No definition available.
Benign neoplasm: Pituitary gland, craniopharyngeal duct
DOID EFO Endpoint Browser PheWeb
CD2_BENIGN_PITUITARY_CRANIPHAR
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1958 |
4. Check minimum number of eventsNone |
1958 |
5. Include endpointsNone |
1958 |
6. Filter based on genotype QC (FinnGen only) |
1958 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Benign neoplasm: Pituitary gland, craniopharyngeal duct
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm: Pituitary gland, craniopharyngeal duct
- Benign neoplasm of other and unspecified endocrine glands
- Benign neoplasm of other and unspecified endocrine glands
- Benign neoplasms
- Benign neoplasms
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10221 | 5749 | 4361 |
| Only index persons | 9206 | 5345 | 3861 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.15 | 0.16 | 0.12 |
| Only index persons | 0.18 | 0.20 | 0.15 |
| Median age at first event (years) | |||
| Whole population | 50.74 | 47.54 | 55.24 |
| Only index persons | 49.72 | 46.32 | 54.42 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1958 | 1142 | 816 |
| Unadjusted period prevalence (%) | 0.38 | 0.39 | 0.36 |
| Median age at first event (years) | 50.74 | 46.87 | 56.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1736
- Matched controls
- 17358
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
343.2
323.0
699
34
H02AB09
ATC
hydrocortisone; systemic
68.7
323.0
605
134
N04BC06
ATC
cabergoline; oral (dopamine agonists)
253.3
323.0
329
16
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
+∞
323.0
1510
*
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
+∞
323.0
554
*
E22.1
ICD-10 Finland
Hyperprolactinaemia
166.2
323.0
388
30
E23.00
ICD-10 Finland
Panhypopituitarism
448.2
323.0
331
9
101
Kela drug reimbursment
Anterior pituitary hypofunction
203.3
323.0
330
20
D44.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pituitary gland
512.8
230.8
225
5
D35.31
ICD-10 Finland
Cyst in Rathke's pocket
+∞
213.0
200
*
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
461.2
170.8
168
*
ZXC86
NOMESCO Finland
Use of endoscopic device
79.8
153.9
173
24
H03AA01
ATC
levothyroxine sodium; systemic
4.4
153.6
728
2450
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
10.4
145.4
303
346
G02CB01
ATC
bromocriptine; systemic
27.4
144.8
202
83
E22.0
ICD-10 Finland
Acromegaly and pituitary gigantism
376.7
141.0
140
*
XCK00
NOMESCO Finland
Perimetry
8.0
133.6
328
491
AA4CM
NOMESCO Finland
Extensive MRI examination of sella turcica with 3 Tesla magnet
356.0
133.6
133
*
102
Kela drug reimbursment
Diabetes insipidus
220.4
120.3
123
6
H53.4
ICD-10 Finland
Visual field defects
17.9
113.2
181
112
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
17.5
105.5
170
107
2273A
ICD-9 Finland
Benign neoplasm of other endocrine glands and related structures, Pituitary gland and craniopharyngeal duct (pouch)
+∞
96.8
92
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.8
95.7
478
1560
E23.05
ICD-10 Finland
Lack of TSH
165.5
90.1
94
6
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
9.1
88.6
195
237
AA4DG
NOMESCO Finland
Very extensive MRI examination of sella turcica with high intensity magnet
310.8
87.6
88
*
G02CB03
ATC
cabergoline; oral (prolactine inhibitors)
44.2
84.0
104
25
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.9
80.8
294
699
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
9.6
79.6
170
195
D35.30
ICD-10 Finland
Craniopharyngoma
+∞
76.6
73
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
8.6
75.4
171
217
ZXC95
NOMESCO Finland
Use of surgical navigator
23.3
68.3
99
45
E23.2
ICD-10 Finland
Diabetes insipidus
121.5
65.3
70
6
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
24.7
61.2
87
37
2542
FHL
Transasal hypophysectomy
+∞
58.7
56
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.9
53.9
383
1541
H01AC01
ATC
somatropin; parenteral
96.4
51.1
56
6
E24.0
ICD-10 Finland
Pituitary-dependent Cushing disease
257.3
49.3
50
*
D35.0
ICD-10 Finland
Benign neoplasm: Adrenal gland
11.9
49.2
92
81
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.6
46.8
229
697
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
30.6
46.4
62
21
CS494
NOMESCO Finland
Other visual field testing
8.2
44.4
102
131
E89.30
ICD-10 Finland
Postprocedural hypopituitarism
+∞
43.9
42
*
301
Kela drug reimbursment
Growth hormone
215.0
41.0
42
*
22620
ICD-8 Finland
Benign neoplasm of endocrine glands, Pituitary gland and craniopharyngeal duct (pouch)
+∞
38.7
37
*
AA1AD
NOMESCO Finland
CT of head and brain
2.2
38.0
457
2389
E23.09
ICD-10 Finland
Pituitary insufficiency NOS
102.3
36.9
40
*
9350/1-C75.2
ICD-O-3
Craniopharyngioma, NOS, of craniopharyngeal duct
+∞
36.6
35
*
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
10.1
36.2
73
75
E23.03
ICD-10 Finland
Lack of ACTH
45.0
36.1
44
10
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
34.1
523
3014
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.9
33.6
226
857
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
12.6
33.4
60
49
H01CB03
ATC
lanreotide; parenteral
56.9
33.3
39
7
H01CB02
ATC
octreotide; parenteral
34.9
31.9
41
12
E23.6
ICD-10 Finland
Other disorders of pituitary gland
71.2
31.0
35
5
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
12.9
30.9
55
44
R51.80
ICD-10 Finland
Headache
2.3
30.6
316
1517
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.7
30.4
141
407
G02CB04
ATC
quinagolide; oral
108.6
29.7
32
*
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
11.3
29.6
56
51
E22.9
ICD-10 Finland
Hyperfunction of pituitary gland, unspecified
285.9
27.8
28
*
2370A
ICD-9 Finland
Neoplasm of uncertain behaviour of endocrine glands and nervous system, Pituitary gland and craniopharyngeal duct
285.9
27.8
28
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.6
27.8
228
966
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
8.8
27.3
59
69
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.8
26.6
188
732
E23
ICD-10 Finland
Hypofunction and other disorders of pituitary gland
+∞
26.1
25
*
E24.9
ICD-10 Finland
Cushing syndrome, unspecified
61.0
26.0
30
5
H47.2
ICD-10 Finland
Optic atrophy
17.8
25.8
40
23
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
4.2
25.3
98
241
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
5.9
24.6
70
123
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.4
23.7
227
1042
WX882
NOMESCO Finland
High dependency care
4.7
23.3
81
179
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
6.7
23.1
59
90
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
121.6
22.6
24
*
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
10.7
21.9
42
40
25320
ICD-8 Finland
Diseases of pituitary gland, Chromophobe adenoma, pituitary
+∞
20.9
20
*
E23.08
ICD-10 Finland
Hypopituitarism
212.4
20.6
21
*
AAK40
NOMESCO Finland
Closure of cerebrospinal fluid fistula
111.4
20.6
22
*
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
5.2
20.4
64
127
Y28
ICPC
Limited function/disability (Y)
20.3
20.4
30
15
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
15.5
19.8
32
21
UDM02
NOMESCO Finland
Sinoscopy
4.6
19.0
67
151
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.8
18.8
357
2154
E23.0
ICD-10 Finland
Hypopituitarism
+∞
18.8
18
*
N91.1
ICD-10 Finland
Secondary amenorrhoea
5.4
18.7
56
106
E23.7
ICD-10 Finland
Disorder of pituitary gland, unspecified
191.9
18.6
19
*
YX8VG
NOMESCO Finland
Stereotactic MRI exmaination with high intensity magnet for dose design of radiotherapy
30.4
18.3
24
8
R42
ICD-10 Finland
Dizziness and giddiness
1.8
18.0
355
2166
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
17.8
674
4949
2530A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Acromegaly and gigantism[ACROMEGALIA]
+∞
17.7
17
*
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
15.0
17.1
28
19
G47.3
ICD-10 Finland
Sleep apnoea
1.8
17.0
354
2191
D44.8
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pluriglandular involvement
64.0
16.8
19
*
T99
ICPC
Endocr/metab/nutrit disease other
5.3
16.7
51
99
WX402
NOMESCO Finland
General anaesthesia
1.9
16.4
279
1612
105
Kela drug reimbursment
Adrenal cortical hypofunction
18.7
16.0
24
13
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.6
15.8
114
449
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.3
15.7
153
705
TAB00
NOMESCO Finland
Lumbar puncture
2.9
15.6
96
342
AA4DM
NOMESCO Finland
Very extensive MRI examination of sella turcica with 3 Tesla magnet
+∞
15.6
15
*
N04BC01
ATC
bromocriptine; oral
85.9
15.6
17
*
TAA40
NOMESCO Finland
Cathetrisation of cerebrospinal fluid through skin
19.4
15.6
23
12
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
10.2
15.4
30
30
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
10.5
15.2
29
28
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
4.6
14.8
51
114
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.5
14.7
655
4934
H47.4
ICD-10 Finland
Disorders of optic chiasm
+∞
14.6
14
*
D352, E221
ICD-10 Finland
NA
+∞
14.6
14
*
D35.9
ICD-10 Finland
Benign neoplasm: Endocrine gland, unspecified
80.8
14.6
16
*
WX110
NOMESCO Finland
Local anesthesy
1.5
14.6
1144
9741
ZXA10
NOMESCO Finland
Bilateral
1.8
14.5
293
1792
D35.1
ICD-10 Finland
Benign neoplasm: Parathyroid gland
22.5
14.2
20
9
G44.2
ICD-10 Finland
Tension-type headache
1.9
13.8
232
1333
AA1BD
NOMESCO Finland
Extensive CT of head and brain
4.0
13.8
54
137
121
Kela drug reimbursment
Severe hypofunction of sexual glands
4.2
13.6
51
124
D35.3
ICD-10 Finland
Benign neoplasm: Craniopharyngeal duct
+∞
13.6
13
*
A02BC02
ATC
pantoprazole; systemic
1.5
13.3
1014
8494
2532A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Panhypopituitarism[PANHYPOPITUITARISMUS]
130.9
12.4
13
*
V04CD01
ATC
metyrapone; oral
130.9
12.4
13
*
J01DB01
ATC
cefalexin; oral
1.5
12.0
1347
12076
N75
ICPC
Benign neoplasm nervous system
47.0
11.9
14
*
2159
FHL
Other measure in this category
47.0
11.9
14
*
BCA31
NOMESCO Finland
Endoscopic unilateral adrenalectomy
16.5
11.7
18
11
H02AA02
ATC
fludrocortisone; oral
7.7
11.6
26
34
UJF32
NOMESCO Finland
Coloscopy
1.6
11.6
383
2662
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
11.5
427
3053
E89.39
ICD-10 Finland
Postprocedural hypopituitarism, other or several procedures
+∞
11.5
11
*
D44.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Adrenal gland
6.4
11.4
29
46
2531A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Other and unspecified anterior pituitary hyperfunction[HYPERPROLACTINAEMIA]
35.3
11.3
14
*
T73
ICPC
Neoplasm endocrine other/unspecified
35.3
11.3
14
*
-50
ICPC
Medication/prescr/renewal
2.6
11.3
79
308
N02BE01
ATC
paracetamol; systemic, rectal
1.5
11.1
1408
12805
E27.2
ICD-10 Finland
Addisonian crisis
25.2
11.1
15
6
YX8BD
NOMESCO Finland
Stereotactic extensive CT examination for dose design of radiotherapy
12.8
11.1
19
15
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
11.0
648
5094
G03DB01
ATC
dydrogesterone; oral
1.8
10.8
210
1262
D35.50
ICD-10 Finland
Carotid body
110.6
10.4
11
*
AA4BM
NOMESCO Finland
MRI examination of sella turcica with 3 Tesla magnet
+∞
10.4
10
*
AA4AD
NOMESCO Finland
CT of sella turcica
+∞
10.4
10
*
G96.0
ICD-10 Finland
Cerebrospinal fluid leak
16.1
10.3
16
10
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
4.1
10.1
38
94
ZYC05
NOMESCO Finland
Non-real-time text-based remote communication
6.5
10.0
25
39
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
10.0
260
1700
E89.6
ICD-10 Finland
Postprocedural adrenocortical(-medullary) hypofunction
55.3
9.6
11
*
R51
ICD-10 Finland
Headache
2.2
9.5
94
437
9530/0-C70.0
ICD-O-3
Meningioma, NOS, of cerebral meninges
6.6
9.4
23
35
2397A
ICD-9 Finland
Neoplasm of unspecified nature, Endocrine glands and other parts of nervous system
100.5
9.4
10
*
ZX050
NOMESCO Finland
Stereotactic radiotherapy
6.5
9.3
23
36
H53.1
ICD-10 Finland
Subjective visual disturbances
2.1
9.2
99
480
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.2
9.2
89
411
E66.8
ICD-10 Finland
Other obesity
2.2
9.1
91
425
H53.2
ICD-10 Finland
Diplopia
2.7
9.1
59
221
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.7
9.0
172
1028
D33.2
ICD-10 Finland
Benign neoplasm: Brain, unspecified
24.1
8.9
12
5
E24.8
ICD-10 Finland
Other Cushing syndrome
24.1
8.9
12
5
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.6
8.8
230
1504
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
1.9
8.7
119
637
D43.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, supratentorial
7.0
8.5
20
29
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.6
8.4
200
1276
D352, E220
ICD-10 Finland
NA
+∞
8.3
8
*
M14.5*E22.0
ICD-10 Finland
Arthropathy associated with acromegaly
+∞
8.3
8
*
2549
FHL
NA
+∞
8.3
8
*
2550C
ICD-9 Finland
Disorders of adrenal glands, Cushing's syndrome[SYNDROMA CUSHING E HYPERSECRETIO HYPOFYSEOS]
+∞
8.3
8
*
E2300, D352
ICD-10 Finland
NA
+∞
8.3
8
*
D35.6
ICD-10 Finland
Benign neoplasm: Aortic body and other paraganglia
+∞
8.3
8
*
AA4BD
NOMESCO Finland
Extensive CT of sella turcica
+∞
8.3
8
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.8
8.3
140
803
I10
ICD-10 Finland
Essential (primary) hypertension
1.3
8.3
786
6604
D43.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Central nervous system, unspecified
14.5
8.2
13
9
A55
ICPC
General and Unspecified, Local injection/infiltration
4.6
8.2
27
60
R55
ICD-10 Finland
Syncope and collapse
1.7
8.1
152
903
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.0
8.1
106
559
R53
ICD-10 Finland
Malaise and fatigue
1.5
8.0
297
2105
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
7.9
321
2316
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.5
7.9
257
1767
E21.0
ICD-10 Finland
Primary hyperparathyroidism
4.2
7.8
28
68
E03.89
ICD-10 Finland
Other specified hypothyroidism
2.5
7.8
57
230
UKC02
NOMESCO Finland
Cystoscopy
1.6
7.7
207
1360
D33.9
ICD-10 Finland
Benign neoplasm: Central nervous system, unspecified
45.2
7.7
9
*
R93.0
ICD-10 Finland
Abnormal findings on diagnostic imaging of skull and head, not elsewhere classified
15.1
7.7
12
8
YX8AD
NOMESCO Finland
Stereotactic CT examination for dose design of radiotherapy
25.1
7.6
10
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.4
7.5
424
3259
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.7
7.5
166
1035
S10
ICPC
Boil/carbuncle
2.1
7.5
82
403
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.4
7.5
405
3089
D32.03
ICD-10 Finland
Benign meningioma in ventricles
80.4
7.4
8
*
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.0
7.4
91
469
XCK10
NOMESCO Finland
Photography of fundus of eye
1.7
7.4
139
827
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
3.3
7.4
35
108
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.7
7.3
150
916
G93.0
ICD-10 Finland
Cerebral cysts
8.4
7.3
15
18
9350/1-C75.1
ICD-O-3
Craniopharyngioma, NOS, of pituitary gland
+∞
7.3
7
*
H01AX01
ATC
pegvisomant; parenteral
+∞
7.3
7
*
25300
ICD-8 Finland
Diseases of pituitary gland, Aeromegalia
+∞
7.3
7
*
E24.1
ICD-10 Finland
Nelson syndrome
+∞
7.3
7
*
SPAT1254
SPAT
Administration of medicine
1.6
7.3
202
1337
XLA10
NOMESCO Finland
NA
2.2
7.2
73
344
E22.2
ICD-10 Finland
Syndrome of inappropriate secretion of antidiuretic hormone
15.8
7.2
11
7
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
2.3
7.2
63
280
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.5
7.1
254
1783
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
6.0
7.1
18
30
BC1AD
NOMESCO Finland
CT of adrenal glands
6.0
7.1
18
30
A02BC01
ATC
omeprazole; systemic
1.4
7.0
392
2999
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
10.1
7.0
13
13
D32.9
ICD-10 Finland
Benign neoplasm: Meninges, unspecified
7.0
7.0
16
23
104
Kela drug reimbursment
Thyroid insufficiency
1.9
6.9
100
546
186
Kela drug reimbursment
Growth retardation associated with renal failure (growth hormone)
40.2
6.8
8
*
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
7.2
6.7
15
21
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
3.2
6.7
33
106
XA800
NOMESCO Finland
Neuropsychological investigation
2.1
6.7
69
331
ZX120
NOMESCO Finland
Intravenous
1.7
6.6
127
760
SPAT1240
SPAT
Therapeutic discussion
1.6
6.6
162
1038
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
3.0
6.6
35
118
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.6
6.5
187
1247
E29.1
ICD-10 Finland
Testicular hypofunction
4.4
6.5
22
51
J01MA02
ATC
ciprofloxacin; systemic
1.3
6.5
540
4399
E22
ICD-10 Finland
Hyperfunction of pituitary gland
70.1
6.4
7
*
2535A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Diabetes insipidus
70.1
6.4
7
*
2250A
ICD-9 Finland
Benign neoplasm of brain and other parts of nervous system, Brain
70.1
6.4
7
*
C08CA01
ATC
amlodipine; oral
1.3
6.4
455
3617
C08CA13
ATC
lercanidipine; oral
1.6
6.4
157
1006
XCD10
NOMESCO Finland
Electrophysiological examination of eye
2.6
6.4
42
161
BCA30
NOMESCO Finland
Unilateral adrenalectomy
14.4
6.4
10
7
XF400
NOMESCO Finland
ECG with 12 standard connections
1.5
6.4
210
1448
SPAT1263
SPAT
Sampling
1.3
6.4
638
5339
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
2.5
6.4
46
187
PA3AC
NOMESCO Finland
Carotis angiography with X-ray
8.2
6.3
13
16
XX1ZW
NOMESCO Finland
Very extensive written report from radiologist
8.2
6.3
13
16
TPH07
NOMESCO Finland
Cathetrisation of artery
1.7
6.3
129
787
SPAT1153
SPAT
Removal of sutures
1.3
6.3
443
3515
WF099
NOMESCO Finland
Other radiotherapy
5.5
6.3
17
31
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.7
6.3
122
737
E24
ICD-10 Finland
Cushing syndrome
+∞
6.3
6
*
E220, D352
ICD-10 Finland
NA
+∞
6.3
6
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
2.9
6.2
36
127
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
2.7
6.2
38
141
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.5
6.2
198
1358
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
3.3
6.2
29
90
XX3DW
NOMESCO Finland
Time consuming IT work
1.6
6.2
139
874
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.6
6.1
172
1142
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.7
6.1
122
741
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.4
6.1
329
2499
ZZC00
NOMESCO Finland
Graft of fascia
12.6
6.1
10
8
N06AX21
ATC
duloxetine; oral
1.6
6.0
149
961
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.4
6.0
318
2405
R20.2
ICD-10 Finland
Paraesthesia of skin
1.8
6.0
97
552
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
1143
669
39.64
307.65
4.6
1.4
381.6
299.9
mu/l
2.37
1119
605
1001
108
188.59
307.65
3.2
1.6
17.1
20.6
nmol/l
2.97
988
100
604
503
16.92
307.65
2.0
1.3
7.1
9.7
u/l
3.49
497
408
204
21
108.32
307.65
2.3
1.3
—
—
—
0
0
685
1213
8.15
307.65
5.3
2.2
12.4
12.8
nmol/l
0.55
659
1080
1418
1503
31.58
307.65
5.6
2.0
348.6
375.7
nmol/l
3.10
1376
1377
457
878
6.49
237.28
1.9
1.4
19.5
26.6
iu/l
4.17
371
736
178
99
19.68
224.54
1.4
1.7
—
—
—
0
0
303
495
7.06
182.37
2.9
1.7
41.5
39.5
nmol/l
0.47
298
477
137
72
20.38
176.82
2.5
1.6
2.9
4.9
nmol/l
0.32
114
58
254
362
7.91
172.82
3.0
1.8
172.9
207.9
pmol/l
3.46
241
343
220
278
8.79
165.48
1.9
1.5
0.3
0.4
nmol/l
0.43
158
223
416
1023
4.89
160.10
3.2
3.4
4.3
4.5
pmol/l
2.58
390
908
169
175
10.47
147.68
2.3
1.3
285.4
280.7
mosm/kgh2o
1.20
156
130
1789
12552
5.93
130.34
7.8
4.0
14.9
14.7
pmol/l
3.61
1746
11517
1155
6884
2.65
95.03
6.7
6.0
1.2
1.2
mmol/l
0.12
1081
6247
1228
7604
2.65
92.32
7.4
6.7
1.2
1.2
mmol/l
0.01
1040
6435
251
770
3.59
68.51
5.2
11.1
24.1
24.3
mmol/l
0.57
245
727
1317
9180
2.33
65.40
5.8
4.8
6.5
6.7
mmol/l
3.83
1261
8550
402
1687
2.74
63.69
6.3
8.4
5.1
5.1
kpa
0.05
382
1609
401
1681
2.74
63.66
6.3
8.4
0.8
1.1
mmol/l
1.28
283
1300
402
1688
2.74
63.61
6.3
8.4
15.3
12.3
kpa
14.31
381
1613
1804
14910
3.67
57.94
7.2
4.7
1.5
2.0
mu/l
5.19
1701
13777
119
267
4.68
49.49
2.2
1.4
16.1
24.2
u/l
2.50
110
222
380
1884
2.26
40.35
5.5
7.2
105.0
104.4
mmol/l
1.97
372
1843
129
366
3.70
39.10
1.5
1.5
1437.6
1222.5
e6/l
0.10
104
299
129
366
3.70
39.10
1.5
1.4
161.6
33.6
e6/l
0.65
100
288
1864
16464
3.75
38.67
21.9
15.1
140.0
139.6
mmol/l
7.56
1852
16046
1865
16517
3.72
37.70
21.8
15.2
3.9
4.0
mmol/l
13.19
1849
16078
939
6571
1.82
36.35
2.8
2.3
76.9
76.1
nmol/l
0.42
869
5942
72
155
4.78
31.44
1.8
1.7
—
—
—
0
0
687
4592
1.76
29.30
2.1
2.2
192.8
217.9
u/l
0.31
648
4342
46
72
6.52
28.22
2.0
1.9
—
—
—
0
0
912
6642
1.70
28.22
4.9
4.9
35.6
35.8
g/l
0.50
860
6198
1735
15254
2.21
27.59
16.4
12.1
84.6
84.1
ml/min/173m2
0.48
1559
12553
122
416
3.06
27.54
1.3
1.3
530.4
503.7
mg/l
0.26
116
390
110
367
3.12
25.77
1.2
1.3
3.4
3.8
mmol/l
3.78
99
343
1461
12250
1.76
25.28
7.7
7.4
75.4
77.1
u/l
0.79
1388
11532
70
179
4.02
24.56
1.5
1.4
321.2
315.9
pmol/l
0.04
55
134
392
2353
1.83
23.21
1.8
2.1
29.3
29.7
s
0.73
377
2279
1871
17230
2.93
22.95
20.8
15.3
77.5
76.0
umol/l
1.21
1871
17225
263
1402
2.01
22.22
8.1
9.2
126.4
122.0
g/l
3.15
248
1349
1407
11840
1.67
22.17
4.3
4.0
11.4
11.5
mm/h
0.06
1333
10990
194
928
2.21
21.78
6.6
10.4
95.2
93.9
%
2.28
194
922
192
927
2.19
21.04
6.7
10.3
0.7
0.7
%
1.29
192
922
193
934
2.18
21.03
6.6
10.2
1.2
1.3
%
1.56
193
929
1786
16254
2.12
20.06
15.9
13.4
20.4
23.1
mg/l
3.61
1501
12760
231
1238
1.98
19.11
3.7
3.6
1.2
1.2
mmol/l
0.02
210
1074
334
2025
1.78
18.79
5.5
6.0
1.0
1.0
mmol/l
2.10
324
1876
937
7344
1.53
18.45
3.1
2.8
110.5
115.7
ug/l
0.42
874
6836
1643
14650
1.76
18.29
6.1
5.4
38.9
39.4
mmol/mol
1.35
1565
13637
1014
8179
1.50
16.79
5.7
6.2
10.5
11.4
umol/l
2.84
956
7744
1711
15556
1.79
16.23
4.9
4.3
5.7
5.9
mmol/l
7.16
1624
14248
551
3988
1.53
14.95
2.2
2.2
2.9
2.9
mg/l
0.02
486
3398
1121
9364
1.46
14.67
8.2
8.9
4.1
4.1
e9/l
0.08
1005
8204
317
2042
1.66
14.02
2.3
2.5
22.8
23.3
%
0.29
278
1752
334
2204
1.62
13.38
2.3
2.4
2.3
2.3
g/l
0.21
307
2052
1530
13720
1.53
13.07
20.8
16.2
13.6
13.6
%
0.29
1511
13432
527
3877
1.49
12.91
2.7
2.3
—
—
—
0
0
366
2492
1.58
12.81
3.6
3.5
0.8
0.8
mmol/l
1.16
347
2337
615
4671
1.46
12.79
3.3
3.2
112.5
74.9
e6/l
0.56
486
3585
571
4282
1.47
12.66
3.3
3.1
0.3
0.4
e6/l
0.41
442
3224
785
6268
1.42
12.34
2.0
1.9
96.0
95.8
pmol/l
0.03
414
3333
924
7618
1.40
11.97
4.3
4.1
—
—
—
0
0
351
2405
1.56
11.88
2.3
2.5
12.9
13.5
umol/l
0.81
330
2227
725
5748
1.41
11.69
3.5
3.4
29.6
46.7
ng/l
1.34
481
3749
1214
10511
1.41
11.67
4.8
4.3
2618.8
1845.4
e6/l
0.15
17
139
631
4910
1.42
11.20
2.6
2.6
61.2
56.7
u/l
0.48
573
4544
444
3254
1.47
10.82
2.7
2.6
5.7
5.9
e6/l
0.13
394
2859
1898
18204
2.39
10.55
26.1
19.6
253.9
252.6
e9/l
0.36
1876
17760
49
174
2.86
10.41
1.1
1.1
—
—
—
0
0
214
1341
1.67
10.40
6.6
7.7
1.2
1.3
mmol/l
2.15
202
1288
1898
18217
2.37
10.30
26.1
19.6
4.5
4.5
e12/l
0.97
1873
17738
187
1134
1.72
10.27
4.5
3.9
75.5
87.1
ng/l
1.55
165
1000
1898
18221
2.36
10.22
26.1
19.6
6.8
6.7
e9/l
0.25
1874
17741
1898
18225
2.35
10.15
26.3
19.7
135.8
135.9
g/l
0.06
1887
17984
1657
15341
1.52
9.99
4.3
3.8
1.4
1.3
mmol/l
3.63
1550
14147
53
202
2.67
9.88
1.1
1.1
—
—
—
0
0
51
191
2.71
9.83
1.1
1.1
—
—
—
0
0
245
1620
1.59
9.57
3.4
3.1
—
—
—
0
0
157
927
1.75
9.48
9.2
7.4
24.6
24.5
mmol/l
0.19
141
862
541
4212
1.39
9.24
1.7
1.6
1.5
1.4
mmol/l
1.95
476
3557
209
1342
1.62
9.22
6.0
7.9
7.9
9.3
mmol/l
2.68
204
1285
652
5249
1.36
9.01
3.3
3.4
2.3
2.4
mmol/l
0.35
579
4614
487
3742
1.40
8.94
1.4
1.3
1.1
1.4
u/ml
0.43
131
1011
337
2430
1.47
8.75
1.9
1.8
—
—
—
0
0
1708
16018
1.52
8.61
4.8
4.2
4.7
4.7
mmol/l
0.25
1610
14933
1699
15925
1.51
8.49
4.7
4.2
1.4
1.5
mmol/l
8.70
1599
14753
1729
16269
1.54
8.45
5.2
4.6
2.8
2.8
mmol/l
0.96
1626
15073
189
1220
1.61
8.15
2.7
2.7
10.4
10.7
g/l
0.55
166
1117
516
4061
1.37
8.07
2.6
3.0
1262.2
1211.6
ng/l
0.07
445
3416
13
20
6.54
8.07
1.2
1.5
—
—
—
0
0
362
2700
1.42
7.78
1.8
1.7
1095.4
1187.1
nmol/l
1.24
288
2064
594
4801
1.34
7.76
5.3
4.7
1.7
2.4
ug/l
4.64
536
4313
930
8009
1.31
7.72
3.6
3.5
0.0
0.0
estimate
0.01
241
1476
1812
17295
1.64
7.62
11.4
10.0
28.5
26.5
u/l
1.31
1772
16728
918
7905
1.30
7.58
3.6
3.5
0.0
0.0
estimate
0.00
241
1500
384
2911
1.40
7.49
3.3
3.6
238.6
450.7
ng/l
0.61
265
2144
918
7923
1.30
7.38
4.8
4.7
0.0
0.0
estimate
0.50
244
1532
11
16
6.91
7.15
1.6
1.0
4.7
6.1
nmol/l
0.47
11
16
35
129
2.74
7.04
1.1
1.1
—
—
—
0
0
520
4213
1.32
6.49
4.0
3.9
0.0
0.0
estimate
0.04
241
1485
35
135
2.62
6.47
1.2
1.1
36.5
40.1
mg/l
0.31
29
105
104
614
1.73
6.35
2.0
1.8
—
—
—
0
0
96
557
1.76
6.23
1.8
1.7
—
—
—
0
0
234
1680
1.45
6.14
2.1
2.7
1.7
1.8
%
0.52
206
1496
62
314
2.01
6.12
3.0
2.5
16.6
16.5
%
0.11
29
164
446
3562
1.33
6.11
1.5
1.5
20.5
20.6
nmol/l
0.07
399
3056
178
1212
1.52
6.09
1.2
1.2
111.4
158.0
iu/ml
0.91
67
465
639
5367
1.28
5.99
3.1
3.2
35.9
31.4
u/l
0.56
612
5099
172
1196
1.48
5.33
2.6
2.8
66.4
66.8
g/l
0.36
165
1099
5
0
+∞
5.21
1.0
0.0
327.8
—
nmol/l
—
5
0
123
803
1.57
5.12
10.7
11.7
—
—
—
0
0
144
975
1.51
5.09
3.5
3.6
5.0
5.2
kpa
1.22
129
914
72
409
1.79
5.08
1.4
1.3
—
—
—
0
0
112
717
1.60
5.07
2.3
2.2
9851.6
4654.4
u/l
0.61
26
291
313
2440
1.34
5.00
3.0
2.9
2.7
2.4
e6/l
0.26
168
1328
110
706
1.59
4.93
1.8
2.0
38.4
39.4
u/l
0.17
102
630
707
6118
1.24
4.93
3.8
3.7
—
—
—
0
0
23
83
2.79
4.88
1.1
1.1
—
—
—
0
0
28
113
2.50
4.80
1.2
1.1
1.3
1.1
u/l
0.25
14
57
158
1106
1.47
4.76
1.6
1.7
—
—
—
0
0
75
440
1.73
4.76
2.0
1.9
2.2
5.0
iu/l
4.83
23
152
136
928
1.50
4.65
3.4
3.5
1.7
1.7
mmol/l
0.01
92
699
1208
11108
1.23
4.59
3.5
3.1
45.9
46.4
u/l
0.08
1144
10419
198
1457
1.40
4.55
2.4
2.3
0.2
0.2
g/l
0.01
186
1362
134
917
1.50
4.53
1.4
1.5
—
—
—
0
0
353
2843
1.29
4.44
3.2
2.9
0.8
0.7
ug/l
0.17
249
1805
82
505
1.65
4.38
2.9
2.5
9.5
10.6
g/l
2.22
69
432
224
1695
1.36
4.35
3.7
4.2
224.5
248.6
u/l
2.12
212
1614
86
539
1.62
4.29
2.8
2.5
—
—
—
0
0
86
539
1.62
4.29
2.8
2.5
3.8
3.8
g/l
0.05
64
398
86
539
1.62
4.29
2.8
2.5
7.1
7.3
g/l
0.54
65
416
79
485
1.66
4.27
1.5
1.6
0.2
0.2
g/l
0.47
74
458
12
31
3.89
4.25
1.1
1.2
—
—
—
0
0
1204
11118
1.22
4.18
3.4
3.2
—
—
—
0
0
325
2615
1.29
4.11
2.7
2.7
1.2
1.0
e6/l
0.27
180
1494
27
116
2.35
4.09
1.0
1.1
1.8
3.0
nmol/l
—
9
20
459
3856
1.25
4.06
4.3
4.1
22.3
21.3
%
0.78
207
1786
81
509
1.62
4.02
2.9
2.5
2.8
3.1
g/l
2.20
63
405
83
527
1.60
3.95
1.7
1.7
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
23
94
2.46
3.88
1.1
1.1
—
—
—
0
0
97
643
1.54
3.85
1.3
1.2
0.2
1.2
u/ml
—
9
55
184
1377
1.37
3.84
4.3
3.6
2.1
1.9
mmol/l
0.18
146
1110
58
338
1.74
3.83
4.0
3.1
8.5
8.1
kpa
0.88
52
313
13
39
3.35
3.76
1.5
2.3
19.8
15.8
umol/l
0.50
13
39
166
1227
1.39
3.74
2.7
2.6
73.1
68.6
ml/min/173m2
0.65
60
479
71
440
1.64
3.74
2.0
2.1
9.6
11.3
mg/l
1.33
66
409
342
2804
1.27
3.71
3.2
2.9
2.4
2.4
mmol/l
0.08
298
2465
10
25
4.02
3.70
1.0
1.0
—
—
—
0
0
92
613
1.53
3.58
10.0
6.0
1.5
1.6
%
0.49
82
569
70
441
1.61
3.48
3.1
3.7
1.4
1.5
mg/l
0.34
63
406
14
47
2.99
3.41
1.1
1.1
—
—
—
0
0
71
452
1.59
3.39
1.6
1.6
—
—
—
0
0
73
468
1.58
3.38
3.1
2.6
0.4
1.2
g/l
2.10
66
415
14
48
2.93
3.30
1.1
1.1
—
—
—
0
0
255
2049
1.28
3.26
1.8
2.4
96.3
123.9
ug/g
0.97
192
1621
427
3662
1.21
3.03
1.8
1.7
1.1
1.1
mg/l
0.04
322
2753
66
426
1.57
3.01
3.2
2.4
38.3
38.0
g/l
0.13
59
375
14
51
2.76
2.98
1.1
1.2
—
—
—
0
0
212
1686
1.29
2.95
1.7
1.8
—
—
—
0
0
8
17
4.72
2.92
1.0
1.1
—
—
—
0
0
14
52
2.70
2.89
1.1
1.2
—
—
—
0
0
37
207
1.80
2.87
1.3
1.4
—
—
—
0
0
212
1698
1.28
2.80
1.8
1.8
—
—
—
0
0
118
872
1.38
2.73
1.6
1.6
—
—
—
0
0
6
10
6.01
2.70
1.0
1.2
—
—
—
0
0
16
67
2.40
2.63
1.3
1.1
0.3
0.3
g/l
0.91
11
57
70
474
1.49
2.61
1.1
1.1
7.6
4.6
u/ml
—
7
59
87
615
1.43
2.61
3.2
3.8
24.7
24.8
mmol/l
0.14
75
577
224
1825
1.26
2.58
2.6
2.8
6.2
8.3
umol/l
1.51
194
1596
467
4095
1.18
2.57
2.3
2.6
341.1
5212.9
umol/l
10.66
401
3568
9
25
3.61
2.57
1.1
1.2
—
—
—
0
0
13
50
2.61
2.53
1.1
1.1
—
—
—
0
0
190
1526
1.27
2.47
2.1
2.5
29.9
41.1
u/l
2.50
165
1287
15
63
2.39
2.46
1.2
1.1
110.8
108.6
%
0.11
15
53
18
83
2.18
2.41
1.4
1.4
—
—
—
0
0
66
450
1.48
2.40
1.4
1.5
247.9
292.0
ug/g
1.45
38
258
6
12
5.01
2.40
1.0
1.2
—
—
—
0
0
9
27
3.34
2.39
1.1
1.1
—
—
—
0
0
253
2114
1.23
2.33
1.6
1.8
1.4
1.5
%
0.60
228
1865
8
23
3.49
2.27
1.3
1.3
—
—
—
0
0
52
344
1.53
2.20
1.2
1.2
19.0
42.8
u/ml
—
6
34
375
3271
1.18
2.19
1.7
1.7
447.8
31430035.9
pmol/l
3.06
313
2749
52
346
1.52
2.15
3.2
3.2
34.5
33.8
umol/l
0.07
44
298
311
2674
1.19
2.14
1.3
1.3
4.4
11.8
u/ml
3.96
121
1066
73
522
1.41
2.11
2.3
2.3
742.3
429.4
ug/l
0.48
68
488
21
109
1.94
2.10
1.0
1.2
—
—
—
0
0
56
381
1.48
2.10
4.3
3.1
24.5
25.1
mmol/l
0.56
49
337
14
62
2.27
2.07
1.0
1.2
—
—
—
0
0
22
118
1.87
2.01
1.7
1.4
47.9
58.5
pmol/l
0.24
11
39
34
208
1.65
2.01
1.2
1.2
—
—
—
0
0
53
360
1.49
2.01
1.4
2.4
0.8
0.9
nmol/l
0.09
48
304
7
21
3.34
1.96
1.0
1.7
81.2
108.4
ng/l
—
7
21
531
4795
1.15
1.96
2.9
3.2
7.8
7.8
mmol/l
0.03
456
4058
92
694
1.34
1.95
3.2
3.3
24.7
25.2
mmol/l
0.95
85
666
60
421
1.44
1.94
1.2
1.2
11.7
9.4
u/ml
—
8
69
8
27
2.97
1.93
1.1
1.1
125.1
100.3
%
—
8
27
25
142
1.77
1.93
1.6
1.5
40.0
31.6
%
0.51
20
89
59
415
1.43
1.89
1.2
1.2
2.3
2.6
u/ml
—
5
42
7
22
3.19
1.88
7.9
10.3
5.8
6.4
mmol/l
—
7
22
22
122
1.81
1.84
1.1
1.1
—
—
—
0
0
22
122
1.81
1.84
1.1
1.1
—
—
—
0
0
15
73
2.06
1.80
1.1
1.1
93.6
94.9
%
—
10
57
22
124
1.78
1.76
1.1
1.1
—
—
—
0
0
22
124
1.78
1.76
1.1
1.1
—
—
—
0
0
22
124
1.78
1.76
1.1
1.1
—
—
—
0
0
218
1850
1.20
1.75
8.2
6.8
—
—
—
0
0
6
18
3.34
1.74
1.2
1.2
—
—
—
0
0
40
265
1.52
1.74
1.1
1.1
—
—
—
0
0
216
1833
1.20
1.74
22.6
23.2
1.2
1.3
inr
0.45
37
255
7
24
2.92
1.72
1.1
1.0
—
—
—
0
0
45
307
1.48
1.71
1.2
1.4
—
—
—
0
0
45
307
1.48
1.71
1.2
1.4
—
—
—
0
0
321
2824
1.16
1.69
1.3
1.3
24.6
31.5
iu/ml
0.75
80
893
15
75
2.01
1.69
1.4
2.8
596.3
869.6
u/ml
0.59
15
75
16
82
1.96
1.69
1.5
1.4
—
—
—
0
0
19
104
1.84
1.67
1.2
1.1
—
—
—
0
0
47
326
1.45
1.65
2.7
3.7
4.0
4.2
e9/l
0.41
47
326
24
142
1.70
1.64
7.0
3.7
53.1
53.3
%
0.01
14
105
36
237
1.53
1.63
5.5
3.6
1.2
1.3
%
0.03
29
200
5
14
3.58
1.61
1.2
1.1
—
—
—
0
0
23
136
1.70
1.59
1.1
1.0
308.5
290.8
mg/l
0.47
23
121
46
321
1.44
1.58
2.7
2.3
129.6
131.0
g/l
0.15
33
243
7
27
2.60
1.51
1.1
1.2
—
—
—
0
0
76
582
1.32
1.51
1.2
1.3
235.8
223.0
miu/ml
0.10
27
286
219
1888
1.18
1.50
4.7
4.2
31.4
32.0
%
0.41
170
1304
68
514
1.33
1.48
2.1
2.2
86.8
90.9
%
0.66
62
481
70
534
1.32
1.44
1.5
1.4
—
—
—
0
0
13
66
1.98
1.43
1.0
1.0
—
—
—
0
0
47
337
1.40
1.42
3.0
4.0
55.9
57.7
%
0.49
47
337
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
64
483
1.34
1.42
3.1
3.1
0.4
0.3
u/ml
0.42
42
269
21
126
1.67
1.40
1.1
1.6
0.9
1.2
promille
0.46
15
101
14
74
1.90
1.39
1.0
1.2
—
—
—
0
0
111
909
1.23
1.32
4.5
3.0
132.2
129.4
g/l
0.68
105
883
45
325
1.39
1.32
1.2
1.2
—
10.9
—
0
5
8
34
2.36
1.29
1.3
1.1
—
—
—
0
0
76
956
0.79
1.26
1.5
1.5
—
—
—
0
0
43
313
1.38
1.23
1.3
1.5
101.8
118.2
u/ml
—
9
60
5
19
2.64
1.21
1.0
2.6
—
—
—
0
0
48
357
1.35
1.21
1.5
1.6
—
—
—
0
0
24
157
1.54
1.17
4.0
4.6
515.6
104.4
u/ml
—
5
47
48
361
1.34
1.14
1.1
1.2
—
—
—
0
0
12
65
1.85
1.13
1.5
1.4
—
—
—
0
0
12
65
1.85
1.13
1.5
1.4
—
—
—
0
0
5
111
0.45
1.13
1.2
1.5
—
—
—
0
0
16
96
1.67
1.10
2.8
2.2
—
—
—
0
0
83
675
1.24
1.09
1.5
1.9
1.5
1.5
g/l
0.09
72
591
28
193
1.46
1.09
1.5
1.4
—
—
—
0
0
23
152
1.52
1.09
1.4
1.4
9.6
12.4
mmol/l
—
6
41
14
81
1.73
1.09
1.0
1.0
—
—
—
0
0
35
252
1.40
1.09
1.1
1.1
121.3
115.8
%
0.44
28
231
24
161
1.50
1.06
11.3
6.2
9.3
7.0
mmol/l
0.60
19
130
18
113
1.60
1.05
1.1
1.2
—
—
—
0
0
145
1251
1.17
1.04
2.2
2.4
6.7
6.9
ug/l
0.05
121
1120
16
252
0.63
1.03
4.8
3.9
19.7
29.0
u/ml
0.54
16
246
20
130
1.54
1.02
1.1
1.2
—
—
—
0
0
64
510
1.26
1.02
1.8
1.9
—
—
—
0
0
56
439
1.28
1.01
3.5
3.6
41.6
65.5
mg/l
0.85
44
349
12
68
1.77
1.00
1.3
1.2
—
—
—
0
0
9
48
1.88
1.00
1.0
1.0
—
—
—
0
0
7
35
2.00
1.00
1.0
1.1
—
—
—
0
0
120
1025
1.18
0.98
1.6
1.9
—
—
—
0
0
16
100
1.60
0.96
1.1
1.0
—
—
—
0
0
12
69
1.74
0.96
1.8
1.6
—
1428581.3
—
0
8
72
587
1.24
0.96
2.5
2.0
3.0
1.7
ug/l
0.51
60
521
150
1309
1.16
0.95
1.8
2.0
—
—
—
0
0
26
183
1.43
0.94
1.1
1.1
—
—
—
0
0
16
101
1.59
0.93
2.7
2.1
11.4
13.0
%
—
5
49
27
192
1.41
0.92
1.5
1.4
—
—
—
0
0
27
192
1.41
0.92
1.5
1.4
—
—
—
0
0
12
70
1.72
0.92
2.2
3.7
77.4
138.9
umol/l
—
7
41
140
1602
0.86
0.92
1.7
1.7
—
—
—
0
0
19
126
1.51
0.91
1.3
1.7
—
—
—
0
0
27
193
1.40
0.90
1.5
1.4
—
—
—
0
0
136
1186
1.16
0.88
2.8
2.8
122.8
191.7
ng/l
2.42
122
1072
55
440
1.26
0.88
3.5
3.6
32.7
68.6
mg/l
0.63
44
351
20
136
1.48
0.86
1.1
1.3
—
—
—
0
0
8
44
1.82
0.86
1.4
1.1
—
—
—
0
0
27
196
1.38
0.84
1.5
1.4
—
—
—
0
0
57
700
0.81
0.84
1.8
1.7
3.3
4.2
mg/l
0.38
41
490
27
197
1.38
0.82
1.5
1.4
—
—
—
0
0
0
25
0.00
0.79
0.0
2.9
—
0.7
—
0
25
8
48
1.67
0.78
1.6
1.3
—
—
—
0
0
51
628
0.81
0.78
1.5
1.4
—
—
—
0
0
30
226
1.33
0.76
3.4
2.7
300.8
79.0
u/ml
0.33
30
209
27
201
1.35
0.74
1.3
1.1
—
—
—
0
0
30
228
1.32
0.73
1.1
1.1
—
—
—
0
0
15
100
1.50
0.73
1.7
1.5
1.9
7.7
u/l
—
9
51
222
2028
1.11
0.72
2.0
2.0
—
—
—
0
0
51
419
1.22
0.68
1.4
1.4
—
—
—
0
0
5
27
1.85
0.68
4.0
2.9
—
—
—
0
0
7
44
1.59
0.65
6.3
2.5
—
—
—
0
0
32
251
1.28
0.64
1.3
1.3
—
—
—
0
0
29
225
1.29
0.63
1.2
1.7
—
—
—
0
0
6
102
0.59
0.62
1.5
1.1
—
—
—
0
0
6
103
0.58
0.62
1.5
1.3
—
—
—
0
0
69
591
1.17
0.62
1.3
1.4
—
—
—
0
0
13
88
1.48
0.60
1.2
1.4
11.6
13.7
u/l
0.95
13
83
1545
15224
1.07
0.60
18.4
14.2
40.2
40.0
%
0.44
1152
11391
8
52
1.54
0.59
2.4
1.4
12.0
8.7
ug/l
—
8
52
10
64
1.57
0.58
3.1
4.3
—
—
—
0
0
33
264
1.25
0.58
1.1
1.1
—
—
—
0
0
243
2259
1.09
0.58
2.1
2.1
—
—
—
0
0
17
123
1.39
0.58
1.0
1.4
—
—
—
0
0
47
392
1.20
0.57
1.5
1.6
—
—
—
0
0
20
264
0.76
0.57
3.1
3.2
0.8
0.8
nmol/l
0.03
14
209
6
36
1.67
0.56
1.0
1.1
—
—
—
0
0
23
176
1.31
0.56
1.2
1.8
—
—
—
0
0
12
82
1.47
0.54
1.2
1.3
—
950.0
—
0
7
33
404
0.81
0.53
1.3
1.2
—
—
—
0
0
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
6
39
1.54
0.53
1.0
1.2
—
68.2
—
0
11
6
39
1.54
0.53
1.0
1.2
—
82.7
—
0
12
38
457
0.83
0.52
1.3
1.5
—
—
—
0
0
6
40
1.50
0.51
2.8
1.9
—
—
—
0
0
41
343
1.20
0.50
1.1
1.3
148.5
257.8
u/ml
3.93
22
212
45
380
1.19
0.50
1.6
1.6
—
—
—
0
0
7
45
1.56
0.49
3.1
2.5
—
—
—
0
0
7
45
1.56
0.49
3.1
2.5
—
—
—
0
0
11
76
1.45
0.48
2.3
2.6
—
—
—
0
0
35
290
1.21
0.47
1.2
1.5
—
—
—
0
0
34
282
1.21
0.46
1.6
1.7
—
—
—
0
0
17
221
0.77
0.46
1.2
1.6
—
—
—
0
0
14
104
1.35
0.43
1.1
1.2
—
—
—
0
0
15
113
1.33
0.42
1.3
1.1
—
2.0
—
0
7
8
56
1.43
0.42
1.6
1.3
—
—
—
0
0
70
623
1.13
0.42
1.7
1.8
—
—
—
0
0
55
482
1.15
0.41
2.3
2.8
—
—
—
0
0
29
348
0.83
0.41
1.1
1.5
—
—
—
0
0
0
17
0.00
0.40
0.0
1.0
—
—
—
0
0
51
446
1.15
0.40
1.1
1.1
—
—
—
0
0
269
2830
0.94
0.39
1.4
1.5
—
—
—
0
0
20
160
1.25
0.38
1.8
1.6
—
—
—
0
0
5
36
1.39
0.38
2.0
5.3
63.8
72.2
%
—
5
29
48
546
0.88
0.37
1.4
1.5
—
—
—
0
0
35
299
1.17
0.37
2.2
1.5
—
—
—
0
0
40
346
1.16
0.37
1.3
1.4
—
—
—
0
0
30
253
1.19
0.36
1.0
1.0
1.5
2.4
u/ml
0.59
16
118
60
535
1.13
0.36
1.8
1.7
—
—
—
0
0
44
502
0.87
0.36
1.4
1.4
—
—
—
0
0
44
501
0.88
0.35
1.4
1.4
—
—
—
0
0
18
222
0.81
0.34
1.2
1.2
—
—
—
0
0
44
500
0.88
0.34
1.4
1.4
—
—
—
0
0
478
4628
1.04
0.34
3.7
4.0
8.9
9.2
mg/mmol
0.03
299
2959
44
499
0.88
0.34
1.4
1.4
—
—
—
0
0
24
286
0.84
0.33
1.3
1.5
—
—
—
0
0
52
463
1.13
0.33
1.3
1.3
—
—
—
0
0
22
182
1.21
0.33
1.9
2.2
16.0
27.2
mg/l
—
6
45
7
52
1.35
0.31
1.0
1.3
—
—
—
0
0
27
231
1.17
0.29
2.8
2.1
11.0
4.7
umol/l
0.62
22
165
22
260
0.84
0.29
1.2
1.1
—
—
—
0
0
32
279
1.15
0.28
1.6
1.7
—
—
—
0
0
14
112
1.25
0.28
1.4
1.2
—
—
—
0
0
14
113
1.24
0.26
1.4
1.3
—
—
—
0
0
5
71
0.70
0.26
1.6
2.1
17.2
137.7
ug/l
—
5
59
18
151
1.19
0.25
2.3
2.5
—
—
—
0
0
51
559
0.91
0.24
1.5
1.4
—
—
—
0
0
14
115
1.22
0.23
1.4
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
5.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
11.2
—
0
10
38
418
0.91
0.20
1.6
1.7
—
—
—
0
0
10
80
1.25
0.20
1.7
2.0
—
—
—
0
0
49
531
0.92
0.20
4.0
3.4
370.8
2722.0
u/ml
0.67
38
458
9
115
0.78
0.20
1.0
1.4
—
—
—
0
0
20
174
1.15
0.19
1.8
1.6
—
—
—
0
0
21
239
0.88
0.19
1.2
1.3
7.7
7.2
mmol/l
0.36
16
169
27
241
1.12
0.19
1.2
1.1
1.4
1.5
g/l
0.18
27
219
36
329
1.10
0.17
3.1
3.6
24.5
25.1
mg/l
0.04
20
209
41
378
1.09
0.17
2.1
1.7
10570.1
12661.6
e6/l
0.16
32
284
7
63
1.11
0.17
3.0
1.6
—
—
—
0
0
7
63
1.11
0.17
3.0
1.6
—
—
—
0
0
329
3214
1.03
0.17
1.7
1.5
—
—
—
0
0
8
72
1.11
0.16
1.0
1.1
158.2
220.5
iu/ml
—
8
72
11
130
0.85
0.16
1.2
1.3
6.8
6.5
mmol/l
0.12
11
120
11
130
0.85
0.16
1.0
1.8
—
—
—
0
0
55
516
1.07
0.15
1.6
1.6
0.1
0.2
iu/ml
0.05
11
91
87
829
1.05
0.15
3.0
3.1
372.2
55.1
u/ml
0.44
82
800
11
93
1.18
0.14
1.0
1.7
0.5
4.6
u/field
—
6
72
7
89
0.79
0.14
1.3
1.4
17.0
34.7
nmol/l
—
7
72
15
132
1.14
0.13
1.7
1.5
0.9
1.0
g/l
0.08
15
132
29
267
1.09
0.13
1.6
1.2
15.1
5.5
u/ml
0.76
12
116
10
85
1.18
0.12
1.2
1.7
—
—
—
0
0
10
85
1.18
0.12
1.2
1.7
—
—
—
0
0
87
904
0.96
0.11
1.3
1.4
—
—
—
0
0
10
115
0.87
0.10
8.4
13.9
858.1
824.1
nmol/l
—
10
110
10
115
0.87
0.10
1.4
1.7
—
—
—
0
0
12
106
1.13
0.09
1.1
1.8
—
—
—
0
0
347
3421
1.02
0.09
3.7
3.9
1.0
1.0
kg/l
1.39
45
471
16
145
1.10
0.09
1.4
1.6
7.9
7.5
mmol/l
—
7
88
47
491
0.96
0.08
1.2
1.2
—
—
—
0
0
7
64
1.09
0.08
3.1
1.6
—
—
—
0
0
8
78
1.03
0.07
1.3
1.1
1180.6
1631.6
miu/ml
—
8
78
16
147
1.09
0.07
1.1
1.2
0.2
0.6
u/ml
—
7
66
25
265
0.94
0.07
1.6
1.6
—
—
—
0
0
9
101
0.89
0.06
16.0
11.6
0.7
0.6
mmol/l
—
9
93
30
287
1.05
0.05
1.1
1.1
10.1
1827.8
iu/ml
—
10
72
147
1449
1.02
0.05
3.8
4.2
100.2
25.5
ug/l
0.59
111
1177
24
251
0.96
0.04
1.3
1.5
—
—
—
0
0
18
171
1.05
0.03
1.2
1.2
—
—
—
0
0
91
897
1.02
0.03
1.0
1.0
—
—
—
0
0
48
490
0.98
0.02
1.2
1.2
—
—
—
0
0
34
349
0.97
0.02
1.1
1.1
1.4
2.0
u/ml
0.28
13
144
16
153
1.05
0.01
1.1
1.0
—
—
—
0
0
14
146
0.96
0.00
4.3
3.7
—
—
—
0
0
28
274
1.02
0.00
1.5
1.2
2.3
4.3
u/ml
—
9
93
12
125
0.96
0.00
2.1
2.2
617.0
637.7
ml
—
6
78
37
374
0.99
0.00
2.6
2.4
179.8
106.4
ug/min
0.38
15
232
13
128
1.02
0.00
1.2
2.1
0.9
2.2
u/field
—
7
63
13
127
1.02
0.00
1.1
1.1
—
—
—
0
0
14
143
0.98
0.00
2.1
1.4
—
—
—
0
0
14
143
0.98
0.00
2.1
1.4
—
—
—
0
0
14
143
0.98
0.00
2.1
1.4
—
—
—
0
0
22
217
1.01
0.00
1.2
1.5
—
—
—
0
0
8
81
0.99
0.00
2.8
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
2.6
—
4.3
—
0
8
8
81
0.99
0.00
1.0
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
8
81
0.99
0.00
2.8
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
8
81
0.99
0.00
1.0
1.9
—
—
—
0
0
8
81
0.99
0.00
2.8
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
4.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
1296.7
—
0
7
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
10
100
1.00
0.00
1.2
1.6
—
—
—
0
0
8
81
0.99
0.00
2.8
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
2.2
—
0
5
7
76
0.92
0.00
1.7
2.9
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_PITUITARY_CRANIPHAR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_PITUITARY_CRANIPHAR | 1.615 [1.4, 1.86] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.242 |
During the follow-up period (1.1.1998 — 31.12.2019), 512 out of 4286 females with CD2_BENIGN_PITUITARY_CRANIPHAR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_PITUITARY_CRANIPHAR | 1.312 [1.15, 1.5] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 610 out of 3161 males with CD2_BENIGN_PITUITARY_CRANIPHAR died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_PITUITARY_CRANIPHAR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.146% | 0.276% |
| 5 | 0.905% | 1.452% |
| 10 | 2.203% | 3.392% |
| 15 | 4.48% | 6.597% |
| 20 | 7.905% | 11.263% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_PITUITARY_CRANIPHAR – Benign neoplasm: Pituitary gland, craniopharyngeal duct
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data