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Crohn disease (strict definition, require KELA, min 2 HDR)

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K11_CD_STRICT2

Crohn's disease: A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

  • K11_KELACROHN
  • and K11_CROHNnumber of events
  • >1
2773

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K50
  • Hospital discharge: ICD-9 — 555
  • Hospital discharge: ICD-8 — 5630
  • Cause of death: ICD-10 — K50
  • Cause of death: ICD-9 — 555
  • Cause of death: ICD-8 — 5630

2 out of 7 registries used, show all original rules.

2577

4. Check minimum number of events

None

2577

5. Include endpoints

None

2577

6. Filter based on genotype QC (FinnGen only)

2577

Control definitions (FinnGen only)

Control conditions
not K11_KELACROHN

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF3
Parent code in ICD-10
K50-K52
Name in latin
Morbus Crohn

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 12555 6354 6153
Only index persons 12138 6175 5963
Unadjusted period prevalence (%)
Whole population 0.18 0.18 0.17
Only index persons 0.23 0.23 0.23
Median age at first event (years)
Whole population 35.44 35.86 34.99
Only index persons 35.17 35.59 34.74

-FinnGen-

Key figures

All Female Male
Number of individuals 2577 1484 1093
Unadjusted period prevalence (%) 0.50 0.51 0.48
Median age at first event (years) 38.24 37.33 39.48

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
2272
Matched controls
22720
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L04AB04
ATC
adalimumab; parenteral
30.8
323.3
439
175
K50.9
ICD-10 Finland
Crohn disease, unspecified
460.8
323.0
1251
61
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
+∞
323.0
2272
420
L01BB02
ATC
mercaptopurine; oral
59.9
323.0
393
79
K50.1
ICD-10 Finland
Crohn disease of large intestine
389.3
323.0
1050
50
UJF32
NOMESCO Finland
Coloscopy
23.5
323.0
1730
2719
A07EA06
ATC
budesonide; oral, local oral
127.0
323.0
1364
265
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
128.5
323.0
411
39
UJF92
NOMESCO Finland
Capsular endoscopy
55.6
323.0
619
152
K50.0
ICD-10 Finland
Crohn disease of small intestine
785.8
323.0
1537
59
UJF30
NOMESCO Finland
Ileoscopy through colon
23.5
323.0
1171
982
A07EC02
ATC
mesalazine; oral, rectal
82.1
323.0
1505
531
L04AX01
ATC
azathioprine; systemic
84.8
323.0
1409
428
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
218.7
323.0
523
31
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
8.4
323.0
1330
3264
K50.8
ICD-10 Finland
Other Crohn disease
798.5
323.0
1536
58
H02AB06
ATC
prednisolone; systemic
5.8
323.0
1621
6786
K50
ICD-10 Finland
Crohn disease [regional enteritis]
336.3
294.0
292
10
JF1DG
NOMESCO Finland
Small bowel very extensive MRI with with high intensity magnet
169.9
272.9
283
19
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
5.3
264.2
1065
3238
P01AB01
ATC
metronidazole; oral, rectal
4.4
234.3
1365
5821
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
15.8
233.8
399
303
ZX120
NOMESCO Finland
Intravenous
7.5
208.3
548
927
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
13.5
203.4
371
324
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
6.7
191.0
548
1035
C10AC01
ATC
colestyramine; oral
18.6
173.0
274
166
J01MA02
ATC
ciprofloxacin; systemic
3.6
168.5
1140
5009
JF1BD
NOMESCO Finland
Very extensive small bowel CT
63.5
160.6
187
32
M07.4*K50.9
ICD-10 Finland
Arthropathy in Crohn's disease [regional enteritis]
247.3
158.4
161
7
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.3
154.4
1175
5526
A07EC01
ATC
sulfasalazine; oral, rectal
6.1
148.7
446
868
JFB20
NOMESCO Finland
Ileocaecal resection
108.5
140.0
152
15
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.1
135.9
1116
5377
H02AB07
ATC
prednisone; oral
4.5
135.0
550
1496
JN3BD
NOMESCO Finland
Extensive abdominal CT
5.3
132.4
456
1036
D94
ICPC
Chronic enteritis/ulcerative colitis
39.1
131.0
167
46
L04AC05
ATC
ustekinumab; parenteral
77.2
128.2
145
20
K51.5
ICD-10 Finland
Left sided colitis
10.0
122.8
258
288
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
9.0
122.1
273
340
4AA12
NOMESCO Finland
NA
67.7
121.5
140
22
A07EA02
ATC
hydrocortisone; rectal
12.4
116.0
217
192
WX002
NOMESCO Finland
Sedation and analgesia
3.5
111.1
619
2175
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
23.0
104.6
153
71
4AB02
NOMESCO Finland
NA
41.7
103.6
130
33
B03BA03
ATC
hydroxocobalamin; parenteral
8.3
99.9
233
308
JF1AD
NOMESCO Finland
Small bowel CT
43.7
99.8
124
30
A02BC02
ATC
pantoprazole; systemic
2.6
99.2
1526
9984
TPH04
NOMESCO Finland
Cathetrisation of vein
3.2
98.0
628
2417
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
20.5
96.1
146
76
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
10.9
94.0
187
186
K51.8
ICD-10 Finland
Other ulcerative colitis
14.6
93.7
162
119
JFB00
NOMESCO Finland
Partial resection of small intestine
20.2
92.6
141
74
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
3.6
85.0
441
1428
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
4.9
84.8
301
685
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
24.6
83.2
119
51
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.9
79.4
580
2388
K60.3
ICD-10 Finland
Anal fistula
10.9
74.6
147
143
M07.4
ICD-10 Finland
Arthropathy in Crohn disease [regional enteritis]
741.5
73.6
72
*
JH1CG
NOMESCO Finland
Extensive MRI of perianal area
32.6
73.4
97
31
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
5.1
71.2
243
526
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
18.8
68.1
106
59
JX1LA
NOMESCO Finland
Kinetic X-ray of alimentary tract with pictures
237.0
67.6
69
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.7
64.8
239
560
N02AX02
ATC
tramadol; systemic, rectal
2.2
64.5
959
5660
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
11.9
63.8
120
106
JHA00
NOMESCO Finland
Anal or perianal incision
10.8
57.2
113
110
JFA38
NOMESCO Finland
Endoscopic dilatation of small intestine
154.0
57.1
60
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.9
56.6
394
1536
B81
ICPC
Anaemia vit B12/folate deficiency
7.3
56.2
140
202
A06AC01
ATC
ispaghula (psylla seeds); oral
2.5
56.0
552
2630
JFA58
NOMESCO Finland
Endoscopic dilatation of colon
49.2
55.4
67
14
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.4
54.8
291
937
JFB21
NOMESCO Finland
Laparoscopic ileocaecal resection
143.4
53.1
56
*
N02BE01
ATC
paracetamol; systemic, rectal
2.3
52.9
1910
15768
K56.7
ICD-10 Finland
Ileus, unspecified
12.3
52.2
96
81
UJF02
NOMESCO Finland
Peroral enteroscopy
21.2
51.2
76
37
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
7.5
50.4
123
172
A02BC03
ATC
lansoprazole; oral
2.2
50.1
645
3472
3042
Kela drug reimbursment
NA
135.6
50.0
53
*
253
Kela drug reimbursment
NA
133.0
49.0
52
*
A02BC01
ATC
omeprazole; systemic
2.2
48.4
612
3260
K61.0
ICD-10 Finland
Anal abscess
8.0
47.6
111
145
107
Kela drug reimbursment
Pernicious anaemia
11.9
46.5
87
76
WX302
NOMESCO Finland
Thoracal epidural anesthesy
4.4
46.0
176
425
M45
ICD-10 Finland
Ankylosing spondylitis
6.2
45.6
127
214
Z01.8
ICD-10 Finland
Other specified special examinations
2.2
45.2
532
2728
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
45.1
662
3742
JFB33
NOMESCO Finland
Other resection comprising small intestine and colon
122.5
44.9
48
*
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.7
43.8
329
1329
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
4.5
42.0
156
365
3AC01
NOMESCO Finland
NA
11.7
41.5
78
69
JN3AD
NOMESCO Finland
Abdominal CT examination
3.4
41.5
214
669
4AA33
NOMESCO Finland
NA
50.0
40.8
49
10
56300
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Regional enteritis
89.7
39.9
44
5
R50.9
ICD-10 Finland
Fever, unspecified
2.5
39.8
362
1623
5550A
ICD-9 Finland
Regional enteritis, Small intestine
203.4
38.9
40
*
K83.0
ICD-10 Finland
Cholangitis
9.9
38.8
79
82
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
8.9
37.4
81
94
UJD02
NOMESCO Finland
Gastroscopy
4.3
37.0
144
353
JF1CM
NOMESCO Finland
Small bowel extensive MRI with with high intensity magnet
132.2
36.8
39
*
WW200
NOMESCO Finland
Immunization
4.7
36.8
131
294
D64.9
ICD-10 Finland
Anaemia, unspecified
3.2
36.3
206
690
A02BC05
ATC
esomeprazole; systemic
1.8
36.2
837
5500
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
4.3
35.4
138
339
JHD30
NOMESCO Finland
Incomplete incision of fistula-in-ano
31.3
34.8
46
15
JF1DM
NOMESCO Finland
Very extensive MRI of small bowel (more than 1.5 T)
58.1
34.3
40
7
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
3.3
34.3
183
586
WVA20
NOMESCO Finland
Medicine administration
5.9
32.9
94
164
JFB30
NOMESCO Finland
Right hemicolectomy
11.0
32.2
62
58
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
4.2
31.8
126
314
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.5
31.8
281
1232
J01DB01
ATC
cefalexin; oral
1.9
31.7
1852
15930
L04AA33
ATC
vedolizumab; parenteral
115.0
31.7
34
*
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.6
30.9
237
959
JAH00
NOMESCO Finland
Laparotomy
5.3
30.9
96
186
5552A
ICD-9 Finland
Regional enteritis, Small intestine with large intestine
68.9
29.9
34
5
UJF12
NOMESCO Finland
Enteroscopy through intestinal stoma
17.4
29.3
46
27
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
7.0
28.9
72
105
K59.1
ICD-10 Finland
Functional diarrhoea
3.4
28.9
147
454
A02BA02
ATC
ranitidine; systemic
2.1
28.8
366
1903
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.1
28.8
164
550
A05AA02
ATC
ursodeoxycholic acid; oral
5.7
28.0
82
148
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
2.9
28.0
179
646
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
8.9
28.0
60
69
J01MA12
ATC
levofloxacin; systemic
2.1
27.6
371
1967
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
5.0
27.2
89
183
NA6BG
NOMESCO Finland
Sacro-iliac joint MRI examination with high intensity magnet
5.5
26.7
80
149
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
3.8
26.4
114
308
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
26.4
533
3282
N02AJ06
ATC
codeine and paracetamol; systemic
1.7
26.1
817
5736
Z93.2
ICD-10 Finland
Ileostomy status
18.5
26.1
40
22
K92.1
ICD-10 Finland
Melaena
3.7
26.0
118
332
5551A
ICD-9 Finland
Regional enteritis, Large intestine
73.5
25.8
29
*
JHD33
NOMESCO Finland
Completing incision of fistula-in-ano
22.1
25.6
37
17
ZX112
NOMESCO Finland
Subcutaneous
5.5
25.1
75
139
M09.1*K50.9
ICD-10 Finland
Juvenile arthritis in Crohn's disease [regional enteritis]
+∞
25.0
24
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.8
24.8
460
2745
WX402
NOMESCO Finland
General anaesthesia
1.9
24.7
393
2221
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.9
24.5
377
2103
XJW99
NOMESCO Finland
Other investigative procedure on digestive system
22.2
24.3
35
16
JHD20
NOMESCO Finland
Incision of fistula-in-ano
8.0
24.2
55
70
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.5
23.7
199
844
C05AA08
ATC
fluocortolone; rectal, topical
2.1
23.3
301
1565
JH1CM
NOMESCO Finland
Perianal extensive MRI with 3 Tesla magnet
54.6
23.1
27
5
H02AB09
ATC
hydrocortisone; systemic
4.2
22.8
89
220
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
4.6
22.7
81
183
E0000UV
ATC
NA
1.6
22.6
845
6152
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
22.5
945
7085
D01
ICPC
Abdominal pain/cramps general
2.1
22.5
282
1446
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.9
22.2
356
2007
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
4.7
22.1
77
170
K63.1
ICD-10 Finland
Perforation of intestine (nontraumatic)
10.9
22.1
42
39
K29.7
ICD-10 Finland
Gastritis, unspecified
3.9
21.7
91
240
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.4
21.2
190
835
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
4.4
21.1
78
183
4AC05
NOMESCO Finland
NA
50.5
21.1
25
5
1370
FHL
Colonoscopy, whole colon
14.2
20.8
35
25
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
20.6
932
7064
Z98.0
ICD-10 Finland
Intestinal bypass and anastomosis status
14.5
19.9
33
23
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.4
19.8
173
750
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.6
19.8
809
5972
A07DA03
ATC
loperamide; oral
3.6
19.7
89
251
JAH01
NOMESCO Finland
Laparoscopy
2.9
19.6
122
433
UJH02
NOMESCO Finland
Anoscopy
3.1
19.6
109
361
J05AB11
ATC
valaciclovir; oral
2.0
19.3
277
1496
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.0
19.3
278
1503
K29.8
ICD-10 Finland
Duodenitis
8.4
19.2
42
51
K29.3
ICD-10 Finland
Chronic superficial gastritis
4.1
19.1
75
187
JFF13
NOMESCO Finland
Terminal enterostomy
26.3
19.1
26
10
JFG40
NOMESCO Finland
Revision of enterostomy or colostomy without laparotomy
18.3
19.1
29
16
JAP00
NOMESCO Finland
Freeing of adhesions in the peritoneal cavity
7.7
18.6
43
57
R19.8
ICD-10 Finland
Other specified symptoms and signs involving the digestive system and abdomen
6.5
18.6
48
75
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
4.6
18.4
64
142
K56.0
ICD-10 Finland
Paralytic ileus
9.0
18.1
38
43
K61.1
ICD-10 Finland
Rectal abscess
14.5
18.1
30
21
M05BA04
ATC
alendronic acid; oral
2.8
18.1
122
456
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
4.3
17.9
66
156
A03CA02
ATC
clidinium and psycholeptics; oral
2.9
17.8
108
379
D07AC01
ATC
betamethasone; topical
1.6
17.8
656
4699
JFA60
NOMESCO Finland
Stricturoplasty in small intestine
+∞
17.7
17
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
3.8
17.6
74
197
A06AC51
ATC
ispaghula, combinations; systemic
2.7
17.5
123
472
JFG50
NOMESCO Finland
Laparotomy with revision of enterostomy or colostomy
90.7
16.6
18
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.0
16.5
216
1125
A07AA09
ATC
vancomycin; oral
6.6
16.4
42
65
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
2.0
16.4
219
1150
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
16.3
1063
8565
B02.9
ICD-10 Finland
Zoster without complication
2.8
16.3
108
401
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
8.1
16.3
36
45
J02AC01
ATC
fluconazole; systemic
1.5
16.2
818
6255
WZC30
NOMESCO Finland
Teaching
1.9
16.1
257
1440
JAD30
NOMESCO Finland
Repair of incisional hernia using prosthetic material
6.0
16.0
44
75
H04.10
ICD-10 Finland
Dry eye syndrome
2.1
16.0
193
971
D07AB02
ATC
hydrocortisone butyrate; topical
1.6
15.8
556
3917
5559X
ICD-9 Finland
Regional enteritis, Unspecified site
+∞
15.6
15
*
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
3.0
15.4
89
304
K30
ICD-10 Finland
Functional dyspepsia
2.0
15.4
209
1104
M01AH01
ATC
celecoxib; oral (coxibs)
1.8
15.3
302
1815
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
3.7
15.2
66
182
JEA00
NOMESCO Finland
Appendectomy
2.2
15.1
162
775
H02AB04
ATC
methylprednisolone; systemic
1.8
15.0
283
1677
M46.1
ICD-10 Finland
Sacroiliitis, not elsewhere classified
4.5
15.0
53
121
WX110
NOMESCO Finland
Local anesthesy
1.4
14.8
1520
13253
E000001
ATC
NA
1.6
14.8
434
2915
JN2CG
NOMESCO Finland
Extensive MRI examination of lower part of abdoment with high intensity magnet
4.9
14.8
48
100
OAB74
NOMESCO Finland
Nutritional guidance related to treatment and rehabilitation for medical condition
7.2
14.8
35
49
L02.3
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of buttock
3.5
14.7
68
197
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
3.2
14.6
77
247
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
3.5
14.6
69
204
B01AB05
ATC
enoxaparin; parenteral
1.6
14.6
499
3486
R11
ICD-10 Finland
Nausea and vomiting
2.1
14.5
171
853
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.5
14.4
641
4744
K63.2
ICD-10 Finland
Fistula of intestine
19.2
14.2
21
11
D07XC01
ATC
betamethasone, combinations; topical
1.9
14.2
227
1272
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.4
14.0
121
523
WW500
NOMESCO Finland
Blood transfusion
3.0
13.9
82
284
D11
ICPC
Diarrhoea
1.8
13.9
273
1636
K65.0
ICD-10 Finland
Acute peritonitis
5.7
13.9
39
69
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.1
13.7
163
815
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.5
13.6
108
447
JF1CD
NOMESCO Finland
Extensive small bowel CT
75.6
13.6
15
*
J01AA02
ATC
doxycycline; systemic
1.4
13.5
1512
13267
D07AD01
ATC
clobetasol; topical
1.7
13.5
281
1716
K60.4
ICD-10 Finland
Rectal fistula
16.3
13.4
21
13
S18
ICPC
Laceration/cut
1.4
13.4
741
5714
ZJX00
NOMESCO Finland
Double balloon technique in gastroenterological endoscopy
18.3
13.4
20
11
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.2
13.2
130
601
K60.2
ICD-10 Finland
Anal fissure, unspecified
3.7
13.1
56
153
JFB46
NOMESCO Finland
Resection of sigmoid colon
7.9
13.1
29
37
D07AC13
ATC
mometasone; topical
1.5
13.0
545
3968
B03BA02
ATC
cyanocobalamin tannin complex; parenteral
13.1
12.9
22
17
D50.8
ICD-10 Finland
Other iron deficiency anaemias
4.6
12.8
44
98
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
3.9
12.8
52
136
D06BX01
ATC
metronidazole; topical
1.9
12.6
192
1058
K60.1
ICD-10 Finland
Chronic anal fissure
3.3
12.5
62
191
4AA17
NOMESCO Finland
NA
+∞
12.5
12
*
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
4.9
12.5
40
83
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.9
12.5
183
996
JFB96
NOMESCO Finland
Other partial excision of intestine
130.7
12.4
13
*
6403
FHL
Ileocal resection
130.7
12.4
13
*
M81.4
ICD-10 Finland
Drug-induced osteoporosis
13.2
12.4
21
16
D99
ICPC
Disease digestive system other
6.0
12.2
33
56
L40.0
ICD-10 Finland
Psoriasis vulgaris
2.4
12.1
100
421
J05AB01
ATC
aciclovir; systemic
1.5
12.0
402
2778
UJF14
NOMESCO Finland
Enteroscopy of ileoanal anastomosis
6.3
12.0
31
50
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.4
11.9
675
5209
L52
ICD-10 Finland
Erythema nodosum
7.1
11.8
28
40
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
2.3
11.8
104
455
UJK02
NOMESCO Finland
ERCP
3.7
11.5
49
134
JHW96
NOMESCO Finland
Other operation on anus or perianal tissue
9.3
11.5
23
25
K29.5
ICD-10 Finland
Chronic gastritis, unspecified
3.4
11.5
55
166
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.5
11.4
532
3946
M03BX02
ATC
tizanidine; oral
1.4
11.4
1249
10755
Z93
ICD-10 Finland
Artificial opening status
11.9
11.3
20
17
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
3.0
11.2
64
217
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
17.1
11.2
17
10
TPH07
NOMESCO Finland
Cathetrisation of artery
1.9
11.0
158
852
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.8
11.0
182
1031
J01DA01
ATC
[U] cefalexin; systemic
1.4
11.0
1263
10923
JFB01
NOMESCO Finland
Laparoscopic partial resection of small intestine
43.5
10.9
13
*
JFA96
NOMESCO Finland
Other local operation on intestine
43.5
10.9
13
*
L40.8
ICD-10 Finland
Other psoriasis
6.9
10.8
26
38
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
4.4
10.8
38
88
WX610
NOMESCO Finland
Patient controlled analgesia
6.1
10.7
28
46
SPAT1153
SPAT
Removal of sutures
1.4
10.7
526
3936
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.5
10.7
408
2899
L88
ICD-10 Finland
Pyoderma gangrenosum
21.6
10.7
15
7
K91.2
ICD-10 Finland
Postsurgical malabsorption, not elsewhere classified
21.6
10.7
15
7
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.0
10.6
132
673
1300
FHL
Esophagogastroduodenoscopy (also includes staining)
6.0
10.6
28
47
L04AD01
ATC
ciclosporin; systemic
3.2
10.5
54
172
SPAT1263
SPAT
Sampling
1.4
10.5
840
6840
UJG02
NOMESCO Finland
Proctoscopy
3.4
10.5
49
146
H20.1
ICD-10 Finland
Chronic iridocyclitis
5.1
10.5
32
64
UJF30
SPAT
NA
7.3
10.5
24
33
K55.9
ICD-10 Finland
Vascular disorder of intestine, unspecified
110.5
10.4
11
*
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
2.6
10.4
74
290
K85
ICD-10 Finland
Acute pancreatitis
4.0
10.4
40
101
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
2.5
10.4
77
309
UJF34
NOMESCO Finland
Left colonoscopy
7.7
10.4
23
30
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.6
10.4
324
2200
K02.1
ICD-10 Finland
Caries of dentine
1.3
10.3
1278
11129
M54.5
ICD-10 Finland
Low back pain
1.4
10.3
620
4808
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
2.4
10.3
89
387
6402
FHL
Small bowel resection
23.5
10.2
14
6
JFH20
NOMESCO Finland
Proctocolectomy and ileostomy
23.5
10.2
14
6
D82
ICPC
Teeth/gum disease
1.4
10.2
751
6025
K60.0
ICD-10 Finland
Acute anal fissure
3.8
10.2
41
108
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
1.6
10.2
261
1684
Z01.2
ICD-10 Finland
Dental examination
1.3
10.0
891
7368
K29.9
ICD-10 Finland
Gastroduodenitis, unspecified
5.3
10.0
29
55
A03FA02
ATC
cisapride; oral, rectal
2.0
9.9
121
615
N03AX16
ATC
pregabalin; oral
1.5
9.9
384
2734
B07.9
ICD-10 Finland
Verruca simplex
2.4
9.9
84
363
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.6
9.9
73
291
J01FF01
ATC
clindamycin; systemic
1.4
9.8
497
3730
R10.0
ICD-10 Finland
Acute abdomen
2.6
9.8
71
282
JFG00
NOMESCO Finland
Closure of loop enterostomy without resection
8.1
9.8
21
26
JFF10
NOMESCO Finland
Loop enterostomy
8.1
9.8
21
26
TQW99
NOMESCO Finland
Other minor procedure on skin
2.4
9.8
83
358
Z93.3
ICD-10 Finland
Colostomy status
7.0
9.8
23
33
J01FA10
ATC
azithromycin; systemic
1.3
9.8
1265
11046
JFB43
NOMESCO Finland
Left hemicolectomy
8.8
9.8
20
23
M07.5*K51.9
ICD-10 Finland
Arthropathy in ulcerative colitis
9.6
9.8
19
20
M81.9
ICD-10 Finland
Osteoporosis, unspecified
3.2
9.7
49
155
ZX114
NOMESCO Finland
Intramuscular
3.6
9.7
42
118
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.7
9.7
206
1265
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
3.2
9.6
49
156
6455
FHL
Perianal fistula surgery
9.1
9.5
19
21
R06AE07
ATC
cetirizine; oral
1.3
9.5
892
7416
K85.9
ICD-10 Finland
Acute pancreatitis, unspecified
3.2
9.5
47
147
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
4.1
9.4
35
86
SAA02
NOMESCO Finland
Basic examination of mouth
1.3
9.4
1455
13009
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
2.2
9.4
96
453
JN2DG
NOMESCO Finland
Very extensive MRI examination of lower part of abdoment with high intensity magnet
5.1
9.4
28
55
E86
ICD-10 Finland
Volume depletion
3.4
9.4
43
127
K59.9
ICD-10 Finland
Functional intestinal disorder, unspecified
3.8
9.3
38
102
JHA20
NOMESCO Finland
Excision of lesion of anal canal or perianal tissue
4.3
9.3
33
78
JFA70
NOMESCO Finland
Suture of small intestine
10.7
9.3
17
16
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.5
9.3
300
2051
M25.5
ICD-10 Finland
Pain in joint
1.4
9.2
526
4029
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.3
9.2
1140
9854
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.3
9.1
1067
9143
A03FA01
ATC
metoclopramide; systemic, rectal
1.5
9.1
341
2406
B01AB10
ATC
tinzaparin; parenteral
2.0
9.0
109
553
JK3MN
NOMESCO Finland
Bile absorbtion isotope examination
24.1
8.9
12
5
QBA10
NOMESCO Finland
Incision of skin of trunk
4.0
8.8
34
87
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.8
8.8
147
838
R4190
NOMESCO Finland
Nutritional therapy
2.3
8.7
81
366
K63.8
ICD-10 Finland
Other specified diseases of intestine
14.1
8.7
14
10
JGB30
NOMESCO Finland
Abdominoperineal excision of rectum
14.1
8.7
14
10
K85.3
ICD-10 Finland
Drug-induced acute pancreatitis
50.2
8.7
10
*
RD210
NOMESCO Finland
NA
2.8
8.6
55
203
M50.8
ICD-10 Finland
Other cervical disc disorders
8.2
8.6
18
22
A01AB09
ATC
miconazole; local oral
1.8
8.5
146
837
JFH10
NOMESCO Finland
Total colectomy and ileostomy
10.1
8.5
16
16
M13.9
ICD-10 Finland
Arthritis, unspecified
1.8
8.4
131
729
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
1.9
8.4
123
673
R51.80
ICD-10 Finland
Headache
1.5
8.3
302
2115
J01FA06
ATC
roxithromycin; oral
1.3
8.3
725
5929
S10
ICPC
Boil/carbuncle
2.0
8.3
106
549
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
1.6
8.2
192
1209
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
2.0
8.2
99
503
UKC02
NOMESCO Finland
Cystoscopy
1.6
8.1
207
1336
N32.1
ICD-10 Finland
Vesicointestinal fistula
17.2
8.1
12
7
N11.8
ICD-10 Finland
Other chronic tubulo-interstitial nephritis
11.7
8.1
14
12
56310
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Ulcerative colitis
10.1
8.0
15
15
6404
FHL
Hemicolectomy on the right
22.1
8.0
11
5
WX004
NOMESCO Finland
Patient-controlled sedation
7.2
8.0
18
25
L73.8
ICD-10 Finland
Other specified follicular disorders
4.0
7.9
30
76
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.8
7.9
139
803
A02BA03
ATC
famotidine; systemic
2.6
7.9
55
216
6451
FHL
Dilatation
7.8
7.9
17
22
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
4.1
7.9
29
72
TJF80
NOMESCO Finland
Ostomy education
4.7
7.8
25
54
56510
ICD-8 Finland
Anal fissure and fistula, Anal fistula
9.4
7.8
15
16
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
1.6
7.7
184
1163
T81.8
ICD-10 Finland
Other complications of procedures, not elsewhere classified
3.1
7.7
40
131
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
2.3
7.7
69
309
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
2.1
7.7
79
376
7200A
ICD-9 Finland
Ankylosing spondylitis and other inflammatory spondylopathies, Ankylosing spondylitis
7.4
7.7
17
23
S01FA02
ATC
scopolamine; ophthalmic
4.7
7.6
24
51
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
2.3
7.6
68
303
1380
FHL
Colonoscopy, left side
25.1
7.6
10
*
SPAT1325
SPAT
Vaccination
1.3
7.6
547
4340
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.5
7.5
249
1708
UJK12
NOMESCO Finland
Peroral cholangioscopy
8.9
7.5
15
17
A07AA02
ATC
nystatin; oral
2.0
7.5
94
485
M01AE01
ATC
ibuprofen; systemic, rectal
0.7
7.5
1744
18541
M05BB03
ATC
alendronic acid and colecalciferol; oral
3.9
7.4
29
76
K25.7
ICD-10 Finland
Gastric ulcer, Chronic without haemorrhage or perforation
5.0
7.4
22
44
XF400
NOMESCO Finland
ECG with 12 standard connections
1.5
7.4
243
1663
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.5
7.4
274
1930
K51
ICD-10 Finland
Ulcerative colitis
3.5
7.4
32
92
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.0
7.4
90
459
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
1.9
7.3
110
606
M01AH02
ATC
rofecoxib; oral
1.6
7.3
178
1135
4AB04
NOMESCO Finland
NA
+∞
7.3
7
*
K61.2
ICD-10 Finland
Anorectal abscess
10.9
7.3
13
12
H15.1
ICD-10 Finland
Episcleritis
3.2
7.3
35
109
M03BC51
ATC
orphenadrine, combinations; systemic
1.3
7.3
508
4004
N06AX21
ATC
duloxetine; oral
1.6
7.3
201
1325
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.3
7.3
609
4936
L73.2
ICD-10 Finland
Hidradenitis suppurativa
3.3
7.2
34
104
N06AX11
ATC
mirtazapine; oral
1.3
7.2
555
4437
K80.3
ICD-10 Finland
Calculus of bile duct with cholangitis
5.2
7.2
21
41
NA6CG
NOMESCO Finland
Sacro-iliac joint extensive MRI examination with high intensity magnet
5.2
7.2
21
41
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.3
7.2
1211
10749
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.7
7.2
148
901
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
3.9
7.2
27
69
JFB40
NOMESCO Finland
Resection of transverse colon
30.1
7.1
9
*
JHB30
NOMESCO Finland
Rubber band ligature of haemorrhoids or prolapse of mucosa
2.0
7.1
89
461
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
7.1
1523
13930
D06
ICPC
Abdominal pain localized other
1.7
7.1
152
936
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
4.2
7.1
25
60
M79.6
ICD-10 Finland
Pain in limb
1.3
7.1
621
5060
A02BX02
ATC
sucralfate; oral
2.4
7.1
59
254
D12.2
ICD-10 Finland
Benign neoplasm: Ascending colon
2.8
7.1
42
151
M79.7
ICD-10 Finland
Fibromyalgia
2.2
7.1
67
307
A07EC03
ATC
olsalazine; oral
8.8
7.0
14
16
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
3.7
7.0
28
76
R01AD12
ATC
fluticasone furoate; nasal
1.3
6.9
613
5000
K03.66
ICD-10 Finland
Tooth plaque
1.7
6.9
127
748
TPH05
NOMESCO Finland
Open cannulation of peripheral vein
5.2
6.9
20
39
EP1AE
NOMESCO Finland
Neck ultrasound examination
1.9
6.9
91
478
Z94.4
ICD-10 Finland
Liver transplant status
5.8
6.9
18
31
A06AD11
ATC
lactulose; oral
1.6
6.9
174
1121
K51.2
ICD-10 Finland
Ulcerative (chronic) proctitis
3.0
6.8
37
126
R2110
NOMESCO Finland
Giving the first information
1.7
6.8
133
799
D13.3
ICD-10 Finland
Benign neoplasm: Other and unspecified parts of small intestine
8.3
6.8
14
17
JWA00
NOMESCO Finland
Repair of wound dehiscence in gastroenterological surgery
8.3
6.8
14
17
JA3BT
NOMESCO Finland
Cathetrisation of abdominal cavity with X-ray guidance
8.3
6.8
14
17
M46.9
ICD-10 Finland
Inflammatory spondylopathy, unspecified
3.1
6.8
35
115
JKA20
NOMESCO Finland
Cholecystectomy
2.8
6.8
40
143
S01GX01
ATC
cromoglicic acid; ophthalmic
1.4
6.8
395
3025
K63.0
ICD-10 Finland
Abscess of intestine
16.7
6.7
10
6
N05CF02
ATC
zolpidem; oral
1.4
6.7
306
2238
I84.9
ICD-10 Finland
Unspecified hemorrhoids without complication
2.0
6.7
77
385
M01AX17
ATC
nimesulide; oral
1.4
6.7
345
2585
L57.0
ICD-10 Finland
Actinic keratosis
1.9
6.7
89
470
L04AB06
ATC
golimumab; parenteral
3.7
6.7
27
74
D12.5
ICD-10 Finland
Benign neoplasm: Sigmoid colon
2.3
6.6
56
242
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
2.3
6.6
56
243
J01CA04
ATC
amoxicillin; systemic
1.3
6.6
1765
16517
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
2.0
6.6
78
393
R05
ICD-10 Finland
Cough
1.4
6.6
307
2256
JJC00
NOMESCO Finland
Allogenic transplantation of liver
7.8
6.6
14
18
JN3DG
NOMESCO Finland
Very extensive MRI examination with high intensity magnet
5.5
6.6
18
33
D07BC01
ATC
betamethasone and antiseptics; topical
1.5
6.6
193
1289
5651A
ICD-9 Finland
Anal fissure and fistula, Anal fistula[FISTULA ANI]
8.7
6.5
13
15
K29.0
ICD-10 Finland
Acute haemorrhagic gastritis
8.7
6.5
13
15
JFB50
NOMESCO Finland
Other resection of colon
8.7
6.5
13
15
H22.1*M45
ICD-10 Finland
Iridocyclitis in ankylosing spondylitis
10.0
6.5
12
12
A02BB01
ATC
misoprostol; oral
6.9
6.5
15
22
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.8
6.5
112
647
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
4.5
6.5
21
47
N07BA03
ATC
varenicline; oral
1.8
6.5
110
633
D07AB08
ATC
desonide; topical
1.5
6.4
189
1265
L82
ICD-10 Finland
Seborrhoeic keratosis
1.5
6.4
206
1403
L20.0
ICD-10 Finland
Besnier prurigo
1.6
6.4
155
989
SPAT1255
SPAT
Intravenous administration of medicine
1.8
6.4
108
621
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
4.7
6.4
20
43
A07AA11
ATC
rifaximin; oral
14.3
6.4
10
7
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.2
6.4
60
276
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.4
6.3
315
2342
ULA02
NOMESCO Finland
Kolposcopy
1.6
6.3
177
1168
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
2.8
6.3
37
132
5609X
ICD-9 Finland
Intestinal obstruction without mention of hernia, Unspecified intestinal obstruction
11.0
6.3
11
10
M02.9
ICD-10 Finland
Reactive arthropathy, unspecified
3.0
6.3
33
111
WX290
NOMESCO Finland
Other blockade of nerve
1.3
6.3
996
8726
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.3
6.3
439
3454
JFC20
NOMESCO Finland
Other enterocolostomy
18.1
6.3
9
5
JGB96
NOMESCO Finland
Other proctectomy or excision of rectum
26.7
6.2
8
*
5586X
ICD-9 Finland
Other non-infective gastro-enteritis and colitis[KROONINEN INFLAMMATOORINEN SUOLISTOSAIRAUS, NUD]
26.7
6.2
8
*
M03BC01
ATC
orphenadrine (citrate); systemic
1.3
6.2
449
3551
JHD10
NOMESCO Finland
Myotomy of anal sphincter
5.0
6.2
18
36
T91
ICPC
Vitamin/nutritional deficiency
5.0
6.2
18
36
KH1AD
NOMESCO Finland
CT of urinary organs
2.2
6.2
59
275
A02BA04
ATC
nizatidine; systemic
1.8
6.1
100
568
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.2
6.1
1114
9906
B80
ICPC
Iron deficiency anaemia
2.5
6.1
44
178
JAD10
NOMESCO Finland
Repair of incisional hernia
4.7
6.1
19
41
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
4.9
6.0
18
37
E87.6
ICD-10 Finland
Hypokalaemia
2.5
6.0
44
180
U07.1
ICD-10 Finland
Emergency use of U07.1 | COVID-19, virus identified
1.3
6.0
391
3041

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
2374
10761
16.31
307.65
18.7
6.2
0.2
0.2
e9/l
7.38
2287
9599
1904
6753
7.97
307.65
15.3
6.1
—
—
—
0
0
2503
14958
24.45
307.65
22.5
7.0
73.2
75.9
u/l
4.18
2483
14135
436
96
54.46
307.65
4.0
3.6
8.5
8.5
mg/l
0.01
370
81
729
1557
6.13
307.65
7.0
4.4
0.1
0.1
%
1.73
199
408
694
1479
6.05
307.65
7.2
4.5
0.0
0.6
%
0.99
170
351
718
1495
6.27
307.65
6.5
4.1
0.3
0.6
%
3.33
168
331
2239
8119
14.40
307.65
4.5
2.2
73.0
73.9
nmol/l
0.89
2198
7472
753
1627
6.13
307.65
6.9
4.4
0.6
0.9
%
2.12
211
439
2360
10416
16.03
307.65
18.5
5.9
0.0
0.0
e9/l
1.21
2268
9127
2169
10189
8.13
307.65
18.5
6.0
28.2
29.3
%
6.60
2140
9594
2348
7602
24.50
307.65
11.2
4.8
37.0
36.5
g/l
6.25
2317
7112
390
86
53.26
307.65
3.1
3.2
155.0
96.4
au/ml
0.64
48
20
301
52
65.41
307.65
2.3
1.7
100.6
142.3
au/ml
—
36
7
2384
2872
98.48
307.65
8.7
2.3
204.6
111.5
ug/g
25.33
2326
2301
392
69
66.82
307.65
3.0
2.0
9.6
9.6
mg/l
0.01
332
55
2162
9812
8.47
307.65
18.7
6.3
8.7
8.4
%
9.03
2133
9268
2395
11878
15.39
307.65
20.1
9.0
3.9
4.0
e9/l
0.88
2312
10469
2137
9433
8.41
307.65
18.4
6.1
0.7
0.7
%
8.51
2108
8874
1757
2077
24.44
307.65
2.0
1.3
—
—
—
0
0
2357
10395
15.85
307.65
18.4
5.9
0.6
0.6
e9/l
0.08
2264
9115
2158
9749
8.46
307.65
18.3
6.0
2.6
2.8
%
6.56
2129
9140
1510
4625
6.47
307.65
4.7
2.1
2.7
2.8
mg/l
1.37
1426
3968
2163
10039
8.19
307.65
17.6
5.8
58.4
56.3
%
18.45
2132
9476
2365
10778
15.52
307.65
18.4
5.9
1.8
2.0
e9/l
5.01
2287
9635
948
3298
3.97
231.08
1.5
1.6
—
—
—
0
0
1482
6926
3.68
230.09
2.6
1.8
89.2
97.0
pmol/l
9.94
1078
3765
1765
9253
3.88
228.63
20.2
8.7
0.0
0.0
e9/l
0.57
1660
7595
1217
5055
3.67
226.32
13.4
4.3
—
—
—
0
0
2312
14916
6.35
217.59
9.1
3.8
11.9
9.9
mm/h
11.19
2250
13930
755
2326
4.18
216.94
2.8
2.5
21.6
24.3
%
5.38
681
2008
308
421
8.17
216.86
5.3
3.9
58.3
55.9
%
2.46
308
421
305
413
8.24
216.47
5.3
3.5
3.9
4.0
e9/l
0.39
305
413
796
2588
4.00
211.44
1.3
1.2
—
—
—
0
0
766
2527
3.89
197.73
2.8
2.4
2.4
2.4
g/l
0.49
738
2348
808
2768
3.80
197.25
2.9
2.4
13.0
14.2
umol/l
4.25
790
2563
1761
9803
3.52
194.61
4.5
2.8
97.4
104.2
ug/l
0.67
1712
9214
1745
9694
3.48
192.75
7.5
6.0
10.1
11.0
umol/l
4.35
1689
9205
1274
5940
3.26
187.96
4.9
2.5
56.4
56.7
u/l
0.12
1218
5508
1087
4816
3.17
171.52
1.6
1.7
—
—
—
0
0
170
9
202.09
165.01
2.9
2.4
2.9
4.2
mg/l
—
164
9
533
1642
3.83
148.15
4.1
2.4
0.2
0.2
g/l
3.60
518
1542
728
2757
3.29
146.49
2.1
1.7
1080.6
1176.7
nmol/l
2.04
549
2137
292
596
5.40
137.20
1.5
1.3
90.6
88.9
titre
0.03
32
63
442
1264
4.01
135.92
1.5
1.2
—
—
—
0
0
1408
7920
2.71
132.91
2.5
2.0
—
—
—
0
0
1299
7025
2.71
132.65
4.9
3.2
30.7
31.2
u/l
0.21
1222
6691
736
3008
3.03
127.73
1.6
1.4
566.3
505.3
titre
0.40
204
594
268
549
5.33
125.12
1.2
1.3
292.1
247.0
u/ml
1.34
162
328
72
17
43.54
120.54
1.1
1.4
41.7
19.6
u/ml
—
24
5
483
1619
3.44
116.11
2.2
2.7
11.1
10.5
g/l
2.53
446
1484
413
1269
3.68
113.36
1.8
1.8
1.2
1.3
g/l
1.06
393
1182
1450
8739
2.51
111.66
7.6
6.5
1.2
1.2
mmol/l
0.76
1246
7437
787
3579
2.73
109.42
2.5
1.6
412.2
31997821.2
pmol/l
3.32
724
3069
1347
7901
2.48
109.32
6.5
5.9
1.2
1.2
mmol/l
1.67
1245
7224
1109
6048
2.46
104.39
1.9
2.0
—
—
—
0
0
198
372
5.68
101.27
1.2
1.2
—
—
—
0
0
979
5138
2.46
99.16
12.9
6.7
—
—
—
0
0
2541
21346
14.63
96.59
31.6
11.5
14.2
21.7
mg/l
52.43
2373
16417
56
12
47.68
95.63
1.1
1.3
—
—
—
0
0
287
802
3.90
89.62
1.6
1.8
—
—
—
0
0
132
196
7.04
85.19
1.8
1.4
—
—
titre
—
0
0
319
991
3.53
85.01
1.3
1.3
—
—
—
0
0
877
4641
2.35
84.48
1.7
1.5
2.4
2.3
g/l
2.19
655
2940
851
4453
2.36
84.06
5.0
4.2
—
—
—
0
0
759
3786
2.42
83.49
1.7
1.5
21.0
20.4
nmol/l
0.34
697
3319
1128
6714
2.21
81.00
7.2
7.2
1.1
1.2
inr
5.43
402
2088
896
5119
2.15
68.76
4.5
3.9
7.4
7.4
ph
0.07
160
1008
111
173
6.66
68.36
1.5
1.3
128.0
196.3
titre
—
5
8
111
173
6.66
68.36
1.6
1.3
126.3
211.5
titre
0.65
35
34
105
161
6.76
65.66
2.6
3.5
58.8
53.6
%
1.24
60
120
2540
22480
10.05
64.14
31.5
12.7
74.7
73.7
umol/l
0.84
2540
22473
1837
13900
2.12
63.15
5.1
3.9
—
—
—
0
0
132
268
5.14
61.63
2.4
3.6
1.1
1.4
%
0.45
90
229
404
1744
2.56
58.70
3.8
3.0
1.8
1.8
%
0.34
371
1575
2537
22661
8.70
58.01
28.2
9.0
26.7
27.5
u/l
1.78
2529
21993
475
2240
2.37
56.79
3.9
3.0
6.0
7.5
umol/l
1.50
413
1939
830
4891
2.03
56.39
6.0
3.9
95.8
93.5
%
1.94
810
4769
241
824
3.12
54.21
1.8
1.6
5.2
9.7
u/ml
0.61
11
28
865
5269
1.97
52.76
4.6
3.6
0.0
0.0
estimate
1.49
434
1897
312
1248
2.71
52.60
2.6
3.0
73.9
73.3
e9/l
0.09
247
926
396
1790
2.43
51.71
4.3
3.5
—
—
—
0
0
446
2125
2.33
51.69
1.4
1.5
—
—
—
0
0
175
514
3.58
50.18
1.7
1.3
4.7
6.3
iu/ml
—
7
10
1395
10069
1.84
49.04
4.2
3.2
0.0
0.0
estimate
1.06
429
1874
1384
9977
1.84
48.73
5.2
4.4
0.0
0.0
estimate
0.50
439
1949
1382
9967
1.83
48.50
4.1
3.2
0.0
0.0
estimate
0.80
424
1894
141
367
4.01
48.12
2.0
1.7
0.7
0.8
g/l
0.31
111
285
848
5337
1.88
45.46
1.4
1.3
0.9
1.6
u/ml
2.04
217
1455
408
1982
2.26
44.70
2.0
2.1
336.2
375.5
nmol/l
4.18
379
1829
391
1880
2.27
43.85
3.3
2.5
41.2
63.7
u/l
0.42
354
1619
93
193
4.96
42.28
2.8
4.0
—
—
—
0
0
1479
11163
1.76
41.90
5.4
4.6
6.3
6.5
mmol/l
4.73
1410
10297
75
131
5.87
41.20
1.2
1.1
1524.9
1641.0
miu/ml
0.31
75
131
2368
20928
2.62
40.69
19.8
12.5
139.4
139.6
mmol/l
5.89
2323
20376
2159
18396
2.07
40.30
31.9
14.0
13.7
13.5
%
16.53
2153
18019
640
3806
1.91
40.04
2.8
2.5
6.0
6.8
e6/l
0.58
572
3353
2370
21006
2.60
39.51
20.0
12.5
3.9
3.9
mmol/l
18.03
2322
20408
1650
12993
1.75
38.83
4.8
3.9
257.9
754.4
e6/l
—
8
153
310
1422
2.34
38.57
2.9
2.7
4.4
4.1
e9/l
1.62
223
1187
190
687
2.91
38.47
1.6
2.0
1.5
1.4
g/l
0.08
165
608
847
5560
1.78
38.16
3.5
3.0
27.6
79.1
e6/l
2.31
705
4206
783
5065
1.78
36.83
3.6
2.9
0.5
0.4
e6/l
0.29
637
3753
479
2674
1.97
35.72
2.4
2.0
—
—
—
0
0
944
6483
1.72
35.71
3.0
3.0
21.1
43.6
ng/l
2.33
520
3736
111
303
3.78
35.39
1.1
1.1
1.5
1.5
g/l
0.19
105
272
776
5055
1.77
35.37
3.5
2.9
—
—
—
0
0
160
573
2.91
32.92
1.2
1.2
—
—
—
0
0
892
6140
1.69
32.80
3.1
2.3
—
—
—
0
0
331
1664
2.13
32.69
4.3
3.9
—
—
—
0
0
148
512
3.01
32.39
3.1
2.9
—
—
—
0
0
147
511
2.99
31.89
1.3
1.5
—
—
—
0
0
229
998
2.42
31.79
1.1
1.1
—
—
—
0
0
577
3539
1.81
31.74
3.0
2.6
543.9
555.9
mosm/kgh2o
0.55
506
3026
1065
7733
1.64
31.51
3.6
3.0
—
5.6
—
0
7
1251
9469
1.62
31.19
4.9
3.9
—
—
—
0
0
147
524
2.91
30.49
1.4
1.4
298.6
294.8
ug/g
0.07
75
292
947
6721
1.65
30.38
4.0
3.5
37.7
75.1
e6/l
2.23
743
4565
834
5741
1.67
30.09
3.7
2.8
—
—
—
0
0
858
5982
1.65
29.28
3.1
3.2
2.3
2.4
mmol/l
3.02
759
5367
409
2308
1.92
29.05
7.1
6.3
1.0
1.0
mmol/l
0.35
388
2160
703
4669
1.70
28.83
3.0
2.2
—
—
—
0
0
165
651
2.64
28.19
1.3
1.2
—
—
—
0
0
2443
22567
2.59
26.58
21.6
10.6
—
—
—
0
0
292
1518
2.04
26.12
8.2
8.4
8.1
8.3
mmol/l
0.27
281
1463
64
146
4.47
25.99
1.6
1.6
—
—
—
0
0
131
483
2.80
25.52
1.3
1.5
103.6
115.9
u/ml
0.54
30
93
471
2897
1.77
25.03
5.0
3.8
0.8
0.8
mmol/l
1.26
444
2740
142
565
2.60
23.84
4.3
3.7
40.0
2545.9
u/ml
0.79
119
479
158
663
2.47
23.74
1.8
1.7
0.2
0.2
g/l
0.22
153
619
159
686
2.40
22.48
1.8
1.7
1.2
1.2
g/l
0.09
154
640
2546
24278
5.05
21.95
41.7
16.9
276.6
255.9
e9/l
45.35
2538
23744
185
861
2.24
21.94
1.3
1.3
0.3
1.0
u/ml
1.25
18
76
167
745
2.33
21.89
1.3
1.2
—
—
—
0
0
391
2374
1.76
21.47
1.9
1.6
—
—
—
0
0
2546
24309
4.94
21.24
41.6
16.9
4.5
4.6
e12/l
23.08
2538
23732
2546
24318
4.90
21.04
41.7
16.9
6.8
6.7
e9/l
2.20
2539
23741
41
78
5.33
20.61
1.6
1.7
—
—
—
0
0
39
71
5.56
20.56
3.7
3.2
—
—
—
0
0
57
144
4.03
20.32
1.1
1.0
—
—
—
0
0
521
3481
1.62
19.84
1.3
1.2
8.9
10.3
u/ml
0.20
222
1435
1769
15263
1.51
19.80
4.7
3.0
45.1
42.8
u/l
0.56
1697
14523
139
601
2.39
19.56
2.0
2.1
2.2
1.6
ug/l
0.28
127
539
57
155
3.74
18.36
1.1
1.1
—
—
—
0
0
258
1446
1.87
18.32
3.7
3.2
—
—
—
0
0
537
3681
1.58
18.19
1.3
1.3
16.2
27.9
iu/ml
4.95
159
1121
307
1833
1.77
17.69
14.9
18.9
1.2
1.2
inr
0.37
56
292
460
3059
1.61
17.66
3.1
2.6
1.0
1.2
e6/l
0.37
287
1687
274
1586
1.81
17.52
5.1
4.3
—
7.4
—
0
8
267
1542
1.82
17.20
5.1
4.3
0.9
2.0
mmol/l
4.14
226
1245
370
2394
1.64
15.74
1.6
1.5
—
—
—
0
0
680
5054
1.47
15.40
2.9
2.6
—
—
—
0
0
425
2882
1.57
14.81
3.2
2.7
4.0
2.6
e6/l
0.92
256
1516
213
1209
1.83
14.48
4.2
4.2
87.0
81.3
ng/l
0.38
192
1095
367
2418
1.60
14.44
1.3
1.2
—
—
—
0
0
97
410
2.42
14.41
1.1
1.1
—
—
—
0
0
125
604
2.12
13.53
3.4
5.0
1.4
1.4
mg/l
0.35
119
569
245
1478
1.73
13.52
3.7
4.3
11.3
22.9
ug/l
0.65
190
1171
249
1516
1.71
13.29
7.0
7.8
1.2
1.4
mmol/l
1.27
235
1455
74
286
2.63
13.27
4.1
3.9
37.1
1110.9
u/ml
0.69
69
269
250
1542
1.69
12.71
1.4
1.4
—
—
—
0
0
90
395
2.32
12.33
1.1
1.1
—
—
—
0
0
580
4346
1.43
12.16
4.4
3.5
1.0
1.0
kg/l
0.42
100
591
163
900
1.87
12.10
6.2
4.7
23.4
24.2
mmol/l
2.48
158
824
236
1453
1.69
12.07
9.7
9.2
—
—
—
0
0
190
1101
1.78
12.06
3.5
3.5
5.0
5.2
kpa
3.32
175
1035
60
225
2.71
11.46
1.2
1.3
4.0
3.0
g/l
2.65
37
158
60
225
2.71
11.46
1.2
1.3
0.4
0.4
g/l
0.30
37
156
60
225
2.71
11.46
1.2
1.3
6.7
6.8
g/l
0.07
37
159
19
31
6.17
11.19
1.9
1.9
—
—
—
0
0
185
1090
1.75
11.09
3.5
3.5
7.4
7.4
ph
0.00
22
139
667
5193
1.38
11.06
2.0
2.2
132.3
246.9
u/l
3.40
645
4936
621
4778
1.39
11.05
3.3
3.3
—
—
—
0
0
587
4495
1.40
10.70
4.2
3.3
—
—
—
0
0
223
1397
1.65
10.67
3.6
3.6
1.2
1.2
mmol/l
0.04
195
1213
58
227
2.59
10.22
1.2
1.4
—
—
—
0
0
596
4630
1.37
9.85
1.8
1.8
1.0
1.0
mg/l
0.05
411
3403
620
4869
1.36
9.53
2.6
2.5
2822.2
4360.0
umol/l
0.63
565
4325
58
236
2.49
9.46
1.4
1.3
—
—
—
0
0
130
724
1.84
9.44
3.9
3.7
24.6
24.7
mmol/l
0.19
125
682
142
814
1.79
9.38
3.6
3.5
—
—
—
0
0
1794
16396
1.31
8.78
3.9
3.9
14.7
14.6
pmol/l
2.46
1646
15178
69
315
2.22
8.71
1.3
1.4
—
—
—
0
0
2068
19306
1.36
8.62
4.5
4.5
1.7
2.0
mu/l
1.91
1923
18100
52
214
2.46
8.32
1.8
2.8
0.9
1.2
e9/l
1.42
24
124
70
332
2.14
8.07
1.4
1.4
—
—
—
0
0
15
27
5.58
8.02
1.3
1.2
—
—
—
0
0
271
1894
1.48
8.00
1.2
1.2
—
—
—
0
0
189
1224
1.59
7.92
2.0
2.6
65.8
67.1
g/l
1.44
171
1139
86
445
1.96
7.85
2.9
2.3
10.0
5.6
umol/l
1.66
66
327
158
983
1.65
7.80
1.6
2.2
—
—
—
0
0
395
2977
1.39
7.70
3.0
2.9
2.4
2.4
mmol/l
0.10
338
2625
228
1557
1.51
7.54
1.3
1.3
150.1
234.1
u/ml
1.18
212
1444
15
29
5.20
7.45
4.3
8.1
35.8
46.8
ug/min
—
9
23
2187
20716
1.37
7.36
25.4
12.2
40.1
40.6
%
2.75
1619
16525
33
115
2.89
7.32
2.5
3.3
—
—
—
0
0
498
3945
1.33
6.98
2.4
3.0
891.2
1031.7
ng/l
0.40
416
3280
139
862
1.65
6.98
1.7
1.7
—
—
—
0
0
356
2680
1.38
6.96
2.2
2.3
29.8
29.7
s
0.21
348
2592
98
553
1.80
6.90
1.2
1.3
—
—
—
0
0
115
682
1.72
6.83
1.1
1.1
11.4
3.6
u/ml
0.41
15
101
76
398
1.94
6.75
3.8
3.3
33.3
34.2
umol/l
0.16
69
350
75
391
1.95
6.75
2.7
3.4
—
—
—
0
0
29
99
2.95
6.69
1.1
1.1
202.2
229.3
iu/ml
0.22
29
99
205
1418
1.48
6.39
2.4
2.4
7298.5
5626.5
u/l
0.27
61
559
419
3281
1.33
6.33
3.4
3.3
422.0
521.3
ng/l
0.13
255
2187
38
158
2.43
6.03
1.4
1.3
198724.1
75113.2
e6/l
0.30
26
109
38
159
2.41
5.96
2.8
3.1
—
—
—
0
0
722
8418
0.80
5.78
2.4
2.4
—
—
—
0
0
42
188
2.25
5.67
1.7
2.8
455.0
762.8
e6/l
2.76
26
72
116
729
1.62
5.58
3.4
3.3
0.7
0.7
%
0.41
116
700
74
412
1.82
5.51
2.1
1.7
7851.1
11137.0
e6/l
0.79
62
303
45
210
2.16
5.51
1.1
1.1
—
—
—
0
0
187
1314
1.46
5.41
1.3
1.4
—
—
—
0
0
35
150
2.35
5.24
1.5
1.5
33.9
33.9
%
0.00
23
95
117
749
1.59
5.24
3.4
3.3
1.4
1.4
%
0.20
117
742
92
559
1.67
5.08
1.4
1.3
2.3
3.2
u/ml
—
10
54
49
246
2.01
4.99
2.3
1.4
69.7
66.7
mmol/l
0.13
34
210
94
583
1.64
4.81
1.8
2.3
128.0
368.2
ug/l
2.18
80
542
179
1279
1.43
4.76
2.2
2.2
5.6
7.2
ug/l
0.47
152
1155
241
1825
1.35
4.55
9.9
8.3
12.4
12.9
kpa
0.95
231
1748
241
1825
1.35
4.55
9.9
8.3
5.0
5.1
kpa
2.11
231
1744
405
3299
1.27
4.49
1.6
1.4
—
—
—
0
0
14
40
3.51
4.33
1.6
2.3
—
—
—
0
0
239
1826
1.34
4.27
10.0
8.3
0.4
1.1
mmol/l
1.41
185
1422
35
165
2.14
4.25
1.4
2.2
10.3
12.2
%
0.38
15
89
123
837
1.49
4.24
2.0
2.3
—
—
—
0
0
83
517
1.63
4.22
2.6
2.4
—
—
—
0
0
40
200
2.02
4.17
1.3
1.6
51.1
57.8
%
0.44
24
131
39
196
2.01
4.03
2.5
2.8
—
—
—
0
0
204
1536
1.36
4.02
11.2
9.0
120.4
123.9
g/l
1.41
197
1479
20
75
2.68
3.99
1.4
2.0
—
—
—
0
0
66
394
1.69
3.97
2.0
3.3
1.2
1.5
ratio
—
5
37
44
234
1.90
3.88
1.4
1.4
—
—
nmol/l
—
0
0
54
307
1.78
3.86
1.6
1.6
—
—
—
0
0
118
813
1.47
3.86
2.2
2.4
21.9
21.2
s
0.29
103
707
126
1768
0.70
3.80
1.2
1.4
—
—
—
0
0
64
385
1.68
3.76
1.0
1.0
2.0
2.2
u/ml
0.12
19
190
31
147
2.12
3.74
1.0
1.3
—
—
—
0
0
66
402
1.66
3.70
2.0
3.3
34.8
38.6
mg/l
0.18
54
323
66
402
1.66
3.70
2.2
3.0
23.9
24.7
mmol/l
1.09
57
359
66
402
1.66
3.70
2.1
3.3
49.2
72.0
mg/l
0.60
54
322
67
410
1.65
3.69
3.4
3.6
2.4
2.2
mmol/l
0.22
48
255
24
104
2.32
3.59
1.3
1.4
38.6
66.9
%
—
5
14
211
1629
1.32
3.54
10.9
8.8
96.3
95.9
%
0.58
205
1569
76
486
1.58
3.53
3.3
3.5
7.4
7.4
ph
0.25
64
405
42
228
1.86
3.51
1.4
1.6
—
—
—
0
0
42
228
1.86
3.51
1.4
1.6
—
—
—
0
0
42
228
1.86
3.51
1.4
1.6
—
—
—
0
0
42
228
1.86
3.51
1.4
1.6
—
—
—
0
0
50
287
1.76
3.49
1.5
1.6
—
—
—
0
0
38
200
1.91
3.48
1.7
2.5
44.8
41.3
%
—
6
28
20
81
2.48
3.46
1.6
5.8
7413.0
71.7
mg/l
0.47
14
61
186
1415
1.34
3.46
1.3
1.3
59.2
53.3
au/ml
—
6
65
61
373
1.65
3.40
4.0
4.1
—
—
—
0
0
55
328
1.69
3.37
2.4
2.5
—
—
—
0
0
197
1520
1.32
3.33
2.5
2.3
19.4
23.5
au/ml
—
10
113
14
48
2.93
3.30
1.2
1.5
16.1
17.1
umol/l
0.40
14
41
77
504
1.54
3.26
1.9
1.6
1535.5
1439.7
e6/l
0.03
59
405
77
504
1.54
3.26
1.8
1.5
19.2
35.8
e6/l
0.49
55
390
73
473
1.56
3.23
1.7
1.6
—
—
—
0
0
141
1040
1.38
3.21
10.5
10.3
94.2
93.9
%
0.40
141
1035
96
661
1.47
3.20
2.5
3.4
0.3
0.3
g/l
0.12
43
300
22
97
2.28
3.19
1.1
1.1
—
—
—
0
0
135
992
1.38
3.15
10.0
7.6
24.4
24.5
mmol/l
0.11
125
921
18
73
2.48
3.12
1.2
1.3
—
—
—
0
0
10
29
3.46
3.04
2.1
1.4
—
—
—
0
0
80
537
1.51
3.04
10.8
6.6
1.2
1.2
mmol/l
0.28
64
460
27
133
2.04
3.01
1.1
1.1
—
—
—
0
0
20
87
2.31
3.00
2.5
4.6
—
—
—
0
0
117
852
1.39
2.91
1.5
1.7
—
—
—
0
0
7
13
5.40
2.87
1.0
1.1
—
—
—
0
0
50
306
1.65
2.83
1.2
1.3
—
—
—
0
0
14
53
2.65
2.79
1.6
1.4
33.1
49.1
%
0.80
14
48
7
204
0.34
2.79
8.4
14.2
593.0
819.6
nmol/l
—
7
198
90
631
1.44
2.78
5.1
4.9
—
—
—
0
0
7
14
5.01
2.73
1.0
1.1
—
—
—
0
0
2026
20914
0.85
2.71
3.9
4.2
2.7
2.9
mmol/l
19.61
1908
19674
61
397
1.55
2.70
1.4
1.4
21.5
19.6
u/l
0.21
51
338
19
86
2.22
2.63
1.2
1.1
—
0.0
g/l
—
0
5
53
336
1.59
2.63
3.6
3.2
—
—
—
0
0
15
61
2.47
2.62
3.6
2.4
—
—
—
0
0
11
38
2.90
2.58
1.2
2.9
—
—
—
0
0
9
25
3.61
2.57
1.0
1.1
—
—
—
0
0
44
268
1.65
2.56
1.5
1.4
0.2
0.4
nmol/l
—
6
16
1428
13479
1.13
2.56
3.2
3.2
—
—
—
0
0
90
642
1.42
2.55
10.9
8.3
—
—
—
0
0
41
248
1.66
2.46
1.6
1.5
73.5
42.5
mu/l
0.56
35
219
63
423
1.50
2.45
1.8
2.1
36.3
38.1
g/l
1.03
51
379
81
573
1.43
2.42
1.5
2.1
11.0
10.6
mg/l
0.17
74
538
11
40
2.76
2.37
1.6
3.3
—
—
—
0
0
134
1036
1.31
2.32
10.7
10.3
0.8
0.7
%
1.07
134
1031
40
245
1.64
2.31
2.1
1.7
—
—
—
0
0
43
269
1.61
2.29
1.5
1.4
0.7
0.6
nmol/l
0.60
43
258
5
9
5.56
2.21
1.0
1.2
—
—
—
0
0
79
569
1.40
2.17
4.3
4.2
1.3
1.4
mmol/l
0.37
79
560
133
1041
1.29
2.12
10.7
10.1
1.3
1.4
%
0.30
133
1036
44
283
1.56
2.11
2.6
2.7
—
—
—
0
0
2001
20584
0.88
2.10
3.7
3.8
1.4
1.4
mmol/l
4.35
1884
19401
17
82
2.08
2.06
1.2
1.1
32.8
426.3
ng/l
—
5
16
115
888
1.31
2.04
14.7
11.1
—
—
—
0
0
39
246
1.59
2.04
1.5
1.4
—
—
—
0
0
27
154
1.76
2.04
1.1
1.2
—
—
—
0
0
52
351
1.49
2.02
2.5
2.6
16.6
16.7
%
0.11
28
177
1924
19823
0.88
1.99
3.5
3.5
1.4
1.3
mmol/l
7.64
1806
18644
26
148
1.76
1.98
1.1
1.1
—
—
—
0
0
129
1018
1.28
1.96
8.2
5.4
—
—
—
0
0
5
11
4.55
1.94
5.2
1.7
—
—
—
0
0
152
1230
1.25
1.88
3.1
2.4
—
—
—
0
0
55
382
1.45
1.88
2.2
2.4
132.8
131.6
g/l
0.14
37
281
142
1143
1.26
1.85
2.1
2.8
150.1
154.5
ng/l
0.05
124
1019
719
6617
1.12
1.83
1.6
1.6
—
—
—
0
0
5
12
4.17
1.82
1.0
1.1
—
—
—
0
0
38
246
1.55
1.81
1.1
1.6
—
—
—
0
0
14
275
0.51
1.81
2.9
4.0
56.3
30.2
u/ml
0.43
14
270
27
161
1.68
1.78
1.1
1.2
—
—
—
0
0
108
846
1.29
1.76
11.7
11.0
23.5
24.4
mmol/l
1.93
101
804
29
177
1.65
1.76
1.3
1.2
—
—
—
0
0
17
88
1.94
1.74
1.3
1.7
—
—
—
0
0
45
306
1.48
1.73
1.9
3.5
—
—
—
0
0
13
61
2.14
1.71
2.0
2.6
59.4
90.1
ug/l
0.63
13
61
25
148
1.70
1.70
1.2
1.1
1.0
1.0
ratio
—
9
59
17
89
1.92
1.70
1.0
1.1
0.2
11.8
u/ml
0.69
11
51
50
349
1.44
1.69
3.5
3.8
—
—
—
0
0
26
156
1.67
1.69
1.2
1.1
—
—
—
0
0
84
640
1.32
1.69
1.3
1.1
—
—
—
0
0
40
267
1.51
1.68
3.6
2.9
7.3
7.2
mmol/l
0.04
40
259
6
19
3.16
1.66
1.2
1.4
—
—
—
0
0
266
3051
0.86
1.61
1.2
1.3
—
—
—
0
0
20
113
1.78
1.60
2.2
2.8
959.0
1060.5
u/ml
0.13
20
113
19
106
1.80
1.58
1.3
1.5
140.1
138.7
nmol/l
0.04
19
106
98
772
1.28
1.56
1.4
1.3
—
—
—
0
0
16
85
1.89
1.55
1.1
1.0
—
—
—
0
0
16
85
1.89
1.55
1.2
1.1
—
—
—
0
0
21
123
1.71
1.50
1.5
1.4
—
—
—
0
0
15
79
1.90
1.49
1.6
1.5
—
—
—
0
0
42
292
1.45
1.48
3.5
2.8
1.4
1.5
mmol/l
0.16
42
280
5
16
3.13
1.44
1.6
1.5
419.0
322.2
umol/24h
—
5
16
12
59
2.04
1.43
1.0
1.8
—
—
—
0
0
2024
20688
0.90
1.43
3.7
3.9
4.5
4.7
mmol/l
16.60
1907
19588
9
39
2.31
1.43
1.0
1.1
—
—
—
0
0
9
39
2.31
1.43
1.0
1.1
—
—
—
0
0
9
39
2.31
1.43
1.0
1.1
—
—
—
0
0
30
196
1.54
1.43
1.5
1.4
—
—
—
0
0
35
237
1.48
1.42
1.4
1.5
304.2
324.0
pmol/l
0.14
26
183
15
81
1.86
1.40
1.1
1.7
—
—
—
0
0
164
1388
1.19
1.38
3.3
3.3
4.6
4.6
pmol/l
0.25
146
1242
32
214
1.50
1.38
4.0
4.7
50.5
87.5
u/ml
0.39
12
62
5
121
0.41
1.37
3.2
2.3
131.0
154.5
nmol/l
—
5
105
6
23
2.61
1.36
6.7
6.3
3.5
6.7
mmol/l
—
6
23
114
932
1.23
1.36
1.4
1.5
7.1
8.1
u/l
0.51
94
769
125
1032
1.22
1.36
1.4
1.3
201.1
225.6
miu/ml
0.26
44
505
63
478
1.33
1.35
1.1
1.1
—
—
—
0
0
63
478
1.33
1.35
1.1
1.1
—
—
—
0
0
21
128
1.65
1.33
1.0
1.2
—
—
—
0
0
98
791
1.25
1.32
3.5
2.9
—
—
—
0
0
9
43
2.10
1.30
1.4
1.4
—
—
—
0
0
53
395
1.35
1.29
1.5
1.6
—
—
—
0
0
16
91
1.76
1.29
3.1
1.8
—
—
—
0
0
39
276
1.42
1.28
1.7
1.5
—
—
—
0
0
15
84
1.79
1.27
1.2
1.1
—
—
—
0
0
9
45
2.00
1.23
1.2
1.0
—
—
—
0
0
9
45
2.00
1.23
1.2
1.0
—
—
—
0
0
9
45
2.00
1.23
1.2
1.0
—
—
—
0
0
37
262
1.42
1.23
1.8
1.8
—
—
—
0
0
18
108
1.67
1.22
1.7
2.3
21.2
308.8
ug/l
0.68
18
97
11
56
1.97
1.22
1.5
1.2
—
—
—
0
0
11
56
1.97
1.22
1.3
1.2
—
—
—
0
0
21
132
1.60
1.20
2.1
2.6
769.6
614.5
ml
0.99
16
92
26
173
1.51
1.18
1.1
1.0
—
—
—
0
0
30
206
1.46
1.17
1.3
1.6
276.1
283.3
mosm/kgh2o
1.10
23
160
16
94
1.71
1.17
1.1
1.2
—
—
—
0
0
63
801
0.78
1.15
1.4
1.5
—
—
—
0
0
14
235
0.59
1.14
1.8
2.3
21.1
21.8
nmol/l
0.10
14
223
23
150
1.54
1.14
1.3
1.4
—
—
—
0
0
22
142
1.55
1.14
1.1
1.9
—
—
—
0
0
65
821
0.79
1.13
1.5
1.5
—
—
—
0
0
73
585
1.26
1.09
1.1
1.1
3.9
1.2
u/ml
0.42
29
259
157
1360
1.16
1.06
1.2
1.2
—
—
—
0
0
30
212
1.42
1.04
1.2
1.1
—
—
titre
—
0
0
50
385
1.30
1.03
1.2
1.2
—
—
—
0
0
9
47
1.92
1.02
2.0
2.0
—
—
—
0
0
64
797
0.80
1.01
1.4
1.5
—
—
—
0
0
7
35
2.00
1.00
1.4
1.1
3.1
3.4
mmol/l
—
7
30
0
29
0.00
0.97
0.0
1.1
—
—
—
0
0
0
30
0.00
0.97
0.0
3.0
—
44.0
—
0
23
35
468
0.74
0.96
1.4
1.3
2.4
3.7
ug/l
2.01
35
434
7
37
1.89
0.94
1.4
1.7
—
—
—
0
0
22
150
1.47
0.93
1.2
1.2
—
—
—
0
0
74
611
1.22
0.88
1.1
1.1
6.7
6.6
u/ml
0.01
33
339
79
657
1.21
0.88
1.1
1.1
0.3
1.7
u/ml
3.55
27
281
15
95
1.58
0.87
1.6
1.5
—
—
—
0
0
25
178
1.41
0.86
1.0
1.1
0.3
3.8
u/ml
—
8
58
6
31
1.94
0.84
1.3
1.0
—
—
—
0
0
8
46
1.74
0.82
1.0
1.1
—
—
—
0
0
6
115
0.52
0.82
2.0
2.5
46.2
50.3
umol/l
—
6
101
45
355
1.27
0.81
2.0
1.8
—
—
—
0
0
5
24
2.09
0.74
1.0
1.2
—
—
—
0
0
16
230
0.69
0.72
1.4
1.3
60.0
68.2
pmol/l
—
6
71
7
40
1.75
0.71
2.7
2.1
—
—
—
0
0
19
262
0.72
0.68
1.1
1.2
—
—
—
0
0
58
485
1.20
0.66
1.2
1.1
—
—
—
0
0
11
70
1.57
0.65
1.0
1.1
—
—
—
0
0
12
79
1.52
0.62
4.2
2.5
—
—
—
0
0
23
173
1.33
0.61
1.3
1.3
—
—
—
0
0
5
30
1.67
0.61
5.8
7.7
—
—
—
0
0
24
182
1.32
0.61
1.2
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
1.7
—
0
8
8
51
1.57
0.60
1.8
1.6
—
—
—
0
0
45
372
1.21
0.59
1.5
1.3
3.3
4.8
u/ml
0.78
24
168
589
5636
1.06
0.59
3.2
3.4
8.1
8.2
mmol/l
0.08
513
4854
113
1010
1.12
0.57
2.2
2.8
50.7
44.5
u/ml
0.13
107
975
22
167
1.32
0.56
1.1
1.0
—
—
—
0
0
50
420
1.19
0.56
2.2
1.9
—
—
—
0
0
23
176
1.31
0.56
1.2
1.3
0.1
0.7
u/ml
—
7
66
16
218
0.73
0.56
2.2
2.8
—
—
—
0
0
35
428
0.82
0.55
1.3
1.3
—
—
—
0
0
24
186
1.29
0.54
1.0
1.0
1.4
0.9
u/ml
—
6
48
9
60
1.50
0.54
2.4
2.2
—
—
—
0
0
20
151
1.33
0.54
2.8
2.4
—
—
—
0
0
9
63
1.43
0.52
1.4
1.4
—
—
—
0
0
149
1363
1.10
0.51
1.4
1.4
21.1
22.5
iu/l
0.25
127
1145
19
144
1.32
0.50
3.6
5.1
10.9
11.5
%
0.20
19
144
6
41
1.46
0.50
14.3
6.6
—
—
—
0
0
47
399
1.18
0.49
1.6
1.6
—
—
—
0
0
272
2891
0.93
0.49
2.5
2.7
0.6
0.7
ug/l
3.84
168
1680
110
1216
0.90
0.49
1.4
1.6
291.0
292.1
mu/l
0.01
98
1096
13
93
1.40
0.48
4.8
2.4
—
—
—
0
0
490
4698
1.05
0.47
3.3
3.4
307.0
316.8
mg/l
0.02
340
3058
15
111
1.35
0.46
1.1
1.3
—
—
—
0
0
112
1232
0.90
0.46
1.6
1.4
—
—
—
0
0
185
1723
1.08
0.44
1.2
1.2
90.8
150.8
iu/ml
1.13
51
654
10
69
1.45
0.44
4.1
3.0
—
—
—
0
0
12
163
0.73
0.43
1.7
3.4
—
—
—
0
0
496
5156
0.95
0.43
1.8
1.6
1.6
1.4
mmol/l
2.00
439
4449
379
3624
1.05
0.41
1.8
1.8
—
—
—
0
0
8
59
1.36
0.41
1.1
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.3
—
13.8
—
0
19
14
181
0.77
0.38
1.2
1.2
—
—
—
0
0
12
158
0.76
0.37
2.2
2.8
—
—
—
0
0
11
81
1.36
0.36
4.0
2.7
—
—
—
0
0
508
4914
1.04
0.35
4.1
4.1
13.1
9.3
mg/mmol
0.71
351
3206
64
575
1.12
0.35
1.0
1.1
4.9
2.6
u/ml
0.40
13
137
35
404
0.86
0.34
4.4
3.2
23.6
23.6
mg/l
0.00
15
247
508
4924
1.04
0.33
4.0
4.1
1.8
2.0
ug/l
1.03
471
4479
16
128
1.25
0.32
1.7
1.5
—
—
—
0
0
144
1531
0.94
0.30
1.7
1.6
—
—
—
0
0
7
54
1.30
0.30
1.3
1.1
—
—
—
0
0
238
2274
1.05
0.30
1.3
1.4
—
—
—
0
0
19
157
1.21
0.29
1.4
1.4
—
64.5
—
0
18
8
106
0.75
0.29
1.4
2.7
2175.9
2025.2
ml
—
8
97
8
107
0.75
0.29
1.5
1.4
68.9
73.3
%
—
8
102
116
1085
1.07
0.29
1.1
1.1
—
—
—
0
0
9
119
0.76
0.27
1.0
1.4
—
—
—
0
0
46
413
1.12
0.27
1.0
1.1
0.8
0.4
u/ml
—
10
95
10
128
0.78
0.26
1.1
1.0
—
—
—
0
0
19
159
1.20
0.26
1.6
1.5
5.7
6.4
mmol/l
1.38
14
113
9
72
1.25
0.25
1.2
1.2
—
—
—
0
0
1843
18289
1.03
0.24
4.5
4.8
37.2
38.5
mmol/mol
10.25
1730
17239
10
126
0.79
0.24
7.4
6.0
—
—
—
0
0
10
126
0.79
0.24
3.7
3.0
—
—
—
0
0
10
78
1.28
0.24
4.5
3.4
7.4
7.4
ph
—
5
21
14
115
1.22
0.23
1.4
2.2
1.0
2.1
u/field
—
7
62
5
38
1.32
0.23
1.2
1.2
2.9
5.5
nmol/l
—
5
38
13
106
1.23
0.23
1.5
1.5
—
—
—
0
0
41
371
1.11
0.22
1.2
1.2
—
—
—
0
0
52
477
1.09
0.22
1.0
1.1
4.3
3.9
u/ml
0.06
15
183
5
41
1.22
0.22
1.0
1.2
29.8
30.4
%
—
5
36
5
41
1.22
0.22
1.6
1.4
—
—
—
0
0
5
42
1.19
0.21
1.4
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
5.0
—
433.1
—
0
11
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
8
104
0.77
0.21
1.5
1.4
524.0
375.1
mu/l
—
8
99
5
43
1.16
0.21
1.4
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
11
89
1.24
0.21
1.4
1.3
—
—
—
0
0
251
2593
0.96
0.20
1.8
1.8
—
—
—
0
0
153
1597
0.96
0.20
2.1
2.3
—
—
—
0
0
25
221
1.13
0.20
1.3
1.4
10.0
12.5
mmol/l
—
5
47
20
174
1.15
0.19
1.0
1.0
0.1
3.8
u/ml
—
5
28
6
53
1.13
0.18
1.0
1.0
4.3
7.7
mg/g
—
6
53
7
63
1.11
0.17
1.1
1.2
—
—
—
0
0
155
1607
0.96
0.16
2.0
2.2
—
—
—
0
0
152
1575
0.96
0.16
2.0
2.3
—
—
—
0
0
156
1610
0.97
0.14
2.0
2.3
—
—
—
0
0
73
697
1.05
0.12
2.5
3.3
—
—
—
0
0
60
570
1.05
0.12
1.6
2.0
4.3
4.6
iu/l
0.08
18
220
41
434
0.94
0.10
1.4
2.7
0.9
0.8
nmol/l
0.23
36
374
42
397
1.06
0.10
1.2
1.2
—
—
—
0
0
35
372
0.94
0.10
1.1
1.1
28.3
1324.1
iu/ml
—
6
103
5
47
1.06
0.09
1.4
1.3
—
—
—
0
0
5
48
1.04
0.09
4.2
2.2
—
—
—
0
0
14
126
1.11
0.09
7.2
7.0
—
—
—
0
0
6
55
1.09
0.09
1.0
1.0
—
—
—
0
0
46
439
1.05
0.08
1.0
1.1
7.6
5.4
u/ml
0.24
17
178
8
74
1.08
0.07
1.0
1.3
—
—
—
0
0
49
471
1.04
0.07
1.4
1.5
0.5
0.4
nmol/l
0.39
40
385
16
147
1.09
0.07
1.6
2.7
38.7
44.2
%
—
5
43
7
82
0.85
0.07
1.7
1.4
—
—
—
0
0
9
102
0.88
0.06
1.8
1.8
—
9.3
—
0
10
9
104
0.86
0.06
2.3
1.6
1.0
1.3
nmol/l
—
9
86
26
246
1.06
0.06
2.7
1.8
—
—
—
0
0
13
119
1.09
0.06
1.7
1.4
20617.1
28880.8
e6/l
—
7
68
179
1816
0.98
0.06
2.2
2.2
12.6
12.9
nmol/l
0.21
164
1647
1966
19625
1.01
0.05
3.8
3.8
5.7
5.8
mmol/l
1.66
1827
18256
113
1111
1.02
0.05
2.6
3.4
—
—
—
0
0
25
262
0.95
0.04
2.4
2.3
—
—
—
0
0
147
1486
0.99
0.03
2.0
2.4
—
—
—
0
0
40
410
0.98
0.02
2.7
2.6
57.1
121.2
ug/min
1.20
25
256
15
158
0.95
0.02
1.4
1.2
—
—
—
0
0
20
207
0.97
0.01
3.1
3.1
0.7
0.8
nmol/l
0.67
11
163
14
134
1.05
0.00
1.6
1.4
3710.3
1910.6
e6/l
—
8
92
125
1244
1.01
0.00
2.0
2.5
—
—
—
0
0
10
101
0.99
0.00
2.2
2.9
—
—
—
0
0
20
201
0.99
0.00
2.4
1.6
1.4
1.3
promille
0.08
12
158
15
152
0.99
0.00
1.7
2.1
—
—
—
0
0
17
167
1.02
0.00
1.8
1.7
—
—
—
0
0
6
63
0.95
0.00
1.2
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
1273.0
—
0
5
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
5
49
1.02
0.00
1.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
36.9
—
0
6
0
6
0.00
0.00
0.0
1.2
—
2.7
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
3.3
—
1.9
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
69.1
—
0
7

Mortality – FinRegistry

↥

Association

Association between endpoint K11_CD_STRICT2 and mortality.

Females

Parameter HR [95% CI] p-value
K11_CD_STRICT2 1.165 [1.01, 1.34] 0.033
Birth year 0.998 [0.99, 1.01] 0.711

During the follow-up period (1.1.1998 — 31.12.2019), 291 out of 5295 females with K11_CD_STRICT2 died.

Males

Parameter HR [95% CI] p-value
K11_CD_STRICT2 1.13 [0.99, 1.29] 0.074
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 374 out of 5115 males with K11_CD_STRICT2 died.

Mortality risk

Mortality risk for people of age

years, who have K11_CD_STRICT2.

N-year risk Females Males
1 0.11% 0.199%
5 0.842% 1.372%
10 1.983% 3.277%
15 3.736% 6.183%
20 6.677% 10.509%

Relationships between endpoints

↥

Index endpoint: K11_CD_STRICT2 – Crohn disease (strict definition, require KELA, min 2 HDR)

GWS hits: 14

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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