Other vitreous opacities

H7_VITROPACIT

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H43.3
  • Cause of death: ICD-10 H43.3

2 out of 7 registries used, show all original rules.

1397

4. Check minimum number of events

None

1397

5. Include endpoints

None

1397

6. Filter based on genotype QC (FinnGen only)

1397

Control definitions (FinnGen only)

Control exclude
H7_VITREOUS

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H43
Name in latin
Opacitates corporis vitrei

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 9084 5174 3874
Only index persons 8664 4997 3667
Unadjusted period prevalence (%)
Whole population 0.13 0.15 0.11
Only index persons 0.17 0.18 0.14
Median age at first event (years)
Whole population 62.97 61.94 64.41
Only index persons 62.64 61.65 64.00

-FinnGen-

Key figures

All Female Male
Number of individuals 1397 811 586
Unadjusted period prevalence (%) 0.27 0.28 0.26
Median age at first event (years) 62.49 59.59 66.51

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1273
Matched controls
12728
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H43.3
ICD-10 Finland
Other vitreous opacities
4503599627370496.0
323.0
1272
16
H43.8
ICD-10 Finland
Other disorders of vitreous body
57.6
243.7
287
64
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
16.2
72.7
120
81
H43.1
ICD-10 Finland
Vitreous haemorrhage
154.7
69.7
73
5
Z96.1
ICD-10 Finland
Presence of intraocular lens
3.9
59.0
281
868
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.6
48.2
490
2494
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.6
46.6
236
754
H33.3
ICD-10 Finland
Retinal breaks without detachment
7.9
39.4
93
126
H33.0
ICD-10 Finland
Retinal detachment with retinal break
8.4
38.5
87
110
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.8
37.6
286
1200
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
2.2
37.2
519
2999
H43.2
ICD-10 Finland
Crystalline deposits in vitreous body
190.3
35.9
37
*
H26.4
ICD-10 Finland
After-cataract
3.4
35.9
192
633
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.5
35.1
176
551
CKC12
NOMESCO Finland
Photocoagulation of retina
6.0
34.1
98
175
H53.1
ICD-10 Finland
Subjective visual disturbances
4.2
33.4
133
340
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.4
32.6
169
542
H25.1
ICD-10 Finland
Senile nuclear cataract
2.2
30.8
378
2016
H53.9
ICD-10 Finland
Visual disturbance, unspecified
7.3
29.0
71
102
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.9
25.1
563
3760
WX140
NOMESCO Finland
Parabulbar anesthesy
4.3
25.0
97
241
H04.10
ICD-10 Finland
Dry eye syndrome
2.7
23.6
170
676
H52.1
ICD-10 Finland
Myopia
5.7
22.4
65
118
H43.9
ICD-10 Finland
Disorder of vitreous body, unspecified
34.4
21.2
27
8
AA1AD
NOMESCO Finland
CT of head and brain
1.8
16.6
316
1931
CKD40
NOMESCO Finland
Endophotocoagulation of retina
8.1
16.6
37
47
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.9
16.2
106
393
XCK00
NOMESCO Finland
Perimetry
2.8
16.0
109
417
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
3.7
16.0
71
201
F05
ICPC
Visual disturbance other
4.9
15.4
50
105
H25.0
ICD-10 Finland
Senile incipient cataract
2.7
15.0
103
395
R42
ICD-10 Finland
Dizziness and giddiness
1.8
14.7
283
1725
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
14.6
433
3011
A02BC02
ATC
pantoprazole; systemic
1.6
14.6
804
6566
F04
ICPC
Visual floaters/spots
17.2
14.3
22
13
XCK10
NOMESCO Finland
Photography of fundus of eye
2.3
14.1
143
676
R51.80
ICD-10 Finland
Headache
2.1
14.0
175
908
S01BC05
ATC
ketorolac; ophthalmic
3.3
13.8
71
226
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
3.7
13.6
60
169
SAA01
NOMESCO Finland
Simple examination of mouth
1.6
13.1
809
6698
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.6
12.9
607
4705
H20.1
ICD-10 Finland
Chronic iridocyclitis
9.1
12.8
26
29
R07.4
ICD-10 Finland
Chest pain, unspecified
1.7
12.7
339
2272
M54.5
ICD-10 Finland
Low back pain
1.6
12.5
383
2661
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
2.8
12.5
82
309
CKC10
NOMESCO Finland
Local photocoagulation of retina
5.6
12.3
35
64
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
12.3
362
2491
H25.8
ICD-10 Finland
Other senile cataract
2.1
12.2
152
786
N03AX12
ATC
gabapentin; oral
1.9
11.8
192
1101
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
5.6
11.7
33
60
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.4
11.5
101
445
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
5.7
11.5
32
57
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
3.2
11.5
60
195
H26.2
ICD-10 Finland
Complicated cataract
6.5
11.1
28
44
SAA03
NOMESCO Finland
Extended examination of mouth
1.5
11.1
429
3146
UJF32
NOMESCO Finland
Coloscopy
1.6
10.9
328
2259
R20.2
ICD-10 Finland
Paraesthesia of skin
2.5
10.9
86
361
J02AC01
ATC
fluconazole; systemic
1.5
10.4
460
3465
SPAT1263
SPAT
Sampling
1.5
10.3
512
3953
S01FA04
ATC
cyclopentolate; ophthalmic
6.7
10.2
25
38
SPAT1301
SPAT
No procedures
1.5
10.2
387
2809
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
2.7
10.0
68
262
L03
ICPC
Low back symptom/complaint
1.6
10.0
289
1960
WX100
NOMESCO Finland
Conjunctival surface anesthesia
1.9
10.0
145
797
G44.2
ICD-10 Finland
Tension-type headache
1.9
9.8
155
876
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
4.9
9.8
31
65
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.1
9.7
109
540
A02BC03
ATC
lansoprazole; oral
1.6
9.7
345
2458
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.6
9.7
72
291
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
9.7
470
3597
M79.6
ICD-10 Finland
Pain in limb
1.5
9.5
411
3065
J01CA04
ATC
amoxicillin; systemic
1.5
9.3
951
8435
A02BC01
ATC
omeprazole; systemic
1.5
9.2
324
2304
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.4
9.1
621
5068
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
4.2
9.1
33
80
A98
ICPC
Health maint/preventive medicine
1.9
9.1
1184
11131
H43
ICD-10 Finland
Disorders of vitreous body
15.7
9.0
14
9
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.8
9.0
148
846
A06AC01
ATC
ispaghula (psylla seeds); oral
1.6
9.0
292
2034
M03BX02
ATC
tizanidine; oral
1.4
8.9
697
5827
ZXA00
NOMESCO Finland
Right side
1.5
8.9
331
2381
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.7
8.9
195
1225
F29
ICPC
Eye symptom/complaint other
2.1
8.9
101
506
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.4
8.9
618
5057
SPAT1097
SPAT
Recording of ECG
1.7
8.8
194
1218
H35.4
ICD-10 Finland
Peripheral retinal degeneration
7.2
8.7
20
28
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.5
8.6
316
2261
S01ED01
ATC
timolol; ophthalmic
2.8
8.6
52
188
H53.8
ICD-10 Finland
Other visual disturbances
5.8
8.6
23
40
L08
ICPC
Shoulder symptom/complaint
1.6
8.5
223
1467
CKC60
NOMESCO Finland
Local buckling of sclera using implant
10.1
8.5
16
16
J01DB01
ATC
cefalexin; oral
1.5
8.5
971
8701
K02.1
ICD-10 Finland
Caries of dentine
1.4
8.5
611
5012
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
4.9
8.4
26
54
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
4.5
8.4
28
63
N03AX16
ATC
pregabalin; oral
1.5
8.3
274
1915
R02
ICPC
Shortness of breath/dyspnoea
1.8
8.3
149
880
S18
ICPC
Laceration/cut
1.4
8.3
495
3916
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.6
8.2
218
1440
H34.8
ICD-10 Finland
Other retinal vascular occlusions
3.9
8.2
32
84
H53.2
ICD-10 Finland
Diplopia
3.0
8.2
45
154
A02BA02
ATC
ranitidine; systemic
1.6
8.2
242
1643
ZXA10
NOMESCO Finland
Bilateral
1.6
8.1
226
1512
G04CB01
ATC
finasteride; oral (testosterone-5-alpha reductase inhibitors)
1.8
8.1
130
739
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
5.9
8.0
21
36
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
8.0
244
1671
P20
ICPC
Memory disturbance
1.7
7.9
151
909
R03AC02
ATC
salbutamol; inhalant
1.4
7.9
591
4861
SPAT1153
SPAT
Removal of sutures
1.5
7.8
382
2897
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.9
7.8
113
620
SAA02
NOMESCO Finland
Basic examination of mouth
1.4
7.7
701
5951
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.7
7.7
157
964
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.5
7.7
263
1846
A04
ICPC
Weakness/tiredness general
1.7
7.7
150
909
N02AX02
ATC
tramadol; systemic, rectal
1.4
7.6
490
3915
H30.2
ICD-10 Finland
Posterior cyclitis
25.2
7.6
10
*
F13
ICPC
Eye sensation abnormal
3.1
7.6
39
128
N06AX11
ATC
mirtazapine; oral
1.5
7.4
350
2634
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
7.4
494
3963
G47.3
ICD-10 Finland
Sleep apnoea
1.6
7.4
227
1552
S04
ICPC
Lump/swelling localized
1.9
7.4
108
596
H33.5
ICD-10 Finland
Other retinal detachments
7.7
7.4
16
21
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
7.4
419
3266
SPAT1240
SPAT
Therapeutic discussion
1.9
7.4
111
618
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.8
7.4
134
794
I49.4
ICD-10 Finland
Other and unspecified premature depolarization
2.6
7.3
51
201
N02BE01
ATC
paracetamol; systemic, rectal
1.5
7.3
1046
9609
CKD99
NOMESCO Finland
Other intraoclular operations on vitreous body and retina
+∞
7.3
7
*
H36.00
ICD-10 Finland
Diabetic background retinopathy
4.3
7.2
25
59
G04CA01
ATC
alfuzosin; oral
1.7
7.2
135
809
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.4
7.2
522
4248
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.6
7.1
206
1391
SPAT1260
SPAT
Consultation of another employee
1.6
7.0
212
1446
S01BC03
ATC
diclofenac; ophthalmic
3.3
7.0
33
102
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.4
7.0
337
2539
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.8
7.0
110
623
SPAT1312
SPAT
General health counselling
1.4
6.9
357
2727
S01EC01
ATC
acetazolamide; systemic
3.5
6.9
30
87
CA1ME
NOMESCO Finland
Ultrasound oculometry
7.6
6.9
15
20
M25.5
ICD-10 Finland
Pain in joint
1.5
6.9
306
2271
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.8
6.9
116
669
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.5
6.9
231
1614
L12
ICPC
Hand/finger symptom/complaint
1.7
6.9
160
1019
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
1.9
6.8
101
559
Z01.2
ICD-10 Finland
Dental examination
1.4
6.8
438
3479
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.4
6.8
431
3416
M71.0
ICD-10 Finland
Abscess of bursa
9.4
6.8
13
14
CKC30
NOMESCO Finland
Cryopexy of detached retina
9.4
6.8
13
14
Z01.4
ICD-10 Finland
Gynaecological examination (general)(routine)
1.6
6.8
164
1058
SPAT1310
SPAT
Counselling related to known health issue
1.4
6.7
363
2795
D01
ICPC
Abdominal pain/cramps general
1.8
6.7
118
692
N06AA09
ATC
amitriptyline; systemic
1.8
6.7
123
731
H3600, E113
ICD-10 Finland
NA
4.0
6.7
25
64
H02AB06
ATC
prednisolone; systemic
1.4
6.7
540
4454
WX290
NOMESCO Finland
Other blockade of nerve
1.4
6.6
438
3493
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
6.6
504
4115
A02BC05
ATC
esomeprazole; systemic
1.4
6.6
450
3608
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.0
6.6
82
428
J01AA02
ATC
doxycycline; systemic
1.4
6.6
915
8245
G63.2
ICD-10 Finland
Diabetic polyneuropathy
10.1
6.5
12
12
H43.0
ICD-10 Finland
Vitreous prolapse
70.2
6.4
7
*
XJH00
NOMESCO Finland
Transanal ultrasonography
2.0
6.4
78
401
WX142
NOMESCO Finland
Sub-tenon anesthesy
7.4
6.4
14
19
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
7.4
6.4
14
19
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
3.8
6.4
25
67
H57.1
ICD-10 Finland
Ocular pain
2.7
6.4
41
154
R05
ICPC
Cough
1.5
6.4
244
1754
D19
ICPC
Teeth/gum symptom/complaint
1.5
6.4
266
1946
H53.4
ICD-10 Finland
Visual field defects
3.1
6.3
32
105
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.5
6.3
222
1567
H33.2
ICD-10 Finland
Serous retinal detachment
18.1
6.3
9
5
D06
ICPC
Abdominal pain localized other
1.9
6.2
89
488
N01
ICPC
Headache
1.8
6.2
98
554
CKC15
NOMESCO Finland
Panretinal photocoagulation
7.1
6.2
14
20
SDA01
NOMESCO Finland
Simple parodonthologic therapy
1.5
6.2
259
1894
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
7.7
6.1
13
17
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
1.9
6.1
90
500
WX110
NOMESCO Finland
Local anesthesy
1.3
6.1
762
6699
H3603, E103
ICD-10 Finland
NA
8.6
6.1
12
14
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.3
6.0
555
4654

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
535
3689
1.73
20.51
2.7
2.5
54.7
57.1
u/l
0.94
492
3390
755
5938
1.59
15.86
6.7
6.6
1.2
1.2
mmol/l
0.15
630
4975
1059
9049
1.70
15.82
8.2
7.6
76.7
78.9
u/l
0.75
999
8496
699
5410
1.58
15.65
5.8
5.9
1.2
1.2
mmol/l
0.21
626
4875
183
990
1.98
14.97
3.6
3.4
—
—
—
0
0
1013
8613
1.64
14.80
5.0
4.1
13.2
12.9
mm/h
0.22
928
7909
603
4573
1.56
14.33
4.5
3.7
53.8
50.9
ng/l
0.05
427
3276
638
4912
1.55
14.09
10.5
9.6
1.2
1.3
inr
1.73
182
1416
958
8094
1.58
13.79
5.4
4.4
—
—
—
0
0
711
5627
1.54
13.72
4.6
3.7
0.0
0.0
estimate
0.00
149
1093
351
2386
1.63
13.05
1.3
1.2
2.4
1.9
u/ml
0.14
106
626
712
5707
1.50
12.48
4.6
3.7
0.0
0.0
estimate
0.06
146
1065
759
6178
1.50
12.25
6.1
6.3
10.6
11.5
umol/l
2.27
713
5866
650
5128
1.50
12.21
5.2
4.8
35.0
35.3
g/l
0.59
592
4768
483
3598
1.52
11.86
2.6
2.1
146.0
242.0
u/l
2.64
443
3371
831
6920
1.50
11.79
4.9
4.8
6.7
6.7
mmol/l
0.02
789
6488
701
5645
1.49
11.73
6.0
5.0
0.0
0.0
estimate
0.00
154
1097
1289
11927
2.04
11.72
20.7
17.2
139.8
139.7
mmol/l
0.92
1255
11594
1291
11955
2.05
11.66
20.8
17.3
4.0
4.0
mmol/l
0.64
1256
11601
334
2313
1.58
11.29
1.8
1.8
1159.2
1193.2
nmol/l
0.29
249
1735
1286
11913
2.00
11.28
18.7
14.2
—
—
—
0
0
912
7801
1.49
10.87
5.8
4.5
155.6
1781.0
e6/l
—
8
120
1180
10688
1.67
10.77
6.8
5.9
40.1
40.0
mmol/mol
0.16
1067
9822
1245
11472
1.78
10.29
18.4
14.8
23.6
24.5
mg/l
0.41
997
9115
697
5701
1.44
10.21
6.1
5.6
0.0
0.0
e9/l
0.46
627
4920
201
1257
1.70
10.12
2.6
2.2
126.4
135.5
ug/g
0.18
161
990
510
3939
1.46
10.09
5.5
5.7
—
—
—
0
0
694
5684
1.44
10.02
6.0
5.6
0.6
0.6
e9/l
0.45
623
4898
707
5832
1.43
9.69
6.3
5.6
2.1
1.9
e9/l
0.32
637
5121
413
3082
1.48
9.65
5.0
4.0
0.0
0.0
estimate
1.08
145
1065
711
5890
1.42
9.41
6.2
5.8
0.2
0.2
e9/l
0.06
637
5161
1002
8838
1.47
9.40
4.6
4.0
15.1
14.9
pmol/l
1.64
908
7973
145
847
1.79
9.26
1.3
1.2
—
—
—
0
0
1338
12692
2.28
9.19
26.6
21.8
6.7
6.7
e9/l
0.01
1300
12309
1337
12685
2.26
9.07
26.6
21.8
244.8
249.2
e9/l
1.81
1307
12346
1337
12688
2.25
9.01
26.5
21.7
91.2
91.3
fl
0.16
1315
12482
1337
12690
2.25
8.97
26.5
21.7
30.3
30.4
pg
0.10
1315
12482
1337
12691
2.25
8.95
26.6
21.8
4.4
4.4
e12/l
1.14
1301
12309
1159
10570
1.57
8.94
5.5
4.8
1.9
2.1
mu/l
0.71
1054
9575
1337
12694
2.24
8.90
26.7
21.9
133.5
134.1
g/l
0.84
1315
12482
785
6685
1.40
8.49
8.5
8.9
4.2
4.1
e9/l
0.64
717
5854
472
3697
1.42
8.28
3.4
3.2
—
—
—
0
0
448
3513
1.41
7.69
4.4
3.9
7.4
7.4
ph
0.40
92
693
347
2603
1.44
7.62
4.8
3.7
—
—
—
0
0
595
4909
1.37
7.44
3.1
2.8
118.6
132.8
ug/l
1.09
537
4482
129
780
1.72
7.31
2.5
2.9
3.8
4.1
e9/l
0.99
90
593
1291
12213
1.75
7.19
12.4
10.6
25.0
25.4
u/l
0.40
1239
11753
662
5580
1.35
7.11
4.5
4.1
—
—
—
0
0
330
2502
1.42
6.73
5.3
4.0
1.0
1.0
kg/l
0.08
34
378
642
5419
1.34
6.69
6.3
5.7
57.5
57.5
%
0.01
604
5060
1234
11577
1.56
6.68
5.7
5.0
2.7
2.7
mmol/l
1.19
1129
10555
1213
11344
1.53
6.59
5.1
4.5
4.6
4.6
mmol/l
0.56
1113
10412
447
3578
1.37
6.57
3.2
3.0
1524.2
1346.1
ng/l
0.38
374
3061
591
4944
1.34
6.48
2.2
2.0
100.8
94.2
pmol/l
2.17
311
2557
388
3042
1.38
6.47
2.3
2.2
3.0
3.0
mg/l
0.08
327
2576
618
5205
1.34
6.46
6.3
5.8
0.7
0.7
%
0.20
582
4851
634
5360
1.33
6.46
6.3
5.8
2.8
2.8
%
0.04
597
4980
636
5381
1.33
6.44
6.5
6.1
8.8
8.7
%
0.32
601
5023
416
3301
1.37
6.43
4.2
4.3
—
—
—
0
0
648
5506
1.33
6.34
6.5
5.9
27.6
27.5
%
0.07
611
5119
338
2598
1.40
6.33
1.7
1.7
445.3
26483378.6
pmol/l
2.12
281
2141
69
360
1.96
6.30
5.8
7.8
1.3
1.3
mmol/l
0.04
64
315
1203
11263
1.49
6.16
5.1
4.5
1.5
1.5
mmol/l
0.74
1097
10262
283
2121
1.42
6.11
1.5
1.4
2.4
2.5
g/l
0.21
176
1257
122
767
1.65
6.00
6.3
7.3
25.4
24.4
mmol/l
2.34
115
717
192
1344
1.50
5.91
1.8
1.7
—
—
—
0
0
1167
10890
1.44
5.81
4.5
4.0
1.3
1.3
mmol/l
0.04
1060
9839
455
3717
1.33
5.68
3.2
3.1
7.0
7.4
mmol/l
1.25
376
3098
127
819
1.61
5.64
4.5
5.1
—
—
—
0
0
363
2872
1.36
5.60
1.6
1.5
20.8
20.9
nmol/l
0.03
311
2423
1196
11230
1.45
5.58
5.4
4.7
5.9
6.0
mmol/l
1.43
1093
10124
435
3540
1.33
5.56
3.6
3.3
951.9
369.9
mg/l
0.93
274
2224
246
1827
1.42
5.55
1.8
2.0
30.0
29.8
s
0.11
230
1771
114
724
1.63
5.40
1.2
1.2
—
—
—
0
0
455
3754
1.31
5.21
4.1
4.0
10.2
9.0
mg/mmol
0.22
279
2322
379
3061
1.33
5.02
3.0
2.7
2711.7
6149.9
umol/l
1.15
329
2633
178
1279
1.45
4.80
1.3
1.3
—
—
—
0
0
163
1152
1.47
4.78
1.8
1.5
—
—
—
0
0
209
1554
1.41
4.66
26.4
24.8
1.5
1.4
inr
0.30
22
209
170
1223
1.44
4.55
4.1
4.2
—
—
—
0
0
226
1710
1.38
4.55
2.3
2.1
—
—
—
0
0
312
2484
1.33
4.51
1.9
1.7
1.4
1.2
mg/l
0.21
245
1914
484
4094
1.28
4.44
3.0
3.5
2.3
2.4
mmol/l
1.11
419
3544
196
1462
1.40
4.29
1.8
1.6
—
—
—
0
0
225
1722
1.37
4.21
2.5
2.4
2.3
2.3
g/l
0.20
207
1593
213
1618
1.37
4.18
2.6
2.5
22.6
22.7
%
0.05
172
1364
283
2247
1.33
4.15
4.4
3.8
162.3
378.6
ng/l
2.17
215
1782
50
277
1.83
3.92
1.2
1.3
211.2
253.2
miu/ml
0.27
16
125
79
499
1.62
3.89
4.8
6.1
1.8
1.6
%
1.37
74
470
546
4749
1.25
3.82
2.2
2.1
—
—
—
0
0
895
8218
1.25
3.79
4.6
3.9
—
—
—
0
0
92
607
1.55
3.78
1.2
1.3
—
—
—
0
0
119
831
1.47
3.74
2.9
2.7
—
—
—
0
0
369
3073
1.27
3.74
3.8
3.4
—
—
—
0
0
238
1874
1.33
3.68
2.5
2.5
12.7
12.9
umol/l
0.13
213
1723
137
991
1.42
3.59
2.8
3.0
66.9
66.3
g/l
0.47
122
901
432
3681
1.25
3.58
5.7
5.2
2.8
2.9
ug/l
0.10
398
3276
77
494
1.59
3.58
3.2
3.9
24.7
25.0
mmol/l
0.34
69
463
119
841
1.45
3.53
2.6
2.8
10.1
10.7
g/l
0.75
107
764
180
1368
1.36
3.52
1.5
1.4
—
—
—
0
0
12
36
3.35
3.48
1.6
1.4
—
—
—
0
0
77
500
1.57
3.41
1.2
1.2
—
—
—
0
0
56
336
1.69
3.39
1.4
1.5
283.7
284.9
ug/g
0.01
30
197
242
1932
1.31
3.38
2.5
3.3
0.8
0.8
mmol/l
1.13
227
1809
138
1012
1.40
3.36
3.5
3.0
163.8
210.7
ng/l
0.77
132
931
144
1065
1.39
3.33
2.4
2.4
4.9
7.2
ug/l
2.21
124
927
64
400
1.63
3.33
1.6
1.6
—
—
—
0
0
47
272
1.75
3.24
3.3
2.1
1147.4
2706.2
u/l
0.65
22
112
26
124
2.12
3.15
1.4
1.6
—
—
—
0
0
26
124
2.12
3.15
1.4
1.6
—
—
—
0
0
26
124
2.12
3.15
1.4
1.6
—
—
—
0
0
26
124
2.12
3.15
1.4
1.6
—
—
—
0
0
122
888
1.41
3.11
4.3
3.9
0.5
0.5
%
0.09
26
220
416
3596
1.22
2.93
4.6
3.9
—
—
—
0
0
150
1142
1.35
2.92
6.2
8.5
121.9
120.7
g/l
0.30
145
1102
162
1249
1.34
2.91
5.9
8.0
96.5
95.5
%
2.09
156
1203
199
1581
1.30
2.89
5.8
5.3
1.0
1.0
mmol/l
0.36
184
1453
57
360
1.61
2.88
11.9
10.5
—
—
—
0
0
84
579
1.48
2.87
2.9
3.6
—
—
—
0
0
95
677
1.43
2.75
2.4
3.3
4.4
4.5
pmol/l
0.36
88
594
113
832
1.39
2.72
1.5
1.4
—
—
—
0
0
27
141
1.93
2.61
3.5
2.7
—
—
—
0
0
98
713
1.40
2.55
2.3
2.2
11.7
12.3
nmol/l
0.24
90
621
175
1391
1.30
2.54
5.8
7.6
5.1
5.1
kpa
0.32
170
1330
175
1391
1.30
2.54
5.8
7.6
12.7
12.1
kpa
0.67
170
1330
39
231
1.71
2.54
1.5
1.2
17.2
9.9
u/l
1.03
32
175
70
478
1.49
2.54
2.8
2.7
—
—
—
0
0
14
56
2.52
2.53
1.0
1.0
—
—
—
0
0
116
871
1.36
2.50
4.8
4.3
0.3
0.5
%
0.16
26
237
174
1388
1.29
2.46
5.8
7.6
1.6
1.2
mmol/l
1.20
147
1071
291
2470
1.23
2.41
4.8
4.5
—
—
—
0
0
122
932
1.34
2.36
4.6
4.1
0.2
0.1
%
0.30
30
277
128
988
1.33
2.31
4.5
4.1
0.8
0.9
%
0.13
32
307
237
1977
1.24
2.31
2.8
2.7
2.6
1.1
e6/l
0.39
160
1151
136
1062
1.31
2.27
3.7
3.5
2.2
1.9
mmol/l
0.26
109
841
20
99
2.04
2.26
1.9
2.1
—
1.7
—
0
5
69
482
1.45
2.26
4.5
4.4
—
—
—
0
0
104
781
1.36
2.26
3.1
3.5
7.4
7.4
ph
0.23
11
98
136
1064
1.31
2.24
3.6
3.5
5.9
5.8
kpa
0.20
131
1030
105
791
1.35
2.24
3.1
3.5
5.1
5.2
kpa
0.16
99
742
85
619
1.40
2.23
7.2
11.2
—
—
—
0
0
91
671
1.38
2.22
2.2
1.7
1.4
1.5
g/l
0.10
77
614
202
1668
1.25
2.16
1.4
1.2
—
—
—
0
0
42
266
1.60
2.16
2.9
3.6
64.4
1447.0
u/ml
0.81
37
246
29
166
1.76
2.16
2.5
2.6
—
—
—
0
0
118
911
1.32
2.14
4.0
3.6
92.9
90.0
ng/l
0.11
93
786
184
1507
1.25
2.12
1.4
1.3
561.8
523.3
titre
0.14
45
315
134
1055
1.30
2.12
2.4
2.1
381.1
372.6
nmol/l
0.17
121
954
17
82
2.09
2.07
1.8
2.4
6.6
6.9
mmol/l
—
7
51
232
1957
1.22
2.04
1.3
1.3
20.5
37.6
iu/ml
3.92
77
613
73
527
1.41
2.03
3.4
2.7
0.6
0.7
%
0.65
73
511
371
3272
1.18
2.02
3.2
3.1
0.2
0.5
e6/l
3.72
309
2501
290
2505
1.20
2.00
2.5
2.6
5.5
5.8
e6/l
0.12
260
2197
556
5073
1.16
1.97
10.6
9.6
0.0
0.0
e9/l
1.35
473
4173
460
4138
1.17
1.96
3.9
3.6
129.2
102.8
e6/l
0.11
353
2978
59
413
1.45
1.95
3.0
3.0
0.2
0.2
g/l
0.08
24
152
28
165
1.71
1.92
1.0
1.1
—
—
—
0
0
154
1252
1.26
1.91
1.6
1.7
—
—
—
0
0
23
128
1.81
1.90
1.2
1.6
—
—
—
0
0
127
1009
1.28
1.89
3.7
3.6
1.2
1.2
mmol/l
0.09
114
871
55
383
1.45
1.88
3.6
3.8
63.8
69.6
mg/l
0.11
49
315
15
72
2.10
1.86
1.2
1.7
—
—
—
0
0
25
144
1.75
1.86
1.1
1.1
—
—
—
0
0
25
144
1.75
1.86
1.1
1.1
—
—
—
0
0
81
606
1.36
1.85
2.7
2.4
—
—
—
0
0
331
2916
1.18
1.82
6.7
6.6
—
—
—
0
0
201
1692
1.22
1.82
2.1
1.8
—
—
—
0
0
97
748
1.32
1.81
2.5
2.5
20.5
22.0
au/ml
—
5
35
36
231
1.57
1.80
1.6
1.3
—
—
—
0
0
6
18
3.34
1.74
1.3
1.7
—
—
—
0
0
34
217
1.58
1.74
2.4
2.8
—
—
—
0
0
7
24
2.93
1.72
1.1
1.2
24.7
26.3
%
—
7
18
19
103
1.86
1.72
1.4
1.3
8.0
7.0
g/l
0.47
12
70
19
103
1.86
1.72
1.4
1.3
2.6
2.7
g/l
0.17
12
69
19
103
1.86
1.72
1.4
1.3
0.4
0.4
g/l
0.09
12
69
13
61
2.14
1.71
3.1
6.6
—
—
—
0
0
11
48
2.30
1.70
4.2
13.3
—
—
—
0
0
0
48
0.00
1.70
0.0
1.8
—
8.7
—
0
40
22
126
1.76
1.68
1.1
1.2
—
—
nmol/l
—
0
0
54
384
1.42
1.68
3.7
3.8
40.4
79.3
mg/l
0.59
48
318
12
55
2.19
1.67
3.9
2.5
757.8
1093.6
u/ml
0.50
12
55
18
97
1.87
1.66
3.2
2.0
4.7
3.8
mg/l
0.26
18
92
99
777
1.30
1.65
4.1
3.0
—
—
—
0
0
7
25
2.81
1.65
1.1
1.1
—
—
—
0
0
7
25
2.81
1.65
1.1
1.1
—
—
—
0
0
7
25
2.81
1.65
1.1
1.1
—
—
—
0
0
50
353
1.43
1.62
1.6
1.3
25.2
30.8
iu/l
0.72
45
293
5
14
3.58
1.61
8.4
14.5
5.5
5.8
mmol/l
—
5
14
104
825
1.28
1.60
1.8
1.6
—
—
—
0
0
23
136
1.70
1.59
1.2
1.4
10377.3
1958.0
e6/l
0.44
17
94
18
99
1.83
1.57
2.1
1.9
1.2
1.1
e9/l
0.23
11
56
354
3170
1.16
1.57
3.2
3.1
—
—
—
0
0
16
85
1.89
1.55
1.1
1.1
—
—
—
0
0
395
3569
1.15
1.54
3.3
3.2
45.1
86.8
e6/l
0.98
329
2781
14
71
1.98
1.54
2.6
2.7
—
—
—
0
0
18
100
1.81
1.53
3.9
2.2
0.2
2.2
u/field
—
5
44
68
512
1.34
1.53
2.0
1.9
1.3
2.1
ug/l
0.44
60
446
20
115
1.75
1.53
1.9
1.5
—
—
—
0
0
244
2128
1.18
1.52
3.5
3.2
0.7
0.8
ug/l
1.29
196
1471
215
1856
1.19
1.51
1.4
1.3
13.2
12.0
u/ml
0.09
86
694
84
654
1.30
1.50
1.3
1.3
148.4
235.3
u/ml
1.06
75
596
5
16
3.13
1.44
1.0
1.1
—
—
—
0
0
48
348
1.39
1.38
1.0
1.1
—
—
—
0
0
67
513
1.32
1.37
2.6
1.9
—
—
—
0
0
137
1147
1.22
1.35
2.1
2.2
0.2
0.2
g/l
0.82
122
1074
329
2967
1.14
1.31
3.7
3.8
88.1
89.2
%
0.34
317
2890
9
43
2.10
1.30
1.0
1.1
—
—
—
0
0
21
129
1.64
1.30
1.9
1.4
0.3
0.3
nmol/l
0.07
15
97
13
69
1.89
1.28
1.1
1.2
—
—
—
0
0
40
285
1.42
1.28
4.0
4.0
—
—
—
0
0
39
278
1.41
1.25
3.3
4.6
2.6
2.7
mmol/l
0.07
26
189
20
123
1.64
1.24
1.6
2.1
—
—
—
0
0
90
729
1.25
1.22
1.6
1.4
—
—
—
0
0
122
1025
1.21
1.18
2.6
2.6
71.7
69.6
e9/l
0.35
105
794
21
133
1.59
1.17
1.1
1.2
—
—
—
0
0
22
141
1.57
1.17
1.1
1.2
—
0.3
nmol/l
—
0
10
5
20
2.51
1.15
1.0
1.1
—
—
—
0
0
23
150
1.54
1.14
1.2
1.3
—
—
—
0
0
7
30
2.34
1.12
1.7
2.0
—
—
—
0
0
8
40
2.01
1.12
1.1
1.1
1480.6
1739.2
miu/ml
—
8
40
153
1320
1.18
1.12
2.3
2.7
9.4
8.4
umol/l
0.17
136
1148
22
143
1.55
1.11
1.1
1.2
0.5
0.7
nmol/l
1.76
22
133
10
51
1.97
1.11
1.0
1.0
—
—
—
0
0
13
73
1.79
1.11
2.0
1.8
10.8
14.1
%
—
6
32
62
487
1.29
1.10
1.1
1.1
—
167.2
titre
—
0
12
20
128
1.57
1.08
2.3
3.9
62.7
53.8
%
0.95
14
90
252
2264
1.14
1.07
3.0
3.1
2.4
2.5
mmol/l
0.28
225
1997
17
105
1.63
1.06
1.5
1.3
—
—
—
0
0
20
129
1.56
1.05
1.5
1.7
—
—
—
0
0
23
154
1.50
1.04
3.2
2.6
—
—
—
0
0
19
123
1.55
1.00
1.2
1.4
11028.6
76145.8
e6/l
—
7
72
5
23
2.18
0.98
1.0
1.1
—
—
—
0
0
58
460
1.27
0.98
3.7
3.6
1.2
1.4
mmol/l
0.90
58
450
21
140
1.51
0.97
1.6
1.2
—
—
—
0
0
0
30
0.00
0.97
0.0
1.4
—
—
—
0
0
14
85
1.65
0.94
1.5
1.3
—
—
—
0
0
19
125
1.53
0.94
4.4
2.4
—
—
—
0
0
7
37
1.90
0.94
1.3
1.3
6.5
3.6
mmol/l
—
7
31
7
37
1.90
0.94
3.9
2.4
—
—
—
0
0
38
286
1.34
0.94
1.7
1.7
14228.5
14802.1
e6/l
0.04
28
214
6
27
2.23
0.93
1.3
1.1
—
—
—
0
0
25
175
1.44
0.93
1.5
1.6
0.6
0.8
g/l
0.49
16
132
122
1052
1.17
0.93
7.6
7.4
9.5
9.9
mmol/l
0.31
110
1004
170
1504
1.15
0.93
5.0
6.9
104.4
104.4
mmol/l
0.01
164
1466
409
3814
1.10
0.91
2.6
2.5
—
—
—
0
0
18
118
1.53
0.91
1.1
1.5
—
—
—
0
0
18
118
1.53
0.91
1.4
1.3
188673.8
48804.0
e6/l
0.34
12
79
16
104
1.54
0.84
1.1
1.2
—
—
—
0
0
16
104
1.54
0.84
3.9
3.3
24.3
39.6
u/ml
0.53
16
104
21
146
1.45
0.82
1.4
1.3
—
—
—
0
0
43
338
1.28
0.81
3.3
4.2
7.4
7.4
ph
0.27
38
273
8
47
1.71
0.80
1.1
1.2
—
0.1
g/l
—
0
5
155
1380
1.14
0.79
2.1
2.6
1.8
1.8
%
0.15
135
1229
52
420
1.25
0.79
1.5
2.0
20.6
21.7
s
1.11
42
371
169
1514
1.13
0.79
1.3
1.3
—
—
—
0
0
18
258
0.69
0.79
2.9
3.6
24.8
26.2
mg/l
—
9
165
15
98
1.54
0.78
1.3
1.1
—
88.8
—
0
5
27
200
1.36
0.76
2.4
3.9
1.0
1.4
%
0.27
21
164
19
132
1.45
0.76
1.1
1.1
1.2
4.9
u/ml
—
7
65
35
271
1.30
0.75
3.2
2.2
—
—
—
0
0
74
625
1.19
0.74
5.0
3.7
—
—
—
0
0
337
3145
1.09
0.74
1.7
1.6
1.4
1.4
mmol/l
0.09
288
2611
7
38
1.85
0.73
1.4
1.6
—
—
—
0
0
259
2389
1.10
0.73
3.1
2.7
549.6
549.9
mosm/kgh2o
0.01
228
2026
15
101
1.49
0.70
1.4
1.4
—
—
—
0
0
7
41
1.71
0.70
1.1
1.4
—
—
—
0
0
5
27
1.85
0.68
9.0
4.4
—
—
—
0
0
20
144
1.39
0.68
3.1
4.8
—
—
—
0
0
332
3111
1.09
0.67
1.4
1.4
—
—
—
0
0
85
736
1.16
0.66
1.2
1.2
138.1
153.3
iu/ml
0.12
28
279
36
286
1.27
0.65
1.3
1.2
—
—
—
0
0
7
44
1.59
0.65
1.1
1.1
409.9
256.9
iu/ml
—
7
44
21
154
1.37
0.65
1.2
1.2
—
—
—
0
0
15
103
1.46
0.65
1.2
1.3
—
—
—
0
0
116
1030
1.14
0.64
4.8
3.8
—
—
—
0
0
19
137
1.39
0.64
1.2
1.2
—
—
—
0
0
312
2922
1.09
0.64
2.6
2.3
—
—
—
0
0
8
129
0.62
0.64
3.3
1.7
—
—
—
0
0
24
181
1.33
0.63
1.5
1.2
—
—
—
0
0
31
243
1.28
0.63
1.2
1.2
—
—
—
0
0
12
176
0.68
0.62
1.3
1.7
—
—
—
0
0
5
30
1.67
0.61
2.0
1.6
—
—
—
0
0
31
244
1.28
0.61
2.0
1.5
0.9
0.8
nmol/l
0.03
24
200
16
113
1.42
0.61
1.3
1.4
—
—
—
0
0
16
113
1.42
0.61
1.7
1.3
—
—
—
0
0
35
281
1.25
0.60
1.3
1.2
2.0
2.3
u/ml
—
7
24
1050
10301
1.08
0.58
18.9
16.0
38.8
39.3
%
0.68
639
7047
8
53
1.51
0.58
5.1
3.0
—
—
—
0
0
39
474
0.82
0.58
1.5
1.7
—
—
—
0
0
8
54
1.48
0.57
1.6
1.2
—
—
—
0
0
44
365
1.21
0.57
2.3
2.6
39.2
37.6
g/l
1.19
35
313
11
73
1.51
0.56
1.0
1.1
243.4
246.5
mg/l
0.04
11
60
202
1869
1.09
0.56
3.0
2.9
2.7
2.6
e6/l
0.09
128
1047
17
124
1.38
0.56
1.2
1.2
—
—
—
0
0
26
204
1.28
0.54
1.8
1.3
—
—
—
0
0
9
61
1.48
0.53
1.0
1.2
—
—
—
0
0
9
63
1.43
0.52
1.4
1.7
—
—
—
0
0
54
628
0.85
0.51
7.5
9.8
24.6
24.4
mmol/l
0.17
54
586
368
3864
0.94
0.51
3.3
2.9
—
—
—
0
0
106
954
1.12
0.51
6.5
8.3
—
—
—
0
0
20
153
1.31
0.50
1.8
1.6
61.5
62.2
%
0.03
13
98
23
290
0.79
0.49
1.2
1.3
—
—
—
0
0
33
271
1.22
0.49
1.4
1.7
—
—
—
0
0
15
110
1.37
0.49
2.4
2.5
—
—
—
0
0
21
163
1.29
0.48
1.1
1.2
1.9
6.4
u/ml
—
7
65
23
181
1.28
0.48
2.4
2.6
—
—
—
0
0
39
329
1.19
0.45
6.1
4.9
—
—
—
0
0
117
1068
1.10
0.45
1.4
1.4
—
—
—
0
0
19
148
1.29
0.43
1.1
1.1
0.8
1.5
u/ml
—
5
59
63
556
1.14
0.43
1.3
1.8
1.5
1.5
g/l
0.16
50
481
8
58
1.38
0.41
5.1
2.8
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
23
187
1.23
0.39
1.7
1.5
—
—
—
0
0
18
142
1.27
0.38
1.4
1.2
—
—
—
0
0
36
308
1.17
0.37
2.8
3.1
1.8
1.6
mg/l
0.37
30
281
959
9438
1.05
0.37
20.4
18.1
13.7
13.8
%
0.54
945
9221
5
37
1.35
0.37
1.2
2.8
—
—
—
0
0
5
37
1.35
0.37
1.0
1.3
—
—
—
0
0
15
116
1.30
0.37
1.1
1.1
0.6
1.2
u/ml
—
5
27
10
72
1.39
0.37
1.1
1.0
—
—
—
0
0
74
817
0.90
0.36
1.3
1.4
—
—
—
0
0
9
71
1.27
0.36
1.4
1.1
—
—
—
0
0
6
42
1.43
0.35
3.8
2.1
18.5
16.8
ug/l
—
6
35
10
73
1.37
0.34
1.6
3.1
—
—
—
0
0
20
163
1.23
0.34
1.0
1.0
—
—
—
0
0
16
127
1.26
0.33
1.1
1.1
0.3
1.7
u/ml
—
5
54
22
182
1.21
0.33
2.0
1.3
121.3
135.5
u/ml
—
8
33
6
86
0.70
0.33
1.3
3.2
11.1
10.7
%
—
6
86
10
74
1.35
0.32
2.7
2.0
455.2
761.6
e6/l
—
5
34
18
146
1.24
0.32
1.3
1.3
—
—
—
0
0
12
92
1.31
0.32
1.3
1.2
10.0
0.7
u/ml
—
7
45
957
9438
1.04
0.31
23.7
19.2
332.1
331.9
g/l
0.28
949
9362
10
131
0.76
0.31
1.0
1.1
—
—
—
0
0
7
100
0.70
0.30
1.1
1.2
—
—
—
0
0
13
102
1.28
0.30
1.1
1.1
—
—
—
0
0
14
172
0.81
0.27
1.3
1.5
—
—
—
0
0
5
72
0.69
0.26
2.6
1.5
—
68.0
—
0
5
5
74
0.67
0.26
1.0
1.1
—
—
—
0
0
38
339
1.12
0.25
1.2
1.2
—
—
—
0
0
25
216
1.16
0.25
1.5
1.6
—
—
—
0
0
14
169
0.83
0.24
1.3
1.4
—
—
—
0
0
81
757
1.07
0.23
6.8
9.0
0.8
0.7
%
2.23
81
750
16
134
1.20
0.23
4.9
6.7
7.5
7.2
mmol/l
0.12
11
113
14
168
0.83
0.22
1.3
1.4
—
—
—
0
0
34
304
1.12
0.22
2.4
2.4
79.1
103.6
ug/min
0.35
20
180
7
91
0.77
0.22
1.0
1.1
—
—
—
0
0
83
779
1.07
0.21
1.2
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.7
—
6.8
—
0
5
0
12
0.00
0.21
0.0
2.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
136
1299
1.05
0.20
3.2
4.2
7.9
24.0
ug/l
1.30
106
1062
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
29
260
1.12
0.19
4.1
3.9
—
—
—
0
0
21
184
1.14
0.19
1.2
1.2
285.5
273.9
u/ml
—
8
97
13
109
1.19
0.18
1.2
1.3
—
32.9
—
0
8
7
59
1.19
0.18
1.1
1.6
6.6
10.1
ug/l
—
7
50
52
557
0.93
0.17
1.7
1.4
—
—
—
0
0
37
402
0.92
0.16
1.1
1.1
—
—
—
0
0
8
68
1.18
0.16
1.5
1.3
—
—
—
0
0
24
215
1.12
0.16
1.3
1.6
—
—
—
0
0
8
69
1.16
0.16
1.6
2.9
1631.3
1855.2
ml
—
8
63
18
158
1.14
0.16
1.8
2.0
89.3
89.9
%
0.19
18
158
21
187
1.12
0.16
1.7
1.4
—
—
—
0
0
22
197
1.12
0.15
1.1
1.3
—
—
—
0
0
109
1048
1.04
0.14
1.7
1.5
—
—
—
0
0
80
764
1.05
0.14
6.5
8.8
1.4
1.4
%
0.36
80
756
12
103
1.17
0.13
1.2
1.0
1.4
1.2
u/ml
—
6
37
14
123
1.14
0.12
1.1
1.3
—
—
—
0
0
11
127
0.87
0.12
1.8
1.8
—
—
—
0
0
31
288
1.08
0.11
1.2
1.2
—
—
—
0
0
22
201
1.10
0.11
2.0
1.3
—
—
—
0
0
10
86
1.16
0.11
1.0
1.2
—
—
—
0
0
5
47
1.06
0.09
1.2
1.6
—
—
—
0
0
29
272
1.07
0.09
1.3
1.9
2.0
5.1
iu/l
—
8
101
6
56
1.07
0.08
1.3
1.9
—
—
—
0
0
6
56
1.07
0.08
1.0
1.2
—
—
—
0
0
5
61
0.82
0.08
2.2
1.4
—
1.5
—
0
10
24
224
1.07
0.08
2.5
3.1
4.1
4.1
e9/l
0.04
24
224
25
234
1.07
0.08
2.7
3.3
56.6
57.5
%
0.10
25
234
6
72
0.83
0.07
1.5
2.8
—
—
—
0
0
105
1074
0.98
0.07
2.3
2.3
113.0
41.6
u/l
0.40
91
920
9
101
0.89
0.06
2.0
1.2
1.9
1.5
nmol/l
—
9
90
78
761
1.03
0.06
7.0
9.0
94.6
93.8
%
1.45
78
754
23
243
0.95
0.05
4.2
3.1
—
—
—
0
0
26
273
0.95
0.05
1.5
1.5
—
—
—
0
0
25
261
0.96
0.04
1.8
1.5
—
—
—
0
0
21
220
0.95
0.03
1.8
1.5
—
—
—
0
0
30
308
0.97
0.02
1.1
1.1
—
—
—
0
0
12
113
1.06
0.02
2.1
1.4
—
—
—
0
0
27
277
0.97
0.01
1.8
1.4
—
—
—
0
0
11
116
0.95
0.00
1.3
1.4
5.3
6.7
mmol/l
0.91
11
108
27
276
0.98
0.00
1.9
1.4
—
—
—
0
0
27
276
0.98
0.00
1.8
1.4
—
—
—
0
0
23
228
1.01
0.00
2.5
2.6
—
—
—
0
0
47
468
1.00
0.00
2.0
3.4
1351.2
8632.1
u/ml
0.65
41
400
25
251
1.00
0.00
2.6
2.6
15.3
16.0
%
0.22
12
128
36
359
1.00
0.00
4.7
3.2
—
—
—
0
0
13
125
1.04
0.00
1.7
3.1
—
—
—
0
0
20
195
1.03
0.00
2.4
1.9
—
—
—
0
0
12
115
1.04
0.00
2.0
2.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
8
83
0.96
0.00
1.3
1.6
1.1
1.0
g/l
—
8
83
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
403.1
—
0
7
5
56
0.89
0.00
16.4
18.5
949.4
1673.0
nmol/l
—
5
56
7
69
1.01
0.00
1.7
1.3
148.8
138.5
nmol/l
—
7
69
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
8
85
0.94
0.00
1.0
1.2
31.0
31.8
mmol/l
—
8
76
0
5
0.00
0.00
0.0
9.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
15.4
—
0
7
0
5
0.00
0.00
0.0
1.0
—
0.1
—
0
5
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
6
65
0.92
0.00
1.2
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
8
79
1.01
0.00
2.1
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H7_VITROPACIT and mortality.

Females

Parameter HR [95% CI] p-value
H7_VITROPACIT 0.973 [0.87, 1.09] 0.646
Birth year 0.995 [0.99, 1.0] 0.253

During the follow-up period (1.1.1998 — 31.12.2019), 644 out of 4409 females with H7_VITROPACIT died.

Males

Parameter HR [95% CI] p-value
H7_VITROPACIT 0.898 [0.79, 1.02] 0.095
Birth year 0.985 [0.98, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 756 out of 3373 males with H7_VITROPACIT died.

Mortality risk

Mortality risk for people of age

years, who have H7_VITROPACIT.

N-year risk Females Males
1 0.087% 0.164%
5 0.541% 1.043%
10 1.374% 2.506%
15 2.673% 4.825%
20 4.5% 8.075%

Relationships between endpoints

Index endpoint: H7_VITROPACIT – Other vitreous opacities

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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