No definition available.
Benign neoplasm: Long bones of lower limb
DOID EFO Endpoint Browser PheWeb
CD2_BENIGN_BONE_LONG_LOWER
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1246 |
4. Check minimum number of eventsNone |
1246 |
5. Include endpointsNone |
1246 |
6. Filter based on genotype QC (FinnGen only) |
1246 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D16
- Name in latin
- Neoplasma benignum ossium longorum membri inferioris
Similar endpoints
↥List of similar endpoints to
Benign neoplasm: Long bones of lower limb
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm: Long bones of lower limb
- Benign neoplasm of bone and articular cartilage
- Benign neoplasm of bone and articular cartilage
- Benign neoplasms
- Benign neoplasms
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10196 | 4557 | 5600 |
| Only index persons | 9666 | 4381 | 5285 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.14 | 0.13 | 0.16 |
| Only index persons | 0.18 | 0.16 | 0.20 |
| Median age at first event (years) | |||
| Whole population | 23.26 | 27.03 | 20.08 |
| Only index persons | 23.02 | 26.68 | 19.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1246 | 709 | 537 |
| Unadjusted period prevalence (%) | 0.24 | 0.24 | 0.24 |
| Median age at first event (years) | 34.76 | 35.81 | 33.37 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1115
- Matched controls
- 11147
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D16.2
ICD-10 Finland
Benign neoplasm: Long bones of lower limb
+∞
323.0
790
*
21306
ICD-8 Finland
Benign neoplasm of bone and cartilage, Ossium longorum extremitatis inferioris
+∞
202.4
188
*
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
71.2
183.9
209
36
2137A
ICD-9 Finland
Benign neoplasm of bone and articular cartilage, Long bones of lower limb
+∞
168.1
157
*
9102
FHL
Trepanation or removal of the local bone process
93.3
106.5
117
14
NGR20
NOMESCO Finland
Intralesional or marginal excision of tumor of knee or lower leg
194.9
103.3
106
6
NFR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of hip or thigh
151.5
67.8
71
5
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
11.7
62.2
119
113
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
3.8
41.7
197
597
NF3AA
NOMESCO Finland
Femur X-ray examination
15.7
38.8
64
43
NK6CT
NOMESCO Finland
Bone biopsy with CT guidance
78.7
34.0
38
5
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
8.3
30.5
69
88
NK6BN
NOMESCO Finland
Bone dynamic isotope examination
28.3
24.6
33
12
NG1DG
NOMESCO Finland
Knee and lower leg very extensive MRI examination with high intensity magnet
49.5
24.4
29
6
NHR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of ankle or foot
57.4
24.1
28
5
NGK05
NOMESCO Finland
Partial or total excision of bone of lower leg
85.2
22.7
25
*
NG4AA
NOMESCO Finland
Lower leg X-ray examination
5.4
21.5
66
129
NFK10
NOMESCO Finland
Fenestration or partial or total excision of bone of femur
51.1
21.2
25
5
D16.3
ICD-10 Finland
Benign neoplasm: Short bones of lower limb
106.9
19.6
21
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
2.2
19.2
213
1066
D16.1
ICD-10 Finland
Benign neoplasm: Short bones of upper limb
30.6
18.4
24
8
9101
FHL
Bone biopsy
44.8
18.3
22
5
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
3.7
18.1
81
231
D16.0
ICD-10 Finland
Benign neoplasm: Scapula and long bones of upper limb
42.7
17.3
21
5
M79.6
ICD-10 Finland
Pain in limb
1.8
17.1
384
2509
NF1AA
NOMESCO Finland
Hip X-ray examination
3.1
17.0
97
333
NE1DG
NOMESCO Finland
Pelvic, hip and femur very extensive MRI examination with high intensity magnet
24.9
16.0
22
9
M25.5
ICD-10 Finland
Pain in joint
1.8
15.7
320
2012
WX320
NOMESCO Finland
Spinalanesthesy
1.9
15.5
245
1407
C40.22
ICD-10 Finland
Chondrosarcoma of the long bones of the lower extremity
162.2
15.5
16
*
C40.20
ICD-10 Finland
Malignant tumor of the long bones of the lower extremity without histology
+∞
13.6
13
*
N03AX16
ATC
pregabalin; oral
1.8
13.0
238
1431
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
2.2
12.7
133
643
NGR30
NOMESCO Finland
Extensive or radikal excision of tumor of knee or lower leg
+∞
12.5
12
*
9104
FHL
Autogenous bone graft
131.4
12.5
13
*
NG1AD
NOMESCO Finland
Knee CT examination
6.5
11.9
30
47
M85.4
ICD-10 Finland
Solitary bone cyst
47.2
11.9
14
*
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
3.9
11.8
48
128
ZZH40
NOMESCO Finland
Substitute of bone
7.8
11.7
26
34
9220/3-C40.2
ICD-O-3
Chondrosarcoma, NOS, of long bones of lower limb and associated joints
+∞
11.5
11
*
D48.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Connective and other soft tissue
5.1
11.3
35
71
N06AX21
ATC
duloxetine; oral
2.1
11.0
124
617
N02AX02
ATC
tramadol; systemic, rectal
1.6
10.9
407
2983
N02AJ06
ATC
codeine and paracetamol; systemic
1.6
10.8
399
2913
9103
FHL
Partial or complete bone removal
18.0
10.7
16
9
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.7
10.7
275
1822
NFK99
NOMESCO Finland
Other operation on bone of femur
32.8
10.3
13
*
M01AH05
ATC
etoricoxib; oral
1.5
10.2
604
4894
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
10.2
470
3604
Q78.6
ICD-10 Finland
Multiple congenital exostoses
26.3
9.8
13
5
N02BE01
ATC
paracetamol; systemic, rectal
1.6
9.6
895
7980
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.6
9.6
265
1786
M54.5
ICD-10 Finland
Low back pain
1.6
9.6
339
2431
NFU20
NOMESCO Finland
Removal of internal fixation device from femur
9.2
9.5
19
21
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
2.5
9.2
72
300
D16.8
ICD-10 Finland
Benign neoplasm: Pelvic bones, sacrum and coccyx
37.0
9.0
11
*
M01AE01
ATC
ibuprofen; systemic, rectal
1.8
8.9
991
9136
ZXA05
NOMESCO Finland
Left side
1.7
8.9
226
1487
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
8.7
381
2859
N03AX12
ATC
gabapentin; oral
1.8
8.5
147
859
SPAT1312
SPAT
General health counselling
1.5
8.5
327
2382
M12.2
ICD-10 Finland
Villonodular synovitis (pigmented)
27.7
8.5
11
*
X58
ICD-10 Finland
Exposure to other specified factors
1.8
8.4
153
910
M16.1
ICD-10 Finland
Other primary coxarthrosis
2.1
8.4
91
447
B01AB05
ATC
enoxaparin; parenteral
1.6
8.4
262
1813
C40.2
ICD-10 Finland
Malignant neoplasm: Long bones of lower limb
+∞
8.3
8
*
S18
ICPC
Laceration/cut
1.5
8.3
386
2926
L15
ICPC
Knee symptom/complaint
1.7
8.3
200
1293
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.1
8.3
91
448
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
5.2
8.2
24
47
SPAT1153
SPAT
Removal of sutures
1.5
8.2
290
2073
ZZH31
NOMESCO Finland
Bone allograft, small pieces
10.1
8.0
15
15
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
2.0
8.0
102
534
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.7
7.8
156
956
D21.2
ICD-10 Finland
Benign neoplasm: Connective and other soft tissue of lower limb, including hip
10.9
7.8
14
13
Z47.8
ICD-10 Finland
Other specified orthopaedic follow-up care
9.5
7.8
15
16
NG4AD
NOMESCO Finland
Lower leg CT
18.5
7.6
11
6
NF3BA
NOMESCO Finland
Femur extensive X-ray examination
18.5
7.6
11
6
NFR30
NOMESCO Finland
Extended excision of soft tissue tumour of hip or thigh
25.2
7.6
10
*
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.7
7.6
169
1067
M01AE02
ATC
naproxen; oral, rectal
1.4
7.3
595
4991
9180/3-C40.2
ICD-O-3
Osteosarcoma, NOS, of long bones of lower limb and associated joints
+∞
7.3
7
*
NGR99
NOMESCO Finland
Other operation for tumour of knee or lower leg
+∞
7.3
7
*
C40.21
ICD-10 Finland
Osteosarcoma of the long bones of the lower extremity
+∞
7.3
7
*
NK6DT
NOMESCO Finland
Bone biopsy with MRI guidance
+∞
7.3
7
*
C40.29
ICD-10 Finland
Malignant tumor of the long bones of the lower extremity other or unspecified histology
+∞
7.3
7
*
A02BC02
ATC
pantoprazole; systemic
1.4
7.2
604
5086
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
7.2
261
1863
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
7.1
354
2702
M01AB05
ATC
diclofenac; systemic, rectal
1.4
7.1
668
5737
NGA20
NOMESCO Finland
Exploration of soft tissue knee or lower leg, open
12.1
7.1
12
10
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
2.4
7.0
56
240
UKC02
NOMESCO Finland
Cystoscopy
1.8
7.0
120
703
J01AA02
ATC
doxycycline; systemic
1.4
6.9
767
6775
ZXA00
NOMESCO Finland
Right side
1.5
6.9
228
1593
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.5
6.8
230
1615
NK6AN
NOMESCO Finland
Total body bone isotope imaging
3.8
6.8
27
73
R22.4
ICD-10 Finland
Localized swelling, mass and lump, lower limb
3.2
6.7
32
101
AA1AD
NOMESCO Finland
CT of head and brain
1.6
6.5
190
1288
M02AA07
ATC
piroxicam; topical
1.4
6.5
311
2350
NFR99
NOMESCO Finland
Other operation for tumour of hip or thigh
70.2
6.4
7
*
NGK99
NOMESCO Finland
Other operation on bone of knee or lower leg
14.4
6.4
10
7
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
1.8
6.4
110
646
NER20
NOMESCO Finland
Incomplete excision of soft tissue tumour of pelvis
+∞
6.3
6
*
NFA20
NOMESCO Finland
Exploration of hip joint or femur
26.8
6.2
8
*
Z00.0
ICD-10 Finland
General medical examination
1.6
6.2
169
1127
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
2.6
6.1
43
172
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.3
6.1
55
251
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
854
7317
1.53
10.69
4.6
3.8
9.8
10.5
mm/h
0.96
788
6816
182
1120
1.73
9.80
4.0
4.0
31.9
31.3
%
0.26
123
789
172
1057
1.73
9.29
7.3
6.1
—
—
—
0
0
574
4652
1.43
8.76
3.9
3.9
—
—
—
0
0
854
7452
1.46
8.66
8.1
7.4
78.6
76.6
u/l
0.60
802
7031
316
2310
1.49
8.17
2.3
2.2
—
—
—
0
0
542
4420
1.40
7.64
7.9
6.8
1.2
1.2
mmol/l
0.12
445
3776
50
217
2.36
7.23
1.4
1.8
20349.4
12719.1
e6/l
0.44
39
158
491
3989
1.38
6.87
7.1
6.1
1.2
1.2
mmol/l
0.22
434
3653
1105
10318
1.63
6.86
14.3
12.3
20.6
22.2
mg/l
0.89
883
8029
473
3843
1.37
6.53
4.9
4.9
36.4
36.3
g/l
0.09
426
3600
651
5571
1.35
6.39
4.9
4.8
6.5
6.6
mmol/l
0.30
610
5169
347
2691
1.40
6.31
2.3
2.1
275.5
224.2
u/l
0.20
332
2554
727
6363
1.34
5.96
4.6
4.0
117.3
1915.3
e6/l
—
6
86
51
248
2.10
5.68
1.4
1.5
—
—
—
0
0
14
33
4.28
5.56
3.4
1.9
81.5
70.0
ug/l
0.16
14
33
576
4961
1.30
4.90
6.2
6.2
11.0
11.1
umol/l
0.05
543
4699
307
2461
1.33
4.31
2.8
2.5
2154.3
5645.6
umol/l
1.05
274
2182
364
2995
1.30
4.23
2.6
2.6
54.3
56.4
u/l
0.57
328
2788
859
7879
1.29
4.13
4.1
3.9
14.7
14.6
pmol/l
0.97
785
7258
124
858
1.49
4.09
2.8
2.4
0.2
0.2
g/l
0.18
118
801
1087
10328
1.41
3.99
16.0
13.5
139.7
139.6
mmol/l
0.13
1055
10054
116
801
1.49
3.88
3.6
4.6
38.2
25.0
ug/l
0.15
93
652
364
3027
1.29
3.84
3.0
3.3
2.3
2.4
mmol/l
0.31
318
2702
221
1720
1.35
3.76
1.4
1.3
7.4
10.0
u/ml
0.40
92
701
405
3424
1.27
3.73
3.2
3.2
22.4
42.8
ng/l
2.17
252
2110
1088
10363
1.39
3.71
16.0
13.6
3.9
3.9
mmol/l
0.20
1053
10069
25
112
2.26
3.49
1.4
1.2
—
—
—
0
0
93
632
1.51
3.38
3.4
4.1
70.5
81.7
ng/l
0.69
84
572
32
161
2.01
3.36
1.8
1.6
—
—
—
0
0
92
625
1.51
3.35
2.2
2.9
67.3
67.3
g/l
0.03
85
578
56
339
1.68
3.30
2.1
1.9
—
—
—
0
0
128
933
1.41
3.25
4.2
4.4
233.5
235.6
u/l
0.08
123
888
18
72
2.52
3.22
2.3
2.1
—
—
—
0
0
21
91
2.33
3.18
1.2
1.4
15062.0
187130.6
e6/l
0.97
11
66
225
1801
1.30
3.13
1.4
1.3
22.2
28.9
iu/ml
0.61
76
554
154
1177
1.35
2.95
6.6
6.0
1.0
1.0
mmol/l
0.00
146
1100
385
3313
1.23
2.91
3.3
3.1
—
—
—
0
0
23
109
2.13
2.85
1.6
1.7
48.3
58.4
%
0.55
16
80
34
187
1.84
2.81
1.6
1.8
—
—
—
0
0
7
14
5.02
2.73
1.9
1.3
—
—
—
0
0
49
306
1.63
2.62
2.1
2.3
577.9
322.6
ug/l
0.27
44
285
45
275
1.66
2.61
1.4
1.2
3.7
8.6
u/ml
—
8
48
67
452
1.51
2.58
1.8
2.1
39.4
39.0
u/l
0.07
59
407
19
87
2.20
2.58
1.1
1.1
—
—
—
0
0
42
253
1.68
2.58
2.6
2.8
—
—
—
0
0
16
68
2.37
2.56
1.3
1.3
—
—
—
0
0
127
967
1.35
2.52
20.1
20.2
1.3
1.2
inr
0.17
16
139
633
5779
1.19
2.50
9.7
8.9
4.0
4.0
e9/l
0.33
563
5084
16
69
2.34
2.49
1.3
1.7
—
—
—
0
0
51
328
1.58
2.44
1.4
1.7
—
—
—
0
0
780
7269
1.20
2.40
3.6
3.1
47.4
46.4
u/l
0.13
723
6887
260
2188
1.24
2.38
2.8
3.0
1126.0
1006.1
ng/l
0.16
214
1821
1008
9636
1.24
2.35
12.3
11.0
88.2
87.5
ml/min/173m2
0.48
845
7844
68
472
1.47
2.31
1.6
1.6
—
—
—
0
0
222
1848
1.24
2.24
1.7
1.6
412.8
37831443.8
pmol/l
2.15
183
1586
173
1400
1.27
2.22
1.7
1.9
—
—
—
0
0
47
304
1.57
2.22
1.4
1.3
—
—
—
0
0
100
750
1.36
2.21
2.3
2.3
75.2
73.3
ml/min/173m2
0.20
51
292
43
273
1.60
2.19
1.4
1.2
2.8
2.7
u/ml
—
5
30
87
640
1.39
2.17
3.0
3.4
4.5
4.6
pmol/l
0.26
75
570
6
14
4.30
2.15
1.2
1.1
5.1
6.6
nmol/l
—
6
14
448
4008
1.18
2.15
2.7
2.3
77.3
74.5
nmol/l
0.84
401
3650
546
4967
1.18
2.14
3.8
3.3
0.0
0.0
estimate
0.80
101
894
816
7682
1.18
2.07
3.4
3.3
—
—
—
0
0
16
77
2.09
1.97
2.3
2.1
14.8
13.9
%
—
8
39
538
4915
1.17
1.95
3.8
3.3
0.0
0.0
estimate
0.00
99
909
978
9373
1.20
1.93
5.0
4.5
1.8
2.0
mu/l
0.91
899
8722
43
283
1.54
1.92
1.5
1.5
248.2
294.6
ug/g
0.78
24
166
538
4920
1.16
1.92
4.9
4.5
0.0
0.0
estimate
0.50
101
935
202
1695
1.23
1.90
3.0
3.5
485.0
508.8
ng/l
0.03
129
1191
186
1548
1.24
1.89
1.7
1.8
1.5
1.4
%
0.12
159
1397
20
107
1.88
1.87
1.3
1.7
23.4
21.0
nmol/l
0.26
20
101
23
129
1.80
1.86
1.3
1.4
—
—
—
0
0
23
129
1.80
1.86
1.3
1.4
—
—
—
0
0
402
3600
1.17
1.86
1.9
1.9
103.1
95.9
pmol/l
1.69
213
1926
1013
9751
1.21
1.85
4.5
4.0
5.8
5.8
mmol/l
0.36
919
9022
168
1388
1.24
1.83
1.9
2.2
30.2
29.5
s
0.41
159
1346
23
130
1.78
1.82
1.3
1.4
—
—
—
0
0
52
361
1.46
1.82
1.7
1.9
—
—
—
0
0
296
2593
1.19
1.78
4.4
3.6
0.0
0.0
estimate
1.28
98
908
949
9093
1.18
1.77
5.7
5.1
38.7
39.0
mmol/mol
0.46
881
8539
18
95
1.91
1.76
1.1
1.1
27.4
42.8
mg/l
1.98
18
75
8
30
2.68
1.72
1.9
2.1
—
—
—
0
0
39
259
1.52
1.70
1.7
1.7
—
—
—
0
0
17
90
1.90
1.65
1.0
1.1
225.8
258.0
mg/l
0.56
17
78
117
939
1.27
1.65
10.2
9.4
1.2
1.2
mmol/l
0.07
95
757
109
869
1.28
1.62
2.2
2.2
13.6
13.2
nmol/l
0.24
98
790
422
3828
1.15
1.62
4.1
3.4
—
—
—
0
0
43
295
1.47
1.62
1.2
1.1
—
—
—
0
0
117
944
1.26
1.59
10.2
9.3
12.6
12.5
kpa
0.03
110
908
117
944
1.26
1.59
10.3
9.3
5.1
5.1
kpa
0.29
110
904
230
1994
1.19
1.56
1.5
1.5
19.9
20.8
nmol/l
0.40
191
1725
173
1462
1.21
1.54
4.6
3.5
0.8
0.8
mmol/l
0.60
159
1381
22
130
1.70
1.53
1.3
1.3
—
—
—
0
0
287
2543
1.17
1.50
1.3
1.3
0.8
1.7
u/ml
2.31
76
687
503
4642
1.14
1.48
2.8
2.8
113.7
110.5
ug/l
0.13
473
4332
9
37
2.44
1.48
2.1
2.3
—
—
—
0
0
76
586
1.32
1.47
2.5
2.4
3702.3
4137.5
u/l
0.07
22
246
219
1901
1.18
1.47
2.6
2.5
6.8
6.1
e6/l
0.27
194
1681
54
395
1.38
1.47
1.5
1.4
—
—
—
0
0
22
132
1.68
1.46
1.3
1.3
—
—
—
0
0
22
132
1.68
1.46
1.3
1.3
—
—
—
0
0
317
2837
1.16
1.45
4.7
4.1
1.9
2.0
ug/l
0.38
287
2585
193
1662
1.19
1.42
2.2
2.0
—
—
—
0
0
1190
11715
1.35
1.41
21.7
18.0
136.5
137.2
g/l
1.12
1178
11563
165
1402
1.20
1.40
2.3
2.5
88.0
115.0
ug/g
0.63
126
1115
1188
11696
1.34
1.37
21.8
17.9
256.7
254.2
e9/l
0.69
1167
11421
320
2877
1.15
1.37
3.7
3.2
8.1
8.2
mmol/l
0.08
270
2460
1189
11710
1.34
1.34
21.7
17.8
4.5
4.6
e12/l
1.06
1167
11421
87
693
1.27
1.34
4.3
3.8
1.2
1.2
mmol/l
1.15
74
607
18
105
1.72
1.33
1.1
1.2
57.4
52.4
u/l
—
8
71
24
152
1.59
1.32
1.5
2.0
—
1330.0
—
0
8
1189
11714
1.33
1.30
21.7
17.9
6.7
6.7
e9/l
0.30
1166
11416
44
319
1.39
1.28
2.5
1.5
0.2
0.2
g/l
0.95
39
301
99
806
1.25
1.28
1.3
1.2
93.6
147.6
iu/ml
1.27
40
326
168
1444
1.19
1.27
1.8
1.7
1135.9
1168.5
nmol/l
0.19
124
1116
257
2292
1.15
1.23
1.9
1.8
1.1
1.0
mg/l
0.13
198
1705
115
957
1.22
1.23
1.7
1.8
—
—
—
0
0
76
604
1.28
1.21
1.6
1.4
22.0
24.5
iu/l
0.27
67
504
14
78
1.80
1.21
1.5
1.5
—
—
—
0
0
14
78
1.80
1.21
1.1
1.4
—
—
—
0
0
13
71
1.84
1.19
2.2
2.9
—
—
—
0
0
14
79
1.78
1.17
2.2
2.2
467.4
648.3
e6/l
—
9
66
16
95
1.69
1.14
1.3
1.3
—
—
—
0
0
23
151
1.53
1.12
1.0
1.2
—
—
—
0
0
13
219
0.59
1.09
1.4
1.7
—
—
—
0
0
35
252
1.40
1.09
1.1
1.1
1.2
2.2
u/ml
0.47
13
115
280
2534
1.14
1.09
3.2
2.9
0.3
0.4
e6/l
0.21
220
1900
114
967
1.20
1.03
1.7
1.8
—
—
—
0
0
205
1824
1.15
1.03
2.3
2.2
—
—
—
0
0
1048
10239
1.15
1.02
4.7
4.4
2.8
2.8
mmol/l
0.00
966
9579
10
53
1.89
1.01
1.4
3.1
795.8
853.5
u/ml
—
10
53
26
180
1.45
1.01
2.3
2.3
133.9
131.1
g/l
0.21
21
138
112
951
1.20
1.01
2.1
2.1
346.3
370.9
nmol/l
0.78
102
886
7
35
2.01
1.00
1.4
1.4
10.3
8.5
ug/l
—
7
35
24
165
1.46
0.97
2.8
2.2
5.7
4.6
umol/l
0.39
14
120
9
50
1.81
0.96
1.2
1.3
—
—
—
0
0
9
50
1.81
0.96
1.2
1.3
—
—
—
0
0
12
69
1.75
0.96
1.1
1.0
—
—
—
0
0
174
1541
1.15
0.94
2.9
2.9
2.4
2.4
mmol/l
0.43
154
1359
77
635
1.23
0.94
1.1
1.0
—
—
—
0
0
32
234
1.38
0.94
1.3
1.3
—
—
—
0
0
67
546
1.24
0.92
4.4
3.2
1.8
1.6
mmol/l
0.10
56
408
993
9693
1.12
0.88
4.0
3.6
1.3
1.3
mmol/l
1.11
913
9069
30
220
1.37
0.88
1.8
2.5
1.0
0.9
nmol/l
0.30
24
191
8
43
1.87
0.87
1.1
1.1
1659.3
1559.6
miu/ml
—
8
43
201
1809
1.13
0.87
1.4
1.5
—
—
—
0
0
8
45
1.78
0.84
1.3
1.2
—
—
—
0
0
8
45
1.78
0.84
1.3
1.2
—
—
—
0
0
43
336
1.29
0.84
7.0
7.0
2.5
1.6
%
0.73
38
313
81
681
1.20
0.84
2.0
2.2
5.7
7.7
ug/l
0.70
69
609
137
1206
1.15
0.82
2.5
2.4
25.1
23.9
%
0.37
117
1043
1117
10995
1.15
0.81
11.4
9.5
28.4
27.4
u/l
0.82
1079
10669
148
1312
1.15
0.81
2.4
2.3
2.4
2.4
g/l
0.46
139
1212
285
2631
1.11
0.80
4.0
4.1
6.0
9.7
mg/mmol
1.52
179
1712
42
330
1.28
0.80
2.0
2.0
1.1
2.1
ug/l
0.47
35
301
106
918
1.17
0.79
3.4
3.1
—
—
—
0
0
17
114
1.50
0.79
1.1
1.0
—
—
—
0
0
9
147
0.61
0.79
1.9
1.6
—
—
—
0
0
0
24
0.00
0.79
0.0
1.7
—
—
—
0
0
71
594
1.21
0.78
2.5
2.7
169.1
145.9
ng/l
0.19
62
531
19
131
1.46
0.78
1.1
1.1
—
—
—
0
0
15
221
0.67
0.76
2.9
2.4
128.7
114.3
ug/min
—
9
133
5
24
2.09
0.74
1.0
1.2
—
—
—
0
0
5
24
2.09
0.74
1.0
1.2
116.8
98.4
%
—
5
24
41
326
1.27
0.72
3.2
3.6
870.3
4264.7
u/ml
0.56
33
282
17
117
1.46
0.72
1.4
1.2
—
—
—
0
0
17
117
1.46
0.72
1.1
1.1
—
—
—
0
0
12
76
1.58
0.71
1.6
3.5
14.1
57.1
u/ml
1.31
12
76
7
40
1.75
0.71
2.0
2.3
—
—
—
0
0
7
40
1.75
0.71
2.0
2.3
—
—
—
0
0
7
41
1.71
0.70
1.0
1.3
—
—
—
0
0
57
474
1.21
0.69
2.0
1.9
—
—
—
0
0
5
27
1.86
0.68
1.2
2.0
11.4
17.8
umol/l
—
5
27
1025
10063
1.10
0.67
4.3
4.0
1.4
1.4
mmol/l
0.41
944
9426
169
1533
1.12
0.67
2.8
2.6
0.8
1.1
e6/l
1.07
100
857
14
94
1.49
0.67
1.1
1.1
—
—
—
0
0
23
171
1.35
0.66
1.1
1.1
—
—
—
0
0
29
224
1.30
0.65
1.6
3.6
—
1.7
—
0
24
1029
10110
1.10
0.64
4.4
4.0
4.7
4.7
mmol/l
0.16
953
9518
49
405
1.22
0.64
1.8
1.8
—
—
—
0
0
159
1442
1.12
0.64
2.9
2.8
2.5
2.6
e6/l
0.11
93
772
1008
9896
1.10
0.63
14.8
12.8
40.4
40.6
%
0.38
750
7735
11
71
1.55
0.62
1.1
1.1
3.2
5.5
iu/ml
—
5
17
75
648
1.17
0.61
3.5
2.8
4.8
4.7
kpa
0.23
75
633
36
289
1.25
0.61
1.7
2.2
10.6
11.2
mg/l
0.19
36
265
155
1408
1.12
0.61
2.4
2.4
15.1
13.9
umol/l
1.10
147
1300
28
218
1.29
0.60
5.5
6.2
1511.8
305.0
iu/ml
—
5
32
41
335
1.23
0.60
1.6
1.6
0.1
0.1
iu/ml
0.00
11
55
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
23
174
1.33
0.60
2.4
2.4
17.1
16.3
%
0.34
16
88
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.3
—
—
—
0
0
0
22
0.00
0.59
0.0
2.0
—
2.2
—
0
12
11
72
1.53
0.59
1.2
1.2
—
—
—
0
0
29
228
1.28
0.58
1.6
3.7
31.5
76.1
mg/l
0.87
23
183
29
228
1.28
0.58
1.6
3.7
60.4
31.5
mg/l
0.56
23
183
65
558
1.17
0.58
1.5
1.5
—
—
—
0
0
61
711
0.85
0.58
1.6
1.5
—
—
—
0
0
234
2178
1.09
0.57
4.0
3.5
1.0
1.0
kg/l
0.73
31
292
91
806
1.14
0.55
1.6
1.8
—
—
—
0
0
6
96
0.62
0.52
2.3
1.6
—
—
—
0
0
6
96
0.62
0.52
2.3
1.6
—
—
—
0
0
6
96
0.62
0.52
2.3
1.6
—
—
—
0
0
19
248
0.76
0.52
1.9
1.7
—
—
—
0
0
26
206
1.27
0.51
1.8
3.3
33.8
33.7
umol/l
0.00
21
175
12
167
0.72
0.49
1.8
1.6
—
—
—
0
0
870
8871
0.94
0.49
17.0
14.8
13.6
13.5
%
0.14
856
8687
24
301
0.79
0.49
2.0
1.7
—
—
—
0
0
7
46
1.52
0.48
1.7
1.7
1.8
6.5
nmol/l
—
7
39
126
1150
1.11
0.48
3.0
2.8
5.9
8.0
umol/l
1.14
108
995
104
940
1.12
0.47
2.7
2.6
36.4
89.9
u/l
0.53
86
804
241
2267
1.08
0.47
4.3
3.7
21.1
21.2
%
0.05
104
934
41
346
1.19
0.47
1.8
2.4
91.5
93.4
%
0.24
41
323
23
182
1.27
0.46
1.2
1.2
2.1
5.3
u/ml
1.56
14
76
7
49
1.43
0.46
1.0
1.3
—
—
—
0
0
47
404
1.17
0.44
1.6
1.4
8.3
8.7
u/l
0.09
39
335
19
240
0.79
0.42
1.9
1.7
—
—
—
0
0
42
488
0.86
0.42
1.7
1.7
4.4
3.2
mg/l
0.43
31
342
0
16
0.00
0.41
0.0
2.6
—
0.9
—
0
16
34
401
0.84
0.41
1.1
1.4
—
—
—
0
0
40
465
0.86
0.40
1.5
1.4
—
—
—
0
0
0
17
0.00
0.40
0.0
1.4
—
—
—
0
0
0
17
0.00
0.40
0.0
3.1
—
—
—
0
0
34
287
1.19
0.40
1.3
2.0
3.6
3.8
g/l
0.34
20
215
20
159
1.26
0.40
1.4
1.2
16.5
24.6
u/l
0.49
20
138
85
769
1.11
0.40
3.8
3.6
5.9
5.9
kpa
0.22
85
750
0
18
0.00
0.40
0.0
1.7
—
1.2
—
0
18
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
8
61
1.31
0.39
1.0
1.2
—
—
—
0
0
34
288
1.19
0.39
1.3
2.0
—
—
—
0
0
34
288
1.19
0.39
1.3
2.0
7.2
7.3
g/l
0.01
23
227
10
71
1.41
0.39
1.3
1.2
—
—
—
0
0
84
761
1.11
0.39
3.8
3.7
2.1
1.9
mmol/l
0.22
72
615
113
1225
0.91
0.38
1.8
1.6
—
—
—
0
0
358
3440
1.06
0.38
3.4
3.3
33.1
31.6
u/l
0.31
345
3275
5
36
1.39
0.38
1.8
2.5
—
—
—
0
0
44
383
1.15
0.37
1.3
1.4
—
—
—
0
0
32
272
1.18
0.36
1.1
2.1
2.9
3.1
g/l
0.65
23
219
19
234
0.81
0.36
1.5
1.3
—
—
—
0
0
6
42
1.43
0.35
1.8
1.8
—
—
—
0
0
6
42
1.43
0.35
1.8
1.8
—
—
—
0
0
5
80
0.62
0.35
3.0
3.9
—
—
—
0
0
9
124
0.72
0.35
1.8
1.7
—
—
—
0
0
35
405
0.86
0.35
1.3
1.5
—
—
—
0
0
6
43
1.40
0.35
1.8
1.8
—
—
—
0
0
9
126
0.71
0.35
1.2
1.7
—
—
—
0
0
6
44
1.37
0.34
1.8
1.6
—
—
—
0
0
250
2386
1.06
0.34
1.6
1.6
—
—
—
0
0
6
45
1.33
0.33
1.0
1.7
—
—
—
0
0
11
144
0.76
0.33
1.4
1.6
—
—
—
0
0
6
46
1.31
0.33
1.0
2.4
15.1
202.2
ug/l
—
6
38
31
266
1.17
0.32
1.3
2.0
9.9
10.3
g/l
0.20
25
233
21
174
1.21
0.31
1.1
1.1
9.3
57.8
iu/ml
—
9
43
28
239
1.18
0.31
1.4
1.5
—
10.2
—
0
5
11
84
1.31
0.30
1.8
2.1
—
—
—
0
0
24
203
1.19
0.30
3.1
3.9
57.0
56.1
%
0.14
24
203
7
55
1.27
0.30
1.0
1.1
—
—
—
0
0
8
108
0.74
0.29
1.0
1.1
—
—
—
0
0
108
1009
1.08
0.29
1.7
1.9
—
—
—
0
0
14
173
0.81
0.28
1.6
1.8
—
—
—
0
0
20
167
1.20
0.28
1.3
1.4
—
—
—
0
0
20
167
1.20
0.28
1.3
1.4
—
—
—
0
0
176
1674
1.06
0.28
2.9
2.7
0.7
0.7
ug/l
0.43
106
982
11
85
1.30
0.28
1.0
1.1
—
—
—
0
0
26
224
1.16
0.27
1.3
1.2
—
—
—
0
0
23
197
1.17
0.26
2.9
3.5
4.0
4.1
e9/l
0.17
23
197
68
627
1.09
0.25
1.5
1.6
—
—
—
0
0
78
725
1.08
0.24
1.4
1.3
154.9
232.4
u/ml
0.81
72
675
33
371
0.89
0.24
1.4
1.4
—
—
—
0
0
6
81
0.74
0.24
3.7
2.0
—
—
—
0
0
33
370
0.89
0.24
1.3
1.4
—
—
—
0
0
33
370
0.89
0.24
1.3
1.4
—
—
—
0
0
11
136
0.81
0.23
1.1
1.1
—
—
—
0
0
33
369
0.89
0.23
1.3
1.4
—
—
—
0
0
240
2318
1.04
0.22
2.2
2.1
2.9
2.9
mg/l
0.03
204
2001
5
40
1.25
0.22
1.0
1.0
—
—
—
0
0
31
276
1.13
0.22
1.7
1.9
5.3
4.9
iu/l
—
10
97
5
42
1.19
0.21
1.2
1.0
—
—
—
0
0
12
98
1.23
0.21
2.0
2.2
32.6
32.8
pg
0.05
12
98
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
31
343
0.90
0.19
1.6
1.6
—
—
—
0
0
60
641
0.93
0.18
1.5
1.3
—
—
—
0
0
7
59
1.19
0.18
1.0
1.1
869.8
223.0
iu/ml
—
7
59
17
193
0.88
0.15
1.0
1.0
1.9
2.4
u/ml
—
8
89
9
83
1.08
0.14
1.8
1.5
—
—
—
0
0
24
264
0.91
0.14
1.7
1.5
—
—
—
0
0
23
208
1.11
0.14
1.7
1.5
0.3
0.4
nmol/l
0.64
17
174
9
110
0.82
0.13
1.2
1.8
—
—
—
0
0
24
220
1.09
0.12
1.5
1.5
106.6
100.9
u/ml
—
7
45
11
95
1.16
0.11
1.2
1.7
—
—
—
0
0
16
178
0.90
0.11
1.1
1.1
—
—
—
0
0
40
377
1.06
0.11
1.6
1.7
—
—
—
0
0
5
47
1.06
0.09
1.0
1.7
—
73.1
—
0
7
258
2621
0.98
0.09
1.6
1.7
1.3
1.4
mmol/l
0.62
226
2249
6
56
1.07
0.08
1.8
1.7
—
—
—
0
0
6
56
1.07
0.08
1.8
1.7
—
—
—
0
0
6
56
1.07
0.08
1.8
1.7
—
—
—
0
0
6
56
1.07
0.08
1.3
1.2
—
—
—
0
0
6
56
1.07
0.08
1.8
1.7
—
—
—
0
0
16
175
0.91
0.08
1.1
1.2
—
—
—
0
0
5
63
0.79
0.08
2.0
2.0
—
—
—
0
0
40
381
1.05
0.08
2.6
3.3
25.4
25.1
mmol/l
0.25
40
369
10
88
1.14
0.08
1.5
2.1
421.4
760.0
e6/l
—
5
34
15
164
0.91
0.08
1.1
1.1
—
—
—
0
0
6
73
0.82
0.07
1.0
1.9
—
—
—
0
0
7
81
0.86
0.07
1.1
1.3
—
—
—
0
0
21
196
1.07
0.07
1.3
1.4
27.1
21.0
u/l
0.24
14
169
9
85
1.06
0.07
1.2
1.1
—
—
—
0
0
9
85
1.06
0.07
1.2
1.1
—
—
—
0
0
9
86
1.05
0.07
1.2
1.1
—
—
—
0
0
9
86
1.05
0.07
1.2
1.1
—
—
—
0
0
9
86
1.05
0.07
1.2
1.1
—
—
—
0
0
18
167
1.08
0.07
1.1
1.1
—
—
—
0
0
8
94
0.85
0.06
1.0
1.6
9.7
12.0
umol/l
—
8
87
28
293
0.95
0.05
1.1
1.2
—
—
—
0
0
28
292
0.96
0.04
1.1
1.2
—
—
—
0
0
12
111
1.08
0.04
2.5
3.1
0.9
0.9
nmol/l
0.07
12
86
26
250
1.04
0.03
1.5
1.3
184.6
239.9
u/ml
0.74
19
157
11
103
1.07
0.02
1.7
1.7
—
—
—
0
0
45
442
1.02
0.01
1.3
1.3
219.7
220.8
miu/ml
0.01
23
217
18
187
0.96
0.01
1.2
1.2
1.4
4.3
u/ml
—
5
59
10
104
0.96
0.00
1.1
1.0
—
—
—
0
0
16
156
1.03
0.00
1.4
1.2
—
—
—
0
0
20
202
0.99
0.00
2.9
3.4
27.4
26.7
mg/l
—
8
121
23
228
1.01
0.00
1.5
1.4
858.6
908.6
e6/l
0.02
18
183
23
228
1.01
0.00
1.4
1.4
12.8
10.8
e6/l
0.07
16
177
10
103
0.97
0.00
1.1
1.4
16.0
12.9
mmol/l
—
5
27
27
265
1.02
0.00
1.4
1.2
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
26
255
1.02
0.00
3.7
3.7
0.4
0.4
u/ml
0.21
17
138
20
195
1.03
0.00
1.8
1.5
—
—
—
0
0
11
115
0.96
0.00
1.7
1.7
—
—
—
0
0
17
175
0.97
0.00
1.4
1.4
—
—
—
0
0
13
135
0.96
0.00
1.2
1.1
101.0
95.3
%
0.31
13
126
0
9
0.00
0.00
0.0
1.2
—
7.6
—
0
9
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
31
310
1.00
0.00
6.7
4.1
1.4
1.4
mmol/l
0.13
31
302
0
5
0.00
0.00
0.0
2.6
—
15.5
—
0
5
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
6
61
0.98
0.00
3.7
8.0
—
60.2
u/ml
—
0
23
0
8
0.00
0.00
0.0
7.8
—
—
—
0
0
7
77
0.91
0.00
1.7
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
6.8
—
—
—
0
0
0
5
0.00
0.00
0.0
5.4
—
—
—
0
0
9
93
0.97
0.00
1.0
1.3
—
—
—
0
0
5
57
0.88
0.00
1.2
1.2
—
—
—
0
0
9
94
0.96
0.00
1.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
4.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
59
0.85
0.00
1.0
1.3
27.8
35.6
nmol/l
—
5
47
0
6
0.00
0.00
0.0
1.0
—
65.7
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
5.3
—
420.7
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_BONE_LONG_LOWER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_BONE_LONG_LOWER | 1.158 [0.95, 1.41] | 0.149 |
| Birth year | 0.994 [0.99, 1.0] | 0.166 |
During the follow-up period (1.1.1998 — 31.12.2019), 134 out of 2886 females with CD2_BENIGN_BONE_LONG_LOWER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_BONE_LONG_LOWER | 1.061 [0.88, 1.28] | 0.529 |
| Birth year | 0.985 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 164 out of 3257 males with CD2_BENIGN_BONE_LONG_LOWER died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_BONE_LONG_LOWER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.124% | 0.179% |
| 5 | 0.617% | 1.067% |
| 10 | 1.529% | 2.808% |
| 15 | 3.177% | 5.416% |
| 20 | 5.471% | 9.13% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_BONE_LONG_LOWER – Benign neoplasm: Long bones of lower limb
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data