Infectious mononucleosis

AB1_EBV

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 B27
  • Hospital discharge: ICD-10 B27
  • Hospital discharge: ICD-9 07[5]
  • Hospital discharge: ICD-8 07[5]
  • Cause of death: ICD-10 B27
  • Cause of death: ICD-9 07[5]
  • Cause of death: ICD-8 07[5]

3 out of 7 registries used, show all original rules.

3952

4. Check minimum number of events

None

3952

5. Include endpoints

None

3952

6. Filter based on genotype QC (FinnGen only)

3952

Control definitions (FinnGen only)

Control exclude
AB1_OTHER_VIRAL

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF10

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 47049 23385 23582
Only index persons 45510 22770 22740
Unadjusted period prevalence (%)
Whole population 0.66 0.67 0.66
Only index persons 0.85 0.84 0.87
Median age at first event (years)
Whole population 17.86 17.23 18.46
Only index persons 17.91 17.29 18.54

-FinnGen-

Key figures

All Female Male
Number of individuals 3952 2551 1401
Unadjusted period prevalence (%) 0.78 0.87 0.62
Median age at first event (years) 18.57 17.92 19.76

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
3546
Matched controls
35458
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
B27.9
ICD-10 Finland
Infectious mononucleosis, unspecified
+∞
323.0
842
*
0750X
ICD-9 Finland
Infectious mononucleosis[MONONUCLEOSIS INFECTIOSA SINE COMPLICATIONE]
+∞
323.0
334
*
07501
ICD-8 Finland
Infectious mononucleosis, Angina monocytotica
+∞
323.0
391
*
B27.0
ICD-10 Finland
Gammaherpesviral mononucleosis
+∞
323.0
1415
*
B27
ICD-10 Finland
Infectious mononucleosis
+∞
291.7
276
*
07509
ICD-8 Finland
Infectious mononucleosis, Unspecified
+∞
157.5
150
*
0750A
ICD-9 Finland
Infectious mononucleosis[MONONUCLEOSIS INFECTIOSA CUM COMPLICATIONE]
+∞
145.8
139
*
J03.9
ICD-10 Finland
Acute tonsillitis, unspecified
3.3
98.9
569
1948
07507
ICD-8 Finland
Infectious mononucleosis, Cum alia complicatione
+∞
90.0
86
*
07508
ICD-8 Finland
Infectious mononucleosis, Suspecta
+∞
81.6
78
*
B27.8
ICD-10 Finland
Other infectious mononucleosis
+∞
76.3
73
*
R50.9
ICD-10 Finland
Fever, unspecified
2.5
61.8
570
2562
B27.1
ICD-10 Finland
Cytomegaloviral mononucleosis
+∞
59.5
57
*
B34.9
ICD-10 Finland
Viral infection, unspecified
6.7
57.3
152
237
J36
ICD-10 Finland
Peritonsillar abscess
3.1
40.8
237
796
J02.9
ICD-10 Finland
Acute pharyngitis, unspecified
2.4
40.7
362
1576
EMB10
NOMESCO Finland
Tonsillectomy
2.2
39.9
428
2041
M01AE03
ATC
ketoprofen; systemic, rectal
1.7
35.5
877
5688
J03.0
ICD-10 Finland
Streptococcal tonsillitis
2.5
31.0
251
1035
J35.0
ICD-10 Finland
Chronic tonsillitis
2.1
26.8
335
1698
A75
ICPC
Infectious mononucleosis
26.4
24.8
34
13
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
24.8
1911
15850
R21
ICPC
Throat symptom/complaint
1.5
24.3
1091
8094
J01DB01
ATC
cefalexin; oral
1.5
23.2
2746
24638
J01FA10
ATC
azithromycin; systemic
1.4
22.3
2209
19022
H02AB06
ATC
prednisolone; systemic
1.5
21.7
1173
8991
N02BE01
ATC
paracetamol; systemic, rectal
1.4
21.3
2564
22798
R03AC02
ATC
salbutamol; inhalant
1.4
21.3
1662
13646
N02AX02
ATC
tramadol; systemic, rectal
1.5
21.1
897
6536
J01AA02
ATC
doxycycline; systemic
1.4
20.6
2045
17484
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
20.6
1183
9157
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
20.2
381
2238
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
20.0
870
6356
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.5
19.0
792
5722
J01FF01
ATC
clindamycin; systemic
1.5
18.0
706
5026
J01FA06
ATC
roxithromycin; oral
1.4
16.9
1009
7798
A03
ICPC
Fever
1.5
16.3
747
5485
A02BC02
ATC
pantoprazole; systemic
1.3
16.0
1512
12602
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.9
15.7
220
1167
R06AE07
ATC
cetirizine; oral
1.3
15.7
1478
12299
07997
ICD-8 Finland
Other viral diseases, Viroses suspectae
+∞
15.6
15
*
J01DA01
ATC
[U] cefalexin; systemic
1.3
15.6
1843
15870
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
15.3
413
2683
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.5
15.0
589
4177
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
14.8
1164
9386
M01AE01
ATC
ibuprofen; systemic, rectal
1.5
14.8
3057
28685
J01CE02
ATC
phenoxymethylpenicillin; oral
1.3
13.8
2511
22838
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.4
13.6
787
6005
R01AD12
ATC
fluticasone furoate; nasal
1.4
13.6
1058
8488
J01FA09
ATC
clarithromycin; systemic
1.4
13.6
940
7398
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
13.6
1057
8480
J02
ICD-10 Finland
Acute pharyngitis
2.1
13.0
151
744
R07.0
ICD-10 Finland
Pain in throat
1.7
12.9
250
1478
P01AB01
ATC
metronidazole; oral, rectal
1.3
12.8
1015
8149
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.5
12.5
432
2972
R51.80
ICD-10 Finland
Headache
1.5
12.5
524
3759
J01MA02
ATC
ciprofloxacin; systemic
1.4
12.4
801
6221
J03
ICD-10 Finland
Acute tonsillitis
2.0
12.2
153
779
R01AD09
ATC
mometasone; nasal
1.3
11.8
1422
12089
R01AD08
ATC
fluticasone; nasal
1.4
11.7
831
6543
J01FA01
ATC
erythromycin; systemic
1.4
11.5
520
3782
B25.8
ICD-10 Finland
Other cytomegaloviral diseases
+∞
11.5
11
*
07999
ICD-8 Finland
Other viral diseases, Viral infection, unspecified
+∞
11.5
11
*
M03BX02
ATC
tizanidine; oral
1.3
11.2
1695
14813
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
1.4
10.9
718
5572
J01MA12
ATC
levofloxacin; systemic
1.6
10.9
324
2151
07502
ICD-8 Finland
Infectious mononucleosis, cum meningoencephalitidie
+∞
10.4
10
*
R03BA05
ATC
fluticasone; inhalant
1.4
10.3
522
3871
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.5
10.1
412
2937
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
3.7
10.1
42
114
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
4.5
10.0
34
76
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.5
10.0
300
2001
E0000UV
ATC
NA
1.3
9.9
1210
10245
4452
FHL
Tonsil surgery
2.1
9.8
109
531
J01FA15
ATC
telithromycin; oral
1.6
9.7
228
1429
M01AE02
ATC
naproxen; oral, rectal
1.2
9.5
1826
16287
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.8
9.5
152
845
M01AB05
ATC
diclofenac; systemic, rectal
1.2
9.4
1703
15080
B25.9
ICD-10 Finland
Cytomegaloviral disease, unspecified
100.3
9.4
10
*
H02AB04
ATC
methylprednisolone; systemic
1.6
9.4
271
1787
S01GX01
ATC
cromoglicic acid; ophthalmic
1.3
9.3
651
5091
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
1.5
9.3
295
1989
J02AC01
ATC
fluconazole; systemic
1.3
8.9
1091
9212
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.4
8.8
420
3080
K76.9
ICD-10 Finland
Liver disease, unspecified
3.5
8.7
39
113
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.2
8.6
88
413
R05
ICPC
Cough
1.3
8.6
652
5161
A02BC01
ATC
omeprazole; systemic
1.4
8.5
528
4052
SPAT1263
SPAT
Sampling
1.2
8.2
1319
11467
M01AH05
ATC
etoricoxib; oral
1.2
8.2
1458
12815
R05FA02
ATC
opium derivatives and expectorants; systemic
1.3
8.1
989
8323
127
Kela drug reimbursment
Transplant complication
3.2
8.1
41
131
R03DC03
ATC
montelukast; oral
1.4
8.1
432
3231
B99
ICD-10 Finland
Other and unspecified infectious diseases
3.0
8.0
44
150
SPAT1283
SPAT
Restricted health certificate
1.3
7.9
924
7731
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
1.9
7.9
113
609
J45.9
ICD-10 Finland
Asthma, unspecified
1.4
7.8
403
2997
B19.9
ICD-10 Finland
Unspecified viral hepatitis without hepatic coma
8.5
7.8
16
19
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.2
7.8
1686
15103
C01CA24
ATC
epinephrine; parenteral
1.6
7.7
215
1407
J02.0
ICD-10 Finland
Streptococcal pharyngitis
1.9
7.7
102
534
R74
ICPC
Upper respiratory infection acute
1.2
7.7
1203
10404
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.4
7.6
442
3355
N03AX16
ATC
pregabalin; oral
1.4
7.5
423
3192
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.5
7.4
271
1891
R02AD02
ATC
lidocaine; local oral
2.3
7.4
65
289
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
1.7
7.3
150
905
AA1AD
NOMESCO Finland
CT of head and brain
1.4
7.3
351
2576
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.2
7.3
1005
8558
0785A
ICD-9 Finland
Other diseases due to viruses and Chlamydiae, Cytomegaloviral disease[MONONUCLEOSIS INFECTIOSA CYTOMEGALICA]
+∞
7.3
7
*
B17.8
ICD-10 Finland
Other specified acute viral hepatitis
30.1
7.1
9
*
N05BA04
ATC
oxazepam; oral
1.3
7.1
590
4716
R06AE09
ATC
levocetirizine; oral
1.3
7.1
465
3594
L04.0
ICD-10 Finland
Acute lymphadenitis of face, head and neck
2.6
6.9
46
178
W19
ICD-10 Finland
Unspecified fall
1.5
6.8
211
1416
Z01.8
ICD-10 Finland
Other specified special examinations
1.3
6.8
474
3693
0340A
ICD-9 Finland
Streptococcal sore throat and scarlatina, Streptococcal sore throat[TONSILLITIS STREPTOCOCCICA,STREPTOC BETAHAEMOLYT-A]
4.4
6.8
23
53
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
1.5
6.7
193
1274
J01CA04
ATC
amoxicillin; systemic
1.3
6.7
2898
27650
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.3
6.6
727
6022
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.3
6.5
439
3409
S06.0
ICD-10 Finland
Concussion
1.4
6.5
303
2213
UJF32
NOMESCO Finland
Coloscopy
1.3
6.4
397
3039
ZX120
NOMESCO Finland
Intravenous
1.6
6.2
168
1098
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
1.4
6.2
252
1796
R03BA02
ATC
budesonide; inhalant
1.3
6.2
441
3451
R06AX26
ATC
fexofenadine; oral
1.5
6.2
184
1228
A02BC05
ATC
esomeprazole; systemic
1.2
6.1
800
6752
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
2.4
6.1
47
195
R03AK07
ATC
formoterol and budesonide; inhalant
1.3
6.1
461
3637
R05
ICD-10 Finland
Cough
1.3
6.1
426
3321
03400
ICD-8 Finland
Streptococcal sore throat and scarlet fever, Streptococcal sore throat
3.9
6.1
23
60
M79.6
ICD-10 Finland
Pain in limb
1.2
6.0
832
7062
E000001
ATC
NA
1.3
6.0
628
5165

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
718
2030
4.10
224.85
1.4
1.3
—
—
—
0
0
282
950
3.12
64.39
1.3
1.3
188.2
232.7
u/ml
1.85
176
585
36
10
36.32
57.39
1.1
1.2
—
—
—
0
0
1925
14958
1.56
39.86
6.1
5.8
31.9
30.2
%
8.12
1805
14132
1838
14183
1.55
38.93
6.3
6.1
8.0
8.1
%
0.39
1729
13425
1816
14085
1.54
36.87
6.2
5.9
2.6
2.8
%
2.80
1698
13233
1885
14759
1.53
36.49
5.8
5.7
54.1
55.9
%
8.37
1775
13983
1750
13562
1.52
35.05
6.2
6.0
0.7
0.7
%
0.13
1636
12753
1633
12544
1.51
33.67
6.1
5.2
11.3
10.4
umol/l
1.91
1517
11766
2111
17121
1.50
33.32
8.2
8.4
3.9
4.0
e9/l
1.12
1869
15038
1965
15742
1.49
32.69
6.0
5.8
2.2
2.0
e9/l
2.83
1787
14165
813
5361
1.65
32.49
3.9
3.8
—
—
—
0
0
2417
20253
1.50
31.80
7.4
6.3
76.2
73.0
u/l
3.13
2300
19104
1934
15553
1.48
30.88
6.3
6.2
0.2
0.2
e9/l
2.02
1747
13921
1870
14993
1.47
29.99
6.1
5.9
0.6
0.5
e9/l
1.97
1671
13216
1872
15026
1.47
29.76
6.1
5.9
0.0
0.0
e9/l
1.52
1667
13227
200
851
2.42
28.84
1.2
1.4
—
—
—
0
0
200
854
2.41
28.62
1.2
1.4
31.1
23.2
u/ml
—
10
16
3500
32240
1.75
27.06
11.9
9.4
20.5
20.2
mg/l
0.21
2864
24246
1260
9504
1.48
26.75
6.3
6.0
—
—
—
0
0
187
804
2.39
26.35
1.3
1.4
117.5
110.2
u/ml
0.08
29
153
1092
8050
1.49
25.81
2.5
2.4
53.6
55.5
u/l
1.18
1018
7488
1058
7817
1.48
24.49
4.2
4.0
—
—
—
0
0
2457
21255
1.41
23.17
3.8
3.5
8.5
8.3
mm/h
0.60
2319
19928
388
2300
1.76
22.45
2.7
2.5
10.9
10.5
g/l
1.30
356
2109
922
6749
1.48
21.99
1.6
1.5
—
—
—
0
0
1659
13637
1.37
20.10
9.0
7.9
0.0
0.0
e9/l
0.36
1369
11230
356
2125
1.74
20.04
4.5
4.4
0.6
0.8
%
0.80
112
494
342
2039
1.74
19.32
4.5
4.5
0.1
0.1
%
0.29
107
453
3518
32959
1.61
19.22
11.4
9.6
70.7
70.4
umol/l
0.31
3518
32944
3235
29839
1.46
18.28
10.6
9.2
3.9
3.9
mmol/l
0.48
3148
28801
714
5136
1.48
18.18
2.6
2.3
7.4
8.2
e6/l
0.56
631
4485
299
1746
1.77
18.14
1.8
1.7
1.5
1.2
g/l
1.25
274
1627
3226
29754
1.46
18.11
10.5
9.1
139.4
139.5
mmol/l
3.96
3150
28803
327
1960
1.73
18.11
4.4
4.2
0.4
0.6
%
0.68
87
374
78
266
2.97
17.50
1.3
1.1
—
—
—
0
0
2601
23188
1.36
17.46
3.1
2.8
39.2
36.1
u/l
1.80
2501
22257
988
7598
1.40
17.37
3.0
2.7
75.0
108.1
e6/l
0.30
763
5606
3545
33442
1.58
16.82
9.2
7.7
31.2
27.1
u/l
8.30
3469
32464
919
7030
1.40
16.55
2.8
2.6
—
—
—
0
0
662
4786
1.46
16.26
2.7
2.4
576.3
561.3
mosm/kgh2o
0.76
570
4092
2263
19883
1.32
16.05
4.2
3.6
1219.8
992.1
e6/l
0.08
33
206
2376
21105
1.32
15.13
4.1
3.6
—
—
—
0
0
314
1959
1.65
14.94
4.6
4.5
0.0
0.3
%
0.69
95
392
1191
9661
1.33
14.42
3.5
3.1
26.1
67.9
e6/l
5.59
831
6163
75
280
2.71
14.30
3.9
2.9
1.3
1.3
%
0.02
62
230
1142
9244
1.33
13.93
3.0
2.5
—
—
—
0
0
993
7877
1.35
13.89
5.2
5.1
1.1
1.1
inr
0.30
398
2719
888
6926
1.36
13.85
2.9
2.6
0.3
0.3
e6/l
0.29
655
5031
3606
34416
1.55
13.21
10.5
8.6
—
—
—
0
0
1177
9635
1.32
13.10
5.1
4.6
37.1
37.3
g/l
0.68
1100
8996
1771
15301
1.29
13.08
4.5
4.1
0.0
0.0
estimate
0.50
435
3165
1778
15399
1.28
12.77
3.4
3.0
0.0
0.0
estimate
0.27
424
3067
1766
15299
1.28
12.59
3.3
2.9
0.0
0.0
estimate
1.08
421
3046
598
4439
1.41
12.46
1.4
1.4
389.0
554.8
titre
2.45
109
800
982
7936
1.32
11.76
1.5
1.4
2.1
2.1
g/l
0.08
668
5100
58
211
2.77
11.69
5.3
3.6
—
—
—
0
0
3434
32599
1.41
11.56
11.0
10.0
40.7
40.7
%
0.18
2932
27460
1001
8148
1.31
11.31
3.5
3.1
0.0
0.0
estimate
0.16
407
3087
315
2104
1.54
11.24
1.2
1.2
—
—
—
0
0
1205
10057
1.29
11.22
3.6
3.0
34.7
30.2
u/l
2.33
1159
9585
949
7682
1.31
11.14
2.6
2.5
18.3
65.5
ng/l
0.80
406
3309
456
3298
1.43
10.93
1.6
1.6
—
—
—
0
0
411
2928
1.45
10.68
3.5
2.8
9.7
6.5
umol/l
1.91
351
2486
871
7011
1.31
10.58
6.4
6.6
—
—
—
0
0
3823
37214
1.84
10.58
16.6
13.9
257.6
261.2
e9/l
3.11
3769
36384
776
6150
1.33
10.53
2.0
2.1
175.6
231.9
u/l
0.99
735
5839
1151
9629
1.28
10.35
5.6
5.3
1.2
1.2
mmol/l
1.63
1058
8832
3825
37265
1.82
10.18
16.5
13.8
89.2
89.3
fl
0.76
3800
36858
3825
37265
1.82
10.18
16.5
13.8
29.9
29.9
pg
0.09
3800
36858
3047
28547
1.29
10.17
12.9
11.5
13.3
13.3
%
0.08
2999
27968
3827
37294
1.83
10.12
16.6
13.9
6.8
6.8
e9/l
0.73
3768
36393
3825
37275
1.81
10.02
16.6
13.8
4.6
4.6
e12/l
0.02
3768
36400
405
2914
1.43
9.97
3.8
3.1
—
—
—
0
0
3826
37297
1.81
9.88
16.7
13.9
137.3
137.4
g/l
0.14
3801
36887
809
6517
1.30
9.67
2.1
1.9
0.9
0.9
mg/l
0.12
548
4589
148
852
1.77
9.52
1.2
1.4
88.6
88.5
titre
0.00
21
93
166
989
1.71
9.46
1.8
1.6
5.2
9.0
u/ml
0.80
11
41
101
517
1.98
9.38
3.2
3.0
2.0
2.1
mmol/l
0.05
67
294
1268
10830
1.25
9.37
6.3
5.8
1.2
1.2
mmol/l
0.63
1066
9206
732
5863
1.31
9.07
2.4
2.2
2260.8
3159.4
umol/l
0.39
660
5314
111
594
1.89
9.06
1.2
1.2
—
—
—
0
0
293
2019
1.49
9.03
2.7
2.5
0.2
0.2
g/l
0.05
273
1879
76
355
2.16
9.02
1.3
1.4
—
—
—
0
0
111
595
1.89
9.01
3.3
3.0
7.4
7.4
ph
1.45
100
509
309
2159
1.47
8.88
2.4
2.3
20.6
20.8
au/ml
0.01
31
177
898
7406
1.28
8.84
2.4
2.2
—
—
—
0
0
173
1074
1.64
8.47
2.6
2.4
0.3
0.2
e6/l
1.04
166
1030
791
6454
1.28
8.45
1.7
1.7
—
—
—
0
0
654
5208
1.31
8.41
3.1
2.6
111.7
109.8
ug/g
0.06
540
4115
289
2024
1.46
8.22
1.3
1.3
42.7
37.9
au/ml
0.14
13
77
785
6423
1.28
8.17
4.1
3.7
95.6
95.4
%
0.09
757
6241
111
617
1.82
8.08
1.1
1.1
—
—
—
0
0
108
598
1.83
7.97
1.1
1.1
—
—
—
0
0
1715
15318
1.21
7.86
4.6
4.1
6.2
6.3
mmol/l
0.34
1575
13653
208
1375
1.54
7.83
1.7
1.7
—
—
—
0
0
200
1313
1.55
7.77
3.0
2.9
79.2
71.9
e9/l
1.06
147
955
108
606
1.80
7.65
3.8
3.8
55.0
55.9
%
0.27
108
606
3064
29018
1.25
7.61
4.6
4.3
1.7
2.0
mu/l
1.65
2920
27517
1564
13884
1.21
7.54
2.3
2.1
—
—
—
0
0
614
4920
1.29
7.49
1.3
1.3
6.7
9.0
u/ml
0.67
265
2050
1313
11508
1.21
7.12
2.4
2.2
72.5
70.4
nmol/l
2.04
1236
10796
1244
10856
1.21
7.04
1.9
1.8
—
—
—
0
0
1357
11943
1.21
7.02
3.0
2.8
—
5.8
—
0
8
41
164
2.52
6.99
3.1
3.1
0.1
0.2
e9/l
1.67
41
158
755
6265
1.25
6.87
3.8
3.6
7.4
7.4
ph
0.16
171
1213
60
287
2.11
6.80
2.1
2.5
43.4
44.2
%
—
8
39
642
5240
1.27
6.72
1.3
1.3
19.8
23.8
iu/ml
0.80
184
1479
1073
9268
1.22
6.67
1.4
1.3
1.6
1.7
u/ml
0.12
327
2540
273
1971
1.41
6.62
3.6
2.9
1.8
1.7
%
1.03
250
1770
432
3364
1.32
6.48
1.9
1.9
—
—
—
0
0
102
595
1.73
6.39
3.7
3.6
4.1
3.9
e9/l
0.25
102
595
2672
25112
1.20
6.38
4.0
3.8
14.4
14.4
pmol/l
0.25
2500
23211
346
2618
1.35
6.32
2.8
3.1
—
—
—
0
0
1907
17433
1.18
6.20
2.9
2.6
—
—
—
0
0
61
307
2.00
6.07
2.8
2.7
1.2
1.2
e9/l
0.11
36
164
175
1181
1.50
6.05
2.9
2.1
68.0
68.0
g/l
0.00
170
1112
188
1290
1.48
6.00
3.5
3.1
5.1
5.1
kpa
0.00
174
1216
481
3840
1.29
5.99
2.4
2.5
5.6
3.7
e6/l
1.46
248
1940
661
5487
1.25
5.94
2.6
2.6
—
—
—
0
0
358
2749
1.33
5.93
1.4
1.4
—
—
—
0
0
78
431
1.83
5.89
2.7
2.1
17.7
17.5
%
0.10
33
208
506
4077
1.28
5.86
2.6
2.4
7753.1
6660.5
u/l
0.28
187
1642
139
899
1.57
5.85
1.2
1.1
—
—
—
0
0
139
900
1.56
5.82
1.2
1.1
—
—
—
0
0
29
108
2.70
5.75
1.2
1.1
—
—
—
0
0
29
108
2.70
5.75
1.2
1.1
—
—
—
0
0
29
108
2.70
5.75
1.2
1.1
—
—
—
0
0
144
944
1.55
5.72
1.3
1.3
—
—
—
0
0
876
7518
1.21
5.69
2.9
2.8
2.3
2.3
mmol/l
0.17
798
6836
185
1281
1.47
5.66
3.5
3.1
7.4
7.4
ph
0.00
29
156
88
512
1.74
5.61
3.9
2.7
—
—
—
0
0
226
1642
1.40
5.33
3.3
3.1
1.2
1.2
mmol/l
2.32
194
1422
172
1192
1.46
5.26
2.4
2.4
20.9
21.0
s
0.04
144
1004
1810
16614
1.17
5.26
3.0
2.8
90.2
75.2
ug/l
2.07
1711
15744
55
282
1.96
5.25
1.1
1.2
—
—
—
0
0
152
1033
1.49
5.14
1.2
1.1
—
—
—
0
0
409
3264
1.28
5.12
2.6
2.4
29.7
29.4
s
0.34
392
3158
51
259
1.98
5.02
1.1
1.1
—
—
—
0
0
286
2187
1.33
4.91
2.9
3.4
4.7
4.7
pmol/l
0.07
255
1975
279
2127
1.34
4.89
1.1
1.1
424.3
190.8
titre
—
7
56
26
100
2.61
4.88
2.2
2.2
—
—
—
0
0
15
42
3.58
4.76
1.0
1.2
—
—
—
0
0
142
969
1.48
4.73
1.2
1.1
—
—
—
0
0
314
2449
1.31
4.69
2.3
2.4
35.5
56.7
u/l
0.55
269
2110
462
3786
1.25
4.63
2.8
2.8
589.3
500.1
ng/l
0.09
216
2002
1217
10914
1.17
4.63
1.8
1.8
—
—
—
0
0
280
2155
1.32
4.61
1.4
1.4
—
—
—
0
0
146
1009
1.46
4.58
1.8
1.9
1.2
1.2
g/l
0.56
141
963
396
3198
1.26
4.51
1.6
1.6
1125.1
1140.6
nmol/l
0.15
324
2492
35
161
2.18
4.49
2.6
2.3
7.9
9.8
mg/l
1.16
29
136
47
242
1.95
4.48
2.1
2.2
11.2
12.1
%
0.20
22
140
38
181
2.11
4.47
1.2
1.1
—
—
—
0
0
34
155
2.20
4.46
1.2
1.1
—
—
—
0
0
26
105
2.49
4.45
2.2
2.1
8.1
8.5
%
0.08
26
100
319
2512
1.29
4.45
1.4
1.3
199.9
263.2
u/ml
1.05
290
2327
48
250
1.93
4.43
1.1
1.1
—
—
—
0
0
27
112
2.42
4.38
2.3
2.1
—
—
—
0
0
367
2954
1.27
4.30
2.5
2.3
24.4
24.5
%
0.06
329
2573
486
4043
1.23
4.25
2.4
2.4
0.8
1.1
e6/l
1.29
254
2145
35
165
2.13
4.24
5.6
3.1
56.8
55.2
%
0.16
24
116
440
3623
1.24
4.23
2.4
2.2
15.3
14.9
umol/l
0.38
414
3371
113
754
1.51
4.23
1.6
1.6
1077.9
5784.0
e6/l
0.48
93
611
113
754
1.51
4.23
1.6
1.6
32.2
17.5
e6/l
0.56
92
582
47
248
1.91
4.20
2.1
2.2
73.2
75.0
%
0.35
47
238
35
166
2.12
4.18
1.3
1.4
—
—
—
0
0
266
2064
1.31
4.16
1.7
2.2
4.3
4.2
e9/l
0.10
223
1739
417
3422
1.24
4.14
4.5
3.8
0.8
0.8
mmol/l
0.22
389
3230
2879
27600
1.16
4.06
3.2
3.1
5.6
5.6
mmol/l
0.42
2718
25915
38
189
2.02
4.02
1.1
1.1
—
—
—
0
0
103
682
1.52
4.02
1.2
1.1
12.6
11.8
au/ml
—
8
55
127
878
1.46
4.02
2.4
1.8
—
—
—
0
0
67
401
1.68
3.97
1.0
1.1
1.5
1.4
g/l
0.23
61
364
124
856
1.46
3.96
1.4
1.5
432.3
448.5
mg/l
0.14
116
810
362
2947
1.25
3.87
2.1
2.0
366.7
385.1
nmol/l
1.11
331
2710
398
3275
1.24
3.87
2.3
2.2
2.5
2.5
g/l
0.73
365
3043
85
546
1.57
3.81
2.1
2.1
1.6
1.7
ug/l
0.04
78
494
74
460
1.62
3.80
3.0
2.4
24.2
24.1
mmol/l
0.12
66
419
234
1808
1.31
3.79
4.7
4.4
1.4
1.8
mmol/l
1.07
193
1443
21
83
2.54
3.79
1.4
1.7
—
—
—
0
0
1067
9599
1.15
3.76
1.8
1.8
—
—
—
0
0
23
96
2.40
3.72
7.9
8.6
95.2
73.8
mg/l
0.59
18
72
235
1825
1.31
3.68
4.4
4.3
5.9
5.9
kpa
0.03
228
1770
54
313
1.74
3.62
1.3
1.3
—
—
—
0
0
104
708
1.48
3.59
1.5
1.6
—
—
—
0
0
970
8695
1.15
3.57
1.7
1.6
97.1
98.0
pmol/l
0.28
581
4880
174
1304
1.35
3.50
1.2
1.3
0.2
0.8
u/ml
—
8
97
13
41
3.18
3.49
3.2
3.3
—
—
—
0
0
109
755
1.46
3.46
1.4
1.4
3.4
3.6
mmol/l
1.37
99
704
129
924
1.41
3.42
3.7
3.3
—
—
—
0
0
153
1128
1.37
3.42
5.6
4.9
24.3
24.1
mmol/l
0.37
138
1032
209
1615
1.31
3.42
2.5
3.0
—
—
—
0
0
218
1701
1.30
3.33
8.0
8.6
—
—
—
0
0
45
255
1.77
3.29
3.1
2.8
554.7
775.4
e6/l
1.78
21
98
118
840
1.42
3.26
3.2
3.2
1.3
1.4
%
0.50
118
834
20
84
2.39
3.22
1.3
1.3
—
—
—
0
0
286
2318
1.25
3.22
7.5
7.1
104.7
104.8
mmol/l
0.24
281
2266
404
3396
1.21
3.22
2.3
2.5
2.4
2.4
mmol/l
0.01
360
2975
326
2688
1.23
3.14
2.2
2.3
0.6
0.6
ug/l
0.11
155
1344
376
3147
1.22
3.13
1.2
1.2
—
—
—
0
0
533
4611
1.18
3.09
3.3
3.1
2.3
1.6
ug/l
0.94
492
4246
801
7151
1.15
3.09
3.4
3.3
9.1
8.8
mmol/l
0.80
690
6299
45
261
1.73
3.06
1.2
1.3
—
—
—
0
0
195
1519
1.30
3.04
3.9
3.9
4.9
4.8
kpa
0.48
189
1465
520
4498
1.18
3.02
1.6
1.5
16481477.9
38701128.6
pmol/l
0.61
449
3956
40
226
1.78
2.98
1.9
1.9
—
—
—
0
0
2995
28998
1.14
2.95
3.2
3.2
4.7
4.7
mmol/l
0.59
2861
27727
107
764
1.41
2.94
1.2
1.2
—
—
—
0
0
42
242
1.74
2.93
2.9
2.9
0.2
0.2
e9/l
0.03
36
199
217
1725
1.27
2.90
6.8
7.1
1.4
1.4
mmol/l
0.22
201
1653
2545
24412
1.12
2.90
3.8
3.8
36.8
37.2
mmol/mol
1.75
2417
23226
37
206
1.80
2.90
2.2
1.6
—
—
—
0
0
375
3169
1.20
2.85
1.2
1.2
—
—
—
0
0
43
252
1.71
2.84
1.3
1.2
—
—
—
0
0
49
299
1.65
2.80
1.0
1.0
—
—
—
0
0
40
231
1.74
2.79
6.0
6.5
9.4
9.9
mg/l
0.29
35
209
16
65
2.47
2.78
1.0
1.2
—
—
—
0
0
88
614
1.44
2.76
2.6
2.6
—
—
—
0
0
2857
27622
1.12
2.75
3.0
2.9
1.3
1.2
mmol/l
1.75
2729
26371
13
48
2.71
2.71
1.2
1.8
—
—
—
0
0
154
1182
1.32
2.71
2.2
2.4
4.2
5.2
umol/l
1.25
109
882
1532
14333
1.11
2.70
4.2
3.8
—
—
—
0
0
167
1301
1.30
2.64
1.8
1.7
—
—
—
0
0
39
229
1.71
2.59
1.2
1.2
—
—
—
0
0
96
690
1.40
2.58
3.4
2.6
—
—
—
0
0
48
301
1.60
2.50
1.2
1.3
—
—
—
0
0
94
678
1.40
2.49
1.1
1.1
2.8
2.6
u/ml
0.08
54
365
41
247
1.67
2.49
1.1
1.1
6.1
6.2
iu/ml
0.02
14
57
7
16
4.38
2.47
1.4
1.5
—
—
—
0
0
8
21
3.81
2.46
1.0
1.7
—
—
—
0
0
2968
28823
1.12
2.45
3.2
3.1
1.4
1.4
mmol/l
1.77
2823
27498
24
123
1.96
2.45
1.2
1.1
3.8
4.5
iu/ml
—
5
11
45
280
1.61
2.42
1.4
1.6
—
—
—
0
0
45
280
1.61
2.42
1.4
1.6
—
—
—
0
0
45
280
1.61
2.42
1.4
1.6
—
—
—
0
0
45
280
1.61
2.42
1.4
1.6
—
—
—
0
0
31
174
1.79
2.41
3.2
4.5
11.1
11.7
%
0.41
31
174
2997
29130
1.12
2.40
3.3
3.3
2.8
2.9
mmol/l
0.39
2841
27649
6
12
5.01
2.40
2.2
4.9
—
—
—
0
0
409
3543
1.17
2.37
2.2
2.2
—
—
—
0
0
41
251
1.64
2.36
3.0
2.8
570.5
507.2
e6/l
0.45
35
200
350
3002
1.18
2.29
2.2
2.3
—
—
—
0
0
6
13
4.62
2.27
2.0
4.7
—
—
—
0
0
91
665
1.38
2.26
1.2
1.1
—
—
—
0
0
7
18
3.89
2.25
1.6
1.4
—
—
—
0
0
78
556
1.41
2.24
1.3
1.3
—
—
—
0
0
48
310
1.56
2.24
4.3
2.8
17.0
2.9
ratio
—
8
39
32
186
1.73
2.24
1.7
1.5
—
—
—
0
0
327
2795
1.19
2.24
6.5
6.0
1.1
1.1
mmol/l
0.14
311
2636
742
6732
1.13
2.22
3.1
2.9
—
—
—
0
0
206
1688
1.23
2.19
10.6
8.2
7.3
7.1
mmol/l
0.29
199
1622
439
3856
1.16
2.14
2.2
2.2
—
—
—
0
0
19
360
0.53
2.14
8.3
15.1
629.8
795.1
nmol/l
0.87
19
348
30
174
1.73
2.13
1.7
1.6
45.0
36.8
%
0.54
25
116
364
3154
1.17
2.12
1.2
1.2
65.2
157.2
iu/ml
8.48
112
1181
76
548
1.39
2.07
4.0
3.2
8.9
9.2
kpa
0.65
71
514
1326
12450
1.10
2.06
2.1
2.1
—
—
—
0
0
48
317
1.52
2.05
4.3
2.8
82.8
71.8
mg/l
0.11
37
258
48
317
1.52
2.05
4.3
2.8
30.7
30.1
mg/l
0.05
36
256
434
3822
1.15
2.05
2.1
2.2
—
—
—
0
0
58
399
1.46
2.04
1.2
1.1
50.1
38.4
mg/l
0.70
47
320
105
799
1.32
2.04
2.1
2.0
1.4
1.3
g/l
0.17
90
705
1288
12088
1.10
2.01
1.8
1.7
—
—
—
0
0
218
1815
1.21
2.01
9.2
11.5
1.1
1.1
inr
0.05
34
314
20
365
0.55
2.01
11.8
22.1
1141.3
1373.9
nmol/l
0.53
20
353
461
4085
1.15
2.00
1.5
1.5
—
—
—
0
0
436
3849
1.15
2.00
2.1
2.1
—
—
—
0
0
50
336
1.49
1.98
2.0
1.4
—
—
—
0
0
7
21
3.34
1.96
1.1
1.0
—
—
—
0
0
40
257
1.56
1.94
1.4
1.3
125.0
203.3
titre
—
8
55
726
6635
1.12
1.91
2.3
2.1
2.7
2.7
mg/l
0.37
629
5715
81
600
1.36
1.90
1.2
1.3
3.4
4.1
u/ml
0.36
39
272
18
92
1.96
1.89
1.5
1.6
4.9
5.0
%
—
7
23
3112
30426
1.11
1.89
12.8
11.5
334.4
334.1
g/l
1.39
3093
30160
352
3075
1.16
1.87
1.4
1.5
—
—
—
0
0
427
3783
1.14
1.87
2.2
2.1
—
—
—
0
0
152
1229
1.25
1.87
1.5
1.6
—
—
—
0
0
188
1556
1.22
1.86
1.1
1.1
—
—
—
0
0
948
8803
1.10
1.83
2.4
2.0
—
—
—
0
0
5
12
4.17
1.82
1.0
1.0
—
—
—
0
0
5
12
4.17
1.82
27.4
2.8
—
—
—
0
0
54
377
1.44
1.80
1.5
1.5
39.0
39.3
g/l
0.12
47
344
173
1426
1.22
1.79
1.7
2.2
31.1
32.8
u/ml
0.07
167
1374
47
320
1.47
1.78
3.3
2.1
—
—
—
0
0
152
1237
1.24
1.78
1.1
1.1
3.0
4.7
u/ml
0.69
30
190
55
387
1.43
1.76
1.1
1.1
261.3
231.7
mg/l
0.24
45
330
5
13
3.85
1.71
1.2
1.0
—
—
—
0
0
81
614
1.33
1.67
1.2
1.2
—
—
—
0
0
98
764
1.29
1.66
1.3
1.3
2.0
4.3
u/ml
—
10
79
15
76
1.98
1.64
1.1
1.1
—
—
—
0
0
99
775
1.28
1.63
1.3
1.3
7.7
12.9
u/ml
0.41
16
112
55
394
1.40
1.62
1.4
1.6
—
—
—
0
0
37
245
1.52
1.62
5.0
2.9
—
—
—
0
0
59
428
1.38
1.62
3.9
3.9
—
—
—
0
0
17
91
1.87
1.60
1.8
3.2
7.4
7.4
ph
—
5
21
52
370
1.41
1.60
1.5
1.7
—
—
—
0
0
228
1953
1.18
1.59
4.3
3.3
—
—
—
0
0
81
620
1.31
1.58
1.4
1.4
326.2
312.3
ug/g
0.24
42
307
69
518
1.34
1.54
3.8
3.9
117.3
2516.1
u/ml
0.66
58
437
44
306
1.44
1.53
1.0
1.3
—
—
—
0
0
8
33
2.43
1.53
2.4
2.1
—
—
—
0
0
100
791
1.27
1.53
1.3
1.4
15.6
16.4
u/l
0.11
82
683
120
970
1.24
1.53
1.1
1.1
3.8
4.7
u/ml
0.27
65
399
97
765
1.27
1.52
1.1
1.1
0.0
0.4
u/ml
2.70
25
173
5
15
3.34
1.52
1.6
1.2
2.7
3.9
mmol/l
—
5
15
5
15
3.34
1.52
1.0
2.1
—
—
—
0
0
110
882
1.25
1.51
1.1
1.1
5.4
7.1
u/ml
0.42
60
396
6
21
2.86
1.50
1.0
1.0
—
—
—
0
0
16
86
1.86
1.50
2.4
2.1
—
—
—
0
0
72
547
1.32
1.49
1.9
1.7
0.6
0.7
g/l
1.00
56
415
9
37
2.44
1.47
1.0
1.9
—
—
—
0
0
109
876
1.25
1.47
3.0
3.6
0.2
0.4
g/l
1.19
63
422
37
251
1.48
1.47
1.2
1.1
1656.7
1532.9
miu/ml
0.25
37
251
286
2512
1.15
1.47
1.3
1.4
19.8
18.2
iu/l
0.44
237
2093
86
672
1.29
1.46
6.9
4.4
—
—
—
0
0
26
163
1.60
1.46
1.9
3.1
—
—
—
0
0
47
335
1.41
1.45
2.1
1.4
0.4
0.4
g/l
0.02
35
227
47
336
1.40
1.43
2.1
1.4
6.7
6.5
g/l
0.18
35
231
47
336
1.40
1.43
2.1
1.4
2.8
3.0
g/l
0.25
35
230
66
500
1.33
1.41
2.9
2.1
135.6
135.2
g/l
0.04
52
386
23
142
1.62
1.38
5.4
3.1
—
—
—
0
0
28
182
1.54
1.37
5.0
3.1
220.2
179.6
umol/l
0.15
12
101
46
332
1.39
1.34
1.3
1.2
—
—
—
0
0
29
191
1.52
1.34
4.9
2.9
—
—
—
0
0
14
75
1.87
1.34
1.1
1.1
—
—
—
0
0
38
265
1.44
1.34
1.1
1.2
—
—
—
0
0
9
42
2.15
1.33
1.4
1.2
—
—
—
0
0
83
655
1.27
1.33
2.5
2.5
426.8
312.5
ug/l
0.19
74
590
109
892
1.23
1.29
1.7
2.1
3.8
4.3
iu/l
0.36
42
360
63
482
1.31
1.28
1.3
1.6
—
—
—
0
0
193
1666
1.17
1.28
1.5
1.4
—
—
—
0
0
54
405
1.34
1.26
2.1
2.1
—
—
—
0
0
201
1744
1.16
1.25
1.1
1.1
—
—
—
0
0
14
77
1.82
1.25
1.4
1.3
—
—
—
0
0
49
363
1.35
1.24
1.9
1.9
—
—
—
0
0
61
468
1.31
1.23
1.1
1.4
—
—
—
0
0
18
108
1.67
1.22
1.1
1.1
—
—
—
0
0
734
6866
1.08
1.21
3.2
3.0
1.0
1.0
kg/l
0.15
103
1002
145
1229
1.19
1.21
2.0
2.3
4.2
6.5
ug/l
1.86
129
1090
712
6653
1.09
1.21
2.2
2.0
—
—
—
0
0
297
2655
1.13
1.21
1.7
1.6
—
—
—
0
0
16
93
1.72
1.21
1.3
1.5
37.8
34.2
g/l
0.54
16
82
226
1988
1.15
1.18
1.4
1.4
10.1
8.0
u/l
1.39
190
1638
205
1794
1.15
1.16
3.0
3.0
—
—
—
0
0
13
72
1.81
1.15
1.2
2.9
—
—
—
0
0
12
65
1.85
1.13
1.3
1.3
—
—
—
0
0
189
1648
1.15
1.13
1.3
1.4
—
—
—
0
0
506
4678
1.09
1.11
1.4
1.4
18.8
20.0
nmol/l
1.58
460
4208
307
2767
1.12
1.11
1.5
1.6
334.1
301.3
mu/l
0.61
278
2488
150
1288
1.17
1.10
3.7
4.2
6.0
45.3
ug/l
0.78
109
932
11
59
1.87
1.07
1.1
1.1
—
—
—
0
0
11
59
1.87
1.07
1.5
1.3
—
—
—
0
0
11
59
1.87
1.07
1.1
1.1
—
—
—
0
0
11
59
1.87
1.07
1.1
1.1
—
—
—
0
0
265
2374
1.12
1.07
1.4
1.3
232.0
230.4
miu/ml
0.02
133
1180
5
22
2.27
1.03
1.0
1.7
—
—
—
0
0
5
22
2.27
1.03
1.0
1.2
—
—
—
0
0
5
22
2.27
1.03
1.2
1.3
—
—
—
0
0
307
2781
1.11
1.03
2.6
2.1
12.6
11.9
nmol/l
0.80
283
2520
49
376
1.31
1.02
2.1
3.4
—
—
—
0
0
7
34
2.06
1.02
1.1
1.2
—
—
—
0
0
26
179
1.46
1.02
2.5
2.7
37.5
43.8
%
—
5
59
361
3302
1.10
1.01
1.2
1.2
—
—
—
0
0
22
147
1.50
1.00
1.9
2.2
30.5
29.0
%
0.22
22
142
107
902
1.19
0.99
2.0
2.1
—
—
—
0
0
369
3383
1.10
0.99
1.3
1.3
—
—
—
0
0
545
5087
1.08
0.97
4.6
4.2
11.2
12.1
mg/mmol
0.18
377
3493
7
36
1.95
0.97
1.1
1.1
—
—
—
0
0
15
92
1.63
0.97
2.8
2.9
—
—
—
0
0
524
4885
1.08
0.97
3.7
3.4
295.9
353.2
mg/l
0.14
365
3332
27
190
1.42
0.96
1.1
1.1
7.2
8.7
u/ml
0.09
19
118
8
42
1.91
0.88
18.5
6.7
—
—
—
0
0
8
43
1.86
0.87
1.3
1.1
—
—
—
0
0
6
114
0.53
0.82
1.0
1.4
19.3
36.7
mmol/l
—
6
109
185
1656
1.12
0.81
8.8
8.9
95.6
96.5
%
0.80
179
1593
138
1213
1.14
0.80
1.3
1.3
—
—
—
0
0
120
1045
1.15
0.80
3.3
2.7
100.7
114.3
ng/l
0.30
95
903
209
1889
1.11
0.78
8.0
8.3
13.3
13.7
kpa
0.48
201
1809
209
1889
1.11
0.78
8.0
8.3
4.9
5.0
kpa
0.76
201
1807
31
234
1.33
0.77
1.7
1.7
46.8
49.3
%
0.13
24
162
17
115
1.48
0.76
1.1
1.1
—
—
—
0
0
6
34
1.77
0.76
2.3
3.1
—
—
—
0
0
14
91
1.54
0.75
3.4
2.8
—
—
—
0
0
26
192
1.36
0.75
1.4
1.3
1.5
1.5
nmol/l
0.09
21
177
105
912
1.16
0.74
1.6
1.6
—
—
—
0
0
56
460
1.22
0.73
1.6
1.5
11.6
11.5
mmol/l
—
6
66
19
133
1.43
0.73
2.0
2.2
193.8
180.6
e6/l
0.10
13
71
16
108
1.48
0.73
1.4
1.2
25.2
15.4
%
—
6
9
22
159
1.39
0.72
1.9
2.5
12.9
9.5
%
0.37
22
153
20
142
1.41
0.72
1.6
1.9
—
—
—
0
0
5
26
1.92
0.70
2.6
1.9
94.0
120.2
ng/l
—
5
26
5
26
1.92
0.70
1.2
3.9
—
—
—
0
0
24
177
1.36
0.70
1.5
1.4
5.2
6.4
u/l
0.84
19
145
26
195
1.34
0.69
2.2
3.8
—
—
—
0
0
115
1012
1.14
0.69
8.7
7.8
24.5
24.1
mmol/l
0.51
107
937
195
1773
1.11
0.68
2.7
2.3
—
—
—
0
0
29
222
1.31
0.68
3.2
3.0
—
—
—
0
0
29
222
1.31
0.68
6.5
6.0
—
—
—
0
0
20
144
1.39
0.67
2.1
2.2
1.1
1.5
nmol/l
1.27
13
116
33
258
1.28
0.67
1.7
1.6
5.6
5.8
mmol/l
0.18
25
211
117
1036
1.13
0.65
1.1
1.2
—
—
—
0
0
39
313
1.25
0.65
1.1
1.0
—
—
—
0
0
71
606
1.17
0.64
1.8
1.8
—
—
—
0
0
25
189
1.32
0.64
1.2
1.2
—
—
—
0
0
43
524
0.82
0.63
1.3
1.3
—
—
—
0
0
5
30
1.67
0.61
5.8
5.1
—
—
—
0
0
67
573
1.17
0.60
2.6
2.8
21.9
23.3
mg/l
0.15
41
351
0
20
0.00
0.60
0.0
1.0
—
0.2
—
0
9
22
165
1.34
0.60
1.0
1.1
—
—
—
0
0
148
1338
1.11
0.59
4.0
4.2
68.8
71.6
ng/l
0.24
137
1227
30
236
1.27
0.59
3.9
3.7
7.6
8.7
mg/l
0.51
24
192
0
22
0.00
0.59
0.0
1.1
—
0.6
—
0
5
0
22
0.00
0.59
0.0
1.1
—
—
—
0
0
49
409
1.20
0.58
3.1
2.8
—
—
—
0
0
8
53
1.51
0.58
1.4
1.1
—
—
—
0
0
33
264
1.25
0.58
1.1
1.1
331.0
286.1
mg/l
1.18
27
242
31
387
0.80
0.57
1.1
1.1
—
—
—
0
0
18
132
1.37
0.57
2.6
2.0
—
—
—
0
0
6
37
1.62
0.55
1.2
1.2
—
—
—
0
0
12
82
1.46
0.54
1.3
1.5
—
—
—
0
0
19
143
1.33
0.52
3.1
1.9
—
—
—
0
0
204
1889
1.08
0.52
8.2
8.3
0.9
0.6
mmol/l
0.51
149
1416
43
360
1.20
0.51
1.0
1.1
0.4
2.2
u/ml
1.14
11
118
32
260
1.23
0.51
1.4
1.3
0.4
0.6
u/ml
0.19
12
75
68
593
1.15
0.51
1.1
1.1
117.7
2329.0
iu/ml
0.74
25
174
127
1153
1.10
0.50
1.1
1.1
1.0
2.5
u/ml
2.78
44
314
204
1895
1.08
0.49
1.2
1.2
—
—
—
0
0
21
268
0.78
0.49
3.6
3.1
—
—
—
0
0
7
46
1.52
0.48
11.1
4.8
—
—
—
0
0
16
119
1.35
0.48
1.0
1.0
—
—
—
0
0
7
48
1.46
0.46
1.1
1.1
—
—
—
0
0
15
111
1.35
0.46
1.3
1.4
—
—
—
0
0
169
1563
1.08
0.46
8.2
9.3
125.8
125.7
g/l
0.01
163
1505
322
3049
1.06
0.46
1.2
1.3
—
—
—
0
0
69
608
1.14
0.46
3.9
6.7
1.3
1.2
mmol/l
0.69
63
532
7
49
1.43
0.46
1.3
1.1
—
6.0
—
0
6
17
129
1.32
0.45
4.8
3.1
18.8
42.4
u/ml
1.17
17
129
124
1132
1.10
0.45
1.1
1.1
1.4
1.5
u/ml
0.03
60
522
114
1037
1.10
0.45
1.4
1.5
0.3
0.5
nmol/l
3.79
91
851
10
69
1.45
0.44
1.6
1.6
—
—
—
0
0
145
1336
1.09
0.44
1.1
1.1
1.6
2.0
u/ml
0.22
70
586
33
275
1.20
0.43
1.1
1.1
1.1
1.1
ratio
0.21
11
108
5
31
1.61
0.43
1.0
1.3
1.6
1.1
mmol/l
—
5
31
8
56
1.43
0.42
2.1
1.5
—
—
—
0
0
5
32
1.56
0.42
1.0
1.3
—
24.1
—
0
11
5
32
1.56
0.42
1.0
1.3
—
27.5
—
0
10
5
33
1.52
0.41
3.2
3.7
—
5.2
—
0
8
0
16
0.00
0.41
0.0
1.1
—
32.8
—
0
16
0
17
0.00
0.40
0.0
1.2
—
68.8
—
0
17
26
214
1.22
0.39
1.3
1.4
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
19.6
—
0
13
14
106
1.32
0.39
1.3
1.1
—
—
—
0
0
23
187
1.23
0.39
1.2
1.2
—
—
—
0
0
22
178
1.24
0.38
1.0
1.1
—
—
—
0
0
5
36
1.39
0.38
1.2
1.1
—
—
—
0
0
49
429
1.14
0.38
2.3
2.3
—
—
—
0
0
9
67
1.34
0.38
6.2
5.6
25.3
43.3
g/mol
—
9
61
9
67
1.34
0.38
3.4
4.9
24.1
24.9
mmol/l
—
9
62
13
98
1.33
0.37
1.2
1.2
—
—
—
0
0
19
152
1.25
0.37
3.1
2.8
—
—
—
0
0
467
4500
1.04
0.36
2.1
2.0
—
—
—
0
0
60
535
1.12
0.36
1.9
1.5
—
—
—
0
0
24
198
1.21
0.36
1.2
1.4
—
—
—
0
0
21
171
1.23
0.35
1.6
2.5
18.3
186.9
ug/l
0.74
21
153
13
99
1.31
0.35
1.3
1.2
—
—
—
0
0
6
44
1.36
0.34
1.0
1.2
—
—
—
0
0
112
1036
1.08
0.34
2.7
2.4
—
—
—
0
0
128
1193
1.08
0.33
1.1
1.1
9.3
7.6
u/ml
0.42
76
684
16
128
1.25
0.31
1.2
1.2
—
—
—
0
0
16
128
1.25
0.31
2.1
2.4
1997.6
2172.6
ml
0.37
16
123
12
92
1.31
0.31
1.1
2.6
—
—
—
0
0
29
337
0.86
0.31
3.6
4.1
147.2
69.3
u/ml
—
9
104
21
175
1.20
0.30
1.0
1.1
0.2
5.0
nmol/l
—
5
33
90
832
1.08
0.29
7.8
7.0
—
—
—
0
0
96
890
1.08
0.29
10.0
10.4
23.9
24.0
mmol/l
0.13
87
849
13
163
0.80
0.29
6.2
7.1
—
—
—
0
0
7
57
1.23
0.29
1.0
1.4
55.1
46.7
%
—
7
52
44
394
1.12
0.27
4.2
2.5
—
—
—
0
0
20
168
1.19
0.27
1.2
1.2
—
—
—
0
0
25
289
0.86
0.26
3.0
2.7
6.7
6.9
mmol/l
0.16
25
284
8
67
1.19
0.26
1.9
1.8
—
—
—
0
0
13
160
0.81
0.26
1.5
2.1
—
—
—
0
0
19
160
1.19
0.25
1.1
1.2
—
—
—
0
0
105
985
1.07
0.25
6.6
5.9
—
—
—
0
0
36
321
1.12
0.24
1.4
1.5
388.9
377.4
pmol/l
0.09
31
258
50
456
1.10
0.23
3.1
2.9
32.1
33.0
umol/l
0.12
43
397
629
6422
0.98
0.22
1.6
1.6
1.4
1.4
mmol/l
0.32
540
5696
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
14
117
1.20
0.20
1.5
1.7
—
—
—
0
0
218
2259
0.96
0.20
1.6
1.5
—
—
—
0
0
25
221
1.13
0.20
1.4
1.2
—
—
—
0
0
39
356
1.10
0.19
1.5
1.6
—
—
—
0
0
225
2325
0.97
0.18
1.6
1.5
—
—
—
0
0
10
81
1.24
0.18
1.2
1.5
—
—
—
0
0
21
238
0.88
0.18
1.3
1.5
105.0
72.5
mmol/l
1.41
15
202
67
714
0.94
0.18
2.0
1.8
13.0
13.0
%
0.24
67
708
12
100
1.20
0.18
1.0
1.1
—
—
—
0
0
111
1060
1.05
0.17
12.3
10.0
93.3
94.4
%
0.66
111
1054
8
68
1.18
0.16
1.6
1.4
—
—
—
0
0
40
369
1.08
0.16
1.1
1.1
2.2
2.7
u/ml
—
10
101
8
69
1.16
0.16
2.1
1.3
145.6
121.1
nmol/l
—
8
51
38
350
1.09
0.16
1.1
1.0
1.2
2.0
u/ml
—
5
58
14
162
0.86
0.16
1.5
1.2
—
—
—
0
0
71
671
1.06
0.16
1.8
1.8
—
—
—
0
0
25
225
1.11
0.16
2.1
2.0
—
—
—
0
0
220
2264
0.97
0.15
1.6
1.5
—
—
—
0
0
12
102
1.18
0.15
1.3
2.0
—
—
—
0
0
138
1429
0.96
0.14
1.2
1.2
—
—
—
0
0
15
131
1.15
0.14
1.1
1.2
—
—
—
0
0
42
449
0.93
0.13
1.3
1.7
16186.5
12453.6
e6/l
0.31
33
334
13
113
1.15
0.13
4.4
4.5
—
—
—
0
0
29
314
0.92
0.12
1.3
1.5
—
—
—
0
0
19
172
1.11
0.11
3.8
2.9
104.8
48.9
mg/l
0.58
13
122
12
105
1.14
0.11
1.0
1.0
—
—
—
0
0
38
358
1.06
0.10
1.6
1.5
1.3
1.4
promille
0.13
27
268
12
106
1.13
0.09
1.2
1.1
—
—
—
0
0
20
184
1.09
0.09
1.3
1.4
75.0
79.1
%
—
5
20
6
55
1.09
0.08
1.2
1.0
—
—
—
0
0
377
3722
1.01
0.08
1.4
1.4
—
—
—
0
0
10
113
0.88
0.08
1.5
1.1
—
—
—
0
0
5
62
0.81
0.08
1.4
1.2
—
—
—
0
0
551
5460
1.01
0.07
1.3
1.3
—
—
—
0
0
16
147
1.09
0.07
2.8
1.8
1.7
2.2
u/field
—
6
86
7
85
0.82
0.07
3.7
2.4
0.8
0.9
nmol/l
—
7
59
52
536
0.97
0.05
1.2
1.4
37.4
32.2
nmol/l
0.39
47
492
51
525
0.97
0.05
1.6
2.5
0.9
0.8
nmol/l
0.48
43
448
288
2853
1.01
0.05
1.5
1.4
—
—
—
0
0
92
936
0.98
0.04
10.8
11.2
—
—
—
0
0
134
1323
1.01
0.03
1.3
1.3
3.6
4.0
ug/l
0.31
128
1261
31
321
0.97
0.03
2.7
2.6
1.3
1.5
mmol/l
1.01
31
311
33
320
1.03
0.03
1.0
1.0
—
—
—
0
0
12
112
1.07
0.03
1.1
1.2
—
4.5
—
0
24
12
128
0.94
0.02
2.3
2.0
14.7
14.6
umol/l
0.01
12
128
25
259
0.97
0.02
3.6
6.3
6.4
6.8
mmol/l
0.35
19
209
54
530
1.02
0.02
1.1
1.1
—
—
—
0
0
14
147
0.95
0.01
1.1
1.1
—
—
—
0
0
21
204
1.03
0.00
1.1
1.1
—
—
—
0
0
13
125
1.04
0.00
2.1
1.6
—
—
—
0
0
16
155
1.03
0.00
1.1
1.1
—
—
—
0
0
22
225
0.98
0.00
1.1
1.0
—
7.6
—
0
26
44
445
0.99
0.00
2.6
2.7
192.2
120.2
ug/min
0.36
28
306
107
1065
1.00
0.00
12.7
9.9
0.7
0.7
%
0.28
107
1056
13
131
0.99
0.00
1.6
1.5
135.3
134.7
nmol/l
0.03
13
131
15
153
0.98
0.00
1.8
1.5
—
2205.2
—
0
26
5
57
0.88
0.00
2.0
1.5
—
—
—
0
0
5
56
0.89
0.00
2.2
1.4
—
—
—
0
0
5
58
0.86
0.00
2.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
77.4
—
0
9
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
96.8
—
0
6
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
5
49
1.02
0.00
1.4
1.6
—
—
—
0
0
6
65
0.92
0.00
1.3
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
125.2
—
0
7
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
33
330
1.00
0.00
1.2
1.4
82.5
148.0
pmol/l
0.32
11
103
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
8
87
0.92
0.00
1.4
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
2.3
—
0
8

Mortality – FinRegistry

Association

Association between endpoint AB1_EBV and mortality.

Females

Parameter HR [95% CI] p-value
AB1_EBV 1.492 [1.12, 1.99] 0.006
Birth year 1.0 [0.99, 1.01] 0.947

During the follow-up period (1.1.1998 — 31.12.2019), 118 out of 16191 females with AB1_EBV died.

Males

Parameter HR [95% CI] p-value
AB1_EBV 1.411 [1.2, 1.65] < 0.001
Birth year 0.987 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 218 out of 14786 males with AB1_EBV died.

Mortality risk

Mortality risk for people of age

years, who have AB1_EBV.

N-year risk Females Males
1 0.208% 0.257%
5 1.039% 1.587%
10 2.769% 4.122%
15 5.219% 7.827%
20 8.95% 12.79%

Relationships between endpoints

Index endpoint: AB1_EBV – Infectious mononucleosis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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