Bacterial meningitis

G6_MENINGBACT

bacterial meningitis: Inflammation of the membranes surrounding the brain and spinal cord due to a bacterial infection.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G0[0-1]
  • Hospital discharge: ICD-9 320
  • Hospital discharge: ICD-8 320
  • Cause of death: ICD-10 G0[0-1]
  • Cause of death: ICD-9 320
  • Cause of death: ICD-8 320

2 out of 7 registries used, show all original rules.

1304

4. Check minimum number of events

None

1304

5. Include endpoints

None

1304

6. Filter based on genotype QC (FinnGen only)

1304

Control definitions (FinnGen only)

Control exclude
G6_NEUINFL

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 13164 5855 7210
Only index persons 10528 4917 5611
Unadjusted period prevalence (%)
Whole population 0.19 0.17 0.20
Only index persons 0.20 0.18 0.21
Median age at first event (years)
Whole population 26.64 28.04 25.10
Only index persons 22.93 25.96 20.28

-FinnGen-

Key figures

All Female Male
Number of individuals 1304 680 624
Unadjusted period prevalence (%) 0.25 0.23 0.28
Median age at first event (years) 28.16 27.13 29.28

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1180
Matched controls
11799
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
32099
ICD-8 Finland
Meningitis, With no organism specified as cause
+∞
323.0
335
*
G00.9
ICD-10 Finland
Bacterial meningitis, unspecified
3082.4
277.2
257
*
32088
ICD-8 Finland
Meningitis, Alia definita
+∞
193.1
180
*
32000
ICD-8 Finland
Meningitis, H. influenzae
+∞
106.9
101
*
G01*A69.2
ICD-10 Finland
Meningitis (in) Lyme disease
+∞
96.2
91
*
G00.1
ICD-10 Finland
Pneumococcal meningitis
+∞
82.3
78
*
TAB00
NOMESCO Finland
Lumbar puncture
7.6
62.1
154
229
G03.9
ICD-10 Finland
Meningitis, unspecified
596.2
58.2
57
*
G01*A39.0
ICD-10 Finland
Meningococcal meningitis
+∞
40.9
39
*
A87.9
ICD-10 Finland
Viral meningitis, unspecified
28.6
38.4
52
19
G00.2
ICD-10 Finland
Streptococcal meningitis
+∞
28.2
27
*
AA1AD
NOMESCO Finland
CT of head and brain
2.3
27.0
305
1559
G00.8
ICD-10 Finland
Other bacterial meningitis
+∞
25.1
24
*
G00.3
ICD-10 Finland
Staphylococcal meningitis
+∞
25.1
24
*
A40.3
ICD-10 Finland
Sepsis due to Streptococcus pneumoniae
17.5
25.0
39
23
3209X
ICD-9 Finland
Bacterial meningitis, Meningitis due to unspecified bacterium
+∞
23.0
22
*
AAF00
NOMESCO Finland
Ventriculostomy
16.9
21.0
33
20
R51.80
ICD-10 Finland
Headache
2.4
21.0
203
948
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.0
20.9
128
460
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.4
20.1
193
899
G01
ICD-10 Finland
Meningitis in bacterial diseases classified elsewhere
+∞
19.8
19
*
G01*A32.1
ICD-10 Finland
Listerial meningitis
+∞
19.8
19
*
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
30.6
18.4
24
8
A69.2
ICD-10 Finland
Lyme disease
3.6
18.3
86
255
32010
ICD-8 Finland
Meningitis, Pneumococcus
+∞
16.7
16
*
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
9.4
15.7
32
35
G91.0
ICD-10 Finland
Communicating hydrocephalus
20.3
15.1
22
11
A39.0
ICD-10 Finland
Meningococcal meningitis
+∞
14.6
14
*
3200A
ICD-9 Finland
Bacterial meningitis, Haemophilus meningitis
+∞
14.6
14
*
G04.9
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis, unspecified
+∞
14.6
14
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.1
14.0
164
830
G00.0
ICD-10 Finland
Haemophilus meningitis
+∞
13.6
13
*
A86
ICD-10 Finland
Unspecified viral encephalitis
18.5
13.4
20
11
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.0
13.4
77
266
G96.0
ICD-10 Finland
Cerebrospinal fluid leak
50.6
12.9
15
*
04599
ICD-8 Finland
Aseptic mentingitis due to enterovirus, Aseptic meningitis, unspecified
32.4
12.6
16
5
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
19.1
11.6
17
9
N71
ICPC
Meningitis/encephalitis
+∞
11.5
11
*
3201A
ICD-9 Finland
Bacterial meningitis, Pneumococcal meningitis
+∞
11.5
11
*
G51.0
ICD-10 Finland
Bell palsy
4.1
11.4
43
107
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
3.5
11.2
52
155
N03AF01
ATC
carbamazepine; oral, rectal
2.8
10.3
66
246
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
10.0
440
3315
N03AX14
ATC
levetiracetam; systemic
3.8
9.9
40
107
G40.9
ICD-10 Finland
Epilepsy, unspecified
3.3
9.8
49
155
R50.9
ICD-10 Finland
Fever, unspecified
1.9
9.6
156
896
AAF99
NOMESCO Finland
Other shunt operation on ventricle of brain or intracerebral cyst
21.9
9.4
13
6
R51
ICD-10 Finland
Headache
2.6
9.1
66
266
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
5.7
9.1
25
45
N03AX16
ATC
pregabalin; oral
1.6
9.0
250
1680
N05CF01
ATC
zopiclone; oral
1.5
9.0
324
2323
N03AX12
ATC
gabapentin; oral
1.8
8.8
165
990
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
8.7
549
4426
XF400
NOMESCO Finland
ECG with 12 standard connections
1.7
8.7
172
1049
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
4.1
8.7
32
79
N03AF02
ATC
oxcarbazepine; oral
3.2
8.6
43
137
X59
ICD-10 Finland
Exposure to unspecified factor
1.7
8.5
204
1320
AA1BD
NOMESCO Finland
Extensive CT of head and brain
3.9
8.4
33
87
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
7.1
8.3
19
27
A41.9
ICD-10 Finland
Sepsis, unspecified
3.0
8.1
44
149
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.7
8.1
53
202
G63.0*A69.2
ICD-10 Finland
Polyneuropathy (in) Lyme disease
33.6
8.1
10
*
N03AB02
ATC
phenytoin; systemic
5.6
8.0
22
40
AAK40
NOMESCO Finland
Closure of cerebrospinal fluid fistula
45.3
7.7
9
*
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
7.7
212
1420
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.0
7.6
91
465
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
7.6
227
1551
G91.1
ICD-10 Finland
Obstructive hydrocephalus
11.9
7.6
13
11
N02AA05
ATC
oxycodone; systemic
1.8
7.4
131
771
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
6.0
7.4
19
32
H02AB06
ATC
prednisolone; systemic
1.4
7.4
470
3756
H66.0
ICD-10 Finland
Acute suppurative otitis media
2.2
7.4
72
339
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.1
7.4
83
415
J01DA01
ATC
[U] cefalexin; systemic
1.4
7.4
667
5681
N06AA09
ATC
amitriptyline; systemic
1.9
7.3
105
574
R42
ICD-10 Finland
Dizziness and giddiness
1.6
7.3
204
1365
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.5
7.2
54
222
I60.1
ICD-10 Finland
Subarachnoid haemorrhage from middle cerebral artery
10.1
7.0
13
13
G44.2
ICD-10 Finland
Tension-type headache
1.7
7.0
136
824
N02AX02
ATC
tramadol; systemic, rectal
1.4
7.0
431
3414
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
7.0
267
1927
N03AG01
ATC
valproic acid; systemic, rectal
2.1
6.9
76
377
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
6.9
278
2027
AA1AA
NOMESCO Finland
Head X-ray examination
6.7
6.8
16
24
WX882
NOMESCO Finland
High dependency care
3.2
6.8
34
110
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
6.8
217
1500
A32.7
ICD-10 Finland
Listerial sepsis
40.3
6.8
8
*
9560/0-C72.4
ICD-O-3
Schwannoma, NOS, of acoustic nerve
40.3
6.8
8
*
0499X
ICD-9 Finland
Other non-arthropod-borne viral diseases of central nervous system, Unspecified non-arthropod-borne viral diseases of central nervous system
16.8
6.7
10
6
SPAT1255
SPAT
Intravenous administration of medicine
2.1
6.6
69
335
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
5.5
6.6
18
33
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
1.9
6.6
94
516
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.8
6.6
112
653
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
4.4
6.6
22
51
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.1
6.5
66
317
XA800
NOMESCO Finland
Neuropsychological investigation
2.4
6.5
52
221
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
3.6
6.5
27
76
B94.80
ICD-10 Finland
Late effects of bacterial meningitis
70.2
6.4
7
*
AAE05
NOMESCO Finland
Nasoendoscopic closure of cerebrospinal fluid fistula
70.2
6.4
7
*
G50.0
ICD-10 Finland
Trigeminal neuralgia
4.2
6.3
22
53
WX730
NOMESCO Finland
Conventional respirator
3.9
6.3
24
63
J01FF01
ATC
clindamycin; systemic
1.5
6.3
283
2104
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.7
6.3
132
819
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
2.5
6.3
45
183
G02.0*B00.3
ICD-10 Finland
Herpesviral meningitis
+∞
6.3
6
*
G06.1
ICD-10 Finland
Intraspinal abscess and granuloma
+∞
6.3
6
*
N73
ICPC
Neurological infection other
26.8
6.2
8
*
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
26.8
6.2
8
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
6.2
174
1167
TKC20
NOMESCO Finland
Catheterisation of bladder
2.1
6.2
66
324
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
5.8
6.2
16
28
J01DB01
ATC
cefalexin; oral
1.4
6.1
898
8172
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.8
6.0
102
594

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
117
98
13.02
118.09
2.4
1.7
—
—
—
0
0
167
269
6.97
101.46
2.0
1.2
1309.6
487.5
mg/l
9.16
161
253
153
238
7.15
95.91
1.9
1.2
3.1
3.7
mmol/l
4.85
139
225
140
213
7.24
89.44
2.1
1.5
—
—
—
0
0
101
106
10.24
87.33
1.8
1.6
—
—
—
0
0
133
242
6.01
71.03
2.1
1.5
791.9
911.8
e6/l
0.07
111
195
133
242
6.01
71.03
2.0
1.4
432.5
8.3
e6/l
2.50
109
188
73
119
6.44
43.27
1.6
1.7
—
—
—
0
0
58
133
4.52
23.57
4.9
5.9
10.4
11.1
mg/l
0.49
53
120
160
739
2.33
19.93
3.0
2.4
37.5
21.2
au/ml
—
6
44
145
670
2.31
17.99
1.6
1.3
50.8
34.6
au/ml
—
8
30
28
45
6.34
16.78
2.6
1.1
35.5
65.6
%
—
16
5
399
2683
1.70
16.23
4.6
4.3
—
—
—
0
0
666
5409
1.47
10.55
6.6
6.5
9.9
11.4
umol/l
5.80
627
5155
19
37
5.20
9.37
1.3
1.4
—
—
—
0
0
22
49
4.55
9.32
1.1
1.2
—
—
—
0
0
659
5471
1.41
8.55
7.4
6.3
0.2
0.2
e9/l
1.12
591
4857
639
5283
1.41
8.46
7.1
5.9
0.6
0.6
e9/l
0.42
571
4605
561
4537
1.42
8.41
6.7
6.4
1.2
1.2
mmol/l
1.86
508
4133
640
5298
1.41
8.38
7.1
6.0
0.0
0.0
e9/l
1.18
570
4629
401
3067
1.44
8.13
2.4
2.1
142.6
247.5
u/l
2.47
383
2888
712
6023
1.40
8.11
5.6
5.1
6.7
6.7
mmol/l
0.05
669
5647
226
1543
1.56
7.96
2.0
2.2
29.5
29.8
s
0.24
220
1492
138
835
1.73
7.83
3.7
2.7
10.3
10.6
g/l
0.33
131
772
649
5435
1.39
7.69
7.1
6.0
2.0
2.0
e9/l
0.07
589
4834
13
22
5.96
7.38
1.0
1.0
15.2
6.4
mg/g
1.72
13
22
323
4191
0.70
7.26
2.6
2.7
—
—
—
0
0
39
150
2.65
7.25
1.4
1.3
77.2
62.4
mmol/l
1.12
30
132
596
4956
1.37
7.21
7.5
6.1
3.0
2.9
%
0.48
558
4637
602
5015
1.37
7.19
7.6
7.1
1.2
1.2
mmol/l
0.61
506
4248
416
3262
1.40
7.17
2.7
2.6
62.6
57.1
u/l
0.20
382
3044
525
4306
1.37
6.80
5.6
5.1
35.5
35.9
g/l
0.81
490
4036
217
1519
1.51
6.76
1.9
2.1
—
—
—
0
0
610
5129
1.36
6.71
7.5
6.2
28.5
28.1
%
0.32
566
4807
499
4077
1.36
6.56
9.8
8.6
1.2
1.2
inr
0.17
148
1190
594
4988
1.35
6.53
7.9
6.3
8.3
8.6
%
1.62
557
4698
574
4805
1.35
6.40
7.6
6.2
0.7
0.7
%
0.40
537
4508
706
6101
1.34
6.34
10.4
9.2
4.2
4.1
e9/l
1.05
629
5368
177
1214
1.53
6.04
2.0
1.7
—
—
—
0
0
597
5064
1.33
5.94
7.2
5.9
56.5
57.0
%
0.49
556
4770
867
7774
1.34
5.81
4.9
4.0
11.9
11.3
mm/h
0.52
819
7231
29
108
2.72
5.78
1.4
1.4
281.8
282.4
mosm/kgh2o
0.05
22
85
337
2631
1.38
5.76
4.1
4.0
93.4
91.7
%
0.64
332
2568
226
1652
1.45
5.62
3.4
3.7
0.8
0.8
mmol/l
0.31
214
1559
892
8066
1.34
5.43
9.0
7.6
77.4
77.6
u/l
0.05
854
7620
50
247
2.07
5.35
1.7
3.4
29.8
34.2
umol/l
1.06
41
214
27
104
2.63
5.08
1.9
8.8
8.0
7.2
mmol/l
0.16
17
85
429
3544
1.31
4.90
7.9
6.0
—
—
—
0
0
21
72
2.95
4.88
1.0
1.2
—
—
—
0
0
11
24
4.61
4.78
1.0
1.0
—
—
—
0
0
162
1146
1.47
4.76
8.5
9.3
0.9
1.2
mmol/l
0.50
132
905
142
979
1.51
4.74
4.1
4.2
—
—
—
0
0
463
3880
1.30
4.73
3.5
3.4
23.7
51.5
ng/l
1.98
313
2578
121
810
1.54
4.63
4.4
3.3
—
—
—
0
0
747
6676
1.28
4.51
5.6
4.1
791.7
2423.9
e6/l
0.71
14
98
146
1030
1.47
4.36
8.8
9.8
95.6
95.8
%
0.08
139
995
394
3271
1.29
4.23
2.5
2.3
—
—
—
0
0
158
1149
1.43
4.02
8.8
9.2
5.1
5.1
kpa
0.38
150
1105
158
1149
1.43
4.02
8.8
9.2
13.1
12.3
kpa
1.08
150
1108
290
2329
1.32
3.95
4.2
3.4
—
—
—
0
0
486
4184
1.26
3.80
2.1
2.1
—
—
—
0
0
161
1193
1.40
3.69
21.9
23.1
1.2
1.2
inr
0.05
23
167
14
45
3.13
3.65
1.2
1.1
1854.3
1586.2
miu/ml
0.31
14
45
134
965
1.43
3.61
2.5
2.5
34.1
85.0
u/l
0.52
118
828
464
3994
1.25
3.59
2.0
1.9
96.5
95.7
pmol/l
0.11
235
2102
53
308
1.75
3.58
2.2
1.6
0.2
0.2
g/l
0.27
48
293
95
640
1.52
3.58
10.7
8.5
24.8
24.5
mmol/l
0.35
86
600
65
400
1.66
3.57
2.7
2.1
1.4
2.0
ug/l
0.34
57
359
82
537
1.56
3.51
11.8
13.1
—
—
—
0
0
59
356
1.69
3.50
2.5
2.2
324.8
516.7
ug/l
0.49
53
337
177
1347
1.36
3.46
6.5
6.1
1.0
1.0
mmol/l
0.37
167
1248
133
965
1.42
3.45
9.7
10.0
119.6
122.4
g/l
0.82
126
933
191
1473
1.35
3.43
1.4
1.3
691.7
496.7
titre
0.64
41
305
67
421
1.62
3.41
1.3
1.2
0.3
1.2
u/ml
—
8
27
89
601
1.52
3.33
1.3
1.2
—
—
—
0
0
337
2817
1.26
3.32
3.4
2.9
—
—
—
0
0
14
48
2.94
3.30
2.2
3.2
869.0
1087.7
u/ml
0.26
14
48
316
2624
1.27
3.28
7.3
6.8
—
—
—
0
0
9
19
4.76
3.24
2.4
2.0
—
—
—
0
0
239
1920
1.30
3.22
3.5
3.7
238.0
448.8
ng/l
1.03
170
1434
5
5
10.03
2.98
2.4
1.0
—
—
—
0
0
52
321
1.65
2.88
2.2
1.6
1.2
1.2
g/l
0.37
47
304
258
2126
1.27
2.83
1.6
1.5
2.4
2.4
g/l
0.00
153
1339
269
2229
1.26
2.82
4.8
3.8
1.0
1.0
kg/l
0.36
48
311
772
7123
1.21
2.77
5.1
4.1
—
—
—
0
0
295
2476
1.25
2.76
2.3
2.1
3.0
3.0
mg/l
0.01
253
2115
6
10
6.02
2.70
1.2
3.6
—
—
—
0
0
139
1062
1.35
2.68
2.3
2.9
1.7
1.8
%
0.32
123
952
252
2089
1.26
2.63
3.4
2.5
4.6
5.7
e6/l
0.96
227
1854
106
779
1.39
2.60
2.1
3.0
68.6
72.6
e9/l
0.45
81
604
182
1452
1.29
2.59
1.2
1.2
—
—
—
0
0
15
62
2.44
2.54
1.1
1.0
227.7
294.5
ng/l
—
9
39
71
487
1.48
2.53
5.9
3.8
23.9
24.2
mmol/l
0.33
60
441
92
664
1.41
2.51
8.6
6.1
—
—
—
0
0
92
665
1.41
2.49
2.5
1.8
1.6
1.4
g/l
0.11
83
616
15
63
2.40
2.46
1.1
1.0
666.9
644.2
ng/l
—
10
40
49
312
1.59
2.44
10.7
8.8
1.4
1.3
mmol/l
0.16
41
276
215
1765
1.26
2.43
2.0
1.7
1111.0
1189.2
nmol/l
0.71
165
1348
33
189
1.77
2.43
2.8
4.3
157.8
1937.9
u/ml
0.75
28
180
321
2760
1.22
2.37
3.9
3.0
0.3
0.4
e6/l
0.77
244
2062
24
125
1.94
2.36
1.1
1.2
—
—
—
0
0
23
118
1.97
2.36
3.3
3.9
—
—
—
0
0
69
478
1.47
2.36
4.8
3.5
—
—
—
0
0
860
8074
1.19
2.34
4.2
3.9
14.6
14.7
pmol/l
0.92
786
7403
129
996
1.33
2.34
2.5
2.1
337.8
369.9
nmol/l
0.96
118
925
165
1325
1.28
2.24
2.6
2.4
149.4
125.1
ug/g
0.47
130
1073
349
3040
1.20
2.24
4.3
3.1
31.3
76.7
e6/l
1.25
274
2331
318
2746
1.21
2.24
2.9
2.7
1984.7
5632.3
umol/l
1.29
278
2414
403
3559
1.19
2.22
4.9
3.6
39.5
88.3
e6/l
2.24
286
2509
64
445
1.46
2.16
1.2
1.2
—
—
—
0
0
6
14
4.30
2.15
1.0
1.1
—
—
—
0
0
109
832
1.34
2.15
1.2
1.2
—
—
—
0
0
233
1961
1.23
2.12
3.3
2.7
558.8
558.6
mosm/kgh2o
0.00
204
1680
17
82
2.09
2.07
1.1
1.2
—
—
—
0
0
109
839
1.33
2.04
7.6
9.8
—
—
—
0
0
1108
10698
1.24
2.04
18.7
13.4
22.7
23.4
mg/l
0.28
917
8408
150
1206
1.28
2.04
2.6
2.8
5.3
8.4
umol/l
3.88
125
1054
539
4910
1.17
2.01
4.0
4.0
—
—
—
0
0
60
419
1.45
2.00
1.4
2.2
1.8
1.5
g/l
1.06
53
367
88
658
1.36
2.00
4.5
3.4
5.2
5.2
kpa
0.22
81
620
7
21
3.35
1.96
3.6
2.3
—
—
—
0
0
289
2505
1.20
1.94
2.7
2.3
—
—
—
0
0
158
1287
1.26
1.93
1.5
1.4
—
—
—
0
0
553
5062
1.16
1.91
4.1
3.4
0.0
0.0
estimate
0.00
90
947
46
309
1.51
1.87
1.4
1.5
262.4
283.6
ug/g
0.33
30
181
191
1596
1.23
1.87
3.5
2.8
2.2
2.5
e6/l
0.16
96
850
43
285
1.53
1.86
1.4
1.2
1.6
2.8
u/ml
—
6
29
495
4504
1.16
1.83
2.9
2.8
117.5
129.8
ug/l
0.68
457
4189
38
247
1.55
1.80
1.7
1.7
9754.5
13356.0
e6/l
0.38
33
188
17
87
1.97
1.80
1.1
1.2
—
—
—
0
0
277
2413
1.19
1.76
1.6
1.7
1.0
1.1
mg/l
0.63
210
1828
378
3384
1.16
1.72
3.8
3.5
2.4
2.4
mmol/l
0.12
328
3002
85
651
1.33
1.69
4.6
3.4
7.4
7.4
ph
—
9
88
154
1276
1.23
1.64
7.6
7.6
103.8
104.2
mmol/l
0.56
148
1244
97
760
1.30
1.64
3.7
3.9
76.6
84.9
ng/l
0.63
86
672
207
1771
1.20
1.61
1.3
1.3
5.1
13.2
u/ml
1.70
74
702
330
2939
1.16
1.60
4.2
4.1
7.4
7.4
ph
1.26
62
565
216
1857
1.20
1.59
1.4
1.3
18.5
31.8
iu/ml
2.39
67
590
6
20
3.01
1.58
2.0
2.2
23.0
17.5
umol/l
—
6
20
88
686
1.30
1.56
1.3
1.3
113.5
209.5
u/ml
1.49
83
634
47
331
1.44
1.56
2.1
2.3
1534.8
3395.9
u/l
0.77
16
133
122
993
1.25
1.54
4.0
4.5
13.6
23.1
ug/l
0.32
93
818
94
741
1.29
1.54
3.2
2.8
3.9
4.2
e9/l
0.58
64
599
35
233
1.52
1.53
12.7
10.1
103.5
105.5
mmol/l
1.25
29
211
35
233
1.52
1.53
12.7
10.1
11.4
11.5
mmol/l
0.06
29
211
5
15
3.34
1.52
1.6
1.0
—
—
—
0
0
5
15
3.34
1.52
1.6
1.0
—
—
—
0
0
5
15
3.34
1.52
1.6
1.0
—
—
—
0
0
29
185
1.58
1.52
1.4
1.6
—
—
—
0
0
33
218
1.53
1.50
7.4
3.3
—
—
—
0
0
258
2266
1.17
1.49
1.5
1.5
21.7
21.0
nmol/l
0.27
221
1946
21
124
1.70
1.47
1.6
1.2
—
—
—
0
0
42
293
1.45
1.47
1.1
1.2
—
—
—
0
0
304
2707
1.16
1.47
4.7
3.8
0.0
0.0
estimate
1.08
84
930
153
1287
1.21
1.43
1.6
1.6
—
—
—
0
0
551
5122
1.13
1.41
4.2
3.4
0.0
0.0
estimate
0.50
91
921
18
103
1.76
1.41
3.3
2.5
—
—
—
0
0
21
126
1.68
1.40
1.6
1.8
—
—
—
0
0
21
126
1.68
1.40
1.6
1.8
—
—
—
0
0
21
126
1.68
1.40
1.6
1.8
—
—
—
0
0
21
126
1.68
1.40
1.6
1.8
—
—
—
0
0
304
2717
1.16
1.40
4.0
3.0
—
—
—
0
0
90
717
1.27
1.38
1.4
1.4
—
—
—
0
0
305
2730
1.15
1.38
2.9
3.1
1368.8
1178.6
ng/l
0.14
260
2310
39
273
1.44
1.36
1.3
1.2
—
5.4
—
0
5
31
208
1.50
1.33
1.1
1.1
—
—
—
0
0
11
54
2.05
1.33
1.0
1.2
—
—
—
0
0
11
54
2.05
1.33
2.1
2.2
1.9
2.1
ug/l
—
6
46
544
5069
1.13
1.32
5.5
4.7
0.0
0.0
estimate
0.50
95
963
225
1976
1.17
1.31
1.8
1.8
—
—
—
0
0
40
284
1.42
1.30
1.1
1.1
—
—
—
0
0
5
18
2.78
1.28
1.8
3.5
—
—
—
0
0
15
84
1.79
1.27
1.4
1.1
—
83.9
—
0
6
168
1446
1.19
1.25
2.8
2.5
2.3
2.3
g/l
0.03
163
1349
20
123
1.64
1.24
1.8
1.5
—
—
—
0
0
20
123
1.64
1.24
1.4
1.7
52.9
57.2
%
0.15
15
90
17
100
1.71
1.23
2.0
2.2
1.7
1.1
e9/l
—
6
54
53
401
1.34
1.20
7.8
5.0
—
—
—
0
0
6
26
2.31
1.18
35.0
6.8
—
—
—
0
0
19
117
1.63
1.18
1.1
1.7
—
—
—
0
0
112
935
1.22
1.16
4.2
3.6
1.6
2.0
mmol/l
0.58
96
743
115
964
1.21
1.15
2.1
2.3
0.2
0.2
g/l
0.34
106
910
5
20
2.51
1.15
1.6
1.6
—
—
—
0
0
267
2399
1.14
1.15
1.3
1.3
2.7
1.9
u/ml
0.23
71
667
23
150
1.54
1.15
1.1
1.4
22.2
25.1
u/l
0.20
18
127
79
637
1.26
1.13
3.1
2.6
—
—
—
0
0
55
424
1.31
1.12
1.1
1.1
—
—
—
0
0
179
1570
1.16
1.08
2.8
2.5
12.9
13.6
umol/l
0.53
174
1456
234
2093
1.14
1.08
1.6
1.7
35784773.8
27278299.2
pmol/l
0.09
204
1767
31
219
1.43
1.07
12.0
4.1
3.2
2.5
mmol/l
0.45
17
152
139
1196
1.18
1.06
1.6
1.3
—
—
—
0
0
49
375
1.32
1.06
5.2
3.5
0.2
0.2
g/l
0.00
19
162
14
82
1.71
1.05
1.1
1.1
—
—
—
0
0
154
1340
1.17
1.03
2.9
2.6
21.6
23.7
%
0.85
138
1155
7
34
2.06
1.03
1.0
1.1
—
—
—
0
0
46
352
1.32
1.00
1.2
1.3
149.7
239.0
miu/ml
1.37
23
160
7
35
2.01
1.00
1.1
1.5
—
—
—
0
0
1114
10906
1.15
0.99
19.5
15.3
139.6
139.7
mmol/l
0.82
1094
10633
11
61
1.81
0.98
1.1
1.2
—
—
—
0
0
182
1611
1.15
0.98
1.6
1.6
—
—
—
0
0
48
371
1.31
0.98
5.4
4.3
1.2
1.4
mmol/l
0.71
48
363
61
487
1.26
0.98
2.5
2.3
—
—
—
0
0
7
36
1.95
0.97
1.0
2.1
—
—
—
0
0
49
381
1.30
0.96
3.7
3.6
614.7
1099.9
u/ml
0.35
43
327
109
928
1.19
0.96
2.4
2.3
13.0
13.2
nmol/l
0.08
97
830
100
845
1.20
0.95
2.4
2.4
6.5
7.8
ug/l
0.31
85
762
151
1322
1.16
0.95
1.3
1.3
—
—
—
0
0
496
4666
1.10
0.95
10.7
9.3
0.0
0.0
e9/l
0.34
406
3839
16
101
1.59
0.93
1.3
1.3
—
—
—
0
0
314
2888
1.11
0.93
3.8
3.6
—
—
—
0
0
96
812
1.20
0.91
3.0
2.9
66.0
66.8
g/l
0.42
87
748
994
9685
1.11
0.88
5.0
4.6
1.8
2.0
mu/l
0.70
916
8929
14
87
1.62
0.87
2.5
2.0
—
2.0
—
0
7
42
325
1.30
0.87
8.6
10.0
—
—
—
0
0
86
724
1.20
0.87
1.2
1.2
74.0
147.8
iu/ml
2.33
29
286
39
299
1.31
0.86
3.2
3.8
33.7
31.6
mg/l
0.17
30
238
8
44
1.82
0.86
4.3
2.8
—
—
—
0
0
106
1228
0.85
0.86
1.5
1.3
—
—
—
0
0
35
265
1.33
0.85
10.9
3.9
7.4
7.4
ph
0.39
29
216
6
31
1.94
0.84
1.2
1.0
—
4.1
—
0
7
19
129
1.48
0.83
2.4
1.7
—
—
—
0
0
128
1121
1.16
0.82
1.4
1.4
—
—
—
0
0
14
89
1.58
0.81
2.2
2.2
572.1
745.9
e6/l
—
8
37
24
172
1.40
0.81
3.2
2.6
—
—
—
0
0
24
172
1.40
0.81
1.1
1.1
103.9
109.0
iu/ml
—
7
44
48
384
1.26
0.79
1.7
1.7
—
—
—
0
0
0
24
0.00
0.79
0.0
1.5
—
—
—
0
0
99
853
1.17
0.79
1.3
1.4
—
—
—
0
0
16
106
1.52
0.79
3.0
2.3
10.5
6.8
umol/l
0.42
11
75
54
439
1.24
0.78
2.0
1.7
—
—
—
0
0
25
182
1.38
0.78
1.3
1.4
—
—
—
0
0
1114
10943
1.12
0.78
19.6
15.4
4.0
4.0
mmol/l
0.14
1089
10651
20
140
1.44
0.77
4.2
3.0
—
—
—
0
0
6
34
1.77
0.76
1.3
1.2
—
—
—
0
0
31
235
1.33
0.76
1.4
1.5
—
—
—
0
0
14
91
1.54
0.75
1.1
1.3
85149.4
108262.7
e6/l
—
9
48
13
83
1.57
0.75
1.2
1.4
—
—
—
0
0
1046
10662
0.90
0.74
4.4
4.2
1.4
1.4
mmol/l
0.30
964
9915
17
116
1.47
0.74
1.1
1.1
—
—
—
0
0
19
133
1.43
0.73
2.7
2.8
—
—
—
0
0
7
38
1.85
0.73
4.6
3.1
—
—
—
0
0
1068
10872
0.90
0.73
4.8
4.7
2.8
2.8
mmol/l
0.20
979
10099
37
290
1.28
0.73
2.3
2.7
36.2
38.2
g/l
0.88
29
256
1010
10309
0.91
0.73
4.0
3.9
1.4
1.3
mmol/l
1.87
940
9553
38
299
1.28
0.73
3.2
3.8
48.9
72.0
mg/l
0.48
29
237
273
2942
0.91
0.72
1.4
1.4
—
—
—
0
0
11
68
1.62
0.71
1.0
1.1
8.6
6.7
iu/ml
—
5
16
195
1776
1.12
0.71
3.6
3.1
2.4
2.4
mmol/l
0.05
177
1574
14
93
1.51
0.69
1.2
1.4
—
—
—
0
0
264
2446
1.10
0.69
5.4
4.6
—
—
—
0
0
23
170
1.36
0.67
1.8
1.8
1.0
0.9
g/l
0.02
18
126
28
214
1.32
0.67
2.3
2.3
136.4
130.7
g/l
0.48
20
160
41
330
1.25
0.67
1.6
1.4
9.4
8.8
u/l
0.13
35
269
50
412
1.22
0.66
10.2
7.0
1.0
0.9
%
0.65
44
385
338
3179
1.09
0.64
3.6
3.2
7.8
7.9
mmol/l
0.08
279
2690
100
882
1.14
0.62
4.1
4.3
0.9
0.9
%
0.06
31
269
6
103
0.58
0.62
1.0
1.1
—
—
—
0
0
50
416
1.21
0.62
10.1
6.9
1.8
1.6
%
0.59
44
389
29
226
1.29
0.62
2.7
2.9
—
—
—
0
0
8
50
1.60
0.61
1.0
1.1
—
—
—
0
0
8
52
1.54
0.59
1.1
1.2
—
—
—
0
0
11
72
1.53
0.59
1.6
2.2
—
—
—
0
0
0
23
0.00
0.58
0.0
2.7
—
3820.8
—
0
23
7
115
0.61
0.58
1.3
1.1
—
—
—
0
0
26
202
1.29
0.57
3.4
2.4
17.9
16.4
%
0.74
12
105
982
10003
0.93
0.57
17.7
14.2
39.6
40.4
%
1.67
731
7497
8
55
1.46
0.56
39.3
33.8
6.2
7.4
ug/l
—
8
49
6
37
1.62
0.55
4.0
1.9
1.1
0.8
ug/l
—
6
32
6
37
1.62
0.55
1.2
1.3
2.0
3.7
%
—
6
28
38
460
0.82
0.55
1.8
1.9
—
—
—
0
0
18
133
1.36
0.55
2.1
2.5
—
—
—
0
0
1055
10711
0.92
0.55
4.4
4.3
4.7
4.7
mmol/l
0.38
980
10019
48
404
1.20
0.54
2.1
2.3
20.3
21.3
s
1.24
39
358
6
38
1.58
0.54
1.0
1.1
—
—
—
0
0
17
125
1.36
0.53
1.1
1.2
—
—
—
0
0
94
837
1.13
0.53
4.0
4.4
0.1
0.1
%
0.27
32
249
39
467
0.83
0.51
1.8
2.0
—
—
—
0
0
68
776
0.87
0.51
1.3
1.4
—
—
—
0
0
27
215
1.26
0.51
6.2
4.0
58.0
57.4
%
0.09
27
215
105
945
1.12
0.50
1.6
1.6
—
—
—
0
0
39
465
0.83
0.50
1.8
1.9
—
—
—
0
0
7
46
1.52
0.48
2.0
1.5
—
—
—
0
0
72
635
1.14
0.48
3.1
3.4
4.3
4.6
pmol/l
1.08
58
554
39
462
0.84
0.47
1.8
2.0
—
—
—
0
0
26
209
1.25
0.46
2.8
2.0
—
—
—
0
0
85
762
1.12
0.45
3.1
2.9
160.9
185.1
ng/l
0.24
71
693
7
51
1.37
0.44
2.6
1.6
—
—
—
0
0
46
397
1.16
0.42
1.8
1.6
281.9
288.2
mu/l
0.07
41
364
13
96
1.36
0.41
1.6
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
4.9
—
—
—
0
0
0
17
0.00
0.40
0.0
1.3
—
191.0
—
0
10
5
34
1.47
0.40
10.6
12.7
—
—
—
0
0
14
106
1.32
0.39
1.1
1.2
—
—
—
0
0
887
9020
0.95
0.39
19.7
16.2
13.7
13.6
%
1.06
876
8830
0
19
0.00
0.39
0.0
2.0
—
—
—
0
0
22
178
1.24
0.39
1.2
1.2
5.0
6.5
u/ml
—
8
71
70
630
1.12
0.37
3.2
3.1
126.7
129.9
g/l
0.57
70
617
80
879
0.90
0.36
4.7
3.8
—
—
—
0
0
12
90
1.34
0.36
1.2
1.4
—
—
—
0
0
25
209
1.20
0.34
5.7
3.6
4.2
4.3
e9/l
0.03
25
209
6
46
1.31
0.33
23.2
30.7
98.4
140.1
ug/l
—
6
36
10
74
1.35
0.32
2.3
1.4
—
—
—
0
0
38
433
0.87
0.32
1.8
2.0
—
—
—
0
0
12
92
1.31
0.32
4.3
3.6
—
—
—
0
0
21
174
1.21
0.31
3.3
3.1
0.8
0.9
nmol/l
0.52
15
136
87
803
1.09
0.30
3.8
4.2
0.5
0.6
%
0.36
22
201
51
458
1.12
0.30
3.1
3.3
—
—
—
0
0
26
222
1.17
0.29
3.1
4.1
—
—
—
0
0
302
2912
1.05
0.29
3.9
3.3
717.7
318.0
mg/l
0.54
199
1853
994
9831
1.05
0.28
5.7
5.4
39.7
39.5
mmol/mol
0.33
922
9165
74
682
1.09
0.27
1.2
1.2
—
—
—
0
0
40
358
1.12
0.25
1.2
1.2
—
—
—
0
0
1153
11453
1.06
0.25
12.4
10.1
28.1
27.7
u/l
0.20
1119
11103
728
7394
0.97
0.25
3.8
3.6
—
—
—
0
0
33
292
1.13
0.25
3.2
3.4
—
—
—
0
0
1197
12033
0.94
0.24
25.3
19.7
135.8
137.0
g/l
2.08
1184
11869
16
191
0.84
0.24
1.1
1.1
15.6
5.9
u/ml
0.54
11
99
1197
12032
0.94
0.24
25.2
19.6
6.9
6.7
e9/l
2.52
1174
11719
128
1214
1.06
0.23
1.6
1.7
—
—
—
0
0
1197
12030
0.94
0.23
25.1
19.6
4.5
4.5
e12/l
0.78
1171
11717
1196
12020
0.94
0.23
25.2
19.6
252.3
251.1
e9/l
0.25
1174
11737
1197
12029
0.94
0.22
25.0
19.5
30.2
30.3
pg
1.02
1183
11866
73
681
1.08
0.22
3.2
2.5
—
—
—
0
0
119
1130
1.06
0.21
1.5
1.4
—
—
—
0
0
1197
12027
0.94
0.21
25.0
19.5
90.7
90.8
fl
0.49
1183
11865
5
42
1.19
0.21
1.2
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
41
373
1.10
0.21
2.4
2.6
—
—
—
0
0
8
105
0.76
0.21
1.1
1.1
—
—
—
0
0
5
43
1.16
0.21
1.0
1.0
—
—
—
0
0
22
192
1.15
0.20
1.0
1.1
—
—
—
0
0
10
80
1.25
0.20
3.4
2.9
38.5
43.1
%
—
5
23
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
6
48
1.25
0.20
1.2
1.1
—
2.7
—
0
8
6
52
1.15
0.19
2.7
1.4
—
—
—
0
0
22
194
1.14
0.18
1.2
1.1
—
13.7
—
0
11
27
300
0.90
0.18
1.9
2.0
195.1
209.1
pmol/l
0.33
27
282
21
185
1.14
0.18
2.5
2.4
—
—
—
0
0
28
252
1.11
0.18
3.2
2.7
25.2
25.1
mmol/l
0.06
23
224
7
62
1.13
0.17
1.3
3.0
—
—
—
0
0
83
787
1.06
0.17
4.0
4.5
0.0
0.5
%
0.68
28
210
5
67
0.75
0.17
1.0
1.0
—
—
—
0
0
5
70
0.71
0.16
1.2
1.0
—
—
—
0
0
14
162
0.86
0.16
2.7
2.9
3.4
29.3
u/ml
0.55
14
154
16
183
0.87
0.16
1.1
1.1
2.8
0.8
u/ml
—
10
79
21
187
1.13
0.16
1.2
1.3
—
—
—
0
0
24
266
0.90
0.15
1.7
1.9
2.2
4.6
iu/l
—
9
96
49
524
0.93
0.15
1.0
1.1
—
—
—
0
0
10
119
0.84
0.15
2.4
2.4
33.8
32.5
pg
—
10
119
22
197
1.12
0.15
1.1
1.1
—
—
—
0
0
9
78
1.15
0.15
8.2
14.9
512.2
797.6
nmol/l
—
9
73
21
234
0.90
0.15
1.2
1.3
—
—
—
0
0
23
208
1.11
0.14
1.2
1.1
—
—
—
0
0
23
208
1.11
0.14
1.2
1.1
—
—
—
0
0
10
84
1.19
0.14
1.0
1.2
—
—
—
0
0
94
902
1.05
0.13
1.3
1.4
—
—
—
0
0
313
3073
1.02
0.13
4.4
4.1
17.9
9.0
mg/mmol
1.15
208
1939
1120
11245
0.97
0.12
16.2
12.6
—
—
—
0
0
18
162
1.11
0.12
1.1
1.7
—
—
—
0
0
18
199
0.90
0.11
1.4
1.5
—
—
—
0
0
60
628
0.95
0.11
1.7
1.6
—
—
—
0
0
24
260
0.92
0.11
2.5
2.4
35.7
126.3
ug/min
2.15
12
162
11
96
1.15
0.10
1.3
1.4
1.1
1.4
nmol/l
0.52
11
88
18
164
1.10
0.09
1.4
1.5
—
—
—
0
0
5
48
1.04
0.09
1.8
1.7
—
—
—
0
0
83
803
1.04
0.09
5.2
3.8
1.2
1.2
mmol/l
2.11
74
697
5
60
0.83
0.08
1.4
1.5
—
—
—
0
0
7
64
1.09
0.08
5.9
4.0
—
—
—
0
0
18
195
0.92
0.08
1.4
1.4
—
—
—
0
0
50
480
1.04
0.08
3.2
3.3
25.6
25.2
mmol/l
0.28
50
465
14
127
1.10
0.08
2.1
2.4
—
—
—
0
0
1030
10336
0.98
0.07
4.6
4.3
6.0
5.9
mmol/l
0.48
936
9492
278
2816
0.98
0.07
3.5
3.1
—
—
—
0
0
18
194
0.93
0.07
1.3
1.4
—
—
—
0
0
8
93
0.86
0.06
1.3
1.5
0.9
1.0
g/l
—
8
93
54
522
1.04
0.06
1.6
1.4
25.3
28.0
iu/l
0.25
47
450
13
119
1.09
0.06
1.9
2.4
—
—
—
0
0
18
169
1.07
0.05
1.2
1.2
—
—
—
0
0
35
363
0.96
0.04
1.8
1.8
—
—
—
0
0
16
150
1.07
0.04
1.4
1.5
0.4
0.3
nmol/l
0.19
11
123
34
328
1.04
0.04
1.3
1.2
—
—
—
0
0
16
170
0.94
0.04
1.4
1.2
—
—
—
0
0
29
301
0.96
0.03
3.3
2.6
—
—
—
0
0
20
210
0.95
0.03
1.2
1.1
0.2
2.1
u/ml
2.18
11
89
21
220
0.95
0.03
6.2
3.6
24.2
24.9
mg/l
0.03
14
137
19
199
0.95
0.03
1.3
1.2
—
—
—
0
0
21
219
0.96
0.03
2.9
2.9
1.6
1.5
mmol/l
0.18
21
213
16
152
1.05
0.02
1.3
1.3
—
0.4
—
0
13
351
3496
1.01
0.02
5.1
4.5
2.1
2.2
ug/l
0.18
315
3159
26
268
0.97
0.02
1.8
1.7
—
—
—
0
0
15
143
1.05
0.01
1.1
1.1
1.9
3.5
u/ml
—
6
53
16
153
1.05
0.01
1.1
1.0
5.9
2.5
u/ml
—
8
55
22
227
0.97
0.01
1.2
1.2
240.1
265.3
u/ml
0.22
15
140
11
104
1.06
0.01
3.3
2.2
—
—
—
0
0
23
236
0.97
0.00
1.1
1.3
—
—
—
0
0
14
142
0.99
0.00
1.3
1.3
—
—
—
0
0
15
152
0.99
0.00
1.3
1.3
0.5
0.6
nmol/l
0.57
15
145
16
162
0.99
0.00
1.1
1.2
—
—
—
0
0
19
188
1.01
0.00
7.7
3.0
—
—
—
0
0
24
242
0.99
0.00
2.8
4.2
—
—
—
0
0
283
2832
1.00
0.00
1.6
1.7
1.6
1.4
mmol/l
0.58
241
2393
18
183
0.98
0.00
1.2
1.4
—
—
—
0
0
206
2055
1.00
0.00
2.9
2.8
0.6
0.7
ug/l
2.08
132
1243
21
215
0.98
0.00
2.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
62
0.97
0.00
2.3
1.5
—
—
—
0
0
14
140
1.00
0.00
1.1
1.3
—
—
nmol/l
—
0
0
6
64
0.94
0.00
1.0
1.5
5.1
7.5
u/l
—
6
51
5
55
0.91
0.00
1.0
1.1
110.2
227.2
iu/ml
—
5
55
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
3.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
12
120
1.00
0.00
1.1
1.4
—
—
—
0
0
5
55
0.91
0.00
3.0
3.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
12.6
—
0
8
9
92
0.98
0.00
1.7
1.8
11.2
10.9
%
—
9
92
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
6
61
0.98
0.00
3.3
7.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
7
73
0.96
0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
35.4
—
0
7
6
68
0.88
0.00
1.3
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint G6_MENINGBACT and mortality.

Females

Parameter HR [95% CI] p-value
G6_MENINGBACT 2.439 [2.05, 2.9] < 0.001
Birth year 0.996 [0.99, 1.0] 0.339

During the follow-up period (1.1.1998 — 31.12.2019), 366 out of 1921 females with G6_MENINGBACT died.

Males

Parameter HR [95% CI] p-value
G6_MENINGBACT 2.511 [2.12, 2.98] < 0.001
Birth year 0.987 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 528 out of 2305 males with G6_MENINGBACT died.

Mortality risk

Mortality risk for people of age

years, who have G6_MENINGBACT.

N-year risk Females Males
1 0.233% 0.462%
5 1.41% 3.008%
10 3.352% 7.395%
15 6.994% 13.678%
20 12.009% 22.485%

Relationships between endpoints

Index endpoint: G6_MENINGBACT – Bacterial meningitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data