Other specified and unspecified disorders of eye and adnexa

H7_EYEADNEXOTH

eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H57.8, H57.9
  • Hospital discharge: ICD-9 379[8-9]
  • Hospital discharge: ICD-8 37898
  • Cause of death: ICD-10 H57.8, H57.9
  • Cause of death: ICD-9 379[8-9]
  • Cause of death: ICD-8 37898

2 out of 7 registries used, show all original rules.

1475

4. Check minimum number of events

None

1475

5. Include endpoints

None

1475

6. Filter based on genotype QC (FinnGen only)

1475

Control definitions (FinnGen only)

Control exclude
H7_EYEOTH

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 12111 7188 4811
Only index persons 9719 5826 3893
Unadjusted period prevalence (%)
Whole population 0.18 0.21 0.13
Only index persons 0.19 0.21 0.15
Median age at first event (years)
Whole population 47.98 51.02 43.22
Only index persons 43.84 47.44 38.46

-FinnGen-

Key figures

All Female Male
Number of individuals 1475 943 532
Unadjusted period prevalence (%) 0.29 0.32 0.23
Median age at first event (years) 48.25 47.13 50.23

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1320
Matched controls
13199
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H57.9
ICD-10 Finland
Disorder of eye and adnexa, unspecified
4642.9
323.0
1013
9
37898
ICD-8 Finland
Other diseases of eye, Disease of eyeball, ocular muscle and orbit NEC
+∞
237.9
221
*
Z2221
NOMESCO Finland
Medical doctor
5.6
177.6
732
2399
Z3231
NOMESCO Finland
Registered nurse
4.4
125.7
630
2279
ZXD10
NOMESCO Finland
Scheduled procedure
3.9
119.0
785
3582
R4110
NOMESCO Finland
Physiotherapy
4.0
107.0
581
2177
Z3226
NOMESCO Finland
Physiotherapist
4.3
97.1
446
1410
ZXE00
NOMESCO Finland
One hour or less
3.3
92.6
750
3733
XCK10
NOMESCO Finland
Photography of fundus of eye
5.3
87.0
298
686
H57.8
ICD-10 Finland
Other specified disorders of eye and adnexa
296.0
82.6
83
*
XCK00
NOMESCO Finland
Perimetry
6.7
81.9
227
399
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.8
79.5
301
766
ZXE10
NOMESCO Finland
More than one and less than three hours
3.0
76.4
661
3286
XF400
NOMESCO Finland
ECG with 12 standard connections
3.5
62.1
347
1223
ZXA00
NOMESCO Finland
Right side
2.7
52.9
473
2253
WX002
NOMESCO Finland
Sedation and analgesia
3.0
50.9
367
1523
H57.1
ICD-10 Finland
Ocular pain
11.6
49.4
94
87
XCD10
NOMESCO Finland
Electrophysiological examination of eye
9.7
49.3
103
114
ZXA05
NOMESCO Finland
Left side
2.7
49.1
444
2107
ZXD20
NOMESCO Finland
Day surgery
3.3
48.5
285
1022
Z3229
NOMESCO Finland
Other healthcare associate professional
4.0
46.8
207
588
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.3
44.7
631
3741
Z2446
NOMESCO Finland
Social worker
4.6
43.3
162
391
H04.10
ICD-10 Finland
Dry eye syndrome
3.5
41.8
213
679
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.6
38.3
188
579
ZXA10
NOMESCO Finland
Bilateral
2.6
36.8
329
1511
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.7
36.2
282
1195
H53.1
ICD-10 Finland
Subjective visual disturbances
4.3
34.0
134
339
H02AB07
ATC
prednisone; oral
2.7
32.7
260
1108
XA800
NOMESCO Finland
Neuropsychological investigation
5.7
32.3
96
179
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
4.2
31.9
129
334
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.5
30.7
279
1279
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.3
29.7
333
1693
S01GX01
ATC
cromoglicic acid; ophthalmic
2.3
29.5
311
1534
Z2445
NOMESCO Finland
Psychologist
5.5
29.4
90
174
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
29.3
407
2279
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
2.2
28.2
363
1961
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
27.8
419
2420
R4120
NOMESCO Finland
Occupational therapy
3.8
26.4
119
339
R51.80
ICD-10 Finland
Headache
2.5
26.2
234
1052
N02AX02
ATC
tramadol; systemic, rectal
1.9
26.1
580
3863
Z71.8
ICD-10 Finland
Other specified counselling
2.1
25.8
338
1828
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.9
24.1
497
3194
H46
ICD-10 Finland
Optic neuritis
17.6
23.2
36
21
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
5.5
22.0
66
125
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
21.8
237
1170
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
3.6
20.9
96
278
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.5
20.6
174
752
EB1AA
SPAT
NA
3.6
20.4
95
278
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
4.3
20.4
78
192
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.6
19.8
158
664
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
3.4
19.4
99
311
N03AX16
ATC
pregabalin; oral
1.9
19.4
326
1916
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
19.4
287
1608
ZXD05
NOMESCO Finland
Urgent procedure
1.8
19.1
427
2769
SPAT1324
SPAT
Screening procedure
0.3
19.0
43
1334
WX140
NOMESCO Finland
Parabulbar anesthesy
3.7
18.9
85
242
XCD20
NOMESCO Finland
Photoangiography of eye
6.0
18.9
52
89
R07.4
ICD-10 Finland
Chest pain, unspecified
1.8
18.7
366
2267
J01DA01
ATC
[U] cefalexin; systemic
1.7
18.6
830
6593
J01MA02
ATC
ciprofloxacin; systemic
1.7
18.5
506
3485
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
3.0
18.2
109
384
H02.4
ICD-10 Finland
Ptosis of eyelid
4.8
18.1
61
132
A02BA02
ATC
ranitidine; systemic
1.9
17.8
282
1614
J01DA06
ATC
[U] cefuroxime; systemic
2.1
17.7
224
1174
WX110
NOMESCO Finland
Local anesthesy
1.7
17.6
865
7004
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
3.0
17.4
104
365
WX892
NOMESCO Finland
Monitored bed care
2.8
17.4
117
443
S01EA03
ATC
apraclonidine; ophthalmic
8.3
17.3
38
47
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
4.5
17.2
61
140
M79.6
ICD-10 Finland
Pain in limb
1.7
17.1
460
3134
A02BC05
ATC
esomeprazole; systemic
1.7
17.1
522
3695
N06AB04
ATC
citalopram; systemic
1.9
16.9
297
1764
H26.2
ICD-10 Finland
Complicated cataract
8.0
16.9
38
49
TAB00
NOMESCO Finland
Lumbar puncture
3.5
16.8
79
234
A02BC02
ATC
pantoprazole; systemic
1.6
16.7
829
6679
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
4.0
16.6
67
174
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.3
16.5
168
797
ZXD35
NOMESCO Finland
Usual procedure
3.8
16.4
70
191
J01FA06
ATC
roxithromycin; oral
1.7
16.4
528
3779
R03AC02
ATC
salbutamol; inhalant
1.6
16.3
676
5176
J05AB11
ATC
valaciclovir; oral
2.2
16.3
185
924
H43.8
ICD-10 Finland
Other disorders of vitreous body
2.5
16.3
129
540
TKC20
NOMESCO Finland
Catheterisation of bladder
2.7
16.3
114
442
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
3.6
16.0
72
206
X59
ICD-10 Finland
Exposure to unspecified factor
2.0
15.9
240
1345
AA1AD
NOMESCO Finland
CT of head and brain
1.8
15.9
300
1823
UJF30
NOMESCO Finland
Ileoscopy through colon
2.4
15.8
144
646
XF600
NOMESCO Finland
Bloodpressure measurement
2.8
15.6
105
399
R42
ICD-10 Finland
Dizziness and giddiness
1.8
15.5
295
1793
A11
ICPC
Chest pain NOS
2.5
15.5
126
534
ZY010
NOMESCO Finland
Hospital outpatient
3.2
15.1
81
266
Z76.0
ICD-10 Finland
Issue of repeat prescription
2.0
15.0
208
1126
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
25.3
14.7
20
8
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.1
14.7
172
870
RD210
NOMESCO Finland
NA
5.9
14.6
40
69
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.1
14.5
80
267
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
14.5
532
3904
R01AD09
ATC
mometasone; nasal
1.6
14.5
562
4181
N05CF01
ATC
zopiclone; oral
1.7
14.4
423
2926
H25.1
ICD-10 Finland
Senile nuclear cataract
1.7
14.2
315
2005
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
3.2
14.2
76
249
M03BC01
ATC
orphenadrine (citrate); systemic
1.8
14.2
307
1938
XF402
NOMESCO Finland
ECG with work load test
2.2
14.1
155
763
Z01.7
ICD-10 Finland
Laboratory examination
2.1
14.0
163
820
R03BA02
ATC
budesonide; inhalant
1.9
13.9
242
1424
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
13.8
286
1779
H53.2
ICD-10 Finland
Diplopia
3.8
13.8
58
157
J01FA10
ATC
azithromycin; systemic
1.6
13.7
729
5829
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.6
13.6
99
394
A06AC01
ATC
ispaghula (psylla seeds); oral
1.7
13.5
319
2062
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.2
13.5
149
732
S01AA01
ATC
chloramphenicol; ophthalmic (antibiotics)
2.8
13.5
87
321
H02AB06
ATC
prednisolone; systemic
1.6
13.5
580
4400
SPAT1263
SPAT
Sampling
0.6
13.5
270
3978
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
11.6
13.3
24
21
R53
ICD-10 Finland
Malaise and fatigue
1.8
13.2
268
1657
UJH02
NOMESCO Finland
Anoscopy
3.0
13.1
76
263
WX402
NOMESCO Finland
General anaesthesia
1.9
13.0
216
1247
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
2.8
13.0
85
318
R06AX27
ATC
desloratadine; oral
1.7
12.9
339
2258
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.3
12.9
126
587
CG2T4
NOMESCO Finland
Topography assessment of cornea
8.6
12.8
27
32
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.6
12.6
528
3960
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
3.4
12.6
61
186
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
4.6
12.6
43
96
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.3
12.6
117
532
M01AE03
ATC
ketoprofen; systemic, rectal
1.6
12.6
472
3447
J01DB01
ATC
cefalexin; oral
1.6
12.6
1022
8959
S21
ICPC
Skin texture symptom/complaint
2.0
12.3
161
849
R4190
NOMESCO Finland
Nutritional therapy
3.8
12.3
51
137
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
12.3
220
1300
CS1H4
NOMESCO Finland
Retinal nerve fibre layer imaging
5.6
12.3
35
64
H53.9
ICD-10 Finland
Visual disturbance, unspecified
3.8
12.2
51
138
SPAT1336
SPAT
Request for examination
3.1
12.1
65
214
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
5.5
12.1
35
65
N30
ICD-10 Finland
Cystitis
2.3
12.1
115
526
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
2.1
12.0
149
769
P01AB01
ATC
metronidazole; oral, rectal
1.6
12.0
487
3614
XX9XE
NOMESCO Finland
Other ultrasound examination
8.8
12.0
25
29
N05BA01
ATC
diazepam; systemic, rectal
1.9
11.9
179
995
ZXE20
NOMESCO Finland
More than three and less than five hours
1.9
11.9
177
983
B01AB04
ATC
dalteparin; parenteral
2.8
11.8
74
271
WX110
SPAT
NA
2.9
11.8
72
257
C07AB07
ATC
bisoprolol; oral
1.5
11.8
558
4289
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
4.7
11.7
39
85
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
6.4
11.7
30
48
XCH05
NOMESCO Finland
Eye pressure longterm registration
6.4
11.7
30
48
J01AA02
ATC
doxycycline; systemic
1.6
11.7
979
8538
J02AC01
ATC
fluconazole; systemic
1.5
11.7
513
3872
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
4.6
11.7
40
90
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.6
11.6
425
3071
S29
ICPC
Skin symptom/complaint other
1.8
11.6
208
1229
XF404
NOMESCO Finland
Ambulatory ECG
2.2
11.6
127
622
F29
ICPC
Eye symptom/complaint other
2.3
11.5
109
498
L17
ICPC
Foot/toe symptom/complaint
1.6
11.5
313
2099
Z03
ICD-10 Finland
Medical observation and evaluation for suspected diseases and conditions, ruled out
2.2
11.5
116
546
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.1
11.5
139
712
G81.9
ICD-10 Finland
Hemiplegia, unspecified
7.6
11.5
26
35
IGY02
NOMESCO Finland
Psychiatric monitoring contact
4.8
11.4
37
79
A02BC01
ATC
omeprazole; systemic
1.6
11.4
346
2387
C01CA24
ATC
epinephrine; parenteral
2.5
11.4
89
370
H40.0
ICD-10 Finland
Glaucoma suspect
2.3
11.3
101
450
J31.0
ICD-10 Finland
Chronic rhinitis
2.3
11.2
110
512
D01
ICPC
Abdominal pain/cramps general
2.0
11.1
140
725
Z31.5
ICD-10 Finland
Genetic counselling
2.7
11.1
75
288
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
4.4
11.0
39
91
R05
ICD-10 Finland
Cough
1.7
11.0
244
1543
RS222
NOMESCO Finland
NA
5.3
10.9
32
61
ZXC20
NOMESCO Finland
Use of chemical agents
4.3
10.9
39
92
Z01.6
ICD-10 Finland
Radiological examination, not elsewhere classified
2.1
10.9
132
672
U13
ICPC
Bladder symptom/complaint other
3.2
10.8
57
186
Z11.3
ICD-10 Finland
Special screening examination for infections with a predominantly sexual mode of transmission
2.7
10.8
75
292
R07.0
ICD-10 Finland
Pain in throat
2.4
10.7
88
376
TNX99
NOMESCO Finland
Other orthopaedic minor procedure
3.5
10.7
48
139
R20.2
ICD-10 Finland
Paraesthesia of skin
2.4
10.7
90
389
G35
ICD-10 Finland
Multiple sclerosis
5.2
10.6
32
63
E0000UV
ATC
NA
1.5
10.6
467
3507
R03DC03
ATC
montelukast; oral
1.8
10.6
204
1231
H52.1
ICD-10 Finland
Myopia
3.3
10.6
53
167
S01ED01
ATC
timolol; ophthalmic
2.9
10.6
62
218
N01
ICPC
Headache
2.0
10.5
135
705
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
2.5
10.4
78
318
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.9
10.4
154
849
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
2.9
10.4
61
215
N17
ICPC
Vertigo/dizziness
2.0
10.4
146
791
D11
ICPC
Diarrhoea
1.9
10.3
146
794
M79.1
ICD-10 Finland
Myalgia
1.8
10.3
171
983
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
2.6
10.3
76
307
SPAT1256
SPAT
Intramuscular and subcutaneous injection
0.6
10.3
267
3763
S01AD03
ATC
aciclovir; ophthalmic
2.9
10.2
60
211
L28
ICPC
Limited function/disability (L)
1.8
10.2
199
1208
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.8
10.2
202
1231
D06
ICPC
Abdominal pain localized other
2.2
10.2
107
513
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
10.1
271
1800
L82
ICD-10 Finland
Seborrhoeic keratosis
1.8
10.1
192
1155
N06AX11
ATC
mirtazapine; oral
1.5
10.1
386
2799
R05
ICPC
Cough
1.6
10.1
265
1749
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.3
10.1
93
422
N05CF02
ATC
zolpidem; oral
1.7
10.1
212
1314
Z50.1
ICD-10 Finland
Other physical therapy
2.5
10.0
80
336
J01MA06
ATC
norfloxacin; oral
1.8
10.0
187
1120
N03AX09
ATC
lamotrigine; oral
2.7
9.9
66
250
R52.9
ICD-10 Finland
Pain, unspecified
2.1
9.9
112
557
RS220
NOMESCO Finland
NA
5.3
9.9
29
56
R4130
NOMESCO Finland
Speech therapy
4.0
9.9
38
97
J05AB01
ATC
aciclovir; systemic
1.6
9.9
257
1696
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.2
9.8
103
496
G44.2
ICD-10 Finland
Tension-type headache
1.8
9.8
172
1006
R03AK07
ATC
formoterol and budesonide; inhalant
1.7
9.8
234
1506
R06AX22
ATC
ebastine; oral
1.7
9.7
214
1347
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
5.2
9.7
29
57
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
3.0
9.7
56
195
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.1
9.7
115
583
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
5.9
9.7
26
45
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
5.9
9.7
26
45
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
3.2
9.6
49
157
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
3.0
9.6
55
190
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.2
9.6
92
426
A28
ICPC
Limited function/disability NOS
1.8
9.6
177
1055
H20.1
ICD-10 Finland
Chronic iridocyclitis
7.2
9.5
22
31
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
2.6
9.5
68
271
A07DA03
ATC
loperamide; oral
2.9
9.5
56
199
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.9
9.5
141
781
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.6
9.3
67
267
UJD02
NOMESCO Finland
Gastroscopy
2.5
9.3
70
287
L03AB07
ATC
interferon beta-1a; parenteral
9.6
9.3
18
19
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.9
9.3
143
801
R51
ICD-10 Finland
Headache
2.5
9.2
72
298
Z53.2
ICD-10 Finland
Procedure not carried out because of patient's decision for other and unspecified reasons
6.1
9.2
24
40
H16.0
ICD-10 Finland
Corneal ulcer
2.6
9.2
66
263
RS221
NOMESCO Finland
NA
4.8
9.2
29
61
S01EE04
ATC
travoprost; ophthalmic
3.7
9.2
39
109
H43.1
ICD-10 Finland
Vitreous haemorrhage
3.7
9.2
38
104
R03AC03
ATC
terbutaline; inhalant
1.7
9.1
180
1093
WW200
NOMESCO Finland
Immunization
3.3
9.1
44
136
CJ2M4
NOMESCO Finland
Scans and measurement printouts for intraocular lens power calculation
5.9
9.1
24
41
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
9.1
534
4223
S01BC03
ATC
diclofenac; ophthalmic
3.3
9.0
44
137
H57.0
ICD-10 Finland
Anomalies of pupillary function
36.9
9.0
11
*
N06AX21
ATC
duloxetine; oral
1.9
9.0
138
773
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
2.9
9.0
53
188
303
Kela drug reimbursment
Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)
6.6
9.0
22
34
H54.7
ICD-10 Finland
Unspecified visual loss
7.5
8.9
20
27
3AC01
NOMESCO Finland
NA
6.1
8.9
23
38
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.7
8.9
178
1086
R06AE07
ATC
cetirizine; oral
1.4
8.8
531
4211
R35
ICD-10 Finland
Polyuria
2.3
8.8
82
375
R01AD08
ATC
fluticasone; nasal
1.5
8.8
329
2366
109
Kela drug reimbursment
Multiple sclerosis
6.0
8.8
23
39
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.5
8.7
311
2211
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.5
8.7
346
2520
N05CD07
ATC
temazepam; oral
1.8
8.6
164
986
R2110
NOMESCO Finland
Giving the first information
2.1
8.6
94
460
S01AX11
ATC
[U] ofloxacin; ophthalmic
2.7
8.6
58
222
R07.3
ICD-10 Finland
Other chest pain
1.9
8.6
119
641
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.0
8.5
105
543
R06.0
ICD-10 Finland
Dyspnoea
1.5
8.5
297
2099
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
27.7
8.5
11
*
J01FA01
ATC
erythromycin; systemic
1.7
8.5
169
1031
M03BX02
ATC
tizanidine; oral
1.4
8.5
729
6164
E66.8
ICD-10 Finland
Other obesity
2.4
8.5
73
320
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.1
8.4
99
500
TND32
NOMESCO Finland
Custom moulded splint, wrist or hand
4.5
8.4
28
63
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
8.4
598
4883
N02AJ06
ATC
codeine and paracetamol; systemic
1.5
8.4
421
3217
J01CA04
ATC
amoxicillin; systemic
1.5
8.4
985
8819
M25.5
ICD-10 Finland
Pain in joint
1.5
8.3
330
2401
J45.1
ICD-10 Finland
Nonallergic asthma
2.1
8.3
90
441
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
10.8
8.3
15
14
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.0
8.3
105
548
S01ED51
ATC
timolol, combinations; ophthalmic
2.1
8.3
96
482
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
2.3
8.2
72
320
R03AC13
ATC
formoterol; inhalant
2.3
8.2
74
332
J01FF01
ATC
clindamycin; systemic
1.5
8.1
310
2233
F45.8
ICD-10 Finland
Other somatoform disorders
2.1
8.1
89
438
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.5
8.1
389
2938
R83
ICPC
Respiratory infection other
1.5
8.1
267
1860
TCC40
NOMESCO Finland
Closure of lacrimal canaliculus with plug
11.8
8.1
14
12
H52.2
ICD-10 Finland
Astigmatism
4.5
8.1
27
61
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.0
8.1
101
524
N05BA04
ATC
oxazepam; oral
1.5
8.1
296
2115
M54.5
ICD-10 Finland
Low back pain
1.5
8.1
382
2880
K80
ICPC
Cardiac arrhythmia NOS
2.1
8.0
90
449
J45
ICD-10 Finland
Asthma
1.8
8.0
127
720
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
4.8
8.0
25
53
M03BC51
ATC
orphenadrine, combinations; systemic
1.5
7.9
334
2455
B01AB05
ATC
enoxaparin; parenteral
1.5
7.9
345
2554
J45.9
ICD-10 Finland
Asthma, unspecified
1.6
7.9
215
1428
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
1.8
7.9
142
840
H53.8
ICD-10 Finland
Other visual disturbances
5.4
7.8
22
41
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
4.4
7.8
27
63
KMAK
NOMESCO Finland
NA
1.4
7.8
597
4911
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.0
7.8
103
544
K03.64
ICD-10 Finland
Dental calculus supragingival
1.5
7.8
320
2337
XKD06
NOMESCO Finland
Physiologic investigation of micturition
2.9
7.8
45
158
IGY99
NOMESCO Finland
Other psychiatric treatment contact
4.5
7.8
26
59
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.9
7.8
118
657
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.0
7.8
91
462
114
Kela drug reimbursment
Glaucoma
1.9
7.8
111
608
N02BE01
ATC
paracetamol; systemic, rectal
1.5
7.8
1054
9608
K29.3
ICD-10 Finland
Chronic superficial gastritis
2.9
7.7
45
159
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.4
7.7
64
278
SPAT1342
SPAT
Referral to specialised care
4.6
7.7
25
55
S06.0
ICD-10 Finland
Concussion
1.8
7.7
125
714
R11
ICD-10 Finland
Nausea and vomiting
1.9
7.7
106
572
TQW99
NOMESCO Finland
Other minor procedure on skin
2.3
7.7
66
292
H40.12
ICD-10 Finland
Pigmentary glaucoma
25.2
7.6
10
*
CKC10
NOMESCO Finland
Local photocoagulation of retina
3.8
7.6
30
80
SPAT1249
SPAT
Treatment-related counselling outside office
0.7
7.6
268
3595
H53.4
ICD-10 Finland
Visual field defects
3.4
7.6
35
106
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
3.4
7.6
35
106
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
4.3
7.5
26
61
L01
ICPC
Neck symptom/complaint
1.7
7.5
167
1051
H02AB04
ATC
methylprednisolone; systemic
1.7
7.5
173
1098
R21
ICPC
Throat symptom/complaint
1.6
7.5
226
1539
N30.0
ICD-10 Finland
Acute cystitis
1.7
7.5
171
1082
R74
ICPC
Upper respiratory infection acute
1.5
7.4
317
2333
A91
ICPC
Abnormal result investigation NOS
2.5
7.4
56
232
R01BA52
ATC
pseudoephedrine, combinations; oral
1.4
7.4
358
2700
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.7
7.4
167
1053
H10.4
ICD-10 Finland
Chronic conjunctivitis
5.6
7.4
20
36
UJF92
NOMESCO Finland
Capsular endoscopy
3.7
7.4
30
82
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
2.2
7.4
76
363
Z96.1
ICD-10 Finland
Presence of intraocular lens
1.7
7.4
151
928
M01AB05
ATC
diclofenac; systemic, rectal
1.4
7.3
786
6816
M53.0
ICD-10 Finland
Cervicocranial syndrome
1.9
7.3
109
603
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.1
7.3
76
366
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
1.7
7.3
152
940
K07.63
ICD-10 Finland
Pain in the jaw joint UNS
3.7
7.3
30
83
M01AH02
ATC
rofecoxib; oral
1.7
7.3
158
986
H01.0
ICD-10 Finland
Blepharitis
2.2
7.3
71
333
WYA10
NOMESCO Finland
First aid or other corresponding healthcare contact
1.9
7.2
97
518
M02AA07
ATC
piroxicam; topical
1.4
7.2
431
3380
H66
ICD-10 Finland
Suppurative and unspecified otitis media
3.3
7.2
34
105
XJC02
NOMESCO Finland
Mesurement of oesophageal pressure and pressure profile of lower oesophageal sphincter
7.3
7.2
16
22
XCH00
NOMESCO Finland
Eye pressure measurement
2.6
7.2
50
197
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
1.9
7.2
96
512
H26.02
ICD-10 Finland
Presenil cataract
3.0
7.1
38
128
X57
ICD-10 Finland
Unspecified privation
3.1
7.1
36
117
C10AA07
ATC
rosuvastatin; oral
1.5
7.1
253
1790
M03BX01
ATC
baclofen; systemic
3.7
7.1
29
80
157
Kela drug reimbursment
Dimethyl fumarate, glatiramer acetate, interferon beta and teriflunomid (Multiple sclerosis)
5.7
7.1
19
34
TDM10
NOMESCO Finland
Puncture of maxillary antrum
2.5
7.0
53
219
SPAT1312
SPAT
General health counselling
0.7
7.0
202
2823
H33.0
ICD-10 Finland
Retinal detachment with retinal break
3.0
7.0
37
124
F01
ICPC
Eye pain
2.9
7.0
41
146
H60
ICD-10 Finland
Otitis externa
2.5
7.0
52
213
ZXY51
NOMESCO Finland
2-person team, doctor-nurse
4.5
7.0
23
52
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
2.1
6.9
71
340
EB1WA
NOMESCO Finland
NA
6.4
6.9
17
27
S01FA02
ATC
scopolamine; ophthalmic
5.5
6.9
19
35
U01
ICPC
Dysuria/painful urination
2.0
6.9
88
459
M54.2
ICD-10 Finland
Cervicalgia
2.0
6.9
82
419
K59.1
ICD-10 Finland
Functional diarrhoea
2.2
6.9
68
320
K02.9
ICD-10 Finland
Dental caries, unspecified
3.8
6.9
27
72
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.6
6.9
205
1393
SPAT1310
SPAT
Counselling related to known health issue
0.7
6.9
198
2768
K03.65
ICD-10 Finland
Deposits [accretions] on teeth betel
1.5
6.9
219
1512
T78.4
ICD-10 Finland
Allergy, unspecified
2.3
6.8
60
267
D07AA02
ATC
hydrocortisone; topical
1.7
6.8
157
997
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.8
6.8
121
711
R1250
NOMESCO Finland
Evaluation of functional capability
3.5
6.8
30
88
N03AF01
ATC
carbamazepine; oral, rectal
2.1
6.8
72
349
XX9AW
NOMESCO Finland
Production of copy from X-ray picture
2.6
6.8
45
174
ICC04
NOMESCO Finland
Psychiatric treatment plan, permanent discontinuation
4.0
6.8
25
63
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
2.6
6.8
47
184
SHA04
NOMESCO Finland
Correction of physiology of bite - very demanding therapy visit
4.7
6.7
21
45
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
2.8
6.7
40
145
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
2.5
6.7
48
194
WX320
NOMESCO Finland
Spinalanesthesy
1.5
6.7
252
1801
CG2Z4
NOMESCO Finland
Specialised imaging of cornea
22.6
6.7
9
*
D06BB03
ATC
aciclovir; topical
2.2
6.7
65
307
W22
ICD-10 Finland
Striking against or struck by other object(s)
2.1
6.6
71
347
A02BC03
ATC
lansoprazole; oral
1.4
6.6
334
2532
EAV
NOMESCO Finland
NA
3.8
6.6
26
70
IAB11
NOMESCO Finland
Psychiatric mood consultation
12.3
6.6
11
9
A06AD11
ATC
lactulose; oral
1.6
6.6
168
1097
D22
ICD-10 Finland
Melanocytic naevi
2.4
6.6
53
228
H26.4
ICD-10 Finland
After-cataract
1.8
6.6
115
673
M01AG02
ATC
tolfenamic acid; oral, rectal
1.6
6.6
184
1229
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.4
6.5
491
3989
R13
ICD-10 Finland
Dysphagia
2.0
6.5
79
405
H19.3*M35.0
ICD-10 Finland
Keratoconjunctivitis sicca
10.1
6.5
12
12
A01
ICPC
Pain general/multiple sites
1.9
6.5
91
493
XKD00
NOMESCO Finland
Uroflowmetry
1.6
6.5
160
1035
4730A
ICD-9 Finland
Chronic sinusitis, Maxillary
3.6
6.5
27
76
PA6AE
NOMESCO Finland
Ulrasound examination of neck vasculature
5.1
6.5
19
38
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
2.4
6.5
52
222
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
4.5
6.5
21
47
H01
ICPC
Ear pain/earache
1.8
6.5
118
701
WX890
NOMESCO Finland
Intesive care monitoring
6.2
6.5
16
26
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.0
6.5
77
395
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.4
6.5
326
2473
N06AB10
ATC
escitalopram; oral
1.5
6.5
221
1547
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
1.8
6.5
111
648
ZX120
NOMESCO Finland
Intravenous
1.8
6.4
109
634
R03BA01
ATC
beclometasone; inhalant
1.6
6.4
168
1105
H15.0
ICD-10 Finland
Scleritis
14.4
6.4
10
7
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
3.3
6.4
29
88
K29.5
ICD-10 Finland
Chronic gastritis, unspecified
2.7
6.4
39
145
N89
ICPC
Migraine
2.7
6.4
39
145
M01AB55
ATC
diclofenac, combinations; oral
1.9
6.4
88
477
H10
ICD-10 Finland
Conjunctivitis
2.0
6.3
78
405
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
2.8
6.3
38
139
R06AX13
ATC
loratadine; oral
1.6
6.3
179
1199
U02
ICPC
Urinary frequency/urgency
1.6
6.3
158
1025
M01AE02
ATC
naproxen; oral, rectal
1.3
6.3
669
5733
K07.60
ICD-10 Finland
Snapping jaw
2.2
6.3
62
293
S93.4
ICD-10 Finland
Sprain and strain of ankle
1.8
6.3
108
630
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
4.0
6.3
23
58
SPAT1153
SPAT
Removal of sutures
0.7
6.3
192
2663
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.4
6.3
371
2893
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
3.1
6.3
31
100
N06AA09
ATC
amitriptyline; systemic
1.7
6.3
123
748
37700
ICD-8 Finland
Other diseases of retina and optic nerve, Haemorrhagia corporis vitrei
+∞
6.3
6
*
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.8
6.2
111
655
D01AE16
ATC
amorolfine; topical
1.7
6.2
131
813
A29
ICPC
General symptom/complaint other
1.7
6.2
129
795
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.1
6.2
62
296
TUPEI
NOMESCO Finland
NA
2.5
6.2
47
194
S13.4
ICD-10 Finland
Sprain and strain of cervical spine
2.5
6.2
44
177
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
2.6
6.1
41
160
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
3.4
6.1
27
80
G40.9
ICD-10 Finland
Epilepsy, unspecified
2.4
6.1
47
197
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
4.3
6.1
21
50
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.5
6.1
228
1624
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
1.7
6.1
110
652
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
4.7
6.1
19
41
R5140
NOMESCO Finland
Monitoring the use of the aid
1.7
6.1
111
661
92100
ICD-8 Finland
Contusion of eye and orbit, Current injury
8.6
6.1
12
14
WVA20
NOMESCO Finland
Medicine administration
3.2
6.0
29
92
CKC15
NOMESCO Finland
Panretinal photocoagulation
6.7
6.0
14
21
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
6.7
6.0
14
21
W19
ICD-10 Finland
Unspecified fall
1.8
6.0
100
576
R01AD05
ATC
budesonide; nasal
1.8
6.0
95
541

Mortality – FinRegistry

Association

Association between endpoint H7_EYEADNEXOTH and mortality.

Females

Parameter HR [95% CI] p-value
H7_EYEADNEXOTH 1.196 [1.08, 1.33] < 0.001
Birth year 0.993 [0.98, 1.0] 0.114

During the follow-up period (1.1.1998 — 31.12.2019), 690 out of 4383 females with H7_EYEADNEXOTH died.

Males

Parameter HR [95% CI] p-value
H7_EYEADNEXOTH 1.306 [1.15, 1.49] < 0.001
Birth year 0.989 [0.98, 1.0] 0.022

During the follow-up period (1.1.1998 — 31.12.2019), 533 out of 3224 males with H7_EYEADNEXOTH died.

Mortality risk

Mortality risk for people of age

years, who have H7_EYEADNEXOTH.

N-year risk Females Males
1 0.113% 0.234%
5 0.623% 1.597%
10 1.492% 3.945%
15 2.92% 7.62%
20 5.275% 13.355%

Relationships between endpoints

Index endpoint: H7_EYEADNEXOTH – Other specified and unspecified disorders of eye and adnexa

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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