Benign neoplasm: Long bones of lower limb

CD2_BENIGN_BONE_LONG_LOWER

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D16.2&
  • Hospital discharge: ICD-9 2137
  • Hospital discharge: ICD-8 21306
  • Cause of death: ICD-10 D16.2&
  • Cause of death: ICD-9 2137
  • Cause of death: ICD-8 21306

2 out of 7 registries used, show all original rules.

1305

4. Check minimum number of events

None

1305

5. Include endpoints

None

1305

6. Filter based on genotype QC (FinnGen only)

1271

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D16
Name in latin
Neoplasma benignum ossium longorum membri inferioris

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 10196 4557 5600
Only index persons 9666 4381 5285
Unadjusted period prevalence (%)
Whole population 0.14 0.13 0.16
Only index persons 0.18 0.16 0.20
Median age at first event (years)
Whole population 23.26 27.03 20.08
Only index persons 23.02 26.68 19.98

-FinnGen-

Key figures

All Female Male
Number of individuals 1271 727 544
Unadjusted period prevalence (%) 0.25 0.26 0.25
Median age at first event (years) 36.67 37.86 35.09

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1305
Matched controls
13050
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D16.2
ICD-10 Finland
Benign neoplasm: Long bones of lower limb
13475.6
307.7
942
*
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
60.4
307.7
242
49
9102
FHL
Trepanation or removal of the local bone process
99.4
258.0
134
15
21306
ICD-8 Finland
Benign neoplasm of bone and cartilage, Ossium longorum extremitatis inferioris
+∞
223.5
208
*
2137A
ICD-9 Finland
Benign neoplasm of bone and articular cartilage, Long bones of lower limb
+∞
187.1
175
*
NFR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of hip or thigh
69.9
155.8
85
13
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
11.0
116.8
130
130
NGR20
NOMESCO Finland
Intralesional or marginal excision of tumor of knee or lower leg
218.0
116.7
119
6
NF3AA
NOMESCO Finland
Femur X-ray examination
10.7
68.4
76
75
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
9.4
67.3
82
92
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
3.5
58.2
233
765
NK6CT
NOMESCO Finland
Bone biopsy with CT guidance
59.5
39.5
46
8
NG4AA
NOMESCO Finland
Lower leg X-ray examination
5.0
38.3
85
179
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
4.0
34.5
103
274
NFK10
NOMESCO Finland
Fenestration or partial or total excision of bone of femur
298.3
28.9
29
*
NK6BN
NOMESCO Finland
Bone dynamic isotope examination
31.7
28.2
37
12
NF1AA
NOMESCO Finland
Hip X-ray examination
3.0
26.6
123
433
M79.6
ICD-10 Finland
Pain in limb
1.9
25.9
570
3830
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
4.3
25.0
66
160
NG1DG
NOMESCO Finland
Knee and lower leg very extensive MRI examination with high intensity magnet
26.8
24.9
34
13
NHR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of ankle or foot
49.4
24.3
29
6
M17.1
ICD-10 Finland
Other primary gonarthrosis
2.1
23.8
260
1367
NGK05
NOMESCO Finland
Partial or total excision of bone of lower leg
88.4
23.7
26
*
D16.3
ICD-10 Finland
Benign neoplasm: Short bones of lower limb
81.5
21.7
24
*
NE1DG
NOMESCO Finland
Pelvic, hip and femur very extensive MRI examination with high intensity magnet
9.1
21.2
26
29
C40.22
ICD-10 Finland
Chondrosarcoma of the long bones of the lower extremity
203.0
19.6
20
*
D16.0
ICD-10 Finland
Benign neoplasm: Scapula and long bones of upper limb
40.8
19.5
24
6
9101
FHL
Bone biopsy
40.8
19.5
24
6
ZZH40
NOMESCO Finland
Substitute of bone
7.6
19.1
27
36
WX320
NOMESCO Finland
Spinalanesthesy
1.8
17.4
302
1842
M25.5
ICD-10 Finland
Pain in joint
1.7
16.6
436
2989
D16.1
ICD-10 Finland
Benign neoplasm: Short bones of upper limb
20.3
16.4
24
12
NG1AD
NOMESCO Finland
Knee CT examination
4.6
15.0
35
77
D48.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Connective and other soft tissue
4.1
14.1
38
94
ZXA05
NOMESCO Finland
Left side
1.7
13.8
274
1726
NGR30
NOMESCO Finland
Extensive or radikal excision of tumor of knee or lower leg
141.4
13.5
14
*
C40.20
ICD-10 Finland
Malignant tumor of the long bones of the lower extremity without histology
141.4
13.5
14
*
N03AX16
ATC
[U] pregabalin
1.7
13.5
283
1811
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
13.5
556
4203
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
13.4
471
3428
L15
ICPC
Knee symptom/complaint
1.7
12.9
291
1894
Q78.6
ICD-10 Finland
Multiple congenital exostoses
50.5
12.9
15
*
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
2.5
12.7
83
349
N02AX02
ATC
tramadol; systemic, rectal
1.6
12.6
499
3723
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.6
12.5
347
2380
9220/3-C40.2
ICD-O-3
Chondrosarcoma, NOS, of long bones of lower limb and associated joints
+∞
12.5
12
*
N02AJ06
ATC
codeine and paracetamol; systemic
1.5
12.5
539
4095
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
2.0
12.4
149
801
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
12.1
505
3802
R22.4
ICD-10 Finland
Localized swelling, mass and lump, lower limb
3.4
12.0
43
130
NFK99
NOMESCO Finland
Other operation on bone of femur
47.1
11.9
14
*
9104
FHL
Autogenous bone graft
65.5
11.6
13
*
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
2.0
11.4
131
693
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.1
11.3
110
548
NFR30
NOMESCO Finland
Extended excision of soft tissue tumour of hip or thigh
35.3
11.3
14
*
N06AX21
ATC
duloxetine; oral
1.9
11.2
161
917
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
3.9
11.2
33
87
N02BE01
ATC
paracetamol; systemic, rectal
1.7
11.2
1111
10016
X58
ICD-10 Finland
Exposure to other specified factors
1.7
10.6
203
1259
9103
FHL
Partial or complete bone removal
14.3
10.5
17
12
NFA20
NOMESCO Finland
Exploration of hip joint or femur
110.9
10.4
11
*
NFR99
NOMESCO Finland
Other operation for tumour of hip or thigh
+∞
10.4
10
*
M85.4
ICD-10 Finland
Solitary bone cyst
16.2
10.4
16
10
M54.5
ICD-10 Finland
Low back pain
1.5
10.1
451
3410
M16.1
ICD-10 Finland
Other primary coxarthrosis
2.0
9.9
116
617
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
2.8
9.9
50
185
M01AE02
ATC
naproxen; oral, rectal
1.5
9.9
718
5960
M01AH05
ATC
etoricoxib; oral
1.5
9.9
771
6488
NFU20
NOMESCO Finland
Removal of internal fixation device from femur
5.2
9.9
20
39
D16.90
ICD-10 Finland
Bone and articular cartilage, unspecified
26.2
9.8
13
5
D16.8
ICD-10 Finland
Benign neoplasm: Pelvic bones, sacrum and coccyx
20.2
9.8
14
7
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.6
9.8
312
2195
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
3.6
9.5
31
88
C40.2
ICD-10 Finland
Malignant neoplasm: Long bones of lower limb
100.7
9.4
10
*
M12.2
ICD-10 Finland
Villonodular synovitis (pigmented)
30.2
9.4
12
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
9.4
302
2128
D21.2
ICD-10 Finland
Benign neoplasm: Connective and other soft tissue of lower limb, including hip
13.8
9.2
15
11
M01AE01
ATC
ibuprofen; systemic, rectal
1.8
9.1
1177
10915
B01AB05
ATC
enoxaparin; parenteral
1.5
9.1
329
2376
SPAT1153
SPAT
Removal of sutures
1.5
8.8
337
2457
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.6
8.8
211
1386
M22.4
ICD-10 Finland
Chondromalacia patellae
2.6
8.6
49
193
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.8
8.6
124
707
NH1BG
NOMESCO Finland
Ankle and foot MRI examination with high intensity magnet
3.2
8.5
33
105
NGK99
NOMESCO Finland
Other operation on bone of knee or lower leg
20.2
8.5
12
6
C40.21
ICD-10 Finland
Osteosarcoma of the long bones of the lower extremity
90.6
8.4
9
*
D48.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Neoplasm of uncertain or unknown behaviour, unspecified
3.4
8.4
29
86
C40.29
ICD-10 Finland
Malignant tumor of the long bones of the lower extremity other or unspecified histology
+∞
8.3
8
*
J01AA02
ATC
doxycycline; systemic
1.4
7.9
913
8080
NG4AD
NOMESCO Finland
Lower leg CT
13.1
7.9
13
10
ZXE10
NOMESCO Finland
More than one and less than three hours
1.4
7.7
390
2991
9180/3-C40.2
ICD-O-3
Osteosarcoma, NOS, of long bones of lower limb and associated joints
45.2
7.7
9
*
NK6DT
NOMESCO Finland
Bone biopsy with MRI guidance
45.2
7.7
9
*
M01AB05
ATC
diclofenac; systemic, rectal
1.4
7.7
796
6897
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
7.6
660
5546
SPAT1312
SPAT
General health counselling
1.4
7.6
375
2862
NGA20
NOMESCO Finland
Exploration of soft tissue knee or lower leg, open
11.9
7.6
13
11
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
2.1
7.5
66
317
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.8
7.5
108
617
M85.0
ICD-10 Finland
Fibrous dysplasia (monostotic)
80.5
7.4
8
*
NER20
NOMESCO Finland
Incomplete excision of soft tissue tumour of pelvis
80.5
7.4
8
*
NF3BA
NOMESCO Finland
Femur extensive X-ray examination
13.4
7.4
12
9
NBR20
NOMESCO Finland
Intralesional or marginal excision of soft tissue tumour of shoulder or upper arm
13.4
7.4
12
9
M03BX02
ATC
tizanidine; oral
1.4
7.3
761
6572
NGR99
NOMESCO Finland
Other operation for tumour of knee or lower leg
+∞
7.3
7
*
Q78.1
ICD-10 Finland
Polyostotic fibrous dysplasia
+∞
7.3
7
*
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.0
7.3
79
410
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.6
7.3
209
1429
NH1CG
NOMESCO Finland
Ankle and foot extensive MRI examination with high intensity magnet
3.6
7.2
23
65
S18
ICPC
Laceration/cut
1.4
7.2
502
4063
X59
ICD-10 Finland
Exposure to unspecified factor
1.5
7.2
229
1603
S83.6
ICD-10 Finland
Sprain and strain of other and unspecified parts of knee
2.0
7.1
75
385
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.1
7.1
70
351
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.0
7.1
72
365
ZXD10
NOMESCO Finland
Scheduled procedure
1.4
7.1
410
3211
M23.8
ICD-10 Finland
Other internal derangements of knee
2.3
7.1
50
219
2392A
ICD-9 Finland
Neoplasm of unspecified nature, Bone, soft tissue and skin
12.1
7.1
12
10
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
1.7
7.0
125
758
A02BC02
ATC
pantoprazole; systemic
1.4
7.0
766
6645
AA1AD
NOMESCO Finland
CT of head and brain
1.5
7.0
259
1868
UKC02
NOMESCO Finland
Cystoscopy
1.7
6.9
142
895
J01FF01
ATC
clindamycin; systemic
1.4
6.9
302
2249
M02AA07
ATC
piroxicam; topical
1.4
6.8
359
2766
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.7
6.8
122
743
D16
ICD-10 Finland
Benign neoplasm of bone and articular cartilage
40.3
6.8
8
*
M01AE03
ATC
ketoprofen; systemic, rectal
1.4
6.7
387
3023
S93.4
ICD-10 Finland
Sprain and strain of ankle
1.6
6.7
155
1006
L16
ICPC
Ankle symptom/complaint
1.7
6.7
137
864
NG1BG, ,
SPAT
2.1
6.7
60
291
NJ3NA
NOMESCO Finland
Measurement of difference in extremity lengty with X-ray
3.6
6.6
21
59
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.4
6.6
282
2091
NF1BA
NOMESCO Finland
Hip extensive X-ray examination
2.6
6.6
37
146
NB1BA
NOMESCO Finland
Shoulder extensive X-ray examination without contrast
2.5
6.6
38
152
NG1AA, ,
SPAT
1.8
6.6
92
521
S83.4
ICD-10 Finland
Sprain and strain involving (fibular)(tibial) collateral ligament of knee
2.3
6.5
48
215
NG1BA
NOMESCO Finland
Knee extensive X-ray examination
2.8
6.4
30
107
SFA30
NOMESCO Finland
Three-surface restoration
1.4
6.4
498
4077
NJ3DG
NOMESCO Finland
Very extensive MRI examination of extremities with high intensity magnet
70.2
6.4
7
*
NH1BA
NOMESCO Finland
Ankle extensive X-ray examination
2.6
6.4
36
142
Q78.48
ICD-10 Finland
Enchondromatosis
+∞
6.3
6
*
M93.8
ICD-10 Finland
Other specified osteochondropathies
+∞
6.3
6
*
S83.2
ICD-10 Finland
Tear of meniscus, current
1.8
6.2
85
477
M84.4
ICD-10 Finland
Pathological fracture, not elsewhere classified
26.8
6.2
8
*
NDR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of wrist or hand
3.7
6.2
19
52
M03BC01
ATC
orphenadrine (citrate); systemic
1.4
6.2
275
2052
Z47.8
ICD-10 Finland
Other specified orthopaedic follow-up care
5.8
6.1
16
28
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.6
6.1
142
923
J01DB01
ATC
cefalexin; oral
1.4
6.0
1025
9418

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
895
7670
1.53
11.15
4.6
3.8
9.81
10.45
mm/h
0.82
827
7152
191
1162
1.75
10.70
4.1
4.0
31.92
31.39
%
0.25
131
830
527
4127
1.46
9.85
2.0
2.0
—
—
—
0
0
530
4188
1.45
9.30
11.1
11.7
1.18
1.19
inr
0.07
133
1297
601
4861
1.44
9.29
2.6
2.5
—
—
—
0
0
894
7807
1.46
8.95
8.0
7.3
78.10
76.61
u/l
0.43
842
7381
570
4628
1.41
8.33
7.7
6.7
1.21
1.21
mmol/l
0.02
472
3971
146
889
1.72
8.10
4.0
4.0
—
—
—
0
0
325
2410
1.46
7.69
2.3
2.2
—
—
—
0
0
410
3176
1.42
7.67
2.4
2.2
—
—
—
0
0
1158
10806
1.64
7.28
14.2
12.3
20.45
22.25
mg/l
1.19
921
8403
347
2637
1.43
7.13
4.0
3.4
—
—
—
0
0
512
4172
1.37
6.95
6.9
6.1
1.21
1.21
mmol/l
0.23
458
3838
217
1518
1.52
6.78
1.4
1.3
420.00
492.27
titre
0.33
44
313
364
2823
1.40
6.59
2.3
2.1
269.80
221.75
u/l
0.20
349
2674
50
232
2.20
6.22
1.4
1.8
20349.38
12229.04
e6/l
0.48
39
171
490
4018
1.35
6.21
4.8
4.9
36.46
36.31
g/l
0.26
442
3768
757
6655
1.33
5.81
4.6
4.0
117.33
1856.26
e6/l
—
6
89
22
70
3.18
5.75
3.3
2.8
47909.09
40592.11
ug/l
0.75
22
70
673
5829
1.32
5.69
4.9
4.8
6.51
6.59
mmol/l
0.48
632
5413
803
7140
1.32
5.58
4.5
4.0
—
—
—
0
0
602
5179
1.30
5.16
6.1
6.2
10.88
11.10
umol/l
0.12
569
4907
193
1411
1.43
4.77
2.3
2.0
—
—
—
0
0
430
3572
1.30
4.68
3.3
3.2
21.91
43.33
ng/l
2.52
269
2195
579
5012
1.28
4.54
6.8
6.2
—
—
—
0
0
36
168
2.18
4.50
1.5
1.7
—
—
—
0
0
380
3121
1.31
4.46
2.6
2.6
54.43
58.54
u/l
1.08
341
2903
902
8267
1.29
4.40
4.2
3.9
14.72
14.58
pmol/l
1.02
828
7614
14
34
4.15
4.21
3.4
1.9
81.50
69.19
ug/l
0.18
14
34
129
894
1.49
4.21
2.7
2.3
0.22
0.22
g/l
0.11
124
836
121
828
1.51
4.20
3.5
4.5
36.54
24.29
ug/l
0.14
97
674
1139
10820
1.41
4.19
15.8
13.4
139.67
139.65
mmol/l
0.13
1107
10533
172
1261
1.42
4.19
1.2
1.3
—
—
—
0
0
320
2587
1.31
4.18
2.7
2.5
3224.29
5346.56
umol/l
0.46
287
2312
112
757
1.52
4.12
3.4
3.3
—
—
—
0
0
122
844
1.49
4.02
2.6
2.7
10.18
10.41
g/l
0.29
115
774
1140
10857
1.40
3.89
15.8
13.5
3.94
3.95
mmol/l
0.21
1105
10548
98
660
1.52
3.69
3.3
4.1
69.58
82.73
ng/l
0.91
88
597
376
3155
1.27
3.62
3.0
3.3
2.35
2.36
mmol/l
0.12
331
2837
599
5301
1.24
3.61
6.5
5.8
0.04
0.04
e9/l
0.16
521
4648
597
5290
1.24
3.53
6.5
5.8
0.56
0.57
e9/l
0.17
518
4639
616
5492
1.23
3.39
6.9
6.1
0.19
0.19
e9/l
0.15
543
4873
95
655
1.49
3.23
2.2
2.8
67.52
67.31
g/l
0.12
88
604
670
6046
1.22
3.22
9.5
8.9
3.98
4.04
e9/l
0.25
595
5313
228
1821
1.31
3.21
1.4
1.2
7.30
10.46
u/ml
0.53
94
738
66
421
1.60
3.18
1.4
1.2
—
—
—
0
0
612
5479
1.22
3.16
6.5
5.8
1.97
1.99
e9/l
0.10
548
4915
823
7598
1.23
3.10
3.6
3.1
47.43
46.65
u/l
0.10
765
7192
96
671
1.46
3.06
1.7
1.7
1.12
1.34
g/l
1.29
90
615
235
1904
1.29
2.96
1.4
1.3
21.59
29.60
iu/ml
0.81
80
611
48
288
1.69
2.95
1.4
1.2
3.66
11.15
u/ml
—
9
52
158
1219
1.34
2.84
1.7
1.6
—
—
—
0
0
275
2285
1.26
2.81
2.9
3.0
1079.77
1069.57
ng/l
0.01
226
1903
51
316
1.64
2.79
2.1
2.3
557.33
317.26
ug/l
0.27
46
294
21
98
2.16
2.71
1.2
1.4
15062.00
180565.00
e6/l
1.05
11
73
25
126
2.00
2.66
1.4
1.3
—
—
—
0
0
539
4826
1.20
2.64
6.7
6.0
0.71
0.68
%
1.01
496
4530
1033
9841
1.24
2.54
5.0
4.5
1.77
2.08
mu/l
1.13
952
9160
46
286
1.63
2.51
1.5
1.2
2.48
2.74
u/ml
—
6
32
157
1233
1.31
2.51
6.6
6.0
1.04
1.04
mmol/l
0.01
149
1151
79
556
1.45
2.47
1.8
2.3
—
—
—
0
0
23
116
2.00
2.46
1.6
1.7
48.31
57.76
%
0.51
16
84
555
5005
1.19
2.46
6.7
5.9
2.89
2.84
%
0.22
516
4708
1181
11444
1.34
2.46
13.9
11.4
—
—
—
0
0
30
166
1.83
2.46
1.6
1.8
—
—
—
0
0
558
5037
1.19
2.44
7.1
6.2
8.47
8.40
%
0.23
519
4754
320
2751
1.22
2.37
3.0
2.7
—
—
—
0
0
19
91
2.10
2.33
1.2
1.1
—
—
—
0
0
215
1776
1.25
2.31
2.9
3.5
457.41
514.39
ng/l
0.07
137
1240
232
1933
1.24
2.31
1.6
1.6
414.86
36232307.39
pmol/l
2.15
192
1656
27
148
1.84
2.29
1.3
1.4
—
—
—
0
0
470
4202
1.19
2.26
2.6
2.3
77.14
74.53
nmol/l
0.79
421
3828
1064
10203
1.23
2.25
4.5
4.0
5.81
5.85
mmol/l
0.47
967
9441
566
5146
1.18
2.21
6.7
5.7
55.82
56.69
%
1.03
528
4863
21
107
1.98
2.21
1.9
1.4
2.50
2.72
g/l
0.27
11
73
21
107
1.98
2.21
1.9
1.4
0.27
0.31
g/l
0.28
11
74
21
107
1.98
2.21
1.9
1.4
5.61
6.99
g/l
0.96
11
75
83
604
1.40
2.19
1.2
1.2
—
—
—
0
0
100
751
1.36
2.19
3.6
2.9
4.41
6.05
e9/l
0.80
75
643
15
67
2.25
2.18
1.7
2.0
—
—
—
0
0
45
290
1.57
2.16
1.5
1.5
254.30
290.28
ug/g
0.57
25
171
423
3761
1.18
2.15
1.9
1.8
102.78
96.16
pmol/l
1.55
224
2015
301
2596
1.21
2.14
1.9
1.9
—
—
—
0
0
88
651
1.38
2.12
2.4
2.8
70.13
73.15
e9/l
0.34
66
495
571
5210
1.17
2.11
6.9
5.9
29.51
28.76
%
0.92
534
4928
21
109
1.94
2.11
1.2
1.7
23.24
21.72
nmol/l
0.16
21
103
5
10
5.01
2.07
1.2
1.3
—
—
—
0
0
13
56
2.33
2.05
1.4
3.0
773.69
1000.70
u/ml
0.34
13
56
296
2560
1.20
2.04
3.9
3.8
92.80
93.46
%
0.19
289
2487
182
1497
1.25
2.04
1.7
1.6
—
—
—
0
0
117
912
1.31
2.01
2.1
2.2
13.98
13.09
nmol/l
0.53
104
832
568
5195
1.17
2.01
3.8
3.3
0.00
0.01
estimate
0.80
104
942
284
2456
1.20
1.96
4.3
4.1
—
—
—
0
0
995
9521
1.19
1.94
5.7
5.0
38.63
39.00
mmol/mol
0.73
923
8939
90
681
1.35
1.91
2.9
3.3
4.52
4.60
pmol/l
0.38
78
606
49
333
1.49
1.89
2.4
1.5
0.21
0.24
g/l
1.34
44
314
66
476
1.41
1.87
1.1
1.1
—
—
—
0
0
33
205
1.63
1.87
4.1
3.0
—
—
—
0
0
42
277
1.53
1.86
1.5
1.2
—
—
—
0
0
560
5141
1.16
1.84
5.0
4.5
0.00
0.00
estimate
0.50
104
989
122
969
1.29
1.84
1.5
1.5
—
—
—
0
0
20
108
1.87
1.82
2.1
1.4
—
—
—
0
0
560
5146
1.15
1.81
3.8
3.3
0.00
0.00
estimate
0.50
104
1022
270
2341
1.19
1.81
1.6
1.4
2.16
2.30
g/l
0.77
182
1480
22
123
1.80
1.80
1.4
1.2
—
—
—
0
0
30
184
1.65
1.79
2.3
1.7
1.02
0.82
g/l
0.36
19
139
463
4202
1.16
1.76
3.4
3.1
5.92
5.83
ph
0.25
49
392
46
314
1.48
1.75
1.2
1.2
47.14
94.19
titre
—
7
31
63
457
1.40
1.75
4.2
2.8
—
—
—
0
0
6
18
3.34
1.74
1.2
1.1
5.12
5.74
nmol/l
—
6
18
5
13
3.86
1.71
1.2
1.2
—
—
—
0
0
11
48
2.30
1.70
1.0
1.5
—
—
—
0
0
1246
12247
1.38
1.67
21.7
17.9
40.77
41.11
%
0.38
1196
11567
173
1449
1.22
1.66
1.8
2.2
30.11
29.55
s
0.35
164
1404
1248
12271
1.39
1.66
21.5
17.9
136.70
137.26
g/l
0.74
1236
12113
17
90
1.90
1.65
1.5
2.8
—
—
—
0
0
1246
12252
1.38
1.62
21.6
17.8
256.52
254.39
e9/l
0.59
1224
11965
240
2080
1.19
1.62
1.5
1.5
19.96
20.74
nmol/l
0.34
200
1794
303
2678
1.17
1.62
1.3
1.3
0.94
1.62
u/ml
1.36
80
722
1247
12264
1.38
1.61
21.4
17.7
90.45
90.43
fl
0.08
1235
12110
334
2976
1.16
1.61
4.7
4.2
1.89
2.04
ug/l
0.30
303
2713
93
727
1.30
1.61
4.2
3.7
1.22
1.23
mmol/l
0.88
80
638
1247
12265
1.38
1.60
21.4
17.7
30.21
30.21
pg
0.05
1235
12110
8
32
2.51
1.60
1.6
3.5
—
—
—
0
0
1247
12266
1.37
1.59
21.5
17.8
4.55
4.57
e12/l
0.74
1224
11965
308
2730
1.17
1.58
4.5
3.9
7.40
7.40
ph
0.20
62
527
7
26
2.70
1.58
1.0
1.4
—
—
—
0
0
1247
12267
1.37
1.58
21.5
17.8
6.71
6.68
e9/l
0.18
1223
11957
90
704
1.30
1.56
1.3
1.4
—
—
—
0
0
173
1461
1.21
1.54
2.3
2.4
85.55
113.02
ug/g
0.69
133
1164
18
100
1.81
1.53
1.1
1.1
27.44
42.27
mg/l
1.95
18
78
116
940
1.26
1.52
1.2
1.2
—
—
—
0
0
272
2395
1.17
1.52
1.9
1.8
1.03
1.01
mg/l
0.06
208
1774
305
2710
1.16
1.52
4.4
3.6
0.00
0.01
estimate
1.28
101
961
229
1990
1.18
1.50
2.6
2.5
6.68
6.07
e6/l
0.23
202
1795
337
3025
1.15
1.46
3.7
3.2
8.07
8.15
mmol/l
0.09
287
2615
220
1910
1.18
1.46
3.1
2.6
585.37
548.20
mosm/kgh2o
1.52
183
1663
33
220
1.51
1.44
1.0
1.4
—
—
—
0
0
17
95
1.80
1.43
1.0
1.1
225.82
257.30
mg/l
0.56
17
82
45
321
1.42
1.41
1.2
1.2
—
881.25
titre
—
0
8
78
609
1.30
1.39
2.5
2.3
3702.32
4243.40
u/l
0.09
22
253
14
74
1.90
1.39
1.1
1.0
—
—
—
0
0
178
1525
1.19
1.38
4.5
3.5
0.83
0.82
mmol/l
0.44
164
1447
12
60
2.01
1.38
1.3
1.3
—
—
—
0
0
25
158
1.59
1.38
1.5
2.0
—
1330.00
—
0
8
5
122
0.41
1.37
1.0
1.1
—
—
—
0
0
81
637
1.29
1.37
1.5
1.4
22.15
24.62
iu/l
0.28
71
532
104
844
1.25
1.37
1.3
1.2
92.06
145.21
iu/ml
1.29
41
338
20
322
0.62
1.36
1.3
1.5
—
—
—
0
0
524
4869
1.13
1.33
2.9
2.8
114.49
109.22
ug/l
0.25
494
4543
176
1513
1.19
1.32
1.7
1.7
1144.64
1173.02
nmol/l
0.17
130
1170
118
976
1.23
1.32
10.2
9.4
1.22
1.14
mmol/l
0.10
96
789
112
922
1.23
1.31
2.8
2.8
1.76
1.76
%
0.02
102
836
21
129
1.64
1.30
1.3
1.2
—
—
—
0
0
95
769
1.25
1.29
4.1
4.2
0.53
0.64
%
0.27
37
244
43
311
1.40
1.27
6.4
3.6
1.32
1.41
mg/l
0.38
38
289
294
2640
1.15
1.27
3.2
2.9
0.33
0.38
e6/l
0.26
232
1999
118
981
1.22
1.26
10.2
9.3
5.08
5.13
kpa
0.23
111
938
118
981
1.22
1.26
10.2
9.3
12.57
12.56
kpa
0.01
111
942
20
315
0.63
1.26
1.4
1.4
—
—
—
0
0
78
619
1.28
1.25
3.3
2.2
—
—
—
0
0
1100
10719
1.17
1.25
4.7
4.4
2.84
2.83
mmol/l
0.18
1020
10042
59
451
1.32
1.24
1.4
1.2
—
—
—
0
0
290
2606
1.15
1.24
3.1
2.9
—
—
—
0
0
17
100
1.71
1.23
2.9
2.5
1.10
1.47
g/24h
—
10
57
20
313
0.63
1.23
1.3
1.4
—
—
—
0
0
8
37
2.17
1.21
1.3
1.4
46.53
80.47
nmol/24h
—
8
37
139
1180
1.20
1.21
1.4
1.4
—
—
—
0
0
106
876
1.23
1.21
10.9
10.0
96.65
96.06
%
0.93
100
846
61
471
1.31
1.21
11.1
12.9
—
—
—
0
0
76
605
1.27
1.20
4.0
3.3
7.41
7.41
ph
0.03
12
80
8
38
2.11
1.18
2.0
2.0
—
—
—
0
0
12
64
1.88
1.18
1.4
1.4
—
—
—
0
0
82
662
1.25
1.16
3.2
2.2
—
—
—
0
0
13
72
1.81
1.15
1.1
1.0
—
—
—
0
0
82
665
1.25
1.12
3.2
2.1
—
—
—
0
0
101
839
1.22
1.11
4.4
4.4
0.95
0.98
%
0.03
37
291
66
522
1.28
1.11
3.6
2.2
—
—
—
0
0
5
21
2.39
1.09
1.0
1.1
—
—
—
0
0
5
21
2.39
1.09
1.0
1.1
—
—
—
0
0
5
21
2.39
1.09
1.0
1.1
—
—
—
0
0
80
653
1.24
1.05
1.7
2.0
—
—
—
0
0
55
429
1.29
1.04
2.2
2.2
—
—
—
0
0
136
1171
1.18
1.03
1.4
1.3
—
—
—
0
0
21
138
1.53
1.03
1.8
1.6
—
—
—
0
0
1042
10154
1.13
1.01
4.0
3.6
1.27
1.31
mmol/l
1.34
960
9499
1172
11513
1.18
1.01
11.4
9.5
28.36
27.46
u/l
0.80
1134
11165
56
440
1.28
1.01
4.7
3.4
—
—
—
0
0
32
231
1.39
1.00
1.8
2.3
0.95
0.85
nmol/l
0.25
26
201
116
989
1.19
0.99
2.0
2.1
345.81
372.07
nmol/l
0.89
106
921
39
292
1.35
0.98
7.4
7.9
1.15
1.23
mmol/l
0.41
33
252
28
198
1.42
0.98
9.0
9.7
106.00
105.39
mmol/l
0.38
23
178
28
198
1.42
0.98
9.0
9.7
10.48
11.07
mmol/l
0.54
23
178
25
173
1.45
0.98
2.7
2.3
5.74
4.78
umol/l
0.32
14
126
180
1594
1.15
0.97
2.8
2.6
0.80
1.09
e6/l
1.04
107
898
10
54
1.86
0.96
1.3
1.3
—
—
—
0
0
96
808
1.20
0.95
1.4
1.4
—
—
—
0
0
14
85
1.65
0.94
1.6
2.3
—
—
—
0
0
69
562
1.24
0.94
7.2
5.8
—
—
—
0
0
26
183
1.43
0.94
1.6
3.9
—
—
—
0
0
42
321
1.32
0.94
2.3
2.5
—
—
—
0
0
15
233
0.64
0.93
2.5
2.3
128.74
129.74
ug/min
—
9
141
9
52
1.74
0.92
1.3
1.6
—
—
—
0
0
155
1364
1.15
0.92
2.4
2.3
2.41
2.38
g/l
0.30
146
1260
29
210
1.39
0.91
4.4
3.7
1.71
2.35
mmol/l
0.90
22
134
1077
10536
1.13
0.90
4.4
4.0
1.44
1.45
mmol/l
0.36
996
9886
35
262
1.35
0.90
1.1
1.1
4.19
3.09
u/ml
0.13
18
144
53
421
1.27
0.90
1.6
1.6
—
—
—
0
0
45
350
1.30
0.90
4.4
3.7
0.23
0.27
g/l
0.23
29
157
94
797
1.19
0.88
4.4
4.5
0.10
0.14
%
0.28
30
247
16
103
1.56
0.87
2.4
3.8
—
—
—
0
0
90
761
1.20
0.87
4.6
4.6
0.11
0.56
%
0.53
28
208
313
2890
1.11
0.86
3.2
3.1
29.04
77.20
e6/l
1.29
246
2221
11
64
1.72
0.86
1.4
1.2
—
—
—
0
0
169
1505
1.14
0.85
2.9
2.7
2.42
2.56
e6/l
0.11
100
814
143
1260
1.15
0.84
2.5
2.4
25.54
23.86
%
0.60
123
1086
33
248
1.34
0.84
1.0
1.1
—
—
—
0
0
154
1365
1.15
0.84
1.3
1.2
—
—
—
0
0
45
354
1.28
0.84
6.7
6.8
2.39
1.58
%
0.69
40
330
299
2760
1.11
0.83
3.9
3.9
6.21
9.73
mg/mmol
1.41
189
1795
8
46
1.74
0.82
1.0
1.1
—
14.01
—
0
11
8
46
1.74
0.82
1.1
1.1
1659.25
1547.48
miu/ml
—
8
46
25
180
1.40
0.82
1.4
1.5
—
—
—
0
0
78
655
1.20
0.82
3.3
2.2
—
—
—
0
0
24
172
1.40
0.81
2.0
1.7
—
—
—
0
0
1080
10587
1.12
0.79
4.4
4.0
4.71
4.72
mmol/l
0.13
1004
9978
44
349
1.27
0.78
1.9
2.0
1.06
2.04
ug/l
0.50
37
315
17
115
1.48
0.77
1.2
1.1
—
—
—
0
0
317
2949
1.10
0.76
3.5
2.9
—
—
—
0
0
13
197
0.66
0.75
1.2
1.2
—
—
—
0
0
11
67
1.65
0.75
1.5
1.6
—
—
—
0
0
84
718
1.18
0.74
2.0
2.2
5.77
7.64
ug/l
0.69
70
645
5
24
2.09
0.74
1.0
1.0
—
—
—
0
0
26
193
1.35
0.73
2.3
2.3
133.90
130.76
g/l
0.24
21
148
92
794
1.17
0.73
8.8
8.3
1.32
1.36
mmol/l
0.17
92
776
5
25
2.00
0.72
1.0
1.1
—
—
—
0
0
31
238
1.31
0.71
1.0
1.1
3.92
7.07
u/ml
0.77
14
131
81
694
1.18
0.71
1.1
1.2
—
—
—
0
0
86
741
1.17
0.70
10.4
9.9
—
—
—
0
0
30
230
1.31
0.70
1.0
1.1
0.55
1.87
u/ml
0.94
11
105
13
85
1.53
0.69
1.2
1.1
—
—
—
0
0
5
27
1.85
0.68
1.0
1.0
4.95
7.81
mg/g
—
5
27
32
249
1.29
0.67
1.0
1.1
—
—
—
0
0
73
624
1.18
0.66
2.5
2.7
164.14
154.11
ng/l
0.08
64
558
50
412
1.22
0.66
1.6
2.2
20.22
21.19
s
1.30
45
367
227
2093
1.10
0.66
1.7
1.7
—
—
—
0
0
41
331
1.25
0.65
3.2
3.6
844.88
4206.40
u/ml
0.57
34
286
25
189
1.33
0.64
1.2
1.2
2.07
5.19
u/ml
1.56
15
77
35
278
1.27
0.64
2.5
2.8
—
—
—
0
0
5
29
1.73
0.64
1.2
1.9
11.38
18.02
umol/l
—
5
29
281
2624
1.09
0.63
3.3
3.4
616.39
291.11
mg/l
0.37
174
1741
248
2304
1.09
0.62
3.9
3.2
—
—
—
0
0
732
7093
1.07
0.62
3.8
3.3
—
—
—
0
0
11
71
1.55
0.62
2.5
2.5
42.17
44.82
%
—
6
41
278
2597
1.09
0.62
7.3
6.5
—
—
—
0
0
8
50
1.60
0.61
1.3
1.3
—
—
—
0
0
380
3598
1.08
0.61
3.3
3.3
33.07
31.62
u/l
0.33
366
3424
43
353
1.23
0.60
7.1
6.8
0.98
0.88
%
1.30
38
330
30
236
1.28
0.60
1.6
3.6
31.40
75.60
mg/l
0.90
24
190
30
236
1.28
0.60
1.6
3.6
58.72
31.51
mg/l
0.55
24
190
176
1612
1.11
0.59
2.9
2.9
2.44
2.44
mmol/l
0.47
156
1423
161
1470
1.11
0.58
2.4
2.3
15.12
13.93
umol/l
1.04
155
1369
6
35
1.72
0.57
1.0
1.6
—
—
—
0
0
366
3474
1.07
0.55
3.7
3.5
68.36
84.31
e6/l
0.22
262
2405
23
177
1.30
0.55
1.0
1.1
3.31
5.53
u/ml
—
7
75
243
2271
1.09
0.54
4.0
3.5
1.02
1.02
kg/l
0.74
33
300
6
38
1.58
0.54
1.2
1.3
—
—
—
0
0
11
74
1.49
0.53
1.1
1.1
3.18
6.04
iu/ml
—
5
19
6
39
1.54
0.53
1.0
1.6
—
—
—
0
0
109
982
1.12
0.51
2.7
2.5
35.52
87.14
u/l
0.54
90
841
489
4700
1.06
0.51
10.1
8.8
0.00
0.00
e9/l
0.20
406
3882
52
445
1.18
0.50
3.9
3.1
—
—
—
0
0
10
67
1.50
0.49
1.4
1.2
—
—
—
0
0
90
806
1.13
0.48
3.7
3.7
2.04
1.91
mmol/l
0.18
78
670
39
327
1.20
0.47
1.1
1.2
—
—
—
0
0
21
164
1.29
0.46
2.4
2.3
—
—
—
0
0
21
164
1.29
0.46
1.4
1.2
16.28
27.31
u/l
0.72
21
142
157
1452
1.09
0.46
1.7
1.7
—
—
—
0
0
7
49
1.43
0.46
1.0
1.1
—
—
—
0
0
30
246
1.22
0.45
1.4
1.5
—
—
—
0
0
18
138
1.31
0.45
2.1
3.2
—
—
—
0
0
7
51
1.37
0.44
1.0
1.0
—
—
—
0
0
134
1234
1.10
0.44
1.6
1.4
—
—
—
0
0
39
331
1.18
0.43
1.6
1.3
—
—
—
0
0
5
31
1.62
0.43
1.0
1.2
—
—
—
0
0
49
425
1.16
0.42
1.6
1.4
8.30
8.68
u/l
0.09
41
353
8
57
1.41
0.42
1.8
1.4
21.66
30.09
umol/l
—
8
52
8
58
1.38
0.41
4.6
7.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.4
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
1.90
—
0
16
8
59
1.36
0.41
1.0
1.1
776.86
222.97
iu/ml
—
8
59
23
186
1.24
0.40
2.4
2.4
17.09
16.27
%
0.38
16
96
0
18
0.00
0.40
0.0
1.3
—
23.51
—
0
13
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
42
362
1.17
0.40
1.0
1.1
0.64
4.98
u/ml
—
5
50
27
223
1.22
0.40
4.6
4.1
—
—
—
0
0
28
233
1.21
0.38
1.0
1.1
4.02
2.29
u/ml
0.29
12
124
129
1195
1.09
0.38
3.0
2.7
5.78
7.93
umol/l
1.21
110
1038
9
66
1.37
0.38
1.2
1.2
5.69
6.52
mmol/l
—
9
60
5
36
1.39
0.38
1.6
1.1
—
—
—
0
0
14
107
1.31
0.37
1.0
1.3
—
—
—
0
0
98
900
1.10
0.36
4.6
3.5
—
—
—
0
0
5
79
0.63
0.35
1.8
1.2
—
—
—
0
0
5
80
0.62
0.35
1.6
1.4
89.20
76.06
umol/l
—
5
80
24
199
1.21
0.35
1.0
1.1
2.12
3.18
u/ml
—
10
102
6
43
1.40
0.35
3.7
2.7
—
—
—
0
0
27
319
0.84
0.34
6.9
8.9
—
—
—
0
0
81
885
0.91
0.33
1.4
1.4
—
—
—
0
0
6
46
1.31
0.33
1.0
2.4
15.13
202.15
ug/l
—
6
38
11
83
1.33
0.32
1.1
1.4
—
—
—
0
0
7
98
0.71
0.31
2.3
2.2
—
—
—
0
0
12
153
0.78
0.30
2.5
2.5
—
—
—
0
0
22
184
1.20
0.30
1.1
1.1
9.33
55.64
iu/ml
—
9
48
7
54
1.30
0.30
1.7
1.6
1.84
5.66
nmol/l
—
7
47
138
1298
1.07
0.30
1.7
1.7
—
—
—
0
0
13
102
1.28
0.30
1.8
2.2
—
—
—
0
0
82
757
1.09
0.29
1.4
1.3
151.57
233.51
u/ml
0.94
76
706
14
112
1.25
0.28
2.7
2.9
—
—
—
0
0
184
1755
1.06
0.27
2.9
2.7
0.68
0.72
ug/l
0.40
109
1039
22
187
1.18
0.26
3.4
2.7
—
—
—
0
0
10
77
1.30
0.26
1.0
1.1
—
—
—
0
0
10
77
1.30
0.26
1.0
1.0
—
—
—
0
0
34
301
1.13
0.25
5.8
2.7
—
—
—
0
0
32
283
1.13
0.24
1.3
2.0
9.73
10.23
g/l
0.27
27
260
21
244
0.86
0.24
1.2
1.2
—
—
—
0
0
252
2432
1.04
0.24
2.2
2.1
2.84
2.85
mg/l
0.04
216
2094
33
293
1.13
0.24
1.8
1.9
4.99
4.85
iu/l
0.02
11
102
67
620
1.09
0.23
2.8
2.4
—
—
—
0
0
23
199
1.16
0.23
1.1
1.1
—
—
—
0
0
5
39
1.28
0.23
1.6
2.6
—
32.69
—
0
8
315
3241
0.96
0.22
1.6
1.5
—
—
—
0
0
50
458
1.10
0.22
1.3
1.3
241.49
220.72
miu/ml
0.13
25
224
41
451
0.91
0.22
1.5
1.7
—
—
—
0
0
5
42
1.19
0.21
2.2
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
4.9
—
—
—
0
0
12
145
0.83
0.21
1.2
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
21
183
1.15
0.20
1.3
1.2
—
—
—
0
0
52
560
0.93
0.19
1.1
1.1
—
—
—
0
0
43
397
1.09
0.17
2.5
3.4
25.34
25.13
mmol/l
0.18
43
385
18
157
1.15
0.17
1.1
1.1
—
—
—
0
0
268
2750
0.97
0.17
1.6
1.7
1.36
1.42
mmol/l
0.61
235
2356
19
167
1.14
0.17
1.4
1.2
—
—
—
0
0
12
101
1.19
0.16
1.7
2.4
—
—
—
0
0
8
72
1.11
0.16
1.9
1.1
—
—
—
0
0
13
151
0.86
0.15
1.5
1.4
7.09
7.25
mmol/l
0.07
13
132
423
4304
0.97
0.15
2.6
2.5
—
—
—
0
0
24
216
1.11
0.15
3.1
3.8
57.04
55.87
%
0.17
24
216
12
102
1.18
0.15
2.0
2.2
32.58
32.83
pg
0.05
12
102
9
82
1.10
0.15
1.0
1.1
—
—
—
0
0
9
82
1.10
0.15
1.6
1.6
—
—
—
0
0
24
217
1.11
0.14
1.7
1.5
0.26
0.36
nmol/l
0.74
18
182
13
112
1.16
0.14
1.1
1.4
—
—
—
0
0
25
228
1.10
0.13
1.4
1.5
106.57
100.59
u/ml
—
7
47
23
209
1.10
0.13
2.9
3.4
3.99
4.11
e9/l
0.13
23
209
27
248
1.09
0.12
1.6
1.6
—
—
—
0
0
27
248
1.09
0.12
2.3
2.2
—
—
—
0
0
69
722
0.95
0.12
1.5
1.7
—
—
—
0
0
36
338
1.07
0.11
6.6
4.7
—
—
—
0
0
952
9570
0.98
0.10
16.3
14.5
14.83
14.52
%
0.84
938
9399
10
87
1.15
0.09
1.2
1.1
—
—
—
0
0
5
48
1.04
0.09
4.8
3.3
—
—
—
0
0
6
54
1.11
0.09
2.0
1.4
216.17
180.38
mmol/24h
—
6
54
18
165
1.09
0.08
1.1
1.4
—
—
—
0
0
6
56
1.07
0.08
1.2
1.4
—
—
—
0
0
19
175
1.09
0.08
6.2
2.8
—
—
—
0
0
5
65
0.77
0.08
1.0
1.3
27.80
38.12
nmol/l
—
5
53
5
65
0.77
0.08
1.4
3.7
—
—
—
0
0
6
71
0.84
0.07
1.0
1.0
—
4.00
—
0
21
6
74
0.81
0.07
1.2
1.4
1.56
1.54
g/l
—
6
74
17
184
0.92
0.07
1.1
1.4
—
—
—
0
0
8
76
1.05
0.07
1.6
2.1
—
—
—
0
0
149
1462
1.02
0.07
1.5
1.4
—
—
—
0
0
7
85
0.82
0.07
1.0
1.2
—
—
—
0
0
8
95
0.84
0.06
1.0
1.6
9.65
11.94
umol/l
—
8
88
11
100
1.10
0.05
1.3
1.4
82.54
167.44
pmol/l
2.09
11
100
27
258
1.05
0.04
1.4
1.3
185.10
238.84
u/ml
0.81
21
163
19
200
0.95
0.03
1.0
1.0
1.73
2.31
u/ml
—
10
94
31
320
0.97
0.03
6.7
4.1
1.41
1.36
mmol/l
0.14
31
312
22
211
1.04
0.03
1.0
1.1
—
—
—
0
0
20
208
0.96
0.02
2.9
3.4
27.38
26.38
mg/l
—
8
126
23
238
0.97
0.02
1.5
1.4
858.56
880.43
e6/l
0.01
18
191
23
238
0.97
0.02
1.4
1.4
12.75
10.46
e6/l
0.08
16
185
28
273
1.03
0.01
1.3
1.1
—
—
—
0
0
12
124
0.97
0.00
2.1
1.6
—
—
—
0
0
80
804
0.99
0.00
7.7
7.8
8.29
8.75
mmol/l
0.29
75
770
30
302
0.99
0.00
1.2
1.2
—
—
—
0
0
12
119
1.01
0.00
2.5
3.0
0.93
0.90
nmol/l
0.07
12
92
140
1399
1.00
0.00
1.4
1.3
—
—
—
0
0
23
235
0.98
0.00
1.1
1.3
—
—
—
0
0
21
205
1.02
0.00
1.3
1.4
27.14
21.35
u/l
0.23
14
175
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
5.2
—
—
—
0
0
0
5
0.00
0.00
0.0
4.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
7
72
0.97
0.00
2.0
2.2
12.09
11.25
%
—
7
72
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
66
0.91
-0.00
1.7
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
5.3
—
401.86
—
0
7
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
-0.00
2.2
1.2
—
—
—
0
0
10
100
1.00
-0.00
1.1
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
50
1.00
-0.00
1.6
1.4
129.60
153.00
nmol/l
—
5
50
8
79
1.01
-0.00
1.0
1.2
—
—
—
0
0
8
84
0.95
-0.00
1.8
3.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_BONE_LONG_LOWER and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_BONE_LONG_LOWER 1.158 [0.95, 1.41] 0.149
Birth year 0.994 [0.99, 1.0] 0.166

During the follow-up period (1.1.1998 — 31.12.2019), 134 out of 2886 females with CD2_BENIGN_BONE_LONG_LOWER died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_BONE_LONG_LOWER 1.061 [0.88, 1.28] 0.529
Birth year 0.985 [0.98, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 164 out of 3257 males with CD2_BENIGN_BONE_LONG_LOWER died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_BONE_LONG_LOWER.

N-year risk Females Males
1 0.124% 0.179%
5 0.617% 1.067%
10 1.529% 2.808%
15 3.177% 5.416%
20 5.471% 9.13%

Relationships between endpoints

Index endpoint: CD2_BENIGN_BONE_LONG_LOWER – Benign neoplasm: Long bones of lower limb

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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