No definition available.
Intrahepatic Cholestasis of Pregnancy (ICP) , incl. ICD-8, excluding more controls
O15_ICP_WIDE_EXMORE
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleonly females |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
- Control exclude
- !(O15_DELIVERY, O15_DELIVERY_PROXY)
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
- Parent code in ICD-10
- O26
- Name in latin
- Morbositates hepatis in graviditate, intra labores et/sive in puerperio
Similar endpoints
↥List of similar endpoints to
Intrahepatic Cholestasis of Pregnancy (ICP) , incl. ICD-8, excluding more controls
based on the number of shared cases.
Similar with more cases:
- Intrahepatic Cholestasis of Pregnancy (ICP) , incl. ICD-8
- Pregnancy, childbirth and the puerperium
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 23532 | 23532 | - |
| Only index persons | 23124 | 23124 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.67 | 0.67 | - |
| Only index persons | 0.85 | 0.85 | - |
| Median age at first event (years) | |||
| Whole population | - | 29.44 | - |
| Only index persons | - | 29.44 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3563 | 3563 | - |
| Unadjusted period prevalence (%) | 1.26 | 1.26 | - |
| Median age at first event (years) | 29.67 | 29.67 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 3699
- Matched controls
- 36990
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A05AA02
ATC
ursodeoxycholic acid; oral
75.6
307.7
1027
187
O26.6
ICD-10 Finland
Liver disorders in pregnancy, childbirth and the puerperium
9382.5
307.7
2407
9
63900
ICD-8 Finland
Other toxaemias of pregnancy and the puerperium, Pruritus
+∞
307.7
626
*
6467A
ICD-9 Finland
Other complications of pregnancy, not elsewhere classified, Liver disorders in pregnancy[HEPATOSIS GRAVIDARUM]
+∞
307.7
733
*
63998
ICD-8 Finland
Other toxaemias of pregnancy and the puerperium, Alia definitae
24.6
108.6
77
32
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.7
77.1
455
1812
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
2.3
68.3
584
2759
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.3
64.2
580
2800
O80.8
ICD-10 Finland
Other single spontaneous delivery
2.0
38.1
459
2445
MAC10
NOMESCO Finland
Antepartum dilatation of cervical canal
2.3
33.1
253
1125
O30.0
ICD-10 Finland
Twin pregnancy
2.9
33.0
164
592
W84
ICPC
Pregnancy high risk
2.0
28.3
353
1896
63901
ICD-8 Finland
Other toxaemias of pregnancy and the puerperium, Interus gravis
+∞
28.2
27
*
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
1.6
27.9
746
4989
MAC01
NOMESCO Finland
Rupture of aminiotic membrane for induction of labor
2.4
26.1
189
821
63909
ICD-8 Finland
Other toxaemias of pregnancy and the puerperium, Necrosis acuta et subacuta hepatis
+∞
26.1
25
*
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
1.6
25.6
745
5074
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
3.3
25.4
95
291
5742A
ICD-9 Finland
Cholelithiasis, Calculus of gallbladder without mention of cholecystitis[CHOLECYSTOLITHIASIS SINE CHOLECYSTITIDE,SINE OBSTR]
3.4
23.2
83
247
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
3.1
23.1
96
314
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
1.4
22.1
1305
10220
L29.9
ICD-10 Finland
Pruritus, unspecified
2.6
22.1
130
513
MAC96
NOMESCO Finland
Other induction or advancement of labour
2.0
20.7
215
1081
O60
ICD-10 Finland
Preterm labour and delivery
2.0
18.6
209
1081
S02
ICPC
Pruritus
2.2
16.1
141
664
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
1.4
15.4
663
4847
K76.9
ICD-10 Finland
Liver disease, unspecified
3.2
15.3
61
195
O98.4
ICD-10 Finland
Viral hepatitis complicating pregnancy, childbirth and the puerperium
7.0
15.3
23
33
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
1.5
15.1
435
2931
XMA22
NOMESCO Finland
General examination of pregnant woman
1.5
14.1
442
3029
Z35.9
ICD-10 Finland
Supervision of high-risk pregnancy, unspecified
1.7
14.0
251
1503
6663
FHL
Cholecystectomy and cholangiography
3.4
13.7
49
147
K83.0
ICD-10 Finland
Cholangitis
3.8
13.6
40
105
6467X
ICD-9 Finland
Other complications of pregnancy, not elsewhere classified, Liver disorders in pregnancy[HEPATOPATHIA ALIA GRAVIDARUM]
+∞
13.5
13
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.3
12.9
1452
12276
K83.9
ICD-10 Finland
Disease of biliary tract, unspecified
6.2
12.5
21
34
MAA00
NOMESCO Finland
Amniocentesis
1.9
12.4
165
903
A10BX01
ATC
guar gum; oral
2.5
12.4
73
290
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
3.2
11.9
47
150
O84.0
ICD-10 Finland
Multiple delivery, all spontaneous
2.9
11.6
54
190
B18.2
ICD-10 Finland
Chronic viral hepatitis C
3.2
11.5
44
138
MAC40
NOMESCO Finland
Pharmacological induction or advancement of labor
1.8
11.2
166
942
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
1.4
11.2
674
5197
ZXE00
NOMESCO Finland
One hour or less
1.3
11.0
1386
11821
6510B
ICD-9 Finland
Multiple gestation, Twin pregnancy[GEMINI, SYNNYTYKSEN AIKANA]
3.1
10.9
45
148
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.5
10.8
376
2628
O36.6
ICD-10 Finland
Maternal care for excessive fetal growth
1.6
10.8
265
1720
57409
ICD-8 Finland
Cholelithiasis, Unspecified
3.6
10.5
34
96
63902, ,
ICD-8 Finland
+∞
10.4
10
*
V230A
ICD-9 Finland
Supervision of high-risk pregnancy, Pregnancy with history of infertility
2.5
10.2
61
244
K80.1
ICD-10 Finland
Calculus of gallbladder with other cholecystitis
2.3
10.0
71
308
O26.0
ICD-10 Finland
Excessive weight gain in pregnancy
4.8
10.0
22
46
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
1.3
10.0
1143
9606
8811
FHL
Cesarean section
1.5
9.9
279
1867
L29.8
ICD-10 Finland
Other pruritus
2.7
9.7
50
186
O13
ICD-10 Finland
Gestational [pregnancy-induced] hypertension
1.5
9.6
319
2211
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
3.6
9.5
30
83
Z2221
NOMESCO Finland
Medical doctor
1.3
9.5
950
7841
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
1.7
9.4
156
915
G03DA04
ATC
progesterone; systemic, rectal, vaginal
1.7
9.4
159
939
O48
ICD-10 Finland
Prolonged pregnancy
0.5
9.4
96
1806
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
3.3
8.9
32
97
ZXD10
NOMESCO Finland
Scheduled procedure
1.2
8.6
1156
9866
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
3.0
8.6
36
120
O84.2
ICD-10 Finland
Multiple delivery, all by caesarean section
2.8
8.5
41
148
A10AC01
ATC
insulin (human); parenteral
1.6
8.3
193
1236
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.3
8.3
634
5039
L04AX01
ATC
azathioprine; systemic
1.7
7.8
128
750
1413
FHL
Laparoscopy and other therapeutic procedure
1.9
7.8
91
480
O14.9
ICD-10 Finland
Pre-eclampsia, unspecified
1.8
7.8
102
559
6510A
ICD-9 Finland
Multiple gestation, Twin pregnancy[GEMINI, RASKAUDEN AIKANA]
3.1
7.7
30
96
K30
ICD-10 Finland
Functional dyspepsia
1.4
7.6
387
2894
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
1.3
7.5
727
5954
K80.5
ICD-10 Finland
Calculus of bile duct without cholangitis or cholecystitis
2.0
7.5
81
417
6480A
ICD-9 Finland
Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Diabetes mellitus
2.9
7.4
34
120
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
2.2
7.3
55
247
Z87.5
ICD-10 Finland
Personal history of complications of pregnancy, childbirth and the puerperium
2.0
7.2
73
368
O26.9
ICD-10 Finland
Pregnancy-related condition, unspecified
2.3
7.0
48
206
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
1.4
7.0
259
1836
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
4.0
6.9
19
48
O14.0
ICD-10 Finland
Mild to moderate pre-eclampsia
1.7
6.8
115
681
K50.9
ICD-10 Finland
Crohn disease, unspecified
2.2
6.8
52
235
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
2.9
6.8
31
109
G03DB01
ATC
dydrogesterone; oral
1.3
6.7
640
5229
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.2
6.7
918
7814
K80.0
ICD-10 Finland
Calculus of gallbladder with acute cholecystitis
1.8
6.7
101
580
6662
FHL
Cholecystectomy
2.7
6.6
34
128
Z35.4
ICD-10 Finland
Supervision of pregnancy with grand multiparity
2.2
6.5
54
252
Z35
ICD-10 Finland
Supervision of high-risk pregnancy
1.9
6.4
74
390
O82.0
ICD-10 Finland
Delivery by elective caesarean section
1.4
6.4
306
2266
57401
ICD-8 Finland
Cholelithiasis, Cum cholecystitide chronica
3.4
6.4
22
65
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.4
6.4
233
1646
5740A
ICD-9 Finland
Cholelithiasis, Calculus of gallbladder with acute cholecystitis[CHOLECYSTOLITHIASIS CUM CHOLECYSTITIDE AC,SINE OBST]
4.1
6.3
17
42
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
6.5
6.3
15
23
A02BC05
ATC
esomeprazole; systemic
1.2
6.3
1239
10914
O99.80
ICD-10 Finland
The fear of childbirth
1.3
6.2
368
2818
B01AB04
ATC
dalteparin; parenteral
1.6
6.2
145
934
MBA00
NOMESCO Finland
Vacuum aspiration from uterus after delivery or abortion
1.6
6.1
123
763
MA2XE
NOMESCO Finland
Other obstetric ultrasound examination
1.3
6.1
448
3538
A10AB01
ATC
insulin (human); parenteral
1.8
6.0
87
493
Z71.8
ICD-10 Finland
Other specified counselling
1.2
6.0
1118
9787
A02BC01
ATC
omeprazole; systemic
1.2
6.0
815
6920
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
866
1278
8.54
307.65
6.1
1.5
10.13
3.98
umol/l
22.67
767
895
308
595
5.56
152.72
1.3
1.3
107.44
108.84
u/ml
0.11
58
155
310
609
5.46
150.86
1.2
1.2
199.72
266.00
u/ml
5.45
248
393
321
657
5.26
149.16
1.2
1.2
—
—
—
0
0
319
656
5.23
147.40
1.2
1.3
14.08
16.52
u/ml
—
5
18
120
173
7.14
79.27
1.1
1.1
—
—
—
0
0
547
3192
1.84
34.22
2.4
2.4
5.98
6.15
umol/l
0.08
481
2715
1813
14415
1.51
31.80
5.2
5.3
9.61
9.50
umol/l
0.19
1711
13614
1351
10231
1.50
29.24
3.4
2.9
33.72
29.38
u/l
2.41
1292
9788
198
850
2.40
28.04
1.4
1.2
72.00
182.76
titre
0.85
15
76
2531
22191
1.45
22.80
7.5
6.7
79.03
72.29
u/l
13.74
2396
21019
3531
33500
2.19
22.34
11.2
8.6
31.29
23.63
u/l
39.24
3460
32573
305
1727
1.83
20.60
1.8
1.8
1.47
1.36
g/l
0.30
279
1597
371
2275
1.70
19.00
2.5
2.6
10.39
10.36
g/l
0.06
338
2089
328
2124
1.60
13.46
2.3
2.1
0.22
0.22
g/l
0.33
303
2006
1613
13834
1.29
12.86
8.4
7.8
0.00
0.00
e9/l
1.14
1335
11444
2453
22241
1.31
12.64
3.2
2.7
39.68
34.35
u/l
3.33
2320
21229
910
7265
1.33
12.09
1.5
1.4
2.08
2.13
g/l
0.48
569
4616
1112
9135
1.31
12.06
2.4
2.4
59.03
56.73
u/l
0.29
1042
8513
1652
14322
1.28
11.71
6.6
5.7
8.01
7.87
%
1.10
1580
13460
1643
14240
1.28
11.65
6.4
5.4
2.84
2.81
%
0.26
1569
13335
1583
13681
1.27
11.41
6.5
5.5
0.72
0.69
%
2.08
1510
12749
853
6805
1.33
11.27
3.9
3.1
99.56
98.64
%
0.58
825
6580
1294
10942
1.28
11.02
4.5
4.2
36.39
36.63
g/l
0.92
1207
10281
1700
14880
1.26
10.82
6.3
5.4
29.87
29.80
%
0.12
1625
14028
1731
15223
1.26
10.44
6.2
5.4
0.52
0.52
e9/l
0.44
1544
13466
341
2362
1.49
10.28
3.1
4.2
243.22
233.95
u/l
0.16
324
2234
1674
14685
1.26
10.25
6.2
5.3
56.07
56.24
%
0.28
1607
13818
107
543
2.00
10.16
1.9
1.4
9.03
6.32
iu/ml
—
6
9
1209
10222
1.27
10.08
6.5
7.5
1.06
1.07
inr
0.62
425
3407
56
228
2.48
9.11
1.1
1.1
315.49
290.72
mg/l
0.89
45
205
49
192
2.57
8.64
1.3
1.3
272.86
178.94
titre
0.33
14
47
1767
15781
1.23
8.60
6.3
5.3
1.93
1.97
e9/l
0.78
1619
14319
1773
15871
1.22
8.34
6.4
5.4
0.18
0.18
e9/l
0.04
1613
14251
510
3955
1.34
7.96
2.1
2.1
14.40
14.52
umol/l
0.15
474
3713
48
195
2.48
7.89
1.1
1.1
—
—
—
0
0
74
362
2.07
7.85
1.1
1.1
1.41
1.45
g/l
0.36
63
325
1947
17679
1.21
7.67
3.2
2.9
64.06
70.73
ug/l
2.44
1852
16765
415
3140
1.36
7.61
2.2
2.2
23.36
23.92
%
0.35
358
2712
352
2593
1.40
7.61
2.4
2.2
35.18
35.62
u/l
0.04
317
2216
951
8039
1.25
7.51
3.0
2.7
33.69
71.41
e6/l
1.24
697
6022
2499
23318
1.22
7.24
4.4
3.8
10.21
9.79
mm/h
1.09
2363
22013
1484
13178
1.21
7.20
2.4
2.2
76.65
76.06
nmol/l
0.37
1378
12303
846
7105
1.25
7.02
2.3
2.1
2.56
2.70
mg/l
1.25
747
6157
133
822
1.64
6.71
2.1
2.0
1.18
1.34
g/l
1.28
115
714
1031
8890
1.22
6.62
1.3
1.3
1.04
1.54
u/ml
1.85
298
2671
452
3539
1.32
6.56
2.2
2.1
2.48
2.48
g/l
0.07
415
3276
1144
10004
1.21
6.31
1.8
1.7
102.32
99.93
pmol/l
0.87
584
5297
861
7330
1.23
6.20
3.0
2.6
0.20
0.30
e6/l
1.60
634
5440
183
1241
1.50
6.19
1.4
1.3
—
—
—
0
0
111
670
1.68
6.16
4.3
3.5
788.06
388.43
u/ml
0.31
96
571
1913
17555
1.19
6.08
8.3
7.9
3.84
3.89
e9/l
0.60
1699
15490
3037
29099
1.24
5.95
9.9
8.8
90.71
90.50
ml/min/173m2
0.24
2548
23866
3200
30850
1.28
5.92
5.3
5.1
1.69
1.88
mu/l
1.39
3031
29258
3015
28871
1.24
5.91
13.8
12.1
15.70
14.54
%
0.41
2981
28425
2852
27154
1.22
5.90
4.0
3.8
—
—
—
0
0
76
417
1.84
5.88
1.3
1.3
—
—
—
0
0
49
235
2.10
5.58
1.0
1.1
—
—
—
0
0
780
6641
1.22
5.55
1.3
1.3
10.21
9.62
u/ml
0.11
296
2868
119
757
1.59
5.41
2.4
1.6
531.43
477.78
titre
—
7
36
1382
12435
1.18
5.31
5.4
5.3
1.22
1.22
mmol/l
1.37
1184
10591
35
150
2.35
5.23
2.9
2.9
8.55
7.67
mg/l
0.30
28
109
482
3938
1.26
5.00
2.6
2.4
4.84
4.70
e6/l
0.06
245
2047
799
6903
1.20
4.82
1.3
1.3
25.88
26.92
iu/ml
0.09
253
2305
2863
27442
1.19
4.67
4.7
4.5
14.38
14.35
pmol/l
0.23
2674
25903
1228
11032
1.17
4.66
5.0
4.6
1.22
1.22
mmol/l
1.54
1155
10165
580
4875
1.23
4.63
3.0
2.3
105.43
100.72
ug/g
0.15
463
3826
1153
10313
1.17
4.62
3.6
3.2
71.29
74.11
e6/l
0.06
761
6669
795
6921
1.19
4.37
2.2
2.1
604.49
2731.00
umol/l
5.44
710
6254
622
5310
1.21
4.23
1.4
1.4
21.84
21.57
nmol/l
0.18
538
4662
657
5678
1.19
3.90
2.5
2.2
9.12
8.32
e6/l
0.22
579
5029
413
3414
1.24
3.87
2.4
2.0
29.01
28.92
s
0.11
395
3290
319
2582
1.26
3.62
1.3
1.3
193.85
148.42
u/ml
0.27
300
2399
32
158
2.03
3.50
1.9
1.5
2.29
5.72
u/l
2.72
24
132
3195
31112
1.20
3.48
10.9
10.0
3.89
3.90
mmol/l
1.10
3119
30249
136
981
1.40
3.47
2.5
2.2
3.92
3.62
g/l
1.48
124
920
3185
31018
1.19
3.40
10.8
9.9
139.66
139.63
mmol/l
0.43
3111
30245
237
2980
0.78
3.35
5.1
4.9
—
—
—
0
0
46
261
1.77
3.34
1.0
1.1
8.09
10.63
iu/ml
0.28
12
68
832
7417
1.16
3.33
1.9
1.7
1.03
0.90
mg/l
0.69
614
5540
498
4261
1.19
3.30
2.5
2.3
2.22
1.07
e6/l
0.59
260
2358
49
286
1.72
3.24
1.1
1.2
—
—
—
0
0
818
7297
1.16
3.24
1.9
1.9
133.19
138.27
u/l
0.12
782
6927
38
206
1.85
3.21
1.4
1.5
—
—
—
0
0
162
1222
1.34
3.16
1.9
2.0
40.13
38.93
u/l
0.34
149
1130
432
3668
1.20
3.12
3.1
3.1
0.83
0.82
mmol/l
0.62
408
3471
153
1149
1.35
3.08
1.4
1.4
—
—
—
0
0
246
1972
1.27
3.06
2.0
2.6
1.63
1.72
%
0.85
214
1774
2370
22663
1.13
3.05
4.5
4.0
612.72
1532.35
e6/l
0.79
25
243
2744
26486
1.14
3.02
4.5
4.2
37.41
37.50
mmol/mol
0.23
2590
25022
70
461
1.53
2.90
3.4
5.1
123.71
395.41
iu/ml
—
7
54
45
267
1.69
2.85
1.2
1.1
—
—
—
0
0
1772
16712
1.12
2.80
4.2
3.8
6.19
6.24
mmol/l
0.57
1596
14851
358
3021
1.20
2.78
1.9
2.1
379.07
368.95
nmol/l
0.46
336
2801
1060
9721
1.13
2.72
1.7
1.7
—
—
—
0
0
61
400
1.53
2.61
2.0
1.7
36.00
23.37
iu/ml
—
5
19
31
170
1.83
2.58
1.2
1.3
—
—
—
0
0
331
2794
1.20
2.58
2.8
3.4
4.56
4.55
pmol/l
0.10
304
2528
48
299
1.61
2.56
1.2
1.1
—
55.04
—
0
5
204
1646
1.25
2.46
1.2
1.3
0.29
1.06
u/ml
2.21
16
137
523
4610
1.16
2.43
2.5
2.5
663.88
564.11
ng/l
0.23
423
3764
168
1327
1.28
2.42
1.7
1.8
—
—
—
0
0
977
8982
1.12
2.36
2.9
3.1
2.35
2.35
mmol/l
0.25
865
8148
185
1484
1.26
2.36
7.5
6.7
7.75
7.16
mmol/l
0.67
176
1437
3024
29513
1.13
2.33
3.7
3.6
5.58
5.59
mmol/l
0.14
2827
27719
88
637
1.39
2.31
1.2
1.1
12.11
11.61
au/ml
0.03
12
36
435
3797
1.17
2.31
1.6
1.6
1.33
1.32
%
0.14
382
3389
812
7397
1.13
2.30
1.6
1.6
1.25
1.33
mmol/l
1.73
711
6392
187
1517
1.25
2.18
2.2
2.6
66.88
67.12
g/l
0.19
173
1404
88
647
1.37
2.13
3.6
3.6
57.15
56.98
%
0.05
88
647
79
571
1.39
2.12
2.9
2.3
0.40
0.54
g/l
0.25
74
513
71
504
1.42
2.11
1.8
1.6
16640.50
6794.97
e6/l
0.78
52
372
3291
32348
1.16
2.09
11.8
10.3
17.05
18.41
mg/l
1.88
2573
25172
76
548
1.39
2.07
1.5
1.4
—
—
—
0
0
685
6220
1.12
2.04
4.2
3.6
10.19
9.81
mg/mmol
0.08
421
3788
300
2578
1.18
1.96
2.3
2.3
17.23
23.20
au/ml
0.72
15
256
131
1034
1.28
1.96
1.2
1.2
—
—
—
0
0
289
2477
1.18
1.95
2.4
2.6
—
—
—
0
0
427
3778
1.15
1.91
1.7
1.6
1124.29
1190.73
nmol/l
0.90
343
3016
150
1209
1.25
1.89
1.9
1.9
—
—
—
0
0
768
7053
1.11
1.87
3.7
3.0
7.29
7.29
mmol/l
0.01
676
6193
129
1023
1.27
1.87
1.3
1.3
6.34
7.89
u/ml
0.18
16
176
119
935
1.28
1.86
1.3
1.3
72.23
39.46
u/ml
—
9
98
11
46
2.40
1.85
1.2
1.2
—
—
—
0
0
276
2370
1.18
1.84
1.3
1.3
23.13
42.62
au/ml
—
6
124
60
426
1.42
1.82
1.2
1.2
—
—
—
0
0
60
426
1.42
1.82
1.2
1.2
—
—
—
0
0
58
413
1.41
1.75
2.0
1.3
—
215.00
—
0
8
653
5969
1.11
1.74
3.6
3.1
373.46
539.15
mg/l
0.40
406
3619
126
1007
1.26
1.74
1.3
1.3
6.51
5.64
u/ml
0.08
11
99
5
13
3.85
1.71
1.0
1.0
—
—
—
0
0
88
673
1.32
1.71
2.2
2.3
—
—
—
0
0
410
3652
1.14
1.68
2.7
2.3
6781.95
6976.58
u/l
0.04
183
1708
21
119
1.77
1.66
1.0
1.1
—
—
—
0
0
44
301
1.47
1.65
1.3
1.2
—
—
—
0
0
353
3121
1.14
1.63
3.6
3.6
33.40
32.98
%
0.32
263
2361
44
302
1.46
1.63
1.3
1.2
—
—
—
0
0
208
2435
0.85
1.58
1.4
1.5
—
—
—
0
0
6
20
3.00
1.58
1.0
1.2
—
—
—
0
0
142
1165
1.23
1.58
1.8
2.1
3.19
4.26
iu/l
1.85
50
474
14
261
0.53
1.57
1.4
1.5
—
—
—
0
0
14
261
0.53
1.57
1.4
1.5
—
—
—
0
0
158
1313
1.21
1.55
2.3
2.5
71.74
100.20
ng/l
1.93
138
1185
138
1132
1.23
1.54
1.4
1.5
—
—
—
0
0
44
306
1.44
1.54
1.3
1.2
—
—
—
0
0
44
306
1.44
1.54
1.3
1.2
—
—
—
0
0
44
306
1.44
1.54
1.3
1.2
—
—
—
0
0
36
242
1.49
1.49
2.0
1.3
—
—
—
0
0
15
79
1.90
1.49
1.4
7.0
11863.60
64.16
mg/l
—
10
56
91
715
1.28
1.48
1.2
1.3
—
—
—
0
0
54
393
1.38
1.48
2.3
2.5
14.83
104.41
ug/min
3.47
37
243
9
37
2.44
1.47
1.0
1.2
—
—
—
0
0
130
1577
0.82
1.47
2.1
2.1
—
—
—
0
0
131
1077
1.22
1.45
2.3
2.0
0.23
0.23
g/l
0.16
126
1018
604
5558
1.10
1.43
1.6
1.5
14953704.90
35136128.92
pmol/l
0.64
535
4827
22
133
1.66
1.42
1.1
1.1
—
—
—
0
0
114
927
1.24
1.40
1.6
1.5
—
—
—
0
0
18
103
1.75
1.40
31.3
23.7
111.50
112.98
ug/l
0.03
18
83
95
757
1.26
1.40
2.0
2.1
10.21
10.12
mg/l
0.04
89
716
368
3300
1.13
1.39
1.7
1.5
—
—
—
0
0
306
2715
1.14
1.37
5.1
4.6
1.05
1.04
mmol/l
0.46
286
2543
164
1387
1.19
1.37
2.1
2.7
65.11
72.14
e9/l
2.20
116
1027
108
1323
0.81
1.36
1.3
1.2
11.85
11.84
u/l
0.00
90
1129
137
1143
1.21
1.33
1.3
1.3
85.86
31.18
u/ml
—
5
85
22
136
1.62
1.32
1.3
1.7
—
—
—
0
0
396
3582
1.12
1.31
1.3
1.2
179.61
156.99
iu/ml
0.46
157
1474
841
7890
1.09
1.31
2.0
1.9
—
—
—
0
0
49
360
1.37
1.30
1.2
1.5
—
2933.33
—
0
6
198
1711
1.17
1.29
1.5
1.6
—
—
—
0
0
26
169
1.54
1.28
1.2
1.1
96.27
98.51
%
0.22
11
67
126
1052
1.20
1.23
1.5
1.6
0.05
17.38
iu/ml
0.51
21
194
103
1252
0.82
1.23
1.3
1.3
3.02
3.96
ug/l
1.49
95
1162
22
139
1.59
1.23
1.1
1.4
—
—
u/ml
—
0
0
10
189
0.53
1.22
1.9
2.4
—
—
—
0
0
38
271
1.41
1.21
1.3
1.3
—
—
—
0
0
936
8847
1.08
1.20
2.6
2.6
25.63
29.04
ng/l
0.17
392
3980
3099
30536
1.09
1.20
3.8
3.6
4.80
4.88
mmol/l
4.78
2963
29089
247
2184
1.14
1.20
1.9
1.8
—
—
—
0
0
13
72
1.81
1.15
1.1
1.1
—
—
—
0
0
466
4286
1.10
1.14
3.0
2.8
282.71
282.81
ng/l
0.00
257
2308
37
268
1.38
1.10
1.7
1.7
53.33
50.88
%
0.12
24
158
95
1147
0.82
1.09
5.7
7.0
24.76
24.44
mmol/l
0.42
87
1091
72
576
1.25
1.08
1.2
1.1
—
—
—
0
0
1745
16907
1.06
1.04
3.6
3.3
0.00
0.00
estimate
1.54
431
3615
234
2090
1.13
1.01
3.2
3.2
1.23
1.23
mmol/l
0.82
214
1821
31
222
1.40
1.00
1.1
1.3
1.56
1.60
g/l
0.42
31
222
24
164
1.47
0.99
1.2
1.2
—
—
—
0
0
3627
36108
1.23
0.98
17.8
15.5
266.11
266.20
e9/l
0.03
3570
35484
0
29
0.00
0.97
0.0
1.1
—
17.90
—
0
10
2959
29165
1.07
0.97
3.4
3.2
1.12
1.19
mmol/l
9.42
2819
27616
24
165
1.46
0.96
1.2
1.1
101.36
102.38
%
0.07
11
66
44
570
0.77
0.96
1.4
1.4
33.85
31.05
nmol/l
0.24
37
516
3121
30829
1.08
0.95
4.0
3.9
2.87
2.93
mmol/l
3.14
2962
29213
194
1721
1.13
0.94
3.4
3.0
72.75
71.78
ng/l
0.07
172
1531
94
788
1.20
0.94
1.1
1.1
0.89
1.72
u/ml
0.82
44
365
14
85
1.65
0.94
1.1
1.1
—
—
—
0
0
70
571
1.23
0.92
2.8
2.0
153.65
256.11
ug/l
0.79
59
506
112
957
1.18
0.91
1.2
1.1
2.23
2.16
u/ml
0.03
58
449
3621
36054
1.21
0.89
17.8
15.4
39.52
39.84
%
0.94
3486
34398
689
7277
0.93
0.88
3.7
3.6
1.02
1.02
kg/l
0.20
120
1169
29
211
1.38
0.88
1.2
1.1
—
—
—
0
0
40
517
0.77
0.88
1.1
1.1
2.13
19411.26
iu/ml
—
8
138
41
528
0.77
0.88
1.5
1.6
—
—
—
0
0
1759
17109
1.05
0.87
3.6
3.3
0.00
0.00
estimate
1.57
427
3482
1747
16990
1.05
0.87
5.0
4.5
0.00
0.00
estimate
0.80
422
3511
73
605
1.21
0.84
1.4
1.2
2.29
4.61
u/ml
2.52
28
229
13
80
1.63
0.84
1.6
1.6
—
—
iu/ml
—
0
0
97
826
1.18
0.84
1.7
1.5
6.44
6.63
mmol/l
0.38
83
755
186
1661
1.13
0.84
1.8
1.6
3.04
4.04
mg/l
1.23
144
1172
29
389
0.74
0.84
1.5
1.5
—
—
—
0
0
29
389
0.74
0.84
1.5
1.5
—
—
—
0
0
3627
36127
1.20
0.82
17.8
15.5
6.63
6.70
e9/l
1.03
3566
35428
11
65
1.69
0.82
1.3
1.1
—
—
—
0
0
6
32
1.88
0.81
1.2
1.1
—
—
—
0
0
143
1259
1.14
0.81
3.0
2.6
4.76
4.60
kpa
0.32
137
1216
3075
30400
1.07
0.80
3.7
3.6
1.57
1.56
mmol/l
0.11
2933
28898
413
3849
1.08
0.80
1.6
1.5
—
—
—
0
0
21
147
1.43
0.80
1.3
1.3
144.42
139.95
mmol/24h
0.11
21
147
329
3038
1.09
0.79
1.9
1.8
—
—
—
0
0
30
395
0.76
0.78
1.6
1.4
—
—
—
0
0
5
98
0.51
0.77
4.4
2.6
—
—
—
0
0
3627
36135
1.19
0.76
17.7
15.5
4.44
4.44
e12/l
0.01
3566
35471
5
24
2.08
0.74
1.2
1.0
8.16
8.15
mmol/l
—
5
24
142
1261
1.13
0.73
2.5
2.3
0.30
0.22
e6/l
0.36
135
1197
5
25
2.00
0.72
1.2
1.1
—
—
—
0
0
89
765
1.17
0.72
1.4
1.3
320.89
311.37
ug/g
0.17
44
392
9
57
1.58
0.71
1.0
1.3
—
—
—
0
0
243
2229
1.10
0.70
1.1
1.0
—
—
—
0
0
124
1095
1.14
0.70
3.4
2.7
1.81
1.53
mmol/l
0.41
80
802
5
27
1.85
0.68
1.4
1.1
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
30
231
1.30
0.67
1.9
1.7
125.97
124.47
%
0.04
30
217
3627
36147
1.17
0.67
17.9
15.6
132.08
132.78
g/l
3.68
3603
35853
27
205
1.32
0.67
1.9
1.5
48.22
40.89
%
0.41
19
119
19
136
1.40
0.66
1.3
1.2
—
—
—
0
0
36
285
1.27
0.66
1.2
1.2
—
—
—
0
0
200
2190
0.91
0.66
2.3
2.2
73.08
75.81
ml/min/173m2
0.51
73
787
389
3652
1.07
0.65
1.7
1.7
—
—
—
0
0
31
393
0.79
0.64
1.1
1.1
—
—
—
0
0
74
635
1.17
0.63
1.3
1.2
1.28
2.65
u/ml
2.09
25
208
36
288
1.25
0.62
1.2
1.2
—
—
—
0
0
48
397
1.21
0.61
1.1
1.1
95.81
93.76
%
0.23
48
368
126
1126
1.12
0.61
1.5
1.5
—
—
—
0
0
44
532
0.82
0.60
1.5
1.6
—
—
—
0
0
22
165
1.34
0.60
1.3
1.6
0.77
3.03
u/field
2.08
13
115
77
668
1.16
0.59
1.1
1.1
0.99
4.72
u/ml
6.31
32
266
43
354
1.22
0.58
1.8
1.6
—
—
—
0
0
23
299
0.77
0.58
1.6
1.4
—
—
—
0
0
706
6781
1.05
0.57
1.6
1.5
—
—
—
0
0
57
485
1.18
0.56
2.5
2.4
—
—
—
0
0
206
2230
0.92
0.56
1.5
1.4
—
—
—
0
0
170
1555
1.10
0.56
3.7
3.0
5.78
5.81
kpa
0.16
165
1504
122
1097
1.12
0.55
2.2
2.0
—
—
—
0
0
32
257
1.25
0.55
1.2
1.2
—
—
—
0
0
793
7647
1.05
0.55
2.1
2.0
—
—
—
0
0
6
38
1.58
0.54
1.2
1.1
—
—
—
0
0
34
276
1.23
0.54
1.1
1.2
0.60
1.40
u/ml
0.54
15
131
28
222
1.26
0.53
2.6
2.8
—
—
—
0
0
11
74
1.49
0.53
5.1
4.6
—
—
—
0
0
6
39
1.54
0.53
1.2
1.1
—
—
—
0
0
66
572
1.16
0.53
1.2
1.3
—
—
—
0
0
21
271
0.77
0.52
1.4
1.5
—
—
—
0
0
134
1217
1.10
0.52
1.1
1.1
7.40
6.40
u/ml
0.05
20
186
371
3514
1.06
0.51
1.3
1.3
27.95
27.55
iu/l
0.08
331
3082
110
990
1.11
0.51
2.1
1.9
—
—
—
0
0
19
247
0.77
0.50
1.4
2.0
—
—
—
0
0
707
6821
1.05
0.49
2.0
2.0
—
—
—
0
0
111
1003
1.11
0.48
1.8
1.6
7.59
7.57
mmol/l
0.05
103
966
30
366
0.82
0.48
1.2
1.6
—
—
—
0
0
126
1148
1.10
0.47
3.7
2.8
5.12
5.11
kpa
0.04
117
1102
36
300
1.20
0.46
1.9
1.9
19.31
26.66
mg/l
—
9
81
77
683
1.13
0.46
1.4
1.6
—
—
—
0
0
167
1544
1.09
0.46
3.7
3.0
1.53
1.82
mmol/l
0.44
137
1326
159
1719
0.92
0.45
11.0
7.1
119.01
121.16
g/l
0.77
152
1672
41
348
1.18
0.44
1.0
1.1
189.59
204.27
mg/l
0.53
35
308
95
857
1.11
0.44
1.1
1.1
3.00
5.64
u/ml
1.43
44
436
72
809
0.89
0.43
1.2
1.2
—
—
—
0
0
26
211
1.23
0.43
1.3
1.4
71.19
67.88
umol/l
0.45
26
211
30
361
0.83
0.43
1.6
1.7
—
—
—
0
0
11
78
1.41
0.43
2.2
3.1
—
—
—
0
0
65
574
1.13
0.43
1.1
1.2
—
—
—
0
0
453
4342
1.05
0.43
2.4
2.5
2.43
2.42
mmol/l
0.83
388
3795
157
1455
1.08
0.42
1.6
1.5
—
—
—
0
0
21
262
0.80
0.42
1.1
1.1
—
—
—
0
0
5
32
1.56
0.42
1.2
2.2
0.60
0.91
u/field
—
5
32
235
2213
1.07
0.41
4.3
3.7
59.63
34.56
ug/l
0.24
179
1643
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
78
700
1.12
0.40
1.1
1.1
—
—
—
0
0
89
805
1.11
0.40
1.1
1.1
0.79
1.27
u/ml
0.45
33
309
5
34
1.47
0.40
1.0
1.0
—
—
—
0
0
82
739
1.11
0.40
3.3
5.1
1.75
1.72
%
0.06
75
687
19
238
0.80
0.40
1.5
1.6
—
—
—
0
0
28
336
0.83
0.40
1.6
1.5
—
—
—
0
0
8
61
1.31
0.39
1.8
1.6
13.59
59.38
u/l
—
8
55
372
3562
1.05
0.38
1.5
1.4
—
—
—
0
0
474
4565
1.04
0.38
1.5
1.4
—
—
—
0
0
14
107
1.31
0.37
1.1
1.0
—
—
—
0
0
9
69
1.31
0.37
1.0
1.5
—
—
—
0
0
9
69
1.31
0.37
1.0
1.5
—
—
—
0
0
9
70
1.29
0.36
1.1
1.4
—
—
—
0
0
373
3577
1.05
0.36
1.5
1.4
—
—
—
0
0
49
431
1.14
0.36
1.9
1.7
—
—
—
0
0
234
2217
1.06
0.36
1.7
1.5
397.41
285.59
mu/l
0.40
205
1958
12
90
1.33
0.35
1.1
1.2
95.00
96.36
%
0.06
12
90
12
90
1.33
0.35
2.4
2.4
—
—
—
0
0
79
717
1.10
0.35
1.1
1.1
1.23
4.80
u/ml
2.49
36
326
57
509
1.12
0.34
1.7
2.1
130.98
129.24
g/l
0.29
45
389
373
3585
1.04
0.34
1.5
1.4
—
—
—
0
0
43
377
1.14
0.34
1.3
1.4
—
—
—
0
0
17
136
1.25
0.33
1.3
1.5
120.94
124.44
nmol/l
0.16
17
136
241
2292
1.06
0.33
1.5
1.5
—
—
—
0
0
42
368
1.14
0.33
1.3
1.4
—
—
—
0
0
163
1733
0.94
0.33
1.2
1.2
—
—
—
0
0
211
2000
1.06
0.33
1.4
1.3
229.22
234.53
miu/ml
0.08
106
1017
6
47
1.28
0.32
1.0
1.0
—
—
—
0
0
41
360
1.14
0.32
1.1
1.2
41.87
35.88
mg/l
0.21
31
301
12
92
1.31
0.31
1.0
1.3
—
—
—
0
0
22
183
1.20
0.31
1.1
1.1
—
—
—
0
0
42
370
1.14
0.31
1.3
1.4
—
—
—
0
0
372
3583
1.04
0.31
1.5
1.4
—
—
—
0
0
54
484
1.12
0.31
1.4
1.3
1.11
1.28
nmol/l
0.55
42
423
23
273
0.84
0.31
1.4
1.5
—
—
—
0
0
42
371
1.13
0.30
1.3
1.4
—
—
—
0
0
271
2594
1.05
0.30
1.5
1.5
—
—
—
0
0
18
218
0.82
0.30
1.5
1.6
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
50
448
1.12
0.29
3.5
3.8
0.39
0.36
u/ml
0.26
27
255
48
429
1.12
0.29
2.3
2.1
—
—
—
0
0
128
1364
0.94
0.29
2.1
2.0
11.98
4.84
ug/l
1.23
112
1208
8
107
0.75
0.29
1.0
1.0
—
—
—
0
0
8
107
0.75
0.29
2.0
1.5
—
—
—
0
0
25
213
1.17
0.29
1.6
1.8
0.70
2.09
u/field
—
10
106
43
383
1.12
0.28
1.3
1.4
—
—
—
0
0
8
62
1.29
0.28
1.1
1.2
—
—
—
0
0
393
3804
1.04
0.27
1.6
1.5
—
—
—
0
0
8
64
1.25
0.27
1.1
1.1
—
—
—
0
0
9
117
0.77
0.27
3.3
2.1
1.92
1.14
ug/l
—
9
112
42
375
1.12
0.27
1.3
1.4
—
—
—
0
0
8
66
1.21
0.26
1.1
1.5
—
—
—
0
0
10
77
1.30
0.26
1.5
3.3
—
—
—
0
0
16
132
1.21
0.25
1.1
1.3
68.45
88.27
nmol/24h
0.84
16
132
13
105
1.24
0.24
1.0
5.3
—
59.85
—
0
13
42
378
1.11
0.24
1.2
1.1
—
—
—
0
0
38
340
1.12
0.24
1.1
1.1
—
—
—
0
0
927
9110
1.02
0.24
3.6
3.6
0.01
0.00
estimate
0.50
424
3477
63
580
1.09
0.24
1.1
1.1
0.04
0.33
u/ml
0.68
16
145
26
296
0.88
0.23
5.4
5.0
376.42
371.67
umol/l
0.05
19
249
11
136
0.81
0.23
1.2
1.1
—
—
—
0
0
30
337
0.89
0.22
1.6
1.4
—
—
—
0
0
10
79
1.27
0.22
1.3
1.3
8.00
11.77
u/l
—
10
73
0
11
0.00
0.21
0.0
1.4
—
26.23
—
0
11
23
262
0.88
0.21
1.1
1.1
1702.70
1502.19
miu/ml
0.44
23
262
8
104
0.77
0.21
2.0
1.5
—
—
—
0
0
267
2584
1.04
0.21
3.1
2.8
34.32
40.21
u/ml
0.26
257
2497
0
13
0.00
0.21
0.0
1.0
—
0.11
—
0
5
0
13
0.00
0.21
0.0
1.0
—
0.07
—
0
5
45
412
1.09
0.20
1.9
2.1
16.94
16.66
%
0.16
20
202
48
441
1.09
0.20
3.8
3.9
31.85
45.11
mg/l
0.68
38
365
12
143
0.84
0.18
2.3
1.4
1552.29
3358.25
e6/l
—
7
102
15
128
1.17
0.18
1.6
1.7
—
—
—
0
0
15
128
1.17
0.18
1.6
1.7
—
—
—
0
0
12
100
1.20
0.18
1.2
1.3
—
—
—
0
0
12
100
1.20
0.18
1.2
1.3
—
—
—
0
0
17
147
1.16
0.18
1.2
1.5
12.44
14.01
pmol/l
0.95
17
118
7
60
1.17
0.17
1.1
1.1
—
—
—
0
0
7
61
1.15
0.17
1.1
1.1
—
—
—
0
0
10
82
1.22
0.17
1.1
1.0
64.74
74.05
ug/l
—
10
74
23
257
0.89
0.17
4.5
4.9
6.84
6.60
mmol/l
0.11
16
211
15
173
0.87
0.16
1.2
1.3
—
—
—
0
0
64
603
1.06
0.16
1.1
1.1
—
—
—
0
0
8
72
1.11
0.16
1.1
1.0
—
—
—
0
0
17
193
0.88
0.15
1.5
1.6
—
—
—
0
0
17
193
0.88
0.15
1.5
1.6
—
—
—
0
0
17
193
0.88
0.15
1.5
1.6
—
—
—
0
0
9
79
1.14
0.15
1.0
1.0
—
—
—
0
0
9
79
1.14
0.15
1.0
1.1
—
—
—
0
0
67
634
1.06
0.15
2.7
2.0
1.05
1.78
ug/l
0.52
59
570
7
87
0.80
0.14
1.1
1.3
—
—
—
0
0
30
275
1.09
0.14
1.2
1.6
—
—
—
0
0
14
160
0.87
0.14
1.1
1.0
—
—
—
0
0
47
441
1.07
0.13
3.9
3.9
22.46
43.30
mg/l
0.95
38
365
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
15
170
0.88
0.13
1.3
1.1
—
—
—
0
0
11
128
0.86
0.13
1.1
1.2
—
—
—
0
0
198
2032
0.97
0.13
9.7
6.6
0.68
0.88
mmol/l
0.29
158
1587
14
158
0.89
0.12
1.3
1.5
—
—
—
0
0
80
767
1.04
0.12
1.1
1.2
3.60
3.61
mmol/l
0.01
74
720
10
116
0.86
0.12
1.8
1.5
—
—
—
0
0
18
162
1.11
0.11
1.2
1.1
—
—
—
0
0
11
126
0.87
0.11
2.5
1.4
4733.00
66579.70
e6/l
—
5
71
1713
17040
1.01
0.10
2.6
2.4
—
—
—
0
0
113
1096
1.03
0.10
1.4
1.4
27.05
24.11
u/l
0.41
90
912
16
144
1.11
0.10
3.3
3.4
—
—
—
0
0
23
249
0.92
0.10
1.0
1.1
1.00
1.02
u/l
0.15
11
102
89
860
1.04
0.10
1.1
1.3
439.79
468.34
mg/l
0.27
82
820
69
663
1.04
0.10
1.1
1.1
1.67
3.89
u/ml
2.24
37
341
5
45
1.11
0.09
1.0
1.4
—
—
—
0
0
5
47
1.06
0.09
1.0
1.1
—
—
—
0
0
59
615
0.96
0.09
3.4
3.3
30.72
21.27
mg/l
0.90
36
367
16
145
1.10
0.09
1.1
1.1
17.07
9.59
u/ml
—
9
95
1329
13217
1.01
0.08
3.6
3.3
—
—
—
0
0
27
253
1.07
0.08
1.6
1.4
—
—
—
0
0
23
214
1.08
0.08
1.7
2.5
31.30
32.07
pg
0.27
23
214
5
60
0.83
0.08
1.2
1.7
—
—
—
0
0
25
234
1.07
0.08
1.1
1.1
—
—
—
0
0
1084
10777
1.01
0.07
1.5
1.5
—
—
—
0
0
6
70
0.86
0.07
1.2
1.3
—
—
—
0
0
6
74
0.81
0.07
1.3
2.6
18.08
15.03
umol/l
—
6
74
8
76
1.05
0.07
1.1
1.1
—
—
—
0
0
8
76
1.05
0.07
1.1
1.1
—
—
—
0
0
14
153
0.91
0.07
2.2
1.4
37.14
35.39
g/l
0.22
14
140
41
428
0.96
0.07
1.1
1.2
—
—
—
0
0
9
84
1.07
0.07
1.0
1.1
—
—
—
0
0
9
86
1.05
0.07
1.2
1.5
8.34
8.07
ug/l
—
9
86
74
719
1.03
0.07
4.2
2.7
25.06
24.80
mmol/l
0.35
65
668
11
99
1.11
0.06
1.0
1.1
—
—
—
0
0
11
99
1.11
0.06
1.7
1.9
—
—
—
0
0
11
99
1.11
0.06
1.7
1.9
—
—
—
0
0
11
99
1.11
0.06
1.7
1.9
—
—
—
0
0
77
751
1.03
0.06
1.2
1.4
992.72
1942.19
e6/l
0.35
61
616
177
1793
0.99
0.05
10.3
6.9
95.88
96.42
%
0.42
169
1732
13
120
1.08
0.04
1.2
1.2
—
—
—
0
0
235
2327
1.01
0.04
1.4
1.5
—
—
—
0
0
46
447
1.03
0.04
2.4
2.2
0.82
0.82
nmol/l
0.01
37
387
58
594
0.98
0.04
1.1
1.2
—
—
—
0
0
20
190
1.05
0.04
2.0
1.3
4818.21
85133.98
e6/l
1.10
14
126
10
92
1.09
0.03
1.1
1.9
—
—
—
0
0
32
310
1.03
0.03
1.1
1.1
1.08
1.04
ratio
0.43
14
116
381
3828
0.99
0.02
1.5
1.6
—
—
—
0
0
238
2365
1.01
0.02
1.4
1.6
—
—
—
0
0
29
282
1.03
0.02
1.8
1.9
—
—
—
0
0
93
940
0.99
0.02
1.2
1.1
—
—
—
0
0
76
751
1.01
0.01
1.2
1.3
3.31
26.04
e6/l
3.56
55
573
78
771
1.01
0.01
1.8
1.9
—
—
—
0
0
43
422
1.02
0.01
3.2
4.3
34.23
88.92
u/ml
—
9
140
511
5099
1.00
0.01
1.7
1.8
—
—
—
0
0
114
1133
1.01
0.00
1.3
1.4
0.36
0.53
nmol/l
2.24
92
919
13
124
1.05
0.00
1.2
1.2
—
—
—
0
0
16
154
1.04
0.00
1.6
1.5
—
—
—
0
0
202
2027
1.00
0.00
9.5
6.5
13.49
13.61
kpa
0.09
193
1945
202
2027
1.00
0.00
9.5
6.5
5.04
5.02
kpa
0.14
193
1949
24
246
0.98
0.00
1.2
1.3
—
68.00
—
0
14
13
125
1.04
0.00
2.3
1.6
—
—
—
0
0
94
945
0.99
0.00
1.2
1.1
—
—
—
0
0
21
211
1.00
0.00
1.4
1.6
1.02
1.29
promille
0.38
15
151
67
666
1.01
0.00
1.2
1.3
—
—
—
0
0
14
136
1.03
0.00
1.5
1.3
5.78
6.48
mmol/l
0.85
14
128
35
354
0.99
0.00
1.1
1.2
—
—
—
0
0
44
437
1.01
0.00
4.5
7.4
105.18
105.35
mmol/l
0.07
38
391
57
567
1.01
0.00
2.2
2.1
5.34
5.37
mmol/24h
0.03
52
503
11
113
0.97
0.00
1.0
1.1
—
—
—
0
0
5
51
0.98
0.00
1.6
1.2
79.80
84.45
ng/l
—
5
51
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
4.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
1.14
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
87.60
—
0
5
9
94
0.96
-0.00
7.4
10.3
854.78
698.06
nmol/l
—
9
89
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
2.80
—
0
5
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
60
1.00
-0.00
3.8
2.3
125.17
153.35
nmol/l
—
6
52
Mortality – FinRegistry
↥Association
Association between endpoint O15_ICP_WIDE_EXMORE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| O15_ICP_WIDE_EXMORE | 0.645 [0.51, 0.82] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.15 |
During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 13316 females with O15_ICP_WIDE_EXMORE died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have O15_ICP_WIDE_EXMORE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.056% | No data |
| 5 | 0.347% | No data |
| 10 | 0.859% | No data |
| 15 | 1.645% | No data |
| 20 | 2.956% | No data |
Relationships between endpoints
↥Index endpoint: O15_ICP_WIDE_EXMORE – Intrahepatic Cholestasis of Pregnancy (ICP) , incl. ICD-8, excluding more controls
GWS hits: 33
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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