No definition available.
Intrahepatic Cholestasis of Pregnancy (ICP) , incl. ICD-8, excluding more controls
O15_ICP_WIDE_EXMORE
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
|
1. Apply sex-specific ruleonly females |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
- Control exclude
- !(O15_DELIVERY, O15_DELIVERY_PROXY)
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
- Parent code in ICD-10
- O26
- Name in latin
- Morbositates hepatis in graviditate, intra labores et/sive in puerperio
Similar endpoints
↥List of similar endpoints to
Intrahepatic Cholestasis of Pregnancy (ICP) , incl. ICD-8, excluding more controls
based on the number of shared cases.
Similar with more cases:
- Intrahepatic Cholestasis of Pregnancy (ICP) , incl. ICD-8
- Pregnancy, childbirth and the puerperium
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 23532 | 23532 | - |
Only index persons | 23124 | 23124 | - |
Unadjusted period prevalence (%) | |||
Whole population | 0.67 | 0.67 | - |
Only index persons | 0.85 | 0.85 | - |
Median age at first event (years) | |||
Whole population | - | 29.44 | - |
Only index persons | - | 29.44 | - |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 3612 | 3612 | - |
Unadjusted period prevalence (%) | 1.23 | 1.23 | - |
Median age at first event (years) | 29.60 | 29.60 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 3250
- Matched controls
- 32510
LabWAS
↥Mortality – FinRegistry
↥Association
Association between endpoint O15_ICP_WIDE_EXMORE and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
O15_ICP_WIDE_EXMORE | 0.645 [0.51, 0.82] | < 0.001 |
Birth year | 0.994 [0.99, 1.0] | 0.15 |
During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 13316 females with O15_ICP_WIDE_EXMORE died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have O15_ICP_WIDE_EXMORE.N-year risk | Females | Males |
---|---|---|
1 | 0.056% | No data |
5 | 0.347% | No data |
10 | 0.859% | No data |
15 | 1.645% | No data |
20 | 2.956% | No data |
Relationships between endpoints
↥Index endpoint: O15_ICP_WIDE_EXMORE – Intrahepatic Cholestasis of Pregnancy (ICP) , incl. ICD-8, excluding more controls
GWS hits: 29