No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly females |
293373 |
2. Check conditionsNone |
293373 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3376 |
4. Check minimum number of eventsNone |
3376 |
5. Include endpointsNone |
3376 |
6. Filter based on genotype QC (FinnGen only) |
3376 |
Control definitions (FinnGen only)
- Control exclude
- O15_DELIVERY
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF5
- Parent code in ICD-10
- O80-O84
- Name in latin
- Partus multiplex
Similar endpoints
↥List of similar endpoints to
Multiple delivery
based on the number of shared cases.
Similar with more cases:
- Delivery
- Delivery, wide proxy
- Pregnancy, childbirth and the puerperium
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 24092 | 24092 | - |
| Only index persons | 23570 | 23570 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.69 | 0.69 | - |
| Only index persons | 0.87 | 0.87 | - |
| Median age at first event (years) | |||
| Whole population | - | 30.31 | - |
| Only index persons | - | 30.31 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3376 | 3376 | - |
| Unadjusted period prevalence (%) | 1.15 | 1.15 | - |
| Median age at first event (years) | 30.45 | 30.45 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 3064
- Matched controls
- 30640
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
O84.8
ICD-10 Finland
Other multiple delivery
+∞
323.0
310
*
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
12.2
323.0
778
829
O84.0
ICD-10 Finland
Multiple delivery, all spontaneous
+∞
323.0
732
*
65000
ICD-8 Finland
Delivery without mention of complication, Occipital presentation
+∞
323.0
525
*
6500B
ICD-9 Finland
Delivery in a completely normal case[PARTUS SINE COMPLICATIONE]
+∞
323.0
502
*
6510B
ICD-9 Finland
Multiple gestation, Twin pregnancy[GEMINI, SYNNYTYKSEN AIKANA]
+∞
323.0
681
*
O80.0
ICD-10 Finland
Spontaneous vertex delivery
+∞
323.0
829
*
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
13.4
323.0
1033
1121
O30.0
ICD-10 Finland
Twin pregnancy
251.7
323.0
1297
89
Z39.2
ICD-10 Finland
Routine postpartum follow-up
13.8
323.0
592
524
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
38.4
323.0
688
229
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
12.5
323.0
713
725
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
18.8
323.0
523
331
65007
ICD-8 Finland
Delivery without mention of complication, Multiple pregnancy, all presentations
+∞
323.0
536
*
O84.2
ICD-10 Finland
Multiple delivery, all by caesarean section
+∞
323.0
529
*
O30.00
ICD-10 Finland
Twin pregnancy with separate amniotic and chorionic sacs
1061.2
300.0
289
*
MAX99
NOMESCO Finland
Assistance to normal delivery
67.3
272.7
315
52
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
15.4
260.8
448
337
SPAT1380
SPAT
Postpartum check-up
25.7
249.6
356
156
O60
ICD-10 Finland
Preterm labour and delivery
19.2
241.6
379
223
SPAT1197
SPAT
Extensive health check-up of expecting family
11.7
240.8
471
469
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
6.7
238.1
672
1226
SPAT1379
SPAT
Health check-up of pregnant person
13.1
230.3
425
373
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
13.4
215.3
392
332
O81.4
ICD-10 Finland
Vacuum extractor delivery
+∞
215.1
204
*
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
12.7
210.2
393
352
W84
ICPC
Pregnancy high risk
27.7
206.0
287
114
Z37.2
ICD-10 Finland
Twins, both liveborn
197.4
196.6
203
11
6510A
ICD-9 Finland
Multiple gestation, Twin pregnancy[GEMINI, RASKAUDEN AIKANA]
50.3
195.2
237
51
O82.10
ICD-10 Finland
Delivery by emergency caesarean section
661.3
191.1
187
*
MA2XE
NOMESCO Finland
Other obstetric ultrasound examination
12.6
183.8
343
303
W78
ICPC
Pregnancy
6.1
169.6
507
965
SPAT1196
SPAT
Monitoring of normal pregnancy
18.0
160.8
257
155
Z34.9
ICD-10 Finland
Supervision of normal pregnancy, unspecified
11.6
159.2
309
294
WX307
NOMESCO Finland
Obstetric epidural analgesia
13.5
150.8
271
218
XMA22
NOMESCO Finland
General examination of pregnant woman
13.2
141.0
256
210
O82.0
ICD-10 Finland
Delivery by elective caesarean section
+∞
136.5
130
*
Z32.1
ICD-10 Finland
Pregnancy confirmed
6.3
128.9
367
644
O68.0
ICD-10 Finland
Labour and delivery complicated by fetal heart rate anomaly
9.8
121.2
255
280
MAE00
NOMESCO Finland
Outlet vacuum delivery
13.5
120.6
216
171
O13
ICD-10 Finland
Gestational [pregnancy-induced] hypertension
11.8
117.9
225
204
Z34.0
ICD-10 Finland
Supervision of normal first pregnancy
6.2
112.2
322
567
MA2JE
NOMESCO Finland
Ultrasound screening of fetal nuchal translucency
6.3
111.4
318
556
Z35.0
ICD-10 Finland
Supervision of pregnancy with history of infertility
11.7
111.3
213
194
O32.1
ICD-10 Finland
Maternal care for breech presentation
9.6
109.0
232
259
65740
ICD-8 Finland
Occipital presentation
+∞
109.0
104
*
MAG00
NOMESCO Finland
Assisted breech delivery
165.9
107.0
112
7
O80.8
ICD-10 Finland
Other single spontaneous delivery
+∞
106.9
102
*
O36.5
ICD-10 Finland
Maternal care for poor fetal growth
19.6
106.4
164
88
O30.01
ICD-10 Finland
Twin pregnancy with a shared chorionic sac and a separate amniotic sac
1053.2
104.9
102
*
Z36.0
ICD-10 Finland
Antenatal screening for chromosomal anomalies
14.0
104.2
183
138
MA1AE
NOMESCO Finland
Ultrasound examination of early pregnancy (before 12. postmenstrual week)
4.3
101.3
416
1086
W90
ICPC
Uncompl labour/delivery livebirth
33.8
101.1
133
41
O42.9
ICD-10 Finland
Premature rupture of membranes, unspecified
20.6
101.0
153
78
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
5.5
77.5
244
476
O26.6
ICD-10 Finland
Liver disorders in pregnancy, childbirth and the puerperium
22.5
75.7
111
51
O80.1
ICD-10 Finland
Spontaneous breech delivery
+∞
73.2
70
*
SPAT1399
SPAT
Acceptance of acknowledgement of paternity of child born outside of marriage before the birth of the child at the maternity clinic. Paternity Act, Section 16.
17.1
72.6
117
71
65747
ICD-8 Finland
Multiple pregnancy, all presentations
+∞
71.1
68
*
O84.1
ICD-10 Finland
Multiple delivery, all by forceps and vacuum extractor
+∞
70.0
67
*
O47.1
ICD-10 Finland
False labour at or after 37 completed weeks of gestation
27.6
68.2
94
35
W85
ICPC
Gestational diabetes
9.2
66.9
144
163
SPAT1357
SPAT
Monitoring of problem during pregnancy
18.2
66.2
104
59
Z39.1
ICD-10 Finland
Care and examination of lactating mother
23.9
66.1
95
41
O26.82
ICD-10 Finland
Exhaustion and fatigue pregnancy-related
31.9
65.5
87
28
SPAT1317
SPAT
Planned health check-up monitoring, health check-up performed based on individual need
3.5
64.6
329
1017
6440A
ICD-9 Finland
Early or threatened labour, Threatened premature labour[PARTUS PRAEMATURUS IMMINENS]
8.0
62.3
146
190
O82.11
ICD-10 Finland
Childbirth with an emergency caesarean section in an emergency
+∞
61.7
59
*
O20.0
ICD-10 Finland
Threatened abortion
8.4
61.0
139
173
O72.1
ICD-10 Finland
Other immediate postpartum haemorrhage
17.2
60.6
97
58
SPAT1189
SPAT
Other ultrasound examination during pregnancy
15.7
59.7
99
65
Z35.2
ICD-10 Finland
Supervision of pregnancy with other poor reproductive or obstetric history
18.1
59.1
93
53
ZXD05
NOMESCO Finland
Urgent procedure
2.1
59.0
889
5055
G03GA01
ATC
chorionic gonadotrophin; parenteral
3.2
56.3
328
1115
63497
ICD-8 Finland
Other complications of pregnancy, Partus prematurus imminens, alibi non classificabilis
9.6
55.9
117
126
6440B
ICD-9 Finland
Early or threatened labour, Threatened premature labour[PARTUS PRAEMATURUS]
6.1
55.6
158
271
O26.88
ICD-10 Finland
Other specified pregnancy-related conditions
39.8
55.5
70
18
O20.9
ICD-10 Finland
Haemorrhage in early pregnancy, unspecified
9.1
55.0
119
136
Z35.9
ICD-10 Finland
Supervision of high-risk pregnancy, unspecified
10.5
54.8
109
107
MA5AE
NOMESCO Finland
Morphology ultrasound screening, weeks 18+0 to 21+6 of gestation
12.7
54.7
99
80
G02BA03
ATC
plastic IUD with progestogen
2.4
54.4
507
2297
O14.0
ICD-10 Finland
Mild to moderate pre-eclampsia
10.3
54.2
109
109
G03DA04
ATC
progesterone; systemic, rectal, vaginal
3.3
54.0
302
996
WX321
NOMESCO Finland
Acute spinal anesthesia for delivery
12.3
53.3
98
82
O72.0
ICD-10 Finland
Third-stage haemorrhage
12.8
53.2
96
77
Z37.0
ICD-10 Finland
Single live birth
4.0
50.9
217
574
O99.80
ICD-10 Finland
The fear of childbirth
6.5
50.2
135
215
Z35.4
ICD-10 Finland
Supervision of pregnancy with grand multiparity
107.8
48.9
53
5
O72.2
ICD-10 Finland
Delayed and secondary postpartum haemorrhage
16.1
48.9
80
51
SPAT1200
SPAT
Guidance for breast-feeding and breast care
20.4
48.0
72
36
G03AC03
ATC
levonorgestrel; systemic
2.4
47.5
434
1936
O42.0
ICD-10 Finland
Premature rupture of membranes, onset of labour within 24 hours
12.7
46.4
84
68
TMA00
NOMESCO Finland
Episiotomy
11.6
46.1
87
77
O34.3
ICD-10 Finland
Maternal care for cervical incompetence
28.7
45.7
62
22
Y6099
ICD-8 Finland
Prenatal care and observation
4.3
44.0
172
420
G03GA06
ATC
follitropin beta; parenteral
3.4
43.4
222
683
MA3AE
NOMESCO Finland
Combined first trimester screening
9.7
42.6
88
93
Z3232
NOMESCO Finland
Midwife
2.9
41.9
279
1033
Z36.4
ICD-10 Finland
Antenatal screening for fetal growth retardation using ultrasound and other physical methods
30.0
41.8
56
19
W92
ICPC
Compl labour/ delivery livebirth
10.5
41.4
82
80
O70.1
ICD-10 Finland
Second degree perineal laceration during delivery
15.8
41.4
68
44
Z30.2
ICD-10 Finland
Sterilization
2.4
40.6
377
1685
MAC01
NOMESCO Finland
Rupture of aminiotic membrane for induction of labor
12.6
40.4
73
59
MAC96
NOMESCO Finland
Other induction or advancement of labour
9.3
40.2
85
94
O64.1
ICD-10 Finland
Obstructed labour due to breech presentation
7.3
40.2
99
140
SPAT1190
SPAT
Insertion or removal of intrauterine contraceptive device
3.4
40.1
210
657
Z36.8
ICD-10 Finland
Other antenatal screening
16.2
40.0
65
41
O14.9
ICD-10 Finland
Pre-eclampsia, unspecified
13.5
39.9
70
53
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
11.6
39.9
75
66
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
11.8
39.7
74
64
O83.0
ICD-10 Finland
Breech extraction
+∞
38.6
37
*
MBA30
NOMESCO Finland
Manual removal of placenta from delivered uterus
11.7
38.5
72
63
O47.9
ICD-10 Finland
False labour, unspecified
22.0
37.0
54
25
MBC30
NOMESCO Finland
Repair of partial rupture of perineum
14.4
34.2
58
41
O36.8
ICD-10 Finland
Maternal care for other specified fetal problems
18.9
34.0
52
28
MBC10
NOMESCO Finland
Repair of obstetric laceration of vagina
18.9
34.0
52
28
Z34
ICD-10 Finland
Supervision of normal pregnancy
5.5
33.7
102
190
ZXD00
NOMESCO Finland
Emergency procedure
4.9
32.4
109
229
O80.9
ICD-10 Finland
Single spontaneous delivery, unspecified
+∞
32.3
31
*
MAC10
NOMESCO Finland
Antepartum dilatation of cervical canal
8.5
32.1
71
85
6522B
ICD-9 Finland
Malposition and malpresentation of foetus, Breech presentation without mention of version[PRAESENTATIO CLUNIUM,SYNNYTYKSEN AIKANA]
3.7
32.0
145
405
MBA03
NOMESCO Finland
Curettage of uterus after delivery or abortion
4.0
31.8
132
341
Z30.1
ICD-10 Finland
Insertion of (intrauterine) contraceptive device
2.1
31.3
407
2111
H01CA02
ATC
nafarelin; nasal
2.7
31.2
220
839
W29
ICPC
Pregnancy symptom/complaint other
9.3
30.6
64
70
O36.6
ICD-10 Finland
Maternal care for excessive fetal growth
6.9
30.4
77
114
8803
FHL
Stern exit
21.2
30.0
44
21
SPAT1375
SPAT
Structural ultrasound screening, weeks 18+0-21+6
107.7
29.7
32
*
O99.0
ICD-10 Finland
Anaemia complicating pregnancy, childbirth and the puerperium
18.2
29.2
45
25
G03GA02
ATC
human menopausal gonadotrophin; parenteral
2.7
29.0
205
785
O02.1
ICD-10 Finland
Missed abortion
2.8
28.9
192
707
WX306
NOMESCO Finland
Lumbar epidural anesthesy
2.5
28.8
234
971
O63.1
ICD-10 Finland
Prolonged second stage (of labour)
6.1
28.4
79
133
SPAT1316
SPAT
Extensive health check-up of children and adolescents
6.4
28.2
75
119
6511B
ICD-9 Finland
Multiple gestation, Triplet pregnancy[TRIGEMINI,SYNNYTYKSEN AIKANA]
+∞
28.2
27
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
0.3
27.9
66
2042
O35.8
ICD-10 Finland
Maternal care for other (suspected) fetal abnormality and damage
7.2
27.8
68
96
O21.0
ICD-10 Finland
Mild hyperemesis gravidarum
17.4
27.5
43
25
MAA00
NOMESCO Finland
Amniocentesis
5.6
27.3
81
148
O48
ICD-10 Finland
Prolonged pregnancy
8.6
27.0
59
70
SPAT1373
SPAT
Combined screening in early pregnancy
20.2
26.9
40
20
O26.7
ICD-10 Finland
Subluxation of symphysis (pubis) in pregnancy, childbirth and the puerperium
28.0
26.7
36
13
O46.9
ICD-10 Finland
Antepartum haemorrhage, unspecified
9.6
26.4
54
57
FM1QE
NOMESCO Finland
Extensive ultrasound of fetal heart
60.5
26.0
30
5
O69.0
ICD-10 Finland
Labour and delivery complicated by prolapse of cord
44.7
25.5
31
7
O21.9
ICD-10 Finland
Vomiting of pregnancy, unspecified
12.0
25.2
46
39
G03GB02
ATC
clomifene; oral
2.9
24.9
158
564
N81.6
ICD-10 Finland
Rectocele
3.0
23.9
139
470
N39.3
ICD-10 Finland
Stress incontinence
2.5
23.7
195
810
TMW99
NOMESCO Finland
Other minor surgical procedure in obstetrics
24.8
23.0
32
13
O03.9
ICD-10 Finland
Spontaneous abortion, Complete or unspecified, without complication
2.9
22.6
140
493
N81.2
ICD-10 Finland
Incomplete uterovaginal prolapse
3.5
22.3
108
320
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
1.8
22.2
398
2310
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
7.5
22.1
52
70
65006
ICD-8 Finland
Delivery without mention of complication, Complete or incomplete breech presentation
+∞
21.9
21
*
O30.9
ICD-10 Finland
Multiple gestation, unspecified
63.0
21.9
25
*
WX230
NOMESCO Finland
Plexus blockade of nervus pudendus
80.7
21.7
24
*
63230
ICD-8 Finland
Haemorrhage of pregnancy, Threatened abortion
4.7
21.6
74
160
MAG10
NOMESCO Finland
Breech extraction delivery
221.4
21.6
22
*
O41.0
ICD-10 Finland
Oligohydramnios
8.9
21.3
45
51
Z87.5
ICD-10 Finland
Personal history of complications of pregnancy, childbirth and the puerperium
23.3
21.2
30
13
WX320
NOMESCO Finland
Spinalanesthesy
1.7
21.2
517
3298
G03GA05
ATC
follitropin alfa; parenteral
2.5
21.2
167
681
O40
ICD-10 Finland
Polyhydramnios
14.7
21.1
35
24
N97.0
ICD-10 Finland
Female infertility associated with anovulation
3.2
21.1
111
351
MBA04
NOMESCO Finland
Curettage of uterus after delivery
37.4
20.8
26
7
Z32.0
ICD-10 Finland
Pregnancy, not (yet) confirmed
4.2
20.6
80
196
N81.1
ICD-10 Finland
Cystocele
2.9
20.6
129
457
O35.1
ICD-10 Finland
Maternal care for (suspected) chromosomal abnormality in fetus
4.6
20.4
72
161
6467A
ICD-9 Finland
Other complications of pregnancy, not elsewhere classified, Liver disorders in pregnancy[HEPATOSIS GRAVIDARUM]
7.2
20.3
49
69
SPAT1246
SPAT
Screening of depression or other psychiatric problem
3.0
20.2
121
415
O64.0
ICD-10 Finland
Obstructed labour due to incomplete rotation of fetal head
5.6
19.9
58
105
O42.1
ICD-10 Finland
Premature rupture of membranes, onset of labour after 24 hours
8.9
19.8
42
48
O02.0
ICD-10 Finland
Blighted ovum and nonhydatidiform mole
3.1
19.3
110
366
O91.2
ICD-10 Finland
Nonpurulent mastitis associated with childbirth
16.8
19.1
30
18
O68.8
ICD-10 Finland
Labour and delivery complicated by other evidence of fetal stress
18.3
19.1
29
16
O12.1
ICD-10 Finland
Gestational proteinuria
18.3
19.1
29
16
V252A
ICD-9 Finland
Contraceptive management, Sterilisation
2.0
19.1
243
1243
ZXE00
NOMESCO Finland
One hour or less
1.4
19.0
1075
8328
O85
ICD-10 Finland
Puerperal sepsis
20.2
19.0
28
14
O14.1
ICD-10 Finland
Severe pre-eclampsia
8.2
18.9
42
52
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.4
18.9
1547
12847
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
18.8
2102
18481
O83.1
ICD-10 Finland
Other assisted breech delivery
+∞
18.8
18
*
O10.0
ICD-10 Finland
Pre-existing essential hypertension complicating pregnancy, childbirth and the puerperium
6.1
18.7
51
85
SPAT1187
SPAT
General ultrasound examination in early pregnancy
17.2
18.7
29
17
O30.1
ICD-10 Finland
Triplet pregnancy
38.6
18.5
23
6
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
2.0
18.5
253
1330
Z39.0
ICD-10 Finland
Care and examination immediately after delivery
15.1
18.4
30
20
6526B
ICD-9 Finland
Malposition and malpresentation of foetus, Multiple gestation with malpresentation of one foetus or more[MONISIKIÖN YHT ESIINT VIRHETARJ,SYNNYTYKSEN AIKANA]
25.2
18.2
25
10
O86.0
ICD-10 Finland
Infection of obstetric surgical wound
11.1
18.2
34
31
SPAT1315
SPAT
Periodic health check-up of children and adolescents
3.9
18.1
75
196
MAC40
NOMESCO Finland
Pharmacological induction or advancement of labor
7.1
18.1
44
63
N97.9
ICD-10 Finland
Female infertility, unspecified
1.9
18.0
284
1573
N05AX08
ATC
risperidone; systemic
0.4
17.9
55
1516
W12
ICPC
Contraception intrauterine
1.9
17.9
296
1670
SPAT1195
SPAT
Antenatal classes
4.8
17.7
59
125
6400A
ICD-9 Finland
Haemorrhage in early pregnancy, Threatened abortion
4.9
17.7
58
121
O35.9
ICD-10 Finland
Maternal care for (suspected) fetal abnormality and damage, unspecified
12.5
17.6
31
25
WX234
NOMESCO Finland
Paracervical blockade
4.4
17.5
64
149
MBA00
NOMESCO Finland
Vacuum aspiration from uterus after delivery or abortion
3.4
17.1
83
248
SPAT1391
SPAT
Counselling and guidance related to family situation
9.8
16.6
33
34
SPAT1193
SPAT
Pap smear
1.7
16.5
360
2216
WX322
NOMESCO Finland
Combined spinal-epidural analgesia in obstetrics
8.6
16.4
35
41
O20.8
ICD-10 Finland
Other haemorrhage in early pregnancy
23.2
16.4
23
10
F20.9
ICD-10 Finland
Schizophrenia, unspecified
0.1
16.3
5
554
SPAT1263
SPAT
Sampling
1.4
16.3
1050
8273
LEF03
NOMESCO Finland
Posterior colporrpahy with sutures for primary rectocele
3.4
15.8
77
231
L02AE01
ATC
buserelin; implant, nasal, parenteral
2.8
15.7
102
373
O84.9
ICD-10 Finland
Multiple delivery, unspecified
+∞
15.6
15
*
O61.0
ICD-10 Finland
Failed medical induction of labour
6.7
15.5
39
59
Z36.9
ICD-10 Finland
Antenatal screening, unspecified
10.8
15.4
29
27
LEF00
NOMESCO Finland
Anterior colporraphy with sutures for primary cystocele
3.6
15.4
69
194
LGA20
NOMESCO Finland
Sterilisation by constriction of Fallopian tubes
6.7
15.2
38
57
O47
ICD-10 Finland
False labour
16.1
15.2
24
15
O44.1
ICD-10 Finland
Placenta praevia with haemorrhage
13.1
15.2
26
20
65400
ICD-8 Finland
Occipital presentation
0.1
15.1
9
613
N05AH03
ATC
olanzapine; systemic
0.4
15.1
63
1532
103
Kela drug reimbursment
Diabetes, insulin-treated
0.6
15.1
255
4032
A05AA02
ATC
ursodeoxycholic acid; oral
3.9
15.0
62
163
WYA40
NOMESCO Finland
Assessment of oral health and treatment needs for family expecting first child
8.1
15.0
33
41
N05AX12
ATC
aripiprazole; systemic
0.3
14.8
36
1099
O64.8
ICD-10 Finland
Obstructed labour due to other malposition and malpresentation
11.3
14.7
27
24
O28.3
ICD-10 Finland
Abnormal ultrasonic finding on antenatal screening of mother
18.4
14.7
22
12
6511A
ICD-9 Finland
Multiple gestation, Triplet pregnancy[TRIGEMINI,RASKAUDEN AIKANA]
80.5
14.6
16
*
215
Kela drug reimbursment
Diabetes, non-insulin-treated
0.6
14.5
252
3959
O73.0
ICD-10 Finland
Retained placenta without haemorrhage
9.4
14.4
29
31
ZXX02
NOMESCO Finland
Extent of procedure, 2 units
4.1
14.4
56
140
O24.9
ICD-10 Finland
Diabetes mellitus in pregnancy, unspecified
5.8
14.3
40
70
K42.9
ICD-10 Finland
Umbilical hernia without obstruction or gangrene
2.9
14.3
89
318
LCD10
NOMESCO Finland
Vaginal hysterectomy
2.7
14.1
95
354
F29
ICD-10 Finland
Unspecified nonorganic psychosis
0.3
14.1
31
993
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
14.1
990
7871
OAA12
SPAT
NA
14.5
14.0
23
16
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.3
14.0
1576
13507
SPAT1383
SPAT
Extensive health check-up at 4 years of age
10.1
13.9
27
27
O46.8
ICD-10 Finland
Other antepartum haemorrhage
53.6
13.8
16
*
J01DA01
ATC
[U] cefalexin; systemic
1.3
13.7
1769
15463
LGA10
NOMESCO Finland
Sterilisation by destruction or division of Fallopian tubes
5.6
13.7
39
70
LCA30
NOMESCO Finland
Transfer of oocyte or embryo to uterus in assisted fertilisation
4.6
13.7
47
104
W05
ICPC
Pregnancy vomiting/nausea
13.6
13.7
23
17
O62.1
ICD-10 Finland
Secondary uterine inertia
9.1
13.7
28
31
8221
FHL
Sterilization of the laparotomy pathway
2.5
13.7
108
444
MBA96
NOMESCO Finland
Other removal of retained products of conception after delivery or abortion
3.5
13.6
63
183
SAA02
NOMESCO Finland
Basic examination of mouth
1.3
13.5
1856
16364
O99.7
ICD-10 Finland
Diseases of the skin and subcutaneous tissue complicating pregnancy, childbirth and the puerperium
140.6
13.5
14
*
MA3AE
SPAT
NA
140.6
13.5
14
*
Z39
ICD-10 Finland
Postpartum care and examination
8.1
13.3
29
36
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
0.1
13.2
5
471
XMA20
NOMESCO Finland
Early examination of pregnancy
9.7
13.2
26
27
Z35
ICD-10 Finland
Supervision of high-risk pregnancy
6.4
13.2
34
54
G02CB01
ATC
bromocriptine; systemic
2.9
13.2
78
271
O12.0
ICD-10 Finland
Gestational oedema
15.1
13.1
21
14
O28.8
ICD-10 Finland
Other abnormal findings on antenatal screening of mother
16.8
13.0
20
12
MBA20
NOMESCO Finland
Expression of placenta
50.2
12.8
15
*
SPAT1303
SPAT
Counselling and guidance related to growth and development
10.5
12.7
24
23
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
0.1
12.6
*
378
Z36.1
ICD-10 Finland
Antenatal screening for raised alphafetoprotein level
70.1
12.6
14
*
O21
ICD-10 Finland
Excessive vomiting in pregnancy
11.0
12.5
23
21
SPAT1192
SPAT
Gynaecological examination
1.6
12.3
309
1971
I83.9
ICD-10 Finland
Varicose veins of lower extremities without ulcer or inflammation
1.7
12.3
239
1416
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.4
12.3
667
5044
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.3
12.3
1635
14248
N05AF03
ATC
chlorprothixene; systemic
0.2
12.3
14
637
63900
ICD-8 Finland
Other toxaemias of pregnancy and the puerperium, Pruritus
8.4
12.2
26
31
O75.0
ICD-10 Finland
Maternal distress during labour and delivery
9.0
12.2
25
28
O36.9
ICD-10 Finland
Maternal care for fetal problem, unspecified
12.4
12.1
21
17
N05AH02
ATC
clozapine; systemic
0.2
12.1
8
511
P72
ICPC
Schizophrenia
0.1
12.1
5
441
XMA00
NOMESCO Finland
NA
11.1
12.0
22
20
O44.0
ICD-10 Finland
Placenta praevia specified as without haemorrhage
8.7
12.0
25
29
K02.1
ICD-10 Finland
Caries of dentine
1.3
12.0
1592
13849
63499
ICD-8 Finland
Other complications of pregnancy, Other
4.0
11.8
46
116
SPAT1308
SPAT
Sexual health counselling
1.6
11.8
344
2279
63494
ICD-8 Finland
Other complications of pregnancy, Insufficientia cervicis
9.6
11.7
23
24
LEF13
NOMESCO Finland
Colpoperineoplasty and vaginal hysterectomy
3.4
11.7
55
163
O42.2
ICD-10 Finland
Premature rupture of membranes, labour delayed by therapy
16.4
11.7
18
11
O23.5
ICD-10 Finland
Infections of the genital tract in pregnancy
30.1
11.6
15
5
SPAT1188
SPAT
Monitoring of foetal growth
120.4
11.4
12
*
N71.0
ICD-10 Finland
Acute inflammatory disease of uterus
2.4
11.4
99
428
N03AG01
ATC
valproic acid; systemic, rectal
0.4
11.4
59
1319
N05AB03
ATC
perphenazine; systemic, rectal
0.3
11.4
27
835
63702
ICD-8 Finland
Pre-eclampsia, eclampsia and toxaemia, unspecified, Oedema
7.9
11.3
25
32
O36.4
ICD-10 Finland
Maternal care for intrauterine death
9.6
11.2
22
23
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.3
11.2
1333
11374
63496
ICD-8 Finland
Other complications of pregnancy, Labores inhibiti
6.8
11.1
27
40
SPAT1324
SPAT
Screening procedure
1.4
11.1
745
5832
O70.0
ICD-10 Finland
First degree perineal laceration during delivery
12.7
11.1
19
15
SGA01
NOMESCO Finland
Tooth opening as first aid
1.5
11.1
438
3105
N05BA06
ATC
lorazepam; systemic, sublingual
0.3
11.0
32
903
O32.2
ICD-10 Finland
Maternal care for transverse and oblique lie
10.1
11.0
21
21
Z25.8
ICD-10 Finland
Need for immunization against other specified single viral diseases
1.6
10.9
308
2027
MAC00
NOMESCO Finland
Rupture of amniotic membrane
43.4
10.9
13
*
Z76.0
ICD-10 Finland
Issue of repeat prescription
0.6
10.9
222
3381
O73.1
ICD-10 Finland
Retained portions of placenta and membranes, without haemorrhage
10.6
10.8
20
19
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.3
10.5
1092
9120
O75.6
ICD-10 Finland
Delayed delivery after spontaneous or unspecified rupture of membranes
6.5
10.5
26
40
MAE03
NOMESCO Finland
Mid-cavity or high vacuum delivery
14.2
10.5
17
12
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
0.2
10.4
9
481
65746
ICD-8 Finland
Complete or incomplete breech presentation
+∞
10.4
10
*
O86.1
ICD-10 Finland
Other infection of genital tract following delivery
16.1
10.3
16
10
WX290
NOMESCO Finland
Other blockade of nerve
1.3
10.3
1277
10914
J01CA04
ATC
amoxicillin; systemic
1.3
10.2
2343
21730
W94
ICPC
Puerperal mastitis
23.4
10.2
14
6
Z30.5
ICD-10 Finland
Surveillance of (intrauterine) contraceptive device
1.7
10.2
204
1221
NE1AG
NOMESCO Finland
MRI pelvimetry with high intensity magnet
6.2
10.1
26
42
LGA21
NOMESCO Finland
Laparoscopic sterilisation by constriction of Fallopian tubes
1.8
10.1
177
1016
LEG10
NOMESCO Finland
Vaginal urethrocystopexy
3.0
10.0
55
184
1412
FHL
Laparoscopy and sterilization
1.8
10.0
156
866
J01CA08
ATC
pivmecillinam; oral
1.3
10.0
1409
12235
N05AH04
ATC
quetiapine; oral
0.7
9.9
301
4247
XCK10
NOMESCO Finland
Photography of fundus of eye
0.5
9.9
77
1506
Z31.2
ICD-10 Finland
In vitrofertilization
3.5
9.9
44
126
SPAT1382
SPAT
Extensive health check-up at 18 months of age
10.6
9.8
18
17
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
0.3
9.7
27
774
N05AA02
ATC
levomepromazine; systemic
0.4
9.7
29
805
O31.8
ICD-10 Finland
Other complications specific to multiple gestation
55.1
9.6
11
*
O64.4
ICD-10 Finland
Obstructed labour due to shoulder presentation
55.1
9.6
11
*
N98.1
ICD-10 Finland
Hyperstimulation of ovaries
4.4
9.6
33
75
LAA10
NOMESCO Finland
Percutaneous or transvaginal puncture and recovery of oocyte
2.1
9.5
111
549
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
1.6
9.5
227
1428
O70.2
ICD-10 Finland
Third degree perineal laceration during delivery
10.0
9.5
18
18
SPAT1381
SPAT
Extensive health check-up at 4 months of age
15.1
9.5
15
10
N05CD07
ATC
temazepam; oral
0.6
9.4
109
1899
L02AE02
ATC
leuprorelin; implant, parenteral
2.3
9.4
83
363
O03.4
ICD-10 Finland
Spontaneous abortion, Incomplete, without complication
2.7
9.4
60
221
O43.0
ICD-10 Finland
Placental transfusion syndromes
30.1
9.4
12
*
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.3
9.4
1335
11570
PHD99
NOMESCO Finland
Resection of other vein
1.8
9.3
150
838
Z35.1
ICD-10 Finland
Supervision of pregnancy with history of abortive outcome
8.7
9.3
19
22
TLW00
NOMESCO Finland
Insemination
2.4
9.2
76
321
QBJ30
NOMESCO Finland
Correction of abdominal apron
3.3
9.2
44
134
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.3
9.1
1430
12526
O62.2
ICD-10 Finland
Other uterine inertia
11.5
9.1
16
14
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
8.3
9.1
19
23
63899
ICD-8 Finland
Hyperemesis gravidarum, Without mention of neuritis
9.0
9.0
18
20
A10AA01
ATC
NA
0.3
9.0
22
667
W18
ICPC
Post-partum symptom/complaint other
18.6
8.9
13
7
W99
ICPC
Disorder of pregn/delivery other
18.6
8.9
13
7
O21.1
ICD-10 Finland
Hyperemesis gravidarum with metabolic disturbance
24.1
8.9
12
5
U07.1
ICD-10 Finland
Emergency use of U07.1 | COVID-19, virus identified
1.4
8.9
501
3797
8811
FHL
Cesarean section
1.4
8.7
370
2657
G03GA04
ATC
urofollitropin; parenteral
2.7
8.7
59
224
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
0.3
8.7
22
658
W30
ICPC
Pregnancy, Medical examin/health eval complete
14.1
8.7
14
10
O67.9
ICD-10 Finland
Intrapartum haemorrhage, unspecified
50.1
8.7
10
*
G01AA10
ATC
clindamycin; vaginal
1.4
8.7
538
4138
LGA22
NOMESCO Finland
Hysteroscopic sterilisation
3.4
8.6
40
120
8502
FHL
Evacuation and abrasion
1.9
8.6
129
709
O34.1
ICD-10 Finland
Maternal care for tumour of corpus uteri
8.2
8.6
18
22
O32.0
ICD-10 Finland
Maternal care for unstable lie
11.6
8.6
15
13
O26.9
ICD-10 Finland
Pregnancy-related condition, unspecified
11.6
8.6
15
13
O63.0
ICD-10 Finland
Prolonged first stage (of labour)
2.9
8.6
50
175
W03
ICPC
Antepartum bleeding
6.9
8.5
20
29
H01CC01
ATC
ganirelix; parenteral
1.9
8.5
114
598
N05CF01
ATC
zopiclone; oral
0.8
8.5
554
6937
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
0.3
8.5
13
496
F25.9
ICD-10 Finland
Schizoaffective disorder, unspecified
0.1
8.4
*
319
64399
ICD-8 Finland
Spontaneous abortion, Without mention of sepsis or toxaemia
2.3
8.4
74
327
XMA02
NOMESCO Finland
Fetal heart ultrasound examination
+∞
8.3
8
*
O31.2
ICD-10 Finland
Continuing pregnancy after intrauterine death of one fetus or more
+∞
8.3
8
*
O45.9
ICD-10 Finland
Premature separation of placenta, unspecified
10.8
8.3
15
14
W27
ICPC
Fear of complications of pregnancy
7.1
8.2
19
27
6282B
ICD-9 Finland
Infertility, female, Of tubal origin[STERIL ET INFERT EX ORIG TUBAE UTERINAE SEC]
3.9
8.2
32
83
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
2.0
8.2
95
474
N97.4
ICD-10 Finland
Female infertility associated with male factors
2.2
8.2
83
391
A10AA02
ATC
NA
0.4
8.2
25
684
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
7.5
8.1
18
24
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.3
8.1
1028
8735
Z30.0
ICD-10 Finland
General counselling and advice on contraception
1.6
8.0
194
1228
67008
ICD-8 Finland
Sepsis of childbirth and the puerperium, Alia definita
6.3
8.0
20
32
O04.9
ICD-10 Finland
Medical abortion, complete or unspecified, without complication
1.5
8.0
282
1954
N05BA01
ATC
diazepam; systemic, rectal
0.7
8.0
189
2797
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.3
7.9
892
7460
205
Kela drug reimbursment
Chronic hypertension
0.7
7.8
204
2957
N05AF05
ATC
zuclopenthixol; systemic
0.0
7.7
*
193
O32.5
ICD-10 Finland
Maternal care for multiple gestation with malpresentation of one fetus or more
45.1
7.7
9
*
W28
ICPC
Limited function/disability (W)
45.1
7.7
9
*
MBC20
NOMESCO Finland
Repair of obstetric laceration of vulva
15.0
7.7
12
8
N92.0
ICD-10 Finland
Excessive and frequent menstruation with regular cycle
1.4
7.6
354
2587
V230A
ICD-9 Finland
Supervision of high-risk pregnancy, Pregnancy with history of infertility
3.1
7.6
40
132
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.3
7.6
649
5228
63501
ICD-8 Finland
Urinary infections arising during pregnancy and the puerperium, Pyelitis et pyelocystitis
11.9
7.6
13
11
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.3
7.6
700
5706
6441A
ICD-9 Finland
Early or threatened labour, Other threatened labour
3.8
7.5
30
80
6488A
ICD-9 Finland
Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Abnormal glucose tolerance
2.5
7.4
53
211
OAA11
SPAT
NA
2.7
7.3
48
182
KMAK
NOMESCO Finland
NA
1.2
7.3
1498
13394
O30
ICD-10 Finland
Multiple gestation
+∞
7.3
7
*
65004
ICD-8 Finland
Delivery without mention of complication, Occipital presentation, posterior position
+∞
7.3
7
*
MAC98
NOMESCO Finland
Other induction of labor
+∞
7.3
7
*
FM1NE
NOMESCO Finland
Ultrasound examination of fetal heart
9.4
7.3
14
15
N05AA01
ATC
chlorpromazine; systemic, rectal
0.1
7.3
*
289
MA4AT
NOMESCO Finland
Chorion biopsy with ultrasound guidance
4.4
7.1
24
55
M62.0
ICD-10 Finland
Diastasis of muscle
7.9
7.1
15
19
TAB22
NOMESCO Finland
Stoppin epidural fluid escape with coagulated blood
3.0
7.1
38
128
Z29
ICPC
Social problem NOS
2.8
7.1
43
157
J01AA02
ATC
doxycycline; systemic
1.2
7.0
2215
20713
LA2AE
NOMESCO Finland
Ultrasound examination of ovarian cyst
1.9
6.9
91
478
H04AA01
ATC
glucagon; nasal, parenteral
0.3
6.9
15
476
188
Kela drug reimbursment
Psychosis requiring demanding treatment
0.2
6.8
5
294
N05AD01
ATC
haloperidol; systemic
0.3
6.8
12
428
O36.3
ICD-10 Finland
Maternal care for signs of fetal hypoxia
6.7
6.8
16
24
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
2.7
6.8
44
166
OAB42
SPAT
NA
0.4
6.7
34
764
WX110
NOMESCO Finland
Local anesthesy
1.2
6.7
1919
17697
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
0.5
6.7
45
916
LAA06
NOMESCO Finland
Transvaginal puncture of ovarian cyst
3.0
6.7
36
122
SGB30
NOMESCO Finland
Other demanding filling of root channel of tooth
1.4
6.4
302
2214
JAF10
NOMESCO Finland
Repair of umbilical hernia
2.9
6.4
37
129
SGC10
NOMESCO Finland
Covering pulpa of tooth
1.5
6.4
240
1682
Z35.6
ICD-10 Finland
Supervision of very young primigravida
70.0
6.4
7
*
O30.02
ICD-10 Finland
Twin pregnancy with a shared amniotic and chorionic sac
70.0
6.4
7
*
N04AA02
ATC
biperiden; systemic
0.3
6.4
12
414
O36.0
ICD-10 Finland
Maternal care for rhesus isoimmunization
14.3
6.4
10
7
Z35.7
ICD-10 Finland
Supervision of high-risk pregnancy due to social problems
14.3
6.4
10
7
PHD76
NOMESCO Finland
Resection of long saphenous vein
1.8
6.3
102
574
O28.1
ICD-10 Finland
Abnormal biochemical finding on antenatal screening of mother
8.2
6.3
13
16
G01AF05
ATC
econazole; vaginal
1.4
6.3
273
1973
N05AN01
ATC
lithium; oral
0.4
6.3
20
537
Z36
ICD-10 Finland
Antenatal screening
+∞
6.2
6
*
O90.1
ICD-10 Finland
Disruption of perineal obstetric wound
+∞
6.2
6
*
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
0.1
6.2
*
214
G03HB01
ATC
cyproterone and estrogen; systemic
0.7
6.2
283
3745
Z16
ICPC
Relationship problem with child
7.0
6.2
14
20
O99.5
ICD-10 Finland
Diseases of the respiratory system complicating pregnancy, childbirth and the puerperium
6.3
6.2
15
24
B02AA02
ATC
tranexamic acid; systemic
1.3
6.1
514
4123
W19
ICPC
Lactation symptom/complaint
7.7
6.1
13
17
MBC33
NOMESCO Finland
Repair of complete rupture of perineum
7.7
6.1
13
17
N06AX11
ATC
mirtazapine; oral
0.8
6.1
650
7721
SPAT1228
SPAT
Forms of educational rehabilitation therapy
12.5
6.1
10
8
O90.9
ICD-10 Finland
Complication of the puerperium, unspecified
12.5
6.1
10
8
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
0.5
6.0
33
718
SPAT1301
SPAT
No procedures
1.3
6.0
655
5432
N03AX09
ATC
lamotrigine; oral
0.6
6.0
71
1225
Mortality – FinRegistry
↥Association
Association between endpoint O15_DELIV_MULTIP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| O15_DELIV_MULTIP | 0.493 [0.37, 0.66] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.635 |
During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 11349 females with O15_DELIV_MULTIP died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have O15_DELIV_MULTIP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.072% | No data |
| 5 | 0.323% | No data |
| 10 | 0.778% | No data |
| 15 | 1.496% | No data |
| 20 | 2.772% | No data |
Relationships between endpoints
↥Index endpoint: O15_DELIV_MULTIP – Multiple delivery
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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