Risteys · SCND_OTH_KNEEARTHROSIS

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M17.5 Hospital discharge: ICD-9 — 7152F Cause of death: ICD-10 — M17.5 Cause of death: ICD-9 — 7152F 2 out of 7 registries used, show all original rules.	1952
4. Check minimum number of events None	1952
5. Include endpoints None	1952
6. Filter based on genotype QC (FinnGen only)	1952

	All	Female	Male
Number of individuals
Whole population	13147	6589	6446
Only index persons	11182	5819	5363
Unadjusted period prevalence (%)
Whole population	0.18	0.19	0.18
Only index persons	0.21	0.21	0.20
Median age at first event (years)
Whole population	56.46	59.11	53.59
Only index persons	54.68	57.72	51.40

	All	Female	Male
Number of individuals	1952	1030	922
Unadjusted period prevalence (%)	0.38	0.35	0.41
Median age at first event (years)	54.82	56.03	53.48

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
1732: Matched controls
17320

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

7152F

ICD-9 Finland

Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, secondary[OSTEORTHROSIS SECUNDARIA,POLVI]

+∞

323.0

357

NG1AA

NOMESCO Finland

Knee X-ray examination without contrast

24.4

323.0

660

426

M17.5

ICD-10 Finland

Other secondary gonarthrosis

12052.5

323.0

1403

M17.0

ICD-10 Finland

Primary gonarthrosis, bilateral

30.1

323.0

547

261

NGF25

NOMESCO Finland

Operation for osteochondritis of knee, arthroscopic

38.6

323.0

488

174

NJ2MA

NOMESCO Finland

Measurement of mechanical axis of lower leg with X-ray

221.6

323.0

504

NGB20

NOMESCO Finland

Primary total prosthetic replacement of knee joint without patellar part

715.4

323.0

707

M17.1

ICD-10 Finland

Other primary gonarthrosis

74.0

323.0

1024

331

M17.3

ICD-10 Finland

Other post-traumatic gonarthrosis

187.6

289.4

296

NGB40

NOMESCO Finland

Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis

295.9

253.9

253

L15

ICPC

Knee symptom/complaint

6.4

205.9

655

1510

NGD05

NOMESCO Finland

Partial excision of meniscus of knee, arthroscopic

8.8

194.8

460

680

M17.9

ICD-10 Finland

Gonarthrosis, unspecified

10.1

188.2

405

507

M23.2

ICD-10 Finland

Derangement of meniscus due to old tear or injury

9.3

186.0

422

579

B01AB05

ATC

enoxaparin; parenteral

4.7

185.7

878

3096

WX320

NOMESCO Finland

Spinalanesthesy

5.2

182.2

708

2017

L90

ICPC

Osteoarthrosis of knee

17.6

163.2

265

176

1220

FHL

Arthroscopy

14.1

158.8

283

236

7151F

ICD-9 Finland

Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, POLVI]

+∞

145.9

138

Z96.6

ICD-10 Finland

Presence of orthopaedic joint implants

20.7

145.7

222

122

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

5.8

142.6

460

1010

N02AX02

ATC

tramadol; systemic, rectal

3.7

141.5

1029

4928

M09AX01

ATC

hyaluronic acid; parenteral

16.4

138.3

230

160

NGF35

NOMESCO Finland

Plastic operation of joint cartilage of knee

27.6

136.6

190

M01AX05

ATC

glucosamine; oral

4.6

133.0

555

1604

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

8.0

132.5

326

489

M17

ICD-10 Finland

Gonarthrosis [arthrosis of knee]

7.3

130.8

343

566

WX111

NOMESCO Finland

Local infiltration anesthesia

33.7

127.4

168

72410

ICD-8 Finland

Internal derangement of joint, Other shoulder derangement

17.5

124.3

201

129

NG1DA

NOMESCO Finland

X-ray of knees

52.1

123.1

148

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

5.9

122.6

382

789

M05.8

ICD-10 Finland

Other seropositive rheumatoid arthritis

8.3

122.5

291

410

NGA30

NOMESCO Finland

Exploration of knee joint, arthroscopic

14.0

121.5

216

175

T84.0

ICD-10 Finland

Mechanical complication of internal joint prosthesis

14.8

119.2

206

156

L01BA01

ATC

methotrexate; systemic (folic acid analog.)

9.6

107.8

232

274

A07EC01

ATC

sulfasalazine; oral, rectal

5.8

105.8

329

668

M01AH05

ATC

etoricoxib; oral

3.1

105.4

1205

7314

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

3.0

104.1

994

5319

1221

FHL

Arthroscopy and meniscus surgery

15.0

91.9

157

114

P01BA02

ATC

hydroxychloroquine; oral

5.2

89.8

308

692

L04AA13

ATC

leflunomide; oral

11.3

82.3

160

154

313

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)

11.0

78.1

154

152

N02AJ06

ATC

codeine and paracetamol; systemic

2.7

78.1

772

3967

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

5.6

75.2

238

482

NG2CA

NOMESCO Finland

X-ray of patella with specialised projection

158.8

72.6

ZXA00

NOMESCO Finland

Right side

2.8

71.2

623

2934

NG2AA

NOMESCO Finland

Patella X-ray examination

23.5

70.5

102

L88

ICPC

Rheumatoid/seropositive arthritis

7.5

69.9

174

255

M17.4

ICD-10 Finland

Other secondary gonarthrosis, bilateral

246.6

69.8

ZXA05

NOMESCO Finland

Left side

2.8

69.5

586

2690

281

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab

10.6

69.4

139

141

1225

FHL

Arthroscopy and other therapeutic procedure

23.0

68.7

100

NGU20

NOMESCO Finland

Removal of internal fixation device from knee or lower leg

15.1

65.6

111

71301

ICD-8 Finland

Osteo-arthritis and allied conditions, Arthritis (arthrosis) genus

+∞

65.0

N03AX12

ATC

gabapentin; oral

3.3

64.5

382

1373

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

3.8

64.1

308

939

1223

FHL

Arthroscopy and articular cartilage surgery

30.7

63.5

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

2.4

63.3

801

4549

SPAT1153

SPAT

Removal of sutures

2.5

63.2

671

3472

S18

ICPC

Laceration/cut

2.4

61.7

828

4824

M01AH01

ATC

celecoxib; oral (coxibs)

3.0

61.6

435

1761

N02BE01

ATC

paracetamol; systemic, rectal

3.2

61.1

1555

12646

NGC30

NOMESCO Finland

Secondary implantation of prosthesis in knee joint, special prosthesis

318.6

60.7

M23.9

ICD-10 Finland

Internal derangement of knee, unspecified

4.7

59.9

218

510

NG1EA

NOMESCO Finland

Knee X-ray examination with wrench

29.1

57.5

WX002

NOMESCO Finland

Sedation and analgesia

2.8

57.2

457

1987

NGT60

NOMESCO Finland

Forcible manipulation of knee joint

126.4

57.2

B01AF01

ATC

rivaroxaban; oral

3.6

57.1

284

885

H02AB06

ATC

prednisolone; systemic

2.3

56.9

918

5764

NGK30

NOMESCO Finland

Angulation, rotation or displacement osteotomy of knee or lower leg

152.6

56.2

T84.5

ICD-10 Finland

Infection and inflammatory reaction due to internal joint prosthesis

23.9

55.8

M17.2

ICD-10 Finland

Post-traumatic gonarthrosis, bilateral

+∞

55.5

M01AE03

ATC

ketoprofen; systemic, rectal

2.3

55.2

789

4656

M01AH02

ATC

rofecoxib; oral

3.2

54.8

332

1200

M19.0

ICD-10 Finland

Primary arthrosis of other joints

3.9

54.6

250

725

B01AX06

ATC

[U] rivaroxaban; oral

13.5

53.7

NGC20

NOMESCO Finland

Secondary implantation of prosthesis in knee joint, normal prosthesis

+∞

53.4

NH3EA

NOMESCO Finland

Feet X-ray examination with load

9.6

52.5

110

121

9314

FHL

Total knee endoprosthesis (also includes patellar part)

115.7

52.1

M25.5

ICD-10 Finland

Pain in joint

2.4

50.9

558

2863

7170A

ICD-9 Finland

Internal derangement of knee, Old bucket handle tear of medial meniscus

12.9

50.5

M06.0

ICD-10 Finland

Seronegative rheumatoid arthritis

7.4

50.3

124

178

S83.2

ICD-10 Finland

Tear of meniscus, current

4.6

49.6

184

436

M79.6

ICD-10 Finland

Pain in limb

2.2

49.2

686

3937

TNG10

NOMESCO Finland

Puncture of knee

19.5

49.1

NGF15

NOMESCO Finland

Total synovectomy of knee, arthroscopic

24.7

48.7

NG1AE

NOMESCO Finland

Knee joint ultrasound exmination

23.5

48.7

9312

FHL

Osteotomy of tibia or femur

491.1

48.6

Y88.3

ICD-10 Finland

Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

7.7

48.5

116

159

NGC00

NOMESCO Finland

Exchange of a loose part of prosthesis in knee joint

+∞

48.1

N03AX16

ATC

pregabalin; oral

2.4

47.6

489

2408

M01AC06

ATC

meloxicam; systemic, rectal

2.2

46.9

713

4230

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.1

46.8

852

5464

A02BC02

ATC

pantoprazole; systemic

2.1

46.8

1194

8822

S83.5

ICD-10 Finland

Sprain and strain involving (anterior)(posterior) cruciate ligament of knee

7.3

46.4

115

166

X59

ICD-10 Finland

Exposure to unspecified factor

2.6

46.1

387

1702

NGF20

NOMESCO Finland

Operation for osteochondritis of knee, open

164.4

46.0

M05.9

ICD-10 Finland

Seropositive rheumatoid arthritis, unspecified

7.7

45.6

109

149

L04AB04

ATC

adalimumab; parenteral

10.3

45.2

M06.9

ICD-10 Finland

Rheumatoid arthritis, unspecified

6.5

44.4

120

196

A02BC01

ATC

omeprazole; systemic

2.2

42.1

552

3032

ND2AA

NOMESCO Finland

Hand and fingers X-ray examination

3.4

41.5

222

723

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

2.2

41.3

552

3051

84400

ICD-8 Finland

Sprains and strains of knee and leg

10.7

40.7

M13.9

ICD-10 Finland

Arthritis, unspecified

3.7

40.5

191

562

NG1CG

NOMESCO Finland

Knee and lower leg extensive MRI examination with high intensity magnet

14.0

40.5

M01CB01

ATC

sodium aurothiomalate; parenteral

9.7

40.2

ZXM10

NOMESCO Finland

Intraoperative use of conventional X-ray imaging

4.2

40.0

163

421

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

3.1

39.8

248

898

L04AB01

ATC

etanercept; parenteral

11.1

39.5

M16.1

ICD-10 Finland

Other primary coxarthrosis

3.0

39.5

251

921

M01AB05

ATC

diclofenac; systemic, rectal

2.0

39.3

1191

9065

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

2.5

39.1

364

1680

Y83

ICD-10 Finland

Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

3.6

39.1

193

589

E883A

ICD-9 Finland

Fall into hole or other opening in surface

4.2

37.9

153

392

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

2.5

37.9

337

1515

WZA00

NOMESCO Finland

Short statement of of health and health related matters

4.4

37.7

145

354

1222

FHL

Arthroscopy and synovial surgery

14.4

37.6

M01AX17

ATC

nimesulide; oral

2.2

37.1

493

2691

NGB30

NOMESCO Finland

Primary total prosthetic replacement of knee joint without patellar part - connected prosthesis

194.1

36.9

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

3.3

36.8

205

685

NG1BG

NOMESCO Finland

Knee and lower leg MRI examination with high intensity magnet

6.0

36.7

104

181

TPH04

NOMESCO Finland

Cathetrisation of vein

2.2

36.0

424

2188

WZA90

NOMESCO Finland

Other doctors statement

2.2

36.0

425

2193

J01DB01

ATC

cefalexin; oral

2.1

36.0

1410

11637

PH2AE

NOMESCO Finland

Ultrasound examination of lower leg veins

2.8

35.7

249

968

9255

FHL

Joint auger removal

18.3

35.5

NGE35

NOMESCO Finland

Plastic repair of ligament of knee not using prosthetic material, anterior cruciate, arthroscopic

8.6

35.4

M48.0

ICD-10 Finland

Spinal stenosis

2.7

34.7

260

1054

8442A

ICD-9 Finland

Sprains and strains of knee and leg, Cruciate ligament of knee[DISTORSIO/DISTEN/RUPT.LIG.CRUCIATI ANTERIORIS GENUS]

20.2

34.1

B01AB04

ATC

dalteparin; parenteral

4.2

33.7

135

343

M75.1

ICD-10 Finland

Rotator cuff syndrome

2.1

32.8

460

2549

9254

FHL

Arthrotomy (includes biopsy, revision, loose removal, fixation, and similar procedures)

16.0

32.6

7140A

ICD-9 Finland

Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]

9.4

32.5

9243

FHL

Plastic of the patella and its tendons

12.5

32.1

A02BC05

ATC

esomeprazole; systemic

1.9

31.9

734

4894

G56.0

ICD-10 Finland

Carpal tunnel syndrome

2.6

31.9

268

1158

WX212

NOMESCO Finland

Femoral plexus blockade

8.4

31.7

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

1.9

31.6

622

3923

TND11

NOMESCO Finland

Injection of diagnostic or therapeutic substance in joint, wrist or hand

9.9

31.5

TNG11

NOMESCO Finland

Injection of diagnostic or therapeutic substance in knee

16.0

30.8

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

1.9

30.4

546

3316

NA1EA

NOMESCO Finland

Cervical spine X-ray examination with flexion

8.8

30.3

L40.5

ICD-10 Finland

Arthropathic psoriasis

8.0

30.1

M07.3*L40.5

ICD-10 Finland

Other psoriatic arthropathies

6.2

30.0

140

NGB10

NOMESCO Finland

Primary partial prosthetic replacement of knee joint, demi prosthesis

69.2

30.0

M01AE02

ATC

naproxen; oral, rectal

1.8

29.7

955

7058

M02AA07

ATC

piroxicam; topical

1.8

29.3

677

4485

NB1AA

NOMESCO Finland

Shoulder X-ray examination without contrast

3.3

28.8

157

515

L28

ICPC

Limited function/disability (L)

2.3

28.6

301

1455

N02AA05

ATC

oxycodone; systemic

2.4

28.6

278

1293

9057A

ICD-9 Finland

Late effects of musculoskeletal and connective tissue injuries, Late effect of sprain and strain without mention of tendon injury

17.1

28.5

Y83.1

ICD-10 Finland

Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

10.0

28.3

SAA02

NOMESCO Finland

Basic examination of mouth

1.8

28.1

1023

7795

9244

FHL

Plastic or reconstruction of ligaments of the knee other than the lumbar region

39.7

28.1

SPAT1202

SPAT

Intra-articular injection

5.3

28.0

174

WX306

NOMESCO Finland

Lumbar epidural anesthesy

4.0

28.0

117

309

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

2.7

28.0

201

789

WX702

NOMESCO Finland

Supraglottic ventilation device

3.6

27.9

132

387

NF1AA

NOMESCO Finland

Hip X-ray examination

2.8

27.9

191

729

E8859

ICD-8 Finland

Fall on same level from slipping, stumbling or tripping

4.5

27.9

102

237

NFB30

NOMESCO Finland

Primary total prosthetic replacement of hip joint not using cement

3.2

27.9

154

509

WX408

NOMESCO Finland

General anesthesy, balanced

1.9

27.7

497

3000

M15.9

ICD-10 Finland

Polyarthrosis, unspecified

3.8

27.0

119

329

WX110

NOMESCO Finland

Local anesthesy

1.8

27.0

1137

9011

ND2BA

NOMESCO Finland

Hand and fingers extensive X-ray examination

5.8

26.8

137

L17

ICPC

Foot/toe symptom/complaint

1.9

26.3

440

2578

S83.6

ICD-10 Finland

Sprain and strain of other and unspecified parts of knee

4.1

26.3

106

271

7174A

ICD-9 Finland

Internal derangement of knee, Derangement of lateral meniscus

20.4

25.7

TNH11

NOMESCO Finland

Injection of diagnostic or therapeutic substance in ankle joint or foot joint

9.7

25.5

NGC99

NOMESCO Finland

Other secondary prosthetic replacement inknee joint, other or unspecified

+∞

25.1

NGC60

NOMESCO Finland

Exchange or addition of patellar part

+∞

25.1

NG1BA

NOMESCO Finland

Knee extensive X-ray examination

7.7

24.7

M23.5

ICD-10 Finland

Chronic instability of knee

16.6

24.5

NG1AD

NOMESCO Finland

Knee CT examination

10.5

24.1

M19.2

ICD-10 Finland

Other secondary arthrosis

8.6

23.9

X58

ICD-10 Finland

Exposure to other specified factors

2.3

23.8

252

1216

R4110

NOMESCO Finland

Physiotherapy

1.8

23.6

481

3002

M16.0

ICD-10 Finland

Primary coxarthrosis, bilateral

3.0

23.6

140

486

NB1AE

NOMESCO Finland

Shoulder ultrasound examination

6.5

23.4

9311

FHL

Knee cleansing surgery (synovectomy, debridement)

47.4

23.4

M15.0

ICD-10 Finland

Primary generalized (osteo)arthrosis

5.1

23.3

153

M23.4

ICD-10 Finland

Loose body in knee

28.7

23.2

NHG80

NOMESCO Finland

Fusion of first tarsometatarsal joint

4.1

23.1

233

J01FF01

ATC

clindamycin; systemic

1.8

22.8

479

3018

NGF40

NOMESCO Finland

Repair of defect of cartilage in the knee joint with transplant

84.6

22.7

NH1AA

NOMESCO Finland

Ankle X-ray examination without contrast

2.9

22.2

141

511

M25.0

ICD-10 Finland

Haemarthrosis

11.0

22.2

M79.0

ICD-10 Finland

Rheumatism, unspecified

4.0

22.2

237

TNB11

NOMESCO Finland

Injection of diagnostic or therapeutic substance in shoulder joint

12.0

22.0

9165

FHL

Removal of osteosynthesis material

5.3

21.9

133

M16.7

ICD-10 Finland

Other secondary coxarthrosis

12.4

21.8

M01AE01

ATC

ibuprofen; systemic, rectal

1.9

21.8

1493

13227

NGS10

NOMESCO Finland

Incision and debridement of infection of knee joint

39.2

21.7

NGE10

NOMESCO Finland

Incision or suture of capsule of knee joint

20.3

21.7

M07.3

ICD-10 Finland

Other psoriatic arthropathies

7.7

21.4

N06AA09

ATC

amitriptyline; systemic

2.3

21.4

207

952

M93.2

ICD-10 Finland

Osteochondritis dissecans

26.8

21.4

L04AB06

ATC

golimumab; parenteral

14.1

21.3

NA1AA

NOMESCO Finland

Cervical spine X-ray examination without contrast

3.8

21.3

256

R06.0

ICD-10 Finland

Dyspnoea

1.8

21.2

427

2641

M19.9

ICD-10 Finland

Arthrosis, unspecified

4.1

21.2

212

M01AH03

ATC

valdecoxib; oral

2.8

21.0

139

517

NK4AT

NOMESCO Finland

Puncture of joint with ultrasound guidance not elsewher classified

13.6

21.0

ACC59

NOMESCO Finland

Decompression and freeing of adhesions of peripheral nerve: other or unspecified

3.3

21.0

110

350

NE1AA

NOMESCO Finland

Pelvis X-ray examination

2.9

20.9

135

495

8360A

ICD-9 Finland

Dislocation of knee, Tear of medial cartilage or meniscus of knee, current

10.2

20.9

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

1.7

20.7

491

3198

J01DA01

ATC

[U] cefalexin; systemic

1.6

20.5

1036

8295

WX404

NOMESCO Finland

Intravenous generell anesthesy

1.9

20.5

359

2115

M54.5

ICD-10 Finland

Low back pain

1.7

20.4

517

3432

7177A

ICD-9 Finland

Internal derangement of knee, Chondromalacia of patella

7.8

20.4

C03CA01

ATC

furosemide; systemic

1.7

20.4

480

3116

M22.4

ICD-10 Finland

Chondromalacia patellae

4.8

20.3

145

TNX33

NOMESCO Finland

Custom moulded cast, unspecified region

3.1

20.2

114

381

N02AC04

ATC

dextropropoxyphene; oral

3.5

20.1

279

L04AA01

ATC

[U] ciclosporin; systemic

5.7

20.0

105

NHG20

NOMESCO Finland

Fusion of talocrural joint

19.1

20.0

WX720

NOMESCO Finland

Own respiration

3.6

19.9

261

NH3FA

NOMESCO Finland

Weight-bearing X-ray of foot

7.0

19.8

M03BX02

ATC

tizanidine; oral

1.6

19.8

1022

8195

E66.01

ICD-10 Finland

Obesity due to excess calories

2.7

19.6

139

540

S80.0

ICD-10 Finland

Contusion of knee

3.0

19.6

118

414

WX402

NOMESCO Finland

General anaesthesia

2.0

19.6

294

1634

NBG15

NOMESCO Finland

Acromioplastia, arthroscopic

2.7

19.6

136

523

L04AA11

ATC

[U] etanercept; parenteral

17.9

19.6

M23.3

ICD-10 Finland

Other meniscus derangements

8.6

19.4

M23.8

ICD-10 Finland

Other internal derangements of knee

4.3

19.4

171

1224

FHL

Arthroscopy and loose removal

46.5

19.2

7178C

ICD-9 Finland

Internal derangement of knee, Other internal derangement of knee[LAESIO LIGAMENTI CRUCIATI]

22.8

19.1

M19.1

ICD-10 Finland

Post-traumatic arthrosis of other joints

4.3

19.1

174

R4120

NOMESCO Finland

Occupational therapy

2.8

19.0

129

489

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

2.3

18.7

177

804

M00.9

ICD-10 Finland

Pyogenic arthritis, unspecified

7.8

18.4

M71.2

ICD-10 Finland

Synovial cyst of popliteal space [Baker]

4.0

18.3

196

9054A

ICD-9 Finland

Late effects of musculoskeletal and connective tissue injuries, Late effect of fracture of lower extremities

10.5

18.2

S83.0

ICD-10 Finland

Dislocation of patella

9.4

18.1

WX725

NOMESCO Finland

Noninvasive ventilation

3.1

18.1

103

348

J04AB02

ATC

rifampicin; systemic

7.5

18.0

71239

ICD-8 Finland

Rheumatoid arthritis and allied conditions, Arthritis rheumatoides NUD

8.8

17.9

NGU00

NOMESCO Finland

Removal of partial prosthesis from knee joint, other or unspecified

+∞

17.7

E929A

ICD-9 Finland

Late effects of accidental injury[YLIRASITUS JA KESTOKYVYN YLIT LIIKK AIH TAPAT]

9.0

17.7

L08

ICPC

Shoulder symptom/complaint

1.8

17.7

320

1898

ACC51

NOMESCO Finland

Release of median nerve

2.6

17.6

133

535

7327A

ICD-9 Finland

Osteochondropathies, Osteochondritis dissecans[OSTEOCHONDRITIS DISSECANS GENUS]

29.1

17.4

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

1.6

17.4

672

4949

B01AB10

ATC

tinzaparin; parenteral

2.5

17.4

139

579

NHG22

NOMESCO Finland

Fusion of subtalar joint

14.0

17.3

M51.1

ICD-10 Finland

Lumbar and other intervertebral disc disorders with radiculopathy

2.0

17.2

243

1315

I10

ICD-10 Finland

Essential (primary) hypertension

1.5

17.2

983

7941

M47.2

ICD-10 Finland

Other spondylosis with radiculopathy

2.7

17.2

121

468

M01AX01

ATC

nabumetone; oral

3.1

17.2

310

M01AB55

ATC

diclofenac, combinations; oral

2.5

17.1

140

591

NHG76

NOMESCO Finland

Arthroplasty of other tarsometatarsal joint

5.9

16.8

71238

ICD-8 Finland

Rheumatoid arthritis and allied conditions, Arthritis rheumatoides alia definita

7.3

16.8

S89.9

ICD-10 Finland

Unspecified injury of lower leg

3.9

16.8

181

7110F

ICD-9 Finland

Arthropathy associated with infections, Pyogenic arthritis[ARTHRITIS PURULENTA, POLVI]

+∞

16.7

NH1AE

NOMESCO Finland

Ankle joint ultrasound examination

9.3

16.7

ABC36

NOMESCO Finland

Decompression of lumbar nerve roots

3.0

16.6

340

NF1AE

NOMESCO Finland

Hip joint ultrasound examination

4.3

16.6

149

NGF00

NOMESCO Finland

Excision of plica of synovy of knee

5.9

16.5

RF210

NOMESCO Finland

4.0

16.5

174

NHG24

NOMESCO Finland

Fusion of subtalar joint and between bones of ankle

10.9

16.5

NG1AA

SPAT

3.5

16.4

232

SPAT1229

SPAT

Assessment of need for aid

2.4

16.4

149

663

M02AA10

ATC

ketoprofen; topical

1.9

16.3

270

1545

WX704

NOMESCO Finland

Intubation

2.4

16.1

140

610

L04AB05

ATC

certolizumab pegol; parenteral

16.9

16.1

SPAT1263

SPAT

Sampling

1.6

16.0

669

4994

L03

ICPC

Low back symptom/complaint

1.7

15.9

370

2367

Z01.2

ICD-10 Finland

Dental examination

1.6

15.8

611

4471

SPAT1204

SPAT

Arthrocentesis

11.3

15.8

J01AA02

ATC

doxycycline; systemic

1.6

15.7

1300

11333

L04AA17

ATC

[U] adalimumab; parenteral

15.8

15.7

9232

FHL

Knee ligament and / or capsule injury repair surgery

10.5

15.7

M03BC01

ATC

orphenadrine (citrate); systemic

1.7

15.7

367

2350

WZB00

NOMESCO Finland

Telephone receipt or other advice

1.7

15.7

430

2878

M01CB03

ATC

auranofin; oral

7.6

15.7

N06AX21

ATC

duloxetine; oral

2.1

15.7

181

902

NGB50

NOMESCO Finland

Primary total prosthetic replacement of knee joint with patellar part - connected prosthesis

161.4

15.5

S46.0

ICD-10 Finland

Injury of muscle(s) and tendon(s) of the rotator cuff of shoulder

2.2

15.5

156

730

NHU20

NOMESCO Finland

Removal of internal fixation device from ankle or foot

3.0

15.5

304

S83.3

ICD-10 Finland

Tear of articular cartilage of knee, current

7.1

15.4

E66.8

ICD-10 Finland

Other obesity

3.0

15.3

301

NH1EA

NOMESCO Finland

Ankle X-ray examination with load or wrench

16.2

15.2

M22.0

ICD-10 Finland

Recurrent dislocation of patella

10.5

15.2

72221

ICD-8 Finland

Osteochondrosis, Dissecans

17.9

15.2

J01FA10

ATC

azithromycin; systemic

1.5

15.1

889

7140

TNC11

NOMESCO Finland

Injection of diagnostic or therapeutic substance in elbow joint

20.2

15.1

L13

ICPC

Hip symptom/complaint

1.9

15.1

256

1477

NH3BA

NOMESCO Finland

Foot and toes extensive X-ray examination

3.2

15.0

260

M15

ICD-10 Finland

Polyarthrosis

3.1

14.9

287

SPAT1148

SPAT

Treatment of chronic ulcer or burn

1.9

14.9

232

1296

A02BA02

ATC

ranitidine; systemic

1.7

14.8

338

2145

NF1DA

NOMESCO Finland

X-ray of hips

4.1

14.8

142

W19

ICD-10 Finland

Unspecified fall

2.1

14.7

167

823

NF2AT

NOMESCO Finland

Injection to hip joint with ultrasound guidance

13.3

14.7

R03AC02

ATC

salbutamol; inhalant

1.5

14.5

803

6344

TNX50

NOMESCO Finland

Removal of cutom molded cast and internal stretch

2.8

14.5

365

SPAT1301

SPAT

No procedures

1.6

14.5

502

3562

NK5AT

NOMESCO Finland

Joint injection with ultrasound guidance not elsewhere classified

10.1

14.5

M05

ICD-10 Finland

Seropositive rheumatoid arthritis

7.9

14.3

7183F

ICD-9 Finland

Other derangement of joint, Recurrent dislocation of joint[LUXATIO HABITUALIS, POLVI]

17.1

14.3

9294

FHL

Endoprosthesis replacement of the entire hip joint (eg Charnley)

9.2

14.2

WX204

NOMESCO Finland

Axillary plexus blockaced

3.3

14.2

220

J01DA09

ATC

[U] cefadroxil; inhalant, oral

1.6

14.2

430

2948

SAA01

NOMESCO Finland

Simple examination of mouth

1.5

14.1

1083

9145

H02AB04

ATC

methylprednisolone; systemic

1.8

14.1

248

1446

EB1AA

NOMESCO Finland

Tooth X-ray examination

1.5

14.1

863

6949

TPH07

NOMESCO Finland

Cathetrisation of artery

2.0

14.0

189

999

SPAT1149

SPAT

Suture or treatment of traumatic wound

1.9

13.9

215

1198

J01MA12

ATC

levofloxacin; systemic

1.7

13.9

308

1935

S83.4

ICD-10 Finland

Sprain and strain involving (fibular)(tibial) collateral ligament of knee

3.5

13.8

187

X50

ICD-10 Finland

Overexertion and strenuous or repetitive movements

4.4

13.8

113

M54.4

ICD-10 Finland

Lumbago with sciatica

1.8

13.8

254

1504

TNX00

NOMESCO Finland

Puncture and needle biopsy of soft tissue, unspecified region

4.6

13.8

104

A02BC03

ATC

lansoprazole; oral

1.6

13.8

487

3464

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

2.3

13.7

127

570

7140B

ICD-9 Finland

Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SERONEGATIVA]

10.5

13.7

L04AA24

ATC

abatacept; parenteral

12.1

13.6

J01CA04

ATC

amoxicillin; systemic

1.5

13.6

1270

11140

SPAT1256

SPAT

Intramuscular and subcutaneous injection

1.5

13.5

669

5132

7152E

ICD-9 Finland

Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, secondary[OSTEORTHROSIS SECUNDARIA,LONKKANIVEL]

34.3

13.5

NGE15

NOMESCO Finland

Incision fo capsule of knee joint, arthroscopic

34.3

13.5

M01AB01

ATC

indometacin; systemic, rectal

2.2

13.5

145

698

NF1BA

NOMESCO Finland

Hip extensive X-ray examination

3.4

13.4

197

SPAT1253

SPAT

Initiation, adjustment, discontinuation or repetition of medication

1.6

13.4

465

3288

NB1BA

NOMESCO Finland

Shoulder extensive X-ray examination without contrast

3.3

13.4

208

R51.80

ICD-10 Finland

Headache

1.9

13.4

216

1222

NK4EA

NOMESCO Finland

Joint X-ray examintion with load or wrench not elsewhere classified

18.4

13.4

WZA10

NOMESCO Finland

Long statement of health and health related matters

5.3

13.3

L04AX01

ATC

azathioprine; systemic

2.8

13.3

317

L12

ICPC

Hand/finger symptom/complaint

1.9

13.3

217

1233

M70.6

ICD-10 Finland

Trochanteric bursitis

1.9

13.3

195

1067

B01AX05

ATC

fondaparinux; parenteral

10.5

13.2

S72.4

ICD-10 Finland

Fracture of lower end of femur

9.8

13.2

A28

ICPC

Limited function/disability NOS

1.8

13.2

241

1423

E889A

ICD-9 Finland

OTHER OR MORE SPECIFIED FALLING OR FALLING

5.9

13.2

M25.4

ICD-10 Finland

Effusion of joint

5.7

13.2

Z50.1

ICD-10 Finland

Other physical therapy

2.5

13.1

103

426

H02BX01

ATC

methylprednisolone, combinations; systemic

2.6

13.0

391

ND2DA

NOMESCO Finland

Bilateral hand X-ray examination

4.0

13.0

130

M51.3

ICD-10 Finland

Other specified intervertebral disc degeneration

2.2

12.9

132

624

M16.6

ICD-10 Finland

Other secondary coxarthrosis, bilateral

50.4

12.8

W00

ICD-10 Finland

Fall on same level involving ice and snow

1.9

12.8

182

986

NDL52

NOMESCO Finland

Tenosynovectomy of hand

10.6

12.7

J01FA06

ATC

roxithromycin; oral

1.5

12.7

641

4919

NDG60

NOMESCO Finland

Arthroplasty of first CMC joint

5.5

12.7

J01MA02

ATC

ciprofloxacin; systemic

1.5

12.7

612

4649

SFA10

NOMESCO Finland

Fillning on one surface of tooth

1.5

12.5

795

6386

NGB60

NOMESCO Finland

Primary partial prosthetic replacement of knee joint, patellar and femoral part

+∞

12.5

J01CR02

ATC

amoxicillin and beta-lactamase inhibitor; systemic

1.5

12.5

768

6134

9256

FHL

Synovectomy (knee 9311)

20.2

12.5

8361A

ICD-9 Finland

Dislocation of knee, Tear of lateral cartilage or meniscus of knee, current

20.2

12.5

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

1.8

12.4

250

1522

NFC20

NOMESCO Finland

Secondary implantation of hip prosthesis

5.0

12.4

UJF32

NOMESCO Finland

Coloscopy

1.6

12.3

416

2913

R5110

NOMESCO Finland

Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it

1.9

12.2

203

1159

XX9XE

NOMESCO Finland

Other ultrasound examination

6.8

12.2

M79.7

ICD-10 Finland

Fibromyalgia

3.3

12.1

191

9253

FHL

Manipulation under anesthesia or regression and plastering

8.7

12.0

B01AE07

ATC

dabigatran etexilate; oral

2.9

12.0

266

SFA20

NOMESCO Finland

Filling on two surfaces of tooth

1.4

11.9

862

7080

M01AE11

ATC

tiaprofenic acid; oral, rectal

2.7

11.9

298

9112

FHL

Correction osteotomy due to bone shape or positional defect

47.0

11.9

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

2.2

11.8

124

590

NBG00

NOMESCO Finland

Plastic operation on acromioclavicular joint

4.4

11.8

M47.9

ICD-10 Finland

Spondylosis, unspecified

3.1

11.8

218

NDG30

NOMESCO Finland

Fusion of wrist, total

9.0

11.7

R01BA52

ATC

pseudoephedrine, combinations; oral

1.5

11.7

486

3565

M01AB16

ATC

aceclofenac; oral

2.8

11.7

265

L20

ICPC

Joint symptom/complaint NOS

3.1

11.7

208

83600

ICD-8 Finland

Dislocation of knee, Patellae, Non complicata (sive NUD)

16.5

11.7

H02AB07

ATC

prednisone; oral

1.7

11.6

235

1430

SPAT1325

SPAT

Vaccination

1.5

11.6

517

3848

C03EA01

ATC

hydrochlorothiazide and potassium-sparing agents; oral

1.7

11.6

256

1601

NC1AA

NOMESCO Finland

Elbow X-ray examination without contrast

3.1

11.6

209

L01CB

ATC

Podophyllotoxin derivatives

19.1

11.6

K02.1

ICD-10 Finland

Caries of dentine

1.4

11.4

832

6817

D07AC01

ATC

betamethasone; topical

1.5

11.4

540

4066

Z50.9

ICD-10 Finland

Care involving use of rehabilitation procedure, unspecified

2.7

11.4

288

M87.0

ICD-10 Finland

Idiopathic aseptic necrosis of bone

7.9

11.4

Y88.1

ICD-10 Finland

Sequelae of misadventures to patients during surgical and medical procedures

6.1

11.4

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

1.5

11.3

501

3723

A46

ICD-10 Finland

Erysipelas

1.7

11.3

227

1377

83690

ICD-8 Finland

Dislocation of knee, Patellae, Sequelae

35.3

11.3

9251

FHL

Drainage or flushing of the joint under anesthesia

35.3

11.3

8448A

ICD-9 Finland

Sprains and strains of knee and leg, Other specified sites of knee and leg[DISTORSIO/DISTENSIO/RUPT.LIGAMENTI GENUS MULTIPLEX]

35.3

11.3

ZXA10

NOMESCO Finland

Bilateral

1.6

11.1

291

1906

M47.82

ICD-10 Finland

Other spondylosis, cervical region

2.7

11.1

286

AA1AD

NOMESCO Finland

CT of head and brain

1.6

11.1

375

2618

WX400

NOMESCO Finland

Inhalation anesthesy

2.7

11.1

280

NHG77

NOMESCO Finland

Arthroplasty of interphalangeal tarsal joint(s)

3.7

11.0

130

K08.1

ICD-10 Finland

Loss of teeth due to accident, extraction or local periodontal disease

1.9

11.0

177

1002

SPAT1260

SPAT

Consultation of another employee

1.6

10.9

274

1774

7176A

ICD-9 Finland

Internal derangement of knee, Loose body in knee

43.6

10.9

R03BA05

ATC

fluticasone; inhalant

1.6

10.9

275

1781

L16

ICPC

Ankle symptom/complaint

2.0

10.9

148

787

J18.9

ICD-10 Finland

Pneumonia, unspecified

1.6

10.8

361

2512

7148X

ICD-9 Finland

Rheumatoid arthritis and other inflammatory polyarthropathies, Other specified inflammatory polyarthropathies

17.9

10.7

A06AD11

ATC

lactulose; oral

1.7

10.6

223

1372

XX3DW

NOMESCO Finland

Time consuming IT work

1.9

10.6

172

974

NFJ62

NOMESCO Finland

Internal fixation of fracture of other parts of femur with plate

7.0

10.6

J20.9

ICD-10 Finland

Acute bronchitis, unspecified

1.6

10.5

259

1668

WX290

NOMESCO Finland

Other blockade of nerve

1.4

10.5

616

4826

NA1BG

NOMESCO Finland

Cervical spine MRI examination with high intensity magnet

2.3

10.4

406

R05

ICPC

Cough

1.6

10.4

319

2171

R06AE07

ATC

cetirizine; oral

1.4

10.4

629

4953

R60.0

ICD-10 Finland

Localized oedema

1.8

10.4

175

1003

9531

FHL

Arthrodesis of the hand joint

12.1

10.3

3006

Kela drug reimbursment

Baricitinib

32.7

10.3

L04AA37

ATC

baricitinib; oral

32.7

10.3

NH1AD

NOMESCO Finland

Ankle and foot CT

3.6

10.3

127

S82.1

ICD-10 Finland

Fracture of upper end of tibia

4.0

10.3

102

V49.9

ICD-10 Finland

Car occupant [any] injured in unspecified traffic accident

2.8

10.3

231

M46.9

ICD-10 Finland

Inflammatory spondylopathy, unspecified

5.8

10.3

M15.3

ICD-10 Finland

Secondary multiple arthrosis

18.9

10.3

8448X

ICD-9 Finland

Sprains and strains of knee and leg, Other specified sites of knee and leg[DISTORSIO/DISTEN/RUPTURA GENUS ET CRURIS ALIA DEFIN]

9.6

10.3

NDU20

NOMESCO Finland

Removal of internal fixation device from wrist or hand

3.4

10.2

149

NH3DA

NOMESCO Finland

Bilateral foot X-ray examination

3.4

10.2

149

E0000UV

ATC

1.4

10.2

578

4488

N06AX11

ATC

mirtazapine; oral

1.5

10.2

475

3549

G56.2

ICD-10 Finland

Lesion of ulnar nerve

2.9

10.2

226

M13.1

ICD-10 Finland

Monoarthritis, not elsewhere classified

6.3

10.2

M75.4

ICD-10 Finland

Impingement syndrome of shoulder

2.1

10.1

117

583

Z87.1

ICD-10 Finland

Personal history of diseases of the digestive system

1.4

10.1

675

5407

TQW40

NOMESCO Finland

Remowal of suture of skin

2.0

10.1

123

627

M13.0

ICD-10 Finland

Polyarthritis, unspecified

4.5

10.1

D07AB02

ATC

hydrocortisone butyrate; topical

1.5

10.1

413

3007

NHL99

NOMESCO Finland

Other operation on muscle or tendon of ankle or foot

8.5

10.0

J45.9

ICD-10 Finland

Asthma, unspecified

1.6

10.0

265

1736

Z01.8

ICD-10 Finland

Other specified special examinations

1.6

10.0

322

2214

NH1FA

NOMESCO Finland

Weight-bearing X-ray of ankle

6.5

10.0

M06.8

ICD-10 Finland

Other specified rheumatoid arthritis

6.5

10.0

L91

ICPC

Osteoarthrosis other

4.4

10.0

NA1AD

NOMESCO Finland

Cervical spine CT examination

2.6

10.0

279

Z71.3

ICD-10 Finland

Dietary counselling and surveillance

2.5

10.0

315

NG4AA

NOMESCO Finland

Lower leg X-ray examination

3.1

10.0

180

293

Kela drug reimbursment

Baricitinib

40.3

10.0

SAA03

NOMESCO Finland

Extended examination of mouth

1.4

9.9

546

4212

7151E

ICD-9 Finland

Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, LONKKANIVEL]

7.7

9.9

NBB10

NOMESCO Finland

Primary partial prosthetic replacement of humero-scapular joint not using cement, other or unspecified

8.2

9.8

NBB20

NOMESCO Finland

Primary total prosthetic replacement of humero-scapular joint

5.7

9.8

NGW10

NOMESCO Finland

Reoperation for deep infection in in surgery of knee or lower leg

26.2

9.8

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

1.4

9.8

491

3720

L04AC10

ATC

secukinumab; parenteral

8.8

9.8

M01AC01

ATC

piroxicam; systemic, rectal

1.7

9.7

221

1390

S01BA01

ATC

dexamethasone; ophthalmic (corticosteroids, plain)

2.6

9.7

260

J01CF02

ATC

cloxacillin; systemic

3.1

9.7

172

R05FA02

ATC

opium derivatives and expectorants; systemic

1.4

9.7

613

4849

NA7EA

NOMESCO Finland

Scoliosis X-ray examination

4.6

9.7

8441A

ICD-9 Finland

Sprains and strains of knee and leg, Medial collateral ligament of knee

7.4

9.7

C07AB07

ATC

bisoprolol; oral

1.4

9.7

749

6138

J02AC01

ATC

fluconazole; systemic

1.4

9.7

574

4487

-1

NOMESCO Finland

1.5

9.6

458

3435

WX200

NOMESCO Finland

Interscalenous plexus blockade

3.4

9.6

130

A01

ICPC

Pain general/multiple sites

2.0

9.6

121

624

M15.8

ICD-10 Finland

Other polyarthrosis

4.1

9.5

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

1.5

9.5

338

2380

ZZH21

NOMESCO Finland

Graft of patients own bone, small pieces

3.5

9.5

126

L86

ICPC

Back syndrome with radiating pain

2.3

9.5

397

NB2AT

NOMESCO Finland

Intra artrial injection of shoulder with ultrasound guidance

4.3

9.4

SPAT1262

SPAT

Handing over of treatment supplies

1.6

9.3

295

2019

M23

ICD-10 Finland

Internal derangement of knee

3.9

9.3

M06

ICD-10 Finland

Other rheumatoid arthritis

6.9

9.3

NGD25

NOMESCO Finland

Reinsertion of meniscus of knee, arthroscopic

6.9

9.3

SPAT1156

SPAT

Guidance concerning treatment of rash and skin

1.7

9.3

206

1286

R07.4

ICD-10 Finland

Chest pain, unspecified

1.5

9.3

418

3092

M45

ICD-10 Finland

Ankylosing spondylitis

3.4

9.3

128

M35.3

ICD-10 Finland

Polymyalgia rheumatica

2.5

9.3

274

M02AA15

ATC

diclofenac; topical (antiinflammatory prep., non-steroids for topical use)

1.9

9.2

127

679

WX203

NOMESCO Finland

Infraclavicular plexus blockade

3.0

9.2

173

RF220

NOMESCO Finland

4.4

9.2

G47.3

ICD-10 Finland

Sleep apnoea

1.5

9.2

324

2273

SPAT1212

SPAT

Extensive examination of musculoskeletal system

1.9

9.2

125

666

R03DC03

ATC

montelukast; oral

1.6

9.2

228

1467

M24.2

ICD-10 Finland

Disorder of ligament

5.2

9.1

7188E

ICD-9 Finland

Other derangement of joint, Other joint derangement, not elsewhere classified[MB ARTICULI, LIGAM ET CARTILAG AL DEF,LONKKANIVEL]

8.3

9.1

NGH20

NOMESCO Finland

Reduction of dislocation of knee joint, open

11.5

9.1

VALMI

NOMESCO Finland

1.5

9.1

329

2326

NHG82

NOMESCO Finland

Fusion of other tarsal joint

5.6

9.1

R52.2

ICD-10 Finland

Other chronic pain

2.8

9.0

209

82200

ICD-8 Finland

Fracture of patella, Closed

15.7

9.0

M20.4

ICD-10 Finland

Other hammer toe(s) (acquired)

2.5

9.0

295

M01AB08

ATC

etodolac; oral

2.0

9.0

117

612

M04AA01

ATC

allopurinol; systemic

1.7

9.0

198

1232

M21.4

ICD-10 Finland

Flat foot [pes planus] (acquired)

3.1

9.0

154

9056A

ICD-9 Finland

Late effects of musculoskeletal and connective tissue injuries, Late effect of dislocation

18.7

8.9

RF221

NOMESCO Finland

18.7

8.9

T84.9

ICD-10 Finland

Unspecified complication of internal orthopaedic prosthetic device, implant and graft

18.7

8.9

J01FA09

ATC

clarithromycin; systemic

1.4

8.9

460

3492

310

Kela drug reimbursment

Orlistat, sibutramine and other major and expensive medicines used to treat obesity

5.8

8.9

KMAK

NOMESCO Finland

1.4

8.9

745

6161

M79.1

ICD-10 Finland

Myalgia

1.7

8.9

174

1048

SFA30

NOMESCO Finland

Filling on tree or more surfaces of tooth

1.4

8.8

622

4994

NDF60

NOMESCO Finland

Operation for osteochondritis of a joint of hand,v

10.8

8.8

K57.3

ICD-10 Finland

Diverticular disease of large intestine without perforation or abscess

1.6

8.8

265

1795

M16

ICD-10 Finland

Coxarthrosis [arthrosis of hip]

2.4

8.7

315

SPAT1216

SPAT

Assessment of functional ability

1.6

8.7

223

1446

L34

ICPC

Musculoskeletal, Blood test

50.2

8.7

ABC56

NOMESCO Finland

Decompression of lumbar spinal canal and nerve roots

3.1

8.6

148

N05CF02

ATC

zolpidem; oral

1.6

8.6

254

1710

T84.4

ICD-10 Finland

Mechanical complication of other internal orthopaedic devices, implants and grafts

11.6

8.6

TNF11

NOMESCO Finland

Injection of diagnostic or therapeutic substance in hip joint

16.4

8.6

M08.0

ICD-10 Finland

Juvenile rheumatoid arthritis

10.1

8.5

Y83.9

ICD-10 Finland

Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

2.8

8.5

183

WX006

NOMESCO Finland

Intravenous sedation or analgesia without general anesthesia

7.4

8.4

S97

ICPC

Chronic ulcer skin

2.1

8.4

429

FB1BD

NOMESCO Finland

Extensive CT examination of arteria pulmonalis

1.9

8.4

122

665

NB1AD

NOMESCO Finland

Shoulder CT examination

4.1

8.4

NHG26

NOMESCO Finland

Fusion between bones of ankle or ankle and foot

5.1

8.3

7890A

ICD-9 Finland

Other symptoms involving abdomen and pelvis, Abdominal pain

2.1

8.3

411

R05

ICD-10 Finland

Cough

1.5

8.3

278

1926

NBA30

NOMESCO Finland

Exploration of joint of shoulder or upper arm, arthroscopic

2.7

8.3

197

ZZH31

NOMESCO Finland

Bone allograft, small pieces

5.8

8.3

C08CA01

ATC

amlodipine; oral

1.4

8.3

562

4470

S29

ICPC

Skin symptom/complaint other

1.6

8.3

241

1617

M67.0

ICD-10 Finland

Short Achilles tendon (acquired)

7.1

8.3

J01EE02

ATC

sulfadiazine and trimethoprim; systemic

1.5

8.2

366

2697

9284

FHL

Wrist ossification surgery

14.5

8.2

J01EA01

ATC

trimethoprim; systemic

1.5

8.1

360

2646

WYA05

NOMESCO Finland

Emergency visit or other similar visit involving procedures

1.4

8.1

700

5788

M54.9

ICD-10 Finland

Dorsalgia, unspecified

1.7

8.1

154

921

NF3AA

NOMESCO Finland

Femur X-ray examination

3.5

8.1

105

SPAT1306

SPAT

Counselling and guidance related to nutrition and weight management

1.6

8.1

191

1214

291

Kela drug reimbursment

Tofacitinib

17.2

8.1

FN1AC

NOMESCO Finland

Angiography of heart and/or coronary arteries

1.5

8.0

338

2458

M76.6

ICD-10 Finland

Achilles tendinitis

2.2

8.0

338

M66.0

ICD-10 Finland

Rupture of popliteal cyst

4.0

8.0

S70.0

ICD-10 Finland

Contusion of hip

2.6

7.9

215

L40.0

ICD-10 Finland

Psoriasis vulgaris

2.3

7.9

331

D48.0

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage

4.2

7.9

M07.0*L40.5

ICD-10 Finland

Distal interphalangeal psoriatic arthropathy

13.1

7.9

T81.0

ICD-10 Finland

Haemorrhage and haematoma complicating a procedure, not elsewhere classified

2.0

7.9

102

533

R01AD12

ATC

fluticasone furoate; nasal

1.4

7.9

387

2903

E882A

ICD-9 Finland

Fall from or out of building or other structure

5.4

7.8

J06.9

ICD-10 Finland

Acute upper respiratory infection, unspecified

1.4

7.8

538

4285

NHM20

NOMESCO Finland

Excision of synovial ganglion of ankle or foot

4.7

7.8

M19.8

ICD-10 Finland

Other specified arthrosis

2.6

7.8

228

M03BA52

ATC

carisoprodol, combinations excl. psycholeptics; oral

2.3

7.8

306

WX602

NOMESCO Finland

Repeated or continuing anesthesia shots throug a catheter

1.9

7.8

108

582

N05CF01

ATC

zopiclone; oral

1.4

7.8

494

3881

A02BB01

ATC

misoprostol; oral

7.0

7.8

NBL00

NOMESCO Finland

Suture or reinsertation of rotator cuff of shoulder

2.1

7.8

432

2402

FHL

External neurolysis of the nerve and possible alteration of the pathway (nerve pressure)

3.7

7.8

A06AC01

ATC

ispaghula (psylla seeds); oral

1.4

7.7

369

2752

K44.9

ICD-10 Finland

Diaphragmatic hernia without obstruction or gangrene

1.9

7.7

115

634

B01AA03

ATC

warfarin; systemic

1.5

7.7

293

2085

NK1XE

NOMESCO Finland

Other ultrasound examinnation of muscle or tendon

5.1

7.7

9473

FHL

Local soft tissue removal or exploration (eg Bursa)

6.4

7.7

SPAT1249

SPAT

Treatment-related counselling outside office

1.4

7.7

572

4607

D07AD01

ATC

clobetasol; topical

1.5

7.7

236

1600

J01DA06

ATC

[U] cefuroxime; systemic

1.6

7.6

221

1479

M11.2

ICD-10 Finland

Other chondrocalcinosis

11.9

7.6

9101

FHL

Bone biopsy

25.1

7.6

NFK30

NOMESCO Finland

Angulation, rotation or displacement osteotomy of femur

25.1

7.6

82121

ICD-8 Finland

Fracture of other and unspecified parts of femur, Lower end, closed

25.1

7.6

Z46.8

ICD-10 Finland

Fitting and adjustment of other specified devices

2.9

7.6

155

M50.1

ICD-10 Finland

Cervical disc disorder with radiculopathy

2.3

7.5

306

M20.1

ICD-10 Finland

Hallux valgus (acquired)

1.8

7.5

126

724

SPAT1312

SPAT

General health counselling

1.4

7.5

447

3471

A08AB01

ATC

orlistat; oral

7.1

7.5

NHL14

NOMESCO Finland

Shortening or lengthening of achilles tendon

7.1

7.5

T93.2

ICD-10 Finland

Sequelae of other fractures of lower limb

4.8

7.5

A02BX02

ATC

sucralfate; oral

2.2

7.4

309

M54.2

ICD-10 Finland

Cervicalgia

1.9

7.4

105

570

C01DA14

ATC

isosorbide mononitrate; oral

1.6

7.4

217

1455

71200

ICD-8 Finland

Rheumatoid arthritis and allied conditions, Juvenile rheumatoid arthritis

13.4

7.4

S01CA01

ATC

dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)

1.4

7.4

509

4046

R4180

NOMESCO Finland

Podiatric therapy

4.4

7.3

9522

FHL

Synovectomy

8.4

7.3

9245

FHL

Reconstruction or plastic surgery of ankle ligaments

8.4

7.3

R02

ICPC

Shortness of breath/dyspnoea

1.7

7.3

166

1044

I25.1

ICD-10 Finland

Atherosclerotic heart disease

1.4

7.3

321

2354

QCB10

NOMESCO Finland

Major dressing of wound of skin of upper limb

3.0

7.3

137

NGA20

NOMESCO Finland

Exploration of soft tissue knee or lower leg, open

10.9

7.3

9319

FHL

Other measure in this category

+∞

7.3

84490

ICD-8 Finland

+∞

7.3

L11

ICPC

Wrist symptom/complaint

1.9

7.3

106

582

L89

ICPC

Osteoarthrosis of hip

2.5

7.3

220

D82

ICPC

Teeth/gum disease

1.4

7.2

461

3615

L29

ICPC

Musculoskeletal sympt/complt other

1.9

7.2

103

560

SPAT1250

SPAT

Comprehensive monitoring of chronic illness

1.4

7.2

420

3243

NBG10

NOMESCO Finland

Acromioplastia

2.7

7.2

171

J45.8

ICD-10 Finland

Mixed asthma

2.6

7.2

196

L02.4

ICD-10 Finland

Cutaneous abscess, furuncle and carbuncle of limb

2.6

7.2

196

R2130

NOMESCO Finland

Counselling and guidance which enhance independent living

1.8

7.2

114

643

R01AD08

ATC

fluticasone; nasal

1.4

7.1

397

3038

NGE60

NOMESCO Finland

Plastic repair of patellar ligaments, open

20.1

7.1

J01XX08

ATC

linezolid; systemic

6.6

7.1

J15.9

ICD-10 Finland

Bacterial pneumonia, unspecified

1.8

7.1

124

720

M02.9

ICD-10 Finland

Reactive arthropathy, unspecified

3.6

7.1

205

Kela drug reimbursment

Chronic hypertension

1.4

7.1

429

3336

Z01.6

ICD-10 Finland

Radiological examination, not elsewhere classified

1.7

7.0

134

800

SPAT1310

SPAT

Counselling related to known health issue

1.4

7.0

456

3584

TNX32

NOMESCO Finland

Custom moulded splint, unspecified region

2.1

7.0

357

NA1BA

NOMESCO Finland

Cervical spine extensive X-ray examination without contrast

4.7

7.0

X57

ICD-10 Finland

Unspecified privation

3.0

7.0

124

OAB72

NOMESCO Finland

Weight control and weight loss guidance

7.0

9477

FHL

Cleansing or splitting of a tendon or tendon sheath (eg tenosynovectomy, tenolysis)

7.0

D07BA04

ATC

hydrocortisone and antiseptics; topical

1.7

7.0

127

751

K29.3

ICD-10 Finland

Chronic superficial gastritis

2.5

7.0

212

L99

ICPC

Musculoskeletal disease other

3.2

6.9

108

S83.7

ICD-10 Finland

Injury to multiple structures of knee

6.3

6.9

SDA02

NOMESCO Finland

Parodonthologic therapy

1.4

6.9

459

3619

H26.3

ICD-10 Finland

Drug-induced cataract

5.9

6.9

M01AE52

ATC

naproxen and esomeprazole; oral

2.4

6.9

233

E000001

ATC

1.5

6.9

279

2009

RF421

NOMESCO Finland

7.6

6.9

8449X

ICD-9 Finland

Sprains and strains of knee and leg, Unspecified site of knee and leg

7.6

6.9

NFC40

NOMESCO Finland

Repair of hip prosthesis by bone transplant to acetabulum

7.6

6.9

RT271

NOMESCO Finland

13.8

6.9

NHL68

NOMESCO Finland

Tenodesis, shortening or lengthening of tendon of foot

4.1

6.9

M43.1

ICD-10 Finland

Spondylolisthesis

2.2

6.9

294

P01AB01

ATC

metronidazole; oral, rectal

1.3

6.9

566

4616

K04.5

ICD-10 Finland

Chronic apical periodontitis

1.4

6.9

371

2825

WZC30

NOMESCO Finland

Teaching

1.5

6.9

211

1433

NAG40

NOMESCO Finland

Anterior fusion of cervical spine without fixation

2.9

6.9

142

EP1AE

NOMESCO Finland

Neck ultrasound examination

2.0

6.8

461

M03BC51

ATC

orphenadrine, combinations; systemic

1.4

6.8

400

3086

C09CA01

ATC

losartan; oral

1.4

6.8

363

2755

NA3EA

NOMESCO Finland

Lumbar spine X-ray examination with flexion

2.5

6.8

198

NE1CG

NOMESCO Finland

Pelvic, hip and femur extensive MRI examination with high intensity magnet

3.0

6.8

121

R53

ICD-10 Finland

Malaise and fatigue

1.5

6.8

271

1946

L04AA29

ATC

tofacitinib; oral

11.0

6.8

NFB50

NOMESCO Finland

Primary total prosthetic replacement of hip joint using cement

3.5

6.8

NGM20

NOMESCO Finland

Excision of synovial ganglion of knee or lower leg

9.3

6.8

N05CD07

ATC

temazepam; oral

1.6

6.8

197

1322

L01

ICPC

Neck symptom/complaint

1.6

6.8

185

1222

T93.3

ICD-10 Finland

Sequelae of dislocation, sprain and strain of lower limb

5.7

6.8

71005

ICD-8 Finland

Acute arthritis due to pyogenic organisms, Genus

40.2

6.8

9252

FHL

Plaster bandage placement or replacement (no fracture) in the operating room

16.8

6.7

NGF10

NOMESCO Finland

Total synovectomy of knee, open

16.8

6.7

N06AX16

ATC

venlafaxine; oral

1.6

6.7

183

1205

G55.2*M47.9

ICD-10 Finland

Nerve root and plexus compressions in spondylosis

3.4

6.7

QDB05

NOMESCO Finland

Revision of wound of skin of lower limb

2.8

6.7

151

F45.4

ICD-10 Finland

Persistent somatoform pain disorder

3.5

6.7

73105

ICD-8 Finland

Bursitis chronica, inflammation of the synovial membrane, bursa and tendon sheath

7.2

6.7

9527

FHL

Alloarthroplasty, implant or endoprosthesis

22.6

6.7

9964A

ICD-9 Finland

Complications peculiar to certain specified procedures, Mechanical complication of internal orthopaedic device, implant and graft

22.6

6.7

TPH30

NOMESCO Finland

Insertion of central venous catheter through periferal vein

3.3

6.7

S21

ICPC

Skin texture symptom/complaint

1.6

6.7

175

1144

N62

ICD-10 Finland

Hypertrophy of breast

2.3

6.6

244

R42

ICD-10 Finland

Dizziness and giddiness

1.4

6.6

303

2236

NA3CG

NOMESCO Finland

Lumbar spine extensive MRI examination with high intensity magnet

2.2

6.6

299

NDG76

NOMESCO Finland

Fusion of DIP joint

4.6

6.6

-56

ICPC

Dressing/pressure/compress/tamponade

3.1

6.6

107

K07.60

ICD-10 Finland

Snapping jaw

2.2

6.6

287

9058A

ICD-9 Finland

Late effects of musculoskeletal and connective tissue injuries, Late effect of tendon injury

12.3

6.6

R2110

NOMESCO Finland

Giving the first information

1.9

6.6

528

SPAT1254

SPAT

Administration of medicine

1.5

6.6

196

1322

N39.4

ICD-10 Finland

Other specified urinary incontinence

1.8

6.5

114

664

S72.3

ICD-10 Finland

Fracture of shaft of femur

4.8

6.5

XF400

NOMESCO Finland

ECG with 12 standard connections

1.5

6.5

234

1645

K05.10

ICD-10 Finland

Gingivitis (chronic) NOS

1.6

6.5

161

1037

Y0899

ICD-8 Finland

Investigation of musculoskeletal system

6.2

6.5

L50

ICPC

Musculoskeletal, Medication/prescr/renewal

6.2

6.5

SPAT1033

SPAT

Irrigation or wax removal of outer auditory canal

1.4

6.4

281

2052

T82

ICPC

Obesity

2.4

6.4

212

DM1QA

NOMESCO Finland

Paranasal sinuses X-ray examination in one projection

2.1

6.4

346

B01AF02

ATC

apixaban; oral

1.7

6.3

139

867

NFH30

NOMESCO Finland

Reduction of dislocation prosthesis of hip joint, closed

6.6

6.3

9503

FHL

Tendon or tendon sheath cleansing surgery (tenosynovectomy)

8.2

6.3

M65.3

ICD-10 Finland

Trigger finger

2.1

6.3

326

F32.9

ICD-10 Finland

Depressive episode, unspecified

1.6

6.3

145

916

H02AB08

ATC

triamcinolone; systemic

6.0

6.3

M35.0

ICD-10 Finland

Sicca syndrome [Sjögren]

2.9

6.3

125

NDB60

NOMESCO Finland

Prosthetic replacement of MCP joint of finger

11.1

6.3

NCB20

NOMESCO Finland

Primary total prosthetic replacement of elbow joint

11.1

6.3

Z47.9

ICD-10 Finland

Orthopaedic follow-up care, unspecified

11.1

6.3

NF1AT

NOMESCO Finland

Puncture of hip joint with ultrasound guidance

11.1

6.3

L04AD01

ATC

ciclosporin; systemic

2.7

6.3

146

M05BA07

ATC

risedronic acid; oral

2.3

6.3

239

H04.10

ICD-10 Finland

Dry eye syndrome

1.6

6.3

143

900

E83.30

ICD-10 Finland

Acid phosphatase deficiency

+∞

6.3

M362, D66

ICD-10 Finland

+∞

6.3

NGC40

NOMESCO Finland

Secondary implantation of prosthesis in knee joint with allograft bone transplant

+∞

6.3

72903

ICD-8 Finland

Other diseases of joint, Hydrarthrosis

+∞

6.3

B02BD02

ATC

coagulation factor VIII; parenteral, topical, urethral

+∞

6.3

R03AK06

ATC

salmeterol and fluticasone; inhalant

1.5

6.2

194

1320

J01FA15

ATC

telithromycin; oral

1.6

6.2

143

903

M76.9

ICD-10 Finland

Enthesopathy of lower limb, unspecified

4.1

6.2

P06

ICPC

Sleep disturbance

1.7

6.2

126

768

A07AA02

ATC

nystatin; oral

1.8

6.2

518

T78.3

ICD-10 Finland

Angioneurotic oedema

3.7

6.2

S46.1

ICD-10 Finland

Injury of muscle and tendon of long head of biceps

3.8

6.2

Y89.9

ICD-10 Finland

Sequelae of unspecified external cause

4.5

6.2

E8879

ICD-8 Finland

Other and unspecified fall

5.4

6.2

D50.9

ICD-10 Finland

Iron deficiency anaemia, unspecified

1.8

6.1

107

624

C01CA24

ATC

epinephrine; parenteral

1.9

6.1

431

M54.3

ICD-10 Finland

Sciatica

1.9

6.1

446

TND10

NOMESCO Finland

Joint puncture, wrist or finger joint

7.7

6.1

D01AC20

ATC

imidazoles/triazoles in combination with corticosteroids; topical

1.4

6.1

328

2492

203

Kela drug reimbursment

Chronic asthma and similar chronic obstructive pulmonary diseases

1.4

6.1

269

1972

A08AA02

ATC

fenfluramine; oral (centrally acting antiobesity products)

4.7

6.1

72901

ICD-8 Finland

Other diseases of joint, Corpus liberum articuli

12.6

6.1

NAG62

NOMESCO Finland

Posterior fusion of lumbar spine with fixation, 2-3 vertebraea

2.9

6.1

114

J32.0

ICD-10 Finland

Chronic maxillary sinusitis

1.8

6.1

106

617

G04BD12

ATC

mirabegron; oral

1.6

6.1

141

894

290

Kela drug reimbursment

Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation

1.5

6.0

206

1433

8363A

ICD-9 Finland

Dislocation of knee, Dislocation of patella, simple

6.7

6.0

M47.80

ICD-10 Finland

Other spondylosis, multiple sites in spine

2.5

6.0

190

M24.5

ICD-10 Finland

Contracture of joint

10.1

6.0

NDB78

NOMESCO Finland

Prosthetic replacement of several of finger or metacarpal

10.1

6.0

S19

ICPC

Skin injury other

2.3

6.0

239

82300

ICD-8 Finland

Fracture of tibia and fibula, Upper end or unspecified part, closed

5.2

6.0

SPAT1305

SPAT

Counselling and guidance related to physical exercise

1.7

6.0

126

776

NAME	SCND_OTH_KNEEARTHROSIS
CONTROL_EXCLUDE	KNEE_ARTHROSIS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M175
HD_ICD_9	7152F
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M175
COD_ICD_9	7152F
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Parameter	HR [95% CI]	p-value
SCND_OTH_KNEEARTHROSIS	1.12 [1.01, 1.25]	0.038
Birth year	0.998 [0.99, 1.01]	0.606

Parameter	HR [95% CI]	p-value
SCND_OTH_KNEEARTHROSIS	0.972 [0.87, 1.09]	0.621
Birth year	0.987 [0.98, 1.0]	0.007

N-year risk	Females	Males
1	0.11%	0.173%
5	0.715%	1.05%
10	1.69%	2.695%
15	3.183%	5.245%
20	6.244%	9.207%

Other secondary gonarthrosis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints