Intrahepatic Cholestasis of Pregnancy (ICP) , incl. ICD-8, excluding more controls

O15_ICP_WIDE_EXMORE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

only females

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O26.6
  • Hospital discharge: ICD-9 6467
  • Hospital discharge: ICD-8 6390
  • Cause of death: ICD-10 O26.6
  • Cause of death: ICD-9 6467
  • Cause of death: ICD-8 6390

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude
!(O15_DELIVERY, O15_DELIVERY_PROXY)

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Parent code in ICD-10
O26
Name in latin
Morbositates hepatis in graviditate, intra labores et/sive in puerperio

Similar endpoints

List of similar endpoints to Intrahepatic Cholestasis of Pregnancy (ICP) , incl. ICD-8, excluding more controls based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 23532 23532 -
Only index persons 23124 23124 -
Unadjusted period prevalence (%)
Whole population 0.67 0.67 -
Only index persons 0.85 0.85 -
Median age at first event (years)
Whole population - 29.44 -
Only index persons - 29.44 -

-FinnGen-

Key figures

All Female Male
Number of individuals 3612 3612 -
Unadjusted period prevalence (%) 1.23 1.23 -
Median age at first event (years) 29.60 29.60 -

-FinRegistry-

Age distribution of first events

02030400k1k2k3k4k5k6k7k8k9k10k11kAgeIndividuals

-FinnGen-

Age distribution of first events

01020304050607080900.0k0.2k0.4k0.6k0.8k1.0k1.2k1.4k1.6k1.8kAgeIndividuals

-FinRegistry-

Year distribution of first events

1970197519801985199019952000200520102015202020220.0k0.5k1.0k1.5k2.0k2.5k3.0kYearIndividuals

-FinnGen-

Year distribution of first events

197019751980198519901995200020052010201520202023050100150200250300350400450500YearIndividuals

-FinRegistry-

Cumulative Incidence Function

01020304050607080901000.00.20.40.60.81.01.21.41.61.82.0AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

01020304050607080901000.00.20.40.60.81.01.21.41.61.82.02.22.42.62.83.0AgeProbability of first incidence (%)

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
3250
Matched controls
32510
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A05AA02
ATC
ursodeoxycholic acid; oral
69.2
323.0
809
155
63900
ICD-8 Finland
Other toxaemias of pregnancy and the puerperium, Pruritus
+∞
323.0
568
*
6467A
ICD-9 Finland
Other complications of pregnancy, not elsewhere classified, Liver disorders in pregnancy[HEPATOSIS GRAVIDARUM]
+∞
323.0
680
*
O26.6
ICD-10 Finland
Liver disorders in pregnancy, childbirth and the puerperium
16384.0
323.0
2068
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.0
59.6
370
1316
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
2.3
47.9
481
2244
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.3
45.1
482
2314
63998
ICD-8 Finland
Other toxaemias of pregnancy and the puerperium, Alia definitae
16.9
44.3
71
43
O80.8
ICD-10 Finland
Other single spontaneous delivery
2.2
32.5
377
1864
63901
ICD-8 Finland
Other toxaemias of pregnancy and the puerperium, Interus gravis
+∞
27.1
26
*
63909
ICD-8 Finland
Other toxaemias of pregnancy and the puerperium, Necrosis acuta et subacuta hepatis
+∞
25.0
24
*
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
1.7
24.1
636
4157
MAC10
NOMESCO Finland
Antepartum dilatation of cervical canal
2.4
23.3
206
892
O30.0
ICD-10 Finland
Twin pregnancy
2.8
22.9
149
542
W84
ICPC
Pregnancy high risk
2.0
20.4
276
1444
MAC01
NOMESCO Finland
Rupture of aminiotic membrane for induction of labor
2.5
19.4
154
631
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
1.4
18.7
1040
8003
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
3.6
17.9
82
234
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
1.6
17.8
575
3928
5742A
ICD-9 Finland
Cholelithiasis, Calculus of gallbladder without mention of cholecystitis[CHOLECYSTOLITHIASIS SINE CHOLECYSTITIDE,SINE OBSTR]
3.6
17.7
80
226
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
4.0
17.1
69
177
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
1.5
16.4
585
4084
MAC96
NOMESCO Finland
Other induction or advancement of labour
2.0
14.3
182
932
O60
ICD-10 Finland
Preterm labour and delivery
1.9
12.5
180
963
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
1.4
11.9
564
4148
L29.9
ICD-10 Finland
Pruritus, unspecified
2.6
11.9
87
345
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
1.9
11.4
173
946
MAA00
NOMESCO Finland
Amniocentesis
2.0
11.3
153
803
6663
FHL
Cholecystectomy and cholangiography
3.7
11.1
47
128
XMA22
NOMESCO Finland
General examination of pregnant woman
1.5
10.9
367
2512
A10BX01
ATC
guar gum; systemic
2.7
10.8
70
260
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.3
10.6
1172
9856
6510B
ICD-9 Finland
Multiple gestation, Twin pregnancy[GEMINI, SYNNYTYKSEN AIKANA]
3.7
10.3
43
117
K76.9
ICD-10 Finland
Liver disease, unspecified
3.2
10.2
51
159
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.5
9.9
306
2054
MAC40
NOMESCO Finland
Pharmacological induction or advancement of labor
2.0
9.5
124
646
6467X
ICD-9 Finland
Other complications of pregnancy, not elsewhere classified, Liver disorders in pregnancy[HEPATOPATHIA ALIA GRAVIDARUM]
+∞
9.4
9
*
Z35.9
ICD-10 Finland
Supervision of high-risk pregnancy, unspecified
1.7
9.3
211
1311
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
1.5
9.3
361
2552
63902
ICD-8 Finland
NA
+∞
8.3
8
*
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.4
8.2
480
3652
L04AX01
ATC
azathioprine; systemic
1.9
8.2
114
608
O13
ICD-10 Finland
Gestational [pregnancy-induced] hypertension
1.5
8.1
268
1826
S02
ICPC
Pruritus
2.0
8.0
100
511
K80.1
ICD-10 Finland
Calculus of gallbladder with other cholecystitis
2.5
8.0
62
255
6510A
ICD-9 Finland
Multiple gestation, Twin pregnancy[GEMINI, RASKAUDEN AIKANA]
4.1
8.0
29
71
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
1.8
7.9
129
727
1413
FHL
Laparoscopy and other therapeutic procedure
2.1
7.9
88
432
O36.6
ICD-10 Finland
Maternal care for excessive fetal growth
1.6
7.8
221
1455
O84.2
ICD-10 Finland
Multiple delivery, all by caesarean section
3.2
7.7
38
120
V230A
ICD-9 Finland
Supervision of high-risk pregnancy, Pregnancy with history of infertility
2.5
7.6
57
232
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
4.2
7.6
27
65
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
1.3
7.6
979
8310
G03DA04
ATC
progesterone; systemic, rectal, vaginal
1.7
7.4
148
891
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
1.3
7.3
628
5054
O26.0
ICD-10 Finland
Excessive weight gain in pregnancy
5.8
7.2
19
33
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.3
7.2
579
4618
8811
FHL
Cesarean section
1.5
7.2
254
1757
K50.9
ICD-10 Finland
Crohn disease, unspecified
2.6
7.1
47
180
O98.4
ICD-10 Finland
Viral hepatitis complicating pregnancy, childbirth and the puerperium
6.0
7.1
18
30
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
3.4
7.0
32
96
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
1.9
7.0
100
542
K83.9
ICD-10 Finland
Disease of biliary tract, unspecified
6.3
6.9
17
27
O61.0
ICD-10 Finland
Failed medical induction of labour
2.2
6.9
69
324
O84.0
ICD-10 Finland
Multiple delivery, all spontaneous
2.7
6.9
45
170
K83.0
ICD-10 Finland
Cholangitis
3.2
6.8
33
104
A02BC02
ATC
pantoprazole; systemic
1.2
6.8
1732
15754
B18.2
ICD-10 Finland
Chronic viral hepatitis C
2.9
6.6
36
123
O14.9
ICD-10 Finland
Pre-eclampsia, unspecified
2.0
6.5
84
436
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
3.5
6.5
28
81
6662
FHL
Cholecystectomy
3.0
6.5
34
114
Z22.5
ICD-10 Finland
Carrier of viral hepatitis
14.3
6.4
10
7
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
1.9
6.4
85
450
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.3
6.2
616
5050
K30
ICD-10 Finland
Functional dyspepsia
1.4
6.0
282
2065

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
810
1205
8.38
307.65
6.2
1.5
10.01
4.09
umol/l
19.22
714
846
292
580
5.39
140.26
1.3
1.3
108.05
108.98
u/ml
0.07
56
146
293
592
5.30
138.03
1.2
1.2
203.38
263.87
u/ml
4.48
235
383
304
635
5.14
137.87
1.3
1.3
—
—
—
0
0
302
640
5.06
134.62
1.3
1.3
14.08
17.13
u/ml
—
5
17
356
1201
3.18
81.78
1.2
1.2
—
—
—
0
0
540
3139
1.85
34.28
2.4
2.4
5.98
6.17
umol/l
0.10
477
2675
722
4728
1.66
29.71
1.6
1.5
—
—
—
0
0
1774
14201
1.49
29.55
5.2
5.4
9.58
9.52
umol/l
0.11
1678
13393
1319
10028
1.50
27.84
3.5
2.9
33.59
29.45
u/l
2.18
1263
9593
195
840
2.40
27.42
1.4
1.2
667.78
1046.51
titre
—
9
43
193
839
2.37
26.59
1.4
1.2
72.00
184.25
titre
0.82
15
73
2486
21829
1.45
22.17
7.6
6.7
79.16
72.43
u/l
13.32
2348
20634
299
1700
1.83
19.95
1.8
1.8
1.48
1.36
g/l
0.32
273
1571
3445
32782
2.11
19.91
11.3
8.7
30.86
23.70
u/l
37.37
3375
31877
363
2235
1.69
18.32
2.4
2.6
10.45
10.34
g/l
0.24
331
2052
1151
9387
1.33
13.56
6.2
5.6
—
—
—
0
0
325
2098
1.60
13.53
2.2
2.1
0.22
0.22
g/l
0.28
301
1981
1574
13508
1.29
12.47
8.4
7.9
0.00
0.00
e9/l
1.20
1300
11164
668
5075
1.39
12.27
1.5
1.4
686.99
610.51
titre
0.34
143
1043
2395
21747
1.30
12.03
3.3
2.7
40.07
34.67
u/l
3.28
2267
20752
884
7046
1.34
11.90
1.5
1.4
2.08
2.13
g/l
0.63
557
4472
1606
13910
1.28
11.51
6.4
5.5
2.85
2.82
%
0.25
1525
12932
1614
13989
1.28
11.50
6.6
5.7
8.03
7.90
%
1.03
1546
13135
1550
13393
1.28
11.23
6.5
5.5
0.73
0.69
%
1.96
1480
12469
99
472
2.13
11.08
1.1
1.1
—
—
—
0
0
1086
8983
1.30
11.06
2.4
2.4
59.07
55.95
u/l
0.42
1019
8360
835
6693
1.32
10.64
4.0
3.1
99.38
98.68
%
0.41
807
6470
1658
14508
1.26
10.60
6.4
5.5
29.95
29.81
%
0.25
1578
13565
107
539
2.02
10.36
1.9
1.4
9.03
6.32
iu/ml
—
6
9
1635
14324
1.26
10.21
6.2
5.3
56.05
56.29
%
0.42
1565
13427
100
496
2.05
10.11
1.1
1.1
—
—
—
0
0
1689
14887
1.25
9.89
6.3
5.4
0.52
0.52
e9/l
0.39
1506
13133
1039
8646
1.28
9.88
4.7
5.3
1.05
1.07
inr
0.65
360
2916
56
223
2.54
9.52
1.1
1.1
315.49
289.81
mg/l
0.93
45
200
1691
14952
1.25
9.47
6.3
5.4
0.04
0.04
e9/l
1.00
1509
13163
1260
10785
1.26
9.38
4.6
4.2
36.37
36.63
g/l
0.99
1173
10112
49
192
2.57
8.64
1.3
1.3
272.86
176.88
titre
0.34
14
48
1725
15413
1.23
8.35
6.3
5.3
1.93
1.96
e9/l
0.65
1574
13892
500
3874
1.34
7.87
2.1
2.1
14.41
14.46
umol/l
0.06
466
3610
1732
15551
1.22
7.78
6.4
5.4
0.18
0.18
e9/l
0.12
1577
13968
1888
17106
1.22
7.71
3.2
2.9
64.71
71.83
ug/l
2.59
1798
16216
47
193
2.45
7.57
1.1
1.0
—
—
—
0
0
72
358
2.03
7.34
1.0
1.1
1.41
1.45
g/l
0.39
61
321
403
3064
1.35
7.18
2.2
2.2
23.41
23.86
%
0.26
347
2647
2449
22852
1.22
7.14
4.4
3.8
10.28
9.86
mm/h
1.09
2317
21576
344
2552
1.38
7.14
2.5
2.2
35.34
35.74
u/l
0.04
312
2184
929
7875
1.24
7.14
3.0
2.7
34.21
72.23
e6/l
1.22
679
5914
146
910
1.63
7.11
2.2
1.5
6.62
6.99
u/ml
—
6
21
2410
22459
1.22
7.09
4.5
4.0
—
—
—
0
0
1451
12928
1.20
6.71
2.4
2.2
76.94
76.11
nmol/l
0.57
1347
12064
49
218
2.26
6.64
1.1
1.0
—
—
—
0
0
823
6936
1.24
6.60
2.3
2.1
2.56
2.70
mg/l
1.15
727
6004
112
668
1.70
6.48
4.3
3.5
780.16
389.18
u/ml
0.31
97
569
443
3476
1.31
6.35
2.2
2.1
2.48
2.47
g/l
0.07
407
3220
1123
9827
1.21
6.16
1.8
1.8
102.45
100.02
pmol/l
0.89
569
5200
844
7180
1.23
6.15
3.0
2.6
0.20
0.30
e6/l
1.45
617
5307
128
805
1.61
6.06
2.0
1.9
1.21
1.35
g/l
1.04
110
700
994
8610
1.21
6.04
1.3
1.3
1.02
1.56
u/ml
2.06
288
2578
391
3039
1.32
5.99
1.2
1.2
—
—
—
0
0
604
4970
1.26
5.94
2.6
2.4
525.19
523.23
mosm/kgh2o
0.07
515
4230
87
497
1.77
5.90
1.6
1.6
0.49
0.65
g/l
1.28
70
373
3118
30054
1.27
5.78
5.3
5.1
1.69
1.89
mu/l
1.38
2951
28480
45
206
2.20
5.75
1.4
1.3
—
—
—
0
0
35
146
2.41
5.53
2.9
2.9
8.55
7.61
mg/l
0.33
28
106
837
7185
1.21
5.50
2.9
2.6
—
—
—
0
0
1865
17180
1.18
5.48
8.4
7.9
3.83
3.89
e9/l
0.64
1660
15162
2856
27306
1.22
5.45
13.9
12.4
13.45
13.47
%
0.25
2821
26804
768
6543
1.22
5.44
1.3
1.3
10.26
9.54
u/ml
0.13
294
2828
1357
12235
1.17
5.06
5.4
5.3
1.22
1.22
mmol/l
1.36
1159
10343
471
3857
1.25
4.80
2.6
2.4
4.87
4.73
e6/l
0.06
238
2004
785
6807
1.20
4.55
1.3
1.3
25.61
27.54
iu/ml
0.17
235
2189
1117
9986
1.17
4.51
3.6
3.2
69.50
74.95
e6/l
0.12
744
6571
2792
26776
1.19
4.46
4.7
4.5
14.38
14.36
pmol/l
0.19
2608
25277
485
4018
1.24
4.45
1.2
1.2
—
—
—
0
0
611
5186
1.21
4.44
1.4
1.4
21.86
21.52
nmol/l
0.22
528
4558
393
3193
1.26
4.29
1.4
1.3
—
—
—
0
0
562
4750
1.22
4.25
3.0
2.3
97.07
102.01
ug/g
0.19
451
3719
1203
10866
1.16
4.19
5.1
4.7
1.22
1.22
mmol/l
1.57
1130
9914
427
3520
1.24
4.10
1.8
1.8
—
—
—
0
0
1097
9858
1.16
4.07
2.0
1.8
—
—
—
0
0
777
6822
1.18
3.84
2.2
2.1
615.94
2716.69
umol/l
5.09
683
6068
63
1020
0.61
3.75
6.6
7.3
—
—
—
0
0
642
5564
1.19
3.70
2.5
2.3
9.28
8.18
e6/l
0.30
546
4819
46
255
1.81
3.58
1.1
1.2
—
—
—
0
0
3314
32448
1.26
3.56
12.1
11.0
66.02
65.95
umol/l
0.08
3309
32436
51
293
1.75
3.53
4.0
3.2
—
—
—
0
0
361
2973
1.24
3.52
1.4
1.4
—
—
—
0
0
46
257
1.80
3.50
1.0
1.1
8.09
10.63
iu/ml
0.28
12
68
3132
30501
1.20
3.47
11.0
10.1
3.89
3.90
mmol/l
1.03
3061
29664
109
756
1.46
3.45
1.2
1.2
—
—
—
0
0
98
668
1.48
3.39
1.1
1.1
—
—
—
0
0
3122
30408
1.20
3.38
10.9
10.0
139.69
139.64
mmol/l
0.53
3050
29655
400
3350
1.22
3.33
2.4
2.0
29.01
28.94
s
0.08
383
3230
488
4176
1.19
3.24
2.5
2.3
2.25
1.07
e6/l
0.59
254
2309
309
2534
1.24
3.15
1.3
1.3
196.80
147.83
u/ml
0.28
291
2356
813
7265
1.15
3.15
1.9
1.7
1.03
0.89
mg/l
0.76
600
5420
29
144
2.02
3.15
1.2
1.2
—
—
—
0
0
354
2952
1.22
3.09
1.9
2.1
380.51
367.82
nmol/l
0.61
332
2735
806
7219
1.15
3.02
1.9
1.9
133.42
138.52
u/l
0.12
772
6855
61
389
1.58
2.91
2.0
1.7
36.00
23.37
iu/ml
—
5
19
108
778
1.40
2.84
2.7
2.7
—
—
—
0
0
1156
10647
1.13
2.79
2.0
2.0
—
—
—
0
0
422
3616
1.19
2.78
3.1
3.1
0.83
0.82
mmol/l
0.97
398
3401
42
247
1.71
2.75
2.2
2.2
—
—
—
0
0
239
1942
1.25
2.69
2.0
2.6
1.64
1.72
%
0.70
210
1748
2968
28902
1.15
2.68
3.7
3.6
5.60
5.60
mmol/l
0.10
2774
27141
323
2711
1.21
2.67
2.7
3.4
4.56
4.54
pmol/l
0.14
297
2449
2288
21936
1.12
2.64
4.5
4.1
654.22
1705.32
e6/l
0.85
23
234
2687
26011
1.13
2.60
4.6
4.3
37.49
37.56
mmol/mol
0.19
2536
24575
806
7299
1.13
2.53
1.6
1.6
1.25
1.33
mmol/l
1.69
706
6306
1021
9388
1.12
2.49
3.3
2.9
—
—
—
0
0
1716
16234
1.11
2.48
4.2
3.8
6.20
6.26
mmol/l
0.65
1553
14438
201
1618
1.26
2.47
1.2
1.3
0.29
1.07
u/ml
2.22
16
135
163
1285
1.28
2.39
1.7
1.7
—
—
—
0
0
169
2116
0.79
2.38
3.1
3.2
—
—
—
0
0
87
625
1.40
2.38
1.2
1.1
12.11
11.61
au/ml
0.03
12
36
803
7300
1.13
2.36
6.5
6.1
—
—
—
0
0
278
2331
1.21
2.35
4.6
3.9
1.12
0.95
%
0.27
59
504
518
4578
1.15
2.33
2.5
2.5
669.35
566.53
ng/l
0.24
419
3745
83
594
1.41
2.33
2.3
2.4
9.83
10.29
g/l
0.68
77
516
276
2315
1.21
2.32
1.2
1.2
—
—
—
0
0
792
7201
1.13
2.32
3.4
3.4
7.39
7.40
ph
1.87
162
1435
82
588
1.40
2.28
2.5
2.7
—
—
—
0
0
71
497
1.44
2.26
1.8
1.6
16640.50
6809.71
e6/l
0.78
52
367
40
247
1.63
2.24
1.2
1.3
—
—
—
0
0
50
747
0.66
2.20
4.2
4.3
—
—
—
0
0
73
517
1.42
2.19
1.3
1.4
—
—
—
0
0
53
353
1.51
2.17
1.4
1.3
—
—
—
0
0
350
3022
1.18
2.15
3.6
3.4
—
—
—
0
0
181
1467
1.25
2.14
7.6
6.7
7.82
7.18
mmol/l
0.73
173
1421
266
2243
1.20
2.14
4.7
3.9
0.22
0.23
%
0.03
55
467
71
504
1.42
2.11
2.3
2.1
39.02
38.86
g/l
0.09
66
454
185
1509
1.24
2.07
2.2
2.6
66.86
67.13
g/l
0.21
171
1396
9
31
2.91
2.07
1.0
1.2
—
—
—
0
0
731
6670
1.12
2.01
2.8
2.8
—
—
—
0
0
255
2158
1.20
1.99
4.8
3.9
0.09
0.45
%
0.64
47
401
1104
10303
1.10
1.99
2.1
1.9
—
—
—
0
0
127
1000
1.28
1.94
1.3
1.3
6.34
7.95
u/ml
0.18
16
174
117
914
1.29
1.91
1.3
1.3
72.23
39.48
u/ml
—
9
97
954
8856
1.10
1.90
2.9
3.1
2.35
2.35
mmol/l
0.14
839
7968
7
22
3.19
1.88
2.1
2.4
—
—
—
0
0
420
3722
1.15
1.85
1.7
1.6
1126.46
1193.30
nmol/l
0.91
339
2974
6
17
3.53
1.83
1.0
1.2
—
—
—
0
0
48
326
1.48
1.83
2.2
2.8
1.62
1.41
%
0.21
41
254
80
1062
0.75
1.83
1.3
1.3
2.93
4.05
ug/l
1.53
74
976
13
262
0.49
1.81
1.2
1.5
—
—
—
0
0
13
262
0.49
1.81
1.2
1.5
—
—
—
0
0
13
262
0.49
1.81
1.2
1.5
—
—
—
0
0
13
262
0.49
1.81
1.2
1.5
—
—
—
0
0
84
632
1.34
1.80
3.6
3.6
57.35
57.06
%
0.09
84
632
124
984
1.27
1.80
1.3
1.3
6.51
5.62
u/ml
0.08
11
99
751
6910
1.11
1.77
3.7
3.0
7.28
7.28
mmol/l
0.01
652
5980
15
74
2.03
1.74
2.5
2.5
—
—
—
0
0
5
13
3.85
1.71
1.0
1.2
—
—
—
0
0
5
13
3.85
1.71
1.0
1.2
—
—
—
0
0
52
365
1.43
1.70
1.1
1.1
—
—
—
0
0
144
1173
1.24
1.69
2.2
2.3
—
—
—
0
0
3207
31583
1.14
1.69
11.8
10.4
17.16
18.38
mg/l
1.54
2504
24597
670
6145
1.11
1.68
4.4
3.8
9.34
9.61
mg/mmol
0.06
408
3722
76
571
1.34
1.67
1.2
1.2
—
—
—
0
0
29
180
1.62
1.66
1.1
1.3
—
—
—
0
0
292
2543
1.16
1.66
2.3
2.3
19.54
22.96
au/ml
0.29
12
191
3377
33390
1.18
1.63
10.7
9.9
—
—
—
0
0
54
387
1.40
1.59
2.4
2.6
14.83
93.18
ug/min
3.26
37
240
15
77
1.95
1.59
1.4
7.2
11863.60
63.89
mg/l
—
10
54
46
321
1.44
1.57
1.4
1.3
—
—
—
0
0
130
1057
1.24
1.57
2.3
2.0
0.23
0.23
g/l
0.14
125
998
383
3415
1.14
1.57
2.6
2.2
6722.92
6853.20
u/l
0.03
168
1552
16
85
1.89
1.54
1.9
2.4
—
—
—
0
0
23
138
1.67
1.51
2.5
2.2
9.56
11.09
%
1.19
23
138
43
299
1.44
1.51
1.3
1.2
—
—
—
0
0
96
1207
0.79
1.50
1.3
1.2
12.36
12.17
u/l
0.04
80
1039
3034
29834
1.11
1.45
12.9
10.9
39.28
39.34
%
0.21
2473
23984
384
3444
1.13
1.45
1.2
1.2
179.40
158.31
iu/ml
0.41
152
1428
639
5894
1.10
1.45
3.6
3.1
381.71
543.24
mg/l
0.37
391
3514
996
9374
1.09
1.44
2.5
2.5
—
—
—
0
0
18
102
1.77
1.44
31.3
23.9
111.50
112.98
ug/l
0.03
18
83
19
110
1.73
1.42
1.2
1.1
—
0.17
g/l
—
0
6
156
1309
1.20
1.41
2.3
2.5
72.20
100.51
ng/l
1.89
137
1180
135
1117
1.22
1.41
1.3
1.3
85.86
31.18
u/ml
—
5
85
246
2145
1.16
1.41
4.2
3.7
0.68
0.60
%
0.17
44
374
1308
12464
1.08
1.38
2.4
2.3
—
—
—
0
0
136
1132
1.21
1.35
1.7
2.1
3.25
4.30
iu/l
1.67
47
461
107
869
1.24
1.35
13.8
7.7
24.02
24.10
mmol/l
0.10
102
824
3043
29954
1.10
1.33
3.8
3.6
4.81
4.88
mmol/l
4.51
2903
28459
49
359
1.37
1.32
1.5
1.5
—
—
—
0
0
47
342
1.38
1.32
3.5
2.8
29.34
33.95
umol/l
1.29
38
301
592
5471
1.10
1.30
1.6
1.5
15238528.58
36880165.23
pmol/l
0.69
525
4756
47
343
1.38
1.30
1.1
1.5
—
2933.33
—
0
6
258
2278
1.14
1.27
2.3
2.2
3.71
4.05
e9/l
2.19
212
1921
57
431
1.33
1.26
2.9
2.6
—
—
—
0
0
343
3085
1.12
1.26
3.7
3.6
33.20
32.98
%
0.15
256
2300
188
1624
1.17
1.25
9.4
5.4
1.20
1.23
mmol/l
0.18
183
1571
16
92
1.74
1.25
1.1
1.1
—
—
—
0
0
93
752
1.24
1.24
2.0
2.1
10.33
10.12
mg/l
0.10
87
711
49
364
1.35
1.23
2.8
2.5
—
—
—
0
0
35
491
0.71
1.22
1.5
1.4
32.56
30.58
nmol/l
0.15
28
442
462
4233
1.10
1.22
3.0
2.8
284.90
283.68
ng/l
0.00
255
2296
267
2372
1.14
1.20
3.2
3.4
—
—
—
0
0
20
124
1.62
1.20
1.1
1.1
—
—
—
0
0
103
847
1.22
1.19
1.1
1.1
—
—
—
0
0
37
264
1.41
1.18
1.7
1.6
53.33
50.62
%
0.14
24
156
258
2292
1.14
1.17
10.9
13.0
1.08
1.10
inr
0.14
51
413
15
249
0.60
1.17
1.5
1.1
—
—
—
0
0
52
394
1.32
1.16
1.6
1.5
—
—
—
0
0
17
102
1.67
1.16
2.6
1.7
—
—
—
0
0
298
2674
1.12
1.16
5.2
4.6
1.05
1.04
mmol/l
0.40
279
2504
814
7667
1.08
1.15
4.5
3.9
—
—
—
0
0
447
4102
1.10
1.15
1.2
1.2
—
—
—
0
0
5
20
2.50
1.15
1.0
1.0
—
—
—
0
0
159
1367
1.17
1.14
2.1
2.6
65.81
72.15
e9/l
1.80
112
1013
261
2326
1.13
1.13
7.9
5.9
104.96
104.74
mmol/l
0.46
256
2281
45
335
1.35
1.13
1.7
1.5
—
—
—
0
0
329
2974
1.12
1.13
1.3
1.4
—
—
—
0
0
93
1129
0.82
1.12
5.8
7.1
24.84
24.45
mmol/l
0.53
84
1056
183
1593
1.16
1.12
1.7
1.8
—
—
—
0
0
11
58
1.90
1.12
6.8
4.8
—
—
—
0
0
922
8739
1.07
1.10
2.6
2.6
25.88
29.06
ng/l
0.16
385
3956
231
2047
1.14
1.10
3.2
3.2
1.23
1.23
mmol/l
0.79
211
1786
1682
16266
1.06
1.10
3.5
3.3
0.00
0.00
estimate
0.69
395
3293
84
684
1.23
1.08
1.1
1.1
—
—
—
0
0
3065
30244
1.09
1.08
4.0
3.9
2.88
2.93
mmol/l
2.91
2897
28536
807
7620
1.08
1.07
2.0
1.9
—
—
—
0
0
84
685
1.23
1.07
1.1
1.1
—
—
—
0
0
1431
13779
1.06
1.06
2.0
2.0
—
—
—
0
0
97
804
1.21
1.06
4.5
3.2
23.93
24.26
mmol/l
0.48
84
717
57
446
1.28
1.03
2.9
2.8
24.67
24.64
mmol/l
0.02
48
394
69
553
1.25
1.03
1.5
1.5
—
—
—
0
0
11
60
1.84
1.02
2.5
3.4
55.82
51.88
%
0.26
11
60
2904
28610
1.08
1.02
3.4
3.3
1.12
1.19
mmol/l
9.22
2765
27073
594
5557
1.08
1.01
3.7
3.6
—
—
—
0
0
7
134
0.52
0.98
1.7
1.1
—
—
—
0
0
0
29
0.00
0.97
0.0
1.1
—
17.90
—
0
10
627
5888
1.08
0.97
2.2
2.1
—
—
—
0
0
9
50
1.80
0.96
1.8
2.7
—
—
—
0
0
17
108
1.58
0.96
1.0
1.1
—
—
—
0
0
38
501
0.76
0.95
1.1
1.1
2.50
19990.67
iu/ml
—
6
134
45
347
1.30
0.93
1.2
1.4
—
—
—
0
0
354
3252
1.10
0.93
1.3
1.4
—
—
—
0
0
72
589
1.23
0.92
1.4
1.2
2.29
4.64
u/ml
2.46
28
221
6
28
2.14
0.91
1.0
2.6
—
—
—
0
0
112
957
1.18
0.91
12.6
8.6
—
—
—
0
0
58
464
1.25
0.91
3.6
2.6
2.11
2.29
mmol/l
0.21
31
297
11
63
1.75
0.90
1.2
1.1
—
—
u/ml
—
0
0
3019
29823
1.08
0.89
3.8
3.6
1.57
1.56
mmol/l
0.16
2874
28269
101
860
1.18
0.87
2.9
3.0
0.18
0.33
g/l
2.82
39
336
3539
35242
1.21
0.86
17.8
15.6
266.33
266.28
e9/l
0.02
3484
34641
161
1422
1.14
0.86
1.1
1.1
—
—
—
0
0
17
252
0.67
0.86
1.5
1.9
13.14
12.75
%
—
7
130
108
926
1.17
0.86
1.2
1.1
2.03
1.47
u/ml
0.29
38
333
704
7419
0.94
0.85
3.3
3.4
—
—
—
0
0
153
1348
1.14
0.85
3.0
2.8
—
—
—
0
0
90
763
1.18
0.82
1.1
1.1
1.74
1.51
u/ml
0.08
21
195
191
1711
1.12
0.82
3.4
3.0
72.99
72.03
ng/l
0.06
170
1521
69
571
1.21
0.82
2.3
2.3
—
—
—
0
0
288
2640
1.10
0.81
1.4
1.3
—
—
—
0
0
1952
19067
1.05
0.81
2.9
2.8
—
—
—
0
0
140
1231
1.14
0.81
1.2
1.2
—
—
—
0
0
1685
16400
1.05
0.80
4.9
4.5
0.00
0.00
estimate
0.80
405
3388
0
24
0.00
0.79
0.0
2.8
—
43.77
—
0
19
6
33
1.82
0.79
4.5
3.4
—
—
—
0
0
1696
16517
1.05
0.79
3.6
3.4
0.00
0.00
estimate
1.57
411
3360
0
26
0.00
0.78
0.0
1.0
—
—
—
0
0
15
98
1.53
0.78
1.1
1.6
—
—
—
0
0
52
420
1.24
0.78
1.5
1.5
—
2.38
—
0
8
131
1151
1.14
0.77
5.2
2.8
—
—
—
0
0
68
566
1.21
0.77
2.8
2.0
151.53
258.74
ug/l
0.83
58
501
28
208
1.35
0.77
3.6
2.4
—
—
—
0
0
672
7059
0.94
0.74
3.7
3.6
1.02
1.02
kg/l
0.26
117
1131
22
158
1.39
0.74
1.3
1.6
0.77
2.99
u/field
1.89
13
108
851
8158
1.06
0.72
1.8
1.7
—
—
—
0
0
146
1300
1.13
0.72
3.0
2.1
—
—
—
0
0
31
237
1.31
0.72
2.4
3.2
—
—
—
0
0
27
203
1.33
0.70
1.9
1.5
48.22
41.03
%
0.40
19
118
94
814
1.16
0.70
1.7
1.5
6.53
6.68
mmol/l
0.23
63
576
3539
35264
1.18
0.69
17.7
15.6
90.07
90.34
fl
3.40
3513
34986
3539
35264
1.18
0.69
17.7
15.6
29.91
30.06
pg
6.50
3513
34987
84
722
1.17
0.69
4.3
2.6
—
—
—
0
0
98
1121
0.87
0.67
4.2
5.2
—
—
—
0
0
3539
35268
1.17
0.66
17.8
15.7
6.61
6.69
e9/l
1.30
3481
34594
140
1252
1.12
0.66
3.1
2.6
4.73
4.60
kpa
0.24
134
1210
25
188
1.33
0.66
3.2
2.4
—
—
—
0
0
3539
35269
1.17
0.65
17.7
15.6
4.44
4.44
e12/l
0.10
3480
34626
93
810
1.15
0.65
1.9
1.9
—
—
—
0
0
2766
27986
0.95
0.65
14.8
13.0
331.10
331.88
g/l
5.18
2744
27813
10
62
1.61
0.65
1.0
1.2
—
—
—
0
0
5
29
1.73
0.64
1.2
2.3
0.60
0.86
u/field
—
5
29
8
128
0.62
0.64
1.8
1.5
—
—
—
0
0
125
1114
1.13
0.63
3.7
2.8
7.41
7.42
ph
0.65
17
155
163
1482
1.10
0.59
11.6
6.6
—
—
—
0
0
37
299
1.24
0.59
2.4
2.5
—
—
—
0
0
35
281
1.25
0.59
1.2
1.4
74.96
65.80
mmol/l
0.43
24
228
26
333
0.78
0.59
1.0
1.1
—
—
—
0
0
361
3397
1.07
0.58
1.3
1.3
28.57
28.17
iu/l
0.08
322
2996
87
762
1.15
0.58
1.4
1.3
324.91
310.62
ug/g
0.27
43
391
10
64
1.56
0.58
1.0
1.0
—
—
—
0
0
0
23
0.00
0.58
0.0
6.4
—
—
—
0
0
33
264
1.25
0.58
1.0
1.0
—
—
—
0
0
3539
35281
1.15
0.57
17.9
15.7
132.19
132.85
g/l
3.24
3515
34991
168
1534
1.10
0.57
2.8
2.0
—
—
—
0
0
8
55
1.46
0.56
2.1
1.7
—
—
—
0
0
113
1011
1.12
0.56
1.2
1.3
—
—
—
0
0
15
107
1.40
0.55
1.2
1.2
—
—
—
0
0
67
579
1.16
0.55
1.2
1.3
—
—
—
0
0
42
348
1.21
0.55
1.2
1.4
6.41
6.56
g/l
0.12
26
238
42
348
1.21
0.55
1.2
1.4
0.36
0.39
g/l
0.20
28
236
42
348
1.21
0.55
1.2
1.4
3.24
2.97
g/l
0.46
28
237
9
62
1.45
0.53
1.1
1.2
—
5.24
—
0
12
125
1131
1.11
0.52
3.7
2.8
5.12
5.12
kpa
0.02
113
1057
74
650
1.14
0.50
1.1
1.1
1.02
4.63
u/ml
5.71
31
258
236
2203
1.08
0.50
4.2
3.7
59.63
34.70
ug/l
0.24
179
1636
356
3372
1.06
0.49
1.5
1.6
—
—
—
0
0
135
1233
1.10
0.48
2.6
2.4
0.31
0.22
e6/l
0.42
128
1172
137
1253
1.10
0.47
2.3
2.3
—
—
—
0
0
129
1178
1.10
0.46
1.1
1.1
8.14
6.18
u/ml
0.10
18
179
33
273
1.21
0.46
1.1
1.2
0.62
1.31
u/ml
—
9
97
5
83
0.60
0.45
1.4
1.2
—
—
—
0
0
11
153
0.72
0.45
1.9
2.1
—
—
—
0
0
92
828
1.11
0.44
1.1
1.1
3.14
5.59
u/ml
1.20
42
418
157
1696
0.92
0.44
11.2
7.1
119.09
121.17
g/l
0.72
150
1634
81
725
1.12
0.43
3.3
5.1
1.75
1.72
%
0.06
75
675
127
1165
1.09
0.43
2.2
1.8
22.79
20.78
s
0.90
112
944
8
57
1.40
0.42
4.6
4.7
—
—
—
0
0
217
2038
1.07
0.41
1.7
1.5
410.86
284.41
mu/l
0.42
190
1800
25
305
0.82
0.41
1.5
2.3
1.54
1.35
e9/l
0.31
13
191
5
33
1.52
0.41
1.2
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
0.06
—
0
7
8
59
1.36
0.41
1.1
1.2
—
—
—
0
0
8
59
1.36
0.41
1.1
1.2
—
—
—
0
0
8
59
1.36
0.41
1.1
1.2
—
—
—
0
0
53
464
1.14
0.40
2.6
2.0
—
—
—
0
0
16
205
0.78
0.40
2.4
2.5
42.53
52.89
mg/l
0.09
11
137
166
1547
1.08
0.40
3.8
3.0
5.79
5.81
kpa
0.10
161
1497
61
687
0.89
0.39
3.8
5.7
1.18
1.17
mmol/l
0.05
53
605
55
484
1.14
0.39
3.4
3.4
—
—
—
0
0
5
35
1.43
0.39
1.2
1.2
—
—
—
0
0
5
35
1.43
0.39
1.0
1.1
—
—
—
0
0
25
205
1.22
0.39
1.6
1.9
0.70
2.11
u/field
—
10
99
0
19
0.00
0.39
0.0
1.7
—
—
—
0
0
73
655
1.12
0.39
1.1
1.2
—
—
—
0
0
86
779
1.11
0.39
1.1
1.1
0.81
1.30
u/ml
0.44
32
296
33
279
1.18
0.38
1.1
1.2
—
—
—
0
0
427
4102
1.05
0.38
1.5
1.5
—
—
—
0
0
5
36
1.39
0.38
1.0
1.0
—
—
—
0
0
9
68
1.32
0.37
1.0
1.1
—
—
—
0
0
63
562
1.12
0.37
3.4
2.7
7.41
7.43
ph
1.72
55
461
56
496
1.13
0.37
1.5
2.1
131.16
129.27
g/l
0.31
44
378
8
113
0.71
0.37
3.6
2.1
1.17
1.16
ug/l
—
8
108
126
1360
0.92
0.37
2.1
2.0
12.19
4.85
ug/l
1.24
110
1206
20
161
1.24
0.37
1.1
1.1
—
—
—
0
0
43
374
1.15
0.36
1.3
1.2
—
—
nmol/l
—
0
0
14
180
0.78
0.36
1.9
2.7
921.00
824.79
e6/l
—
8
75
104
955
1.09
0.36
1.8
1.6
7.31
7.53
mmol/l
0.44
67
571
24
198
1.21
0.36
3.0
2.5
58.06
55.95
%
0.17
17
130
11
81
1.36
0.36
2.0
1.5
—
—
—
0
0
201
1896
1.06
0.36
1.4
1.3
219.59
233.55
miu/ml
0.22
98
958
24
288
0.83
0.35
1.3
1.6
—
—
—
0
0
35
301
1.16
0.35
1.0
1.1
—
—
—
0
0
501
5181
0.96
0.34
1.4
1.4
—
—
—
0
0
47
414
1.14
0.34
2.3
2.1
—
—
—
0
0
10
73
1.37
0.34
1.1
1.5
—
—
—
0
0
6
44
1.36
0.34
1.0
1.1
—
—
—
0
0
44
386
1.14
0.34
1.2
1.2
—
—
—
0
0
18
145
1.24
0.33
1.1
1.2
—
—
—
0
0
6
90
0.67
0.32
1.0
1.4
—
—
—
0
0
441
4260
1.04
0.32
2.5
2.5
2.43
2.43
mmol/l
0.68
381
3717
19
155
1.23
0.32
1.1
1.1
—
—
—
0
0
10
74
1.35
0.32
1.2
1.4
—
—
—
0
0
232
2208
1.05
0.32
2.8
2.7
—
—
—
0
0
337
3240
1.04
0.31
1.5
1.5
—
—
—
0
0
57
513
1.11
0.31
1.5
1.5
10.96
10.18
mmol/l
—
8
42
163
1537
1.06
0.31
3.8
3.0
1.54
1.83
mmol/l
0.44
131
1267
24
202
1.19
0.31
1.2
1.1
—
—
—
0
0
7
96
0.73
0.30
1.1
1.4
—
—
—
0
0
76
696
1.09
0.30
1.1
1.1
1.35
5.18
u/ml
2.02
28
267
66
601
1.10
0.29
1.2
1.1
—
—
—
0
0
62
563
1.10
0.29
1.1
1.1
0.05
0.39
u/ml
0.66
14
117
7
56
1.25
0.29
1.4
1.7
—
—
—
0
0
7
57
1.23
0.29
1.3
1.1
—
—
—
0
0
241
2305
1.05
0.28
1.4
1.4
—
—
—
0
0
30
260
1.16
0.28
1.1
1.2
—
—
—
0
0
8
111
0.72
0.28
1.5
1.5
—
—
—
0
0
40
356
1.12
0.27
1.2
1.3
—
—
—
0
0
16
131
1.22
0.27
1.0
1.1
0.11
2.92
u/ml
—
8
64
19
159
1.20
0.26
1.2
1.2
—
—
—
0
0
12
95
1.26
0.26
1.1
1.2
—
—
—
0
0
42
377
1.12
0.25
2.9
1.5
—
—
—
0
0
179
1707
1.05
0.25
2.8
2.0
—
—
—
0
0
15
181
0.83
0.25
3.4
2.9
—
—
—
0
0
78
724
1.08
0.24
3.4
5.4
0.89
0.93
%
0.45
72
674
16
133
1.20
0.24
1.3
1.5
123.38
124.27
nmol/l
0.03
16
133
178
1701
1.05
0.23
2.7
1.8
—
—
—
0
0
20
171
1.17
0.23
1.1
1.1
—
—
—
0
0
5
38
1.32
0.23
1.2
1.1
—
—
—
0
0
48
438
1.10
0.22
1.4
1.3
1.17
1.30
nmol/l
0.33
34
371
22
191
1.15
0.21
1.1
1.1
12.88
7.43
u/ml
—
5
38
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
5.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
279.17
—
0
6
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
37
334
1.11
0.21
1.4
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
148
1549
0.95
0.21
1.2
1.2
—
—
—
0
0
19
219
0.87
0.20
4.0
2.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
0.24
—
0
9
9
114
0.79
0.20
1.1
2.0
—
—
—
0
0
48
442
1.09
0.19
3.8
3.9
31.85
45.02
mg/l
0.67
38
366
149
1428
1.05
0.19
1.7
1.7
—
—
—
0
0
44
404
1.09
0.19
1.9
2.1
16.94
16.65
%
0.17
20
199
176
1694
1.04
0.19
2.8
2.0
—
—
—
0
0
22
249
0.88
0.19
1.1
1.1
1688.55
1498.21
miu/ml
0.39
22
249
10
81
1.24
0.18
1.1
1.0
64.74
74.52
ug/l
—
10
73
12
143
0.84
0.18
2.3
1.4
1552.29
3358.25
e6/l
—
7
102
290
2980
0.97
0.18
1.7
1.7
—
—
—
0
0
10
121
0.83
0.18
2.5
1.5
—
—
—
0
0
7
61
1.15
0.17
1.6
1.6
11.24
59.38
u/l
—
7
55
15
129
1.16
0.17
1.1
1.1
—
—
—
0
0
5
70
0.71
0.16
1.0
1.0
—
—
—
0
0
26
288
0.90
0.16
5.4
5.1
376.42
373.52
umol/l
0.03
19
241
68
643
1.06
0.15
1.1
1.1
1.66
3.92
u/ml
2.17
36
326
9
79
1.14
0.15
1.6
1.8
—
—
—
0
0
23
255
0.90
0.15
4.5
4.9
6.84
6.61
mmol/l
0.10
16
210
9
80
1.13
0.15
1.0
1.1
—
—
—
0
0
9
80
1.13
0.15
1.0
1.0
—
—
—
0
0
9
80
1.13
0.15
1.0
1.1
—
—
—
0
0
37
342
1.08
0.15
1.0
1.1
180.18
205.06
mg/l
1.08
31
304
66
625
1.06
0.14
2.7
2.0
1.07
1.80
ug/l
0.50
58
564
260
2539
1.03
0.14
3.1
2.9
34.89
40.25
u/ml
0.23
250
2453
10
84
1.19
0.14
2.2
2.1
5.35
2.93
ug/l
—
10
77
71
676
1.05
0.13
1.2
1.3
—
—
—
0
0
47
442
1.06
0.13
3.9
3.9
22.46
43.21
mg/l
0.95
38
366
37
345
1.07
0.12
1.5
1.4
333.76
313.57
pmol/l
0.19
29
270
16
142
1.13
0.12
1.2
1.2
—
—
—
0
0
894
8850
1.01
0.12
3.6
3.6
0.01
0.00
estimate
0.54
406
3361
14
123
1.14
0.12
1.2
1.2
—
—
—
0
0
431
4379
0.98
0.12
1.3
1.3
—
—
—
0
0
10
85
1.18
0.12
2.3
2.0
7.39
2.60
ug/l
—
10
78
74
709
1.04
0.11
4.2
2.7
25.06
24.83
mmol/l
0.30
65
660
25
230
1.09
0.11
1.5
2.6
—
—
—
0
0
71
680
1.05
0.11
1.2
1.1
—
—
—
0
0
11
126
0.87
0.11
2.5
1.4
4733.00
66579.70
e6/l
—
5
71
26
240
1.08
0.11
1.1
1.1
428.19
399.90
nmol/l
0.28
21
228
15
134
1.12
0.11
1.7
3.8
—
—
—
0
0
15
167
0.90
0.10
1.1
3.4
—
—
—
0
0
196
2004
0.98
0.10
9.7
6.6
0.69
0.87
mmol/l
0.25
157
1544
25
269
0.93
0.10
1.1
1.1
—
—
—
0
0
18
164
1.10
0.09
2.9
1.9
—
—
—
0
0
13
145
0.90
0.09
1.2
1.3
—
—
—
0
0
168
1717
0.98
0.09
1.3
1.3
—
—
—
0
0
6
56
1.07
0.08
2.2
1.8
—
—
—
0
0
6
58
1.03
0.08
1.0
1.4
—
—
—
0
0
78
755
1.03
0.08
1.1
1.2
3.62
3.61
mmol/l
0.03
72
710
188
1845
1.02
0.08
1.3
1.4
—
—
—
0
0
7
64
1.09
0.08
1.6
2.4
—
—
—
0
0
72
744
0.97
0.08
1.5
1.6
—
—
—
0
0
7
65
1.08
0.08
1.0
1.2
—
—
—
0
0
6
71
0.84
0.07
1.3
2.7
18.08
15.37
umol/l
—
6
71
6
74
0.81
0.07
2.3
1.9
—
—
—
0
0
13
143
0.91
0.07
1.2
1.5
12.02
14.05
pmol/l
1.23
13
113
37
353
1.05
0.07
1.1
1.2
43.03
35.48
mg/l
0.25
28
296
14
153
0.91
0.07
2.2
1.4
37.14
35.39
g/l
0.22
14
140
58
600
0.97
0.07
3.4
3.4
30.72
21.43
mg/l
0.88
36
359
46
442
1.04
0.07
2.4
2.2
0.82
0.82
nmol/l
0.01
37
382
31
295
1.05
0.06
1.7
1.6
—
—
—
0
0
212
2090
1.02
0.06
1.2
1.2
—
—
—
0
0
29
305
0.95
0.06
1.9
1.8
—
—
—
0
0
23
244
0.94
0.06
4.8
6.4
—
—
—
0
0
22
207
1.06
0.06
1.6
2.2
31.27
32.11
pg
0.29
22
207
31
296
1.05
0.05
1.1
1.1
1.08
1.04
ratio
0.52
13
105
20
188
1.06
0.05
2.0
1.3
4818.21
85814.74
e6/l
1.10
14
125
103
1050
0.98
0.05
1.3
1.4
0.38
0.52
nmol/l
1.63
83
846
43
416
1.03
0.05
3.2
4.3
34.23
92.21
u/ml
—
9
133
172
1698
1.01
0.04
1.8
1.9
—
—
—
0
0
175
1770
0.99
0.04
10.4
6.9
95.86
96.39
%
0.41
168
1710
18
170
1.06
0.04
1.3
1.4
74.25
72.98
%
0.16
18
163
34
329
1.03
0.03
4.3
4.0
—
—
—
0
0
13
139
0.94
0.03
1.0
1.0
—
—
—
0
0
73
742
0.98
0.03
1.2
1.3
3.40
25.27
e6/l
3.32
52
565
26
269
0.97
0.02
1.1
1.2
—
—
—
0
0
80
789
1.01
0.02
4.7
2.8
—
—
—
0
0
1170
11678
1.00
0.02
2.1
1.8
—
—
—
0
0
94
929
1.01
0.02
1.2
1.1
—
—
—
0
0
260
2612
1.00
0.01
1.6
1.5
—
—
—
0
0
1640
16417
1.00
0.01
4.2
3.9
—
—
—
0
0
256
2569
1.00
0.01
1.5
1.5
—
—
—
0
0
12
114
1.05
0.00
2.3
1.5
—
—
—
0
0
107
1063
1.01
0.00
1.4
1.4
27.79
24.78
u/l
0.41
87
883
21
204
1.03
0.00
1.4
1.6
1.02
1.32
promille
0.43
15
144
22
214
1.03
0.00
1.1
1.4
—
—
—
0
0
175
1756
1.00
0.00
1.1
1.1
—
—
—
0
0
258
2574
1.00
0.00
1.5
1.5
—
—
—
0
0
21
208
1.01
0.00
1.5
2.9
—
—
—
0
0
10
95
1.05
0.00
12.7
13.4
1423.10
1326.15
nmol/l
—
10
89
12
125
0.96
0.00
1.3
1.9
—
—
—
0
0
13
125
1.04
0.00
1.4
1.8
—
—
—
0
0
14
135
1.04
0.00
1.5
1.3
5.78
6.48
mmol/l
0.85
14
128
43
428
1.00
0.00
4.5
7.5
105.18
105.33
mmol/l
0.06
38
383
43
428
1.00
0.00
4.5
7.5
11.50
10.86
mmol/l
0.83
38
383
74
742
1.00
0.00
1.2
1.4
1043.83
1964.17
e6/l
0.32
58
609
88
885
0.99
0.00
1.6
1.8
—
—
—
0
0
12
119
1.01
0.00
1.0
1.1
—
—
—
0
0
42
421
1.00
0.00
1.5
1.3
—
—
—
0
0
85
849
1.00
0.00
1.1
1.3
440.17
468.30
mg/l
0.25
78
811
200
2003
1.00
0.00
9.6
6.5
5.06
5.02
kpa
0.19
192
1926
200
2003
1.00
0.00
9.6
6.5
13.49
13.58
kpa
0.07
192
1922
13
127
1.02
0.00
2.4
1.5
—
—
—
0
0
16
163
0.98
0.00
1.3
1.4
1370.69
404.38
mu/l
0.39
16
156
0
5
0.00
0.00
0.0
1.0
—
0.25
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
9.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
8
79
1.01
0.00
1.1
2.2
—
—
—
0
0
5
58
0.86
0.00
4.4
2.3
109.20
146.72
nmol/l
—
5
50
5
51
0.98
0.00
1.6
1.2
79.80
84.45
ng/l
—
5
51
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
561.47
—
0
9
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
1403.99
—
0
7
0
5
0.00
0.00
0.0
1.0
—
11.08
—
0
5
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
5
49
1.02
0.00
1.0
1.7
—
—
—
0
0
6
64
0.94
0.00
1.0
1.0
—
—
—
0
0
5
52
0.96
0.00
1.2
1.1
—
—
—
0
0
9
92
0.98
0.00
7.4
9.8
854.78
702.98
nmol/l
—
9
87
0
6
0.00
0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
52
0.96
0.00
1.4
1.5
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint O15_ICP_WIDE_EXMORE and mortality.

Females

Parameter HR [95% CI] p-value
O15_ICP_WIDE_EXMORE 0.645 [0.51, 0.82] < 0.001
Birth year 0.994 [0.99, 1.0] 0.15

During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 13316 females with O15_ICP_WIDE_EXMORE died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_ICP_WIDE_EXMORE.

N-year risk Females Males
1 0.056% No data
5 0.347% No data
10 0.859% No data
15 1.645% No data
20 2.956% No data

Relationships between endpoints

Index endpoint: O15_ICP_WIDE_EXMORE – Intrahepatic Cholestasis of Pregnancy (ICP) , incl. ICD-8, excluding more controls

GWS hits: 29

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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