Risteys · H7_VITROPACIT

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H43.3 Cause of death: ICD-10 — H43.3 2 out of 7 registries used, show all original rules.	1397
4. Check minimum number of events None	1397
5. Include endpoints None	1397
6. Filter based on genotype QC (FinnGen only)	1397

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	9084	5174	3874
Only index persons	8664	4997	3667
Unadjusted period prevalence (%)
Whole population	0.13	0.15	0.11
Only index persons	0.17	0.18	0.14
Median age at first event (years)
Whole population	62.97	61.94	64.41
Only index persons	62.64	61.65	64.00

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	1397	811	586
Unadjusted period prevalence (%)	0.27	0.28	0.26
Median age at first event (years)	62.49	59.59	66.51

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
1273: Matched controls
12728

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H43.3

ICD-10 Finland

Other vitreous opacities

4503599627370496.0

323.0

1272

H43.8

ICD-10 Finland

Other disorders of vitreous body

57.6

243.7

287

CKD65

NOMESCO Finland

Pars plana or pars plicata vitrectomy

16.2

72.7

120

H43.1

ICD-10 Finland

Vitreous haemorrhage

154.7

69.7

Z96.1

ICD-10 Finland

Presence of intraocular lens

3.9

59.0

281

868

CJE20

NOMESCO Finland

Phakoemulsification with implantation of artificial lens in posterior chamber

2.6

48.2

490

2494

XCW99

NOMESCO Finland

Other investigative procedure of eye

3.6

46.6

236

754

H33.3

ICD-10 Finland

Retinal breaks without detachment

7.9

39.4

126

H33.0

ICD-10 Finland

Retinal detachment with retinal break

8.4

38.5

110

Z01.0

ICD-10 Finland

Examination of eyes and vision

2.8

37.6

286

1200

S01CA01

ATC

dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)

2.2

37.2

519

2999

H43.2

ICD-10 Finland

Crystalline deposits in vitreous body

190.3

35.9

H26.4

ICD-10 Finland

After-cataract

3.4

35.9

192

633

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

3.5

35.1

176

551

CKC12

NOMESCO Finland

Photocoagulation of retina

6.0

34.1

175

H53.1

ICD-10 Finland

Subjective visual disturbances

4.2

33.4

133

340

CJB10

NOMESCO Finland

Laser discission of secondary cataract

3.4

32.6

169

542

H25.1

ICD-10 Finland

Senile nuclear cataract

2.2

30.8

378

2016

H53.9

ICD-10 Finland

Visual disturbance, unspecified

7.3

29.0

102

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

1.9

25.1

563

3760

WX140

NOMESCO Finland

Parabulbar anesthesy

4.3

25.0

241

H04.10

ICD-10 Finland

Dry eye syndrome

2.7

23.6

170

676

H52.1

ICD-10 Finland

Myopia

5.7

22.4

118

H43.9

ICD-10 Finland

Disorder of vitreous body, unspecified

34.4

21.2

AA1AD

NOMESCO Finland

CT of head and brain

1.8

16.6

316

1931

CKD40

NOMESCO Finland

Endophotocoagulation of retina

8.1

16.6

CK2S4

NOMESCO Finland

Plain photography of ocular fundus

2.9

16.2

106

393

XCK00

NOMESCO Finland

Perimetry

2.8

16.0

109

417

H35.38

ICD-10 Finland

Preretinal fibrosis of the macula

3.7

16.0

201

F05

ICPC

Visual disturbance other

4.9

15.4

105

H25.0

ICD-10 Finland

Senile incipient cataract

2.7

15.0

103

395

R42

ICD-10 Finland

Dizziness and giddiness

1.8

14.7

283

1725

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

1.7

14.6

433

3011

A02BC02

ATC

pantoprazole; systemic

1.6

14.6

804

6566

F04

ICPC

Visual floaters/spots

17.2

14.3

XCK10

NOMESCO Finland

Photography of fundus of eye

2.3

14.1

143

676

R51.80

ICD-10 Finland

Headache

2.1

14.0

175

908

S01BC05

ATC

ketorolac; ophthalmic

3.3

13.8

226

H35.39

ICD-10 Finland

Degeneration of macula and posterior pole

3.7

13.6

169

SAA01

NOMESCO Finland

Simple examination of mouth

1.6

13.1

809

6698

SFA10

NOMESCO Finland

Fillning on one surface of tooth

1.6

12.9

607

4705

H20.1

ICD-10 Finland

Chronic iridocyclitis

9.1

12.8

R07.4

ICD-10 Finland

Chest pain, unspecified

1.7

12.7

339

2272

M54.5

ICD-10 Finland

Low back pain

1.6

12.5

383

2661

H35.30

ICD-10 Finland

Kuhnt-Junius degeneration

2.8

12.5

309

CKC10

NOMESCO Finland

Local photocoagulation of retina

5.6

12.3

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

1.6

12.3

362

2491

H25.8

ICD-10 Finland

Other senile cataract

2.1

12.2

152

786

N03AX12

ATC

gabapentin; oral

1.9

11.8

192

1101

CKD10

NOMESCO Finland

Insufflation of vitreous cavity

5.6

11.7

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

2.4

11.5

101

445

CKD91

NOMESCO Finland

Extended vitrectomy through pars plana

5.7

11.5

H20.0

ICD-10 Finland

Acute and subacute iridocyclitis

3.2

11.5

195

H26.2

ICD-10 Finland

Complicated cataract

6.5

11.1

SAA03

NOMESCO Finland

Extended examination of mouth

1.5

11.1

429

3146

UJF32

NOMESCO Finland

Coloscopy

1.6

10.9

328

2259

R20.2

ICD-10 Finland

Paraesthesia of skin

2.5

10.9

361

J02AC01

ATC

fluconazole; systemic

1.5

10.4

460

3465

SPAT1263

SPAT

Sampling

1.5

10.3

512

3953

S01FA04

ATC

cyclopentolate; ophthalmic

6.7

10.2

SPAT1301

SPAT

No procedures

1.5

10.2

387

2809

CKD05

NOMESCO Finland

Puncture of vitreous body with injection of medication

2.7

10.0

262

L03

ICPC

Low back symptom/complaint

1.6

10.0

289

1960

WX100

NOMESCO Finland

Conjunctival surface anesthesia

1.9

10.0

145

797

G44.2

ICD-10 Finland

Tension-type headache

1.9

9.8

155

876

CKD94

NOMESCO Finland

Combined vitrectomy and procedure on lens through pars plana

4.9

9.8

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

2.1

9.7

109

540

A02BC03

ATC

lansoprazole; oral

1.6

9.7

345

2458

G43.1

ICD-10 Finland

Migraine with aura [classical migraine]

2.6

9.7

291

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

1.5

9.7

470

3597

M79.6

ICD-10 Finland

Pain in limb

1.5

9.5

411

3065

J01CA04

ATC

amoxicillin; systemic

1.5

9.3

951

8435

A02BC01

ATC

omeprazole; systemic

1.5

9.2

324

2304

SFA20

NOMESCO Finland

Filling on two surfaces of tooth

1.4

9.1

621

5068

CS5Z4

NOMESCO Finland

Specialised imaging for glaucoma

4.2

9.1

A98

ICPC

Health maint/preventive medicine

1.9

9.1

1184

11131

H43

ICD-10 Finland

Disorders of vitreous body

15.7

9.0

Z03.89

ICD-10 Finland

Observation for other suspected diseases and conditions

1.8

9.0

148

846

A06AC01

ATC

ispaghula (psylla seeds); oral

1.6

9.0

292

2034

M03BX02

ATC

tizanidine; oral

1.4

8.9

697

5827

ZXA00

NOMESCO Finland

Right side

1.5

8.9

331

2381

R10.1

ICD-10 Finland

Pain localized to upper abdomen

1.7

8.9

195

1225

F29

ICPC

Eye symptom/complaint other

2.1

8.9

101

506

EB1AA

NOMESCO Finland

Tooth X-ray examination

1.4

8.9

618

5057

SPAT1097

SPAT

Recording of ECG

1.7

8.8

194

1218

H35.4

ICD-10 Finland

Peripheral retinal degeneration

7.2

8.7

WZB00

NOMESCO Finland

Telephone receipt or other advice

1.5

8.6

316

2261

S01ED01

ATC

timolol; ophthalmic

2.8

8.6

188

H53.8

ICD-10 Finland

Other visual disturbances

5.8

8.6

L08

ICPC

Shoulder symptom/complaint

1.6

8.5

223

1467

CKC60

NOMESCO Finland

Local buckling of sclera using implant

10.1

8.5

J01DB01

ATC

cefalexin; oral

1.5

8.5

971

8701

K02.1

ICD-10 Finland

Caries of dentine

1.4

8.5

611

5012

CKD92

NOMESCO Finland

Combined vitrectomy and retinal procedure

4.9

8.4

CKD70

NOMESCO Finland

Excision of preretinal or epiretinal membrane

4.5

8.4

N03AX16

ATC

pregabalin; oral

1.5

8.3

274

1915

R02

ICPC

Shortness of breath/dyspnoea

1.8

8.3

149

880

S18

ICPC

Laceration/cut

1.4

8.3

495

3916

K57.3

ICD-10 Finland

Diverticular disease of large intestine without perforation or abscess

1.6

8.2

218

1440

H34.8

ICD-10 Finland

Other retinal vascular occlusions

3.9

8.2

H53.2

ICD-10 Finland

Diplopia

3.0

8.2

154

A02BA02

ATC

ranitidine; systemic

1.6

8.2

242

1643

ZXA10

NOMESCO Finland

Bilateral

1.6

8.1

226

1512

G04CB01

ATC

finasteride; oral (testosterone-5-alpha reductase inhibitors)

1.8

8.1

130

739

H40.5

ICD-10 Finland

Glaucoma secondary to other eye disorders

5.9

8.0

Z01.8

ICD-10 Finland

Other specified special examinations

1.6

8.0

244

1671

P20

ICPC

Memory disturbance

1.7

7.9

151

909

R03AC02

ATC

salbutamol; inhalant

1.4

7.9

591

4861

SPAT1153

SPAT

Removal of sutures

1.5

7.8

382

2897

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

1.9

7.8

113

620

SAA02

NOMESCO Finland

Basic examination of mouth

1.4

7.7

701

5951

M51.1

ICD-10 Finland

Lumbar and other intervertebral disc disorders with radiculopathy

1.7

7.7

157

964

M75.1

ICD-10 Finland

Rotator cuff syndrome

1.5

7.7

263

1846

A04

ICPC

Weakness/tiredness general

1.7

7.7

150

909

N02AX02

ATC

tramadol; systemic, rectal

1.4

7.6

490

3915

H30.2

ICD-10 Finland

Posterior cyclitis

25.2

7.6

F13

ICPC

Eye sensation abnormal

3.1

7.6

128

N06AX11

ATC

mirtazapine; oral

1.5

7.4

350

2634

SPAT1256

SPAT

Intramuscular and subcutaneous injection

1.4

7.4

494

3963

G47.3

ICD-10 Finland

Sleep apnoea

1.6

7.4

227

1552

S04

ICPC

Lump/swelling localized

1.9

7.4

108

596

H33.5

ICD-10 Finland

Other retinal detachments

7.7

7.4

J06.9

ICD-10 Finland

Acute upper respiratory infection, unspecified

1.4

7.4

419

3266

SPAT1240

SPAT

Therapeutic discussion

1.9

7.4

111

618

Z04.8

ICD-10 Finland

Examination and observation for other specified reasons

1.8

7.4

134

794

I49.4

ICD-10 Finland

Other and unspecified premature depolarization

2.6

7.3

201

N02BE01

ATC

paracetamol; systemic, rectal

1.5

7.3

1046

9609

CKD99

NOMESCO Finland

Other intraoclular operations on vitreous body and retina

+∞

7.3

H36.00

ICD-10 Finland

Diabetic background retinopathy

4.3

7.2

G04CA01

ATC

alfuzosin; oral

1.7

7.2

135

809

WYA05

NOMESCO Finland

Emergency visit or other similar visit involving procedures

1.4

7.2

522

4248

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

1.6

7.1

206

1391

SPAT1260

SPAT

Consultation of another employee

1.6

7.0

212

1446

S01BC03

ATC

diclofenac; ophthalmic

3.3

7.0

102

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

1.4

7.0

337

2539

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

1.8

7.0

110

623

SPAT1312

SPAT

General health counselling

1.4

6.9

357

2727

S01EC01

ATC

acetazolamide; systemic

3.5

6.9

CA1ME

NOMESCO Finland

Ultrasound oculometry

7.6

6.9

M25.5

ICD-10 Finland

Pain in joint

1.5

6.9

306

2271

K21.9

ICD-10 Finland

Gastro-oesophageal reflux disease without oesophagitis

1.8

6.9

116

669

R10.3

ICD-10 Finland

Pain localized to other parts of lower abdomen

1.5

6.9

231

1614

L12

ICPC

Hand/finger symptom/complaint

1.7

6.9

160

1019

Z01.5

ICD-10 Finland

Diagnostic skin and sensitization tests

1.9

6.8

101

559

Z01.2

ICD-10 Finland

Dental examination

1.4

6.8

438

3479

SFA30

NOMESCO Finland

Filling on tree or more surfaces of tooth

1.4

6.8

431

3416

CKC30

NOMESCO Finland

Cryopexy of detached retina

9.4

6.8

M71.0

ICD-10 Finland

Abscess of bursa

9.4

6.8

Z01.4

ICD-10 Finland

Gynaecological examination (general)(routine)

1.6

6.8

164

1058

SPAT1310

SPAT

Counselling related to known health issue

1.4

6.7

363

2795

D01

ICPC

Abdominal pain/cramps general

1.8

6.7

118

692

N06AA09

ATC

amitriptyline; systemic

1.8

6.7

123

731

H3600, E113

ICD-10 Finland

4.0

6.7

H02AB06

ATC

prednisolone; systemic

1.4

6.7

540

4454

WX290

NOMESCO Finland

Other blockade of nerve

1.4

6.6

438

3493

GD1AA

NOMESCO Finland

Thorax X-ray examination

1.4

6.6

504

4115

A02BC05

ATC

esomeprazole; systemic

1.4

6.6

450

3608

A10AB05

ATC

insulin aspart; parenteral (insulins and analog. for injection, fast-acting)

2.0

6.6

428

J01AA02

ATC

doxycycline; systemic

1.4

6.6

915

8245

G63.2

ICD-10 Finland

Diabetic polyneuropathy

10.1

6.5

H43.0

ICD-10 Finland

Vitreous prolapse

70.2

6.4

XJH00

NOMESCO Finland

Transanal ultrasonography

2.0

6.4

401

WX142

NOMESCO Finland

Sub-tenon anesthesy

7.4

6.4

E10.2

ICD-10 Finland

Type 1 diabetes mellitus, With renal complications

7.4

6.4

E10.7

ICD-10 Finland

Type 1 diabetes mellitus, With multiple complications

3.8

6.4

H57.1

ICD-10 Finland

Ocular pain

2.7

6.4

154

R05

ICPC

Cough

1.5

6.4

244

1754

D19

ICPC

Teeth/gum symptom/complaint

1.5

6.4

266

1946

H53.4

ICD-10 Finland

Visual field defects

3.1

6.3

105

SPAT1033

SPAT

Irrigation or wax removal of outer auditory canal

1.5

6.3

222

1567

H33.2

ICD-10 Finland

Serous retinal detachment

18.1

6.3

D06

ICPC

Abdominal pain localized other

1.9

6.2

488

N01

ICPC

Headache

1.8

6.2

554

CKC15

NOMESCO Finland

Panretinal photocoagulation

7.1

6.2

SDA01

NOMESCO Finland

Simple parodonthologic therapy

1.5

6.2

259

1894

N08.39*E10.2

ICD-10 Finland

Insulin-dependent diabetes mellitus - Diabetic nephropathy

7.7

6.1

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

1.9

6.1

500

WX110

NOMESCO Finland

Local anesthesy

1.3

6.1

762

6699

H3603, E103

ICD-10 Finland

8.6

6.1

J01CR02

ATC

amoxicillin and beta-lactamase inhibitor; systemic

1.3

6.0

555

4654

Mortality – FinRegistry

↥

Association

Association between endpoint H7_VITROPACIT and mortality.

Females

Parameter	HR [95% CI]	p-value
H7_VITROPACIT	0.973 [0.87, 1.09]	0.646
Birth year	0.995 [0.99, 1.0]	0.253

During the follow-up period (1.1.1998 — 31.12.2019), 644 out of 4409 females with H7_VITROPACIT died.

Males

Parameter	HR [95% CI]	p-value
H7_VITROPACIT	0.898 [0.79, 1.02]	0.095
Birth year	0.985 [0.98, 0.99]	0.003

During the follow-up period (1.1.1998 — 31.12.2019), 756 out of 3373 males with H7_VITROPACIT died.

Mortality risk

Mortality risk for people of age

years, who have H7_VITROPACIT.

N-year risk	Females	Males
1	0.087%	0.164%
5	0.541%	1.043%
10	1.374%	2.506%
15	2.673%	4.825%
20	4.5%	8.075%

Relationships between endpoints

↥

Index endpoint: H7_VITROPACIT – Other vitreous opacities

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	H7_VITROPACIT
CONTROL_EXCLUDE	H7_VITREOUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H433
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H433
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Other vitreous opacities

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints