bacterial meningitis: Inflammation of the membranes surrounding the brain and spinal cord due to a bacterial infection.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1336 |
4. Check minimum number of eventsNone |
1336 |
5. Include endpointsNone |
1336 |
6. Filter based on genotype QC (FinnGen only) |
1299 |
Control definitions (FinnGen only)
- Control exclude
- G6_NEUINFL
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Bacterial meningitis
based on the number of shared cases.
Similar with more cases:
- Meningitis
- Inflammatory diseases of the central nervous system
- Neurological diseases
- Neurological diseases, wide definition
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13164 | 5855 | 7210 |
| Only index persons | 10528 | 4917 | 5611 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.19 | 0.17 | 0.20 |
| Only index persons | 0.20 | 0.18 | 0.21 |
| Median age at first event (years) | |||
| Whole population | 26.64 | 28.04 | 25.10 |
| Only index persons | 22.93 | 25.96 | 20.28 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1299 | 685 | 614 |
| Unadjusted period prevalence (%) | 0.26 | 0.24 | 0.28 |
| Median age at first event (years) | 28.58 | 27.87 | 29.38 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1336
- Matched controls
- 13360
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
32099
ICD-8 Finland
Meningitis, With no organism specified as cause
+∞
307.7
370
*
G00.9
ICD-10 Finland
Bacterial meningitis, unspecified
3360.2
302.8
281
*
32088
ICD-8 Finland
Meningitis, Alia definita
+∞
214.5
200
*
TAB00
NOMESCO Finland
Lumbar puncture
7.7
121.5
184
272
32000
ICD-8 Finland
Meningitis, H. influenzae
+∞
119.6
113
*
G01*A69.2
ICD-10 Finland
Meningitis (in) Lyme disease
+∞
113.2
107
*
G00.1
ICD-10 Finland
Pneumococcal meningitis
+∞
99.2
94
*
A87.9
ICD-10 Finland
Viral meningitis, unspecified
26.8
85.4
59
23
G03.9
ICD-10 Finland
Meningitis, unspecified
+∞
75.8
72
*
A40.3
ICD-10 Finland
Sepsis due to Streptococcus pneumoniae
19.8
59.1
46
24
AAF00
NOMESCO Finland
Ventriculostomy
20.1
53.0
41
21
G01*A39.0
ICD-10 Finland
Meningococcal meningitis
+∞
44.0
42
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.2
37.9
164
558
G00.8
ICD-10 Finland
Other bacterial meningitis
+∞
35.6
34
*
AA1AD
NOMESCO Finland
CT of head and brain
2.2
35.0
399
2168
G00.3
ICD-10 Finland
Staphylococcal meningitis
+∞
33.5
32
*
G00.2
ICD-10 Finland
Streptococcal meningitis
+∞
32.4
31
*
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
9.3
30.5
37
41
R51.80
ICD-10 Finland
Headache
2.3
28.4
256
1251
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.3
26.8
246
1210
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
4.3
26.0
69
168
G01*A32.1
ICD-10 Finland
Listerial meningitis
+∞
25.1
24
*
3209X
ICD-9 Finland
Bacterial meningitis, Meningitis due to unspecified bacterium
+∞
25.1
24
*
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
55.0
23.1
27
5
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.3
23.1
92
296
G04.9
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis, unspecified
+∞
21.9
21
*
A69.2
ICD-10 Finland
Lyme disease
2.9
21.5
104
375
N03AX14
ATC
levetiracetam; systemic
4.3
21.4
56
135
32010
ICD-8 Finland
Meningitis, Pneumococcus
+∞
20.9
20
*
G51.0
ICD-10 Finland
Bell palsy
4.4
20.8
53
125
G01
ICD-10 Finland
Meningitis in bacterial diseases classified elsewhere
+∞
19.8
19
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.1
19.2
221
1176
G00.0
ICD-10 Finland
Haemophilus meningitis
+∞
18.8
18
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
3.5
18.1
62
181
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
6.1
17.4
30
50
R50.9
ICD-10 Finland
Fever, unspecified
2.0
17.0
215
1180
R51
ICD-10 Finland
Headache
2.7
16.6
90
345
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
4.5
16.2
39
88
3201A
ICD-9 Finland
Bacterial meningitis, Pneumococcal meningitis
+∞
15.7
15
*
3200A
ICD-9 Finland
Bacterial meningitis, Haemophilus meningitis
+∞
15.7
15
*
A86
ICD-10 Finland
Unspecified viral encephalitis
20.3
15.1
22
11
A39.0
ICD-10 Finland
Meningococcal meningitis
+∞
14.6
14
*
XA800
NOMESCO Finland
Neuropsychological investigation
2.8
14.2
71
261
04599
ICD-8 Finland
Aseptic mentingitis due to enterovirus, Aseptic meningitis, unspecified
34.4
13.5
17
5
G96.0
ICD-10 Finland
Cerebrospinal fluid leak
34.4
13.5
17
5
G91.0
ICD-10 Finland
Communicating hydrocephalus
10.2
13.0
25
25
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
3.9
12.9
38
100
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.1
12.8
121
595
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
14.2
12.8
21
15
X59
ICD-10 Finland
Exposure to unspecified factor
1.7
12.7
255
1606
N03AF01
ATC
carbamazepine; oral, rectal
2.5
12.6
77
313
N03AX16
ATC
[U] pregabalin
1.7
12.5
300
1981
N03AG01
ATC
valproic acid; systemic, rectal
2.3
12.4
94
423
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
12.3
292
1922
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.1
12.3
127
646
N03AX12
ATC
[U] gabapentin; oral
1.8
12.2
218
1327
AAF99
NOMESCO Finland
Other shunt operation on ventricle of brain or intracerebral cyst
37.9
12.2
15
*
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
5.6
12.1
23
42
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
5.7
12.0
22
39
N03AB02
ATC
phenytoin; systemic
4.9
11.9
26
54
J01FF01
ATC
clindamycin; systemic
1.6
11.8
349
2423
N03AF02
ATC
oxcarbazepine; oral
3.0
11.3
51
177
N05CF01
ATC
zopiclone; oral
1.5
11.1
393
2840
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
4.0
11.1
31
79
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.7
10.9
58
220
WX730
NOMESCO Finland
Conventional respirator
4.6
10.7
25
55
XF400
NOMESCO Finland
ECG with 12 standard connections
1.7
10.7
194
1184
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
10.7
272
1816
N71
ICPC
Meningitis/encephalitis
110.9
10.4
11
*
N02AX02
ATC
tramadol; systemic, rectal
1.5
10.4
533
4147
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
13.2
10.2
17
13
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.0
10.1
111
577
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
10.1
441
3318
WX882
NOMESCO Finland
High dependency care
3.1
10.0
41
135
AA1BD
NOMESCO Finland
Extensive CT of head and brain
3.2
9.8
39
126
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
4.9
9.8
21
43
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.5
9.8
59
239
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
9.8
548
4321
R42
ICD-10 Finland
Dizziness and giddiness
1.6
9.6
261
1768
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
9.5
282
1948
H66.0
ICD-10 Finland
Acute suppurative otitis media
2.0
9.5
98
499
G44.2
ICD-10 Finland
Tension-type headache
1.7
9.5
173
1058
A32.7
ICD-10 Finland
Listerial sepsis
100.7
9.4
10
*
G01*A17.0
ICD-10 Finland
Tuberculous meningitis
+∞
9.4
9
*
XCK00
NOMESCO Finland
Perimetry
2.2
9.2
73
335
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
3.4
9.1
32
96
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.4
9.0
62
267
AWB00
NOMESCO Finland
Reoperation for superficial infection in surgery of the nervous system
36.9
9.0
11
*
AAK00
NOMESCO Finland
Cranioplasty
36.9
9.0
11
*
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
4.0
8.9
25
64
G91.1
ICD-10 Finland
Obstructive hydrocephalus
10.8
8.8
16
15
A41.9
ICD-10 Finland
Sepsis, unspecified
2.6
8.6
48
187
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
8.6
225
1506
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
8.6
649
5363
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.8
8.5
130
754
TAA40
NOMESCO Finland
Cathetrisation of cerebrospinal fluid through skin
27.7
8.5
11
*
N73
ICPC
Neurological infection other
90.6
8.4
9
*
N06AA09
ATC
amitriptyline; systemic
1.8
8.3
117
661
AAE05
NOMESCO Finland
Nasoendoscopic closure of cerebrospinal fluid fistula
+∞
8.3
8
*
G06.0
ICD-10 Finland
Intracranial abscess and granuloma
+∞
8.3
8
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.1
8.3
79
390
H02AB06
ATC
prednisolone; systemic
1.4
8.3
571
4634
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.2
8.3
71
337
J01DB01
ATC
cefalexin; oral
1.5
8.0
1052
9528
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.0
7.9
86
446
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
3.6
7.9
25
70
J01AA02
ATC
doxycycline; systemic
1.4
7.9
970
8661
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.5
7.8
48
197
H02AB07
ATC
prednisone; oral
1.7
7.8
160
1009
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
4.4
7.7
19
44
ZXD05
NOMESCO Finland
Urgent procedure
1.4
7.7
367
2784
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
3.0
7.6
32
107
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.8
7.6
126
748
AAK40
NOMESCO Finland
Closure of cerebrospinal fluid fistula
18.5
7.6
11
6
SPAT1255
SPAT
Intravenous administration of medicine
2.0
7.6
83
432
A02BC02
ATC
pantoprazole; systemic
1.4
7.5
825
7185
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.6
7.5
186
1228
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
7.4
308
2271
79199
ICD-8 Finland
Headache
3.9
7.4
21
54
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
2.4
7.4
51
221
J01DA01
ATC
[U] cefalexin
1.4
7.4
756
6503
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.4
7.4
330
2470
A32.1
ICD-10 Finland
Listerial meningitis and meningoencephalitis
+∞
7.3
7
*
3202A
ICD-9 Finland
Bacterial meningitis, Streptococcal meningitis
+∞
7.3
7
*
G02.0*B00.3
ICD-10 Finland
Herpesviral meningitis
+∞
7.3
7
*
B94.80
ICD-10 Finland
Late effects of bacterial meningitis
+∞
7.3
7
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
1.9
7.3
85
453
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.6
7.2
162
1046
N03AE01
ATC
clonazepam; systemic
2.1
7.1
69
344
TKC20
NOMESCO Finland
Catheterisation of bladder
2.0
7.0
75
387
U07
ICPC
Urine symptom/complaint other
1.9
6.9
79
418
J13
ICD-10 Finland
Pneumonia due to Streptococcus pneumoniae
4.1
6.8
18
44
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
4.1
6.8
18
44
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.7
6.8
136
851
A02BC01
ATC
omeprazole; systemic
1.4
6.8
301
2245
J02AC01
ATC
fluconazole; systemic
1.4
6.7
445
3557
AAL00
NOMESCO Finland
Endovascular occlusion of intracranial aneurysm
22.6
6.7
9
*
ZXC95
NOMESCO Finland
Use of surgical navigator
3.7
6.6
20
54
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
3.1
6.6
27
89
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
1.9
6.6
84
461
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.4
6.5
280
2075
ZXA00
NOMESCO Finland
Right side
1.4
6.4
295
2212
G50.0
ICD-10 Finland
Trigeminal neuralgia
2.9
6.3
28
97
N03AX18
ATC
lacosamide; systemic
6.0
6.3
16
27
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
18.1
6.3
9
5
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
2.2
6.3
51
238
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
2.7
6.3
33
126
ABD40
NOMESCO Finland
Implantation of spinal injection device
+∞
6.3
6
*
AWC00
NOMESCO Finland
Reoperation of nervous system because of deep wound infection in the nervous system
+∞
6.3
6
*
78559
ICD-8 Finland
Symptoms referable to abdomen and lower gastro-intestinal tract, Colica abdominalis NUD
2.4
6.2
39
162
N03AX09
ATC
lamotrigine; oral
2.1
6.2
60
299
ZXE10
NOMESCO Finland
More than one and less than three hours
1.4
6.2
411
3275
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.3
6.2
537
4459
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
4.0
6.2
17
43
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
2.0
6.2
63
321
G40.10
ICD-10 Finland
Simple partial seizures
5.8
6.1
16
28
J05AB01
ATC
aciclovir; systemic
1.5
6.1
247
1806
0499X
ICD-9 Finland
Other non-arthropod-borne viral diseases of central nervous system, Unspecified non-arthropod-borne viral diseases of central nervous system
12.6
6.1
10
8
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
125
103
13.29
127.54
2.3
1.7
—
—
—
0
0
176
279
7.11
108.67
2.0
1.2
1370.61
490.10
mg/l
10.49
170
260
162
246
7.36
103.96
1.8
1.2
3.11
3.74
mmol/l
5.27
148
232
80
50
16.96
94.83
2.0
2.1
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
77
59
13.79
81.60
1.2
1.1
—
—
—
0
0
140
246
6.24
77.58
2.0
1.4
501.07
8.26
e6/l
2.74
113
189
140
246
6.24
77.58
2.1
1.5
767.94
907.16
e6/l
0.08
115
196
73
56
13.73
77.26
1.2
1.0
—
—
—
0
0
58
42
14.39
63.32
1.2
1.2
—
—
—
0
0
74
105
7.40
49.94
1.1
1.0
—
—
—
0
0
38
22
17.75
46.41
1.1
1.0
—
—
—
0
0
72
118
6.39
42.44
1.3
1.0
72.55
—
au/ml
—
10
0
36
31
11.91
35.27
1.2
1.0
—
—
—
0
0
35
30
11.95
34.38
1.2
1.0
—
—
—
0
0
38
37
10.54
34.34
1.5
1.1
—
—
—
0
0
33
32
10.55
29.87
1.2
1.0
—
—
—
0
0
35
41
8.74
27.60
1.1
1.0
—
—
—
0
0
30
30
10.21
26.56
1.2
1.0
—
—
—
0
0
61
134
4.72
26.11
4.8
6.0
10.61
11.09
mg/l
0.32
56
121
42
67
6.44
25.36
1.2
1.1
—
—
—
0
0
168
764
2.37
21.71
2.9
2.4
30.48
23.90
au/ml
—
10
61
152
694
2.34
19.40
1.6
1.3
66.09
42.72
au/ml
0.72
14
39
49
119
4.24
18.52
1.6
1.7
—
—
—
0
0
24
31
7.87
17.45
1.2
1.0
—
—
—
0
0
29
47
6.28
17.24
2.6
1.1
34.12
65.60
%
—
17
5
21
12
17.76
13.85
1.1
1.1
—
—
—
0
0
23
19
12.30
13.12
1.1
1.2
—
—
—
0
0
686
5548
1.49
11.27
6.8
6.5
10.01
11.43
umol/l
4.11
647
5294
37
108
3.50
10.89
1.8
1.8
—
—
—
0
0
17
11
15.63
10.84
1.0
1.1
—
—
—
0
0
15
7
21.65
10.69
1.0
1.1
—
—
—
0
0
18
14
13.01
10.66
1.1
1.1
—
—
—
0
0
246
1609
1.65
10.51
1.9
1.9
—
—
—
0
0
43
142
3.10
10.41
1.2
1.1
—
—
—
0
0
581
4652
1.44
9.47
6.9
6.4
1.20
1.21
mmol/l
2.20
531
4258
147
861
1.79
9.33
3.6
2.7
10.43
10.61
g/l
0.18
140
795
738
6192
1.43
9.19
5.8
5.0
6.68
6.67
mmol/l
0.04
694
5812
416
3145
1.47
9.10
2.4
2.1
148.17
248.48
u/l
2.37
397
2963
237
1591
1.60
9.01
2.0
2.2
29.68
29.80
s
0.08
231
1538
16
16
10.11
8.53
1.3
1.0
—
—
—
0
0
625
5143
1.40
8.40
7.9
7.0
1.21
1.21
mmol/l
0.63
529
4386
16
17
9.51
8.28
1.3
1.0
—
—
—
0
0
15
15
10.10
8.03
1.0
1.0
—
—
—
0
0
634
5273
1.39
7.79
7.7
6.2
28.65
28.11
%
0.54
598
4973
583
4788
1.39
7.71
15.5
13.5
1.24
1.22
inr
0.20
174
1410
428
3341
1.41
7.61
2.7
2.6
62.12
82.81
u/l
0.37
393
3122
48
202
2.43
7.41
1.8
1.5
—
—
—
0
0
542
4422
1.38
7.36
5.8
5.1
35.37
35.88
g/l
1.18
508
4151
27
85
3.22
7.14
1.0
1.0
—
—
—
0
0
729
6264
1.36
7.01
10.7
9.3
4.21
4.06
e9/l
1.00
652
5510
621
5206
1.36
6.99
7.4
5.9
56.42
57.00
%
0.55
585
4910
238
1692
1.49
6.87
3.4
3.7
0.83
0.82
mmol/l
0.24
226
1603
61
295
2.12
6.82
1.2
1.1
—
—
—
0
0
893
7965
1.37
6.50
4.9
4.0
12.04
11.31
mm/h
0.86
845
7412
69
358
1.98
6.40
2.0
1.7
—
—
—
0
0
62
310
2.05
6.37
1.6
1.7
—
—
—
0
0
73
388
1.93
6.32
2.1
1.8
—
—
—
0
0
30
110
2.77
6.14
1.4
1.4
280.70
282.57
mosm/kgh2o
0.16
23
87
64
329
1.99
6.11
2.7
2.8
—
—
—
0
0
919
8271
1.36
6.07
9.2
7.6
77.65
77.41
u/l
0.07
879
7829
347
2702
1.38
6.03
4.2
4.0
93.26
91.55
%
0.66
342
2635
478
3971
1.32
5.30
3.6
3.4
23.33
50.88
ng/l
2.03
327
2646
9
8
11.32
5.29
1.0
1.0
—
—
—
0
0
47
228
2.10
5.28
5.9
6.5
238.44
446.58
iu/ml
—
9
36
163
1131
1.50
5.26
1.8
1.8
—
—
—
0
0
28
108
2.63
5.24
1.9
8.5
7.86
7.26
mmol/l
0.13
18
89
164
1141
1.50
5.22
1.8
1.8
—
—
—
0
0
168
1175
1.49
5.21
9.4
9.2
1.01
1.17
mmol/l
0.24
140
935
91
559
1.67
4.93
1.5
1.6
—
—
—
0
0
13
24
5.46
4.92
1.0
1.0
15.17
7.35
mg/g
1.44
13
24
152
1055
1.50
4.90
9.8
9.7
95.70
95.77
%
0.04
145
1017
115
753
1.58
4.83
2.0
1.6
—
—
—
0
0
8
7
11.49
4.78
1.0
1.0
—
—
—
0
0
16
48
3.36
4.61
1.2
1.1
1823.00
1606.56
miu/ml
0.28
16
48
766
6847
1.28
4.60
5.7
4.1
791.71
2375.43
e6/l
0.69
14
100
135
929
1.50
4.54
7.7
8.1
8.23
9.15
mmol/l
0.96
130
883
8
8
10.05
4.52
1.0
1.0
—
—
—
0
0
164
1178
1.45
4.45
9.6
9.1
13.06
12.28
kpa
1.06
156
1135
164
1178
1.45
4.45
9.7
9.2
5.04
5.11
kpa
0.44
156
1132
20
71
2.84
4.40
1.0
1.1
1.18
1.07
u/l
—
8
39
159
1138
1.45
4.40
4.0
4.4
234.17
250.87
u/l
0.85
150
1081
68
406
1.71
4.13
2.7
2.1
1.40
2.00
ug/l
0.31
59
365
186
1387
1.40
4.10
6.3
6.1
1.02
1.03
mmol/l
0.37
176
1285
16
52
3.10
4.09
2.1
3.0
1047.63
1104.58
u/ml
0.06
16
52
139
988
1.45
3.99
10.7
10.0
118.08
122.30
g/l
1.53
133
963
57
327
1.78
3.99
2.3
1.6
0.22
0.24
g/l
0.68
52
312
27
118
2.31
3.96
1.2
1.3
—
—
—
0
0
479
4112
1.26
3.81
2.0
1.9
96.07
95.57
pmol/l
0.07
245
2168
139
999
1.44
3.77
2.5
2.5
33.75
82.83
u/l
0.52
122
859
7
8
8.79
3.77
1.0
1.1
—
—
—
0
0
272
2180
1.31
3.73
1.6
1.5
2.46
2.42
g/l
0.09
165
1373
61
365
1.70
3.71
2.4
2.2
316.93
512.95
ug/l
0.52
55
345
8
13
6.18
3.50
1.1
1.1
—
—
—
0
0
69
434
1.62
3.49
1.3
1.2
0.26
1.21
u/ml
—
8
27
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
55
326
1.72
3.48
2.6
3.1
0.29
0.37
u/ml
1.31
31
179
36
187
1.95
3.45
1.5
1.6
—
—
—
0
0
220
1732
1.32
3.42
3.1
2.6
1.01
1.14
e6/l
0.25
122
972
96
656
1.50
3.39
10.6
8.3
24.77
24.41
mmol/l
0.44
89
624
8
14
5.74
3.34
1.3
1.1
—
—
—
0
0
56
340
1.68
3.26
2.4
1.6
1.21
1.19
g/l
0.17
51
323
192
1495
1.33
3.22
1.7
1.9
1.45
1.46
%
0.08
169
1319
146
1092
1.38
3.18
2.7
2.8
1.82
1.82
%
0.02
130
978
825
7600
1.22
3.17
3.7
3.2
50.96
49.70
u/l
0.16
781
7161
35
186
1.91
3.17
2.1
1.8
—
—
—
0
0
52
313
1.69
3.14
1.4
1.2
48.40
15.07
u/ml
—
6
13
244
1976
1.29
3.08
3.5
3.7
233.74
466.67
ng/l
1.23
174
1478
305
2539
1.26
3.07
2.4
2.1
3.04
3.01
mg/l
0.06
262
2169
50
302
1.68
2.99
1.3
1.3
—
—
—
0
0
16
63
2.56
2.96
1.1
1.0
227.10
286.47
ng/l
—
10
38
49
296
1.68
2.93
1.5
1.2
1.58
8.58
u/ml
—
9
48
44
259
1.72
2.89
2.0
1.8
—
—
—
0
0
16
64
2.52
2.87
1.1
1.0
716.45
650.54
ng/l
0.25
11
39
16
64
2.52
2.87
1.1
1.0
38.50
44.55
ng/l
—
8
36
7
13
5.41
2.87
2.7
1.3
—
—
—
0
0
7
13
5.41
2.87
1.1
1.1
—
—
—
0
0
261
2150
1.27
2.86
3.3
2.5
4.66
5.61
e6/l
0.88
241
1947
43
253
1.72
2.84
2.0
1.8
—
—
—
0
0
493
4355
1.21
2.80
2.5
2.3
77.21
76.07
nmol/l
0.39
435
3928
33
180
1.85
2.79
1.8
1.7
—
—
—
0
0
33
180
1.85
2.79
1.8
1.7
—
—
—
0
0
15
59
2.56
2.79
1.0
1.2
—
—
—
0
0
66
436
1.54
2.77
1.5
2.1
1.77
1.52
g/l
1.18
57
380
333
2838
1.23
2.69
3.9
3.0
0.29
0.44
e6/l
0.93
257
2144
222
1809
1.27
2.66
2.0
1.7
1105.88
1183.56
nmol/l
0.72
168
1374
11
35
3.16
2.64
1.9
2.9
—
—
—
0
0
11
35
3.16
2.64
1.9
2.9
—
—
—
0
0
273
2282
1.25
2.63
4.7
3.7
1.02
1.02
kg/l
0.39
48
319
30
162
1.87
2.63
1.6
1.6
—
—
—
0
0
134
1022
1.35
2.61
2.4
2.1
351.51
370.26
nmol/l
0.38
122
950
362
3121
1.22
2.61
4.2
3.1
31.10
75.80
e6/l
1.28
284
2400
7
15
4.69
2.60
1.1
3.3
—
—
—
0
0
328
2801
1.23
2.59
2.9
2.7
1931.81
5485.12
umol/l
1.29
287
2483
47
292
1.63
2.57
1.4
1.2
5.97
2.75
u/ml
—
7
29
34
193
1.78
2.56
2.9
4.3
152.96
1895.88
u/ml
0.75
29
184
416
3656
1.20
2.44
3.7
3.4
33.65
32.33
u/l
0.28
395
3484
40
242
1.67
2.43
1.4
1.4
—
—
—
0
0
170
1359
1.29
2.38
2.7
2.4
157.71
124.41
ug/g
0.68
134
1104
300
2564
1.22
2.34
2.7
2.3
—
—
—
0
0
49
317
1.57
2.30
1.4
1.4
257.65
285.32
ug/g
0.48
32
185
43
270
1.61
2.28
1.3
1.2
—
—
—
0
0
882
8298
1.19
2.27
4.2
3.9
14.60
14.72
pmol/l
0.77
806
7614
39
242
1.63
2.18
2.1
1.6
—
—
—
0
0
513
4629
1.18
2.17
2.9
2.8
116.41
128.93
ug/l
0.72
474
4304
17
81
2.11
2.13
1.1
1.5
—
—
—
0
0
553
5030
1.17
2.10
2.8
2.5
—
—
—
0
0
53
357
1.50
2.10
1.8
1.7
—
—
—
0
0
288
2479
1.21
2.08
1.6
1.7
1.03
1.11
mg/l
0.29
218
1883
1136
10969
1.24
2.08
19.1
13.5
23.03
23.36
mg/l
0.12
943
8626
90
674
1.36
2.02
4.4
3.5
5.23
5.15
kpa
0.42
84
652
568
5190
1.16
2.02
4.2
3.5
0.00
0.00
estimate
0.50
99
1031
10
38
2.64
2.00
1.5
1.2
—
—
—
0
0
84
623
1.37
2.00
1.6
1.4
—
—
—
0
0
38
240
1.60
2.00
1.4
1.2
21.13
49.74
u/ml
—
9
19
154
1246
1.27
1.98
2.6
2.8
5.46
8.36
umol/l
3.64
128
1086
197
1640
1.24
1.98
3.6
2.8
2.26
2.42
e6/l
0.12
98
881
25
141
1.79
1.97
1.7
1.6
—
—
—
0
0
44
290
1.53
1.94
1.3
1.4
—
—
—
0
0
24
135
1.79
1.92
1.5
1.4
—
—
—
0
0
157
1279
1.26
1.92
4.8
4.3
32.51
31.62
%
0.37
102
886
23
128
1.81
1.90
1.5
1.7
—
—
—
0
0
23
128
1.81
1.90
1.5
1.7
—
—
—
0
0
39
253
1.56
1.85
1.7
1.7
9470.24
13335.55
e6/l
0.43
34
192
128
1022
1.28
1.85
4.1
4.5
13.11
22.59
ug/l
0.34
98
841
120
951
1.29
1.84
4.1
3.6
1.59
1.99
mmol/l
0.68
108
776
216
1832
1.21
1.82
1.4
1.3
5.08
12.91
u/ml
1.75
79
726
85
643
1.34
1.81
4.6
3.5
1.61
1.71
mmol/l
0.10
66
481
21
116
1.82
1.79
2.0
2.3
22.46
21.91
mg/l
—
5
29
32
200
1.61
1.78
1.3
1.3
—
—
—
0
0
32
200
1.61
1.78
1.3
1.3
—
—
—
0
0
224
1911
1.21
1.78
1.4
1.3
18.04
31.30
iu/ml
2.61
72
626
5
13
3.86
1.71
1.4
1.0
—
—
—
0
0
23
133
1.74
1.70
1.6
1.4
—
—
—
0
0
23
133
1.74
1.70
1.6
1.4
—
—
—
0
0
23
133
1.74
1.70
1.6
1.4
—
—
—
0
0
268
2335
1.18
1.69
1.6
1.5
21.52
20.99
nmol/l
0.20
231
2004
313
2763
1.17
1.69
4.7
3.8
0.00
0.01
estimate
1.08
89
953
387
3474
1.16
1.69
4.0
3.5
2.35
2.35
mmol/l
0.10
342
3102
12
55
2.19
1.67
1.3
1.3
—
—
—
0
0
12
55
2.19
1.67
1.3
1.3
—
—
—
0
0
776
7316
1.14
1.67
3.1
3.1
—
—
—
0
0
23
134
1.73
1.66
1.6
1.4
—
—
—
0
0
32
204
1.58
1.66
1.8
1.9
5.18
5.17
mmol/24h
0.01
23
182
6
19
3.17
1.66
1.5
1.4
—
—
—
0
0
91
706
1.31
1.65
1.3
1.3
111.06
212.29
u/ml
1.68
85
653
317
2806
1.17
1.65
2.9
3.0
1333.74
1170.36
ng/l
0.13
272
2375
38
253
1.52
1.64
2.3
1.7
—
—
—
0
0
49
344
1.44
1.64
2.1
2.3
1534.79
3296.76
u/l
0.73
16
139
23
135
1.72
1.63
1.6
1.4
—
—
—
0
0
10
43
2.34
1.59
2.2
1.8
—
—
—
0
0
10
43
2.34
1.59
2.2
1.8
—
—
—
0
0
17
92
1.86
1.56
1.9
1.6
—
—
—
0
0
17
92
1.86
1.56
1.9
1.6
—
—
—
0
0
17
92
1.86
1.56
1.9
1.6
—
—
—
0
0
566
5242
1.14
1.56
4.2
3.5
0.00
0.01
estimate
0.80
96
943
10
44
2.28
1.55
2.3
1.8
—
—
—
0
0
98
777
1.28
1.53
3.7
3.9
76.32
85.44
ng/l
0.72
87
688
24
146
1.66
1.51
1.6
1.6
—
—
—
0
0
6
21
2.87
1.50
2.0
2.2
22.98
16.94
umol/l
—
6
21
441
4026
1.14
1.50
4.4
3.6
—
—
—
0
0
10
45
2.23
1.46
2.1
2.5
—
—
—
0
0
559
5190
1.13
1.46
5.6
4.7
0.00
0.00
estimate
0.50
100
986
9
39
2.32
1.43
2.7
5.1
—
—
—
0
0
148
1242
1.22
1.42
8.0
6.8
—
—
—
0
0
33
221
1.51
1.42
1.5
1.5
—
—
—
0
0
49
355
1.39
1.41
1.7
1.8
—
—
—
0
0
11
53
2.08
1.38
2.2
1.7
—
—
—
0
0
11
53
2.08
1.38
2.2
1.7
—
—
—
0
0
35
239
1.48
1.38
12.7
9.9
103.52
105.60
mmol/l
1.32
29
216
277
2461
1.16
1.38
1.3
1.3
2.70
1.90
u/ml
0.23
72
679
119
984
1.23
1.33
2.1
2.3
0.22
0.22
g/l
0.25
110
929
45
326
1.39
1.31
3.9
3.0
1.73
0.89
g/l
0.40
37
291
20
122
1.65
1.27
2.1
1.9
—
—
—
0
0
242
2143
1.16
1.26
1.6
1.7
34434417.68
26674471.07
pmol/l
0.08
212
1807
102
835
1.24
1.26
2.9
2.9
66.25
66.83
g/l
0.27
92
769
172
1484
1.18
1.24
2.8
2.5
2.33
2.35
g/l
0.11
167
1385
16
93
1.73
1.21
1.2
1.3
76824.50
104066.68
e6/l
—
10
50
20
124
1.62
1.21
1.4
1.6
52.87
57.01
%
0.15
15
91
24
156
1.55
1.20
1.8
1.8
—
—
—
0
0
8
39
2.06
1.15
1.8
2.4
—
—
—
0
0
52
396
1.33
1.14
4.0
3.6
576.09
3558.51
u/ml
0.62
46
340
97
1168
0.82
1.13
1.8
1.7
—
—
—
0
0
7
30
2.34
1.12
1.4
1.0
—
—
—
0
0
184
1613
1.16
1.11
2.8
2.5
12.81
13.68
umol/l
0.68
179
1507
1066
10377
1.13
1.09
15.1
12.2
84.84
83.61
ml/min/173m2
1.09
911
8558
5
21
2.39
1.09
1.0
1.3
—
—
—
0
0
32
227
1.42
1.08
11.6
4.1
3.17
2.48
mmol/l
0.45
17
153
1143
11182
1.15
1.07
20.0
15.3
139.55
139.67
mmol/l
0.87
1123
10905
23
153
1.51
1.06
1.1
1.4
22.24
24.83
u/l
0.18
18
130
103
864
1.21
1.04
2.3
2.4
6.48
7.82
ug/l
0.34
86
778
17
106
1.61
1.03
3.2
2.3
—
—
—
0
0
158
1380
1.16
1.01
2.9
2.5
21.54
23.77
%
0.98
142
1189
7
35
2.01
1.00
2.9
2.1
122.66
68.12
ug/l
—
7
35
49
379
1.30
0.99
5.3
4.2
1.23
1.38
mmol/l
0.63
49
370
13
76
1.72
0.99
1.5
1.8
—
—
—
0
0
46
353
1.31
0.99
3.1
2.7
9.91
10.32
g/l
0.23
39
322
0
30
0.00
0.97
0.0
1.5
—
97.25
—
0
16
12
69
1.75
0.96
2.0
2.0
—
—
—
0
0
49
381
1.30
0.96
3.6
2.6
—
—
—
0
0
49
381
1.30
0.96
3.6
2.6
4.04
3.56
g/l
0.44
42
351
49
381
1.30
0.96
3.6
2.6
7.25
7.22
g/l
0.05
42
351
0
31
0.00
0.96
0.0
1.1
—
97.06
—
0
16
54
426
1.28
0.95
9.7
6.8
1.93
1.61
%
0.92
48
398
62
498
1.26
0.95
2.1
2.0
38.38
39.48
u/l
0.18
54
447
100
847
1.20
0.93
3.1
2.5
60.79
68.72
ml/min/173m2
1.33
34
348
41
313
1.32
0.92
3.0
3.8
32.82
31.32
mg/l
0.12
32
247
9
52
1.74
0.92
2.0
3.1
42455.56
39975.10
ug/l
—
9
52
17
110
1.55
0.90
2.9
2.3
9.85
6.72
umol/l
0.37
12
78
24
168
1.44
0.90
1.3
1.2
—
—
—
0
0
25
177
1.42
0.88
1.1
1.1
103.86
106.65
iu/ml
—
7
45
1023
9974
1.11
0.88
5.0
4.6
1.84
1.99
mu/l
0.67
944
9204
14
87
1.62
0.87
1.4
1.2
—
—
—
0
0
110
948
1.17
0.86
2.4
2.3
13.03
13.12
nmol/l
0.04
97
861
8
44
1.82
0.86
1.1
1.6
—
—
—
0
0
46
362
1.28
0.85
1.2
1.3
149.66
236.19
miu/ml
1.31
23
166
14
88
1.60
0.84
1.4
1.2
—
—
—
0
0
1143
11220
1.13
0.84
20.0
15.4
3.96
3.97
mmol/l
0.16
1118
10924
12
73
1.65
0.81
2.0
1.6
8.02
6.70
u/l
0.13
12
63
45
356
1.27
0.81
1.4
1.5
0.12
0.09
iu/ml
0.10
14
57
1094
11147
0.90
0.80
4.8
4.7
2.84
2.82
mmol/l
0.37
1007
10374
0
24
0.00
0.79
0.0
1.3
—
—
—
0
0
8
48
1.67
0.78
1.3
1.3
—
—
—
0
0
8
48
1.67
0.78
1.3
1.3
—
—
—
0
0
40
313
1.29
0.78
3.1
3.8
47.57
70.89
mg/l
0.52
31
246
1072
10930
0.90
0.77
4.4
4.2
1.44
1.45
mmol/l
0.26
992
10181
5
100
0.50
0.77
1.4
1.3
—
—
—
0
0
76
642
1.19
0.76
3.3
3.1
125.54
129.57
g/l
0.80
76
629
44
351
1.26
0.75
1.2
1.3
—
—
—
0
0
5
24
2.09
0.74
1.8
1.3
—
—
—
0
0
38
298
1.28
0.74
2.3
2.7
36.32
38.30
g/l
0.94
31
268
350
3274
1.09
0.74
3.6
3.2
7.89
7.87
mmol/l
0.03
288
2795
32
245
1.31
0.74
1.4
1.4
—
11.99
—
0
6
86
737
1.18
0.74
1.2
1.2
74.01
149.15
iu/ml
2.40
29
293
29
219
1.33
0.73
6.0
3.9
57.90
57.42
%
0.07
29
219
9
55
1.64
0.73
1.3
1.3
—
47.50
—
0
8
9
56
1.61
0.72
1.8
3.1
—
—
—
0
0
56
462
1.22
0.72
4.0
3.5
51.00
49.45
%
0.18
56
454
29
220
1.33
0.72
2.3
2.3
135.62
130.10
g/l
0.48
21
165
11
68
1.62
0.71
1.0
1.1
8.62
6.73
iu/ml
—
5
16
37
291
1.28
0.71
2.9
2.8
0.01
0.02
g/l
0.27
32
271
1036
10565
0.91
0.69
4.0
3.9
1.41
1.32
mmol/l
2.02
965
9795
200
1826
1.11
0.69
3.7
3.1
2.45
2.45
mmol/l
0.06
182
1618
9
59
1.53
0.68
2.1
1.8
—
—
—
0
0
9
59
1.53
0.68
2.1
1.8
—
—
—
0
0
11
70
1.58
0.65
1.3
1.1
—
—
—
0
0
44
359
1.23
0.64
3.5
2.7
2.69
2.88
g/l
0.69
37
329
42
343
1.23
0.61
1.6
1.4
11.36
8.73
u/l
0.49
36
280
13
88
1.48
0.60
1.3
1.5
—
—
—
0
0
8
51
1.57
0.60
1.0
1.1
112.88
95.55
%
—
8
40
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
0
20
0.00
0.60
0.0
1.2
—
74.00
—
0
7
0
20
0.00
0.60
0.0
1.2
—
84.25
—
0
8
1081
10982
0.92
0.59
4.4
4.3
4.74
4.71
mmol/l
0.53
1008
10287
38
463
0.82
0.58
1.9
1.7
8.50
4.84
mg/l
0.35
26
340
27
211
1.29
0.57
3.4
2.5
17.58
16.34
%
0.57
13
110
24
185
1.30
0.56
1.2
1.2
2.11
3.42
u/ml
—
9
60
27
212
1.28
0.55
5.5
3.6
4.19
4.26
e9/l
0.05
27
212
6
37
1.62
0.55
2.3
1.2
11.53
8.86
ug/l
—
6
37
6
37
1.62
0.55
1.0
1.1
—
—
—
0
0
269
2860
0.93
0.53
4.0
3.9
21.01
21.14
%
0.05
114
1237
6
39
1.54
0.53
4.0
2.1
1.08
0.83
ug/l
—
6
34
12
84
1.43
0.49
2.3
1.8
—
—
—
0
0
214
2005
1.08
0.46
1.7
1.5
—
—
—
0
0
10
142
0.70
0.46
1.5
1.5
—
—
—
0
0
7
49
1.43
0.46
1.1
1.1
—
—
—
0
0
23
183
1.26
0.45
1.3
1.0
2.69
2.34
u/ml
—
8
80
5
33
1.52
0.41
1.0
1.3
—
—
—
0
0
72
644
1.12
0.41
3.1
3.4
4.33
4.58
pmol/l
0.91
58
562
47
408
1.16
0.40
1.8
1.6
286.40
286.56
mu/l
0.00
42
372
10
138
0.72
0.40
1.4
1.6
—
—
—
0
0
15
194
0.77
0.40
1.5
1.5
—
—
—
0
0
8
60
1.34
0.40
1.4
1.3
—
—
—
0
0
8
61
1.31
0.39
1.3
1.1
—
—
—
0
0
313
2994
1.06
0.38
3.8
3.3
694.08
326.91
mg/l
0.50
206
1926
153
1637
0.93
0.38
1.5
1.4
—
—
—
0
0
24
197
1.22
0.38
1.2
1.1
—
13.71
—
0
11
5
37
1.35
0.37
1.2
1.1
—
—
—
0
0
9
70
1.29
0.36
2.1
1.7
—
—
—
0
0
55
488
1.13
0.36
3.4
3.2
25.42
25.19
mmol/l
0.18
55
473
23
189
1.22
0.36
1.2
1.1
—
—
—
0
0
117
1083
1.09
0.36
3.6
3.1
—
—
—
0
0
11
146
0.75
0.36
1.0
1.1
—
—
—
0
0
16
201
0.79
0.35
1.1
1.1
15.55
5.66
u/ml
0.56
11
105
1184
11740
1.07
0.35
12.5
10.1
27.90
27.62
u/l
0.14
1150
11380
6
44
1.37
0.34
1.2
1.1
—
—
—
0
0
134
1256
1.07
0.32
2.2
2.0
—
—
—
0
0
14
110
1.28
0.31
1.2
1.2
—
—
—
0
0
90
831
1.09
0.31
5.0
3.8
1.21
1.23
mmol/l
2.24
80
720
7
53
1.32
0.31
5.9
2.3
173.57
193.51
u/l
—
7
53
7
99
0.71
0.30
4.6
3.4
—
—
—
0
0
7
54
1.30
0.30
1.4
1.9
—
—
—
0
0
12
93
1.29
0.30
1.5
1.8
—
—
—
0
0
22
185
1.19
0.29
1.2
1.2
5.00
6.24
u/ml
—
8
76
49
440
1.12
0.29
1.1
1.1
—
1.03
—
0
6
7
57
1.23
0.29
5.0
1.9
—
—
—
0
0
7
57
1.23
0.29
5.0
1.9
—
—
—
0
0
85
786
1.09
0.29
3.1
2.9
160.93
185.08
ng/l
0.24
71
716
17
204
0.83
0.27
1.6
1.7
—
—
—
0
0
326
3159
1.04
0.25
4.3
3.9
17.23
8.80
mg/mmol
1.13
218
1998
27
308
0.87
0.24
1.9
2.0
195.15
207.83
pmol/l
0.29
27
290
1228
12343
0.94
0.24
25.8
19.7
135.54
136.94
g/l
2.70
1215
12177
11
87
1.27
0.24
1.0
1.1
—
—
—
0
0
11
87
1.27
0.24
1.0
1.1
—
—
—
0
0
6
83
0.72
0.24
1.3
1.4
1.37
1.56
g/l
—
6
83
37
411
0.90
0.23
1.5
1.5
—
—
—
0
0
1228
12340
0.94
0.23
25.6
19.6
4.51
4.54
e12/l
1.21
1202
12023
12
97
1.24
0.23
3.0
2.3
—
—
—
0
0
5
39
1.28
0.23
1.6
1.1
0.33
0.29
g/l
—
5
31
1227
12330
0.94
0.23
25.7
19.6
252.83
251.29
e9/l
0.34
1205
12040
11
88
1.25
0.22
1.0
1.1
—
—
—
0
0
11
88
1.25
0.22
1.0
1.1
—
—
—
0
0
11
88
1.25
0.22
1.0
1.1
—
—
—
0
0
1228
12337
0.94
0.21
25.6
19.6
6.93
6.68
e9/l
3.25
1205
12019
21
182
1.16
0.21
3.3
3.1
0.76
0.87
nmol/l
0.47
15
144
49
450
1.09
0.21
1.6
1.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
0.01
—
0
8
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
12
99
1.21
0.19
1.3
1.4
1.10
1.46
nmol/l
0.71
12
91
6
51
1.18
0.19
1.0
1.1
—
—
—
0
0
25
222
1.13
0.19
3.4
2.9
1.59
1.52
mmol/l
0.16
25
216
24
270
0.89
0.19
1.7
1.9
2.20
4.50
iu/l
—
9
98
6
52
1.15
0.19
2.8
2.2
—
—
—
0
0
10
81
1.24
0.18
9.0
15.1
563.00
803.89
nmol/l
—
10
76
7
58
1.21
0.18
1.1
1.1
78.24
86.57
u/l
—
7
58
7
58
1.21
0.18
1.1
1.1
9.70
27.67
u/l
—
7
58
30
271
1.11
0.18
2.5
2.8
0.00
0.00
g/l
-0.00
25
251
61
572
1.07
0.17
1.0
1.1
—
—
—
0
0
952
9594
0.97
0.16
19.8
16.0
15.13
14.75
%
1.13
943
9431
14
162
0.86
0.16
2.1
1.7
—
—
—
0
0
1228
12326
0.95
0.16
25.8
19.7
40.14
40.59
%
1.55
1173
11577
1015
10080
1.03
0.16
5.7
5.4
39.72
39.44
mmol/mol
0.39
941
9403
36
334
1.08
0.13
1.5
1.5
—
—
—
0
0
20
222
0.90
0.13
1.2
1.1
0.97
2.28
u/ml
0.73
13
118
12
104
1.16
0.12
1.2
1.4
203.09
165.02
pmol/l
0.63
12
104
27
249
1.09
0.12
1.2
1.2
—
—
—
0
0
35
327
1.07
0.11
1.3
1.1
—
—
—
0
0
11
126
0.87
0.11
2.7
2.4
33.45
32.37
pg
0.51
11
126
35
328
1.07
0.11
2.7
2.8
4.19
3.65
g/l
0.90
35
313
17
154
1.11
0.10
1.4
1.5
0.43
0.35
nmol/l
0.23
12
125
25
269
0.93
0.10
2.6
2.3
33.38
122.64
ug/min
2.25
13
168
22
237
0.93
0.09
1.2
1.2
240.13
265.20
u/ml
0.22
15
144
25
265
0.94
0.07
1.2
1.2
—
—
—
0
0
8
95
0.84
0.06
1.3
1.5
0.91
1.00
g/l
—
8
95
57
589
0.97
0.06
1.4
1.3
—
—
—
0
0
12
109
1.10
0.06
1.1
1.0
—
—
—
0
0
26
273
0.95
0.05
1.2
1.4
—
—
—
0
0
1057
10597
0.99
0.05
4.6
4.3
5.97
5.91
mmol/l
0.59
961
9736
35
363
0.96
0.04
1.3
1.4
—
—
—
0
0
13
140
0.93
0.04
1.1
1.1
—
—
—
0
0
208
2100
0.99
0.04
2.9
2.9
0.61
0.72
ug/l
2.05
133
1269
115
1134
1.02
0.04
2.2
1.9
—
—
—
0
0
34
329
1.03
0.03
1.3
1.1
—
—
—
0
0
23
240
0.96
0.03
1.3
1.4
—
—
—
0
0
23
240
0.96
0.03
1.2
1.4
—
—
—
0
0
10
92
1.09
0.03
1.1
1.1
—
—
—
0
0
18
189
0.95
0.03
1.1
1.1
0.33
2.15
u/ml
—
8
94
23
239
0.96
0.02
1.2
1.4
—
—
—
0
0
23
239
0.96
0.02
1.2
1.4
—
—
—
0
0
49
499
0.98
0.02
1.8
1.8
—
—
—
0
0
291
2897
1.01
0.02
1.6
1.7
1.56
1.40
mmol/l
0.59
248
2453
16
153
1.05
0.01
1.3
1.3
—
0.42
—
0
13
64
632
1.01
0.01
1.7
1.8
—
—
—
0
0
13
124
1.05
0.00
1.9
2.4
—
—
—
0
0
16
166
0.96
0.00
1.1
1.1
—
—
—
0
0
26
254
1.02
0.00
1.4
1.5
—
—
—
0
0
13
126
1.03
0.00
1.0
1.2
—
—
—
0
0
18
184
0.98
0.00
1.1
1.1
—
—
—
0
0
23
226
1.02
0.00
6.0
3.7
22.97
24.89
mg/l
0.10
15
140
54
542
1.00
0.00
1.6
1.4
27.33
27.87
iu/l
0.04
47
464
358
3579
1.00
0.00
5.1
4.5
2.03
2.19
ug/l
0.19
320
3232
15
153
0.98
0.00
1.3
1.3
0.53
0.62
nmol/l
0.57
15
146
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
6
67
0.90
0.00
1.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
7.97
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
66
0.91
-0.00
1.0
1.7
5.13
7.42
u/l
—
6
52
0
5
0.00
-0.00
0.0
4.8
—
—
—
0
0
7
74
0.95
-0.00
1.0
1.2
—
—
—
0
0
6
68
0.88
-0.00
3.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
80
1.00
-0.00
1.3
1.4
93.63
77.53
umol/l
—
8
80
5
56
0.89
-0.00
1.0
1.1
110.20
224.58
iu/ml
—
5
56
8
83
0.96
-0.00
1.1
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
1.46
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
1.80
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_MENINGBACT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MENINGBACT | 2.439 [2.05, 2.9] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.339 |
During the follow-up period (1.1.1998 — 31.12.2019), 366 out of 1921 females with G6_MENINGBACT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MENINGBACT | 2.511 [2.12, 2.98] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 528 out of 2305 males with G6_MENINGBACT died.
Mortality risk
Mortality risk for people of age
years, who have G6_MENINGBACT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.233% | 0.462% |
| 5 | 1.41% | 3.008% |
| 10 | 3.352% | 7.395% |
| 15 | 6.994% | 13.678% |
| 20 | 12.009% | 22.485% |
Relationships between endpoints
↥Index endpoint: G6_MENINGBACT – Bacterial meningitis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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