9
129
670
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
11.8
248
1588
L03AA02
ATC
filgrastim; parenteral
3.4
11.7
41
122
M10.9
ICD-10 Finland
Gout, unspecified
2.4
11.7
84
370
D68.9
ICD-10 Finland
Coagulation defect, unspecified
65.6
11.6
13
*
D83.9
ICD-10 Finland
Common variable immunodeficiency, unspecified
65.6
11.6
13
*
WW200
NOMESCO Finland
Immunization
3.4
11.6
42
128
R79.8
ICD-10 Finland
Other specified abnormal findings of blood chemistry
11.2
11.6
21
19
D61.3
ICD-10 Finland
Idiopathic aplastic anaemia
+∞
11.5
11
*
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
11.4
577
4547
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.7
11.3
63
246
ZXD05
NOMESCO Finland
Urgent procedure
1.6
11.2
341
2397
B99
ICPC
Blood/lymph/spleen disease other
12.9
11.2
19
15
J01DB01
ATC
cefalexin; oral
1.7
11.1
920
8079
A05AA02
ATC
ursodeoxycholic acid; oral
4.3
11.1
28
66
R79.9
ICD-10 Finland
Abnormal finding of blood chemistry, unspecified
10.2
11.0
21
21
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
10.9
286
1935
D61.9
ICD-10 Finland
Aplastic anaemia, unspecified
43.7
10.9
13
*
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
43.7
10.9
13
*
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
5.5
10.9
21
39
R06
ICPC
Nose bleed/epistaxis
3.7
10.8
34
94
PJA10
NOMESCO Finland
Exploration of lymph nodes
4.6
10.7
25
55
D69.2
ICD-10 Finland
Other nonthrombocytopenic purpura
28.3
10.7
14
5
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.7
10.6
217
1376
A03
ICPC
Fever
1.7
10.6
197
1216
A41.9
ICD-10 Finland
Sepsis, unspecified
2.9
10.6
51
184
D07AB08
ATC
desonide; topical
2.0
10.5
129
699
2875A
ICD-9 Finland
Purpura and other haemorrhagic conditions, Thrombocytopenia, unspecified
+∞
10.4
10
*
L04AA01
ATC
[U] ciclosporin
5.2
10.3
21
41
D47.3
ICD-10 Finland
Essential (haemorrhagic) thrombocythaemia
7.5
10.2
23
31
A10AB05
ATC
insulin aspart; parenteral
2.1
10.2
94
459
J01FF01
ATC
clindamycin; systemic
1.6
10.1
288
1986
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.9
10.1
146
836
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
4.5
10.0
24
54
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.9
10.0
126
689
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.0
9.9
109
569
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.9
9.8
120
650
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
7.5
9.7
22
30
UJF30
NOMESCO Finland
Ileoscopy through colon
2.0
9.7
112
595
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
55.5
9.7
11
*
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
4.7
9.6
22
48
PJ2AT
NOMESCO Finland
Biopsy of lymphnode with ultrasound guidance
10.1
9.5
18
18
WZC30
NOMESCO Finland
Teaching
1.8
9.5
168
1021
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.3
9.5
72
325
D73.0
ICD-10 Finland
Hyposplenism
100.8
9.4
10
*
C81.0
ICD-10 Finland
Nodular lymphocyte predominant Hodgkin lymphoma
100.8
9.4
10
*
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
100.8
9.4
10
*
C90.0
ICD-10 Finland
Multiple myeloma
5.2
9.4
19
37
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
1.9
9.3
113
610
K83.0
ICD-10 Finland
Cholangitis
4.2
9.2
24
58
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
3.4
8.9
31
92
M01AE01
ATC
ibuprofen; systemic, rectal
0.7
8.9
806
8984
M35.1
ICD-10 Finland
Other overlap syndromes
12.6
8.9
15
12
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.0
8.7
89
452
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
14.2
8.7
14
10
122
Kela drug reimbursment
Aplastic anaemia
50.4
8.7
10
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
8.7
203
1330
J01MA02
ATC
ciprofloxacin; systemic
1.5
8.6
400
3050
A04AA01
ATC
ondansetron; systemic, rectal
2.1
8.6
87
441
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
8.5
378
2852
D59.9
ICD-10 Finland
Acquired haemolytic anaemia, unspecified
27.7
8.5
11
*
ZXE00
NOMESCO Finland
One hour or less
1.5
8.5
410
3147
E0000UV, ,
ATC
1.5
8.5
440
3424
AA1AD
NOMESCO Finland
CT of head and brain
1.5
8.5
279
1979
2873X
ICD-9 Finland
Purpura and other haemorrhagic conditions, Primary thrombocytopenia[THROMBOCYTOPENIA PRIMARIA NUD]
+∞
8.3
8
*
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
10.8
8.3
15
14
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
2.8
8.3
40
145
C03DA01
ATC
spironolactone; oral
1.8
8.3
134
793
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
4.1
8.3
22
54
E66.8
ICD-10 Finland
Other obesity
2.4
8.3
58
253
J01CA04
ATC
amoxicillin; systemic
1.5
8.3
907
8116
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
3.5
8.3
28
82
I82.9
ICD-10 Finland
Embolism and thrombosis of unspecified vein
3.7
8.2
25
68
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.2
8.2
68
319
Z3231
NOMESCO Finland
Registered nurse
1.5
8.2
289
2079
J01AA02
ATC
doxycycline; systemic
1.5
8.2
802
7005
K76.9
ICD-10 Finland
Liver disease, unspecified
4.8
8.1
18
38
JN6AD
NOMESCO Finland
CT of torso and neck
4.1
8.1
22
55
R16.1
ICD-10 Finland
Splenomegaly, not elsewhere classified
22.2
8.0
11
5
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.0
8.0
83
425
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
13.1
7.9
13
10
SPAT1255
SPAT
Intravenous administration of medicine
2.1
7.8
74
366
D68.3
ICD-10 Finland
Haemorrhagic disorder due to circulating anticoagulants
45.3
7.7
9
*
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.5
7.7
244
1712
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
7.6
514
4172
UJF92
NOMESCO Finland
Capsular endoscopy
3.2
7.6
29
92
N02AA05
ATC
oxycodone; systemic
1.6
7.5
178
1169
K29
ICPC
Cardiovascular sympt/complt other
2.4
7.4
48
202
PJD42
NOMESCO Finland
Excision of axillary lymph nodes
6.5
7.4
18
28
J47
ICD-10 Finland
Bronchiectasis
3.3
7.4
27
83
D62
ICD-10 Finland
Acute posthaemorrhagic anaemia
6.0
7.4
19
32
D46.7
ICD-10 Finland
Other myelodysplastic syndromes
10.9
7.3
13
12
B83
ICPC
Purpura/coagulation defect
+∞
7.3
7
*
D61.0
ICD-10 Finland
Constitutional aplastic anaemia
+∞
7.3
7
*
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
9.4
7.3
14
15
A10AC01
ATC
insulin (human); parenteral
1.9
7.3
89
483
Z2221
NOMESCO Finland
Medical doctor
1.5
7.2
283
2072
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
4.5
7.2
17
38
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
2.1
7.1
64
310
XF600
NOMESCO Finland
Bloodpressure measurement
2.0
7.1
74
379
K74.3
ICD-10 Finland
Primary biliary cirrhosis
8.8
7.1
14
16
318
Kela drug reimbursment
Teriparatide
10.1
7.0
13
13
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
7.0
421
3340
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
6.9
435
3472
H02AB04
ATC
methylprednisolone; systemic
1.7
6.9
143
905
M81.4
ICD-10 Finland
Drug-induced osteoporosis
13.9
6.9
11
8
ZX108
NOMESCO Finland
Inhalation
6.7
6.8
16
24
L01AA01
ATC
cyclophosphamide; systemic
9.4
6.8
13
14
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.5
6.8
300
2247
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
2.8
6.8
32
115
EBA15
NOMESCO Finland
Extraction of multiple teeth
2.4
6.8
44
186
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.1
6.8
59
283
D69.8
ICD-10 Finland
Other specified haemorrhagic conditions
40.3
6.8
8
*
TPH07
NOMESCO Finland
Cathetrisation of artery
1.7
6.7
119
722
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.5
6.7
199
1373
D75.9
ICD-10 Finland
Disease of blood and blood-forming organs, unspecified
7.2
6.7
15
21
9823/3-C42.1
ICD-O-3
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma of bone marrow
7.2
6.7
15
21
B01AB04
ATC
dalteparin; parenteral
2.2
6.7
52
238
ZXE10
NOMESCO Finland
More than one and less than three hours
1.4
6.7
362
2813
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
12.3
6.6
11
9
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
12.3
6.6
11
9
I80.1
ICD-10 Finland
Phlebitis and thrombophlebitis of femoral vein
3.4
6.6
23
69
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.8
6.6
101
589
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
1.8
6.6
99
574
B28
ICPC
Limited function/disability (B)
8.8
6.6
13
15
H05AA02
ATC
teriparatide; parenteral
10.1
6.5
12
12
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
3.0
6.5
27
90
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.7
6.5
128
800
ZXE20
NOMESCO Finland
More than three and less than five hours
1.6
6.5
139
888
B99
ICD-10 Finland
Other and unspecified infectious diseases
3.0
6.5
28
96
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
2.6
6.4
35
136
N02AX02
ATC
tramadol; systemic, rectal
1.4
6.4
427
3432
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
2.5
6.4
37
148
TQW99
NOMESCO Finland
Other minor procedure on skin
2.1
6.3
56
270
N05CF01
ATC
zopiclone; oral
1.4
6.3
317
2424
M10.0
ICD-10 Finland
Idiopathic gout
2.5
6.3
39
161
N02BE01
ATC
paracetamol; systemic, rectal
1.5
6.3
959
8824
H03AA01
ATC
levothyroxine sodium; systemic
1.5
6.3
223
1596
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.5
6.3
182
1249
C91.9
ICD-10 Finland
Lymphoid leukaemia, unspecified
18.1
6.3
9
5
K92.1
ICD-10 Finland
Melaena
2.1
6.3
59
292
D89.89
ICD-10 Finland
Other specified disorders involving the immune mechanism, not elsewhere classified
+∞
6.3
6
*
WE300
NOMESCO Finland
Profylactive therapy of malignancy with biomoidiers
+∞
6.3
6
*
R05
ICPC
Cough
1.5
6.2
242
1764
D73.1
ICD-10 Finland
Hypersplenism
26.8
6.2
8
*
H26.3
ICD-10 Finland
Drug-induced cataract
7.1
6.2
14
20
A03FA01
ATC
metoclopramide; systemic, rectal
1.5
6.2
212
1506
B03BA03
ATC
hydroxocobalamin; parenteral
2.1
6.2
59
293
XF400
NOMESCO Finland
ECG with 12 standard connections
1.6
6.2
160
1070
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
6.2
412
3307
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.8
6.2
93
539
ZX114
NOMESCO Finland
Intramuscular
3.6
6.2
20
57
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.5
6.1
243
1778
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
6.1
438
3555
A02BC03
ATC
lansoprazole; oral
1.4
6.1
279
2097
WW300
NOMESCO Finland
Transfer of autologic stem cells
12.6
6.1
10
8
J17.3*B59
ICD-10 Finland
Pneumonia due to Pneumocystis carinii
8.6
6.1
12
14
D07AC01
ATC
betamethasone; topical
1.4
6.1
352
2760
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.5
6.1
172
1175
QX3HE
NOMESCO Finland
Ultrsound examination of lesion close to skin
3.5
6.0
20
58
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
226
135
20.55
279.74
1.4
1.4
—
—
—
0
0
494
967
8.16
265.85
7.2
3.8
260.70
255.55
u/l
0.12
481
918
484
1020
7.43
239.77
5.8
2.4
2.01
1.76
%
3.95
446
920
408
762
7.72
225.81
5.3
2.3
83.20
69.74
e9/l
6.19
320
597
376
697
7.50
208.14
4.5
2.7
10.70
10.47
g/l
0.33
353
641
214
215
11.98
194.56
2.9
1.5
—
—
—
0
0
308
554
7.21
173.18
2.3
1.6
1.28
1.49
g/l
0.56
283
511
177
266
7.67
115.49
2.9
3.4
3.27
3.65
g/l
2.25
169
256
867
4793
4.20
104.78
13.7
5.5
1.94
1.95
e9/l
0.00
818
4230
202
388
6.09
103.52
2.6
1.9
1.14
1.52
g/l
6.59
171
345
817
4368
3.94
103.12
14.2
5.6
2.44
2.88
%
7.46
794
4085
831
4517
3.96
101.70
14.4
5.7
28.71
28.23
%
0.49
808
4247
823
4446
3.93
101.66
13.4
5.5
56.20
56.90
%
0.73
799
4177
862
4817
4.07
100.79
14.3
5.8
0.17
0.19
e9/l
5.47
811
4232
75
43
18.58
92.81
3.8
1.9
—
—
—
0
0
75
43
18.58
92.81
3.9
1.9
—
—
—
0
0
382
1379
3.64
86.25
2.8
2.4
29.52
29.71
s
0.19
366
1330
125
176
7.84
85.75
6.3
5.7
758.27
341.46
iu/ml
0.54
22
24
876
5368
3.58
79.48
20.5
8.4
3.99
4.13
e9/l
1.02
827
4674
101
136
8.04
71.77
3.2
3.9
936.67
2536.10
u/ml
—
6
10
101
139
7.86
70.43
1.4
1.2
4.20
4.40
u/ml
0.02
49
43
231
674
4.03
70.01
7.9
3.8
0.39
0.58
%
1.03
129
223
238
715
3.93
69.16
3.3
2.6
66.53
66.33
g/l
0.14
225
645
426
1906
2.95
64.17
2.3
1.4
2.45
2.36
g/l
0.35
330
1153
129
254
5.59
63.40
3.4
2.9
193.27
186.01
%
0.37
124
243
65
57
12.02
63.35
2.9
2.3
—
—
—
0
0
113
198
6.22
62.76
1.3
1.4
—
—
—
0
0
105
185
6.14
57.91
1.3
1.5
129.00
100.44
u/ml
0.74
20
29
754
4698
2.73
57.26
11.5
5.9
12.59
11.95
umol/l
0.50
735
4442
104
191
5.88
54.91
1.3
1.4
345.18
266.11
u/ml
0.61
60
108
126
284
4.86
52.83
3.9
1.5
0.19
0.24
g/l
5.99
116
269
60
63
9.99
51.64
3.1
2.2
0.20
0.21
e9/l
0.05
50
53
86
140
6.55
51.22
1.4
1.2
4.40
3.95
u/ml
0.14
50
60
127
296
4.70
51.08
3.8
1.5
1.08
1.18
g/l
3.10
119
282
60
66
9.53
49.89
3.1
2.2
575.18
603.26
e6/l
0.06
49
54
443
2249
2.57
49.66
6.6
4.0
89.63
89.46
%
0.04
431
2189
81
136
6.33
46.75
5.5
3.3
0.75
1.19
%
0.69
74
124
74
117
6.69
45.26
4.1
1.5
33.23
32.59
pg
0.59
74
117
705
4548
2.40
45.04
10.1
6.9
1.21
1.21
mmol/l
1.61
590
3864
434
2265
2.46
44.95
4.4
2.7
3477.50
6590.88
umol/l
0.85
402
1978
292
1261
2.76
44.78
3.2
2.4
23.12
22.50
%
0.27
267
1082
126
327
4.20
44.00
2.3
2.5
3.36
3.55
g/l
0.93
116
292
303
1345
2.70
43.93
3.1
2.4
2.39
2.34
g/l
0.86
290
1251
320
1461
2.64
43.83
3.3
2.4
13.39
13.13
umol/l
0.24
310
1360
126
328
4.19
43.82
2.3
2.4
6.76
7.41
g/l
4.31
116
292
126
328
4.19
43.82
2.3
2.4
—
—
—
0
0
317
1447
2.64
43.38
4.6
3.6
0.81
0.82
mmol/l
0.29
304
1360
48
49
10.18
42.08
1.3
1.2
—
—
—
0
0
118
311
4.11
40.28
2.4
2.5
2.74
3.01
g/l
2.12
108
275
121
326
4.03
40.08
1.5
1.2
1.29
1.34
u/ml
—
7
23
646
4143
2.26
40.01
9.1
6.2
1.21
1.21
mmol/l
1.05
602
3776
926
6971
2.63
38.84
15.0
7.1
83.17
79.70
u/l
1.16
901
6536
109
279
4.21
38.67
4.2
1.9
—
—
—
0
0
439
2436
2.29
38.23
2.8
2.2
3.29
2.94
mg/l
1.59
401
2058
61
97
6.58
37.05
2.5
2.1
—
—
—
0
0
638
4161
2.19
36.74
18.3
14.8
1.26
1.26
inr
0.07
219
1264
580
3651
2.18
36.48
2.2
2.0
94.86
95.09
pmol/l
0.04
362
1885
103
265
4.17
36.25
3.7
3.4
48.19
76.36
mg/l
0.59
83
214
102
261
4.19
36.16
3.6
3.3
3.24
1.86
ratio
—
8
24
103
266
4.15
36.07
3.6
3.4
38.10
33.24
mg/l
0.29
83
216
602
3862
2.16
35.87
8.0
4.8
34.91
35.59
g/l
2.31
579
3592
111
304
3.93
35.86
2.3
2.5
10.96
10.32
g/l
0.50
101
267
262
1227
2.47
32.97
7.9
6.0
1.05
1.06
mmol/l
0.12
246
1142
103
285
3.87
32.75
2.4
2.7
1.08
1.14
g/l
0.06
88
248
388
2160
2.20
32.48
1.8
1.5
18.42
20.57
nmol/l
2.29
356
1816
39
43
9.35
32.26
4.9
2.0
1316.51
1258.67
u/ml
0.03
39
43
201
869
2.59
29.72
2.6
2.1
354.28
373.06
nmol/l
0.37
189
805
92
252
3.88
29.63
2.5
2.6
0.07
0.02
g/l
0.32
85
229
40
52
7.93
29.04
1.3
1.1
1.05
1.07
ratio
0.34
16
20
874
6751
2.19
29.00
6.9
4.0
14.04
11.98
mm/h
3.05
836
6206
56
106
5.50
28.46
1.6
1.2
68.20
62.80
u/ml
—
6
6
50
85
6.10
28.41
5.6
3.4
47.48
53.39
%
0.92
42
76
195
850
2.56
28.26
3.9
2.3
0.20
0.21
g/l
1.32
189
798
83
219
4.00
28.15
1.7
1.2
3.54
2.96
u/ml
0.20
16
24
83
224
3.91
27.28
1.7
1.2
13.11
10.96
u/ml
0.08
26
33
611
4210
1.95
27.12
4.0
2.8
180.75
115.37
ug/l
2.07
589
3866
73
180
4.26
27.10
1.6
1.2
42.36
25.61
u/ml
0.47
25
13
86
240
3.79
26.95
1.7
1.2
6.23
18.15
u/ml
—
6
10
73
182
4.21
26.71
5.9
3.7
54.41
57.52
%
1.11
73
182
71
174
4.28
26.57
1.6
1.2
1.54
7.12
u/ml
—
8
13
738
5456
1.97
26.21
7.4
4.9
6.77
6.68
mmol/l
0.41
713
5074
351
2017
2.06
26.05
2.4
1.8
1.83
1.21
mg/l
1.04
276
1537
100
318
3.35
25.71
1.2
1.4
—
—
—
0
0
89
266
3.54
25.19
2.5
2.4
38.72
37.54
g/l
1.12
79
230
377
2252
2.00
24.92
3.7
2.3
—
—
—
0
0
82
237
3.65
24.40
2.6
2.6
0.00
0.00
g/l
-0.00
75
215
214
1036
2.31
24.36
5.3
2.9
11.16
7.80
umol/l
0.82
197
893
81
234
3.65
24.12
2.6
2.6
0.00
0.00
g/l
-0.00
75
214
33
44
7.69
23.43
4.6
3.4
—
—
—
0
0
61
147
4.32
23.32
1.3
1.2
97.08
36.83
u/l
0.96
56
126
33
45
7.52
22.99
1.5
1.1
76.67
11.00
u/ml
—
6
7
273
1499
2.07
22.47
2.3
1.8
—
—
—
0
0
294
1676
2.01
21.74
1.9
1.7
1222.43
1185.54
nmol/l
0.21
242
1267
40
76
5.42
20.24
1.3
1.1
356.00
95.00
titre
—
5
12
103
385
2.84
19.99
2.9
1.9
45.46
38.89
u/l
1.38
93
343
528
3708
1.78
19.90
2.8
2.3
74.76
76.04
nmol/l
0.50
485
3318
604
4424
1.76
19.55
4.0
2.6
—
—
—
0
0
36
64
5.77
19.54
1.3
1.4
—
—
—
0
0
485
3339
1.78
19.45
4.1
3.2
—
—
—
0
0
75
239
3.29
19.18
1.6
1.6
—
—
—
0
0
43
92
4.82
19.04
2.5
1.4
18.33
34.50
iu/ml
—
9
6
391
2562
1.79
18.30
3.7
3.1
0.29
0.46
e6/l
1.68
317
1953
72
232
3.24
18.09
1.7
1.6
—
—
—
0
0
163
792
2.23
18.08
11.0
7.6
9.44
9.48
mmol/l
0.02
154
756
35
68
5.28
17.29
1.3
1.1
—
—
—
0
0
35
68
5.28
17.29
1.3
1.1
—
—
—
0
0
38
80
4.88
17.15
1.3
1.7
—
—
—
0
0
35
69
5.20
17.02
1.3
1.1
—
—
—
0
0
35
69
5.20
17.02
1.3
1.1
—
—
—
0
0
35
69
5.20
17.02
1.3
1.1
—
—
—
0
0
59
176
3.48
16.74
1.7
1.7
—
—
—
0
0
412
2803
1.73
16.56
4.0
3.2
156.97
103.28
e6/l
0.33
337
2166
468
3304
1.70
16.38
4.6
3.7
73.86
112.52
e6/l
0.59
358
2318
31
57
5.56
16.25
2.7
2.7
38.02
43.18
%
0.67
21
31
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
79
290
2.85
15.84
3.8
4.8
0.32
0.36
u/ml
0.61
52
167
134
639
2.24
15.48
2.0
1.6
—
—
—
0
0
57
175
3.37
15.48
1.4
1.4
—
—
—
0
0
83
318
2.73
15.36
2.8
2.7
—
—
—
0
0
51
148
3.56
15.10
1.2
1.1
—
—
—
0
0
37
86
4.41
14.83
1.5
1.3
—
—
—
0
0
75
283
2.76
14.29
1.6
1.5
0.25
0.09
iu/ml
0.50
23
51
420
2964
1.65
14.22
5.8
3.3
42.51
32.71
u/l
0.62
402
2827
23
16
14.64
14.08
2.0
1.7
—
—
—
0
0
53
167
3.28
13.83
1.7
1.6
—
—
—
0
0
53
167
3.28
13.83
1.7
1.6
—
—
—
0
0
427
3048
1.63
13.70
4.1
3.2
2.33
2.35
mmol/l
2.65
386
2676
1039
9316
2.11
13.69
29.3
13.7
20.66
24.10
mg/l
3.10
909
7348
301
1964
1.72
13.61
3.2
2.5
5.04
5.89
e6/l
0.68
281
1756
401
2827
1.64
13.47
3.4
2.5
57.73
87.18
u/l
0.52
376
2613
143
738
2.07
13.46
4.8
3.3
1.22
1.23
mmol/l
0.86
128
635
45
132
3.51
13.13
1.4
1.5
—
—
—
0
0
184
1059
1.88
12.61
2.1
1.8
—
—
—
0
0
35
89
4.02
12.51
2.0
1.7
—
—
—
0
0
35
89
4.02
12.51
2.0
1.7
—
—
—
0
0
35
89
4.02
12.51
2.0
1.7
—
—
—
0
0
165
924
1.92
12.28
5.7
4.3
1.57
1.78
mmol/l
0.27
144
748
84
363
2.42
12.15
2.1
1.9
0.92
2.02
ug/l
0.67
77
321
24
46
5.31
12.04
1.0
1.0
—
—
—
0
0
180
1047
1.85
11.90
2.0
1.8
—
—
—
0
0
29
67
4.41
11.74
2.5
1.5
—
—
—
0
0
15
5
30.36
11.66
1.2
1.4
—
—
—
0
0
54
191
2.92
11.61
1.6
1.4
—
—
—
0
0
47
154
3.14
11.53
1.4
1.4
—
—
—
0
0
32
81
4.03
11.52
1.0
1.0
—
—
—
0
0
26
56
4.73
11.45
1.7
1.2
—
—
—
0
0
67
268
2.59
11.41
1.6
1.2
—
—
—
0
0
23
27
8.67
11.05
2.5
1.9
—
—
—
0
0
82
367
2.33
10.98
2.6
1.9
—
—
—
0
0
743
6216
1.54
10.96
5.4
4.4
63.85
1897.91
e6/l
1.20
13
92
34
94
3.70
10.85
1.9
1.9
—
—
—
0
0
231
1484
1.70
10.78
1.3
1.3
29.95
32.68
iu/ml
0.16
68
460
42
134
3.21
10.78
1.4
1.4
—
—
—
0
0
1038
9483
1.90
10.27
30.1
16.0
3.98
3.97
mmol/l
0.55
1020
9199
361
2627
1.54
9.99
3.7
3.1
1337.93
1410.50
ng/l
0.15
322
2253
162
962
1.80
9.94
3.8
3.3
—
—
—
0
0
42
141
3.05
9.92
1.5
1.5
—
—
—
0
0
1034
9457
1.86
9.88
29.5
16.0
139.50
139.60
mmol/l
0.66
1018
9191
19
36
5.35
9.65
1.2
1.3
—
—
—
0
0
19
36
5.35
9.65
7.6
2.8
197.68
201.39
u/l
0.09
19
36
35
109
3.28
9.36
1.9
1.8
—
—
—
0
0
20
25
8.12
9.36
1.4
1.0
75.50
93.46
%
1.54
12
13
234
1560
1.63
9.35
3.1
2.8
1.41
1.04
e6/l
0.55
146
909
104
546
1.99
9.30
1.5
1.5
—
—
—
0
0
280
1951
1.57
9.29
1.8
1.7
474.71
34907264.35
pmol/l
2.16
239
1610
18
19
9.60
9.28
1.2
1.2
—
—
—
0
0
364
2693
1.51
9.18
2.6
2.1
269.54
264.42
u/l
0.02
340
2546
811
7033
1.51
9.15
4.6
3.9
14.75
14.76
pmol/l
0.03
759
6365
16
14
11.57
9.08
1.6
3.9
—
—
—
0
0
49
190
2.65
8.92
1.8
1.3
—
—
—
0
0
183
1159
1.69
8.90
3.0
2.4
142.36
122.19
ug/g
0.43
153
916
19
24
8.03
8.87
1.3
1.0
73.27
96.50
%
1.42
11
12
21
47
4.53
8.86
2.2
1.9
—
—
—
0
0
21
47
4.53
8.86
2.2
1.9
—
—
—
0
0
35
113
3.16
8.85
1.3
1.6
—
—
—
0
0
72
336
2.22
8.77
2.3
1.8
—
—
—
0
0
15
13
11.67
8.58
1.5
1.2
—
—
—
0
0
165
1036
1.69
8.27
8.3
7.8
4.86
5.09
kpa
2.30
156
990
165
1037
1.69
8.24
8.3
7.8
0.70
1.15
mmol/l
0.82
136
816
165
1037
1.69
8.24
8.2
7.7
11.97
12.34
kpa
0.46
156
995
59
260
2.34
8.23
1.6
1.5
307.93
300.33
ug/g
0.10
30
162
61
273
2.30
8.21
1.4
1.6
—
—
—
0
0
561
4596
1.43
8.06
6.1
4.9
0.00
0.00
estimate
0.50
143
904
34
115
3.02
7.97
1.9
1.3
—
—
—
0
0
908
8158
1.52
7.81
38.0
16.3
15.46
14.80
%
2.81
899
8024
34
117
2.96
7.75
2.0
1.3
—
—
—
0
0
34
117
2.96
7.75
2.0
1.3
—
—
—
0
0
12
8
15.13
7.72
1.3
1.1
—
—
—
0
0
97
531
1.90
7.69
1.9
1.6
—
—
—
0
0
562
4631
1.41
7.68
4.6
3.6
0.00
0.00
estimate
0.50
147
957
215
1471
1.57
7.59
3.3
3.0
1.82
2.11
e6/l
0.31
128
824
33
114
2.95
7.48
2.0
1.4
—
—
—
0
0
33
114
2.95
7.48
2.0
1.4
—
—
—
0
0
33
115
2.92
7.37
2.0
1.3
—
—
—
0
0
114
666
1.79
7.36
6.7
5.0
1.38
1.76
mmol/l
0.59
82
486
47
197
2.44
7.34
2.7
2.3
124.21
129.72
g/l
0.80
34
149
36
133
2.76
7.23
1.2
1.1
—
—
—
0
0
561
4654
1.40
7.21
4.7
3.6
0.04
0.00
estimate
0.71
135
877
36
138
2.66
6.76
1.5
1.2
—
—
—
0
0
231
1649
1.50
6.65
3.1
3.0
2.44
2.45
mmol/l
0.51
213
1437
45
195
2.36
6.56
1.6
1.4
—
—
—
0
0
45
195
2.36
6.56
1.6
1.4
—
—
—
0
0
289
2162
1.45
6.55
1.4
1.3
2.96
1.82
u/ml
0.51
74
588
19
50
3.85
6.55
3.2
7.4
—
44.67
—
0
15
20
57
3.55
6.17
1.8
1.5
7.43
6.27
u/l
0.09
14
48
932
8539
1.47
6.16
24.7
12.6
82.51
82.23
ml/min/173m2
0.13
820
6954
927
8487
1.46
6.13
5.5
4.6
1.99
2.06
mu/l
0.17
877
7745
32
122
2.67
6.10
1.4
1.5
—
—
—
0
0
32
122
2.67
6.10
1.4
1.5
—
—
—
0
0
27
94
2.92
6.07
3.0
2.5
—
—
—
0
0
15
25
6.06
6.00
1.1
1.2
—
—
—
0
0
15
27
5.61
5.69
1.3
1.6
—
—
—
0
0
1042
9813
1.61
5.64
20.4
9.8
27.25
25.98
u/l
0.88
1023
9456
18
51
3.57
5.62
1.3
1.5
—
—
—
0
0
113
712
1.65
5.58
3.6
2.7
56.46
66.86
ml/min/173m2
1.91
59
280
110
689
1.66
5.55
4.8
4.3
91.95
86.11
ng/l
0.23
99
614
423
3456
1.35
5.54
5.3
3.6
166.84
51.73
ng/l
0.50
318
2386
31
123
2.56
5.49
1.1
1.1
—
—
—
0
0
18
52
3.50
5.46
1.3
1.5
—
—
—
0
0
12
17
7.12
5.44
1.4
1.0
—
—
—
0
0
59
308
1.96
5.44
1.8
1.8
—
—
—
0
0
16
33
4.90
5.44
2.5
2.2
—
—
—
0
0
16
33
4.90
5.44
2.5
2.2
—
—
—
0
0
25
89
2.85
5.43
1.4
1.1
53.96
85.78
u/l
0.58
25
84
689
6068
1.33
5.33
4.4
3.1
60.30
47.44
u/l
2.85
650
5657
199
1438
1.46
5.32
1.3
1.3
6.31
11.37
u/ml
0.95
65
546
16
34
4.76
5.31
2.6
2.1
—
—
—
0
0
22
75
2.97
5.16
1.4
1.5
—
—
—
0
0
40
185
2.20
5.08
1.7
1.5
—
—
—
0
0
48
241
2.03
4.95
1.5
1.3
—
—
—
0
0
95
591
1.66
4.94
1.5
1.3
327.63
204.26
u/ml
0.49
81
541
22
77
2.89
4.94
2.0
2.4
—
—
—
0
0
114
744
1.59
4.90
2.6
2.4
4.61
6.57
ug/l
1.54
104
657
25
96
2.64
4.75
1.3
1.1
92.00
94.21
%
0.13
25
90
19
63
3.05
4.68
1.3
1.4
—
—
—
0
0
59
326
1.85
4.63
1.2
1.3
202.56
254.75
miu/ml
0.43
16
148
317
2536
1.34
4.62
5.3
3.8
0.00
0.01
estimate
1.08
143
880
53
288
1.88
4.39
1.3
1.2
—
—
—
0
0
119
805
1.53
4.38
2.7
2.4
33.21
39.99
u/l
0.41
106
682
27
113
2.42
4.33
1.1
1.0
—
—
—
0
0
12
24
5.04
4.32
1.2
1.1
92.08
90.13
%
0.05
12
24
52
286
1.86
4.17
1.3
1.2
—
—
—
0
0
14
35
4.04
4.10
1.1
1.1
1218.43
1509.94
miu/ml
0.51
14
35
19
69
2.78
4.03
1.3
1.3
—
—
—
0
0
19
70
2.74
3.93
1.3
1.3
—
—
—
0
0
45
241
1.90
3.93
1.4
1.1
—
—
—
0
0
16
54
2.99
3.86
1.8
1.1
—
—
—
0
0
16
54
2.99
3.86
1.8
1.1
—
—
—
0
0
15
49
3.09
3.81
1.5
1.1
263.00
82.45
u/l
1.08
15
44
316
2590
1.30
3.78
4.1
3.3
1656.92
264.19
mg/l
2.13
232
1699
348
2890
1.29
3.77
4.4
3.2
7.58
7.73
mmol/l
0.24
302
2442
16
55
2.94
3.74
1.4
1.8
—
—
—
0
0
332
2743
1.29
3.74
4.9
3.9
10.44
9.44
mg/mmol
0.13
229
1760
111
768
1.49
3.70
3.2
3.4
205.58
201.74
ng/l
0.04
100
701
13
34
3.85
3.69
1.2
1.1
91.38
96.68
%
—
8
28
14
45
3.14
3.65
1.8
1.1
—
—
—
0
0
14
45
3.14
3.65
1.8
1.1
—
—
—
0
0
20
80
2.53
3.56
1.4
1.1
—
—
—
0
0
9
17
5.33
3.51
1.3
1.0
—
—
—
0
0
29
139
2.11
3.45
1.1
1.1
—
—
—
0
0
21
89
2.38
3.33
1.4
1.2
—
—
—
0
0
72
465
1.58
3.30
6.3
5.7
24.74
24.70
mmol/l
0.05
67
443
36
191
1.91
3.27
3.6
2.5
16.45
16.11
%
0.25
28
98
17
66
2.60
3.22
2.6
2.2
822.42
581.95
ml
0.97
12
38
6
8
7.53
3.05
4.8
6.1
—
—
—
0
0
21
93
2.28
3.04
4.7
3.9
—
—
—
0
0
8
17
4.73
2.92
1.8
1.4
—
—
—
0
0
6
9
6.69
2.87
1.2
1.0
—
—
—
0
0
78
532
1.50
2.83
4.5
3.4
4.34
4.61
pmol/l
1.37
71
472
13
47
2.79
2.82
1.3
1.1
33.38
14.69
u/l
0.88
13
42
9
23
3.93
2.77
1.0
1.1
—
—
—
0
0
18
78
2.33
2.75
1.3
1.5
26.67
31.33
%
0.19
12
52
5
6
8.36
2.75
1.0
3.0
—
—
—
0
0
36
205
1.78
2.68
3.3
3.2
0.71
0.84
nmol/l
0.89
23
162
10
31
3.24
2.52
1.2
1.4
—
—
—
0
0
408
3586
1.21
2.50
5.1
3.7
—
—
—
0
0
11
38
2.91
2.41
2.5
2.7
38418.18
40294.87
ug/l
0.17
11
38
39
235
1.68
2.41
1.4
1.4
—
—
—
0
0
34
201
1.71
2.26
1.6
1.6
25162.54
15235.26
e6/l
0.49
28
144
21
109
1.94
2.11
1.6
1.3
0.55
0.60
nmol/l
0.45
21
102
206
1717
1.24
2.08
4.8
3.8
296.13
419.94
ng/l
0.44
168
1321
5
10
5.02
2.07
1.0
1.2
—
—
—
0
0
659
6116
1.18
2.07
3.4
3.2
—
—
—
0
0
49
326
1.53
2.07
5.0
3.4
795.70
4356.42
u/ml
0.59
43
278
20
104
1.94
2.01
1.5
1.6
66.57
61.24
%
0.28
14
72
1069
10413
1.34
1.95
50.3
20.2
39.63
40.05
%
1.67
1016
9733
8
27
2.98
1.94
1.4
1.1
11.68
8.84
ug/l
—
8
27
6
16
3.76
1.93
1.5
1.3
—
—
—
0
0
1069
10415
1.34
1.92
50.2
20.1
177.78
250.53
e9/l
92.40
1054
10129
22
121
1.83
1.89
1.3
1.1
—
—
—
0
0
1069
10421
1.33
1.86
50.1
20.1
4.42
4.49
e12/l
4.21
1051
10113
8
28
2.87
1.86
1.3
1.4
—
—
—
0
0
1069
10422
1.33
1.85
50.1
20.1
7.20
6.79
e9/l
2.52
1054
10111
113
889
1.30
1.85
3.8
4.3
18.80
25.17
ug/l
0.19
98
732
5
12
4.18
1.82
1.0
1.5
—
—
—
0
0
1069
10425
1.32
1.82
50.4
20.2
131.85
135.05
g/l
9.49
1057
10254
14
66
2.13
1.82
1.1
1.5
—
—
—
0
0
70
522
1.36
1.66
1.4
1.3
—
—
—
0
0
34
222
1.55
1.61
2.9
2.2
149.50
98.68
ug/min
0.30
21
132
211
1812
1.20
1.60
1.6
1.6
—
—
—
0
0
137
1126
1.25
1.60
1.8
1.7
1.51
1.45
%
0.42
122
996
33
216
1.54
1.55
1.4
1.2
—
—
—
0
0
5
15
3.34
1.52
1.2
1.2
—
—
—
0
0
887
8534
1.17
1.45
4.3
3.8
1.38
1.27
mmol/l
4.00
822
7792
12
59
2.04
1.43
1.9
1.4
—
—
—
0
0
19
110
1.74
1.43
1.6
1.4
—
—
—
0
0
10
47
2.14
1.34
1.2
1.2
—
—
—
0
0
855
8231
1.15
1.28
6.7
5.6
40.03
39.80
mmol/mol
0.26
796
7607
10
48
2.09
1.28
1.2
1.1
410.38
183.14
iu/ml
—
10
48
11
55
2.01
1.27
1.0
1.1
—
—
—
0
0
921
8919
1.16
1.24
4.7
4.2
4.37
4.59
mmol/l
9.08
859
8256
6
25
2.41
1.24
3.2
1.4
120.17
85.28
nmol/24h
—
6
25
8
36
2.23
1.24
2.8
4.5
—
—
—
0
0
18
110
1.65
1.15
3.8
2.5
49.60
21.09
mg/l
—
5
26
5
20
2.51
1.15
1.6
1.4
—
—
—
0
0
12
67
1.80
1.05
2.3
1.6
0.99
0.97
g/l
0.12
12
67
58
729
0.78
1.02
2.7
1.9
—
—
—
0
0
7
35
2.01
1.00
1.0
1.2
—
—
—
0
0
11
186
0.59
0.96
1.6
1.7
—
—
—
0
0
7
37
1.90
0.94
2.3
2.2
65.41
100.19
ug/l
—
7
37
909
8858
1.12
0.87
4.6
4.2
1.36
1.45
mmol/l
8.07
846
8139
51
406
1.27
0.86
2.1
2.3
6867.30
4349.65
u/l
0.19
23
173
18
120
1.51
0.85
1.3
1.4
29.20
31.19
g/l
0.40
18
107
930
9080
1.12
0.84
5.2
4.7
2.57
2.72
mmol/l
5.93
874
8339
6
32
1.88
0.82
1.3
1.0
—
—
—
0
0
12
73
1.65
0.81
1.8
1.4
—
—
—
0
0
900
8780
1.11
0.79
5.2
4.4
6.05
5.93
mmol/l
1.02
832
7949
77
650
1.20
0.78
1.3
1.2
107.16
159.13
iu/ml
0.71
31
257
15
99
1.52
0.75
1.0
1.1
—
—
—
0
0
66
786
0.83
0.75
1.6
1.6
—
—
—
0
0
157
1745
0.88
0.74
2.7
3.0
0.73
0.76
ug/l
0.19
108
1137
7
39
1.80
0.72
1.0
1.0
—
—
—
0
0
14
92
1.53
0.72
1.0
1.1
—
—
—
0
0
7
42
1.67
0.68
1.1
1.0
—
—
—
0
0
20
144
1.40
0.68
1.1
1.0
2.06
1.94
u/ml
—
5
56
34
267
1.28
0.67
1.4
1.5
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
10
62
1.62
0.65
1.0
1.1
—
—
—
0
0
21
280
0.75
0.63
1.5
1.4
—
—
—
0
0
5
30
1.67
0.61
1.6
1.8
—
—
—
0
0
116
1296
0.88
0.61
2.2
2.1
—
—
—
0
0
8
50
1.60
0.61
2.8
2.2
—
100.13
—
0
8
15
105
1.43
0.60
1.0
1.1
—
—
—
0
0
224
2408
0.91
0.58
4.1
4.3
23.26
21.37
%
1.08
116
1162
105
1174
0.88
0.57
2.1
2.0
—
—
—
0
0
29
362
0.80
0.55
1.6
1.8
—
—
—
0
0
9
63
1.43
0.52
1.0
1.2
—
—
—
0
0
120
1089
1.11
0.50
4.4
4.4
29.94
32.52
%
1.56
90
737
12
84
1.43
0.49
1.2
1.2
1.64
3.00
u/ml
—
6
46
7
45
1.56
0.49
1.4
1.2
—
—
—
0
0
29
235
1.24
0.48
2.3
1.8
3.03
5.47
iu/l
1.47
17
77
7
48
1.46
0.47
1.0
1.1
—
—
—
0
0
7
50
1.40
0.45
3.3
2.3
—
—
—
0
0
15
112
1.34
0.44
6.4
1.9
13.32
13.11
%
0.27
15
112
10
69
1.45
0.44
2.1
1.4
88.40
78.48
umol/l
—
10
69
7
51
1.37
0.44
2.0
1.5
1.52
1.16
nmol/l
—
7
39
119
1091
1.10
0.43
11.9
7.1
—
—
—
0
0
29
239
1.22
0.43
1.7
1.4
604.34
462.10
mg/l
0.65
29
225
248
2347
1.07
0.43
1.8
1.7
1.34
1.35
mmol/l
0.06
206
1965
8
58
1.38
0.41
1.5
1.8
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
34
288
1.19
0.39
1.5
1.6
—
—
—
0
0
51
578
0.88
0.38
2.3
1.8
—
—
—
0
0
35
299
1.18
0.37
1.5
1.4
8.87
9.06
u/l
0.04
30
234
219
2076
1.07
0.37
5.3
3.9
1.02
1.02
kg/l
0.16
25
307
26
218
1.20
0.34
1.7
1.4
25.90
13.03
e6/l
0.22
21
167
6
47
1.28
0.32
1.3
1.1
17.45
35.87
nmol/l
—
6
40
44
389
1.14
0.32
1.3
1.4
—
—
—
0
0
7
56
1.25
0.29
1.6
1.3
—
—
—
0
0
133
1412
0.93
0.29
1.7
1.4
—
—
—
0
0
30
262
1.15
0.27
1.7
1.7
—
—
—
0
0
310
3003
1.04
0.25
4.6
5.0
2.20
2.87
ug/l
0.94
284
2658
9
76
1.19
0.24
1.2
1.0
—
—
—
0
0
17
143
1.19
0.23
1.1
1.1
—
—
—
0
0
10
79
1.27
0.22
1.2
1.1
214.00
228.18
mg/l
—
10
68
0
11
0.00
0.21
0.0
2.7
—
0.55
—
0
11
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
32
356
0.90
0.21
2.6
1.7
4.50
3.07
mg/l
0.43
23
259
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
10
121
0.82
0.18
1.5
1.4
6.33
7.06
mmol/l
—
10
104
5
66
0.76
0.17
1.2
1.2
—
—
—
0
0
29
317
0.91
0.15
1.4
1.4
—
—
—
0
0
29
317
0.91
0.15
1.4
1.4
—
—
—
0
0
29
317
0.91
0.15
1.4
1.4
—
—
—
0
0
29
316
0.92
0.14
1.4
1.4
—
—
—
0
0
47
500
0.94
0.13
1.0
1.0
—
—
—
0
0
32
345
0.93
0.13
1.4
1.5
—
—
—
0
0
65
680
0.95
0.11
2.1
2.1
10.51
12.30
nmol/l
1.24
58
599
6
56
1.07
0.08
1.0
1.4
1.39
1.54
g/l
—
6
56
16
149
1.07
0.05
1.6
1.6
—
—
—
0
0
23
223
1.03
0.01
1.3
1.5
—
—
—
0
0
59
597
0.99
0.01
1.5
1.5
—
—
—
0
0
17
174
0.98
0.00
1.2
1.8
195.94
210.23
pmol/l
0.19
17
164
36
364
0.99
0.00
2.1
1.5
292.40
289.20
mu/l
0.02
30
329
18
178
1.01
0.00
1.1
1.1
0.54
2.05
u/ml
—
8
103
21
208
1.01
0.00
1.4
1.1
1.53
3.77
u/ml
1.34
13
125
25
248
1.01
0.00
1.1
1.7
43.08
39.17
nmol/l
0.33
25
238
28
283
0.99
0.00
1.3
1.7
—
—
—
0
0
14
135
1.04
0.00
1.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
5
49
1.02
-0.00
1.0
1.0
7.84
7.46
kpa
—
5
44
0
6
0.00
-0.00
0.0
1.7
—
10.00
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
-0.00
1.0
1.0
229.20
241.13
ng/l
—
5
31
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
59
1.02
-0.00
33.0
18.2
1180.67
1490.37
nmol/l
—
6
59
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
57
0.88
-0.00
1.0
1.0
19.00
19.12
mmol/l
—
5
51
Mortality – FinRegistry
↥Association
Association between endpoint D3_ITP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ITP | 2.136 [1.84, 2.48] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.023 |
During the follow-up period (1.1.1998 — 31.12.2019), 792 out of 3356 females with D3_ITP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ITP | 2.157 [1.83, 2.54] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.035 |
During the follow-up period (1.1.1998 — 31.12.2019), 954 out of 3358 males with D3_ITP died.
Mortality risk
Mortality risk for people of age
years, who have D3_ITP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.16% | 0.403% |
| 5 | 0.979% | 2.627% |
| 10 | 2.315% | 6.513% |
| 15 | 4.587% | 11.842% |
| 20 | 8.251% | 20.907% |
Relationships between endpoints
↥Index endpoint: D3_ITP – Idiopathic thrombocytopenic purpura
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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