Intrahepatic Cholestasis of Pregnancy (ICP) , excluding more controls

O15_ICP_EXMORE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

only females

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O26.6
  • Hospital discharge: ICD-9 6467
  • Cause of death: ICD-10 O26.6
  • Cause of death: ICD-9 6467

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude
!(O15_DELIVERY, O15_DELIVERY_PROXY)

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF3
Parent code in ICD-10
O26
Name in latin
Morbositates hepatis in graviditate, intra labores et/sive in puerperio

Similar endpoints

List of similar endpoints to Intrahepatic Cholestasis of Pregnancy (ICP) , excluding more controls based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 19565 19565 -
Only index persons 19357 19357 -
Unadjusted period prevalence (%)
Whole population 0.56 0.56 -
Only index persons 0.71 0.71 -
Median age at first event (years)
Whole population - 29.97 -
Only index persons - 29.97 -

-FinnGen-

Key figures

All Female Male
Number of individuals 2970 2970 -
Unadjusted period prevalence (%) 1.01 1.01 -
Median age at first event (years) 30.33 30.33 -

-FinRegistry-

Age distribution of first events

02030400k1k2k3k4k5k6k7k8k9kAgeIndividuals

-FinnGen-

Age distribution of first events

01020304050607080900.0k0.2k0.4k0.6k0.8k1.0k1.2k1.4kAgeIndividuals

-FinRegistry-

Year distribution of first events

1970197519801985199019952000200520102015202020220.0k0.5k1.0k1.5k2.0k2.5k3.0kYearIndividuals

-FinnGen-

Year distribution of first events

197019751980198519901995200020052010201520202023050100150200250300350400450500YearIndividuals

-FinRegistry-

Cumulative Incidence Function

01020304050607080901000.00.20.40.60.81.01.21.41.61.82.0AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

01020304050607080901000.00.20.40.60.81.01.21.41.61.82.02.22.42.62.83.0AgeProbability of first incidence (%)

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
2669
Matched controls
26689
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
O26.6
ICD-10 Finland
Liver disorders in pregnancy, childbirth and the puerperium
16384.0
323.0
2068
*
A05AA02
ATC
ursodeoxycholic acid; oral
126.0
323.0
804
91
6467A
ICD-9 Finland
Other complications of pregnancy, not elsewhere classified, Liver disorders in pregnancy[HEPATOSIS GRAVIDARUM]
+∞
323.0
680
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.5
65.8
338
1059
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
2.6
49.6
406
1720
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.5
44.2
403
1802
O80.8
ICD-10 Finland
Other single spontaneous delivery
2.1
31.1
377
1909
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
1.7
26.6
633
4069
O30.0
ICD-10 Finland
Twin pregnancy
3.0
25.1
149
512
MAC10
NOMESCO Finland
Antepartum dilatation of cervical canal
2.4
24.0
206
883
W84
ICPC
Pregnancy high risk
2.1
22.0
276
1406
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
1.5
21.5
1040
7927
63900
ICD-8 Finland
Other toxaemias of pregnancy and the puerperium, Pruritus
16.4
21.4
34
21
MAC01
NOMESCO Finland
Rupture of aminiotic membrane for induction of labor
2.5
18.7
154
643
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
1.6
17.8
575
3958
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
1.6
17.3
585
4068
63998
ICD-8 Finland
Other toxaemias of pregnancy and the puerperium, Alia definitae
22.0
16.8
24
11
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
3.3
16.4
82
251
K76.9
ICD-10 Finland
Liver disease, unspecified
5.2
15.4
47
91
65000
ICD-8 Finland
Delivery without mention of complication, Occipital presentation
0.6
14.8
187
3172
5742A
ICD-9 Finland
Cholelithiasis, Calculus of gallbladder without mention of cholecystitis[CHOLECYSTOLITHIASIS SINE CHOLECYSTITIDE,SINE OBSTR]
4.3
14.8
54
127
L29.9
ICD-10 Finland
Pruritus, unspecified
3.1
14.7
79
257
O60
ICD-10 Finland
Preterm labour and delivery
2.0
14.7
180
911
8811
FHL
Cesarean section
1.8
13.5
236
1356
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
3.5
13.2
61
177
A10BX01
ATC
guar gum; systemic
3.8
12.7
53
142
MAC96
NOMESCO Finland
Other induction or advancement of labour
1.9
12.5
182
983
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
1.5
12.4
564
4146
MAA00
NOMESCO Finland
Amniocentesis
2.0
12.1
152
776
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
1.6
11.8
359
2412
Z35.9
ICD-10 Finland
Supervision of high-risk pregnancy, unspecified
1.8
11.6
211
1232
6510B
ICD-9 Finland
Multiple gestation, Twin pregnancy[GEMINI, SYNNYTYKSEN AIKANA]
4.1
11.2
42
103
XMA22
NOMESCO Finland
General examination of pregnant woman
1.5
11.1
367
2516
S02
ICPC
Pruritus
2.3
10.2
94
421
MAC40
NOMESCO Finland
Pharmacological induction or advancement of labor
2.0
9.8
124
636
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
1.9
9.8
150
828
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
1.3
9.6
979
8179
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.6
9.6
255
1656
6510A
ICD-9 Finland
Multiple gestation, Twin pregnancy[GEMINI, RASKAUDEN AIKANA]
5.0
9.4
29
59
6467X
ICD-9 Finland
Other complications of pregnancy, not elsewhere classified, Liver disorders in pregnancy[HEPATOPATHIA ALIA GRAVIDARUM]
+∞
9.4
9
*
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
1.4
9.1
625
4918
G03DA04
ATC
progesterone; systemic, rectal, vaginal
1.9
8.9
133
729
O36.6
ICD-10 Finland
Maternal care for excessive fetal growth
1.6
8.9
221
1411
L04AX01
ATC
azathioprine; systemic
2.0
8.3
100
506
O13
ICD-10 Finland
Gestational [pregnancy-induced] hypertension
1.5
8.2
268
1828
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.3
8.0
977
8306
K83.9
ICD-10 Finland
Disease of biliary tract, unspecified
8.9
8.0
16
18
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
2.0
7.8
100
518
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.4
7.5
398
2987
O48
ICD-10 Finland
Prolonged pregnancy
0.5
7.5
79
1410
V230A
ICD-9 Finland
Supervision of high-risk pregnancy, Pregnancy with history of infertility
2.6
7.5
52
203
6488A
ICD-9 Finland
Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Abnormal glucose tolerance
2.4
7.5
60
255
6663
FHL
Cholecystectomy and cholangiography
3.6
7.4
31
86
K83.0
ICD-10 Finland
Cholangitis
4.2
7.3
26
63
K50.9
ICD-10 Finland
Crohn disease, unspecified
2.9
7.2
42
148
B18.2
ICD-10 Finland
Chronic viral hepatitis C
3.3
7.2
34
105
O84.2
ICD-10 Finland
Multiple delivery, all by caesarean section
3.1
7.1
37
122
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
3.9
7.1
27
70
O84.0
ICD-10 Finland
Multiple delivery, all spontaneous
2.7
7.0
45
167
O14.9
ICD-10 Finland
Pre-eclampsia, unspecified
2.0
6.8
84
433
O82.0
ICD-10 Finland
Delivery by elective caesarean section
1.5
6.7
254
1792
O26.0
ICD-10 Finland
Excessive weight gain in pregnancy
5.2
6.6
19
37
O61.0
ICD-10 Finland
Failed medical induction of labour
2.1
6.6
69
333
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
1.7
6.5
129
777
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
2.0
6.5
78
398
O98.4
ICD-10 Finland
Viral hepatitis complicating pregnancy, childbirth and the puerperium
5.3
6.5
18
34
1413
FHL
Laparoscopy and other therapeutic procedure
2.1
6.4
66
316
G03GB02
ATC
clomifene; oral
1.8
6.4
101
566
MA2XE
NOMESCO Finland
Other obstetric ultrasound examination
1.4
6.4
383
2933
O26.5
ICD-10 Finland
Maternal hypotension syndrome
14.3
6.4
10
7
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
3.5
6.4
27
77
O99.80
ICD-10 Finland
The fear of childbirth
1.4
6.4
293
2146
K80.1
ICD-10 Finland
Calculus of gallbladder with other cholecystitis
2.5
6.3
45
181
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
4.3
6.2
21
49
H02AB07
ATC
prednisone; oral
1.4
6.2
261
1881
K80.0
ICD-10 Finland
Calculus of gallbladder with acute cholecystitis
2.0
6.1
70
351

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
809
1182
9.03
307.65
6.2
1.5
10.02
3.99
umol/l
20.04
713
833
282
506
6.05
152.00
1.2
1.3
108.47
108.30
u/ml
0.01
55
136
292
545
5.83
151.01
1.2
1.3
—
—
—
0
0
289
552
5.69
145.70
1.2
1.3
14.08
17.13
u/ml
—
5
17
280
521
5.83
145.15
1.2
1.2
200.63
266.59
u/ml
5.08
230
348
340
1101
3.36
84.31
1.2
1.2
—
—
—
0
0
444
2431
1.97
34.44
2.4
2.4
6.01
5.71
umol/l
0.13
396
2063
1428
10880
1.60
33.81
5.0
4.9
9.67
9.33
umol/l
0.67
1343
10245
668
4219
1.75
32.69
1.5
1.6
—
—
—
0
0
1111
8183
1.57
29.03
3.6
2.8
33.97
27.78
u/l
4.55
1065
7851
167
657
2.63
28.59
1.4
1.2
847.14
1185.16
titre
—
7
31
165
660
2.59
27.31
1.5
1.2
74.29
203.06
titre
0.79
14
62
1987
17040
1.50
22.91
7.3
6.3
78.91
70.77
u/l
14.37
1885
16143
2830
26644
2.32
21.61
10.8
7.9
32.16
23.71
u/l
36.75
2787
25999
248
1350
1.91
19.13
1.7
1.8
1.38
1.37
g/l
0.03
229
1267
307
1790
1.80
19.04
2.3
2.5
10.78
10.34
g/l
1.55
282
1661
262
1463
1.87
18.68
2.3
2.1
0.22
0.23
g/l
0.74
245
1383
95
385
2.52
15.39
1.1
1.1
—
—
—
0
0
930
7322
1.39
14.70
5.8
5.5
—
—
—
0
0
94
406
2.36
13.30
1.1
1.1
—
—
—
0
0
1294
10885
1.33
12.92
8.1
7.4
0.00
0.00
e9/l
0.58
1083
9051
568
4252
1.42
11.65
1.5
1.4
718.08
623.66
titre
0.38
125
857
868
6974
1.35
11.49
2.4
2.3
59.55
55.24
u/l
0.49
823
6553
665
5158
1.37
10.97
3.8
2.9
99.46
99.99
%
0.25
640
4971
1310
11249
1.29
10.50
6.2
5.5
7.86
7.74
%
0.85
1260
10614
1302
11179
1.29
10.41
6.0
5.3
2.84
2.81
%
0.20
1239
10434
1255
10727
1.29
10.38
6.1
5.4
0.74
0.68
%
3.91
1202
10020
975
8061
1.31
10.34
4.4
4.0
36.64
37.03
g/l
1.54
917
7572
45
154
2.95
10.19
1.3
1.3
309.09
165.26
titre
0.43
11
38
49
180
2.75
9.77
1.1
1.1
317.48
290.75
mg/l
0.90
42
166
780
6300
1.32
9.66
4.0
4.2
1.03
1.04
inr
0.56
300
2268
2008
18330
1.29
9.52
3.2
2.6
38.90
32.30
u/l
3.97
1917
17653
1348
11719
1.28
9.44
6.0
5.2
30.22
30.04
%
0.31
1290
11019
44
157
2.83
9.27
1.1
1.0
—
—
—
0
0
739
5954
1.32
9.25
1.5
1.4
2.08
2.09
g/l
0.04
483
3908
1369
11969
1.27
8.99
6.0
5.2
0.52
0.51
e9/l
0.41
1240
10664
1328
11569
1.27
8.99
5.9
5.1
55.99
56.32
%
0.59
1274
10904
1369
12016
1.26
8.53
6.0
5.2
0.04
0.04
e9/l
1.45
1239
10676
46
177
2.62
8.43
1.1
1.1
—
—
—
0
0
63
291
2.19
7.76
1.0
1.1
1.41
1.43
g/l
0.13
55
264
1401
12428
1.24
7.62
6.0
5.2
1.94
1.97
e9/l
0.85
1293
11301
401
3039
1.37
7.43
1.9
2.1
14.93
14.81
umol/l
0.13
378
2833
40
154
2.62
7.36
1.4
1.4
—
—
—
0
0
1645
14908
1.23
7.12
3.1
3.0
56.81
64.46
ug/l
3.93
1573
14230
271
1936
1.44
7.07
2.5
2.2
35.70
35.62
u/l
0.01
244
1663
1403
12523
1.23
6.96
6.2
5.3
0.18
0.18
e9/l
0.07
1297
11349
2397
22687
1.29
6.92
12.6
11.1
13.41
13.42
%
0.06
2372
22297
319
2358
1.40
6.87
1.9
2.1
24.39
24.43
%
0.02
275
2029
672
5539
1.28
6.80
2.6
2.5
0.16
0.25
e6/l
2.41
502
4087
677
5604
1.27
6.59
2.6
2.5
—
—
—
0
0
674
5584
1.27
6.50
2.2
2.0
2.50
2.61
mg/l
0.74
595
4869
357
2713
1.36
6.48
1.9
2.0
2.52
2.51
g/l
0.11
329
2513
1973
18327
1.23
6.33
4.1
3.6
9.60
9.00
mm/h
1.79
1879
17409
735
6173
1.25
6.29
2.7
2.6
35.24
80.11
e6/l
1.10
545
4623
1145
10097
1.22
6.16
2.4
2.2
75.21
74.40
nmol/l
0.48
1084
9558
99
583
1.72
6.05
2.2
2.0
1.14
1.26
g/l
0.62
83
511
33
130
2.56
5.86
3.0
3.0
8.75
7.30
mg/l
0.53
26
96
76
420
1.83
5.77
4.2
3.4
1035.77
435.64
u/ml
0.33
67
359
1503
13671
1.20
5.69
7.8
7.4
3.82
3.91
e9/l
1.00
1352
12110
110
684
1.63
5.51
2.2
1.5
7.54
5.95
u/ml
—
5
16
331
2552
1.33
5.46
1.2
1.2
—
—
—
0
0
1968
18393
1.21
5.43
4.2
3.9
—
—
—
0
0
479
3892
1.28
5.35
2.3
2.3
537.88
530.62
mosm/kgh2o
0.27
410
3316
73
416
1.77
5.06
1.7
1.6
0.44
0.65
g/l
2.23
60
314
838
7304
1.21
4.83
1.3
1.3
1.02
1.51
u/ml
1.54
253
2277
521
4329
1.25
4.78
2.3
2.2
9.66
8.48
e6/l
0.27
450
3741
641
5469
1.22
4.57
1.3
1.3
10.17
8.63
u/ml
0.29
259
2429
322
2538
1.30
4.55
3.4
3.2
—
—
—
0
0
1042
9333
1.18
4.32
2.1
1.8
—
—
—
0
0
2537
24511
1.24
4.12
5.1
5.0
1.64
1.87
mu/l
1.28
2420
23490
889
7901
1.18
3.98
3.1
3.0
72.37
64.56
e6/l
0.15
602
5129
44
233
1.90
3.92
1.1
1.2
—
—
—
0
0
626
5406
1.20
3.89
2.1
2.0
683.75
1799.52
umol/l
1.64
561
4881
2289
21927
1.19
3.88
4.6
4.4
14.25
14.21
pmol/l
0.36
2156
20907
475
3995
1.22
3.87
3.2
2.4
94.43
94.41
ug/g
0.00
383
3155
371
3039
1.25
3.85
1.2
1.2
—
—
—
0
0
327
2640
1.27
3.84
1.4
1.4
—
—
—
0
0
653
5677
1.19
3.76
1.3
1.3
24.17
25.18
iu/ml
0.07
199
1838
599
5174
1.20
3.70
3.2
3.3
7.39
7.40
ph
2.01
135
1060
995
8968
1.16
3.68
4.9
5.0
1.22
1.22
mmol/l
0.26
847
7589
311
2513
1.27
3.64
2.2
1.9
29.02
28.80
s
0.29
295
2415
878
7845
1.17
3.63
4.6
4.4
1.22
1.22
mmol/l
0.53
834
7214
51
291
1.77
3.62
4.0
3.2
—
—
—
0
0
327
2666
1.25
3.55
1.8
1.8
—
—
—
0
0
2516
24368
1.21
3.50
9.1
8.4
3.88
3.89
mmol/l
0.93
2460
23709
301
2434
1.26
3.50
1.5
1.3
—
—
—
0
0
37
196
1.90
3.34
2.2
2.0
—
—
—
0
0
2506
24287
1.20
3.33
9.0
8.4
139.63
139.60
mmol/l
0.36
2448
23709
809
7228
1.16
3.30
1.7
1.7
100.92
100.44
pmol/l
0.10
426
4057
97
679
1.44
2.98
1.2
1.2
—
—
—
0
0
351
2941
1.22
2.98
2.2
2.3
5.39
4.91
e6/l
0.18
178
1537
568
4974
1.18
2.96
3.6
3.1
7.59
7.68
mmol/l
0.17
499
4374
879
7963
1.15
2.91
2.9
2.7
—
—
—
0
0
372
3143
1.21
2.90
2.2
2.2
2.32
1.02
e6/l
0.49
198
1731
614
5421
1.17
2.89
1.5
1.6
1.23
1.33
mmol/l
1.76
544
4764
675
6011
1.16
2.83
1.9
1.7
0.94
0.82
mg/l
0.70
500
4444
54
337
1.61
2.83
3.4
2.3
2.15
2.06
mmol/l
0.10
30
199
2131
20466
1.15
2.83
4.0
3.8
36.97
37.02
mmol/mol
0.10
2028
19526
438
3767
1.19
2.82
1.4
1.4
20.96
21.13
nmol/l
0.10
393
3391
279
2297
1.24
2.81
2.8
3.5
4.58
4.57
pmol/l
0.01
258
2086
14
53
2.65
2.79
1.3
3.1
13180.67
63.34
mg/l
—
9
38
599
5292
1.17
2.79
1.9
1.9
113.56
136.10
u/l
0.83
578
5056
135
1019
1.34
2.69
6.3
6.7
6.77
6.61
mmol/l
0.13
128
988
223
1802
1.26
2.66
4.2
3.8
1.28
1.00
%
0.36
43
369
476
4148
1.18
2.63
4.1
3.8
11.14
11.04
mg/mmol
0.02
303
2629
110
813
1.37
2.53
1.2
1.3
6.92
7.41
u/ml
0.04
14
140
174
1374
1.28
2.52
1.2
1.3
0.27
0.93
u/ml
1.70
12
109
53
340
1.57
2.51
1.4
1.3
—
—
—
0
0
1096
10154
1.13
2.49
2.0
2.0
—
—
—
0
0
51
325
1.58
2.49
2.8
2.3
—
—
—
0
0
264
2192
1.22
2.48
1.3
1.3
212.84
147.63
u/ml
0.34
254
2051
144
1112
1.31
2.48
1.7
1.7
—
—
—
0
0
38
225
1.70
2.47
1.0
1.1
8.69
9.97
iu/ml
—
10
59
457
3992
1.17
2.46
3.4
3.2
512.13
538.25
mg/l
0.03
288
2479
633
5667
1.15
2.45
5.8
5.6
—
—
—
0
0
222
1812
1.24
2.45
1.2
1.2
—
—
—
0
0
108
801
1.36
2.44
1.3
1.3
7.40
6.22
u/ml
—
9
79
103
759
1.37
2.43
1.2
1.3
64.44
39.39
u/ml
—
7
72
213
1735
1.25
2.40
4.3
3.9
0.28
0.27
%
0.02
40
343
69
477
1.46
2.33
1.0
1.0
—
—
—
0
0
308
2614
1.20
2.32
3.0
3.1
0.83
0.83
mmol/l
0.41
293
2474
183
1473
1.26
2.30
3.1
3.1
1.22
1.23
mmol/l
1.77
167
1282
203
1655
1.24
2.28
3.8
3.7
0.76
0.63
%
0.24
34
279
33
193
1.72
2.26
1.8
2.5
61.49
62.31
%
0.07
33
193
71
499
1.43
2.22
3.7
3.7
57.21
57.16
%
0.01
71
499
204
1670
1.24
2.21
4.4
3.9
0.11
0.30
%
0.29
35
291
285
2417
1.20
2.18
1.8
2.1
371.83
370.95
nmol/l
0.03
265
2261
332
2855
1.18
2.17
2.3
2.3
311.59
378.69
ng/l
0.42
262
2284
77
553
1.40
2.15
1.2
1.1
12.11
11.61
au/ml
0.03
12
36
783
7166
1.13
2.14
2.3
2.2
—
—
—
0
0
718
6537
1.13
2.14
2.6
2.8
2.34
2.34
mmol/l
0.11
655
5984
1358
12825
1.11
2.09
4.0
3.6
6.10
6.14
mmol/l
0.31
1219
11237
1867
17926
1.11
2.09
4.3
3.8
838.71
1363.88
e6/l
0.26
17
181
57
814
0.69
2.02
6.7
6.4
—
—
—
0
0
2793
27546
1.23
2.00
10.1
9.0
—
—
—
0
0
1404
13303
1.11
2.00
3.2
3.1
0.00
0.00
estimate
0.69
356
2774
39
248
1.58
1.98
3.6
2.9
28.93
32.57
umol/l
0.86
30
217
1549
14755
1.10
1.97
2.6
2.5
—
—
—
0
0
78
1049
0.74
1.94
1.3
1.3
2.93
4.06
ug/l
1.54
73
973
11
45
2.45
1.93
1.2
1.1
—
—
u/ml
—
0
0
117
915
1.29
1.90
1.3
1.3
85.86
28.89
u/ml
—
5
71
463
4135
1.14
1.86
1.6
1.5
19324101.70
47560081.51
pmol/l
0.71
414
3688
46
310
1.49
1.83
1.4
1.3
—
—
—
0
0
2367
23088
1.12
1.82
3.3
3.2
5.53
5.53
mmol/l
0.00
2227
21918
79
588
1.35
1.82
2.6
2.4
—
—
—
0
0
706
6479
1.12
1.82
4.3
3.7
—
—
—
0
0
27
161
1.68
1.78
1.1
1.3
—
—
—
0
0
58
412
1.42
1.77
3.3
2.5
7.42
7.43
ph
1.13
51
336
91
1178
0.77
1.76
1.3
1.2
11.44
11.84
u/l
0.11
78
1016
23
132
1.75
1.73
1.3
1.3
—
—
—
0
0
5
13
3.85
1.71
2.4
2.0
—
—
—
0
0
74
552
1.35
1.70
2.5
2.8
—
—
—
0
0
2634
25892
1.15
1.70
10.5
9.5
16.15
17.67
mg/l
2.03
2054
20126
1405
13391
1.09
1.67
4.4
4.3
0.00
0.00
estimate
0.80
365
2883
1414
13482
1.09
1.66
3.2
3.2
0.00
0.00
estimate
1.32
367
2835
33
214
1.55
1.59
1.1
1.3
—
—
—
0
0
65
481
1.36
1.59
1.3
1.4
—
—
—
0
0
381
3399
1.14
1.58
2.6
2.2
6722.92
6893.16
u/l
0.04
168
1543
120
973
1.24
1.51
1.7
2.2
3.28
4.34
iu/l
1.59
44
415
160
1337
1.21
1.51
2.2
2.5
1.61
1.68
%
0.40
142
1208
132
1600
0.82
1.49
3.1
3.1
—
—
—
0
0
222
1914
1.17
1.48
4.2
4.6
1.05
1.04
mmol/l
0.42
212
1800
2538
24932
1.12
1.46
11.5
9.9
39.46
39.51
%
0.14
2128
20808
1138
10796
1.09
1.45
2.3
2.1
—
—
—
0
0
37
253
1.47
1.43
2.5
2.8
9.49
112.09
ug/min
3.20
28
170
10
46
2.18
1.40
2.8
2.9
—
—
—
0
0
449
4089
1.12
1.34
3.4
3.3
—
—
—
0
0
573
5290
1.10
1.32
2.3
2.2
—
—
—
0
0
108
882
1.23
1.31
2.2
2.0
0.22
0.23
g/l
0.16
103
833
35
242
1.45
1.30
1.3
1.1
—
—
—
0
0
19
114
1.67
1.28
1.9
1.6
1.79
1.95
umol/l
0.53
19
108
15
84
1.79
1.27
1.0
1.1
—
—
—
0
0
65
501
1.30
1.26
1.2
1.2
—
—
—
0
0
22
138
1.60
1.26
1.6
1.7
2.33
2.64
mg/l
0.43
22
132
19
115
1.66
1.24
1.1
1.1
—
—
—
0
0
101
825
1.23
1.23
1.8
2.2
55.45
68.92
ng/l
0.59
86
731
35
491
0.71
1.22
1.5
1.4
32.56
30.58
nmol/l
0.15
28
442
37
262
1.42
1.22
1.1
1.1
—
—
—
0
0
12
63
1.91
1.22
1.8
2.6
—
—
—
0
0
278
2477
1.13
1.21
1.3
1.3
—
—
—
0
0
35
246
1.43
1.21
1.6
2.6
—
—
—
0
0
120
1001
1.21
1.20
2.4
2.2
67.18
67.54
g/l
0.26
112
937
15
86
1.75
1.19
1.1
1.1
—
—
—
0
0
336
3037
1.12
1.17
1.2
1.2
166.58
158.80
iu/ml
0.13
135
1278
70
553
1.27
1.15
3.4
3.3
23.80
24.12
mmol/l
0.37
59
490
15
87
1.73
1.15
1.1
1.2
—
—
—
0
0
16
95
1.69
1.13
1.9
2.4
9.19
11.07
%
1.25
16
95
69
546
1.27
1.13
1.4
1.3
332.06
331.38
ug/g
0.01
32
257
2456
24163
1.09
1.11
3.4
3.3
4.79
4.88
mmol/l
5.35
2362
23214
118
992
1.20
1.11
2.2
2.5
—
—
—
0
0
354
3223
1.11
1.09
1.2
1.2
—
—
—
0
0
696
6541
1.08
1.09
2.3
2.3
21.44
22.12
ng/l
0.04
235
2417
77
621
1.25
1.08
1.8
1.8
—
—
—
0
0
122
1032
1.19
1.08
1.1
1.1
8.55
5.30
u/ml
0.17
17
171
81
659
1.24
1.06
13.2
8.8
—
—
—
0
0
43
567
0.75
1.05
1.9
2.4
—
—
—
0
0
13
75
1.74
1.02
33.8
25.0
118.08
116.94
ug/l
0.02
13
63
103
863
1.20
1.02
2.0
2.6
4.83
4.66
kpa
0.26
98
832
15
239
0.63
1.02
1.5
1.1
—
—
—
0
0
41
307
1.34
1.02
1.1
1.5
—
2933.33
—
0
6
292
2646
1.11
1.00
1.7
1.6
1151.06
1208.31
nmol/l
0.56
236
2171
7
134
0.52
0.98
1.7
1.1
—
—
—
0
0
32
232
1.38
0.97
2.3
2.6
1.41
1.48
%
0.06
27
180
12
199
0.60
0.96
1.2
1.5
—
—
—
0
0
12
199
0.60
0.96
1.2
1.5
—
—
—
0
0
12
199
0.60
0.96
1.2
1.5
—
—
—
0
0
12
199
0.60
0.96
1.2
1.5
—
—
—
0
0
36
267
1.35
0.96
1.4
1.2
—
—
nmol/l
—
0
0
89
741
1.21
0.96
1.2
1.1
—
—
—
0
0
767
7273
1.07
0.95
3.4
3.4
0.01
0.00
estimate
0.53
362
2846
38
285
1.34
0.94
1.5
1.6
—
—
—
0
0
279
2533
1.11
0.93
1.3
1.4
—
—
—
0
0
16
245
0.65
0.93
1.0
1.1
—
—
—
0
0
88
735
1.20
0.92
1.2
1.3
—
—
—
0
0
73
599
1.22
0.91
2.1
2.1
10.40
9.87
mg/l
0.22
68
568
2914
29002
1.25
0.91
16.2
14.2
266.92
267.53
e9/l
0.22
2874
28592
62
502
1.24
0.88
1.3
1.2
2.13
4.84
u/ml
2.55
24
189
2466
24324
1.08
0.88
3.5
3.5
2.89
2.95
mmol/l
3.38
2354
23199
270
2459
1.11
0.87
1.4
1.3
—
—
—
0
0
19
128
1.49
0.85
1.2
1.1
—
—
—
0
0
39
300
1.30
0.84
1.8
2.0
17.54
17.01
%
0.33
16
148
130
1134
1.15
0.84
5.3
2.8
—
—
—
0
0
145
1277
1.14
0.82
3.0
2.1
—
—
—
0
0
35
267
1.31
0.81
1.3
1.2
—
—
—
0
0
83
701
1.19
0.80
4.4
2.7
—
—
—
0
0
0
24
0.00
0.79
0.0
4.0
—
2087.71
—
0
24
8
48
1.67
0.78
1.6
1.6
—
—
—
0
0
8
48
1.67
0.78
3.6
4.9
—
—
—
0
0
44
349
1.26
0.77
1.9
1.6
14157.81
7179.80
e6/l
0.34
31
257
2341
23085
1.07
0.75
3.1
3.0
1.09
1.17
mmol/l
8.31
2255
22148
14
91
1.54
0.75
1.2
1.2
—
—
—
0
0
110
958
1.15
0.75
2.2
1.7
21.19
20.56
s
0.42
96
762
85
726
1.18
0.74
1.1
1.1
1.83
1.30
u/ml
0.20
20
184
76
644
1.18
0.73
1.1
1.1
—
—
—
0
0
228
2082
1.10
0.72
2.3
2.3
19.59
23.09
au/ml
0.27
11
171
10
159
0.63
0.72
1.8
1.5
20.20
25.15
umol/l
—
10
152
76
645
1.18
0.72
1.1
1.1
—
—
—
0
0
2437
24074
1.07
0.71
3.4
3.3
1.55
1.55
mmol/l
0.15
2345
23089
497
4693
1.07
0.71
2.3
2.4
—
—
—
0
0
2914
29025
1.21
0.71
16.1
14.1
89.80
90.10
fl
3.68
2899
28856
2914
29025
1.21
0.71
16.1
14.1
29.85
30.02
pg
6.58
2899
28857
26
194
1.34
0.71
1.7
1.6
48.59
45.77
%
0.12
17
109
9
57
1.58
0.71
1.1
1.5
—
—
—
0
0
31
238
1.31
0.70
1.8
1.4
—
—
—
0
0
167
1505
1.12
0.69
2.8
2.1
—
—
—
0
0
2914
29028
1.20
0.68
16.2
14.2
6.65
6.75
e9/l
1.50
2877
28573
5
27
1.85
0.68
1.2
1.2
—
—
—
0
0
9
59
1.53
0.68
1.1
1.2
—
5.71
—
0
11
2914
29029
1.20
0.68
16.2
14.2
4.45
4.45
e12/l
0.01
2878
28604
207
1890
1.10
0.67
2.0
1.9
3.71
4.07
e9/l
2.00
177
1637
17
119
1.43
0.66
1.1
1.2
—
—
—
0
0
31
241
1.29
0.65
1.0
1.0
—
—
—
0
0
870
8380
1.05
0.65
2.1
1.8
—
—
—
0
0
7
44
1.59
0.65
2.1
2.8
57.79
48.13
%
—
7
44
21
154
1.37
0.65
1.1
1.1
12.88
8.03
u/ml
—
5
34
99
868
1.15
0.64
1.1
1.1
2.19
1.54
u/ml
0.32
35
312
171
1551
1.11
0.64
8.6
8.2
1.07
1.05
inr
0.19
32
306
5
29
1.73
0.64
1.2
1.1
—
—
—
0
0
8
128
0.62
0.64
1.8
1.5
—
—
—
0
0
178
1620
1.11
0.63
1.4
1.3
—
—
—
0
0
47
387
1.22
0.63
3.0
1.9
111.22
234.62
ug/l
1.50
38
332
72
618
1.17
0.62
1.1
1.1
1.05
4.90
u/ml
5.73
30
241
5
30
1.67
0.61
1.0
1.0
—
—
—
0
0
5
30
1.67
0.61
1.0
1.4
—
—
—
0
0
36
289
1.25
0.61
1.1
1.4
—
—
—
0
0
43
521
0.82
0.60
2.7
4.6
—
—
—
0
0
69
801
0.86
0.60
4.8
7.3
24.30
24.18
mmol/l
0.13
62
749
0
21
0.00
0.60
0.0
1.1
—
24.86
—
0
7
127
1139
1.12
0.59
2.7
3.0
72.66
71.35
ng/l
0.07
118
1025
80
917
0.87
0.59
1.6
1.8
11.39
4.60
ug/l
0.88
73
810
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
833
8040
1.05
0.58
1.8
1.7
—
—
—
0
0
85
744
1.15
0.58
2.5
2.0
—
—
—
0
0
2914
29041
1.18
0.58
16.3
14.2
132.35
133.08
g/l
3.54
2899
28861
141
1275
1.11
0.58
1.6
1.7
—
—
—
0
0
59
502
1.18
0.57
3.6
5.2
1.71
1.81
%
0.15
54
465
15
207
0.72
0.56
1.5
2.1
13.14
12.77
%
—
7
118
143
1296
1.11
0.56
1.1
1.1
—
—
—
0
0
353
3330
1.07
0.55
1.3
1.3
28.24
27.68
iu/l
0.11
316
2935
11
159
0.69
0.54
1.8
2.8
939.00
818.49
e6/l
—
6
70
20
151
1.33
0.54
2.1
1.5
44.28
45.45
%
0.04
15
81
58
497
1.17
0.53
3.6
5.4
0.91
0.93
%
0.18
53
461
6
40
1.50
0.51
1.2
1.2
—
—
—
0
0
6
40
1.50
0.51
1.2
1.2
—
—
—
0
0
6
40
1.50
0.51
1.2
1.2
—
—
—
0
0
34
278
1.23
0.51
1.4
1.4
—
—
—
0
0
60
519
1.16
0.50
1.2
1.3
—
—
—
0
0
6
41
1.46
0.50
1.3
1.0
—
—
—
0
0
35
288
1.22
0.50
1.6
1.5
—
—
—
0
0
75
660
1.14
0.50
2.9
3.1
0.20
0.34
g/l
2.05
32
259
96
861
1.12
0.48
2.1
2.2
—
—
—
0
0
30
244
1.23
0.48
4.2
4.0
32.28
49.47
mg/l
0.46
24
203
118
1071
1.11
0.48
2.7
3.1
1.33
1.75
mmol/l
0.56
90
862
20
256
0.78
0.48
1.5
2.5
1.52
1.40
e9/l
0.15
11
154
29
236
1.23
0.46
1.1
1.2
0.05
0.60
u/ml
—
8
82
101
911
1.11
0.46
2.2
2.6
66.80
72.45
e9/l
0.99
67
672
35
291
1.21
0.46
1.1
1.4
0.35
0.37
g/l
0.15
23
201
35
291
1.21
0.46
1.1
1.4
6.41
6.33
g/l
0.05
21
204
35
291
1.21
0.46
1.1
1.4
3.42
3.00
g/l
0.71
23
202
563
5848
0.95
0.46
3.1
3.2
—
—
—
0
0
51
440
1.16
0.45
2.4
2.3
—
—
—
0
0
84
751
1.12
0.45
1.7
1.5
6.29
6.55
mmol/l
0.58
55
527
35
292
1.20
0.45
1.2
1.3
—
—
—
0
0
104
942
1.11
0.45
1.1
1.2
—
—
—
0
0
196
1828
1.08
0.45
1.4
1.3
219.59
232.41
miu/ml
0.20
98
938
7
51
1.37
0.44
4.1
3.6
—
—
—
0
0
45
386
1.17
0.43
1.5
2.1
133.72
130.70
g/l
0.61
36
297
112
1022
1.10
0.42
12.0
6.8
—
—
—
0
0
74
660
1.12
0.42
1.1
1.1
1.40
5.21
u/ml
1.84
27
249
69
614
1.13
0.41
1.1
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
5.4
—
—
—
0
0
8
59
1.36
0.41
2.4
1.5
—
—
—
0
0
8
60
1.33
0.40
2.8
2.6
509.25
500.02
min
—
8
49
8
60
1.33
0.40
1.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
3.9
—
—
—
0
0
104
950
1.10
0.39
1.8
1.6
7.31
7.50
mmol/l
0.37
67
568
234
2209
1.06
0.39
2.9
3.1
32.92
32.77
%
0.08
178
1750
59
522
1.13
0.39
1.2
1.1
—
—
—
0
0
427
4102
1.05
0.39
1.5
1.5
—
—
—
0
0
60
532
1.13
0.38
1.1
1.1
0.05
0.42
u/ml
0.64
13
107
9
67
1.34
0.38
1.2
1.4
—
—
—
0
0
86
781
1.10
0.37
1.1
1.1
3.37
5.71
u/ml
1.02
39
399
36
419
0.86
0.37
2.8
2.0
1.93
1.57
ug/l
0.11
29
383
5
37
1.35
0.37
1.0
1.0
—
—
—
0
0
29
244
1.19
0.36
4.3
3.9
20.40
26.67
mg/l
0.67
23
204
147
1371
1.08
0.36
4.6
3.5
35.47
38.73
ug/l
0.03
107
964
40
347
1.15
0.35
2.2
2.2
—
—
—
0
0
54
479
1.13
0.35
1.6
1.5
11.54
10.14
mmol/l
—
7
31
6
42
1.43
0.35
1.5
2.7
—
—
—
0
0
1128
11065
1.03
0.35
1.9
1.9
—
—
—
0
0
62
556
1.12
0.34
1.2
1.3
—
—
—
0
0
10
73
1.37
0.34
1.0
1.2
—
—
—
0
0
178
1676
1.07
0.34
2.8
2.0
—
—
—
0
0
2326
23439
0.96
0.34
13.2
11.6
331.39
332.20
g/l
4.64
2311
23276
25
209
1.20
0.34
1.1
1.2
—
—
—
0
0
186
1755
1.06
0.34
2.4
2.5
—
—
—
0
0
73
803
0.91
0.33
1.7
1.8
—
—
—
0
0
476
4920
0.96
0.33
1.4
1.5
—
—
—
0
0
177
1670
1.06
0.32
2.7
1.9
—
—
—
0
0
6
47
1.28
0.32
2.3
2.0
—
—
—
0
0
17
137
1.24
0.32
1.1
1.1
—
—
—
0
0
80
732
1.10
0.32
1.1
1.1
0.87
1.35
u/ml
0.38
29
278
337
3240
1.05
0.31
1.5
1.5
—
—
—
0
0
19
156
1.22
0.31
2.1
2.8
—
—
—
0
0
7
96
0.73
0.30
1.6
1.5
—
—
—
0
0
39
343
1.14
0.30
1.5
2.8
23.98
24.23
mmol/l
0.18
32
304
7
54
1.30
0.30
1.0
1.1
—
—
—
0
0
7
54
1.30
0.30
1.0
1.0
—
—
—
0
0
285
2733
1.05
0.30
1.5
1.6
—
—
—
0
0
64
582
1.10
0.29
1.1
1.0
1.75
3.99
u/ml
1.96
33
312
22
185
1.19
0.29
4.5
4.3
—
—
—
0
0
30
261
1.15
0.27
1.1
1.2
—
—
—
0
0
175
1663
1.06
0.27
2.8
2.0
—
—
—
0
0
308
2969
1.04
0.27
2.0
2.3
2.41
2.41
mmol/l
0.54
268
2573
46
510
0.90
0.26
1.9
2.3
24.39
24.59
mmol/l
0.29
40
474
10
77
1.30
0.26
1.1
1.1
64.74
73.45
ug/l
—
10
70
20
169
1.18
0.25
2.2
2.3
—
—
—
0
0
319
3084
1.04
0.25
2.6
2.5
343.98
275.07
ng/l
0.15
138
1400
24
207
1.16
0.25
1.8
1.4
—
—
—
0
0
17
142
1.20
0.24
1.2
1.1
—
—
—
0
0
9
77
1.17
0.24
3.1
1.6
—
—
—
0
0
6
82
0.73
0.24
1.2
1.2
—
—
—
0
0
207
1986
1.05
0.23
1.7
1.5
417.30
282.37
mu/l
0.43
181
1756
71
765
0.93
0.23
3.8
5.4
—
—
—
0
0
41
370
1.11
0.23
1.2
1.5
—
2.71
—
0
7
5
38
1.32
0.23
1.8
2.3
4.08
2.97
ug/l
—
5
33
10
79
1.27
0.22
1.3
1.2
—
—
—
0
0
5
41
1.22
0.22
3.6
1.1
42.50
37.59
%
—
5
35
20
231
0.86
0.22
1.1
1.1
1770.25
1485.30
miu/ml
0.63
20
231
30
267
1.12
0.21
1.1
1.1
1.08
1.04
ratio
0.50
13
96
0
11
0.00
0.21
0.0
5.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.8
—
35.50
—
0
10
148
1549
0.95
0.21
1.2
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
96.53
—
0
6
5
43
1.16
0.21
1.4
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
2.0
—
—
—
0
0
564
5756
0.98
0.20
3.4
3.3
1.02
1.02
kg/l
0.26
91
919
0
14
0.00
0.20
0.0
1.0
—
0.04
—
0
6
184
1770
1.04
0.20
1.3
1.2
—
—
—
0
0
16
136
1.18
0.20
1.2
1.4
—
—
—
0
0
15
176
0.85
0.20
1.2
1.6
0.80
1.31
promille
—
10
126
25
222
1.13
0.19
1.4
2.5
—
—
—
0
0
66
618
1.07
0.18
1.1
1.2
3.59
3.54
mmol/l
0.17
61
581
12
142
0.84
0.17
1.2
1.3
—
—
—
0
0
13
110
1.18
0.17
1.3
1.6
121.31
122.31
nmol/l
0.03
13
110
273
2803
0.97
0.16
1.7
1.7
—
—
—
0
0
12
101
1.19
0.16
1.2
1.1
—
—
—
0
0
8
70
1.14
0.16
2.6
1.5
—
—
—
0
0
11
92
1.20
0.16
1.5
1.3
5.67
6.45
mmol/l
1.08
11
86
8
72
1.11
0.16
1.0
1.0
—
—
—
0
0
8
72
1.11
0.16
1.0
1.0
—
—
—
0
0
8
72
1.11
0.16
1.0
1.0
—
—
—
0
0
13
151
0.86
0.15
1.3
2.4
—
—
—
0
0
17
149
1.14
0.15
1.6
2.6
—
—
—
0
0
32
293
1.09
0.15
3.3
1.6
—
—
—
0
0
48
449
1.07
0.15
1.4
1.5
—
—
—
0
0
9
82
1.10
0.15
2.3
1.4
38.14
36.17
g/l
—
9
77
19
169
1.13
0.14
2.3
1.9
—
—
—
0
0
621
6127
1.02
0.13
1.9
1.8
—
—
—
0
0
17
190
0.89
0.13
5.5
6.7
—
—
—
0
0
44
468
0.94
0.12
3.5
3.3
30.04
21.36
mg/l
0.65
28
285
45
423
1.06
0.12
1.4
1.3
1.22
1.31
nmol/l
0.20
32
361
14
123
1.14
0.12
1.1
1.1
—
—
—
0
0
17
152
1.12
0.12
1.3
2.4
—
—
—
0
0
167
1714
0.97
0.11
1.3
1.3
—
—
—
0
0
171
1667
1.03
0.11
1.8
1.9
—
—
—
0
0
37
347
1.07
0.11
3.2
4.2
37.59
93.59
u/ml
—
8
114
64
612
1.05
0.11
1.2
1.4
1158.14
2277.39
e6/l
0.33
50
508
114
1175
0.97
0.10
11.7
7.2
122.16
121.92
g/l
0.05
108
1127
1349
13567
0.99
0.10
4.4
4.0
—
—
—
0
0
79
762
1.04
0.09
1.2
1.1
—
—
—
0
0
99
1021
0.97
0.09
1.4
1.4
0.38
0.53
nmol/l
1.64
81
831
36
340
1.06
0.09
2.3
2.5
0.81
0.83
nmol/l
0.05
28
298
5
48
1.04
0.09
1.0
1.7
—
—
—
0
0
135
1384
0.97
0.09
10.4
6.7
0.28
0.74
mmol/l
0.76
104
1035
6
54
1.11
0.09
2.2
1.9
—
—
—
0
0
49
512
0.96
0.08
3.9
5.4
1.04
1.14
mmol/l
0.63
43
447
5
60
0.83
0.08
1.0
1.1
—
—
—
0
0
5
63
0.79
0.08
1.0
1.0
—
—
—
0
0
5
65
0.77
0.08
1.4
2.8
17.44
15.30
umol/l
—
5
65
58
602
0.96
0.08
1.1
1.1
—
—
—
0
0
201
1976
1.02
0.07
2.7
2.3
24.31
30.77
u/ml
0.82
196
1913
6
72
0.83
0.07
1.0
1.3
—
—
—
0
0
7
84
0.83
0.07
1.0
2.3
—
—
—
0
0
11
122
0.90
0.07
1.2
1.8
106.73
105.97
mmol/l
0.66
11
122
11
122
0.90
0.07
1.2
1.8
4.00
3.93
mmol/l
0.30
11
122
35
334
1.05
0.06
1.6
1.3
—
—
—
0
0
8
94
0.85
0.06
2.3
2.0
—
—
—
0
0
16
173
0.92
0.06
1.4
1.6
—
—
—
0
0
35
335
1.05
0.06
2.3
2.8
—
—
—
0
0
63
612
1.03
0.06
1.2
1.3
3.14
22.61
e6/l
3.61
44
478
1021
10255
0.99
0.05
2.2
1.9
—
—
—
0
0
20
188
1.06
0.05
1.1
1.2
—
—
—
0
0
12
110
1.09
0.05
1.3
1.9
—
—
—
0
0
31
298
1.04
0.04
2.3
1.9
—
—
—
0
0
15
160
0.94
0.04
1.3
1.4
1456.67
405.97
mu/l
0.40
15
153
11
119
0.92
0.04
1.2
1.8
—
—
—
0
0
13
121
1.07
0.03
4.3
2.0
—
—
—
0
0
165
1668
0.99
0.03
2.6
3.1
—
—
—
0
0
104
1027
1.01
0.03
1.4
1.4
25.84
23.76
u/l
0.26
84
854
83
818
1.02
0.02
1.7
2.5
7.41
7.42
ph
0.19
14
120
123
1217
1.01
0.02
10.9
7.0
96.23
96.58
%
0.18
117
1172
27
261
1.03
0.02
1.0
1.1
—
—
—
0
0
164
1626
1.01
0.02
1.1
1.1
—
—
—
0
0
13
138
0.94
0.02
1.0
1.0
—
—
—
0
0
71
699
1.02
0.02
1.1
1.3
419.97
453.06
mg/l
0.28
65
668
15
142
1.06
0.02
1.5
2.1
30.20
32.18
pg
0.59
15
142
417
4187
1.00
0.02
1.3
1.3
—
—
—
0
0
137
1382
0.99
0.02
10.3
6.7
5.00
4.98
kpa
0.13
132
1329
137
1382
0.99
0.02
10.3
6.7
14.35
13.96
kpa
0.29
132
1327
139
1379
1.01
0.02
1.3
1.3
—
—
—
0
0
260
2612
0.99
0.01
1.6
1.5
—
—
—
0
0
15
157
0.96
0.01
1.7
1.8
1.17
2.27
u/field
—
6
80
256
2569
1.00
0.01
1.5
1.5
—
—
—
0
0
32
314
1.02
0.00
1.0
1.1
167.83
197.69
mg/l
1.41
26
278
258
2574
1.00
0.00
1.5
1.5
—
—
—
0
0
11
115
0.96
0.00
1.4
2.0
—
—
—
0
0
15
155
0.97
0.00
1.1
3.6
—
—
—
0
0
32
325
0.98
0.00
1.1
1.2
46.60
34.88
mg/l
0.33
23
271
23
234
0.98
0.00
1.1
1.1
—
—
—
0
0
11
112
0.98
0.00
1.1
1.5
11.56
13.63
pmol/l
1.06
11
94
72
724
0.99
0.00
1.5
1.5
—
—
—
0
0
118
1178
1.00
0.00
1.6
1.7
—
—
—
0
0
10
97
1.03
0.00
1.8
3.3
—
—
—
0
0
10
103
0.97
0.00
1.0
1.1
—
—
—
0
0
98
977
1.00
0.00
1.9
2.3
0.35
0.20
e6/l
0.53
92
921
17
167
1.02
0.00
1.3
1.4
74.14
72.96
%
0.14
17
160
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
561.47
—
0
9
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
8
86
0.93
0.00
8.1
13.7
1197.88
1274.30
nmol/l
—
8
80
0
5
0.00
0.00
0.0
1.0
—
11.08
—
0
5
83
830
1.00
0.00
1.7
2.6
4.99
5.08
kpa
0.54
73
775
0
5
0.00
0.00
0.0
2.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
10
100
1.00
0.00
4.1
2.9
—
—
—
0
0
5
52
0.96
0.00
1.2
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
5
56
0.89
0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
9
94
0.96
0.00
3.6
2.4
1.69
1.61
nmol/l
—
9
83
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
79.60
—
0
5
6
59
1.02
0.00
1.2
2.3
—
—
—
0
0
5
49
1.02
0.00
1.2
1.3
—
—
—
0
0
6
68
0.88
0.00
2.7
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
2.3
—
—
—
0
0
12
120
1.00
0.00
1.0
1.1
0.11
3.08
u/ml
—
7
60
5
52
0.96
0.00
1.6
1.5
12.54
68.60
u/l
—
5
46

Mortality – FinRegistry

Association

Association between endpoint O15_ICP_EXMORE and mortality.

Females

Parameter HR [95% CI] p-value
O15_ICP_EXMORE 0.646 [0.5, 0.83] < 0.001
Birth year 0.997 [0.99, 1.01] 0.437

During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 13331 females with O15_ICP_EXMORE died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_ICP_EXMORE.

N-year risk Females Males
1 0.056% No data
5 0.38% No data
10 1.081% No data
15 1.972% No data
20 3.48% No data

Relationships between endpoints

Index endpoint: O15_ICP_EXMORE – Intrahepatic Cholestasis of Pregnancy (ICP) , excluding more controls

GWS hits: 33

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data