Benign neoplasm: Pituitary gland, craniopharyngeal duct

CD2_BENIGN_PITUITARY_CRANIPHAR

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D35.2&, D35.3
  • Hospital discharge: ICD-9 2273
  • Hospital discharge: ICD-8 2262
  • Cause of death: ICD-10 D35.2&, D35.3
  • Cause of death: ICD-9 2273
  • Cause of death: ICD-8 2262

2 out of 7 registries used, show all original rules.

2082

4. Check minimum number of events

None

2082

5. Include endpoints

None

2082

6. Filter based on genotype QC (FinnGen only)

2009

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 10221 5749 4361
Only index persons 9206 5345 3861
Unadjusted period prevalence (%)
Whole population 0.15 0.16 0.12
Only index persons 0.18 0.20 0.15
Median age at first event (years)
Whole population 50.74 47.54 55.24
Only index persons 49.72 46.32 54.42

-FinnGen-

Key figures

All Female Male
Number of individuals 2009 1171 838
Unadjusted period prevalence (%) 0.40 0.42 0.38
Median age at first event (years) 51.27 47.64 56.34

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
2082
Matched controls
20820
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
ZXC86
NOMESCO Finland
Use of endoscopic device
117.0
307.7
201
19
101
Kela drug reimbursment
Anterior pituitary hypofunction
130.1
307.7
383
36
E22.1
ICD-10 Finland
Hyperprolactinaemia
166.1
307.7
455
35
N04BC06
ATC
cabergoline; oral
290.1
307.7
399
17
E23.00
ICD-10 Finland
Panhypopituitarism
581.8
307.7
383
8
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
304.8
307.7
839
46
H02AB09
ATC
hydrocortisone; systemic
63.7
307.7
722
172
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
4503599627370496.0
307.7
1798
*
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
2351.9
307.7
643
*
D44.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pituitary gland
640.8
288.3
279
5
D35.31
ICD-10 Finland
Cyst in Rathke's pocket
+∞
282.9
265
*
G02CB01
ATC
bromocriptine; systemic
17.4
258.5
219
140
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
8.1
249.1
373
549
XCK00
NOMESCO Finland
Perimetry
8.1
247.1
368
538
E23.05
ICD-10 Finland
Lack of TSH
94.1
237.4
124
14
H53.4
ICD-10 Finland
Visual field defects
15.6
228.9
205
145
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
352.3
220.3
219
7
H03AA01
ATC
levothyroxine sodium; systemic
4.2
219.0
873
3031
G02CB03
ATC
cabergoline; oral
46.6
215.5
127
29
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
14.8
215.0
198
147
E23.2
ICD-10 Finland
Diabetes insipidus
92.9
170.0
89
10
E22.0
ICD-10 Finland
Acromegaly and pituitary gigantism
582.8
165.5
162
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
7.7
154.0
228
326
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
8.4
153.0
210
275
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
18.3
151.7
123
71
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
8.1
146.6
206
277
AA4CM
NOMESCO Finland
Extensive MRI examination of sella turcica with 3 Tesla magnet
501.2
143.2
141
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.5
132.2
604
2191
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.6
131.8
361
915
102
Kela drug reimbursment
Diabetes insipidus
161.5
130.0
136
9
ZXC95
NOMESCO Finland
Use of surgical navigator
14.2
126.2
117
87
H01AC01
ATC
somatropin; parenteral
35.1
107.6
68
20
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
34.6
105.5
67
20
AA4DG
NOMESCO Finland
Very extensive MRI examination of sella turcica with high intensity magnet
129.0
103.1
110
9
2273A
ICD-9 Finland
Benign neoplasm of other endocrine glands and related structures, Pituitary gland and craniopharyngeal duct (pouch)
+∞
101.9
97
*
E23.03
ICD-10 Finland
Lack of ACTH
49.7
99.9
58
12
D35.30
ICD-10 Finland
Craniopharyngoma
+∞
90.3
86
*
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
16.0
89.2
77
50
D35.0
ICD-10 Finland
Benign neoplasm: Adrenal gland
9.6
86.3
103
112
H01CB03
ATC
lanreotide; parenteral
50.2
84.5
49
10
H01CB02
ATC
octreotide; parenteral
39.4
81.5
50
13
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.9
78.8
463
1884
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
11.0
77.1
83
78
CS494
NOMESCO Finland
Other visual field testing
6.7
74.3
122
193
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.2
63.9
288
1002
E24.0
ICD-10 Finland
Pituitary-dependent Cushing disease
136.3
62.2
66
5
2542
FHL
Transasal hypophysectomy
+∞
60.7
58
*
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
11.9
58.7
60
52
AA1AD
NOMESCO Finland
CT of head and brain
2.2
53.3
623
3404
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
9.1
52.1
64
72
H47.2
ICD-10 Finland
Optic atrophy
17.1
50.6
42
25
301
Kela drug reimbursment
Growth hormone
110.8
50.0
54
5
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
7.9
48.6
67
87
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
48.1
620
3497
R51.80
ICD-10 Finland
Headache
2.3
47.6
426
2074
22620
ICD-8 Finland
Benign neoplasm of endocrine glands, Pituitary gland and craniopharyngeal duct (pouch)
+∞
46.0
44
*
WX882
NOMESCO Finland
High dependency care
5.0
46.0
100
206
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.8
45.5
259
1017
E23.09
ICD-10 Finland
Pituitary insufficiency NOS
85.4
45.0
50
6
E89.30
ICD-10 Finland
Postprocedural hypopituitarism
229.8
44.1
45
*
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.6
44.0
280
1163
T99
ICPC
Endocr/metab/nutrit disease other
6.3
41.3
70
114
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.6
40.1
268
1137
Y28
ICPC
Limited function/disability (Y)
15.5
40.0
35
23
9350/1-C75.2
ICD-O-3
Craniopharyngioma, NOS, of craniopharyngeal duct
+∞
39.7
38
*
N91.1
ICD-10 Finland
Secondary amenorrhoea
6.1
39.1
69
117
E23.6
ICD-10 Finland
Other disorders of pituitary gland
107.1
38.8
42
*
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
5.9
38.6
70
122
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
11.7
37.0
38
33
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
3.6
36.1
123
356
G02CB04
ATC
quinagolide; oral
363.4
36.1
36
*
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
12.3
35.1
35
29
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.3
34.3
302
1445
E24.9
ICD-10 Finland
Cushing syndrome, unspecified
77.5
33.9
38
5
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.9
32.9
168
620
UDM02
NOMESCO Finland
Sinoscopy
4.3
31.6
82
195
Z3231
NOMESCO Finland
Registered nurse
1.8
30.8
587
3687
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
4.4
30.4
78
184
2370A
ICD-9 Finland
Neoplasm of uncertain behaviour of endocrine glands and nervous system, Pituitary gland and craniopharyngeal duct
+∞
30.3
29
*
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
4.5
29.6
74
171
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
7.3
29.3
43
60
E22.9
ICD-10 Finland
Hyperfunction of pituitary gland, unspecified
+∞
29.2
28
*
ZXE20
NOMESCO Finland
More than three and less than five hours
2.1
28.9
306
1570
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
6.1
27.2
47
78
R42
ICD-10 Finland
Dizziness and giddiness
1.8
26.7
463
2807
E23
ICD-10 Finland
Hypofunction and other disorders of pituitary gland
141.8
26.7
28
*
H02AA02
ATC
fludrocortisone; oral
8.2
25.7
34
42
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
25.5
729
5077
G47.3
ICD-10 Finland
Sleep apnoea
1.8
25.2
486
3037
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
21.6
23.5
34
16
E23.0
ICD-10 Finland
Hypopituitarism
84.4
22.7
25
*
TAB00
NOMESCO Finland
Lumbar puncture
2.7
22.2
120
456
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.2
22.0
194
923
25320
ICD-8 Finland
Diseases of pituitary gland, Chromophobe adenoma, pituitary
+∞
21.9
21
*
ZXA10
NOMESCO Finland
Bilateral
1.8
21.0
365
2200
G44.2
ICD-10 Finland
Tension-type headache
1.9
20.3
302
1734
WX402
NOMESCO Finland
General anaesthesia
1.7
19.8
444
2870
D352, E221,
ICD-10 Finland
+∞
19.8
19
*
2530A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Acromegaly and gigantism[ACROMEGALIA]
+∞
19.8
19
*
E23.08
ICD-10 Finland
Hypopituitarism
74.2
19.7
22
*
WX110
NOMESCO Finland
Infiltration anesthesia
1.6
19.6
1462
12456
V04CD01
ATC
metyrapone; oral
201.8
19.6
20
*
D44.8
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pluriglandular involvement
40.5
19.5
24
6
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.4
19.4
141
617
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
3.5
19.4
66
191
105
Kela drug reimbursment
Adrenal cortical hypofunction
31.6
19.3
25
8
TAA40
NOMESCO Finland
Cathetrisation of cerebrospinal fluid through skin
26.3
19.1
26
10
121
Kela drug reimbursment
Severe hypofunction of sexual glands
3.7
18.5
58
159
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.7
18.3
414
2676
YX8VG
NOMESCO Finland
Stereotactic MRI exmaination with high intensity magnet for dose design of radiotherapy
16.3
18.3
29
18
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
18.1
859
6600
AAK40
NOMESCO Finland
Closure of cerebrospinal fluid fistula
33.2
18.0
23
7
AA1BD
NOMESCO Finland
Extensive CT of head and brain
3.4
17.9
63
187
E23.7
ICD-10 Finland
Disorder of pituitary gland, unspecified
67.2
17.7
20
*
AA4DM
NOMESCO Finland
Very extensive MRI examination of sella turcica with 3 Tesla magnet
+∞
17.7
17
*
D35.9
ICD-10 Finland
Benign neoplasm: Endocrine gland, unspecified
181.5
17.5
18
*
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
21.1
17.3
25
12
ZXD10
NOMESCO Finland
Scheduled procedure
1.5
16.8
730
5479
E27.2
ICD-10 Finland
Addisonian crisis
63.9
16.7
19
*
E21.0
ICD-10 Finland
Primary hyperparathyroidism
3.9
16.7
48
124
A55
ICPC
General and Unspecified, Local injection/infiltration
4.4
16.2
40
92
A02BC02
ATC
pantoprazole; systemic
1.5
15.7
1317
11209
D35.3
ICD-10 Finland
Benign neoplasm: Craniopharyngeal duct
+∞
15.6
15
*
WVA30, ,
SPAT
2.3
15.5
115
508
D35.1
ICD-10 Finland
Benign neoplasm: Parathyroid gland
16.2
15.2
24
15
G96.0
ICD-10 Finland
Cerebrospinal fluid leak
28.8
15.2
20
7
9530/0-C70.0
ICD-O-3
Meningioma, NOS, of cerebral meninges
6.1
15.1
26
43
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.2
15.1
135
645
-50
ICPC
Medication/prescr/renewal
2.5
15.1
92
372
N75
ICPC
Benign neoplasm nervous system
45.3
15.1
18
*
E66.8
ICD-10 Finland
Other obesity
2.2
14.9
125
582
Z3229
NOMESCO Finland
Other healthcare associate professional
2.0
14.9
163
841
N02BE01
ATC
paracetamol; systemic, rectal
1.7
14.8
1784
16276
H53.1
ICD-10 Finland
Subjective visual disturbances
2.1
14.8
139
677
T73
ICPC
Neoplasm endocrine other/unspecified
31.9
14.8
19
6
N04BC01
ATC
bromocriptine; oral
57.1
14.8
17
*
ZYC01
NOMESCO Finland
Remote contact by phone
2.2
14.6
133
640
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
6.6
14.5
23
35
H47.4
ICD-10 Finland
Disorders of optic chiasm
151.0
14.5
15
*
R55
ICD-10 Finland
Syncope and collapse
1.9
14.2
198
1110
ZYC05
NOMESCO Finland
Non-real-time text-based remote communication
3.8
14.1
43
116
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
3.6
14.0
45
126
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
3.7
13.9
43
117
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
13.6
358
2388
2159
FHL
Other measure in this category
75.6
13.6
15
*
UJF32
NOMESCO Finland
Coloscopy
1.5
13.6
474
3373
D35.50
ICD-10 Finland
Carotid body
+∞
13.6
13
*
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
3.8
13.5
41
110
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
13.5
534
3899
2532A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Panhypopituitarism[PANHYPOPITUITARISMUS]
140.9
13.5
14
*
G03DB01
ATC
dydrogesterone; oral
1.7
13.5
245
1486
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
13.4
757
5922
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.6
13.3
346
2303
D44.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Adrenal gland
4.3
13.2
34
81
WF099
NOMESCO Finland
Other radiotherapy
6.0
13.1
23
39
R53
ICD-10 Finland
Malaise and fatigue
1.5
13.0
455
3234
D43.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, supratentorial
6.2
12.9
22
36
ZX050
NOMESCO Finland
Stereotactic radiotherapy
5.1
12.9
27
54
2531A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Other and unspecified anterior pituitary hyperfunction[HYPERPROLACTINAEMIA]
50.3
12.8
15
*
E89.6
ICD-10 Finland
Postprocedural adrenocortical(-medullary) hypofunction
50.3
12.8
15
*
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
1.9
12.8
169
930
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
12.7
807
6431
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
6.0
12.6
22
37
E24.8
ICD-10 Finland
Other Cushing syndrome
24.5
12.5
17
7
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
20.2
12.5
18
9
AA4AD
NOMESCO Finland
CT of sella turcica
130.8
12.4
13
*
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
12.4
424
2997
E03.89
ICD-10 Finland
Other specified hypothyroidism
2.4
12.4
82
345
R51
ICD-10 Finland
Headache
2.1
11.9
121
608
H53.2
ICD-10 Finland
Diplopia
2.5
11.7
73
299
J01DB01
ATC
cefalexin; oral
1.5
11.5
1649
14997
AA4BM
NOMESCO Finland
MRI examination of sella turcica with 3 Tesla magnet
+∞
11.5
11
*
AA4BD
NOMESCO Finland
Extensive CT of sella turcica
+∞
11.5
11
*
R11
ICD-10 Finland
Nausea and vomiting
1.8
11.1
165
942
BCA31
NOMESCO Finland
Endoscopic unilateral adrenalectomy
5.8
11.0
20
35
E89.39
ICD-10 Finland
Postprocedural hypopituitarism, other or several procedures
60.3
10.6
12
*
T28
ICPC
Limited function/disability (T)
4.4
10.5
26
60
N06AB10
ATC
escitalopram; oral
1.5
10.4
395
2842
M14.5*E22.0
ICD-10 Finland
Arthropathy associated with acromegaly
+∞
10.4
10
*
E22
ICD-10 Finland
Hyperfunction of pituitary gland
+∞
10.4
10
*
SPAT1254
SPAT
Administration of medicine
1.6
10.4
257
1685
E29.1
ICD-10 Finland
Testicular hypofunction
3.5
10.2
34
98
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.6
10.1
218
1381
YX8BD
NOMESCO Finland
Stereotactic extensive CT examination for dose design of radiotherapy
7.9
10.1
22
28
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.6
10.1
272
1819
L28
ICPC
Limited function/disability (L)
1.6
10.1
289
1960
R5140
NOMESCO Finland
Monitoring the use of the aid
1.7
10.1
204
1272
XCD10
NOMESCO Finland
Electrophysiological examination of eye
2.8
10.1
50
183
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.7
10.0
186
1134
D33.2
ICD-10 Finland
Benign neoplasm: Brain, unspecified
26.1
9.8
13
5
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.1
9.6
93
459
C08CA01
ATC
amlodipine; oral
1.4
9.4
623
4940
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.4
9.4
545
4228
XCH00
NOMESCO Finland
Eye pressure measurement
2.1
9.4
86
416
9350/1-C75.1
ICD-O-3
Craniopharyngioma, NOS, of pituitary gland
+∞
9.4
9
*
D352, E220,
ICD-10 Finland
+∞
9.4
9
*
UKC02
NOMESCO Finland
Cystoscopy
1.6
9.4
259
1741
A02BC01
ATC
omeprazole; systemic
1.4
9.3
473
3585
XA800
NOMESCO Finland
Neuropsychological investigation
2.1
9.2
85
413
I10
ICD-10 Finland
Essential (primary) hypertension
1.3
9.0
1017
8718
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
1.9
8.9
113
614
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
2.1
8.9
78
372
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.7
8.8
165
1008
N17
ICPC
Vertigo/dizziness
1.6
8.8
207
1341
A02BC05
ATC
esomeprazole; systemic
1.3
8.7
728
5971
WF002
NOMESCO Finland
Radical radiotherapy
2.0
8.7
94
485
XX9XW, ,
NOMESCO Finland
4.3
8.7
22
52
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.4
8.7
506
3924
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.3
8.6
669
5422
R20.2
ICD-10 Finland
Paraesthesia of skin
1.8
8.6
133
769
ZYC06
NOMESCO Finland
Real-time text-based remote transaction
9.0
8.5
17
19
UDH02
NOMESCO Finland
Rhinopharyngoscopy
1.8
8.5
129
743
R93.0
ICD-10 Finland
Abnormal findings on diagnostic imaging of skull and head, not elsewhere classified
12.8
8.4
14
11
XCK10
NOMESCO Finland
Photography of fundus of eye
1.7
8.4
163
1006
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.7
8.4
164
1014
R01AD09
ATC
mometasone; nasal
1.3
8.4
861
7261
2549, ,
FHL
+∞
8.3
8
*
25300
ICD-8 Finland
Diseases of pituitary gland, Aeromegalia
+∞
8.3
8
*
2550C
ICD-9 Finland
Disorders of adrenal glands, Cushing's syndrome[SYNDROMA CUSHING E HYPERSECRETIO HYPOFYSEOS]
+∞
8.3
8
*
E2300, D352,
ICD-10 Finland
+∞
8.3
8
*
25310
ICD-8 Finland
Diseases of pituitary gland, Panhypopituitarismus
+∞
8.3
8
*
BCA41
NOMESCO Finland
Endoscopic bilateral adrenalectomy
+∞
8.3
8
*
H01AX01
ATC
pegvisomant; parenteral
+∞
8.3
8
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
2.6
8.3
47
185
E22.2
ICD-10 Finland
Syndrome of inappropriate secretion of antidiuretic hormone
14.5
8.2
13
9
R04
ICPC
Breathing problem other
2.2
8.2
70
331
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.0
8.1
83
419
SPAT1301
SPAT
No procedures
1.4
8.1
539
4259
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
2.7
8.1
41
152
N06AX21
ATC
duloxetine; oral
1.6
8.1
218
1456
R06.0
ICD-10 Finland
Dyspnoea
1.4
8.0
459
3540
D43.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Central nervous system, unspecified
10.1
8.0
15
15
D33.9
ICD-10 Finland
Benign neoplasm: Central nervous system, unspecified
22.1
8.0
11
5
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
2.3
7.9
55
238
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.0
7.7
84
434
SPAT1240
SPAT
Therapeutic discussion
1.6
7.7
201
1332
AA4WT
NOMESCO Finland
Selective blood sample from sinus petrosus inferior
45.1
7.7
9
*
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
3.9
7.7
22
57
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
3.9
7.7
22
57
N91.4
ICD-10 Finland
Secondary oligomenorrhoea
5.9
7.7
20
34
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
2.9
7.6
35
123
SPAT1153
SPAT
Removal of sutures
1.3
7.6
541
4312
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.5
7.6
219
1484
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
2.2
7.6
61
281
XLA10, ,
NOMESCO Finland
2.0
7.6
84
437
2397A
ICD-9 Finland
Neoplasm of unspecified nature, Endocrine glands and other parts of nervous system
25.1
7.6
10
*
R01AD08
ATC
fluticasone; nasal
1.3
7.5
526
4181
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.5
7.5
241
1672
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.5
7.5
262
1849
M03AX01
ATC
botulinum toxin; parenteral
3.1
7.4
30
98
E24
ICD-10 Finland
Cushing syndrome
80.4
7.4
8
*
D35.6
ICD-10 Finland
Benign neoplasm: Aortic body and other paraganglia
80.4
7.4
8
*
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.5
7.4
262
1853
G93.0
ICD-10 Finland
Cerebral cysts
6.5
7.4
18
28
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.3
7.4
1028
8973
C09CA06
ATC
candesartan; oral
1.4
7.4
406
3109
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
1.7
7.4
119
698
N03AX14
ATC
levetiracetam; systemic
2.3
7.4
52
227
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.5
7.4
234
1620
J01MA02
ATC
ciprofloxacin; systemic
1.3
7.4
668
5512
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
1.8
7.3
112
647
E22.88
ICD-10 Finland
Other hyperfunction of pituitary gland
+∞
7.3
7
*
AAE05
NOMESCO Finland
Nasoendoscopic closure of cerebrospinal fluid fistula
+∞
7.3
7
*
E24.1
ICD-10 Finland
Nelson syndrome
+∞
7.3
7
*
23990
ICD-8 Finland
Neoplasm of unspecified nature of other and unspecified organs, Glandulae pituitariae et ductus craniopharyngice
+∞
7.3
7
*
D44.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Craniopharyngeal duct
+∞
7.3
7
*
SPAT1263
SPAT
Sampling
1.3
7.3
747
6264
N03AX09
ATC
lamotrigine; oral
1.9
7.2
93
509
C10AA07
ATC
rosuvastatin; oral
1.3
7.2
517
4126
EP1AE
NOMESCO Finland
Neck ultrasound examination
1.8
7.2
103
584
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.5
7.1
233
1624
S10
ICPC
Boil/carbuncle
1.8
7.1
107
616
PA2CC
NOMESCO Finland
Cerebral very extensive angiography with X-ray
4.1
7.1
19
47
R41.3
ICD-10 Finland
Other amnesia
2.3
7.0
50
219
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.5
7.0
240
1686
G43.9
ICD-10 Finland
Migraine, unspecified
1.7
7.0
116
686
Z2445
NOMESCO Finland
Psychologist
2.0
6.9
77
402
183
Kela drug reimbursment
Lamotrigin and topiramate
3.7
6.9
21
57
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.3
6.9
809
6890
H81.3
ICD-10 Finland
Other peripheral vertigo
2.3
6.8
49
216
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
2.4
6.8
44
185
DFF00
NOMESCO Finland
Pure tone audiometry
1.6
6.8
166
1085
D32.9
ICD-10 Finland
Benign neoplasm: Meninges, unspecified
6.1
6.8
17
28
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.3
6.8
525
4230
104
Kela drug reimbursment
Thyroid insufficiency
1.7
6.8
116
693
D35.59
ICD-10 Finland
Other paragangliom
40.2
6.8
8
*
186
Kela drug reimbursment
Growth retardation associated with renal failure (growth hormone)
40.2
6.8
8
*
BCA30
NOMESCO Finland
Unilateral adrenalectomy
16.7
6.7
10
6
E23.02
ICD-10 Finland
Neurosecretory dysfunction of the growth hormone
16.7
6.7
10
6
D06
ICPC
Abdominal pain localized other
1.6
6.7
150
959
OAB72
NOMESCO Finland
Weight control and weight loss guidance
3.5
6.7
22
63
M79.6
ICD-10 Finland
Pain in limb
1.3
6.7
747
6315
N03AX11
ATC
topiramate; oral
2.3
6.7
50
224
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.3
6.7
481
3835
R01AD58
ATC
fluticasone, combinations; nasal
1.3
6.7
449
3544
SPAT1296
SPAT
Other function in accordance with occupational therapy nomenclature
3.6
6.6
21
59
ZXE00
NOMESCO Finland
One hour or less
1.3
6.6
691
5795
Y99
ICPC
Genital disease male other
8.7
6.5
13
15
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
2.6
6.5
37
146
PA3AC
NOMESCO Finland
Carotis angiography with X-ray
6.2
6.5
16
26
N64.3
ICD-10 Finland
Galactorrhoea not associated with childbirth
5.3
6.5
18
34
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.5
6.4
170
1131
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.3
6.4
447
3542
R60.0
ICD-10 Finland
Localized oedema
1.5
6.4
191
1304
UJF30
NOMESCO Finland
Ileoscopy through colon
1.5
6.4
172
1149
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.5
6.3
205
1424
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.3
6.3
974
8549
AA4CD
NOMESCO Finland
Very extensive CT of sella turcica
+∞
6.3
6
*
C75.1
ICD-10 Finland
Malignant neoplasm: Pituitary gland
+∞
6.3
6
*
E23.3
ICD-10 Finland
Hypothalamic dysfunction, not elsewhere classified
+∞
6.3
6
*
E220, D352,
ICD-10 Finland
+∞
6.3
6
*
E22.80
ICD-10 Finland
Central precocious puberty
+∞
6.3
6
*
8240/3-C25.9
ICD-O-3
Neuroendocrine tumor, NOS, of pancreas, NOS
26.8
6.2
8
*
2250A
ICD-9 Finland
Benign neoplasm of brain and other parts of nervous system, Brain
26.8
6.2
8
*
A04
ICPC
Weakness/tiredness general
1.4
6.2
248
1794
S06.0
ICD-10 Finland
Concussion
1.5
6.2
182
1241
H93.1
ICD-10 Finland
Tinnitus
1.7
6.1
115
704
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
5.7
6.1
16
28
N97.0
ICD-10 Finland
Female infertility associated with anovulation
2.5
6.1
36
145
C08CA13
ATC
lercanidipine; oral
1.5
6.1
218
1545
YX8AD
NOMESCO Finland
Stereotactic CT examination for dose design of radiotherapy
12.6
6.1
10
8
D32.03
ICD-10 Finland
Benign meningioma in ventricles
12.6
6.1
10
8
ZZC00
NOMESCO Finland
Graft of fascia
12.6
6.1
10
8
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.3
6.0
375
2920
PA2AD
NOMESCO Finland
CT angiography of brain
3.6
6.0
19
53
BC1AD
NOMESCO Finland
CT of adrenal glands
3.3
6.0
22
68

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
249
45
62.71
307.65
1.9
1.5
—
—
—
0
0
643
539
16.81
307.65
2.0
1.4
7.01
9.66
u/l
3.67
530
440
1209
713
39.05
307.65
4.5
1.4
417.82
294.86
mu/l
2.69
1185
647
1498
1585
31.13
307.65
5.4
2.0
351.15
374.93
nmol/l
2.62
1456
1451
1069
112
195.11
307.65
3.0
1.6
17.09
20.35
nmol/l
2.80
1056
103
724
1285
8.10
307.65
5.1
2.2
12.26
12.80
nmol/l
0.87
697
1157
221
22
112.27
307.65
2.2
1.2
—
—
—
0
0
428
183
29.18
307.65
2.4
1.4
—
—
—
0
0
378
224
20.40
307.65
4.1
1.3
—
—
—
0
0
499
929
6.75
268.38
1.8
1.4
18.97
26.22
iu/l
4.78
407
780
329
532
7.16
200.12
2.8
1.8
40.73
39.91
nmol/l
0.16
324
510
149
77
20.77
193.81
2.6
1.6
3.11
4.72
nmol/l
0.26
126
62
276
382
8.18
192.82
3.0
1.9
170.27
207.83
pmol/l
4.22
262
360
237
293
9.00
181.53
1.9
1.5
0.31
0.37
nmol/l
0.71
169
238
435
1083
4.81
164.50
3.1
3.4
4.34
4.53
pmol/l
2.82
409
960
177
181
10.59
156.03
2.2
1.4
285.69
280.83
mosm/kgh2o
1.35
164
135
1908
13374
6.11
140.28
7.6
4.0
14.85
14.67
pmol/l
2.37
1862
12284
1221
7273
2.64
100.25
6.7
6.0
1.21
1.21
mmol/l
0.00
1143
6646
86
56
15.98
99.54
3.2
1.3
169.74
80.92
nmol/24h
4.42
86
56
1302
8039
2.65
98.61
7.4
6.7
1.21
1.21
mmol/l
0.06
1106
6866
867
4749
2.41
79.92
4.3
4.0
7.40
7.40
ph
0.03
189
911
374
1431
2.97
70.65
1.3
1.4
—
—
—
0
0
1393
9750
2.30
67.48
5.8
4.8
6.45
6.65
mmol/l
3.73
1334
9081
418
1799
2.66
62.52
6.6
8.3
5.10
5.09
kpa
0.08
398
1714
418
1800
2.65
62.44
6.6
8.3
15.25
12.31
kpa
13.91
397
1718
417
1794
2.66
62.41
6.6
8.3
0.81
1.06
mmol/l
0.85
299
1401
1925
15932
3.76
61.89
7.2
4.7
1.53
2.02
mu/l
5.19
1819
14740
129
279
4.86
56.09
2.2
1.4
16.42
23.91
u/l
2.20
120
230
124
272
4.78
52.98
1.7
1.3
82.29
63.76
mmol/l
2.98
111
223
100
204
5.10
46.50
2.1
1.4
49.41
40.60
mu/l
0.39
93
181
1985
17503
3.88
42.22
21.6
15.0
139.93
139.63
mmol/l
6.86
1972
17065
1986
17561
3.84
41.12
21.5
15.1
3.91
3.96
mmol/l
14.00
1969
17098
1006
6972
1.86
40.92
2.7
2.2
76.57
76.00
nmol/l
0.27
929
6305
134
391
3.59
38.90
1.5
1.5
1375.48
1155.51
e6/l
0.11
109
320
134
391
3.59
38.90
1.5
1.5
154.29
34.15
e6/l
0.63
105
308
129
367
3.68
38.89
1.5
1.5
—
—
—
0
0
551
3258
1.94
35.71
2.9
2.8
513.58
543.62
mosm/kgh2o
2.45
486
2808
86
201
4.42
33.91
1.6
1.3
—
—
nmol/l
—
0
0
77
174
4.56
31.68
1.7
1.6
—
—
—
0
0
973
7029
1.72
31.48
4.8
4.9
35.67
35.85
g/l
0.48
922
6569
726
4877
1.75
30.17
2.2
2.2
188.55
213.51
u/l
0.33
686
4601
73
165
4.55
30.02
1.8
1.8
—
—
—
0
0
653
4264
1.77
29.90
3.8
3.9
93.66
91.32
%
1.52
636
4149
77
183
4.33
29.73
1.7
1.5
—
—
—
0
0
83
210
4.07
29.51
1.6
1.3
—
—
—
0
0
77
193
4.10
27.73
1.5
1.4
1590.10
362.36
pmol/l
0.47
70
167
987
7336
1.66
27.35
12.7
13.8
1.23
1.22
inr
0.12
324
2192
127
447
2.96
27.07
1.3
1.3
530.36
507.43
mg/l
0.22
121
420
1549
13004
1.75
26.32
7.7
7.4
75.52
76.81
u/l
0.55
1472
12276
1506
12597
1.71
25.33
4.3
4.0
11.45
11.38
mm/h
0.06
1427
11697
114
393
3.01
25.21
1.2
1.3
3.43
3.80
mmol/l
4.58
103
368
417
2504
1.83
24.61
1.8
2.2
29.26
29.70
s
0.92
402
2424
1991
18333
2.97
24.56
20.6
15.2
77.22
75.87
umol/l
1.05
1991
18328
207
989
2.21
23.26
7.2
10.3
95.22
93.90
%
2.53
207
983
278
1495
1.99
22.84
8.5
9.1
126.55
122.32
g/l
3.14
266
1448
1907
17315
2.21
22.62
15.8
13.4
20.29
22.98
mg/l
3.86
1598
13602
206
994
2.19
22.58
7.2
10.1
1.23
1.35
%
1.35
206
989
205
989
2.19
22.47
7.3
10.2
0.72
0.68
%
1.07
205
984
993
7639
1.57
22.19
11.0
9.2
0.00
0.00
e9/l
0.59
858
6264
290
1612
1.93
21.57
8.2
8.7
96.66
95.70
%
1.65
278
1553
1754
15555
1.81
21.22
6.0
5.4
38.89
39.34
mmol/mol
1.34
1672
14489
742
5404
1.58
20.60
2.6
2.4
—
—
—
0
0
244
1299
1.99
20.54
3.7
3.8
1.23
1.23
mmol/l
0.02
221
1127
905
6908
1.55
20.33
2.2
2.1
—
—
—
0
0
1031
8121
1.53
19.91
6.1
6.3
—
—
—
0
0
999
7827
1.53
19.70
3.0
2.8
112.52
114.71
ug/l
0.15
933
7282
349
2130
1.77
19.08
5.4
5.9
1.00
1.04
mmol/l
2.03
340
1968
1825
16548
1.83
18.25
4.9
4.3
5.73
5.88
mmol/l
6.76
1729
15164
1953
18158
2.22
17.59
16.9
12.5
—
—
—
0
0
1075
8686
1.49
17.47
5.7
6.2
10.34
11.29
umol/l
3.35
1018
8237
85
308
2.83
17.22
2.0
1.9
4.90
5.16
mmol/24h
0.29
78
273
1199
9944
1.49
16.84
8.1
8.9
4.08
4.09
e9/l
0.02
1076
8716
236
1334
1.87
16.49
7.9
9.0
—
—
—
0
0
343
2171
1.69
16.27
2.3
2.5
22.63
23.35
%
0.43
304
1862
1373
11767
1.49
15.88
3.8
3.6
—
—
—
0
0
587
4252
1.53
15.81
2.2
2.1
2.93
2.92
mg/l
0.03
515
3620
362
2343
1.66
15.74
2.3
2.4
2.33
2.35
g/l
0.30
334
2178
1058
8637
1.46
15.60
5.6
5.8
0.04
0.04
e9/l
0.31
943
7523
1002
8108
1.45
15.40
6.0
5.9
2.94
2.81
%
0.94
954
7606
1684
15113
1.60
15.39
20.2
15.9
14.71
14.71
%
0.00
1668
14850
1087
8934
1.45
15.37
5.7
6.0
0.19
0.19
e9/l
0.57
983
7897
1007
8159
1.45
15.36
6.3
6.2
8.36
8.48
%
0.56
958
7665
1052
8627
1.44
14.85
5.6
5.8
0.57
0.57
e9/l
0.20
940
7518
394
2640
1.61
14.83
3.5
3.5
0.83
0.82
mmol/l
0.62
377
2487
971
7848
1.44
14.81
6.1
6.0
0.68
0.67
%
0.21
922
7348
842
6632
1.45
14.71
2.0
1.9
95.75
96.08
pmol/l
0.07
454
3521
778
6075
1.45
14.05
3.5
3.5
28.88
45.83
ng/l
1.45
513
3960
588
4350
1.49
14.02
4.3
4.3
—
—
—
0
0
1073
8891
1.43
13.96
5.6
5.8
1.94
1.96
e9/l
0.15
979
7924
607
4523
1.48
13.95
3.2
3.0
0.33
0.43
e6/l
0.54
475
3439
563
4143
1.49
13.74
2.7
2.3
—
—
—
0
0
652
4946
1.46
13.62
3.3
3.2
108.02
71.61
e6/l
0.58
513
3804
378
2564
1.58
13.39
2.3
2.4
12.93
13.56
umol/l
0.98
358
2393
593
4444
1.47
13.09
3.2
3.0
—
—
—
0
0
1294
11168
1.42
12.90
4.7
4.3
2618.76
1948.11
e6/l
0.13
17
153
1015
8406
1.40
12.81
6.2
6.0
29.05
28.20
%
1.67
969
7922
980
8122
1.39
12.03
2.9
2.6
—
—
—
0
0
996
8288
1.39
11.88
5.8
5.8
56.22
57.06
%
1.44
952
7807
31
76
4.13
11.60
1.2
1.4
146.00
168.31
mmol/24h
0.85
31
76
585
4457
1.43
11.58
1.7
1.6
1.49
1.38
mmol/l
2.17
518
3774
2022
19389
2.49
11.57
25.9
19.5
254.61
252.90
e9/l
0.56
1997
18916
2021
19381
2.46
11.45
25.9
19.6
40.65
40.30
%
2.29
1950
18254
667
5215
1.41
11.38
2.6
2.6
60.62
73.82
u/l
0.39
608
4833
471
3456
1.47
11.35
2.6
2.5
5.60
5.98
e6/l
0.28
429
3109
2022
19402
2.46
11.31
25.8
19.5
90.50
90.75
fl
1.88
2012
19145
2022
19403
2.46
11.29
25.7
19.4
30.11
30.26
pg
3.84
2012
19143
2022
19404
2.46
11.28
25.8
19.5
6.80
6.74
e9/l
0.30
1993
18891
738
5879
1.40
11.27
3.7
3.6
79.57
88.82
e6/l
0.19
538
4109
2022
19405
2.46
11.26
25.9
19.5
4.54
4.52
e12/l
1.06
1993
18895
530
3988
1.44
11.16
1.4
1.3
1.59
1.61
u/ml
0.01
143
1077
2022
19413
2.44
11.10
26.1
19.6
135.82
135.94
g/l
0.14
2010
19156
195
1180
1.72
10.75
4.3
3.9
79.23
86.57
ng/l
0.65
172
1038
233
1483
1.64
10.62
4.2
3.7
—
—
—
0
0
70
295
2.42
10.58
2.1
3.1
—
—
—
0
0
225
1422
1.65
10.54
7.3
7.6
1.26
1.35
mmol/l
0.67
216
1384
697
5549
1.38
10.51
3.3
3.4
2.35
2.35
mmol/l
0.35
627
4909
77
344
2.29
10.21
3.2
3.9
—
—
—
0
0
78
353
2.26
10.04
3.4
4.7
2.25
2.54
mmol/l
0.43
51
235
202
1266
1.66
9.77
3.5
4.4
0.00
0.61
%
1.08
56
337
1758
16336
1.49
9.68
4.3
3.8
1.39
1.30
mmol/l
4.31
1642
15075
165
988
1.73
9.45
8.9
7.3
24.64
24.51
mmol/l
0.21
153
932
1324
11751
1.35
9.42
4.5
4.2
—
—
—
0
0
336
2395
1.48
9.21
1.4
1.3
538.75
502.59
titre
0.11
64
487
550
4288
1.38
9.18
2.6
3.0
1238.58
1199.53
ng/l
0.06
471
3603
88
434
2.07
9.16
3.3
4.3
7.42
7.42
ph
0.23
81
381
208
1337
1.62
9.09
3.6
4.3
0.08
0.12
%
0.50
64
406
201
1284
1.63
9.01
3.6
4.1
0.41
0.67
%
1.46
61
411
461
3499
1.41
9.00
1.5
1.4
2.28
2.37
g/l
0.48
291
2176
1839
17307
1.54
8.92
5.2
4.6
2.83
2.79
mmol/l
0.98
1733
16069
632
5062
1.36
8.85
5.2
4.7
1.77
2.34
ug/l
3.38
574
4544
1932
18402
1.69
8.82
11.4
9.9
28.61
26.47
u/l
1.56
1889
17797
168
1033
1.68
8.74
7.0
5.3
—
—
—
0
0
487
3748
1.39
8.73
1.5
1.5
20.40
20.55
nmol/l
0.08
437
3218
202
1304
1.61
8.68
2.7
2.7
10.35
10.70
g/l
0.56
178
1195
112
613
1.87
8.67
3.8
4.6
—
—
—
0
0
1814
17043
1.50
8.65
4.8
4.2
4.67
4.68
mmol/l
0.27
1710
15922
63
279
2.30
8.58
1.5
1.7
0.78
0.85
g/l
0.19
43
214
216
1422
1.58
8.54
6.0
7.9
7.93
9.25
mmol/l
2.65
210
1357
1804
16945
1.48
8.46
4.8
4.2
1.39
1.46
mmol/l
9.79
1699
15732
987
8484
1.31
8.33
3.6
3.5
0.00
0.01
estimate
0.10
257
1562
213
1408
1.57
8.28
3.5
4.3
0.74
0.97
%
0.47
67
476
974
8399
1.30
7.86
4.8
4.7
0.00
0.00
estimate
0.50
260
1622
973
8412
1.29
7.61
3.6
3.5
0.00
0.00
estimate
0.99
263
1702
16
20
8.05
7.59
1.6
1.2
—
—
—
0
0
211
1423
1.54
7.50
1.2
1.2
—
—
—
0
0
379
2867
1.39
7.41
1.8
1.7
1092.65
1183.60
nmol/l
1.26
300
2190
38
143
2.69
7.33
1.2
1.2
35.28
40.42
mg/l
0.54
32
112
33
116
2.87
7.22
1.7
1.5
—
—
—
0
0
552
4464
1.32
6.95
4.0
3.9
0.00
0.00
estimate
0.05
257
1572
400
3086
1.37
6.90
3.2
3.6
234.35
444.69
ng/l
0.65
277
2271
534
4305
1.32
6.86
6.5
6.6
—
—
—
0
0
574
4688
1.31
6.70
3.4
3.1
—
—
—
0
0
681
5700
1.29
6.58
3.1
3.2
35.68
31.31
u/l
0.59
653
5415
190
1291
1.52
6.53
1.2
1.2
150.67
154.82
iu/ml
0.04
75
497
260
1885
1.43
6.44
1.3
1.3
—
—
—
0
0
13
16
8.17
6.33
2.0
1.0
5.54
6.12
nmol/l
0.15
13
16
246
1777
1.44
6.22
2.1
2.7
1.70
1.79
%
0.66
218
1578
65
334
1.98
6.15
3.0
2.5
16.67
16.43
%
0.19
30
175
589
4881
1.29
6.06
3.3
2.9
—
—
—
0
0
164
1098
1.54
6.05
1.3
1.3
32.11
52.58
au/ml
—
7
64
184
1267
1.50
5.95
2.7
2.8
66.45
66.78
g/l
0.25
177
1164
186
1289
1.49
5.83
2.3
2.8
71.42
71.42
e9/l
0.00
137
983
155
1036
1.54
5.77
3.3
3.5
5.03
5.17
kpa
1.66
145
988
215
1540
1.44
5.69
2.4
2.3
0.22
0.22
g/l
0.03
203
1437
308
2347
1.37
5.69
1.2
1.2
—
—
—
0
0
175
1207
1.49
5.62
2.6
2.4
13.75
24.95
au/ml
—
8
101
132
858
1.57
5.56
11.0
11.5
—
—
—
0
0
152
1025
1.52
5.44
3.4
3.5
7.42
7.41
ph
0.63
17
135
332
2580
1.34
5.39
2.9
2.9
2.64
2.45
e6/l
0.14
175
1400
1292
11835
1.24
5.29
3.5
3.1
46.19
46.67
u/l
0.08
1222
11107
87
517
1.71
5.23
1.4
1.6
0.25
0.24
g/l
0.81
81
488
5
0
+∞
5.21
1.0
0.0
327.80
—
nmol/l
—
5
0
151
1027
1.51
5.20
1.7
1.8
1.30
1.39
g/l
0.24
141
947
372
2964
1.31
5.06
3.1
2.9
2.44
2.44
mmol/l
0.11
326
2603
374
2986
1.31
5.01
3.2
3.0
0.79
0.74
ug/l
0.22
260
1896
88
536
1.67
4.86
1.4
1.6
1.26
1.18
g/l
1.99
83
505
120
790
1.55
4.82
2.3
2.3
9851.58
4754.80
u/l
0.60
26
315
88
538
1.66
4.79
2.8
2.5
9.48
10.45
g/l
1.62
81
488
37
171
2.18
4.69
1.4
1.3
—
—
—
0
0
347
2767
1.30
4.67
2.7
2.7
1.15
0.98
e6/l
0.26
190
1578
106
685
1.58
4.63
1.3
1.2
0.21
1.22
u/ml
—
9
59
280
2172
1.33
4.59
1.9
2.4
96.73
125.01
ug/g
1.11
214
1727
29
122
2.40
4.57
1.0
1.1
1.79
2.74
nmol/l
—
9
22
150
1048
1.46
4.56
2.8
2.5
—
—
—
0
0
277
2153
1.33
4.48
1.4
1.3
—
—
—
0
0
77
464
1.68
4.45
2.0
1.9
2.71
4.85
iu/l
2.01
25
164
36
169
2.15
4.41
1.4
1.3
6.00
6.95
g/l
0.93
21
119
36
169
2.15
4.41
1.4
1.3
0.34
0.40
g/l
0.37
21
118
36
169
2.15
4.41
1.4
1.3
2.96
2.86
g/l
0.09
21
118
77
466
1.68
4.38
1.9
2.1
9.54
11.21
mg/l
1.43
72
434
549
4662
1.24
4.38
3.7
3.6
—
—
—
0
0
197
1457
1.39
4.38
4.1
3.6
5.83
5.86
kpa
0.19
192
1409
200
1488
1.38
4.29
4.3
3.6
—
7.38
—
0
9
767
6774
1.21
4.12
3.2
3.2
5.78
5.87
ph
0.34
51
547
211
1598
1.36
4.06
4.0
4.0
—
—
—
0
0
138
975
1.44
3.99
1.3
1.2
—
—
—
0
0
74
456
1.65
3.96
3.1
3.7
1.40
1.49
mg/l
0.56
67
420
464
3909
1.24
3.94
1.8
1.7
1.09
1.10
mg/l
0.02
348
2936
253
1981
1.32
3.89
1.8
1.7
—
—
—
0
0
192
1450
1.36
3.77
4.3
3.6
2.06
1.93
mmol/l
0.21
157
1207
12
29
4.16
3.70
1.5
1.1
—
—
—
0
0
184
1386
1.36
3.68
1.5
1.5
—
—
—
0
0
9
16
5.64
3.66
1.1
1.1
—
—
—
0
0
72
458
1.59
3.44
3.1
2.4
38.23
38.09
g/l
0.07
64
409
267
2156
1.27
3.26
1.8
1.6
—
—
—
0
0
208
1627
1.31
3.24
2.1
2.4
29.84
40.36
u/l
2.48
180
1375
95
652
1.48
3.24
3.1
3.8
24.82
24.84
mmol/l
0.02
83
610
106
745
1.45
3.20
3.3
3.7
—
—
—
0
0
95
654
1.47
3.19
9.7
6.0
1.52
1.62
%
0.56
85
605
13
41
3.18
3.05
1.5
2.3
19.79
15.59
umol/l
0.54
13
41
241
1938
1.28
3.05
2.5
2.8
6.06
8.16
umol/l
1.72
207
1696
158
1201
1.34
3.02
3.7
3.0
4.44
4.63
kpa
0.69
153
1159
73
484
1.53
2.96
2.7
3.2
—
—
—
0
0
499
4357
1.19
2.87
2.3
2.6
339.93
4867.00
umol/l
10.65
434
3840
92
649
1.44
2.77
10.1
6.0
0.80
0.89
%
1.30
82
602
23
113
2.05
2.62
1.1
1.0
—
—
—
0
0
47
290
1.64
2.61
3.7
2.7
—
—
—
0
0
28
148
1.90
2.61
1.7
1.5
40.30
31.90
%
0.56
23
90
57
369
1.56
2.60
1.2
1.2
19.00
44.18
u/ml
—
6
36
28
149
1.89
2.56
6.6
3.7
52.38
53.18
%
0.05
21
131
69
468
1.49
2.55
1.2
1.2
85.56
93.78
titre
—
9
37
36
208
1.74
2.54
1.2
1.3
—
40.20
—
0
10
283
2371
1.22
2.51
2.1
2.0
—
—
—
0
0
14
57
2.47
2.45
1.1
1.3
—
—
—
0
0
63
425
1.50
2.41
1.4
1.3
—
—
—
0
0
66
450
1.48
2.40
1.2
1.2
11.72
9.07
u/ml
—
8
74
397
3450
1.19
2.39
1.7
1.7
445.92
33482720.50
pmol/l
3.26
331
2909
55
361
1.54
2.39
1.3
1.2
—
—
—
0
0
65
444
1.48
2.35
1.2
1.2
2.28
2.51
u/ml
—
5
46
334
2864
1.20
2.34
1.3
1.3
4.14
11.24
u/ml
4.24
133
1151
91
664
1.39
2.31
1.9
2.1
20.84
21.32
s
0.53
74
585
104
777
1.36
2.29
1.0
1.1
—
—
—
0
0
40
246
1.64
2.28
5.4
3.8
1.04
1.27
%
0.24
34
224
69
481
1.45
2.26
1.4
1.5
261.26
288.01
ug/g
0.65
40
271
77
550
1.42
2.22
2.3
2.3
712.40
446.79
ug/l
0.41
71
513
72
508
1.43
2.22
1.1
1.1
6.01
4.45
u/ml
—
9
61
24
128
1.89
2.21
1.1
1.1
—
—
—
0
0
16
73
2.20
2.21
2.2
3.6
141.89
151.84
umol/l
—
9
43
108
817
1.34
2.20
2.3
2.3
—
—
—
0
0
31
180
1.73
2.19
7.6
4.0
—
—
—
0
0
8
24
3.34
2.18
1.6
2.3
—
3.33
—
0
10
75
539
1.41
2.11
6.9
9.2
—
—
—
0
0
564
5091
1.15
2.07
3.0
3.2
7.72
7.79
mmol/l
0.13
485
4332
17
82
2.08
2.07
1.1
1.2
—
—
—
0
0
0
55
0.00
2.06
0.0
1.1
—
—
—
0
0
97
730
1.34
2.06
3.2
3.3
24.72
25.27
mmol/l
1.02
90
700
54
366
1.49
2.06
1.4
1.4
—
—
—
0
0
21
110
1.92
2.05
1.0
1.0
—
—
—
0
0
90
672
1.35
2.02
1.1
1.1
—
—
—
0
0
23
127
1.82
1.94
1.7
1.4
109.22
164.92
pmol/l
1.54
23
127
345
3018
1.17
1.93
1.3
1.3
23.18
31.17
iu/ml
1.06
91
976
54
372
1.46
1.92
1.4
2.3
0.85
0.87
nmol/l
0.11
49
314
29
173
1.69
1.90
1.8
2.6
0.19
1.72
g/24h
3.88
11
94
7
22
3.19
1.88
7.9
10.3
5.76
6.40
mmol/l
—
7
22
47
317
1.49
1.86
1.6
1.7
—
—
—
0
0
29
175
1.67
1.83
1.0
1.1
—
—
—
0
0
50
344
1.46
1.81
2.7
3.5
3.97
4.23
e9/l
0.50
50
344
16
80
2.01
1.80
1.4
3.0
604.00
895.51
u/ml
0.69
16
80
7
23
3.05
1.80
1.0
1.6
81.16
116.83
ng/l
—
7
23
145
1178
1.25
1.77
2.3
2.9
6.81
5.49
e9/l
0.24
115
984
71
523
1.37
1.77
12.2
7.0
1.19
1.26
mmol/l
0.44
58
448
235
2008
1.19
1.74
4.6
4.3
31.02
31.97
%
0.67
186
1408
552
5033
1.13
1.72
1.5
1.5
—
—
—
0
0
428
3838
1.14
1.72
3.3
3.5
—
—
—
0
0
82
622
1.33
1.70
1.2
1.3
217.96
220.41
miu/ml
0.02
30
304
16
82
1.96
1.69
2.8
2.5
—
—
—
0
0
12
56
2.15
1.61
2.2
1.8
—
—
—
0
0
10
43
2.33
1.58
1.0
1.1
—
—
—
0
0
6
20
3.01
1.58
1.2
1.2
—
—
—
0
0
24
144
1.67
1.57
1.1
1.0
306.96
289.73
mg/l
0.48
24
128
50
355
1.42
1.57
2.9
3.9
56.34
57.81
%
0.39
50
355
10
44
2.28
1.55
3.0
1.5
—
—
—
0
0
43
300
1.44
1.49
1.1
1.1
—
—
—
0
0
33
218
1.52
1.49
2.2
2.2
—
—
—
0
0
9
38
2.37
1.45
1.0
1.1
—
—
—
0
0
117
955
1.24
1.42
4.4
3.0
132.59
129.77
g/l
0.71
111
927
41
287
1.44
1.41
1.7
1.4
—
—
—
0
0
162
1907
0.84
1.40
1.3
1.3
—
—
—
0
0
62
467
1.34
1.40
3.5
3.7
39.23
64.13
mg/l
1.00
49
375
28
183
1.54
1.34
1.4
1.3
—
—
—
0
0
48
350
1.38
1.33
2.7
2.3
129.82
130.53
g/l
0.07
34
267
0
40
0.00
1.32
0.0
1.1
—
8.73
—
0
32
18
106
1.70
1.29
1.0
1.0
0.30
0.89
u/ml
—
5
39
402
3661
1.12
1.27
2.0
1.9
—
—
—
0
0
502
4631
1.11
1.26
3.0
3.3
820.46
336.25
mg/l
0.86
330
3008
6
25
2.40
1.24
1.7
1.6
—
—
—
0
0
61
468
1.31
1.24
3.5
3.6
30.71
66.75
mg/l
0.70
49
377
18
108
1.67
1.22
1.1
1.0
—
—
—
0
0
46
339
1.36
1.22
1.3
1.4
101.10
119.70
u/ml
—
10
62
10
49
2.05
1.22
1.0
1.0
—
—
—
0
0
49
365
1.35
1.22
16.3
8.4
10.70
11.23
mmol/l
0.81
40
324
136
1149
1.20
1.21
1.2
1.3
—
—
—
0
0
49
366
1.35
1.20
16.3
8.4
106.45
105.41
mmol/l
0.83
40
325
47
350
1.35
1.18
3.5
3.8
—
—
—
0
0
8
152
0.52
1.14
1.8
1.5
—
—
—
0
0
97
1168
0.82
1.11
1.5
1.4
—
—
—
0
0
5
21
2.38
1.09
1.2
1.1
—
—
—
0
0
21
136
1.55
1.08
1.1
1.6
0.91
1.19
promille
0.47
15
108
331
3013
1.12
1.07
1.7
1.6
—
—
—
0
0
15
90
1.67
1.04
1.8
2.5
—
—
—
0
0
17
106
1.61
1.02
5.9
6.5
—
—
—
0
0
25
171
1.47
1.02
4.4
4.5
435.00
99.06
u/ml
—
6
50
73
591
1.24
1.02
2.9
2.5
—
—
—
0
0
86
709
1.22
1.01
1.5
1.9
1.45
1.49
g/l
0.14
75
615
14
83
1.69
1.01
2.0
2.8
—
—
—
0
0
40
301
1.34
0.97
1.1
1.1
—
—
—
0
0
75
615
1.23
0.95
2.5
2.0
2.84
1.71
ug/l
0.48
63
542
18
269
0.67
0.93
4.7
3.9
93.83
29.13
u/ml
0.40
18
263
75
618
1.22
0.91
1.3
1.2
—
—
—
0
0
19
126
1.51
0.91
1.7
1.4
—
—
—
0
0
91
765
1.20
0.91
2.0
1.8
—
—
—
0
0
78
647
1.21
0.89
1.5
1.7
—
—
—
0
0
65
530
1.23
0.88
2.1
3.1
—
—
—
0
0
13
79
1.65
0.88
1.4
1.9
—
—
—
0
0
16
103
1.56
0.87
3.4
3.7
—
—
—
0
0
6
30
2.00
0.87
1.0
1.0
0.01
0.15
u/ml
—
6
30
20
136
1.48
0.86
1.4
1.1
—
—
—
0
0
91
770
1.19
0.86
1.8
2.2
—
—
—
0
0
94
1102
0.85
0.85
2.8
2.8
—
—
—
0
0
151
1332
1.14
0.84
2.2
2.4
6.54
6.96
ug/l
0.11
126
1188
15
96
1.57
0.84
1.0
1.2
—
—
—
0
0
10
57
1.76
0.83
1.2
1.1
—
—
—
0
0
24
171
1.41
0.83
11.3
6.5
9.33
7.19
mmol/l
0.55
19
140
29
387
0.75
0.82
1.4
1.3
—
—
—
0
0
32
241
1.33
0.80
3.2
2.8
282.13
71.58
u/ml
0.34
32
236
0
24
0.00
0.79
0.0
6.8
—
0.33
—
0
24
91
777
1.18
0.79
1.8
2.2
—
—
—
0
0
0
26
0.00
0.78
0.0
6.3
—
—
—
0
0
29
382
0.76
0.76
3.6
4.3
—
—
—
0
0
91
780
1.17
0.76
1.8
2.2
—
—
—
0
0
89
763
1.17
0.75
1.8
2.1
—
—
—
0
0
5
24
2.09
0.74
1.4
3.5
—
—
—
0
0
9
54
1.67
0.74
1.8
2.3
—
—
—
0
0
5
25
2.00
0.72
1.4
1.7
—
—
—
0
0
224
2047
1.11
0.72
1.5
1.4
—
—
—
0
0
141
1255
1.13
0.72
2.8
2.8
125.41
188.09
ng/l
2.17
127
1132
195
1771
1.11
0.71
1.4
1.4
—
—
—
0
0
84
721
1.17
0.70
1.8
2.2
—
—
—
0
0
7
41
1.71
0.70
1.6
1.9
—
—
—
0
0
9
58
1.55
0.69
1.2
1.1
—
—
—
0
0
9
144
0.62
0.69
1.3
1.4
—
—
—
0
0
14
93
1.51
0.69
1.1
1.4
125.64
143.35
nmol/l
1.09
14
93
43
346
1.25
0.69
5.9
2.6
—
—
—
0
0
33
257
1.29
0.68
1.6
1.6
—
—
—
0
0
22
162
1.36
0.66
3.3
3.2
—
—
—
0
0
132
1178
1.13
0.66
1.4
1.4
—
—
—
0
0
45
367
1.23
0.65
1.2
1.3
147.37
263.01
u/ml
4.73
24
226
22
163
1.35
0.64
2.0
2.2
—
—
—
0
0
5
29
1.73
0.64
1.0
1.1
—
1.98
pmol/l
—
0
5
45
369
1.22
0.63
1.5
1.3
—
—
—
0
0
26
199
1.31
0.62
1.3
1.2
—
—
—
0
0
21
279
0.75
0.61
3.2
3.1
0.82
0.85
nmol/l
0.09
15
220
5
30
1.67
0.61
1.0
1.4
—
189.00
—
0
6
71
610
1.17
0.61
1.9
2.2
—
—
—
0
0
189
2061
0.91
0.61
1.6
1.7
—
—
—
0
0
12
175
0.68
0.60
2.8
2.7
—
—
—
0
0
43
353
1.22
0.60
2.0
3.0
—
—
—
0
0
37
455
0.81
0.60
1.5
1.5
—
—
—
0
0
0
21
0.00
0.60
0.0
1.4
—
8.42
—
0
12
0
22
0.00
0.59
0.0
1.6
—
7.26
—
0
8
669
6435
1.06
0.59
3.0
2.7
—
—
—
0
0
13
89
1.46
0.58
2.8
2.9
7.41
7.42
ph
—
5
29
11
73
1.51
0.56
1.2
1.2
—
—
—
0
0
6
37
1.62
0.55
1.2
1.3
—
—
—
0
0
13
90
1.45
0.55
1.2
1.2
—
—
—
0
0
9
60
1.50
0.54
1.0
1.0
—
—
—
0
0
69
600
1.16
0.53
2.4
3.2
0.18
0.26
g/l
0.73
30
244
510
4886
1.06
0.52
3.6
3.9
8.58
9.24
mg/mmol
0.10
318
3127
17
126
1.35
0.51
1.9
1.4
88.53
78.91
umol/l
0.53
17
126
36
297
1.22
0.50
1.9
1.6
—
—
—
0
0
37
443
0.83
0.49
1.4
1.4
—
—
—
0
0
18
136
1.33
0.49
1.6
1.5
1.04
0.97
g/l
0.37
18
136
37
440
0.84
0.46
1.4
1.4
—
—
—
0
0
17
219
0.77
0.43
3.0
2.5
—
—
—
0
0
9
128
0.70
0.43
1.2
1.4
—
—
—
0
0
6
91
0.66
0.42
1.2
1.7
—
—
—
0
0
16
122
1.31
0.42
1.0
1.2
—
—
—
0
0
5
32
1.56
0.42
1.4
2.0
—
—
—
0
0
19
149
1.28
0.41
1.1
1.2
—
—
—
0
0
8
58
1.38
0.41
3.0
4.8
—
—
—
0
0
0
16
0.00
0.41
0.0
1.4
—
6.77
—
0
10
14
105
1.34
0.41
2.1
2.6
38215.86
40053.38
ug/l
0.20
14
105
40
342
1.17
0.41
1.0
1.1
5.00
6.42
u/ml
0.16
21
183
7
102
0.69
0.39
1.0
1.2
—
—
—
0
0
9
68
1.32
0.37
1.1
1.1
—
—
—
0
0
18
143
1.26
0.37
1.2
1.2
—
—
—
0
0
14
180
0.78
0.37
2.0
2.1
—
—
—
0
0
32
272
1.18
0.36
1.0
1.0
1.46
2.39
u/ml
0.72
18
126
28
235
1.19
0.36
1.1
1.2
—
—
—
0
0
9
71
1.27
0.36
1.2
1.2
—
0.04
—
0
5
34
291
1.17
0.35
1.5
1.2
14.00
5.19
u/ml
0.74
13
134
6
42
1.43
0.35
1.2
1.2
2.86
3.33
mmol/l
—
6
37
30
254
1.18
0.35
1.4
1.8
—
—
—
0
0
38
329
1.16
0.35
1.0
1.1
2.25
1.77
u/ml
0.10
17
139
30
256
1.17
0.33
1.0
1.1
2.32
4.30
u/ml
—
9
100
6
46
1.31
0.33
2.3
2.1
—
—
—
0
0
10
75
1.33
0.30
1.0
1.1
184.06
220.89
iu/ml
—
10
75
140
1317
1.07
0.29
3.3
3.3
—
—
—
0
0
34
298
1.14
0.28
1.1
1.1
10.08
1799.09
iu/ml
—
10
74
17
204
0.83
0.27
1.5
1.2
—
—
—
0
0
25
215
1.16
0.26
2.7
2.9
—
—
—
0
0
5
75
0.67
0.25
4.8
2.9
—
—
—
0
0
11
138
0.80
0.25
1.2
1.3
6.75
6.54
mmol/l
0.13
11
128
29
254
1.14
0.25
1.2
1.1
1.45
1.48
g/l
0.13
29
231
32
283
1.13
0.24
1.2
1.4
—
—
—
0
0
113
1065
1.06
0.24
1.6
1.6
—
—
—
0
0
24
276
0.87
0.24
1.3
1.2
—
—
—
0
0
74
796
0.93
0.24
2.9
3.3
—
—
—
0
0
14
115
1.22
0.23
1.2
1.3
1.53
1.56
g/l
0.19
14
115
7
92
0.76
0.22
1.3
1.4
16.95
34.09
nmol/l
—
7
74
10
124
0.81
0.21
8.4
14.5
858.10
834.80
nmol/l
—
10
119
0
11
0.00
0.21
0.0
3.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
13.40
—
0
12
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
12
98
1.23
0.21
1.0
1.7
0.57
4.32
u/field
—
7
77
11
134
0.82
0.20
1.0
1.1
—
—
—
0
0
94
888
1.06
0.20
2.9
3.0
348.92
52.49
u/ml
0.44
88
859
28
250
1.12
0.19
2.8
2.1
10.57
4.71
umol/l
0.61
23
176
43
394
1.09
0.19
2.0
1.7
16835.06
12458.47
e6/l
0.27
34
294
52
559
0.93
0.18
3.8
3.4
353.92
2624.58
u/ml
0.68
40
480
73
688
1.06
0.17
1.2
1.2
—
—
—
0
0
7
61
1.15
0.17
3.6
2.7
—
—
—
0
0
10
82
1.22
0.17
1.1
1.4
—
—
—
0
0
1509
14997
1.02
0.17
21.9
16.8
332.47
332.77
g/l
0.66
1499
14893
8
73
1.10
0.15
1.5
1.7
—
—
—
0
0
35
323
1.09
0.14
1.0
1.1
0.38
1.70
u/ml
3.08
14
160
29
265
1.10
0.14
1.7
1.4
—
—
—
0
0
7
87
0.80
0.14
1.0
1.1
—
—
—
0
0
10
85
1.18
0.12
1.2
1.4
—
—
—
0
0
30
278
1.08
0.12
1.0
1.1
1.00
3.08
u/ml
—
10
131
197
2016
0.97
0.11
1.7
1.7
—
—
—
0
0
47
445
1.06
0.11
2.5
2.3
—
—
—
0
0
30
321
0.93
0.10
1.1
1.1
—
—
—
0
0
16
177
0.90
0.10
1.3
1.1
—
—
—
0
0
30
320
0.94
0.09
1.1
1.1
—
—
—
0
0
5
46
1.09
0.09
1.4
1.2
35.16
37.14
g/l
—
5
25
37
391
0.95
0.09
2.5
2.3
179.77
123.37
ug/min
0.27
15
241
14
126
1.11
0.09
1.1
1.0
—
—
—
0
0
5
61
0.82
0.08
2.8
3.1
—
104.39
—
0
13
5
62
0.81
0.08
2.0
1.6
—
—
—
0
0
5
63
0.79
0.08
1.0
1.0
—
—
—
0
0
6
70
0.86
0.07
1.0
1.7
—
—
—
0
0
31
327
0.95
0.07
1.7
1.6
—
—
—
0
0
10
112
0.89
0.07
15.3
11.9
0.64
0.64
mmol/l
—
10
103
13
118
1.10
0.07
4.4
2.0
—
—
—
0
0
11
99
1.11
0.06
1.6
2.1
2.27
1.92
ug/l
—
6
86
14
129
1.09
0.05
1.1
2.2
6.08
6.63
mmol/l
—
9
91
18
169
1.07
0.05
1.0
1.1
—
—
—
0
0
18
169
1.07
0.05
1.1
1.1
—
—
—
0
0
156
1539
1.01
0.05
3.7
4.1
94.40
24.32
ug/l
0.58
118
1245
12
130
0.92
0.04
2.1
2.2
617.00
633.90
ml
—
6
81
14
150
0.93
0.04
1.1
1.3
—
—
—
0
0
45
461
0.98
0.03
1.1
1.1
—
—
—
0
0
26
251
1.04
0.02
2.2
2.9
—
—
—
0
0
14
132
1.06
0.02
2.4
1.9
12.16
11.08
%
0.47
14
132
36
351
1.03
0.02
3.1
3.6
24.50
24.77
mg/l
0.02
20
223
14
133
1.05
0.01
1.2
2.1
0.88
2.12
u/field
—
8
67
16
153
1.05
0.01
1.1
1.2
0.17
0.84
u/ml
—
9
82
53
523
1.01
0.01
1.2
1.2
—
—
—
0
0
195
1958
1.00
0.01
1.4
1.4
—
—
—
0
0
28
281
1.00
0.00
1.1
1.2
—
—
—
0
0
49
489
1.00
0.00
1.2
1.2
—
—
—
0
0
18
176
1.02
0.00
2.0
2.7
—
—
—
0
0
31
312
0.99
0.00
1.1
1.2
—
—
—
0
0
363
3628
1.00
0.00
3.7
3.9
1.01
1.02
kg/l
1.27
48
502
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
8
79
1.01
-0.00
1.1
1.2
—
—
—
0
0
38
380
1.00
-0.00
1.1
1.1
1.22
3.03
u/ml
1.31
17
193
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
1296.71
—
0
7
7
78
0.90
-0.00
1.6
2.2
15.91
126.78
ug/l
—
7
65
5
56
0.89
-0.00
1.8
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
7
77
0.91
-0.00
39.9
31.3
7.23
7.51
ug/l
—
7
69
6
68
0.88
-0.00
2.2
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
10
100
1.00
-0.00
1.2
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
9.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
84
0.95
-0.00
1.3
1.1
1180.63
1616.21
miu/ml
—
8
84
0
5
0.00
-0.00
0.0
1.6
—
2.72
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_PITUITARY_CRANIPHAR and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_PITUITARY_CRANIPHAR 1.615 [1.4, 1.86] < 0.001
Birth year 0.995 [0.99, 1.0] 0.242

During the follow-up period (1.1.1998 — 31.12.2019), 512 out of 4286 females with CD2_BENIGN_PITUITARY_CRANIPHAR died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_PITUITARY_CRANIPHAR 1.312 [1.15, 1.5] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 610 out of 3161 males with CD2_BENIGN_PITUITARY_CRANIPHAR died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_PITUITARY_CRANIPHAR.

N-year risk Females Males
1 0.146% 0.276%
5 0.905% 1.452%
10 2.203% 3.392%
15 4.48% 6.597%
20 7.905% 11.263%

Relationships between endpoints

Index endpoint: CD2_BENIGN_PITUITARY_CRANIPHAR – Benign neoplasm: Pituitary gland, craniopharyngeal duct

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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