Other demyelinating diseases of the central nervous system

G6_OTHDEMYEL

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G37
  • Hospital discharge: ICD-9 341[1-9]
  • Hospital discharge: ICD-8 3410[2-9]
  • Cause of death: ICD-10 G37
  • Cause of death: ICD-9 341[1-9]
  • Cause of death: ICD-8 3410[2-9]

2 out of 7 registries used, show all original rules.

1458

4. Check minimum number of events

None

1458

5. Include endpoints

None

1458

6. Filter based on genotype QC (FinnGen only)

1458

Control definitions (FinnGen only)

Control exclude
G6_DEMYEL

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G35-G37
Name in latin
Alii morbi demyelinantes systematis nervosi centralis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8543 5445 3043
Only index persons 7717 5057 2660
Unadjusted period prevalence (%)
Whole population 0.13 0.16 0.09
Only index persons 0.16 0.19 0.10
Median age at first event (years)
Whole population 39.82 38.63 41.86
Only index persons 39.14 38.08 41.15

-FinnGen-

Key figures

All Female Male
Number of individuals 1458 1059 399
Unadjusted period prevalence (%) 0.31 0.36 0.18
Median age at first event (years) 39.28 37.77 43.29

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1322
Matched controls
13217
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
25.5
323.0
662
500
G37.9
ICD-10 Finland
Demyelinating disease of central nervous system, unspecified
+∞
323.0
1024
*
303
Kela drug reimbursment
Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)
+∞
323.0
544
*
G35
ICD-10 Finland
Multiple sclerosis
10640.8
323.0
869
*
109
Kela drug reimbursment
Multiple sclerosis
+∞
323.0
659
*
TAB00
NOMESCO Finland
Lumbar puncture
27.7
323.0
500
284
157
Kela drug reimbursment
Dimethyl fumarate, glatiramer acetate, interferon beta and teriflunomid (Multiple sclerosis)
+∞
323.0
560
*
L03AB07
ATC
interferon beta-1a; parenteral
+∞
302.0
278
*
N86
ICPC
Multiple sclerosis
1074.9
275.2
260
*
L03AX13
ATC
glatiramer acetate; parenteral
+∞
244.6
227
*
H46
ICD-10 Finland
Optic neuritis
118.9
228.3
243
25
L04AX07
ATC
dimethyl fumarate; oral
+∞
207.9
194
*
L04AA31
ATC
teriflunomide; oral
+∞
180.4
169
*
164
Kela drug reimbursment
Fingolimod
+∞
170.6
160
*
353
Kela drug reimbursment
Cladribine and fingolimod
+∞
149.9
141
*
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
41.1
134.2
169
47
R20.2
ICD-10 Finland
Paraesthesia of skin
8.1
125.3
308
475
L03AB08
ATC
interferon beta-1b; parenteral
+∞
121.8
115
*
L04AA27
ATC
fingolimod; oral
+∞
118.6
112
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
7.5
117.2
306
513
N04BB01
ATC
amantadine; oral
38.9
117.0
149
43
N07XX09
ATC
[U] dimethyl fumarate; oral
+∞
116.4
110
*
G37.3
ICD-10 Finland
Acute transverse myelitis in demyelinating disease of central nervous system
+∞
107.8
102
*
M03BX01
ATC
baclofen; systemic
25.1
101.0
144
64
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
17.5
99.7
161
104
2AB04
NOMESCO Finland
NA
940.5
90.9
88
*
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
20.3
87.9
134
73
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
7.8
87.8
217
325
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
5.8
85.3
268
556
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
11.2
77.0
151
150
G36.9
ICD-10 Finland
Acute disseminated demyelination, unspecified
+∞
75.8
72
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.0
73.5
351
1107
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
23.9
69.5
100
45
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
13.2
67.2
121
100
XA800
NOMESCO Finland
Neuropsychological investigation
7.8
67.1
163
234
XCK00
NOMESCO Finland
Perimetry
6.8
63.6
171
284
XKD06
NOMESCO Finland
Physiologic investigation of micturition
11.9
59.9
113
103
G37.2
ICD-10 Finland
Central pontine myelinolysis
+∞
58.8
56
*
L03AB13
ATC
peginterferon beta-1a; parenteral
+∞
58.8
56
*
3419X
ICD-9 Finland
Other demyelinating diseases of central nervous system, Demyelinating disease of central nervous system, unspecified
+∞
54.6
52
*
G04BD12
ATC
mirabegron; oral
5.1
53.3
183
407
H53.2
ICD-10 Finland
Diplopia
9.5
51.4
109
124
ZX120
NOMESCO Finland
Intravenous
4.2
49.8
208
563
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
35.3
49.6
64
19
F02.89*G35
ICD-10 Finland
Dementia in multiple sclerosis
+∞
49.3
47
*
G37.8
ICD-10 Finland
Other specified demyelinating diseases of central nervous system
+∞
49.3
47
*
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
25.0
48.9
69
29
N03AX12
ATC
gabapentin; oral
3.2
47.6
294
1092
XKD00
NOMESCO Finland
Uroflowmetry
4.2
46.4
191
508
N06BA07
ATC
modafinil; oral
50.1
44.2
53
11
N03AE01
ATC
clonazepam; systemic
5.0
43.6
148
323
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
16.6
42.1
68
43
34109
ICD-8 Finland
Other demyelinating diseases of central nervous system, Unspecified
+∞
41.9
40
*
UKC02
NOMESCO Finland
Cystoscopy
3.5
41.3
214
691
G04BD09
ATC
trospium; oral
10.5
41.1
82
83
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
4.3
40.7
163
420
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
8.9
39.8
87
104
4AA23
NOMESCO Finland
NA
377.6
37.2
37
*
N03AX16
ATC
pregabalin; oral
2.4
35.9
365
1794
XKC03
NOMESCO Finland
Water cystometry
7.1
35.6
90
135
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
4.4
35.3
136
337
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
33.4
505
2970
L04AA40
ATC
cladribine; oral
+∞
31.4
30
*
3400A
ICD-9 Finland
Multiple sclerosis[SCLEROSIS MULTIPLEX (DISSEMINATA)]
+∞
31.4
30
*
R1250
NOMESCO Finland
Evaluation of functional capability
8.0
30.8
71
93
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.2
29.8
375
2013
G04BD08
ATC
solifenacin; oral
4.8
28.9
99
217
N31.9
ICD-10 Finland
Neuromuscular dysfunction of bladder, unspecified
14.2
28.2
48
35
TKC22
NOMESCO Finland
Catheterisation instruction
10.6
28.1
55
54
L28
ICPC
Limited function/disability (L)
2.9
27.2
182
694
H53.1
ICD-10 Finland
Subjective visual disturbances
3.6
26.8
127
377
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
12.1
26.3
48
41
G36.0
ICD-10 Finland
Neuromyelitis optica [Devic]
+∞
26.1
25
*
TAB22
NOMESCO Finland
Stoppin epidural fluid escape with coagulated blood
6.9
25.5
65
99
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.5
25.4
127
393
R33
ICD-10 Finland
Retention of urine
4.7
24.9
88
199
N29
ICPC
Neurological sympt/complt other
9.0
24.9
53
61
G37.0
ICD-10 Finland
Diffuse sclerosis
+∞
24.0
23
*
H48.1*G35
ICD-10 Finland
Retrobulbar neuritis in multiple sclerosis
+∞
24.0
23
*
SPAT1229
SPAT
Assessment of need for aid
3.7
23.6
107
306
XCD10
NOMESCO Finland
Electrophysiological examination of eye
6.5
23.6
62
99
AA1AD
NOMESCO Finland
CT of head and brain
2.2
23.5
273
1392
L01BB04
ATC
cladribine; systemic
+∞
23.0
22
*
A02BC02
ATC
pantoprazole; systemic
1.8
22.3
811
6227
G04.9
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis, unspecified
24.4
22.2
31
13
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.4
22.1
211
976
R35
ICD-10 Finland
Polyuria
4.0
22.0
92
245
G04BD04
ATC
oxybutynin; oral, transdermal
4.3
22.0
84
206
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
5.3
21.9
68
134
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
4.4
21.4
79
187
H02AB04
ATC
methylprednisolone; systemic
2.3
21.2
222
1071
XKD03
NOMESCO Finland
Urethral pressure profilometry
6.4
21.1
56
91
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.8
20.7
145
565
N32.83
ICD-10 Finland
Nozzle synergy in the bladder neck
30.6
20.6
27
9
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
4.8
20.6
70
153
N28
ICPC
Limited function/disability (N)
11.5
20.5
38
34
CS494
NOMESCO Finland
Other visual field testing
6.8
20.1
51
78
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
9.8
19.9
40
42
34099
ICD-8 Finland
Multiple sclerosis
+∞
19.8
19
*
G82.2
ICD-10 Finland
Paraplegia, unspecified
25.0
19.6
27
11
R42
ICD-10 Finland
Dizziness and giddiness
2.1
19.5
261
1402
N05CF01
ATC
zopiclone; oral
1.8
19.2
382
2385
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
20.4
19.1
28
14
N99
ICPC
Neurological disease other
12.0
18.8
34
29
4AA36
NOMESCO Finland
NA
+∞
18.8
18
*
34108
ICD-8 Finland
Other demyelinating diseases of central nervous system, Alii definiti
+∞
18.8
18
*
N06AX21
ATC
duloxetine; oral
2.3
18.5
184
864
TKC20
NOMESCO Finland
Catheterisation of bladder
3.5
18.4
87
258
G95.8
ICD-10 Finland
Other specified diseases of spinal cord
30.5
18.4
24
8
SPAT1215
SPAT
Assessment of need for medical rehabilitation
3.4
18.2
89
271
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.5
18.0
156
684
G37.1
ICD-10 Finland
Central demyelination of corpus callosum
+∞
17.7
17
*
N03AF01
ATC
carbamazepine; oral, rectal
3.6
17.6
82
240
N06AX16
ATC
venlafaxine; oral
2.0
17.4
240
1301
N31.2
ICD-10 Finland
Flaccid neuropathic bladder, not elsewhere classified
12.2
17.4
31
26
G04BD07
ATC
tolterodine; oral
4.2
17.3
67
167
C10AC01
ATC
colestyramine; oral
4.6
17.3
61
139
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
11.3
17.3
32
29
J01EA01
ATC
trimethoprim; systemic
1.8
17.2
343
2132
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.2
16.8
90
294
H51.2
ICD-10 Finland
Internuclear ophthalmoplegia
91.2
16.6
18
*
L04AX01
ATC
azathioprine; systemic
3.2
16.3
87
283
KCV12
NOMESCO Finland
Urinary bladder endoscopic botulin therapy
12.4
15.9
28
23
R4110
NOMESCO Finland
Physiotherapy
1.8
15.7
323
2015
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.8
15.7
107
409
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
3.1
15.4
87
293
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
5.7
15.2
43
77
G36.8
ICD-10 Finland
Other specified acute disseminated demyelination
+∞
14.6
14
*
N06AA09
ATC
amitriptyline; systemic
2.4
14.4
128
567
N31.1
ICD-10 Finland
Reflex neuropathic bladder, not elsewhere classified
11.0
14.0
26
24
R4150
NOMESCO Finland
Neuropsychological rehabilitation
8.3
13.8
30
37
SPAT1216
SPAT
Assessment of functional ability
2.2
13.8
146
706
R4120
NOMESCO Finland
Occupational therapy
2.7
13.5
95
370
SPAT1231
SPAT
Assessment of adjustments needed in living environment
7.5
13.5
31
42
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.7
13.1
92
359
G50.0
ICD-10 Finland
Trigeminal neuralgia
5.6
12.9
37
68
A28
ICPC
Limited function/disability NOS
2.3
12.7
115
516
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
12.6
265
1652
H55
ICD-10 Finland
Nystagmus and other irregular eye movements
11.1
12.5
23
21
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.8
12.3
77
281
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
4.6
12.3
42
94
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.5
12.2
94
387
R39.1
ICD-10 Finland
Other difficulties with micturition
4.5
12.2
42
95
G04BD11
ATC
fesoterodine; oral
4.8
12.2
40
86
G61.0
ICD-10 Finland
Guillain-Barré syndrome
16.0
12.2
19
12
N32.82
ICD-10 Finland
Instability of the detrusor vesicae muscle
6.6
12.1
30
46
H53.9
ICD-10 Finland
Visual disturbance, unspecified
3.9
12.0
49
130
R51.80
ICD-10 Finland
Headache
1.8
12.0
228
1376
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.3
12.0
117
541
N30.0
ICD-10 Finland
Acute cystitis
1.9
12.0
181
1007
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
11.8
161
864
N31.8
ICD-10 Finland
Other neuromuscular dysfunction of bladder
19.1
11.6
17
9
R20.1
ICD-10 Finland
Hypoaesthesia of skin
9.3
11.5
23
25
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
3.8
11.4
48
131
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
5.3
11.2
33
63
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
17.2
11.2
17
10
R27.0
ICD-10 Finland
Ataxia, unspecified
20.2
11.1
16
8
H30.2
ICD-10 Finland
Posterior cyclitis
15.6
10.8
17
11
G81.9
ICD-10 Finland
Hemiplegia, unspecified
6.8
10.7
26
39
H57.1
ICD-10 Finland
Ocular pain
3.2
10.7
55
177
H47.2
ICD-10 Finland
Optic atrophy
14.3
10.5
17
12
U13
ICPC
Bladder symptom/complaint other
3.7
10.5
45
126
G04.8
ICD-10 Finland
Other encephalitis, myelitis and encephalomyelitis
110.9
10.4
11
*
NA1CM
NOMESCO Finland
Cervical spine extensive MRI examination with 3 Tesla magnet
18.9
10.3
15
8
N31.0
ICD-10 Finland
Uninhibited neuropathic bladder, not elsewhere classified
13.2
10.2
17
13
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.9
10.1
144
783
XCK10
NOMESCO Finland
Photography of fundus of eye
2.2
10.0
101
477
M03BX02
ATC
tizanidine; oral
1.5
9.9
826
7040
N03AF02
ATC
oxcarbazepine; oral
2.9
9.8
57
200
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.9
9.8
153
864
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
4.8
9.7
31
66
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.0
9.6
117
601
3773B
ICD-9 Finland
Disorders of optic nerve and visual pathways, Optic neuritis[NEURITIS RETROBULBARIS]
100.7
9.4
10
*
36703
ICD-8 Finland
Inflammation of optic nerve and retina, Neuritis optica, retrobulbaris
100.7
9.4
10
*
H02AB06
ATC
prednisolone; systemic
1.5
9.4
536
4220
3418X
ICD-9 Finland
Other demyelinating diseases of central nervous system
+∞
9.4
9
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
3.1
9.3
50
167
A06AD11
ATC
lactulose; oral
2.0
9.3
124
658
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.5
9.2
72
298
R20.8
ICD-10 Finland
Other and unspecified disturbances of skin sensation
7.1
9.0
21
30
N18
ICPC
Paralysis/weakness
5.5
8.9
25
46
R52.2
ICD-10 Finland
Other chronic pain
3.0
8.7
50
173
6BA02
NOMESCO Finland
NA
14.1
8.7
14
10
WW400
NOMESCO Finland
Plasmaferesis
50.3
8.7
10
*
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
7.7
8.7
19
25
J01MA02
ATC
ciprofloxacin; systemic
1.5
8.6
406
3062
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
8.6
494
3879
SPAT1293
SPAT
Other function in accordance with rehabilitation guidance nomenclature
8.3
8.6
18
22
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.6
8.5
59
232
H53.4
ICD-10 Finland
Visual field defects
3.9
8.4
33
87
G96.9
ICD-10 Finland
Disorder of central nervous system, unspecified
+∞
8.3
8
*
G37.5
ICD-10 Finland
Concentric sclerosis [Baló]
+∞
8.3
8
*
RS221
NOMESCO Finland
NA
4.2
8.3
30
73
G04CA02
ATC
tamsulosin; oral
1.9
8.3
128
718
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
9.5
8.3
16
17
H25.8
ICD-10 Finland
Other senile cataract
2.6
8.2
57
225
TKC10
NOMESCO Finland
Percutaneous puncture of bladder
7.6
8.2
18
24
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
1.9
8.1
114
619
H02AB07
ATC
prednisone; oral
1.7
8.1
162
989
R47.1
ICD-10 Finland
Dysarthria and anarthria
9.0
8.0
16
18
NA7CM
NOMESCO Finland
Spine and spinal cord extensive MRI examination with 3 Tesla magnet
22.2
8.0
11
5
119
Kela drug reimbursment
Trigeminal neuralgia or glossofaryngeusneuralgia
13.1
7.9
13
10
R20.0
ICD-10 Finland
Anaesthesia of skin
5.7
7.8
21
37
WX110
NOMESCO Finland
Local anesthesy
1.4
7.8
891
7858
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
3.5
7.8
34
98
XA402
NOMESCO Finland
ENMG
3.3
7.8
37
114
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
3.9
7.7
30
79
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.7
7.5
49
186
N06
ICPC
Sensation disturbance other
5.5
7.5
21
39
N06AB04
ATC
citalopram; systemic
1.5
7.5
261
1838
SPAT1167
SPAT
Insertion of urinary catheter
4.4
7.3
25
58
N02BE01
ATC
paracetamol; systemic, rectal
1.5
7.3
1052
9620
RS121
NOMESCO Finland
NA
6.9
7.3
17
25
H48.1
ICD-10 Finland
Retrobulbar neuritis in diseases classified elsewhere
+∞
7.3
7
*
SPAT1263
SPAT
Sampling
1.4
7.2
491
3940
Z43.5
ICD-10 Finland
Attention to cystostomy
15.8
7.2
11
7
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
3.5
7.2
32
94
H04.10
ICD-10 Finland
Dry eye syndrome
1.8
7.2
114
646
SPAT1262
SPAT
Handing over of treatment supplies
1.7
7.2
165
1046
R60.0
ICD-10 Finland
Localized oedema
1.9
7.2
102
555
G95.9
ICD-10 Finland
Disease of spinal cord, unspecified
20.1
7.1
10
5
SPAT1301
SPAT
No procedures
1.4
7.1
332
2485
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.8
7.1
113
643
SPAT1224
SPAT
Implementation of speech therapy rehabilitation plan
5.7
7.1
19
34
S97
ICPC
Chronic ulcer skin
2.8
7.1
45
167
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.9
7.1
99
536
U04
ICPC
Incontinence urine
2.8
6.9
42
154
G57.3
ICD-10 Finland
Lesion of lateral popliteal nerve
4.3
6.9
24
57
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.9
6.8
97
530
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.2
6.8
67
315
R13
ICD-10 Finland
Dysphagia
2.2
6.8
67
316
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.6
6.7
160
1028
SAA03
NOMESCO Finland
Extended examination of mouth
1.4
6.6
490
3974
A06AC51
ATC
ispaghula, combinations; systemic
2.4
6.5
55
239
359
Kela drug reimbursment
Mirabegroni
10.1
6.5
12
12
RS222
NOMESCO Finland
NA
4.2
6.5
23
56
J05AB11
ATC
valaciclovir; oral
1.6
6.5
157
1011
M79.6
ICD-10 Finland
Pain in limb
1.4
6.5
397
3120
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
6.4
419
3328
R15
ICD-10 Finland
Faecal incontinence
3.2
6.4
31
99
G97.1
ICD-10 Finland
Other reaction to spinal and lumbar puncture
8.2
6.3
13
16
SPAT1325
SPAT
Vaccination
1.4
6.3
304
2284
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
3.6
6.3
26
73
XX1ZW
NOMESCO Finland
Very extensive written report from radiologist
9.3
6.3
12
13
R93.0
ICD-10 Finland
Abnormal findings on diagnostic imaging of skull and head, not elsewhere classified
18.1
6.3
9
5
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
2.4
6.2
51
221
5AB01
NOMESCO Finland
NA
26.8
6.2
8
*
Z73.6
ICD-10 Finland
Limitation of activities due to disability
7.1
6.2
14
20
J01CA08
ATC
pivmecillinam; oral
1.3
6.1
525
4346
WX408
NOMESCO Finland
General anesthesy, balanced
1.4
6.1
288
2151
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
12.6
6.1
10
8
N04BC05
ATC
pramipexole; oral
2.1
6.1
67
332
TPH04
NOMESCO Finland
Cathetrisation of vein
1.5
6.0
204
1425
R53
ICD-10 Finland
Malaise and fatigue
1.5
6.0
223
1588
N04BD01
ATC
selegiline; oral
5.2
6.0
17
33

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
311
124
31.61
307.65
1.1
1.1
—
—
—
0
0
327
266
15.56
307.65
1.2
1.5
9.2
12.1
e6/l
0.36
250
213
309
181
21.39
307.65
1.2
1.2
—
—
—
0
0
390
292
17.87
307.65
1.2
1.4
416.5
499.1
mg/l
1.88
379
276
317
268
14.84
307.65
1.2
1.3
3.5
3.7
mmol/l
2.15
296
251
342
93
47.74
307.65
1.1
1.1
212.4
224.4
mg/l
0.35
300
78
287
82
43.33
307.65
1.3
1.2
—
—
—
0
0
327
266
15.56
307.65
1.2
1.6
653.0
1927.4
e6/l
0.56
263
219
573
875
10.14
307.65
3.3
2.6
10.1
10.6
g/l
2.12
523
804
347
241
18.58
307.65
1.2
1.6
—
—
—
0
0
351
99
46.38
307.65
1.2
1.2
50.7
32.9
mg/l
4.85
280
81
194
89
24.99
267.67
3.8
2.2
1.2
1.3
e9/l
0.31
88
57
139
20
76.72
258.46
1.0
1.1
—
—
—
0
0
133
19
76.93
247.44
1.0
1.1
5.0
5.7
mg/g
0.50
124
19
196
112
20.06
245.65
1.2
1.7
—
—
—
0
0
156
62
28.06
226.55
4.2
2.2
0.3
0.2
e9/l
1.89
132
55
157
64
27.37
225.92
4.2
2.2
447.8
578.4
e6/l
1.06
132
55
159
69
25.74
223.50
2.8
1.9
15.3
12.2
%
1.07
75
35
415
890
6.12
193.43
2.6
2.3
33.5
21.7
au/ml
—
10
77
397
823
6.25
191.69
1.4
1.3
13.5
29.1
au/ml
—
6
44
904
3715
4.77
188.41
10.1
5.8
—
—
—
0
0
151
87
19.25
187.65
2.5
2.1
50.0
36.1
%
—
51
7
170
124
15.39
187.14
1.3
1.8
—
—
—
0
0
352
686
6.45
180.51
3.2
1.7
1.2
1.4
g/l
0.88
346
637
117
55
23.04
158.62
1.2
1.1
1482.7
1465.2
miu/ml
0.04
117
55
126
75
18.29
153.73
4.7
2.2
1020.2
684.2
e6/l
2.82
83
24
1097
5936
4.43
140.55
11.8
5.7
0.6
0.5
e9/l
1.88
1005
5232
1031
5349
4.17
140.30
11.4
5.8
0.8
0.7
%
6.87
1008
5017
86
23
39.67
140.18
3.2
1.6
43.0
226.2
e6/l
1.97
37
13
1096
5957
4.38
138.75
11.8
5.7
0.0
0.0
e9/l
0.01
1005
5239
123
88
15.17
136.19
1.2
1.5
1.7
1.9
mmol/l
1.91
117
83
1047
5561
4.13
135.87
11.4
5.7
3.0
2.8
%
1.85
1023
5206
1051
5599
4.14
135.73
11.6
5.9
9.0
8.1
%
19.80
1029
5290
1106
6176
4.28
131.48
11.9
6.0
0.2
0.2
e9/l
0.03
1020
5537
1102
6154
4.24
130.60
11.8
5.7
1.7
2.0
e9/l
13.50
1015
5535
1059
5809
4.01
127.59
11.5
5.7
26.9
29.2
%
11.55
1033
5469
86
32
28.50
126.90
2.2
2.1
—
—
—
0
0
1046
5744
3.91
124.54
11.1
5.5
58.5
56.6
%
6.58
1021
5420
1119
6814
3.76
104.90
12.8
8.8
3.8
4.0
e9/l
3.69
1028
6011
632
2750
3.29
104.82
4.1
2.6
—
—
—
0
0
627
2761
3.23
101.17
4.1
2.7
0.1
0.3
e6/l
5.42
524
2027
524
2074
3.38
101.06
3.4
2.3
4.7
7.1
e6/l
3.57
487
1812
665
3032
3.19
101.04
4.4
2.8
15.3
111.9
e6/l
2.24
564
2276
81
57
14.99
90.09
1.1
1.6
95.2
68.0
%
—
14
8
473
1924
3.16
84.93
3.5
2.4
542.6
541.9
mosm/kgh2o
0.02
435
1640
725
3731
2.88
84.69
5.4
3.2
43.1
76.8
e6/l
1.14
587
2487
843
4762
2.83
81.27
2.5
2.2
86.5
74.0
nmol/l
21.84
790
4417
333
1158
3.43
76.73
1.3
1.5
—
—
—
0
0
767
4273
2.68
73.63
3.8
4.7
37.3
36.6
g/l
3.51
714
4009
1111
7530
3.00
70.97
7.5
3.7
62.4
565.8
e6/l
—
7
79
860
5228
2.57
66.50
12.9
8.3
0.0
0.0
e9/l
0.12
733
4292
1146
8076
2.96
64.57
6.9
3.8
—
—
—
0
0
552
2934
2.42
54.29
3.9
2.4
—
—
—
0
0
49
37
13.67
52.12
1.2
1.1
210.4
552.8
ng/l
—
14
6
388
1796
2.58
51.01
1.5
1.6
—
—
—
0
0
231
850
3.04
46.83
5.5
4.2
0.0
0.1
%
1.15
38
188
353
1621
2.55
46.71
3.6
2.4
0.9
1.3
e6/l
0.63
207
878
236
894
2.96
45.35
5.6
4.2
0.0
0.2
%
3.38
43
219
243
944
2.89
44.55
5.5
4.1
0.8
1.0
%
0.22
45
243
322
1446
2.57
44.42
1.7
2.1
29.1
29.4
s
0.50
305
1397
225
864
2.90
42.01
5.4
4.0
0.3
0.7
%
2.07
35
179
99
226
4.63
40.46
3.8
4.1
3.8
4.2
e9/l
0.85
99
226
853
5888
2.08
39.85
5.5
3.1
0.0
0.0
estimate
1.06
244
1072
844
5820
2.07
39.33
5.4
3.1
0.0
0.0
estimate
0.50
240
1099
99
232
4.51
39.15
3.9
4.4
59.6
57.0
%
1.34
99
232
321
1525
2.42
38.72
3.9
2.5
5.4
3.1
e6/l
1.85
178
788
844
5842
2.06
38.65
6.9
4.2
0.0
0.0
estimate
0.35
247
1131
178
638
3.04
37.43
1.7
2.7
68.7
67.9
g/l
0.80
167
597
361
1862
2.25
35.63
1.4
1.4
430.2
549.8
titre
1.01
86
364
497
2923
2.06
34.83
2.5
2.1
147.9
190.4
u/l
0.81
476
2777
867
6206
1.98
34.39
4.9
4.5
6.2
6.5
mmol/l
6.88
819
5687
478
2791
2.06
34.02
1.7
1.7
—
—
—
0
0
460
2656
2.07
33.69
2.3
1.4
2.1
2.3
g/l
1.37
354
1711
108
308
3.71
32.67
1.3
1.2
—
—
—
0
0
50
76
6.78
31.60
4.4
2.4
47.2
45.5
%
0.15
17
25
569
3632
1.93
30.67
5.8
6.4
1.1
1.1
inr
0.12
196
1172
785
5601
1.87
29.60
5.0
5.9
9.4
10.5
umol/l
4.53
762
5303
58
110
5.45
29.34
1.2
1.9
—
—
—
0
0
223
1031
2.37
27.91
6.8
3.3
—
—
—
0
0
481
3014
1.89
26.60
9.0
4.3
—
—
—
0
0
1072
8627
1.92
25.81
6.5
7.0
72.7
74.7
u/l
1.16
1014
8144
462
2890
1.88
25.48
7.9
6.5
—
—
—
0
0
627
4340
1.78
24.58
6.0
5.7
1.2
1.2
mmol/l
0.20
559
3989
420
2576
1.89
24.47
4.8
3.1
—
—
—
0
0
131
517
2.69
22.76
1.8
2.2
—
—
—
0
0
1367
12244
2.87
22.37
14.7
11.1
17.8
20.3
mg/l
2.10
1097
9422
674
4874
1.71
21.81
6.5
6.2
1.2
1.2
mmol/l
0.54
534
4135
511
3429
1.75
21.60
1.9
1.9
—
—
—
0
0
191
919
2.24
21.50
2.5
2.2
739.4
5340.7
u/l
5.45
53
381
429
2747
1.80
21.24
3.7
3.6
97.2
96.2
%
0.36
417
2659
460
3058
1.74
19.74
6.9
3.3
0.0
0.0
estimate
1.28
249
1112
1049
8691
1.74
19.33
3.8
3.8
10.3
9.9
mm/h
0.45
975
8167
1337
12014
2.36
18.76
14.5
11.6
139.6
139.6
mmol/l
0.05
1312
11711
1339
12054
2.36
18.46
14.5
11.7
3.9
3.9
mmol/l
1.99
1310
11728
429
2893
1.68
17.00
3.3
3.8
7.4
7.4
ph
0.39
98
565
60
183
3.38
16.39
1.2
1.9
—
1462.9
—
0
7
1402
13010
3.02
16.02
14.9
9.0
26.5
26.3
u/l
0.20
1373
12667
396
2664
1.67
15.62
3.2
3.0
—
—
—
0
0
529
3893
1.56
14.12
1.8
1.8
95.7
97.5
pmol/l
0.42
289
2099
469
3387
1.57
13.47
5.2
2.7
—
—
—
0
0
1035
8902
1.56
12.93
4.3
2.9
40.2
40.8
u/l
0.10
989
8509
44
130
3.46
12.67
1.5
1.4
0.3
0.4
g/l
1.10
31
90
44
130
3.46
12.67
1.5
1.4
6.4
6.8
g/l
0.24
31
91
44
130
3.46
12.67
1.5
1.4
3.0
3.0
g/l
0.02
31
90
44
133
3.38
12.24
1.5
1.4
—
—
—
0
0
54
200
2.77
10.65
1.6
1.7
0.7
0.8
g/l
0.27
39
151
479
3638
1.47
10.25
3.1
2.9
36.6
33.2
ng/l
0.08
271
1942
337
2397
1.53
9.88
4.5
4.1
—
—
—
0
0
97
485
2.07
9.82
1.6
1.3
—
—
—
0
0
74
338
2.25
9.41
1.3
1.3
55.0
94.9
titre
—
10
37
150
889
1.77
9.09
2.9
2.5
4.1
4.2
e9/l
0.38
127
749
227
1514
1.59
8.77
1.6
1.6
1142.1
1188.6
nmol/l
0.21
171
1202
1234
11363
1.56
8.46
5.3
4.7
1.7
2.0
mu/l
1.09
1156
10726
235
1596
1.56
8.38
3.1
3.4
0.8
0.8
mmol/l
0.01
219
1509
132
785
1.75
7.91
2.9
3.3
1.2
1.2
mmol/l
1.11
113
683
24
66
3.68
7.75
1.6
3.6
735.0
816.7
u/ml
0.09
24
66
12
8
15.11
7.72
1.3
4.0
—
—
—
0
0
1373
13047
1.90
7.71
14.2
10.3
—
—
—
0
0
12
18
6.71
7.61
1.1
1.0
87.0
56.4
%
—
6
5
63
295
2.19
7.59
2.0
2.9
—
—
—
0
0
52
226
2.35
7.47
1.5
1.9
39.2
38.8
g/l
0.17
45
206
1163
10652
1.45
7.45
20.7
13.4
13.4
13.5
%
4.50
1149
10445
440
3452
1.39
7.40
2.4
2.5
52.5
55.0
u/l
1.08
408
3233
1019
11124
0.72
7.19
21.8
13.8
332.7
332.9
g/l
0.40
1014
11047
285
2110
1.44
6.57
1.5
1.4
19.6
20.9
nmol/l
0.82
255
1875
186
1272
1.53
6.38
2.1
2.8
6.1
7.1
umol/l
0.55
161
1093
175
1188
1.54
6.20
5.4
5.9
1.0
1.0
mmol/l
1.36
162
1121
426
3430
1.34
5.84
2.4
3.2
2.3
2.3
mmol/l
0.48
369
3114
47
219
2.18
5.80
1.3
2.0
—
3.4
—
0
5
41
182
2.29
5.68
1.6
1.4
—
—
—
0
0
1130
12024
0.73
5.52
3.7
3.7
1.5
1.5
mmol/l
0.06
1041
11404
17
47
3.65
5.49
4.1
2.5
—
—
—
0
0
139
927
1.55
5.35
4.1
3.5
—
—
—
0
0
9
8
11.31
5.29
1.0
1.0
—
—
—
0
0
122
796
1.58
5.16
6.0
3.2
—
—
—
0
0
115
747
1.59
4.97
6.2
8.1
7.0
8.0
mmol/l
1.25
110
716
46
232
2.01
4.68
1.2
1.3
3.9
6.1
u/ml
0.51
17
94
64
1083
0.57
4.65
1.6
1.7
—
—
—
0
0
1156
12197
0.75
4.62
4.0
4.0
2.9
2.9
mmol/l
0.13
1060
11538
1425
13897
2.12
4.58
25.9
16.4
265.5
261.0
e9/l
1.92
1410
13634
25
98
2.58
4.56
1.1
1.1
—
—
—
0
0
1058
9789
1.29
4.56
4.3
4.1
14.7
14.4
pmol/l
4.40
967
9188
1426
13913
2.14
4.53
25.7
16.3
90.7
90.3
fl
3.19
1416
13777
1426
13915
2.13
4.49
25.7
16.3
30.2
30.1
pg
1.24
1416
13777
1426
13916
2.13
4.48
25.8
16.3
4.5
4.5
e12/l
0.56
1411
13636
1426
13918
2.12
4.44
25.9
16.4
6.6
6.7
e9/l
1.07
1408
13630
47
244
1.96
4.43
1.1
1.1
—
—
—
0
0
1143
12065
0.76
4.43
3.7
3.8
4.8
4.8
mmol/l
0.75
1060
11481
100
648
1.58
4.39
1.1
1.3
220.1
217.1
miu/ml
0.03
41
333
84
522
1.65
4.37
1.6
1.6
—
—
—
0
0
1426
13922
2.11
4.37
26.0
16.4
136.0
136.2
g/l
0.29
1416
13783
17
55
3.12
4.37
4.1
2.5
—
—
—
0
0
41
204
2.04
4.35
1.4
1.3
—
—
—
0
0
23
89
2.61
4.31
1.1
1.2
—
—
—
0
0
162
1170
1.43
4.24
2.2
2.1
358.0
373.6
nmol/l
0.53
148
1096
16
51
3.16
4.21
1.3
1.1
—
—
—
0
0
13
36
3.63
4.21
1.2
1.2
—
—
—
0
0
182
1347
1.40
4.15
1.4
1.4
—
—
—
0
0
134
1871
0.69
4.14
1.2
1.3
—
—
—
0
0
1093
11579
0.78
4.10
3.4
3.4
1.3
1.3
mmol/l
0.41
1008
10964
41
210
1.98
4.04
2.0
3.4
34.5
33.3
umol/l
0.10
34
191
28
125
2.26
3.91
1.3
1.5
47.9
72.0
mmol/l
2.88
20
110
177
1320
1.39
3.87
2.6
1.6
—
—
—
0
0
8
11
7.31
3.86
1.1
1.0
—
—
—
0
0
23
96
2.42
3.73
3.8
3.6
—
—
—
0
0
60
357
1.71
3.71
1.3
1.3
2.1
2.4
u/ml
—
7
39
31
149
2.10
3.64
1.3
1.2
—
—
—
0
0
32
157
2.06
3.57
2.0
2.3
—
—
—
0
0
259
2071
1.30
3.56
1.6
1.6
459.5
26969793.3
pmol/l
2.06
223
1828
39
207
1.91
3.51
2.6
2.8
2.5
2.3
mmol/l
0.26
30
128
17
63
2.72
3.49
1.4
1.7
140.6
142.5
nmol/l
0.06
17
63
30
146
2.08
3.43
1.2
1.8
—
20.1
—
0
8
226
1784
1.32
3.41
3.1
3.3
242.6
483.3
ng/l
0.72
122
1095
442
5099
0.81
3.39
2.3
2.4
—
—
—
0
0
67
423
1.61
3.34
1.1
1.2
—
—
—
0
0
126
911
1.42
3.31
2.3
2.3
0.2
0.2
g/l
0.01
120
858
64
401
1.62
3.29
3.6
3.2
—
—
—
0
0
10
28
3.59
3.20
3.8
2.2
—
—
—
0
0
54
327
1.68
3.18
1.3
1.9
1.5
1.4
g/l
0.14
47
284
17
67
2.56
3.13
2.1
2.0
2.6
2.8
u/field
—
9
34
9
20
4.52
3.11
2.2
1.1
—
—
—
0
0
53
325
1.65
2.99
2.1
2.1
2.9
2.5
ug/l
0.06
41
298
5
5
10.03
2.98
1.0
1.0
—
—
—
0
0
90
624
1.47
2.98
2.1
2.7
67.1
74.8
e9/l
1.27
63
457
141
1060
1.37
2.97
9.6
7.1
103.6
104.5
mmol/l
0.86
136
1043
17
69
2.48
2.96
1.5
1.2
—
—
—
0
0
70
463
1.54
2.90
1.5
2.1
21.0
21.0
s
0.01
59
395
141
1065
1.36
2.88
1.2
1.2
—
—
—
0
0
76
1100
0.67
2.87
1.5
1.4
—
—
—
0
0
7
13
5.40
2.87
1.6
1.2
—
—
—
0
0
186
1472
1.30
2.77
2.2
1.9
—
—
—
0
0
127
951
1.37
2.75
11.1
9.3
12.7
13.0
kpa
0.27
117
914
127
951
1.37
2.75
11.2
9.3
5.0
5.1
kpa
0.34
116
911
7
14
5.02
2.73
1.6
1.1
—
—
—
0
0
21
98
2.16
2.71
2.3
2.8
—
—
—
0
0
40
235
1.72
2.67
1.0
1.1
—
—
—
0
0
67
452
1.51
2.57
14.2
13.1
—
—
—
0
0
292
2466
1.23
2.52
6.3
3.3
1.0
1.0
kg/l
0.08
38
336
151
1911
0.77
2.50
1.4
1.4
—
—
—
0
0
12
284
0.42
2.48
1.1
1.0
3.6
2.7
u/ml
—
7
101
41
249
1.67
2.45
1.9
2.3
—
—
—
0
0
18
83
2.18
2.41
2.2
1.4
—
—
—
0
0
19
90
2.13
2.39
1.1
1.0
—
—
—
0
0
124
949
1.34
2.36
11.3
9.3
1.1
0.9
mmol/l
0.23
91
739
324
2792
1.21
2.28
1.6
1.8
0.9
0.9
mg/l
0.04
216
2081
77
549
1.42
2.26
3.7
3.1
7.4
7.4
ph
0.64
11
68
26
142
1.85
2.24
1.8
1.6
—
—
—
0
0
24
130
1.86
2.13
1.4
1.4
295.0
370.9
pmol/l
0.27
16
101
30
175
1.73
2.10
2.5
2.0
15.5
16.6
%
—
10
81
8
25
3.21
2.09
8.0
9.9
—
—
—
0
0
546
4953
1.16
2.08
2.0
2.0
—
—
—
0
0
355
3110
1.19
2.08
1.3
1.3
1.4
1.5
u/ml
0.05
83
879
12
260
0.46
2.03
1.1
1.1
4.2
4.7
u/ml
—
5
96
823
7707
1.16
2.02
3.3
3.0
—
—
—
0
0
308
2679
1.19
1.95
2.2
2.0
2.8
2.8
mg/l
0.03
270
2326
21
371
0.56
1.92
1.1
1.1
0.2
1.7
u/ml
—
6
140
17
85
2.01
1.90
1.1
1.0
—
—
—
0
0
107
830
1.31
1.90
12.1
10.1
96.4
96.3
%
0.02
101
807
115
901
1.30
1.90
2.9
2.5
1.6
1.8
%
1.72
100
812
274
2364
1.20
1.90
1.2
1.3
18.5
27.6
iu/ml
0.85
67
728
175
1449
1.24
1.84
2.2
2.2
2.4
2.4
g/l
0.16
162
1350
29
175
1.67
1.83
1.2
1.3
—
41.3
—
0
12
123
979
1.28
1.81
1.2
1.3
80.0
224.1
u/ml
4.21
110
913
190
1599
1.22
1.72
2.3
2.2
13.6
14.3
umol/l
0.57
176
1487
6
19
3.17
1.66
1.7
2.4
—
—
—
0
0
5
14
3.58
1.61
1.2
1.3
—
—
—
0
0
159
1326
1.22
1.59
2.3
2.3
23.6
24.2
%
0.19
136
1153
6
20
3.01
1.58
4.8
3.9
56.1
50.1
%
—
6
20
99
787
1.28
1.51
13.2
10.2
122.6
123.1
g/l
0.11
92
764
6
21
2.86
1.50
2.8
1.3
2.4
2.6
mmol/l
—
6
21
19
319
0.59
1.50
1.1
1.1
0.0
1.4
u/ml
—
6
134
20
116
1.73
1.49
2.8
2.5
—
—
—
0
0
9
37
2.44
1.48
1.0
1.2
—
—
—
0
0
21
341
0.61
1.46
1.0
1.1
0.8
6.6
u/ml
—
10
180
7
28
2.51
1.45
1.0
1.1
—
—
—
0
0
7
28
2.51
1.45
1.0
1.1
—
—
—
0
0
7
28
2.51
1.45
1.0
1.1
—
—
—
0
0
18
102
1.77
1.45
1.2
1.1
1.0
1.0
ratio
—
6
47
203
1750
1.19
1.44
2.2
2.5
91.5
106.7
ug/g
0.37
143
1401
95
1180
0.79
1.42
2.9
2.5
0.7
0.7
ug/l
0.17
66
671
19
111
1.72
1.39
1.6
1.7
271.2
283.3
mosm/kgh2o
0.49
14
88
7
29
2.42
1.39
4.1
2.2
—
—
—
0
0
7
29
2.42
1.39
2.3
1.4
—
—
—
0
0
0
40
0.00
1.32
0.0
2.1
—
78.8
—
0
5
36
250
1.45
1.31
1.9
1.8
—
—
—
0
0
90
722
1.26
1.31
3.8
2.1
—
—
—
0
0
45
327
1.39
1.29
8.4
8.4
1.8
1.7
%
0.60
40
306
45
327
1.39
1.29
8.4
8.4
0.9
0.9
%
0.16
40
306
34
235
1.46
1.28
1.1
1.2
—
—
—
0
0
18
107
1.69
1.26
1.2
1.1
—
—
—
0
0
30
203
1.49
1.25
4.0
3.7
24.7
30.0
mg/l
0.62
25
164
30
203
1.49
1.25
4.0
3.7
34.0
38.8
mg/l
0.31
25
165
44
321
1.38
1.24
1.1
1.4
25.7
23.1
u/l
0.25
35
266
40
547
0.72
1.22
1.3
1.4
—
—
—
0
0
28
188
1.50
1.22
3.5
2.6
—
—
—
0
0
67
524
1.29
1.20
6.2
6.7
—
—
—
0
0
40
544
0.73
1.19
1.3
1.4
—
—
—
0
0
23
149
1.55
1.17
1.5
1.3
—
0.5
nmol/l
—
0
6
15
87
1.73
1.15
1.6
1.4
16.4
28.7
umol/l
1.39
15
82
16
95
1.69
1.14
1.3
3.0
—
—
—
0
0
25
366
0.68
1.13
1.2
1.7
36.3
39.1
nmol/l
0.38
25
356
7
30
2.34
1.12
1.1
1.2
—
—
—
0
0
95
783
1.23
1.12
12.1
7.5
1.2
1.3
mmol/l
0.24
88
758
71
568
1.26
1.09
2.2
2.9
79.6
145.3
ng/l
2.37
63
502
5
21
2.39
1.09
1.4
1.1
—
—
—
0
0
38
279
1.37
1.06
1.2
1.3
345.0
258.1
u/ml
0.53
24
181
12
67
1.80
1.04
1.1
3.3
—
—
—
0
0
246
2728
0.88
1.04
5.1
4.0
14.5
9.3
mg/mmol
0.37
157
1754
91
754
1.22
1.03
4.4
3.5
1.6
1.8
mmol/l
0.31
79
605
10
177
0.56
1.02
1.9
1.6
—
—
—
0
0
43
561
0.76
1.00
1.3
1.5
—
—
—
0
0
9
159
0.56
0.98
1.2
1.4
—
—
—
0
0
0
31
0.00
0.96
0.0
1.1
—
—
—
0
0
59
472
1.26
0.93
2.4
2.2
—
—
—
0
0
25
350
0.71
0.93
1.3
1.4
0.4
0.5
nmol/l
0.10
18
283
633
6018
1.09
0.92
2.8
2.8
97.3
90.0
ug/l
0.37
603
5690
17
110
1.55
0.90
1.1
1.5
11.2
10.4
umol/l
0.22
17
102
81
675
1.21
0.90
4.1
3.8
84.1
79.2
ng/l
0.17
70
607
17
254
0.67
0.89
1.4
1.8
221.6
205.5
pmol/l
0.23
17
243
20
135
1.49
0.89
1.5
1.3
—
—
—
0
0
122
1058
1.17
0.87
2.7
2.4
28.8
39.8
u/l
1.60
106
902
65
789
0.82
0.86
1.6
1.6
316.4
303.9
mu/l
0.08
56
706
33
248
1.34
0.84
1.3
1.4
81.3
104.0
u/ml
—
6
46
111
961
1.17
0.82
11.7
15.5
1.1
1.2
inr
0.56
23
158
283
3069
0.90
0.82
4.3
3.3
7.4
8.0
mmol/l
1.25
231
2653
35
267
1.32
0.81
1.3
1.4
—
—
—
0
0
38
295
1.30
0.79
8.8
9.2
1.2
1.2
mmol/l
0.13
32
254
61
502
1.22
0.78
9.1
9.0
24.3
24.4
mmol/l
0.07
53
470
12
74
1.63
0.78
1.9
2.1
12.0
11.6
%
0.11
12
74
359
3838
0.91
0.77
1.6
1.6
—
—
—
0
0
48
387
1.25
0.75
1.1
1.1
—
—
—
0
0
12
75
1.60
0.75
1.8
1.1
—
—
—
0
0
47
379
1.25
0.73
4.2
2.4
0.7
0.7
%
0.00
47
370
17
242
0.70
0.73
2.1
2.5
46.6
116.0
ug/min
1.04
11
149
231
2119
1.11
0.72
1.5
1.7
—
—
—
0
0
89
767
1.17
0.72
1.5
1.4
—
—
—
0
0
19
134
1.42
0.71
1.4
1.3
—
—
nmol/l
—
0
0
15
101
1.49
0.70
1.1
1.1
—
—
—
0
0
82
706
1.17
0.68
14.6
9.2
—
—
—
0
0
117
1317
0.88
0.67
1.4
1.4
—
—
—
0
0
275
2953
0.92
0.66
1.5
1.6
1.5
1.4
mmol/l
0.57
223
2567
31
394
0.78
0.65
7.1
7.8
—
—
—
0
0
17
120
1.42
0.64
1.1
1.1
—
—
—
0
0
242
2609
0.91
0.64
4.2
3.3
666.2
374.3
mg/l
0.30
152
1685
0
20
0.00
0.60
0.0
1.6
—
—
—
0
0
24
183
1.32
0.59
2.9
3.0
—
—
—
0
0
0
22
0.00
0.59
0.0
2.2
—
1.2
—
0
22
11
72
1.53
0.59
1.4
1.9
—
—
—
0
0
182
1670
1.10
0.59
2.2
2.6
2.4
2.4
mmol/l
0.11
159
1468
55
465
1.19
0.58
3.1
2.6
—
—
—
0
0
15
208
0.72
0.58
2.9
3.4
43.7
23.2
mg/l
—
6
134
43
516
0.83
0.56
1.1
1.3
12.9
10.7
u/l
0.39
35
426
11
73
1.51
0.56
6.0
6.9
—
—
—
0
0
169
1555
1.10
0.53
1.2
1.2
—
—
—
0
0
12
83
1.45
0.52
3.1
1.9
—
—
—
0
0
6
40
1.50
0.51
1.2
1.1
—
—
—
0
0
42
352
1.20
0.50
3.0
3.6
0.4
0.2
g/l
0.65
16
149
6
41
1.47
0.50
1.2
1.3
—
—
—
0
0
1206
11900
1.08
0.50
17.7
11.7
39.9
40.3
%
1.21
901
9655
125
1137
1.11
0.50
1.2
1.2
165.6
143.9
iu/ml
0.25
48
447
56
646
0.86
0.49
1.1
1.1
—
—
—
0
0
58
503
1.16
0.48
1.2
1.2
—
—
—
0
0
87
777
1.13
0.48
1.3
1.2
—
—
—
0
0
41
347
1.19
0.46
4.6
2.9
—
—
—
0
0
11
78
1.41
0.43
1.1
1.1
—
—
—
0
0
14
184
0.76
0.42
1.4
1.6
—
—
—
0
0
8
58
1.38
0.41
1.8
2.9
1736.2
1989.2
ml
—
8
53
0
15
0.00
0.41
0.0
1.0
—
0.3
—
0
7
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
136
1258
1.09
0.41
1.4
1.3
—
—
—
0
0
11
79
1.40
0.40
3.0
2.4
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
5
34
1.47
0.40
1.2
1.1
—
—
—
0
0
36
307
1.18
0.38
1.1
1.1
—
—
—
0
0
73
810
0.90
0.38
3.3
4.4
6.1
18.6
ug/l
0.88
54
624
12
89
1.35
0.38
1.0
1.6
—
—
—
0
0
42
364
1.16
0.37
1.8
2.0
8.2
4.6
iu/l
0.57
13
137
6
42
1.43
0.35
1.0
1.1
—
—
—
0
0
6
42
1.43
0.35
2.5
1.2
—
—
—
0
0
29
245
1.19
0.35
2.1
1.5
—
—
—
0
0
19
154
1.24
0.34
4.8
4.2
—
—
—
0
0
98
905
1.09
0.32
3.1
3.3
4.4
4.6
pmol/l
1.41
84
811
60
542
1.11
0.31
6.0
2.9
—
—
—
0
0
32
278
1.15
0.29
1.7
1.7
—
—
—
0
0
7
56
1.25
0.29
1.1
1.1
484.2
161.5
iu/ml
—
7
56
17
206
0.82
0.29
5.8
3.3
—
—
—
0
0
35
307
1.14
0.29
1.1
1.1
—
—
—
0
0
8
64
1.25
0.27
1.1
1.1
4.9
6.5
mmol/l
—
8
57
16
131
1.22
0.27
1.3
1.8
—
—
—
0
0
27
236
1.15
0.24
1.2
1.2
—
—
—
0
0
5
38
1.32
0.23
7.2
3.8
—
—
—
0
0
568
5574
1.03
0.22
3.7
3.9
—
—
—
0
0
5
41
1.22
0.22
5.2
1.4
—
—
—
0
0
5
42
1.19
0.21
1.8
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
2.5
—
39.3
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
2.2
—
1.2
—
0
7
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
5
43
1.16
0.21
1.0
1.0
—
—
—
0
0
5
43
1.16
0.21
1.0
1.1
—
—
—
0
0
6
49
1.23
0.20
1.3
2.1
—
—
—
0
0
6
51
1.18
0.19
1.7
1.7
—
—
—
0
0
6
53
1.13
0.18
1.5
1.8
—
—
—
0
0
58
620
0.93
0.17
4.7
2.2
—
—
—
0
0
7
61
1.15
0.17
1.3
1.5
—
—
—
0
0
70
741
0.94
0.16
1.9
2.1
12.1
12.5
nmol/l
0.15
63
675
28
254
1.10
0.16
1.1
1.1
—
—
—
0
0
27
297
0.91
0.15
1.9
3.4
1.3
1.4
mg/l
0.46
21
277
1152
11452
1.03
0.15
3.8
3.7
5.7
5.7
mmol/l
1.86
1056
10743
27
245
1.10
0.15
1.1
1.0
1.6
2.2
u/ml
0.40
12
125
24
217
1.11
0.14
1.0
1.1
1.1
2238.9
iu/ml
—
7
58
10
84
1.19
0.14
1.2
1.5
5.5
6.0
mmol/l
—
10
60
8
96
0.83
0.13
1.0
1.4
—
—
—
0
0
61
642
0.95
0.13
1.8
2.2
7.3
6.9
ug/l
0.06
52
579
203
1983
1.03
0.12
4.1
3.9
1.6
1.9
ug/l
0.92
174
1812
74
772
0.96
0.12
4.1
2.1
—
—
—
0
0
16
143
1.12
0.11
1.6
1.4
—
—
—
0
0
16
143
1.12
0.11
1.6
1.4
—
—
—
0
0
16
143
1.12
0.11
1.6
1.4
—
—
—
0
0
16
143
1.12
0.11
1.6
1.4
—
—
—
0
0
14
124
1.13
0.11
1.3
1.6
62.3
53.5
%
—
8
86
5
46
1.09
0.09
1.4
1.4
—
—
—
0
0
6
58
1.03
0.08
1.3
1.4
—
—
—
0
0
36
379
0.95
0.08
1.2
1.2
—
—
—
0
0
34
322
1.06
0.08
1.4
1.3
—
—
—
0
0
5
65
0.77
0.08
1.0
1.1
—
—
—
0
0
6
72
0.83
0.07
1.2
1.3
—
—
—
0
0
6
74
0.81
0.07
1.7
2.1
1154.8
612.9
ml
—
6
48
55
530
1.04
0.07
1.6
1.6
—
—
—
0
0
355
3588
0.99
0.07
2.2
2.1
—
—
—
0
0
7
80
0.87
0.07
1.1
1.2
—
—
—
0
0
13
118
1.10
0.07
1.2
1.8
20.6
19.7
nmol/l
0.22
13
111
62
640
0.97
0.07
1.1
1.1
—
—
—
0
0
76
781
0.97
0.06
4.1
2.1
—
—
—
0
0
9
102
0.88
0.06
1.9
2.0
32.9
32.4
pg
—
9
102
231
2281
1.02
0.06
1.3
1.3
3.5
10.4
u/ml
3.55
83
959
17
158
1.08
0.06
2.8
2.8
7.6
7.2
mmol/l
0.44
17
153
164
1665
0.98
0.06
1.7
1.9
—
—
—
0
0
11
121
0.91
0.06
1.1
1.1
—
—
—
0
0
10
90
1.11
0.05
2.5
2.4
—
—
—
0
0
76
778
0.98
0.05
4.0
2.1
—
—
—
0
0
75
766
0.98
0.04
3.7
2.1
—
—
—
0
0
29
302
0.96
0.04
1.2
1.2
—
—
—
0
0
270
2678
1.01
0.04
2.2
2.1
—
—
—
0
0
18
170
1.06
0.04
2.8
2.7
1.7
1.5
mmol/l
0.27
18
163
36
372
0.97
0.04
1.2
1.5
59.2
115.6
pmol/l
1.03
36
366
10
92
1.09
0.03
1.7
1.3
—
62.6
—
0
12
33
320
1.03
0.03
6.7
4.6
—
—
—
0
0
21
201
1.05
0.03
2.9
2.4
—
—
—
0
0
11
102
1.08
0.03
1.0
1.2
—
—
—
0
0
1059
10573
1.01
0.02
4.5
4.6
37.5
38.5
mmol/mol
3.08
976
10024
279
2804
0.99
0.02
2.4
2.3
3073.2
4122.4
umol/l
0.26
246
2494
83
820
1.01
0.02
1.2
1.2
—
—
—
0
0
10
93
1.08
0.02
2.5
2.4
4.2
4.0
mmol/l
—
10
93
10
93
1.08
0.02
2.5
2.4
103.3
105.5
mmol/l
—
10
93
73
721
1.01
0.01
4.1
2.2
—
—
—
0
0
26
253
1.03
0.01
1.0
1.1
—
—
—
0
0
32
313
1.02
0.01
1.5
1.4
313.7
306.5
ug/g
0.06
17
172
18
174
1.03
0.00
1.2
1.3
—
—
—
0
0
20
194
1.03
0.00
2.5
2.5
—
—
—
0
0
10
104
0.96
0.00
1.0
1.0
—
—
—
0
0
11
114
0.96
0.00
1.2
1.1
—
—
—
0
0
11
111
0.99
0.00
1.2
1.5
0.9
1.0
g/l
0.23
11
111
14
139
1.01
0.00
1.5
1.5
—
—
—
0
0
149
1492
1.00
0.00
1.3
1.2
—
—
—
0
0
14
137
1.02
0.00
3.4
2.1
—
—
—
0
0
91
907
1.00
0.00
1.2
1.4
—
—
—
0
0
11
105
1.05
0.00
3.2
3.3
16.6
64.3
u/ml
1.72
11
105
10
105
0.95
0.00
1.0
1.2
—
—
—
0
0
7
77
0.91
0.00
2.3
2.6
—
—
—
0
0
5
56
0.89
0.00
2.0
2.5
60.2
50.3
umol/l
—
5
49
8
80
1.00
0.00
1.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.0
—
136.2
—
0
9
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
6.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
5
57
0.88
0.00
1.2
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
9
93
0.97
0.00
3.6
7.1
6.9
7.2
mmol/l
—
9
74
0
5
0.00
0.00
0.0
2.4
—
197.4
—
0
5
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint G6_OTHDEMYEL and mortality.

Females

Parameter HR [95% CI] p-value
G6_OTHDEMYEL 2.092 [1.77, 2.47] < 0.001
Birth year 0.994 [0.98, 1.0] 0.142

During the follow-up period (1.1.1998 — 31.12.2019), 246 out of 4099 females with G6_OTHDEMYEL died.

Males

Parameter HR [95% CI] p-value
G6_OTHDEMYEL 2.444 [2.08, 2.87] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 304 out of 2166 males with G6_OTHDEMYEL died.

Mortality risk

Mortality risk for people of age

years, who have G6_OTHDEMYEL.

N-year risk Females Males
1 0.224% 0.37%
5 1.238% 2.478%
10 2.828% 5.803%
15 5.52% 11.151%
20 9.909% 18.746%

Relationships between endpoints

Index endpoint: G6_OTHDEMYEL – Other demyelinating diseases of the central nervous system

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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