Risteys · I9

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — I45.0, I45.1 Hospital discharge: ICD-9 — 4264 Cause of death: ICD-10 — I45.0, I45.1 Cause of death: ICD-9 — 4264 2 out of 7 registries used, show all original rules.	1380
4. Check minimum number of events None	1380
5. Include endpoints None	1380
6. Filter based on genotype QC (FinnGen only)	1380

	All	Female	Male
Number of individuals
Whole population	9484	3939	5460
Only index persons	7783	3301	4482
Unadjusted period prevalence (%)
Whole population	0.14	0.11	0.15
Only index persons	0.15	0.12	0.17
Median age at first event (years)
Whole population	68.95	70.74	67.60
Only index persons	67.26	68.85	66.09

	All	Female	Male
Number of individuals	1380	534	846
Unadjusted period prevalence (%)	0.30	0.18	0.37
Median age at first event (years)	66.67	63.86	68.44

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
1222: Matched controls
12218

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

I48

ICD-10 Finland

Atrial fibrillation and flutter

97.0

323.0

368

I45.1

ICD-10 Finland

Other and unspecified right bundle-branch block

1662.7

323.0

552

I45.0

ICD-10 Finland

Right fascicular block

1436.2

323.0

667

I50.9

ICD-10 Finland

Heart failure, unspecified

89.2

216.3

238

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

10.2

213.9

487

747

290

Kela drug reimbursment

Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation

244.3

203.2

204

XFP20

NOMESCO Finland

Check up of cardiac pacemaker

444.4

194.8

190

207

Kela drug reimbursment

Chronic arrhythmias

142.0

192.9

202

351

Kela drug reimbursment

Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation

+∞

180.8

169

Z95.0

ICD-10 Finland

Presence of electronic cardiac devices

249.3

151.8

153

FPE20

NOMESCO Finland

Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes

443.4

123.0

121

I50.0

ICD-10 Finland

Congestive heart failure

142.7

121.7

128

B01AA03

ATC

warfarin; systemic

7.0

112.9

310

562

XF404

NOMESCO Finland

Ambulatory ECG

12.2

107.1

204

197

FM1AE

NOMESCO Finland

Standard cardiac ultrasound examination

6.3

104.2

312

629

C07AB07

ATC

bisoprolol; oral

3.7

100.8

666

2960

Z45.0

ICD-10 Finland

Adjustment and management of cardiac devices

523.3

98.9

TFP20

NOMESCO Finland

Cardiodefibrillation

111.1

94.5

102

I49.3

ICD-10 Finland

Ventricular premature depolarization

26.1

91.6

129

I44.2

ICD-10 Finland

Atrioventricular block, complete

+∞

89.7

I50.1

ICD-10 Finland

Left ventricular failure

430.1

81.9

I49.5

ICD-10 Finland

Sick sinus syndrome

401.4

76.7

C03CA01

ATC

furosemide; systemic

3.6

73.9

430

1617

R06.0

ICD-10 Finland

Dyspnoea

3.6

72.2

401

1447

C01AA05

ATC

digoxin; systemic

13.5

71.5

128

105

I44.0

ICD-10 Finland

Atrioventricular block, first degree

84.4

70.9

I44.1

ICD-10 Finland

Atrioventricular block, second degree

717.2

69.7

FN1AC

NOMESCO Finland

Angiography of heart and/or coronary arteries

3.9

69.1

338

1091

GD1AA

NOMESCO Finland

Thorax X-ray examination

3.0

68.8

625

3189

I47.1

ICD-10 Finland

Supraventricular tachycardia

123.6

65.6

B01AF02

ATC

apixaban; oral

13.7

64.4

114

I35.0

ICD-10 Finland

Aortic (valve) stenosis

40.6

63.7

I48.0

ICD-10 Finland

Paroxysmal atrial fibrillation

92.7

63.6

I35.1

ICD-10 Finland

Aortic (valve) insufficiency

60.4

63.4

I48.9

ICD-10 Finland

Atrial fibrillation and atrial flutter, unspecified

224.7

62.7

XF402

NOMESCO Finland

ECG with work load test

4.8

55.5

204

492

K78

ICPC

Atrial fibrillation/flutter

14.9

55.2

J45.9

ICD-10 Finland

Asthma, unspecified

3.5

54.5

299

1035

I49.9

ICD-10 Finland

Cardiac arrhythmia, unspecified

7.1

54.1

139

216

I34.09

ICD-10 Finland

Mitral (valve) insufficiency

191.7

53.4

J45.1

ICD-10 Finland

Nonallergic asthma

5.7

51.7

160

317

203

Kela drug reimbursment

Chronic asthma and similar chronic obstructive pulmonary diseases

3.1

50.4

334

1318

R07.4

ICD-10 Finland

Chest pain, unspecified

2.9

49.8

387

1696

4264A

ICD-9 Finland

Conduction disorders, Right bundle branch block

+∞

48.2

I42.0

ICD-10 Finland

Dilated cardiomyopathy

+∞

48.2

C03DA01

ATC

spironolactone; oral

5.1

47.7

163

361

201

Kela drug reimbursment

Chronic cardiac insufficiency

12.2

47.5

J45.0

ICD-10 Finland

Predominantly allergic asthma

4.8

46.2

166

387

XF400

NOMESCO Finland

ECG with 12 standard connections

3.3

46.0

271

976

I45.9

ICD-10 Finland

Conduction disorder, unspecified

442.5

43.5

C01DA08

ATC

isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal

2.7

42.1

353

1590

FM1DE

NOMESCO Finland

Doppler ultrasound examination of heart

5.7

42.0

127

243

TFP34

NOMESCO Finland

Electrophysiological investigation

217.1

41.1

I44.4

ICD-10 Finland

Left anterior fascicular block

+∞

40.8

C01BD01

ATC

amiodarone; systemic

111.3

40.0

I10

ICD-10 Finland

Essential (primary) hypertension

2.2

37.3

769

5330

I25.1

ICD-10 Finland

Atherosclerotic heart disease

2.6

37.2

317

1427

FPE00

NOMESCO Finland

Implantation of transvenous cardiac pacemaker with ventricular electrode

195.8

37.0

H02AB06

ATC

prednisolone; systemic

2.2

36.0

593

3696

I45.2

ICD-10 Finland

Bifascicular block

190.5

35.9

I49.1

ICD-10 Finland

Atrial premature depolarization

19.4

35.5

I48.2

ICD-10 Finland

Chronic atrial fibrillation

+∞

33.5

I47.2

ICD-10 Finland

Ventricular tachycardia

119.9

32.8

FPE30

NOMESCO Finland

Replacement of transvenous cardiac pacemaker pulse generator

+∞

32.4

R03AC02

ATC

salbutamol; inhalant

2.1

32.4

600

3870

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

3.1

32.1

200

734

AS4

Physiological pacemaker insertion DDD (R)

325.0

32.0

R03DC03

ATC

montelukast; oral

2.9

31.8

213

819

I50

ICD-10 Finland

Heart failure

16.6

31.8

SPAT1263

SPAT

Sampling

2.1

31.7

522

3195

I35.2

ICD-10 Finland

Aortic (valve) stenosis with insufficiency

48.9

31.7

J46

ICD-10 Finland

Status asthmaticus

9.3

31.7

N02BE01

ATC

paracetamol; systemic, rectal

2.4

31.4

1018

8272

XF640

NOMESCO Finland

12.7

30.7

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

2.7

30.7

235

981

R03AK06

ATC

salmeterol and fluticasone; inhalant

2.8

30.3

215

857

R03AC12

ATC

salmeterol; inhalant

4.7

29.9

105

237

E11.9

ICD-10 Finland

Type 2 diabetes mellitus, without complications

2.3

29.7

339

1750

R03BA05

ATC

fluticasone; inhalant

2.6

29.3

242

1055

R00.1

ICD-10 Finland

Bradycardia, unspecified

9.9

29.1

AA1AD

NOMESCO Finland

CT of head and brain

2.3

28.2

325

1677

C07AA07

ATC

sotalol; systemic

8.2

27.9

C01BC04

ATC

flecainide; systemic

48.3

27.5

C01DA14

ATC

isosorbide mononitrate; oral

2.6

26.9

225

983

R03BA02

ATC

budesonide; inhalant

2.6

26.8

227

997

R55

ICD-10 Finland

Syncope and collapse

3.0

26.7

167

610

I45.3

ICD-10 Finland

Trifascicular block

143.1

26.7

J18.9

ICD-10 Finland

Pneumonia, unspecified

2.2

26.7

332

1768

C08DA01

ATC

verapamil; systemic

6.9

26.7

104

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

2.1

26.4

369

2067

I11.0

ICD-10 Finland

Hypertensive heart disease with (congestive) heart failure

61.4

26.1

G47.3

ICD-10 Finland

Sleep apnoea

2.4

25.9

266

1290

I48.1

ICD-10 Finland

Persistent atrial fibrillation

74.3

25.9

AQ1

Conventional electrophysiological examination

255.0

24.7

I42.9

ICD-10 Finland

Cardiomyopathy, unspecified

132.6

24.7

K80

ICPC

Cardiac arrhythmia NOS

4.7

24.0

193

A02BC02

ATC

pantoprazole; systemic

1.9

24.0

747

5586

I49.4

ICD-10 Finland

Other and unspecified premature depolarization

10.3

23.9

J45

ICD-10 Finland

Asthma

3.2

23.2

132

451

AN1

Coronary angiography

2.9

23.1

151

566

C01DA02

ATC

glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal

2.1

23.1

296

1585

SPAT1253

SPAT

Initiation, adjustment, discontinuation or repetition of medication

2.0

23.1

354

2041

PH1AC

NOMESCO Finland

Flebography of over extremity with X-ray

85.0

22.7

Z95.2

ICD-10 Finland

Presence of prosthetic heart valve

40.9

22.7

R03DA04

ATC

theophylline; systemic, rectal

3.4

22.3

112

348

J45.8

ICD-10 Finland

Mixed asthma

5.5

22.3

127

H02AB07

ATC

prednisone; oral

2.5

22.2

199

894

J20.9

ICD-10 Finland

Acute bronchitis, unspecified

2.4

22.1

216

1018

4273A

ICD-9 Finland

Cardiac dysrhythmias, Atrial fibrillation and flutter

+∞

21.9

I44.7

ICD-10 Finland

Left bundle-branch block, unspecified

29.6

21.9

R02

ICPC

Shortness of breath/dyspnoea

2.8

21.9

150

578

TPH04

NOMESCO Finland

Cathetrisation of vein

2.2

21.6

251

1282

Z03.5

ICD-10 Finland

Observation for other suspected cardiovascular diseases

3.6

21.5

101

298

C09AA05

ATC

ramipril; oral

2.0

21.4

314

1768

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

2.6

21.0

173

741

FM1BE

NOMESCO Finland

Cardiac ultrasound examination through oesophagus

4.9

21.0

150

N02AX02

ATC

tramadol; systemic, rectal

1.8

20.9

517

3516

I34.00

ICD-10 Finland

Mitral (valve) incompetence NOS or of specified cause, except rheumatic

+∞

20.9

R53

ICD-10 Finland

Malaise and fatigue

2.2

20.5

246

1272

Z01.8

ICD-10 Finland

Other specified special examinations

2.1

20.5

255

1336

ZXD05

NOMESCO Finland

Urgent procedure

1.9

20.1

342

2035

I20.09

ICD-10 Finland

Unstable angina

3.7

19.8

248

R00.2

ICD-10 Finland

Palpitations

4.2

19.7

194

B01AF01

ATC

rivaroxaban; oral

2.8

19.6

133

507

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

2.3

19.6

195

922

I25.9

ICD-10 Finland

Chronic ischaemic heart disease, unspecified

2.8

19.5

134

518

R03BB04

ATC

tiotropium bromide; inhalant

2.6

19.1

153

644

Angiography of the heart and coronary arteries

3.3

18.9

318

I20.99

ICD-10 Finland

Angina pectoris, unspecified

3.3

18.9

313

TFP46

NOMESCO Finland

Ablation treatment of atrial fibrillation

+∞

18.8

H02AB04

ATC

methylprednisolone; systemic

2.3

18.6

186

877

J01DB01

ATC

cefalexin; oral

1.8

18.6

904

7470

GD1PA

NOMESCO Finland

X-ray examination of the lungs in one projection

3.0

18.6

115

414

WX892

NOMESCO Finland

Monitored bed care

3.4

18.4

291

I20.89

ICD-10 Finland

Other angina pectoris unspecified coronary artery status

4.1

18.3

187

J01MA12

ATC

levofloxacin; systemic

2.1

18.3

251

1364

SPAT1148

SPAT

Treatment of chronic ulcer or burn

2.3

18.3

178

832

GD1LA

NOMESCO Finland

44.7

18.3

R03AK07

ATC

formoterol and budesonide; inhalant

2.2

18.1

217

1113

E11.8

ICD-10 Finland

Type 2 diabetes mellitus, with unspecified complications

2.7

17.8

131

527

I34.1

ICD-10 Finland

Mitral (valve) prolapse

67.6

17.8

I46.0

ICD-10 Finland

Cardiac arrest with successful resuscitation

+∞

17.7

TFP35

NOMESCO Finland

Electroanatomical mapping

+∞

17.7

R03AC13

ATC

formoterol; inhalant

3.6

17.6

236

SPAT1254

SPAT

Administration of medicine

2.3

17.3

182

880

C08CA01

ATC

amlodipine; oral

1.7

17.2

439

2964

I11.9

ICD-10 Finland

Hypertensive heart disease without (congestive) heart failure

4.9

17.0

119

R03AC03

ATC

terbutaline; inhalant

2.3

16.9

169

798

I36.1

ICD-10 Finland

Nonrheumatic tricuspid (valve) insufficiency

64.2

16.8

FME20

NOMESCO Finland

Transvenous aortic valve replacement via femoral artery

+∞

16.7

XF409

NOMESCO Finland

Other special ECG

+∞

16.7

FMD10

NOMESCO Finland

Replacement of aortic valve using biological prosthesis

+∞

16.7

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

1.7

16.7

425

2861

J44.8

ICD-10 Finland

Other specified chronic obstructive pulmonary disease

2.3

16.4

156

719

GD1DD

NOMESCO Finland

High resolution CT examination of lungs

3.6

16.2

219

I49.8

ICD-10 Finland

Other specified cardiac arrhythmias

8.0

16.1

XF600

NOMESCO Finland

Bloodpressure measurement

3.2

16.0

282

FN1BC

NOMESCO Finland

Extensive angiography of hear and/or coronary arteries

3.7

15.9

202

SPAT1262

SPAT

Handing over of treatment supplies

2.0

15.9

239

1343

C07AB02

ATC

metoprolol; systemic

2.0

15.8

235

1314

I47.9

ICD-10 Finland

Paroxysmal tachycardia, unspecified

33.8

15.8

A46

ICD-10 Finland

Erysipelas

2.2

15.7

165

794

I42.2

ICD-10 Finland

Other hypertrophic cardiomyopathy

+∞

15.7

TFP30

NOMESCO Finland

Cathetric examination for cardiac arrythmia

86.2

15.6

K99

ICPC

Cardiovascular disease other

7.0

15.5

XFE00

NOMESCO Finland

Epicardial ultrasonography

7.5

15.5

J01CA04

ATC

amoxicillin; systemic

1.7

15.4

853

7079

E11.7

ICD-10 Finland

Type 2 diabetes mellitus, with multiple complications

3.5

15.3

219

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

1.7

15.2

360

2355

Z95.5

ICD-10 Finland

Presence of coronary angioplasty implant and graft

4.2

15.1

144

S18

ICPC

Laceration/cut

1.7

15.1

472

3348

B01AC04

ATC

clopidogrel; oral

2.0

14.9

199

1064

FB1BD

NOMESCO Finland

Extensive CT examination of arteria pulmonalis

2.8

14.8

357

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

1.8

14.8

327

2088

R42

ICD-10 Finland

Dizziness and giddiness

1.9

14.7

255

1502

I25.2

ICD-10 Finland

Old myocardial infarction

2.9

14.7

330

K77

ICPC

Heart failure

12.0

14.6

206

Kela drug reimbursment

Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease

1.9

14.5

227

1290

SPAT1249

SPAT

Treatment-related counselling outside office

1.7

14.5

425

2953

FJA10

NOMESCO Finland

Transvenous biopsy of right ventricle

151.6

14.5

SPAT1097

SPAT

Recording of ECG

2.1

14.4

174

892

M79.6

ICD-10 Finland

Pain in limb

1.7

14.4

377

2534

TFC00

NOMESCO Finland

Catheterisation of right atrium or ventricle

27.5

14.3

A12BA01

ATC

potassium chloride; oral

3.5

14.2

205

SPAT1256

SPAT

Intramuscular and subcutaneous injection

1.6

14.0

486

3529

UJF32

NOMESCO Finland

Coloscopy

1.8

13.9

300

1898

R03AK03

ATC

[D] fenoterol & other drugs for obstructive airway dis; inhalant

2.7

13.9

385

I20.81

ICD-10 Finland

Other angina pectoris stenosed coronary artery

2.6

13.8

103

416

B01AB05

ATC

enoxaparin; parenteral

1.7

13.8

328

2141

J01AA02

ATC

doxycycline; systemic

1.6

13.7

866

7304

R03BA01

ATC

beclometasone; inhalant

2.1

13.7

170

879

SPAT1104

SPAT

Monitoring of emergency patient

2.8

13.7

333

B01AE07

ATC

dabigatran etexilate; oral

5.0

13.6

M54.5

ICD-10 Finland

Low back pain

1.7

13.6

332

2180

R96

ICPC

Asthma

2.5

13.6

111

471

TFC25

NOMESCO Finland

Transseptal catheterisation of left atrium or ventricle

+∞

13.6

FPG32

NOMESCO Finland

Implantation of cardioverter-defibrillator with atrial and ventricular electrodes

+∞

13.6

TFP44

NOMESCO Finland

Ablation treatment of typical atrial flutter

+∞

13.6

TFP32

NOMESCO Finland

Cathetric treatmen of cardiac arrythmia

+∞

13.6

SPAT1222

SPAT

Counselling/guidance promoting independent living

2.0

13.5

185

996

E66.01

ICD-10 Finland

Obesity due to excess calories

2.9

13.5

291

Z03.89

ICD-10 Finland

Observation for other suspected diseases and conditions

2.1

13.5

153

763

J06.9

ICD-10 Finland

Acute upper respiratory infection, unspecified

1.7

13.5

360

2427

103

Kela drug reimbursment

Diabetes, insulin-treated

1.7

13.4

329

2163

A49.9

ICD-10 Finland

Bacterial infection, unspecified

2.3

13.3

135

637

FXA00

NOMESCO Finland

Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure

4.8

13.3

J44.0

ICD-10 Finland

Chronic obstructive pulmonary disease with acute lower respiratory infection

3.1

13.3

239

I63.4

ICD-10 Finland

Cerebral infarction due to embolism of cerebral arteries

7.0

13.2

SPAT1312

SPAT

General health counselling

1.7

13.2

338

2249

M04AA01

ATC

allopurinol; systemic

2.1

13.2

161

830

R50.9

ICD-10 Finland

Fever, unspecified

2.1

13.1

158

808

R60.0

ICD-10 Finland

Localized oedema

2.3

13.1

129

603

A10AE04

ATC

insulin glargine; parenteral

2.4

13.0

113

496

E66.00

ICD-10 Finland

Metabolic syndrome

3.3

12.9

204

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

1.9

12.9

197

1105

C10AA01

ATC

simvastatin; oral

1.6

12.9

527

3960

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

1.7

12.8

335

2238

C08DB01

ATC

diltiazem; oral

2.9

12.8

292

Z95.1

ICD-10 Finland

Presence of aortocoronary bypass graft

3.7

12.7

153

J01FF01

ATC

clindamycin; systemic

1.7

12.7

294

1892

N05CF01

ATC

zopiclone; oral

1.6

12.7

373

2571

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

1.6

12.6

458

3337

I41.8*D86.8

ICD-10 Finland

Sarcoid myocarditis

+∞

12.5

I49.0

ICD-10 Finland

Ventricular fibrillation and flutter

+∞

12.5

I20.90

ICD-10 Finland

Angina pectoris, unspecified

3.7

12.4

152

J01FA06

ATC

roxithromycin; oral

1.6

12.3

422

3026

R03AK04

ATC

salbutamol and sodium cromoglicate; inhalant

7.5

12.2

N02AJ06

ATC

codeine and paracetamol; systemic

1.6

12.2

356

2447

R03BB01

ATC

ipratropium bromide; inhalant

2.9

12.2

254

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

1.6

12.2

357

2457

PA6DE

NOMESCO Finland

Neck artery ultrasound examination with Doppler method

3.0

12.2

235

R03AL02

ATC

salbutamol and ipratropium bromide; inhalant

7.9

12.1

J44.1

ICD-10 Finland

Chronic obstructive pulmonary disease with acute exacerbation, unspecified

3.9

12.1

129

I25.0

ICD-10 Finland

Atherosclerotic cardiovascular disease, so described

2.9

12.1

255

215

Kela drug reimbursment

Diabetes, non-insulin-treated

1.7

12.0

279

1794

PH2AE

NOMESCO Finland

Ultrasound examination of lower leg veins

2.2

12.0

126

606

TPH07

NOMESCO Finland

Cathetrisation of artery

2.3

11.9

117

547

I34.0

ICD-10 Finland

Mitral (valve) insufficiency

47.1

11.9

WX408

NOMESCO Finland

General anesthesy, balanced

1.7

11.9

299

1970

SPAT1260

SPAT

Consultation of another employee

1.9

11.8

202

1176

D64.9

ICD-10 Finland

Anaemia, unspecified

2.2

11.8

128

625

A02BC01

ATC

omeprazole; systemic

1.7

11.8

318

2138

N18.9

ICD-10 Finland

Chronic kidney disease, unspecified

3.0

11.6

232

R07.3

ICD-10 Finland

Other chest pain

2.3

11.6

105

472

R03AK08

ATC

formoterol and beclometasone; inhalant

3.7

11.6

140

I20.00

ICD-10 Finland

Unstable angina

3.9

11.5

120

SPAT1306

SPAT

Counselling and guidance related to nutrition and weight management

2.0

11.5

159

859

Initial pacemaker installation

+∞

11.5

289

Kela drug reimbursment

Combination product containing sacubitril and valsartan

+∞

11.5

AS2

Ventricular pacemaker insertion VVI (R)

+∞

11.5

I31.9

ICD-10 Finland

Disease of pericardium, unspecified

+∞

11.5

H25.8

ICD-10 Finland

Other senile cataract

2.0

11.4

154

824

R06AE07

ATC

cetirizine; oral

1.6

11.4

416

3017

SPAT1310

SPAT

Counselling related to known health issue

1.6

11.4

337

2315

A10AC01

ATC

insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)

2.4

11.4

410

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

1.9

11.4

165

908

R5140

NOMESCO Finland

Monitoring the use of the aid

2.2

11.3

117

560

XPX99

NOMESCO Finland

Other diagnostic examination of periferal vessel

2.6

11.3

320

A02BC05

ATC

esomeprazole; systemic

1.6

11.3

421

3070

R03DC01

ATC

zafirlukast; oral

5.4

11.2

N06AX11

ATC

mirtazapine; oral

1.6

11.2

322

2195

A06AC01

ATC

ispaghula (psylla seeds); oral

1.7

11.2

267

1730

E0000UV

ATC

1.6

11.0

403

2918

SPAT1153

SPAT

Removal of sutures

1.6

10.9

359

2533

N17.9

ICD-10 Finland

Acute renal failure, unspecified

3.5

10.8

143

K59.09

ICD-10 Finland

Constipation, unspecified

2.5

10.8

337

XG410

NOMESCO Finland

Flow-volume spirometry

3.2

10.7

182

A10BA02

ATC

metformin; oral

1.6

10.7

336

2338

FP4B5

NOMESCO Finland

ECG, prolonged recording (24 h)

21.7

10.7

E78.5

ICD-10 Finland

Hyperlipidaemia, unspecified

2.1

10.5

121

606

I71.2

ICD-10 Finland

Thoracic aortic aneurysm, without mention of rupture

5.1

10.5

N03AX16

ATC

pregabalin; oral

1.7

10.5

249

1607

EB1AA

NOMESCO Finland

Tooth X-ray examination

1.5

10.5

530

4122

G44.2

ICD-10 Finland

Tension-type headache

2.1

10.5

125

636

K44.9

ICD-10 Finland

Diaphragmatic hernia without obstruction or gangrene

2.4

10.5

418

C01BC03

ATC

propafenone; systemic

+∞

10.4

I51.4

ICD-10 Finland

Myocarditis, unspecified

+∞

10.4

AQ2

Electrophysiological electroanatomical examination

+∞

10.4

I30.9

ICD-10 Finland

Acute pericarditis, unspecified

+∞

10.4

I44.3

ICD-10 Finland

Other and unspecified atrioventricular block

+∞

10.4

Catheterization and pressure measurement of the left side of the heart

5.0

10.4

4130X

ICD-9 Finland

Angina pectoris, Angina decubitus[ANGINA PECTORIS (""""EFFORT ANGINA""""),MÄÄRITTELEMÄT]

4.7

10.3

4939X

ICD-9 Finland

Asthma, unspecified[ASTHMA BRONCHIALE NUD]

5.4

10.3

R03AL01

ATC

fenoterol and ipratropium bromide; inhalant

4.0

10.1

100

Z2446

NOMESCO Finland

Social worker

2.6

10.0

280

R03BA08

ATC

ciclesonide; inhalant

2.4

10.0

357

SPAT1216

SPAT

Assessment of functional ability

1.8

10.0

185

1106

FM1DG

NOMESCO Finland

Very extensive MRI examination of heart with high intesity magnet

40.4

10.0

CJE20

NOMESCO Finland

Phakoemulsification with implantation of artificial lens in posterior chamber

1.5

9.9

384

2806

A10AB05

ATC

insulin aspart; parenteral (insulins and analog. for injection, fast-acting)

2.4

9.8

366

K57.3

ICD-10 Finland

Diverticular disease of large intestine without perforation or abscess

1.7

9.7

202

1252

E78.9

ICD-10 Finland

Disorder of lipoprotein metabolism, unspecified

3.3

9.6

141

SPAT1250

SPAT

Comprehensive monitoring of chronic illness

1.6

9.6

324

2286

R01AD08

ATC

fluticasone; nasal

1.6

9.6

277

1883

205

Kela drug reimbursment

Chronic hypertension

1.6

9.6

333

2366

J15.9

ICD-10 Finland

Bacterial pneumonia, unspecified

2.1

9.5

105

517

J01FA09

ATC

clarithromycin; systemic

1.6

9.5

305

2126

K04

ICPC

Palpitations/awareness of heart

3.6

9.5

121

X59

ICD-10 Finland

Exposure to unspecified factor

1.8

9.5

184

1116

FN1BT

NOMESCO Finland

Extensive endovascular dilatation of coronary (PTCA) arteries

4.4

9.4

NH1AA

NOMESCO Finland

Ankle X-ray examination without contrast

2.6

9.4

265

K83

ICPC

Heart valve disease NOS

30.2

9.4

FPE40

NOMESCO Finland

Replacement of transvenous cardiac pacemaker electrode

+∞

9.4

TFJ02

NOMESCO Finland

Muscle biopsy of heart

+∞

9.4

4276B

ICD-9 Finland

Cardiac dysrhythmias, Premature beats[EXTRASYSTOLIA VENTRICULARIS]

+∞

9.4

42798

ICD-8 Finland

Symptomatic heart disease, Alia arrhytmia definita

+∞

9.4

TFP40

NOMESCO Finland

Ablation treatment for a-v node re-entry activation

+∞

9.4

C09DX04

ATC

valsartan and sacubitril; oral

+∞

9.4

AR6

Catheter ablation of arrhythmia, target: atrial fibrillation

+∞

9.4

FMD00

NOMESCO Finland

Replacement of aortic valve using mechanical prosthesis

+∞

9.4

381

Kela drug reimbursment

Combination product containing sacubitril and valsartan

+∞

9.4

M10.9

ICD-10 Finland

Gout, unspecified

2.5

9.3

313

SPAT1137

SPAT

Taking care of patient’s/customer’s hygiene

2.5

9.3

313

SPAT1301

SPAT

No procedures

1.5

9.3

333

2383

C10AA05

ATC

atorvastatin; oral

1.5

9.2

425

3214

T90

ICPC

Diabetes non-insulin dependent

1.6

9.2

261

1761

C03EA01

ATC

hydrochlorothiazide and potassium-sparing agents; oral

1.8

9.2

175

1056

SPAT1083

SPAT

Initiation and monitoring of IV fluid therapy

2.8

9.2

207

K02.1

ICD-10 Finland

Caries of dentine

1.5

9.2

522

4124

N06AB04

ATC

citalopram; systemic

1.7

9.1

218

1404

SPAT1211

SPAT

Application of soft bandage

2.1

9.1

102

505

P01AB01

ATC

metronidazole; oral, rectal

1.5

9.1

386

2868

C02DE01

ATC

8.4

9.1

XG412

NOMESCO Finland

Flow-volume spirometry with bronchospasmolysis

2.4

9.1

324

FM1CG

NOMESCO Finland

Extensive examination of hear with high intensity magnet

36.9

9.0

A04

ICPC

Weakness/tiredness general

1.9

9.0

128

699

Z2221

NOMESCO Finland

Medical doctor

1.6

8.9

272

1868

C09AA02

ATC

enalapril; systemic

1.6

8.9

228

1496

A10BH05

ATC

linagliptin; oral

2.6

8.9

244

I21.41

ICD-10 Finland

Acute subendocardial infarction stenosed coronary artery

2.7

8.9

214

Z48.0

ICD-10 Finland

Attention to surgical dressings and sutures

3.0

8.8

162

J01.0

ICD-10 Finland

Acute maxillary sinusitis

1.7

8.8

175

1067

S22.3

ICD-10 Finland

Fracture of rib

2.3

8.8

347

I21.49

ICD-10 Finland

Acute subendocardial infarction unspecified coronary artery status

2.5

8.8

268

ZXE10

NOMESCO Finland

More than one and less than three hours

1.5

8.8

375

2784

R00.0

ICD-10 Finland

Tachycardia, unspecified

3.7

8.8

103

WX722

NOMESCO Finland

PEEP

2.8

8.8

202

K05

ICPC

Irregular heartbeat other

4.4

8.8

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

1.7

8.7

187

1168

WZB00

NOMESCO Finland

Telephone receipt or other advice

1.6

8.7

250

1689

SPAT1156

SPAT

Guidance concerning treatment of rash and skin

1.8

8.7

154

907

WX110

NOMESCO Finland

Local anesthesy

1.4

8.6

679

5690

Z3231

NOMESCO Finland

Registered nurse

1.6

8.6

284

1988

SPAT1149

SPAT

Suture or treatment of traumatic wound

1.8

8.6

144

832

R5110

NOMESCO Finland

Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it

1.9

8.5

124

680

GD1AD

NOMESCO Finland

Thorax CT examination

2.9

8.5

178

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

2.0

8.5

110

579

B01AC07

ATC

dipyridamole; systemic

2.4

8.5

300

I42.8

ICD-10 Finland

Other cardiomyopathies

90.6

8.4

SPAT1325

SPAT

Vaccination

1.5

8.4

390

2940

M03BX02

ATC

tizanidine; oral

1.4

8.4

591

4838

SPAT1229

SPAT

Assessment of need for aid

2.1

8.4

452

F32.9

ICD-10 Finland

Depressive episode, unspecified

2.0

8.4

105

546

I42.1

ICD-10 Finland

Obstructive hypertrophic cardiomyopathy

+∞

8.3

4270A

ICD-9 Finland

Cardiac dysrhythmias, Paroxysmal supraventricular tachycardia

+∞

8.3

AR1

Catheter ablation of arrhythmia, target: AV node reentry activation (AVNRT)

+∞

8.3

FK1BT

NOMESCO Finland

Implantation of cardiac pacemaker with X-ray guidance

+∞

8.3

I41.8

ICD-10 Finland

Myocarditis in other diseases classified elsewhere

+∞

8.3

FPJ04

NOMESCO Finland

Revision of pacemaker generator with atrial and ventricular electrodes

+∞

8.3

FPE25

NOMESCO Finland

Implantation of biventricular cardiac pacemaker, atrial and ventricular electrodes, CRT-P (DDDR)

+∞

8.3

N03AX12

ATC

gabapentin; oral

1.8

8.3

156

936

J01CR02

ATC

amoxicillin and beta-lactamase inhibitor; systemic

1.4

8.3

479

3769

R51.80

ICD-10 Finland

Headache

1.9

8.3

122

672

J96.1

ICD-10 Finland

Chronic respiratory failure

3.8

8.3

SPAT1255

SPAT

Intravenous administration of medicine

2.3

8.2

342

J01MA14

ATC

moxifloxacin; systemic

2.1

8.2

478

A10AE05

ATC

insulin detemir; parenteral

2.5

8.1

264

J01MA02

ATC

ciprofloxacin; systemic

1.4

8.1

429

3321

B01AF03

ATC

edoxaban; oral

17.3

8.1

ZXE00

NOMESCO Finland

One hour or less

1.5

8.0

388

2942

W19

ICD-10 Finland

Unspecified fall

2.0

8.0

101

528

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

2.3

8.0

310

A10BB12

ATC

glimepiride; oral

2.0

8.0

491

M25.5

ICD-10 Finland

Pain in joint

1.6

7.9

256

1778

E11.2

ICD-10 Finland

Type 2 diabetes mellitus, with renal complications

3.1

7.9

140

R05

ICD-10 Finland

Cough

1.7

7.9

184

1173

K84

ICPC

Heart disease other

4.3

7.9

C01CA24

ATC

epinephrine; parenteral

2.6

7.9

210

E11.00

ICD-10 Finland

Non-insulin dependent diabetes diabetic hypoglycaemic coma

2.9

7.9

163

A06AD11

ATC

lactulose; oral

1.7

7.8

180

1146

I69.3

ICD-10 Finland

Sequelae of cerebral infarction

2.1

7.8

423

I70.2

ICD-10 Finland

Atherosclerosis of arteries of extremities

2.0

7.8

517

C09CA01

ATC

losartan; oral

1.6

7.8

249

1723

J01FA10

ATC

azithromycin; systemic

1.4

7.8

525

4239

ND2AA

NOMESCO Finland

Hand and fingers X-ray examination

2.1

7.8

411

D50.9

ICD-10 Finland

Iron deficiency anaemia, unspecified

2.2

7.8

363

EBA05

NOMESCO Finland

Complicated extraction of tooth

1.7

7.8

181

1154

M70.6

ICD-10 Finland

Trochanteric bursitis

1.9

7.8

118

659

49300

ICD-8 Finland

Asthma, bronchiale

3.2

7.7

126

K03.64

ICD-10 Finland

Dental calculus supragingival

1.6

7.7

237

1626

E000001

ATC

1.6

7.7

203

1341

FN2BA

NOMESCO Finland

Percutaneous transluminal coronary angioplasty with stent (includes balloon pre-dilation)

2.4

7.7

259

R05

ICPC

Cough

1.6

7.7

211

1405

I63.9

ICD-10 Finland

Cerebral infarction, unspecified

1.9

7.7

119

671

NH3BA

NOMESCO Finland

Foot and toes extensive X-ray examination

3.1

7.6

127

213

Kela drug reimbursment

Fat metabolism disorder associated with chronic coronary artery disease

2.0

7.6

465

X58

ICD-10 Finland

Exposure to other specified factors

1.8

7.5

123

704

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

2.0

7.5

459

SAA02

NOMESCO Finland

Basic examination of mouth

1.4

7.5

581

4808

A10BH01

ATC

sitagliptin; oral

1.9

7.5

110

609

R04.0

ICD-10 Finland

Epistaxis

2.2

7.5

336

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

2.1

7.4

371

DMB20

NOMESCO Finland

Functional endoscopic opening of maxillary antrum

2.5

7.4

232

NF1AA

NOMESCO Finland

Hip X-ray examination

1.9

7.4

102

550

AP4

Myocardial biopsy

80.5

7.4

I48.3

ICD-10 Finland

Typical atrial flutter

80.5

7.4

C09CA03

ATC

valsartan; oral

2.0

7.4

507

R31

ICD-10 Finland

Unspecified haematuria

1.8

7.4

117

664

C03EB01

ATC

furosemide and potassium-sparing agents; systemic

2.6

7.3

190

N19

ICD-10 Finland

Unspecified kidney failure

3.1

7.3

126

AB2

AVR bio, stent

+∞

7.3

AR5

Catheter ablation of arrhythmia, target: atrial flutter

+∞

7.3

FPE96

NOMESCO Finland

Other implantation or replacement of transvenous cardiac pacemaker

+∞

7.3

J09

ICD-10 Finland

Influenza due to identified zoonotic or pandemic influenza virus

3.8

7.3

R00.8

ICD-10 Finland

Other and unspecified abnormalities of heart beat

6.3

7.2

SPAT1215

SPAT

Assessment of need for medical rehabilitation

2.6

7.2

204

R01AD09

ATC

mometasone; nasal

1.4

7.2

393

3040

L17

ICPC

Foot/toe symptom/complaint

1.5

7.2

245

1722

M54.9

ICD-10 Finland

Dorsalgia, unspecified

1.9

7.2

102

557

Electrophysiological Special Examination

30.2

7.1

C01BA03

ATC

disopyramide; systemic

20.1

7.1

N05BA04

ATC

oxazepam; oral

1.5

7.1

244

1714

4930B

ICD-9 Finland

Asthma, Extrinsic asthma[EXTRINSIC ASTHMA CUM EXACERBATIONE]

8.0

7.1

SPAT1285

SPAT

Provision of consultation response

2.3

7.0

270

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

1.9

7.0

527

ZX120

NOMESCO Finland

Intravenous

1.9

6.9

520

UJF30

NOMESCO Finland

Ileoscopy through colon

1.9

6.9

521

A02BC03

ATC

lansoprazole; oral

1.5

6.9

305

2266

G43.1

ICD-10 Finland

Migraine with aura [classical migraine]

2.6

6.8

180

XG466

NOMESCO Finland

Sleep oxymetry

3.0

6.8

127

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

1.4

6.8

325

2446

M79.1

ICD-10 Finland

Myalgia

1.8

6.8

110

629

SAA03

NOMESCO Finland

Extended examination of mouth

1.4

6.8

336

2546

J44

ICD-10 Finland

Other chronic obstructive pulmonary disease

3.9

6.8

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

2.2

6.8

291

SPAT1281

SPAT

Other administrative function

2.0

6.8

444

349

Kela drug reimbursment

Febuxostat

40.3

6.8

DM1QA

NOMESCO Finland

Paranasal sinuses X-ray examination in one projection

2.5

6.8

193

J44.9

ICD-10 Finland

Chronic obstructive pulmonary disease, unspecified

2.3

6.7

251

GD1ED

NOMESCO Finland

Extensive high resolution CT examination of lungs

2.8

6.7

145

4120X

ICD-9 Finland

Old myocardial infarction[STATUS POST INFARCTUM CORDIS,MÄÄRITTELEMÄT]

4.7

6.7

D80.1

ICD-10 Finland

Nonfamilial hypogammaglobulinaemia

22.6

6.7

SPAT1058

SPAT

PEF monitoring instruction

1.9

6.6

483

K21.0

ICD-10 Finland

Gastro-oesophageal reflux disease with oesophagitis

1.8

6.6

105

597

TPH15

NOMESCO Finland

Insertion of central venous catheter through external or internal jugular vein

2.4

6.6

235

SAA01

NOMESCO Finland

Simple examination of mouth

1.4

6.6

651

5560

N06AX16

ATC

venlafaxine; oral

1.8

6.6

117

691

R03BC03

ATC

nedocromil; inhalant

2.0

6.6

404

Z01.1

ICD-10 Finland

Examination of ears and hearing

1.7

6.5

146

920

K21.9

ICD-10 Finland

Gastro-oesophageal reflux disease without oesophagitis

1.9

6.5

523

TFC10

NOMESCO Finland

Catheterisation of left atrium or ventricle

4.4

6.5

B01AC06

ATC

acetylsalicylic acid; oral (platelet aggregation inhibitors excl. heparin)

2.5

6.5

191

WX872

NOMESCO Finland

Intensive care

2.6

6.5

173

A01

ICPC

Pain general/multiple sites

2.0

6.5

380

I84.2

ICD-10 Finland

Internal hemorrhoids without complication

2.0

6.5

408

JN3AD

NOMESCO Finland

Abdominal CT examination

2.0

6.5

394

SPAT1236

SPAT

Informing family of child’s disability

3.3

6.5

WZC05

NOMESCO Finland

Specialty-specific consultation based on referral by dentist or doctor

2.4

6.5

222

J37.0

ICD-10 Finland

Chronic laryngitis

2.9

6.5

129

A28

ICPC

Limited function/disability NOS

1.6

6.5

162

1052

D07AB02

ATC

hydrocortisone butyrate; topical

1.5

6.5

272

1995

J47

ICD-10 Finland

Bronchiectasis

3.2

6.4

K04.5

ICD-10 Finland

Chronic apical periodontitis

1.5

6.4

235

1673

FPH96

NOMESCO Finland

Other removal of cardiac pacemaker or cardioverter-defibrillator

70.2

6.4

I45.6

ICD-10 Finland

Pre-excitation syndrome

70.2

6.4

E66.9

ICD-10 Finland

Obesity, unspecified

3.1

6.4

104

J40

ICD-10 Finland

Bronchitis, not specified as acute or chronic

3.1

6.4

104

J96.0

ICD-10 Finland

Acute respiratory failure

4.9

6.4

Z04.8

ICD-10 Finland

Examination and observation for other specified reasons

1.8

6.4

101

575

UKC02

NOMESCO Finland

Cystoscopy

1.5

6.3

201

1384

R28

ICPC

Limited function/disability (R)

5.2

6.3

H53.1

ICD-10 Finland

Subjective visual disturbances

2.3

6.3

247

4931A

ICD-9 Finland

Asthma, Intrinsic asthma[INTRINSIC ASTHMA SINE EXACERBATIONE]

5.5

6.3

FNA01

NOMESCO Finland

Anastomosis to coronary artery from internal mammary artery, one distal anastamosis

2.4

6.3

208

SPAT1081

SPAT

Cardiorespiratory global assessment

2.2

6.3

295

R10.1

ICD-10 Finland

Pain localized to upper abdomen

1.7

6.3

140

882

Initial installation of the atrial pacemaker

+∞

6.3

FPH10

NOMESCO Finland

Open removal of transvenous cardiac pacemaker or cardioverter-defibrillator

+∞

6.3

ATX

Other pacemaker replacement or related action, such as cord removal or replacement

+∞

6.3

342

Kela drug reimbursment

Dronedarone

+∞

6.3

C01BD07

ATC

dronedarone; oral

+∞

6.3

I34.9

ICD-10 Finland

Nonrheumatic mitral valve disorder, unspecified

+∞

6.3

FPE37

NOMESCO Finland

Implantation of biventricular cardioverter-defibrillator with atrial and ventricular electrodes

+∞

6.3

FPG30

NOMESCO Finland

Implantation of cardioverter-defibrillator with ventricular electrode

+∞

6.3

I45.8

ICD-10 Finland

Other specified conduction disorders

+∞

6.3

FFM10

NOMESCO Finland

Occlusion or excision of atrial appendage externally with a closing device

+∞

6.3

I20.01

ICD-10 Finland

Unstable angina

2.9

6.3

127

WX002

NOMESCO Finland

Sedation and analgesia

1.5

6.2

203

1409

J01DA09

ATC

[U] cefadroxil; inhalant, oral

1.5

6.2

260

1901

I20.80

ICD-10 Finland

Other angina pectoris no detected stenosis of coronary artery

4.1

6.2

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

1.7

6.2

130

804

R06AX27

ATC

desloratadine; oral

1.5

6.2

212

1488

D01AC20

ATC

imidazoles/triazoles in combination with corticosteroids; topical

1.5

6.2

241

1738

Single vessel balloon catheter extension

3.0

6.2

113

G45.0

ICD-10 Finland

Vertebro-basilar artery syndrome

2.8

6.2

136

R13

ICD-10 Finland

Dysphagia

2.0

6.1

354

N06AB10

ATC

escitalopram; oral

1.6

6.1

157

1026

L28

ICPC

Limited function/disability (L)

1.6

6.1

160

1053

G45.3

ICD-10 Finland

Amaurosis fugax

3.9

6.1

E86

ICD-10 Finland

Volume depletion

3.1

6.1

Z3226

NOMESCO Finland

Physiotherapist

1.6

6.1

180

1220

WYA30

NOMESCO Finland

Preparations for expected poor cooperation

2.0

6.1

360

WX000

NOMESCO Finland

Monitoring vital functions without anesthesy

2.6

6.1

162

J05AB01

ATC

aciclovir; systemic

1.5

6.0

188

1288

B01AB10

ATC

tinzaparin; parenteral

2.0

6.0

348

H90.3

ICD-10 Finland

Sensorineural hearing loss, bilateral

1.5

6.0

196

1359

K02

ICPC

Pressure/tightness of heart

3.3

6.0

TKC20

NOMESCO Finland

Catheterisation of bladder

1.9

6.0

420

NAME	I9_RBBB
CONTROL_EXCLUDE	I9_OTHHEART
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	I45[0-1]
HD_ICD_9	4264
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	I45[0-1]
COD_ICD_9	4264
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Parameter	HR [95% CI]	p-value
I9_RBBB	1.7 [1.49, 1.94]	< 0.001
Birth year	0.994 [0.99, 1.0]	0.141

Parameter	HR [95% CI]	p-value
I9_RBBB	1.463 [1.27, 1.69]	< 0.001
Birth year	0.986 [0.98, 1.0]	0.004

N-year risk	Females	Males
1	0.146%	0.279%
5	0.97%	1.671%
10	2.426%	4.319%
15	4.593%	8.042%
20	7.591%	13.486%

Right bundle-branch block

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints