No definition available.
Gestational [pregnancy-induced] oedema and proteinuria without hypertension
EFO MESH Endpoint Browser PheWeb
O15_GESTAT_OEDEM_PREINUR
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly females |
293373 |
2. Check conditionsNone |
293373 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3609 |
4. Check minimum number of eventsNone |
3609 |
5. Include endpointsNone |
3609 |
6. Filter based on genotype QC (FinnGen only) |
3609 |
Control definitions (FinnGen only)
- Control exclude
- O15_OEDEM_PROTUR_HYPERT
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF5
- Parent code in ICD-10
- O10-O16
- Name in latin
- Oedema et proteinuria gravidarum sine hypertensione
Similar endpoints
↥List of similar endpoints to
Gestational [pregnancy-induced] oedema and proteinuria without hypertension
based on the number of shared cases.
Similar with more cases:
- Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
- Pregnancy, childbirth and the puerperium
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 26938 | 26938 | - |
| Only index persons | 25995 | 25995 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.77 | 0.77 | - |
| Only index persons | 0.96 | 0.96 | - |
| Median age at first event (years) | |||
| Whole population | - | 27.57 | - |
| Only index persons | - | 27.52 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3609 | 3609 | - |
| Unadjusted period prevalence (%) | 1.23 | 1.23 | - |
| Median age at first event (years) | 27.66 | 27.66 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 3285
- Matched controls
- 32850
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
63700
ICD-8 Finland
Pre-eclampsia, eclampsia and toxaemia, unspecified, Albuminuria (proteinuria)
+∞
323.0
840
*
63702
ICD-8 Finland
Pre-eclampsia, eclampsia and toxaemia, unspecified, Oedema
+∞
323.0
852
*
O12.0
ICD-10 Finland
Gestational oedema
1479.0
323.0
502
*
O13
ICD-10 Finland
Gestational [pregnancy-induced] hypertension
1464.5
323.0
388
*
O12.1
ICD-10 Finland
Gestational proteinuria
8748.3
323.0
704
*
6462A
ICD-9 Finland
Other complications of pregnancy, not elsewhere classified, Unspecified renal disease in pregnancy, without mention of hypertension
+∞
246.0
233
*
O14.0
ICD-10 Finland
Mild to moderate pre-eclampsia
+∞
224.6
213
*
63701
ICD-8 Finland
Pre-eclampsia, eclampsia and toxaemia, unspecified, Hypertonia
+∞
171.4
163
*
6461A
ICD-9 Finland
Other complications of pregnancy, not elsewhere classified, Oedema or excessive weight gain in pregnancy, without mention of hypertension
+∞
149.1
142
*
O14.9
ICD-10 Finland
Pre-eclampsia, unspecified
481.2
140.4
139
*
O12.2
ICD-10 Finland
Gestational oedema with proteinuria
+∞
137.5
131
*
63703
ICD-8 Finland
Pre-eclampsia, eclampsia and toxaemia, unspecified, Prae-eclampsia levis
+∞
131.1
125
*
O10.0
ICD-10 Finland
Pre-existing essential hypertension complicating pregnancy, childbirth and the puerperium
+∞
85.8
82
*
O14.1
ICD-10 Finland
Severe pre-eclampsia
+∞
70.0
67
*
6424A
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Mild or unspecified pre-eclampsia[PRAE-ECLAMPSIA LEVIS, ENNEN SYNNYTYSTÄ]
+∞
65.8
63
*
E66.01
ICD-10 Finland
Obesity due to excess calories
2.9
58.2
399
1512
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
2.1
49.7
652
3444
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
2.5
47.1
419
1835
205
Kela drug reimbursment
Chronic hypertension
2.1
45.3
630
3394
65000
ICD-8 Finland
Delivery without mention of complication, Occipital presentation
1.7
45.2
1342
9403
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
2.5
43.7
392
1720
6423A
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Transient hypertension of pregnancy[HYPERTENSIO GRAVIDARUM, ENNEN SYNNYTYSTÄ]
+∞
42.8
41
*
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
2.2
42.3
461
2226
103
Kela drug reimbursment
Diabetes, insulin-treated
2.0
41.5
651
3666
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.0
41.4
640
3585
Y6099
ICD-8 Finland
Prenatal care and observation
2.7
39.6
296
1173
I10
ICD-10 Finland
Essential (primary) hypertension
1.6
37.0
1435
10639
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
5.8
36.4
106
188
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
1.7
35.9
898
5877
O36.6
ICD-10 Finland
Maternal care for excessive fetal growth
3.3
35.4
187
588
A10BA02
ATC
metformin; oral
1.8
34.7
669
4023
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
2.2
33.5
356
1689
O82.10
ICD-10 Finland
Delivery by emergency caesarean section
2.5
32.3
264
1096
C09AA02
ATC
enalapril; systemic
2.0
32.2
462
2491
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.9
31.4
518
2940
40199
ICD-8 Finland
Essential benign hypertension
8.4
30.9
69
84
C03CA01
ATC
furosemide; systemic
1.8
30.5
597
3591
E66.8
ICD-10 Finland
Other obesity
2.6
30.5
228
901
T90
ICPC
Diabetes non-insulin dependent
1.8
29.9
562
3336
O80.8
ICD-10 Finland
Other single spontaneous delivery
2.8
29.2
203
768
6420X
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Benign essential hypertension complicating pregnancy, childbirth and the puerperium
+∞
29.2
28
*
R80
ICD-10 Finland
Isolated proteinuria
9.8
28.6
58
60
63704
ICD-8 Finland
Pre-eclampsia, eclampsia and toxaemia, unspecified, Prae-eclampsia gravis
+∞
28.2
27
*
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
1.8
28.1
601
3710
C07AG01
ATC
labetalol; systemic
12.7
28.0
50
40
W84
ICPC
Pregnancy high risk
3.1
27.9
160
534
SPAT1249
SPAT
Treatment-related counselling outside office
1.5
27.3
1309
9973
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.6
27.2
205
814
A10AE04
ATC
insulin glargine; parenteral
2.4
26.7
235
1013
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
2.0
26.6
359
1881
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
2.3
26.4
257
1167
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
2.9
26.2
166
591
A10AE05
ATC
insulin detemir; parenteral
2.9
24.9
159
571
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
2.9
24.2
151
535
63710
ICD-8 Finland
Pre-eclampsia, eclampsia and toxaemia, unspecified, Eclampsia
+∞
24.0
23
*
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
1.7
23.4
554
3507
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.8
23.3
476
2881
Z32.1
ICD-10 Finland
Pregnancy confirmed
1.9
23.2
373
2085
MAA00
NOMESCO Finland
Amniocentesis
3.4
23.1
116
353
63799
ICD-8 Finland
Pre-eclampsia, eclampsia and toxaemia, unspecified, Toxaemia, unspecified
+∞
22.9
22
*
C07AB07
ATC
bisoprolol; oral
1.5
22.0
1132
8639
E66.00
ICD-10 Finland
Metabolic syndrome
2.5
21.4
168
682
N02AX02
ATC
tramadol; systemic, rectal
1.4
20.1
1181
9210
O80.0
ICD-10 Finland
Spontaneous vertex delivery
1.5
20.1
964
7218
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
3.8
19.8
85
229
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.3
19.6
179
788
N02BE01
ATC
paracetamol; systemic, rectal
1.5
18.8
2767
25492
J01DA01
ATC
[U] cefalexin; systemic
1.4
18.5
2000
17320
65700
ICD-8 Finland
Occipital presentation
3.9
18.3
75
194
160
Kela drug reimbursment
exenatide
3.9
18.2
76
200
6424B
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Mild or unspecified pre-eclampsia[PRAE-ECLAMPSIA LEVIS, SYNNYTYKSEN AIKANA]
+∞
17.7
17
*
G56.0
ICD-10 Finland
Carpal tunnel syndrome
1.6
17.6
458
2956
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
17.4
1400
11470
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.5
17.1
811
6021
B01AB05
ATC
enoxaparin; parenteral
1.4
17.0
863
6492
A10BJ06
ATC
semaglutide; parenteral
2.9
17.0
104
365
Z39.2
ICD-10 Finland
Routine postpartum follow-up
1.6
16.9
457
2977
MA1AE
NOMESCO Finland
Ultrasound examination of early pregnancy (before 12. postmenstrual week)
1.7
16.9
366
2244
O12
ICD-10 Finland
Gestational [pregnancy-induced] oedema and proteinuria without hypertension
+∞
16.7
16
*
Z35.9
ICD-10 Finland
Supervision of high-risk pregnancy, unspecified
2.5
16.6
129
521
XMA22
NOMESCO Finland
General examination of pregnant woman
2.0
16.4
217
1124
66180
ICD-8 Finland
Occipital presentation
2.7
16.4
111
416
N39.1
ICD-10 Finland
Persistent proteinuria, unspecified
9.0
16.4
34
38
310
Kela drug reimbursment
Orlistat, sibutramine and other major and expensive medicines used to treat obesity
4.4
16.4
59
136
SPAT1357
SPAT
Monitoring of problem during pregnancy
2.6
16.2
119
467
Z30.2
ICD-10 Finland
Sterilization
1.6
15.8
393
2504
T82
ICPC
Obesity
2.3
15.7
145
643
C08CA01
ATC
amlodipine; oral
1.5
15.7
752
5578
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.5
15.6
665
4816
C09CA01
ATC
losartan; oral
1.5
15.6
564
3942
SPAT1379
SPAT
Health check-up of pregnant person
1.7
15.5
372
2347
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
3.1
15.4
86
286
E66.9
ICD-10 Finland
Obesity, unspecified
2.5
15.2
121
498
63499
ICD-8 Finland
Other complications of pregnancy, Other
2.8
15.0
96
347
A10BH01
ATC
sitagliptin; oral
2.0
15.0
200
1043
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
1.7
14.8
359
2268
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.6
14.7
448
3005
SPAT1196
SPAT
Monitoring of normal pregnancy
1.8
14.6
259
1490
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
3.4
14.5
69
204
MAC96
NOMESCO Finland
Other induction or advancement of labour
2.6
14.5
106
416
O16
ICD-10 Finland
Unspecified maternal hypertension
27.3
14.3
19
7
MAC10
NOMESCO Finland
Antepartum dilatation of cervical canal
2.9
14.2
85
296
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
14.2
1131
9157
SPAT1262
SPAT
Handing over of treatment supplies
1.6
14.2
418
2782
P01AB01
ATC
metronidazole; oral, rectal
1.3
14.2
1364
11379
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.3
13.8
1661
14302
J01DB01
ATC
cefalexin; oral
1.4
13.7
2579
23780
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.4
13.6
794
6087
O61.0
ICD-10 Finland
Failed medical induction of labour
4.1
13.6
52
128
Z34.9
ICD-10 Finland
Supervision of normal pregnancy, unspecified
1.6
13.5
368
2397
K02.1
ICD-10 Finland
Caries of dentine
1.3
13.5
1767
15386
C09BA02
ATC
enalapril and diuretics; systemic
2.1
13.4
160
797
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.6
13.3
385
2545
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
2.3
13.2
117
510
A10BJ02
ATC
liraglutide; parenteral
2.9
13.2
78
271
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.3
13.1
1816
15912
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
1.6
13.0
373
2459
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.0
13.0
172
890
A10BK03
ATC
empagliflozin; oral
2.0
13.0
164
836
J01AA02
ATC
doxycycline; systemic
1.4
13.0
2474
22716
O36.5
ICD-10 Finland
Maternal care for poor fetal growth
2.6
12.8
95
377
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
1.6
12.6
364
2407
Z36.0
ICD-10 Finland
Antenatal screening for chromosomal anomalies
1.9
12.6
187
1016
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.3
12.6
1735
15152
R51.80
ICD-10 Finland
Headache
1.5
12.6
480
3385
WX110
NOMESCO Finland
Local anesthesy
1.3
12.5
2166
19533
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.4
12.3
616
4579
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.3
12.3
1194
9903
G47.3
ICD-10 Finland
Sleep apnoea
1.5
12.3
456
3194
J45.9
ICD-10 Finland
Asthma, unspecified
1.5
12.3
513
3683
C10AA01
ATC
simvastatin; oral
1.4
12.2
877
6944
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
2.6
12.2
91
362
M79.6
ICD-10 Finland
Pain in limb
1.3
12.2
1074
8784
H02AB06
ATC
prednisolone; systemic
1.3
12.0
1337
11296
C09CA06
ATC
candesartan; oral
1.4
12.0
581
4288
M54.5
ICD-10 Finland
Low back pain
1.3
12.0
997
8074
MA2XE
NOMESCO Finland
Other obstetric ultrasound examination
1.8
11.9
225
1324
SPAT1263
SPAT
Sampling
1.3
11.9
1260
10575
O30.0
ICD-10 Finland
Twin pregnancy
2.8
11.9
74
266
O82.0
ICD-10 Finland
Delivery by elective caesarean section
1.9
11.8
163
860
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.4
11.8
860
6818
A10BX07
ATC
[U] liraglutide; parenteral
3.9
11.8
48
126
A12BA01
ATC
potassium chloride; oral
2.6
11.8
83
322
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
2.5
11.8
93
384
O26.88
ICD-10 Finland
Other specified pregnancy-related conditions
3.3
11.7
58
179
W78
ICPC
Pregnancy
1.5
11.7
468
3330
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.3
11.6
1185
9878
C03AA03
ATC
hydrochlorothiazide; oral
1.7
11.5
223
1323
6425B
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Severe pre-eclampsia[PRAE-ECLAMPSIA GRAVIS, SYNNYTYKSEN AIKANA]
+∞
11.5
11
*
O11
ICD-10 Finland
Pre-eclampsia superimposed on chronic hypertension
+∞
11.5
11
*
6425A
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Severe pre-eclampsia[PRAE-ECLAMPSIA GRAVIS, ENNEN SYNNYTYSTÄ]
+∞
11.5
11
*
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.4
11.5
766
5988
J01FF01
ATC
clindamycin; systemic
1.4
11.4
752
5861
A08AB01
ATC
orlistat; oral
4.9
11.4
36
74
C10AA05
ATC
atorvastatin; oral
1.4
11.3
787
6186
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.7
11.3
75
279
C07AB02
ATC
metoprolol; systemic
1.5
11.3
436
3078
H04AA01
ATC
glucagon; nasal, parenteral
2.9
11.3
68
241
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
3.0
11.2
62
207
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
2.7
11.2
78
298
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
11.2
2248
20500
SAA02
NOMESCO Finland
Basic examination of mouth
1.3
11.2
2058
18544
QBJ30
NOMESCO Finland
Correction of abdominal apron
3.9
11.1
44
113
SPAT1197
SPAT
Extensive health check-up of expecting family
1.5
11.1
416
2916
ACC51
NOMESCO Finland
Release of median nerve
1.7
11.1
231
1399
N03AX12
ATC
gabapentin; oral
1.5
11.0
432
3057
Z36.4
ICD-10 Finland
Antenatal screening for fetal growth retardation using ultrasound and other physical methods
3.0
11.0
63
214
WX290
NOMESCO Finland
Other blockade of nerve
1.3
10.7
1356
11602
A10BB12
ATC
glimepiride; oral
2.2
10.7
111
523
162
Kela drug reimbursment
liraglutide
3.7
10.7
45
122
8221
FHL
Sterilization of the laparotomy pathway
2.0
10.7
140
726
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.3
10.7
1499
12999
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
5.4
10.7
31
58
O20.0
ICD-10 Finland
Threatened abortion
2.2
10.7
103
470
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
2.9
10.7
64
226
MBA03
NOMESCO Finland
Curettage of uterus after delivery or abortion
2.1
10.6
119
579
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.4
10.5
495
3634
C09DA01
ATC
losartan and diuretics; oral
1.7
10.4
233
1438
O20.9
ICD-10 Finland
Haemorrhage in early pregnancy, unspecified
2.2
10.4
101
462
63709
ICD-8 Finland
Pre-eclampsia, eclampsia and toxaemia, unspecified, Prae-eclampsia NUD
+∞
10.4
10
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.4
10.3
539
4034
SGA01
NOMESCO Finland
Tooth opening as first aid
1.4
10.2
460
3346
C10AA07
ATC
rosuvastatin; oral
1.4
10.2
564
4263
L03
ICPC
Low back symptom/complaint
1.3
10.1
714
5610
T89
ICPC
Diabetes insulin dependent
2.3
10.1
93
413
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
1.9
10.1
147
792
M54.4
ICD-10 Finland
Lumbago with sciatica
1.4
9.9
489
3615
SGA02
NOMESCO Finland
Opening and dilatation of root canal of tooth
1.5
9.9
341
2343
SPAT1324
SPAT
Screening procedure
1.3
9.8
768
6127
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.3
9.8
808
6496
R03AC02
ATC
salbutamol; inhalant
1.3
9.8
1645
14528
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.4
9.8
487
3606
O24.1
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, non-insulin-dependent
5.0
9.7
30
61
S18
ICPC
Laceration/cut
1.3
9.6
1080
9060
C08CA13
ATC
lercanidipine; oral
1.6
9.6
270
1773
N02AJ06
ATC
codeine and paracetamol; systemic
1.3
9.5
1047
8758
Z87.5
ICD-10 Finland
Personal history of complications of pregnancy, childbirth and the puerperium
3.6
9.5
41
115
SPAT1097
SPAT
Recording of ECG
1.5
9.5
351
2451
MAC40
NOMESCO Finland
Pharmacological induction or advancement of labor
2.7
9.4
62
233
65710
ICD-8 Finland
Occipital presentation
2.3
9.4
87
391
A46
ICD-10 Finland
Erysipelas
1.6
9.4
265
1741
O10.9
ICD-10 Finland
Unspecified pre-existing hypertension complicating pregnancy, childbirth and the puerperium
+∞
9.4
9
*
O99.80
ICD-10 Finland
The fear of childbirth
1.8
9.3
165
953
A10BD07
ATC
metformin and sitagliptin; systemic
2.3
9.3
85
378
EBA00
NOMESCO Finland
Extraction of tooth
1.3
9.3
879
7200
WZA90
NOMESCO Finland
Other doctors statement
1.3
9.3
633
4944
63497
ICD-8 Finland
Other complications of pregnancy, Partus prematurus imminens, alibi non classificabilis
2.0
9.3
120
620
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.5
9.2
284
1906
Z35.2
ICD-10 Finland
Supervision of pregnancy with other poor reproductive or obstetric history
2.5
9.2
71
292
O60
ICD-10 Finland
Preterm labour and delivery
2.2
9.2
95
448
8811
FHL
Cesarean section
1.6
9.1
213
1336
78900
ICD-8 Finland
Abnormal urinary constituents of unspecified cause, Albuminuria
11.5
9.1
16
14
L86
ICPC
Back syndrome with radiating pain
1.8
9.0
159
918
O68.0
ICD-10 Finland
Labour and delivery complicated by fetal heart rate anomaly
1.8
9.0
162
942
O40
ICD-10 Finland
Polyhydramnios
3.0
9.0
48
159
A10BH05
ATC
linagliptin; oral
2.3
8.9
78
342
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.5
8.9
286
1940
N92.1
ICD-10 Finland
Excessive and frequent menstruation with irregular cycle
1.6
8.9
221
1408
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.3
8.9
1125
9563
O41.0
ICD-10 Finland
Oligohydramnios
2.4
8.8
71
299
O26.82
ICD-10 Finland
Exhaustion and fatigue pregnancy-related
2.4
8.8
70
290
J01CA04
ATC
amoxicillin; systemic
1.3
8.8
2571
24137
66120
ICD-8 Finland
Occipital presentation
9.5
8.8
17
18
C02AC05
ATC
moxonidine; oral
2.2
8.7
85
393
A10BX04
ATC
[U] exenatide; parenteral
4.0
8.7
33
83
R75
ICPC
Sinusitis acute/chronic
1.7
8.7
163
958
K04.0
ICD-10 Finland
Pulpitis
1.5
8.7
276
1866
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
3.3
8.6
42
130
C08CA05
ATC
nifedipine; systemic
1.9
8.6
131
718
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
6.1
8.6
22
36
A10BK01
ATC
dapagliflozin; oral
2.1
8.6
93
449
O28.8
ICD-10 Finland
Other abnormal findings on antenatal screening of mother
3.2
8.5
43
137
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
2.4
8.5
71
304
C07AG02
ATC
carvedilol; oral
2.0
8.5
106
545
R02
ICPC
Shortness of breath/dyspnoea
1.5
8.4
299
2070
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
1.6
8.4
205
1298
J01CE02
ATC
phenoxymethylpenicillin; oral
1.2
8.4
2121
19484
R06.0
ICD-10 Finland
Dyspnoea
1.3
8.4
610
4801
SPAT1301
SPAT
No procedures
1.3
8.3
827
6806
K86
ICPC
Hypertension uncomplicated
1.5
8.3
248
1654
R05
ICPC
Cough
1.3
8.2
669
5353
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.2
8.2
1395
12239
A10AE06
ATC
insulin degludec; parenteral
2.3
8.2
72
316
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
3.5
8.1
36
104
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
2.6
8.1
57
224
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.4
8.1
337
2412
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.3
8.1
868
7210
A10BJ01
ATC
exenatide; parenteral
4.2
8.1
29
70
R09
ICPC
Sinus symptom/complaint
1.5
8.1
273
1871
O36.3
ICD-10 Finland
Maternal care for signs of fetal hypoxia
4.0
8.0
30
75
L08
ICPC
Shoulder symptom/complaint
1.4
8.0
501
3850
O24.9
ICD-10 Finland
Diabetes mellitus in pregnancy, unspecified
2.4
8.0
62
256
O21.9
ICD-10 Finland
Vomiting of pregnancy, unspecified
2.9
8.0
46
159
25009
ICD-8 Finland
Diabetes mellitus, Unspecified
5.3
8.0
23
44
C10AX09
ATC
ezetimibe; oral
1.6
8.0
210
1360
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
1.7
7.8
170
1043
Z01.8
ICD-10 Finland
Other specified special examinations
1.3
7.7
581
4592
-1
NOMESCO Finland
NA
1.3
7.7
967
8178
C02EA02
ATC
NA
2.5
7.7
60
247
SPAT1310
SPAT
Counselling related to known health issue
1.3
7.7
893
7484
A10AA02
ATC
NA
2.2
7.5
69
312
N03AX16
ATC
pregabalin; oral
1.3
7.5
640
5149
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.4
7.5
365
2691
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.3
7.5
776
6408
WX306
NOMESCO Finland
Lumbar epidural anesthesy
1.5
7.5
227
1518
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
2.7
7.5
49
186
MAC01
NOMESCO Finland
Rupture of aminiotic membrane for induction of labor
2.4
7.4
58
240
H01
ICPC
Ear pain/earache
1.4
7.4
307
2195
C07AB03
ATC
atenolol; systemic
1.9
7.4
109
594
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.4
7.4
397
2977
B01AC04
ATC
clopidogrel; oral
1.5
7.3
215
1429
V230A
ICD-9 Finland
Supervision of high-risk pregnancy, Pregnancy with history of infertility
2.7
7.3
47
176
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
1.5
7.3
282
1991
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.2
7.3
1108
9570
Z32.0
ICD-10 Finland
Pregnancy, not (yet) confirmed
2.1
7.3
81
398
Z34.0
ICD-10 Finland
Supervision of normal first pregnancy
1.4
7.2
395
2970
SPAT1380
SPAT
Postpartum check-up
1.5
7.2
284
2010
M04AA01
ATC
allopurinol; systemic
1.7
7.2
157
966
KMAK
NOMESCO Finland
NA
1.2
7.2
1631
14683
65300
ICD-8 Finland
Occipital presentation
2.7
7.2
46
170
A03
ICPC
Fever
1.4
7.1
442
3390
66110
ICD-8 Finland
Occipital presentation
3.7
7.1
29
79
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.5
7.1
223
1505
A10AA01
ATC
NA
2.2
7.0
63
283
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.4
7.0
302
2176
SGA03
NOMESCO Finland
Demanding opening and dilatation of root canal of tooth
1.5
7.0
259
1810
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
1.5
7.0
226
1536
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
2.8
7.0
42
152
O82.11
ICD-10 Finland
Childbirth with an emergency caesarean section in an emergency
2.8
7.0
41
146
J45.1
ICD-10 Finland
Nonallergic asthma
1.6
6.8
179
1158
O21.1
ICD-10 Finland
Hyperemesis gravidarum with metabolic disturbance
4.8
6.8
21
44
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.4
6.8
276
1965
R07.4
ICD-10 Finland
Chest pain, unspecified
1.3
6.8
623
5059
C07BB07
ATC
bisoprolol and thiazides; systemic
1.9
6.8
96
517
C09DA06
ATC
candesartan and diuretics; oral
1.6
6.8
151
937
E11
ICD-10 Finland
Type 2 diabetes mellitus
1.4
6.7
283
2031
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.3
6.7
641
5234
EBA10
NOMESCO Finland
Surgical removal of tooth
1.4
6.7
308
2248
SGC00
NOMESCO Finland
Local medication of root channels of tooth
1.4
6.6
286
2062
O36.8
ICD-10 Finland
Maternal care for other specified fetal problems
2.3
6.6
56
242
M01AE03
ATC
ketoprofen; systemic, rectal
1.2
6.6
1023
8827
O03.4
ICD-10 Finland
Spontaneous abortion, Incomplete, without complication
2.0
6.6
76
379
C01DA14
ATC
isosorbide mononitrate; oral
1.6
6.6
159
1007
L03.0
ICD-10 Finland
Cellulitis of finger and toe
1.6
6.6
167
1075
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
1.4
6.6
281
2023
O02.1
ICD-10 Finland
Missed abortion
1.6
6.6
176
1147
O47.1
ICD-10 Finland
False labour at or after 37 completed weeks of gestation
1.7
6.5
119
699
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
1.6
6.5
165
1058
WX307
NOMESCO Finland
Obstetric epidural analgesia
1.5
6.5
246
1726
AN1
HP
Coronary angiography
1.6
6.5
152
954
E66
ICD-10 Finland
Obesity
1.7
6.5
122
724
TPH04
NOMESCO Finland
Cathetrisation of vein
1.3
6.5
475
3738
SPAT1283
SPAT
Restricted health certificate
1.3
6.5
552
4433
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.3
6.4
416
3212
6488A
ICD-9 Finland
Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Abnormal glucose tolerance
2.2
6.4
59
269
XF600
NOMESCO Finland
Bloodpressure measurement
1.7
6.4
130
788
D73
ICPC
Gastroenteritis presumed infection
2.0
6.4
77
392
SPAT1260
SPAT
Consultation of another employee
1.3
6.4
455
3566
MAC00
NOMESCO Finland
Rupture of amniotic membrane
4.7
6.4
20
43
27799
ICD-8 Finland
Obesity not specified as of endocrine origin
4.1
6.4
23
57
H3600, E103
ICD-10 Finland
NA
3.2
6.4
30
93
N71.0
ICD-10 Finland
Acute inflammatory disease of uterus
1.9
6.4
93
509
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.4
6.3
298
2184
L17
ICPC
Foot/toe symptom/complaint
1.3
6.3
661
5452
O23.1
ICD-10 Finland
Infections of bladder in pregnancy
4.6
6.3
20
44
6426A
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Eclampsia[ECLAMPSIA , ENNEN SYNNYTYSTÄ]
+∞
6.2
6
*
A10BD03
ATC
metformin and rosiglitazone; systemic
3.1
6.2
31
100
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.3
6.2
441
3449
M16.1
ICD-10 Finland
Other primary coxarthrosis
1.5
6.2
228
1593
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.2
6.2
1516
13671
SPAT1028
SPAT
Ultrasound examination of paranasal sinuses
1.5
6.2
178
1179
O26.7
ICD-10 Finland
Subluxation of symphysis (pubis) in pregnancy, childbirth and the puerperium
2.8
6.2
36
128
H66.0
ICD-10 Finland
Acute suppurative otitis media
1.6
6.2
167
1091
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.3
6.1
722
6037
R96
ICPC
Asthma
1.4
6.1
238
1680
O03.9
ICD-10 Finland
Spontaneous abortion, Complete or unspecified, without complication
1.6
6.1
135
836
J01MA02
ATC
ciprofloxacin; systemic
1.2
6.1
952
8208
R06.5
ICD-10 Finland
Mouth breathing
1.5
6.1
177
1173
Z30.1
ICD-10 Finland
Insertion of (intrauterine) contraceptive device
1.3
6.1
384
2954
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
3.2
6.1
29
91
O68.3
ICD-10 Finland
Labour and delivery complicated by biochemical evidence of fetal stress
3.6
6.1
25
70
4019X
ICD-9 Finland
Essential hypertension, Unspecified
3.0
6.1
32
108
N04.9
ICD-10 Finland
Nephrotic syndrome, unspecified
6.7
6.0
14
21
O26.6
ICD-10 Finland
Liver disorders in pregnancy, childbirth and the puerperium
2.2
6.0
56
258
O04.9
ICD-10 Finland
Medical abortion, complete or unspecified, without complication
1.4
6.0
280
2046
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.4
6.0
253
1817
Mortality – FinRegistry
↥Association
Association between endpoint O15_GESTAT_OEDEM_PREINUR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| O15_GESTAT_OEDEM_PREINUR | 0.781 [0.61, 1.0] | 0.049 |
| Birth year | 1.0 [0.99, 1.01] | 0.905 |
During the follow-up period (1.1.1998 — 31.12.2019), 76 out of 9505 females with O15_GESTAT_OEDEM_PREINUR died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have O15_GESTAT_OEDEM_PREINUR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.092% | No data |
| 5 | 0.551% | No data |
| 10 | 1.401% | No data |
| 15 | 2.607% | No data |
| 20 | 4.687% | No data |
Relationships between endpoints
↥Index endpoint: O15_GESTAT_OEDEM_PREINUR – Gestational [pregnancy-induced] oedema and proteinuria without hypertension
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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