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Crohn disease (strict definition, require KELA, min 2 HDR)

K11_CD_STRICT2

Crohn's disease: A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions

K11_KELACROHN
and K11_CROHNnumber of events
>1

2281

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K50
Hospital discharge: ICD-9 555
Hospital discharge: ICD-8 5630
Cause of death: ICD-10 K50
Cause of death: ICD-9 555
Cause of death: ICD-8 5630

2 out of 7 registries used, show all original rules.

2109

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Check minimum number of events None

2109

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Include endpoints None

2109

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Remove individuals based on genotype QC

2033

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K11_CD_STRICT2

Control definitions

Control conditions not K11_KELACROHN

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF3
Parent code in ICD-10 K50-K52
Name in latin Morbus Crohn

Summary Statistics

Key figures

All Female Male
Number of individuals 2033 1172 861
Unadjusted prevalence (%) 0.49 0.51 0.47
Mean age at first event (years) 40.26 39.45 41.36

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 1.83 [0.82, 4.10] 1.4e-1 68
15 years 0.01 1.66 [0.90, 3.05] 1.0e-1 34
5 years 0.00 1.91 [0.96, 3.78] 6.5e-2 14
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: K11_CD_STRICT2 – Crohn disease (strict definition, require KELA, min 2 HDR)
GWS hits: 9

Survival analyses between endpoints

Plot

before Crohn disease (strict definition, require KELA, min 2 HDR)
after Crohn disease (strict definition, require KELA, min 2 HDR)

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Crohn disease (strict definition, require KELA, min 2 HDR)