No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2477 |
4. Check minimum number of eventsNone |
2477 |
5. Include endpointsNone |
2477 |
6. Filter based on genotype QC (FinnGen only) |
2477 |
Control definitions (FinnGen only)
- Control exclude
- H7_OCUMUSCLE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H50
- Name in latin
- Strabismus convergens concomitans
Similar endpoints
↥List of similar endpoints to
Convergent concomitant strabismus
based on the number of shared cases.
Similar with more cases:
- Other strabismus
- Strabismus
- Disorders of ocular muscles, binocular movement, accommodation and refraction
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 31953 | 16397 | 15488 |
| Only index persons | 27242 | 14182 | 13060 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.45 | 0.47 | 0.43 |
| Only index persons | 0.51 | 0.52 | 0.50 |
| Median age at first event (years) | |||
| Whole population | 6.21 | 6.47 | 5.83 |
| Only index persons | 6.67 | 7.01 | 6.31 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2477 | 1591 | 886 |
| Unadjusted period prevalence (%) | 0.49 | 0.54 | 0.39 |
| Median age at first event (years) | 9.92 | 10.03 | 9.74 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 2230
- Matched controls
- 22300
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H50.0
ICD-10 Finland
Convergent concomitant strabismus
+∞
323.0
1071
*
37300
ICD-8 Finland
Strabismus, Concomitans convergens
+∞
323.0
972
*
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
+∞
316.4
296
*
H50.30
ICD-10 Finland
Intermittent esotropy
1255.2
235.7
226
*
3780A
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Convergent concomitant strabismus[STRABISMUS CONCOMITANS CONVERGENS]
+∞
224.9
212
*
3503
FHL
Single muscle retroposition
+∞
209.8
198
*
3780B
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Convergent concomitant strabismus[STRABISMUS CONVERGENS ALTERNANS]
+∞
179.6
170
*
CEC00
NOMESCO Finland
Recession of extraocular muscle
1894.4
175.3
168
*
H53.0
ICD-10 Finland
Amblyopia ex anopsia
58.1
154.1
182
34
H50.1
ICD-10 Finland
Divergent concomitant strabismus
750.3
144.7
141
*
H50.2
ICD-10 Finland
Vertical strabismus
1390.4
135.9
131
*
H52.0
ICD-10 Finland
Hypermetropia
53.9
126.3
151
30
3507
FHL
Retroposition and resection
+∞
112.4
107
*
H50.31
ICD-10 Finland
Intermittent exotropia
1012.3
99.9
97
*
H53.2
ICD-10 Finland
Diplopia
16.3
95.6
158
104
H50.51
ICD-10 Finland
Esophoria
482.5
94.0
93
*
37301
ICD-8 Finland
Strabismus, Concomitans divergens
+∞
90.2
86
*
37720
ICD-8 Finland
Other diseases of retina and optic nerve, Amblyopia
311.1
88.4
89
*
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
+∞
68.1
65
*
CEC30
NOMESCO Finland
Resection of extraocular muscle
+∞
66.0
63
*
3504
FHL
Retroposition of two muscles
+∞
61.7
59
*
CEW99
NOMESCO Finland
Other operation on extraocular muscle
+∞
57.5
55
*
CEC60
NOMESCO Finland
Transposition of extraocular muscle with adjustable suture
+∞
54.4
52
*
H50.9
ICD-10 Finland
Strabismus, unspecified
77.2
53.2
60
8
3505
FHL
Single muscle resection
+∞
52.3
50
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.4
49.6
260
827
H50.52
ICD-10 Finland
Exophoria
88.8
47.0
52
6
37302
ICD-8 Finland
Strabismus, Concomitans sursum sive deorsum vergens
+∞
42.8
41
*
H52.2
ICD-10 Finland
Astigmatism
23.2
42.4
61
27
H52.1
ICD-10 Finland
Myopia
8.0
42.3
98
127
37001
ICD-8 Finland
Refractive errors, Hypermetropia. Hyperopia
+∞
41.8
40
*
H50.8
ICD-10 Finland
Other specified strabismus
404.6
40.2
40
*
37303
ICD-8 Finland
Strabismus, Heterophoria (exophoria, esophroria, hypophoria)
+∞
38.6
37
*
H52.3
ICD-10 Finland
Anisometropia and aniseikonia
62.6
37.2
43
7
3680A
ICD-9 Finland
Visual disturbances, Amblyopia ex anopsia
331.8
33.0
33
*
H55
ICD-10 Finland
Nystagmus and other irregular eye movements
32.9
32.2
42
13
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.2
30.7
358
1798
CEC20
NOMESCO Finland
Recession and advancement of extraocular muscle
+∞
30.3
29
*
CEC50
NOMESCO Finland
Advancement of extraocular muscle
+∞
29.2
28
*
3510
FHL
Cardiac surgery on three or more muscles
+∞
29.2
28
*
37929
ICD-8 Finland
Blindness, one eye, specifically defined
295.7
28.8
29
*
3783A
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Other and unspecified heterotropia
+∞
28.2
27
*
WX140
NOMESCO Finland
Parabulbar anesthesy
5.0
27.2
89
183
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.7
25.2
689
4653
3781A
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Divergent concomitant strabismus[STRABISMUS CONCOMITANS DIVERGENS]
+∞
25.0
24
*
3508
FHL
Transposition or anteposition
+∞
23.0
22
*
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
16.6
22.7
36
22
H50.6
ICD-10 Finland
Mechanical strabismus
+∞
20.9
20
*
3781B
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Divergent concomitant strabismus[STRABISMUS DIVERGENS ALTERNANS]
+∞
20.9
20
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.2
20.0
221
1072
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
18.8
523
3498
F83
ICD-10 Finland
Mixed specific developmental disorders
7.0
18.7
46
67
G80.1
ICD-10 Finland
Spastic diplegic cerebral palsy
38.7
18.6
23
6
CE2W4
NOMESCO Finland
Eye movement mapping
67.1
17.7
20
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.6
17.4
508
3431
XCK00
NOMESCO Finland
Perimetry
2.8
17.4
115
427
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
16.1
17.0
27
17
H49.1
ICD-10 Finland
Fourth [trochlear] nerve palsy
+∞
16.7
16
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.5
16.6
132
545
H50.4
ICD-10 Finland
Other and unspecified heterotropia
90.8
16.6
18
*
37309
ICD-8 Finland
Strabismus, Unspecified
+∞
15.6
15
*
3782B
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Intermittent heterotropia[STRABISMUS DIVERGENS INTERMITTENS]
+∞
15.6
15
*
3780X
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Convergent concomitant strabismus[STRABISMUS CONVERGENS ALIUS]
+∞
15.6
15
*
ZXA05
NOMESCO Finland
Left side
1.7
15.6
399
2593
ZXA10
NOMESCO Finland
Bilateral
1.7
14.6
307
1882
3671A
ICD-9 Finland
Disorders of refraction and accommodation, Myopia
+∞
14.6
14
*
3670A
ICD-9 Finland
Disorders of refraction and accommodation, Hypermetropia
+∞
14.6
14
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
3.1
14.4
78
255
S01FA01
ATC
atropine; ophthalmic
15.5
14.4
23
15
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
8.3
14.3
31
38
F95
ICPC
Strabismus
75.6
13.6
15
*
37000
ICD-8 Finland
Refractive errors, Astigmatismus
+∞
13.6
13
*
CEC90
NOMESCO Finland
Total transposition of extraocular muscle or muscles
140.8
13.5
14
*
R62.0
ICD-10 Finland
Delayed milestone
5.5
13.4
39
72
H54.5
ICD-10 Finland
Severe visual impairment, monocular
16.8
13.0
20
12
XCD00
NOMESCO Finland
Clinical examination of eye in general anaesthesia
50.3
12.8
15
*
F82
ICD-10 Finland
Specific developmental disorder of motor function
6.8
12.7
31
46
3501
FHL
Myotomy or tenotomy
+∞
12.5
12
*
H50
ICD-10 Finland
Other strabismus
+∞
12.5
12
*
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
11.7
12.3
22
19
ZXA00
NOMESCO Finland
Right side
1.5
12.3
405
2795
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.2
12.2
125
585
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.0
12.2
160
833
3519
FHL
Other measure in this category
+∞
11.5
11
*
34301
ICD-8 Finland
Cerebral spastic infantile paralysis, Diplegia spastica
+∞
11.5
11
*
P85
ICPC
Mental retardation
12.8
11.1
19
15
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.1
11.0
124
610
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.2
10.9
106
487
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
1.9
10.7
161
884
3430A
ICD-9 Finland
Infantile cerebral palsy, Diplegic
60.3
10.6
12
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.1
10.6
121
599
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
+∞
10.4
10
*
H50.3
ICD-10 Finland
Intermittent heterotropia
+∞
10.4
10
*
37304
ICD-8 Finland
Strabismus, paralyticus. Paresis nervorum III, IV, VI
+∞
10.4
10
*
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
13.2
10.2
17
13
Z3229
NOMESCO Finland
Other healthcare associate professional
1.9
10.1
150
817
ZXE10
NOMESCO Finland
More than one and less than three hours
1.4
10.1
606
4701
Z3231
NOMESCO Finland
Registered nurse
1.4
9.9
491
3672
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.2
9.6
93
429
WX110
NOMESCO Finland
Local anesthesy
1.3
9.4
1454
13020
CAC44
NOMESCO Finland
Combined decompression of orbit
100.4
9.4
10
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.5
9.4
381
2735
WX002
NOMESCO Finland
Sedation and analgesia
1.5
9.4
297
2018
3784B
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Heterophoria[EXOPHORIA]
+∞
9.4
9
*
37003
ICD-8 Finland
Refractive errors, Anisometropia
+∞
9.4
9
*
CAC30
NOMESCO Finland
Decompression of orbit to sinuses
+∞
9.4
9
*
H51.8
ICD-10 Finland
Other specified disorders of binocular movement
+∞
9.4
9
*
H26.4
ICD-10 Finland
After-cataract
2.3
9.4
86
387
H52.5
ICD-10 Finland
Disorders of accommodation
50.2
8.7
10
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.6
8.5
238
1572
Q12.0
ICD-10 Finland
Congenital cataract
27.6
8.5
11
*
CEC40
NOMESCO Finland
Resection and advancement of extraocular muscle
+∞
8.3
8
*
3782A
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Intermittent heterotropia[STRABISMUS CONVERGENS INTERMITTENS]
+∞
8.3
8
*
37002
ICD-8 Finland
Refractive errors, Myopia
+∞
8.3
8
*
ZXD20
NOMESCO Finland
Day surgery
1.6
8.3
231
1522
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
2.5
8.2
61
249
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
5.7
8.1
22
39
G80.2
ICD-10 Finland
Spastic hemiplegic cerebral palsy
17.2
8.1
12
7
G40.9
ICD-10 Finland
Epilepsy, unspecified
2.5
8.0
62
256
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
7.2
8.0
18
25
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.7
7.8
147
870
H50.50
ICD-10 Finland
Alternating hyperphoria
45.1
7.7
9
*
H51.1
ICD-10 Finland
Convergence insufficiency and excess
45.1
7.7
9
*
H03AA01
ATC
levothyroxine sodium; systemic
1.4
7.7
367
2714
CS494
NOMESCO Finland
Other visual field testing
3.3
7.7
37
115
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
1.9
7.6
101
533
TAB00
NOMESCO Finland
Lumbar puncture
2.0
7.5
87
435
ZXE00
NOMESCO Finland
One hour or less
1.3
7.5
717
5932
WX402
NOMESCO Finland
General anaesthesia
1.5
7.3
302
2173
XCD10
NOMESCO Finland
Electrophysiological examination of eye
2.9
7.3
42
147
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
3.6
7.3
30
83
H52.4
ICD-10 Finland
Presbyopia
3.2
7.2
36
115
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.6
7.2
206
1368
G80.0
ICD-10 Finland
Spastic quadriplegic cerebral palsy
30.1
7.1
9
*
G80.9
ICD-10 Finland
Cerebral palsy, unspecified
20.1
7.1
10
5
TPH04
NOMESCO Finland
Cathetrisation of vein
1.4
7.1
322
2362
Z01.8
ICD-10 Finland
Other specified special examinations
1.4
6.9
349
2604
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
2.7
6.9
45
170
H53.4
ICD-10 Finland
Visual field defects
3.2
6.8
34
109
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
2.8
6.8
41
150
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.5
6.8
224
1537
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.5
6.7
214
1456
N03AG01
ATC
valproic acid; systemic, rectal
1.8
6.5
113
656
N05AH03
ATC
olanzapine; systemic
1.7
6.5
121
718
CJB10
NOMESCO Finland
Laser discission of secondary cataract
2.1
6.5
71
351
R56.8
ICD-10 Finland
Other and unspecified convulsions
1.8
6.4
99
553
H50.39
ICD-10 Finland
Intermittent heterotropia
70.0
6.4
7
*
3699X
ICD-9 Finland
Blindness and low vision, Unspecified visual loss
+∞
6.3
6
*
XCW11
NOMESCO Finland
Assessment of strabismus
+∞
6.3
6
*
CEC80
NOMESCO Finland
Partial transposition of extraocular muscle
+∞
6.3
6
*
3795A
ICD-9 Finland
Other disorders of eye, Nystagmus and other irregular eye movements
+∞
6.3
6
*
3768
FHL
Eye examination under general anesthesia
26.7
6.2
8
*
WX400
NOMESCO Finland
Inhalation anesthesy
1.9
6.2
89
484
S01FA04
ATC
cyclopentolate; ophthalmic
3.9
6.2
23
59
H05.2
ICD-10 Finland
Exophthalmic conditions
12.5
6.1
10
8
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
10.0
6.0
11
11
Mortality – FinRegistry
↥Association
Association between endpoint H7_CONVERSTRAB and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CONVERSTRAB | 1.266 [1.03, 1.56] | 0.027 |
| Birth year | 0.993 [0.98, 1.0] | 0.115 |
During the follow-up period (1.1.1998 — 31.12.2019), 231 out of 8389 females with H7_CONVERSTRAB died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CONVERSTRAB | 1.261 [1.02, 1.56] | 0.03 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 237 out of 7962 males with H7_CONVERSTRAB died.
Mortality risk
Mortality risk for people of age
years, who have H7_CONVERSTRAB.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.12% | 0.25% |
| 5 | 0.741% | 1.622% |
| 10 | 1.733% | 3.733% |
| 15 | 3.213% | 7.03% |
| 20 | 5.683% | 11.43% |
Relationships between endpoints
↥Index endpoint: H7_CONVERSTRAB – Convergent concomitant strabismus
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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