No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly females |
293373 |
2. Check conditionsNone |
293373 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2366 |
4. Check minimum number of eventsNone |
2366 |
5. Include endpointsNone |
2366 |
6. Filter based on genotype QC (FinnGen only) |
2366 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF6
- Parent code in ICD-10
- E28
- Name in latin
- Morbus polycysticus ovariorum
Similar endpoints
↥List of similar endpoints to
Polycystic ovarian syndrome
based on the number of shared cases.
Similar with more cases:
- Ovarian dysfunction
- Disorders of other endocrine glands
- Polycystic ovarian syndrome, consortium definition
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13242 | 13242 | - |
| Only index persons | 13074 | 13074 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.38 | 0.38 | - |
| Only index persons | 0.48 | 0.48 | - |
| Median age at first event (years) | |||
| Whole population | - | 27.37 | - |
| Only index persons | - | 27.35 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2366 | 2366 | - |
| Unadjusted period prevalence (%) | 0.81 | 0.81 | - |
| Median age at first event (years) | 28.34 | 28.34 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 2035
- Matched controls
- 20350
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
2669.2
323.0
1883
95
G03DB01
ATC
dydrogesterone; oral
8.7
323.0
1087
2378
N97.0
ICD-10 Finland
Female infertility associated with anovulation
25.4
323.0
706
416
A10BA02
ATC
metformin; oral
9.5
323.0
799
1291
N91.1
ICD-10 Finland
Secondary amenorrhoea
10.9
162.3
329
354
L02BG04
ATC
letrozole; oral
6.1
122.2
367
711
E66.01
ICD-10 Finland
Obesity due to excess calories
4.8
121.9
468
1201
N97.9
ICD-10 Finland
Female infertility, unspecified
4.3
115.8
497
1417
L68.0
ICD-10 Finland
Hirsutism
20.5
113.1
172
91
2564A
ICD-9 Finland
Ovarian dysfunction, Polycystic ovaries
+∞
111.5
106
*
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.8
103.2
1186
6827
G03GA01
ATC
chorionic gonadotrophin; parenteral
4.7
92.1
351
872
LA2AE
NOMESCO Finland
Ultrasound examination of ovarian cyst
5.6
85.6
268
533
Z35.0
ICD-10 Finland
Supervision of pregnancy with history of infertility
4.8
77.6
283
665
E66.8
ICD-10 Finland
Other obesity
4.6
70.4
263
630
G03HB01
ATC
cyproterone and estrogen; systemic
2.7
70.3
612
2810
G03GB02
ATC
clomifene; oral
7.8
65.8
158
217
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.8
65.4
520
2246
25690
ICD-8 Finland
Ovarian dysfunction, Syndroma Stein-Leventhal
+∞
60.7
58
*
E66.00
ICD-10 Finland
Metabolic syndrome
6.4
54.6
151
253
G03GA06
ATC
follitropin beta; parenteral
4.7
52.7
189
430
TLW00
NOMESCO Finland
Insemination
4.7
51.8
186
424
T90
ICPC
Diabetes non-insulin dependent
3.6
50.8
255
789
LC2HE
NOMESCO Finland
Hystero-salpingography with ultrasound
3.3
50.8
282
943
N91.4
ICD-10 Finland
Secondary oligomenorrhoea
11.0
50.4
98
93
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
3.8
48.9
227
657
LAA10
NOMESCO Finland
Percutaneous or transvaginal puncture and recovery of oocyte
3.9
46.1
203
561
C03DA01
ATC
spironolactone; oral
4.5
43.1
161
381
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.9
42.5
292
1121
103
Kela drug reimbursment
Diabetes, insulin-treated
2.9
42.2
294
1137
G03GA05
ATC
follitropin alfa; parenteral
3.4
41.2
218
698
G47.3
ICD-10 Finland
Sleep apnoea
2.8
39.5
282
1105
E66.9
ICD-10 Finland
Obesity, unspecified
4.2
39.1
157
398
I10
ICD-10 Finland
Essential (primary) hypertension
2.2
38.3
447
2278
G03GA02
ATC
human menopausal gonadotrophin; parenteral
3.9
37.9
163
440
N92.6
ICD-10 Finland
Irregular menstruation, unspecified
2.6
36.9
308
1322
G03DA04
ATC
progesterone; systemic, rectal, vaginal
4.5
36.0
134
315
Z32.1
ICD-10 Finland
Pregnancy confirmed
2.0
33.5
572
3390
G03DA02
ATC
medroxyprogesterone; systemic (pregnen (4) derivatives)
3.7
32.6
151
434
G03DC02
ATC
norethisterone; oral
2.9
32.1
212
789
E22.1
ICD-10 Finland
Hyperprolactinaemia
44.1
31.9
39
9
Z31.2
ICD-10 Finland
In vitrofertilization
6.4
30.9
83
134
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
2.0
29.9
437
2424
N92.1
ICD-10 Finland
Excessive and frequent menstruation with irregular cycle
2.5
29.2
253
1100
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
5.4
27.8
86
166
T82
ICPC
Obesity
3.3
27.6
143
449
LCA06
NOMESCO Finland
Biopsy of endometrium
2.2
27.3
312
1550
TLW12
NOMESCO Finland
Insertion of frozen embryo
3.7
27.3
123
345
N91.2
ICD-10 Finland
Amenorrhoea, unspecified
6.6
27.2
71
111
H01CC01
ATC
ganirelix; parenteral
3.0
26.7
160
558
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.1
26.6
324
1656
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.7
26.4
730
4996
A10BK03
ATC
empagliflozin; oral
4.3
26.1
100
243
N91.3
ICD-10 Finland
Primary oligomenorrhoea
18.9
25.7
39
21
N98.1
ICD-10 Finland
Hyperstimulation of ovaries
7.4
25.0
60
83
E66
ICD-10 Finland
Obesity
3.1
24.1
140
477
SPAT1262
SPAT
Handing over of treatment supplies
2.3
24.1
248
1169
N97.4
ICD-10 Finland
Female infertility associated with male factors
3.2
23.9
129
417
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.2
23.1
244
1164
LA2HE
NOMESCO Finland
Repeated measurement of ovarian cyst
5.1
22.9
73
147
N91.5
ICD-10 Finland
Oligomenorrhoea, unspecified
6.3
22.5
60
97
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
1.8
22.4
434
2634
E11
ICD-10 Finland
Type 2 diabetes mellitus
3.1
22.3
129
439
H03AA01
ATC
levothyroxine sodium; systemic
1.8
22.3
453
2792
1413
FHL
Laparoscopy and other therapeutic procedure
5.8
21.8
62
109
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
21.8
849
6293
X05
ICPC
Menstruation absent/scanty
3.6
21.6
100
288
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.9
21.5
134
479
Z31.1
ICD-10 Finland
Artificial insemination
6.5
21.2
55
86
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.3
21.0
206
950
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.1
20.8
246
1232
XLA10
NOMESCO Finland
NA
2.9
20.8
129
459
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
20.8
383
2279
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
4.3
20.5
76
180
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
2.3
19.9
197
911
E28.1
ICD-10 Finland
Ovarian dysfunction: Androgen excess
+∞
19.8
19
*
E28.0
ICD-10 Finland
Ovarian dysfunction: Estrogen excess
+∞
19.8
19
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
19.7
381
2300
A10BH01
ATC
sitagliptin; oral
4.0
19.6
79
202
G03GA04
ATC
urofollitropin; parenteral
8.3
19.5
43
53
205
Kela drug reimbursment
Chronic hypertension
2.8
19.1
129
485
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.7
18.9
477
3115
N02AX02
ATC
tramadol; systemic, rectal
1.6
18.9
575
3957
N02BE01
ATC
paracetamol; systemic, rectal
1.7
18.9
1625
14366
C07AB07
ATC
bisoprolol; oral
1.7
18.9
422
2662
N06AX16
ATC
venlafaxine; oral
1.8
18.6
352
2104
B02AA02
ATC
tranexamic acid; systemic
1.8
18.5
363
2197
JAH01
NOMESCO Finland
Laparoscopy
2.5
18.5
146
600
LBF00
NOMESCO Finland
Perfusion of Fallopian tube
8.5
18.4
40
48
SPAT1263
SPAT
Sampling
1.5
18.2
932
7269
L02AE01
ATC
buserelin; implant, nasal, parenteral
4.8
18.1
60
127
A02BC02
ATC
pantoprazole; systemic
1.5
17.1
1008
8068
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
4.1
16.9
66
165
N05AH04
ATC
quetiapine; oral
1.7
16.8
401
2569
MA1AE
NOMESCO Finland
Ultrasound examination of early pregnancy (before 12. postmenstrual week)
1.6
16.4
511
3520
SPAT1310
SPAT
Counselling related to known health issue
1.5
16.3
681
5030
R03AC02
ATC
salbutamol; inhalant
1.5
16.2
1064
8667
LBF01
NOMESCO Finland
Laparoscopic perfusion of Fallopian tube
3.4
16.2
78
233
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
1.8
16.2
290
1697
E28.3
ICD-10 Finland
Primary ovarian failure
24.7
16.0
22
9
C08CA01
ATC
amlodipine; oral
2.1
15.8
198
1016
G56.0
ICD-10 Finland
Carpal tunnel syndrome
1.9
15.8
231
1257
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.6
15.8
444
2974
R51.80
ICD-10 Finland
Headache
1.7
15.7
390
2522
J02AC01
ATC
fluconazole; systemic
1.5
15.7
1004
8110
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.0
15.7
205
1070
6280A
ICD-9 Finland
Infertility, female, Associated with anovulation[STERILITAS ET INFERTILITAS ANOVULATORIA PRIM]
19.4
15.5
23
12
B01AB05
ATC
enoxaparin; parenteral
1.7
15.5
391
2538
M54.5
ICD-10 Finland
Low back pain
1.5
15.3
650
4804
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.9
15.1
220
1196
M79.6
ICD-10 Finland
Pain in limb
1.5
14.9
620
4557
WX110
NOMESCO Finland
Local anesthesy
1.5
14.7
1471
12933
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.4
14.7
1108
9197
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.7
14.6
360
2319
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.3
14.5
140
640
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
14.3
297
1817
L03
ICPC
Low back symptom/complaint
1.6
14.3
488
3416
W85
ICPC
Gestational diabetes
1.9
14.3
219
1211
N03AX12
ATC
gabapentin; oral
1.9
14.2
231
1305
N06AB04
ATC
citalopram; systemic
1.6
14.1
400
2672
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
2.9
14.1
88
317
LC2DE
NOMESCO Finland
Demanding ultrsound examination of uterus, parametrium and lower part of abdomen with speciel methods
2.1
13.6
162
813
LAA97
NOMESCO Finland
Other laparoscopic puncture of ovary
75.6
13.6
15
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.3
13.5
126
567
LCA13
NOMESCO Finland
Curettage of cervix and body of uterus
3.1
13.4
74
247
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.7
13.2
304
1915
SPAT1301
SPAT
No procedures
1.5
13.2
578
4271
N97.8
ICD-10 Finland
Female infertility of other origin
2.5
13.2
101
411
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.5
13.2
107
449
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.5
13.1
690
5296
C09AA05
ATC
ramipril; oral
2.3
13.1
126
575
TLW20
NOMESCO Finland
Medical ovulation induction
7.9
13.1
29
37
TLW10
NOMESCO Finland
Transfer of fresh embryo
2.6
12.8
92
361
C09CA01
ATC
losartan; oral
2.0
12.6
160
825
J01DB01
ATC
cefalexin; oral
1.5
12.5
1634
14853
A10BJ06
ATC
semaglutide; parenteral
4.0
12.5
49
125
N06AX21
ATC
duloxetine; oral
1.8
12.4
215
1240
WX704
NOMESCO Finland
Intubation
2.2
12.3
124
580
R5140
NOMESCO Finland
Monitoring the use of the aid
2.5
12.3
98
408
J01MA02
ATC
ciprofloxacin; systemic
1.5
12.2
516
3778
N06AB03
ATC
fluoxetine; oral
1.7
12.1
246
1491
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
12.1
888
7230
M01AE03
ATC
ketoprofen; systemic, rectal
1.5
12.1
520
3818
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.6
12.1
320
2094
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
12.0
215
1254
N83.1
ICD-10 Finland
Corpus luteum cyst
3.4
12.0
57
171
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.5
12.0
94
389
H01CA02
ATC
nafarelin; nasal
2.3
11.9
113
514
1410
FHL
Laparoscopy
3.6
11.7
51
143
G03DB02
ATC
megestrol; oral (pregnadien derivatives)
4.2
11.6
43
104
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
12.6
11.6
20
16
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
11.6
1175
10091
N03AX16
ATC
pregabalin; oral
1.6
11.5
307
2010
E23.05
ICD-10 Finland
Lack of TSH
+∞
11.5
11
*
N06AX12
ATC
bupropion; oral
1.8
11.4
189
1075
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
1.9
11.4
179
1001
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.9
11.3
164
890
8201
FHL
Ovarian preservation exploration and related procedures, eg resection, enucleation or ovariolysis
4.8
11.3
37
79
E66.0
ICD-10 Finland
Obesity due to excess calories
7.0
11.3
27
39
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.8
11.3
186
1056
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.6
11.2
301
1973
A10BJ02
ATC
liraglutide; parenteral
4.7
11.2
37
80
LCA30
NOMESCO Finland
Transfer of oocyte or embryo to uterus in assisted fertilisation
6.0
11.2
30
51
W15
ICPC
Infertility/subfertility female
3.3
11.2
55
170
LA2JE
NOMESCO Finland
Follow-up of menstrual cycle with repeated measurement of ovarian cyst
4.4
11.1
39
90
A02BC03
ATC
lansoprazole; oral
1.6
11.1
357
2448
L15
ICPC
Knee symptom/complaint
1.6
11.0
302
1990
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.4
10.9
1197
10370
SPAT1240
SPAT
Therapeutic discussion
1.6
10.7
343
2352
SGA01
NOMESCO Finland
Tooth opening as first aid
1.5
10.6
356
2463
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
60.3
10.6
12
*
SGA03
NOMESCO Finland
Demanding opening and dilatation of root canal of tooth
1.7
10.6
206
1233
A02BC01
ATC
omeprazole; systemic
1.5
10.6
390
2758
O24.1
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, non-insulin-dependent
4.2
10.5
39
95
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.7
10.5
218
1331
N91.0
ICD-10 Finland
Primary amenorrhoea
7.7
10.4
23
30
SPAT1283
SPAT
Restricted health certificate
1.4
10.4
653
5134
M03BX02
ATC
tizanidine; oral
1.4
10.4
1125
9688
N97.1
ICD-10 Finland
Female infertility of tubal origin
3.2
10.3
53
170
R09
ICPC
Sinus symptom/complaint
1.7
10.1
227
1417
K02.1
ICD-10 Finland
Caries of dentine
1.4
10.1
1269
11172
SGB10
NOMESCO Finland
Fiiling of rooth of tooth with one root channel
1.8
10.0
192
1142
LAC21
NOMESCO Finland
Laparoscopic destruction of lesion of ovary
3.1
10.0
52
168
N85.0
ICD-10 Finland
Endometrial glandular hyperplasia
4.0
10.0
39
100
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
1.5
9.8
398
2868
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
1.5
9.8
347
2429
SPAT1260
SPAT
Consultation of another employee
1.5
9.8
319
2193
M72.2
ICD-10 Finland
Plantar fascial fibromatosis
1.9
9.8
139
748
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
9.7
393
2830
C09CA06
ATC
candesartan; oral
1.6
9.7
259
1694
J45.9
ICD-10 Finland
Asthma, unspecified
1.6
9.7
273
1812
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.4
9.6
548
4221
G43.9
ICD-10 Finland
Migraine, unspecified
1.7
9.6
200
1219
J01FF01
ATC
clindamycin; systemic
1.5
9.6
415
3031
WX290
NOMESCO Finland
Other blockade of nerve
1.3
9.6
1087
9372
S18
ICPC
Laceration/cut
1.4
9.5
535
4110
M01AE02
ATC
naproxen; oral, rectal
1.3
9.5
1128
9789
L17
ICPC
Foot/toe symptom/complaint
1.5
9.5
395
2864
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
9.5
459
3430
H01
ICPC
Ear pain/earache
1.6
9.4
272
1814
L68.9
ICD-10 Finland
Hypertrichosis, unspecified
17.6
9.4
14
8
E14.9
ICD-10 Finland
Unspecified diabetes mellitus, without complications
4.6
9.4
31
68
A10BG03
ATC
pioglitazone; oral
6.2
9.4
24
39
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.6
9.3
252
1652
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.9
9.2
135
734
SPAT1254
SPAT
Administration of medicine
1.6
9.2
230
1479
SPAT1153
SPAT
Removal of sutures
1.5
9.2
406
2975
N06AB10
ATC
escitalopram; oral
1.4
9.2
504
3847
B03BA03
ATC
hydroxocobalamin; parenteral
2.9
9.2
54
190
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
2.1
9.2
101
492
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.1
9.1
103
507
H02AB09
ATC
hydrocortisone; systemic
3.9
9.1
36
94
A10BD07
ATC
metformin and sitagliptin; systemic
4.3
9.1
32
75
C10AA05
ATC
atorvastatin; oral
1.7
9.1
177
1060
J01CA08
ATC
pivmecillinam; oral
1.3
9.1
998
8531
P06
ICPC
Sleep disturbance
1.7
9.1
208
1306
TLC00
NOMESCO Finland
Insertion of intrauterine device
1.6
9.1
231
1490
M79.7
ICD-10 Finland
Fibromyalgia
2.2
9.0
86
394
R06.0
ICD-10 Finland
Dyspnoea
1.5
9.0
320
2241
ACC51
NOMESCO Finland
Release of median nerve
2.0
9.0
109
556
C09AA02
ATC
enalapril; systemic
2.0
9.0
111
570
M54.4
ICD-10 Finland
Lumbago with sciatica
1.5
8.8
280
1908
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
1.6
8.8
207
1311
Z31.3
ICD-10 Finland
Other assisted fertilization methods
5.2
8.8
26
51
D06
ICPC
Abdominal pain localized other
1.7
8.8
187
1149
H02AB06
ATC
prednisolone; systemic
1.3
8.8
704
5729
G02CB03
ATC
cabergoline; oral (prolactine inhibitors)
5.4
8.7
25
47
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.3
8.7
999
8579
O82.10
ICD-10 Finland
Delivery by emergency caesarean section
1.6
8.7
227
1479
J01FA10
ATC
azithromycin; systemic
1.3
8.6
1257
11171
N06AX11
ATC
mirtazapine; oral
1.4
8.6
506
3907
A10BH05
ATC
linagliptin; oral
5.5
8.6
24
44
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.5
8.6
294
2043
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
1.9
8.5
131
728
A10BX07
ATC
[U] liraglutide; parenteral
7.4
8.4
19
26
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.0
8.4
109
569
X07
ICPC
Menstruation irregular/frequent
2.3
8.4
77
348
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
1.8
8.4
130
726
ULC02
NOMESCO Finland
Hysteroscopy
1.9
8.3
112
592
K04.0
ICD-10 Finland
Pulpitis
1.6
8.3
241
1609
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
8.3
632
5088
6289A
ICD-9 Finland
Infertility, female, Of unspecified origin[STERILITAS ET INFERTILITAS MULIERIS NUD PRIM]
5.8
8.3
22
38
N05CF01
ATC
zopiclone; oral
1.4
8.3
377
2776
Z35.2
ICD-10 Finland
Supervision of pregnancy with other poor reproductive or obstetric history
2.1
8.2
90
440
SPAT1216
SPAT
Assessment of functional ability
1.8
8.2
143
827
A10AE04
ATC
insulin glargine; parenteral
2.0
8.2
101
518
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
1.8
8.2
148
865
A06AC01
ATC
ispaghula (psylla seeds); oral
1.5
8.1
296
2082
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
6.1
8.1
21
35
M79.0
ICD-10 Finland
Rheumatism, unspecified
2.5
8.1
61
250
R42
ICD-10 Finland
Dizziness and giddiness
1.5
8.1
266
1828
C10AA01
ATC
simvastatin; oral
1.7
8.1
156
933
E66.1
ICD-10 Finland
Drug-induced obesity
8.2
8.1
17
21
N84.0
ICD-10 Finland
Polyp of corpus uteri
1.9
8.0
110
588
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.7
8.0
162
982
R03BA05
ATC
fluticasone; inhalant
1.5
8.0
320
2294
P01AB01
ATC
metronidazole; oral, rectal
1.3
8.0
753
6255
N85.1
ICD-10 Finland
Endometrial adenomatous hyperplasia
5.5
8.0
22
40
J01DA01
ATC
[U] cefalexin; systemic
1.3
7.9
1132
9968
M02AA07
ATC
piroxicam; topical
1.4
7.9
404
3036
K86
ICPC
Hypertension uncomplicated
2.4
7.9
62
261
UJF32
NOMESCO Finland
Coloscopy
1.5
7.8
260
1789
P03
ICPC
Feeling depressed
1.5
7.8
307
2193
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
1.6
7.8
212
1392
L08
ICPC
Shoulder symptom/complaint
1.6
7.8
227
1517
G03HA01
ATC
cyproterone; systemic
8.5
7.8
16
19
O04.9
ICD-10 Finland
Medical abortion, complete or unspecified, without complication
0.6
7.8
170
2540
E03.89
ICD-10 Finland
Other specified hypothyroidism
2.5
7.8
58
237
121
Kela drug reimbursment
Severe hypofunction of sexual glands
3.8
7.7
31
83
W84
ICPC
Pregnancy high risk
1.6
7.7
177
1111
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
2.2
7.7
74
341
M25.5
ICD-10 Finland
Pain in joint
1.4
7.7
496
3880
Z30.4
ICD-10 Finland
Surveillance of contraceptive drugs
0.7
7.7
188
2741
A10BK01
ATC
dapagliflozin; oral
2.9
7.6
44
153
160
Kela drug reimbursment
exenatide
4.7
7.6
24
51
J01FA06
ATC
roxithromycin; oral
1.3
7.6
652
5333
R11
ICD-10 Finland
Nausea and vomiting
1.7
7.6
155
945
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.5
7.6
281
1983
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
2.1
7.6
79
380
R73.0
ICD-10 Finland
Abnormal glucose tolerance test
3.7
7.6
31
85
A02BC05
ATC
esomeprazole; systemic
1.3
7.5
546
4352
R02
ICPC
Shortness of breath/dyspnoea
1.6
7.5
181
1151
R01AD09
ATC
mometasone; nasal
1.3
7.5
916
7872
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.3
7.5
609
4940
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
7.5
204
1344
Z63.7
ICD-10 Finland
Other stressful life events affecting family and household
2.5
7.4
55
223
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
80.4
7.4
8
*
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
80.4
7.4
8
*
M79.1
ICD-10 Finland
Myalgia
1.5
7.4
269
1889
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.5
7.4
281
1993
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.4
7.4
428
3287
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.8
7.4
114
636
A03
ICPC
Fever
1.4
7.3
419
3210
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.3
7.3
1007
8781
A01
ICPC
Pain general/multiple sites
1.8
7.3
121
688
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.8
7.3
121
689
SGA02
NOMESCO Finland
Opening and dilatation of root canal of tooth
1.6
7.3
214
1429
J01AA02
ATC
doxycycline; systemic
1.3
7.3
1253
11248
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.9
7.3
42
146
E30.1
ICD-10 Finland
Precocious puberty
+∞
7.3
7
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
7.3
7
*
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
7.3
7
*
SPAT1360
SPAT
Extensive global examination
1.9
7.3
100
537
N06AB06
ATC
sertraline; oral
1.5
7.2
249
1726
O13
ICD-10 Finland
Gestational [pregnancy-induced] hypertension
1.6
7.2
172
1093
O80.0
ICD-10 Finland
Spontaneous vertex delivery
0.8
7.2
688
8124
N71.0
ICD-10 Finland
Acute inflammatory disease of uterus
1.8
7.2
111
621
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.3
7.2
745
6252
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.4
7.1
443
3437
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.7
7.1
157
979
N03AX11
ATC
topiramate; oral
2.1
7.1
75
362
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
1.9
7.1
93
491
K04.00
ICD-10 Finland
Hyperemia of pulp
1.9
7.1
106
584
D07AC01
ATC
betamethasone; topical
1.3
7.1
513
4082
H66.9
ICD-10 Finland
Otitis media, unspecified
1.7
7.1
148
905
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
1.7
7.0
129
760
R05FB02
ATC
cough suppressants and expectorants
1.4
7.0
457
3577
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
2.9
7.0
40
138
H66.0
ICD-10 Finland
Acute suppurative otitis media
1.6
7.0
173
1111
SPAT1097
SPAT
Recording of ECG
1.7
7.0
129
764
K04.08
ICD-10 Finland
Other specified pulpit
1.6
7.0
160
1004
SPAT1211
SPAT
Application of soft bandage
1.7
7.0
132
785
D01
ICPC
Abdominal pain/cramps general
1.5
7.0
257
1811
WX722
NOMESCO Finland
PEEP
3.3
6.9
32
97
T83
ICPC
Overweight
2.6
6.9
46
177
R05
ICPC
Cough
1.4
6.9
423
3279
N92.5
ICD-10 Finland
Other specified irregular menstruation
1.7
6.8
124
728
R01BA52
ATC
pseudoephedrine, combinations; oral
1.4
6.8
435
3387
N03AX09
ATC
lamotrigine; oral
1.7
6.8
129
768
S10
ICPC
Boil/carbuncle
1.9
6.8
90
474
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.9
6.8
100
548
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.5
6.8
49
198
F32.1
ICD-10 Finland
Moderate depressive episode
1.6
6.8
160
1016
N05BA04
ATC
oxazepam; oral
1.4
6.8
418
3238
E28.8
ICD-10 Finland
Other ovarian dysfunction
40.2
6.8
8
*
C09DA01
ATC
losartan and diuretics; oral
2.4
6.7
54
229
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.8
6.7
109
620
N05BA01
ATC
diazepam; systemic, rectal
1.6
6.7
161
1026
P76
ICPC
Depressive disorder
1.6
6.7
185
1219
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.4
6.7
324
2407
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
1.9
6.7
87
457
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
1.7
6.7
128
768
SPAT1312
SPAT
General health counselling
1.3
6.7
712
5980
L12
ICPC
Hand/finger symptom/complaint
1.5
6.7
245
1725
SPAT1305
SPAT
Counselling and guidance related to physical exercise
1.6
6.7
157
995
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.5
6.7
198
1331
N20.1
ICD-10 Finland
Calculus of ureter
3.0
6.6
36
123
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
1.8
6.6
106
600
WX725
NOMESCO Finland
Noninvasive ventilation
2.1
6.6
67
321
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.4
6.5
327
2441
R2110
NOMESCO Finland
Giving the first information
1.6
6.5
159
1017
Q61.3
ICD-10 Finland
Polycystic kidney, unspecified
10.1
6.5
12
12
R96
ICPC
Asthma
1.7
6.5
128
771
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
2.3
6.5
55
239
SGC10
NOMESCO Finland
Covering pulpa of tooth
1.5
6.5
236
1660
OAB72
NOMESCO Finland
Weight control and weight loss guidance
4.0
6.5
24
61
C10AB05
ATC
fenofibrate; oral
5.3
6.5
18
34
N91
ICD-10 Finland
Absent, scanty and rare menstruation
5.7
6.4
17
30
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
2.9
6.4
37
129
HAMTE
NOMESCO Finland
NA
4.3
6.4
22
52
M01AE01
ATC
ibuprofen; systemic, rectal
1.5
6.4
1828
17476
C10AA07
ATC
rosuvastatin; oral
1.7
6.4
125
753
M01AH05
ATC
etoricoxib; oral
1.3
6.4
900
7826
O20.0
ICD-10 Finland
Threatened abortion
1.9
6.4
93
512
R52.9
ICD-10 Finland
Pain, unspecified
1.7
6.4
128
775
B81
ICPC
Anaemia vit B12/folate deficiency
3.2
6.3
31
99
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
2.0
6.3
78
402
O20.9
ICD-10 Finland
Haemorrhage in early pregnancy, unspecified
1.7
6.3
121
726
K85
ICPC
Elevated blood pressure
1.8
6.3
98
551
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.6
6.3
139
867
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.7
6.3
124
748
O36.6
ICD-10 Finland
Maternal care for excessive fetal growth
1.7
6.3
136
845
E24.0
ICD-10 Finland
Pituitary-dependent Cushing disease
+∞
6.3
6
*
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
6.2
1512
14042
R4190
NOMESCO Finland
Nutritional therapy
2.2
6.2
60
281
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.3
6.2
54
240
SPAT1028
SPAT
Ultrasound examination of paranasal sinuses
1.7
6.2
135
836
N02AA05
ATC
oxycodone; systemic
1.8
6.2
97
546
F34.1
ICD-10 Finland
Dysthymia
1.9
6.2
85
456
Z31.6
ICD-10 Finland
General counselling and advice on procreation
2.6
6.2
41
159
K10.3
ICD-10 Finland
Alveolitis of jaws
1.7
6.2
111
653
KMAK
NOMESCO Finland
NA
1.3
6.1
1154
10365
QBJ30
NOMESCO Finland
Correction of abdominal apron
3.2
6.1
30
96
N05CF02
ATC
zolpidem; oral
1.4
6.1
276
2021
L29.9
ICD-10 Finland
Pruritus, unspecified
2.5
6.1
44
178
M01AB05
ATC
diclofenac; systemic, rectal
1.3
6.1
1069
9519
SGC00
NOMESCO Finland
Local medication of root channels of tooth
1.5
6.1
220
1543
TEW99
NOMESCO Finland
Other minor procedure in surgery of teeth, jaws, mouth and pharynx
1.9
6.1
86
466
SPAT1307
SPAT
Psychosocial counselling and guidance
1.5
6.0
229
1621
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
2.5
6.0
46
190
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
1.3
6.0
415
3265
N92.0
ICD-10 Finland
Excessive and frequent menstruation with regular cycle
1.4
6.0
249
1797
Mortality – FinRegistry
↥Association
Association between endpoint E4_PCOS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PCOS | 1.36 [1.07, 1.73] | 0.012 |
| Birth year | 0.992 [0.98, 1.0] | 0.066 |
During the follow-up period (1.1.1998 — 31.12.2019), 104 out of 10334 females with E4_PCOS died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have E4_PCOS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.115% | No data |
| 5 | 0.624% | No data |
| 10 | 1.619% | No data |
| 15 | 3.275% | No data |
| 20 | 6.043% | No data |
Relationships between endpoints
↥Index endpoint: E4_PCOS – Polycystic ovarian syndrome
GWS hits: 7
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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