Toxic Nodular Goiter: Nodular enlargement of the thyroid gland associated with hyperthyroidism.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2361 |
4. Check minimum number of eventsNone |
2361 |
5. Include endpointsNone |
2361 |
6. Filter based on genotype QC (FinnGen only) |
2305 |
Control definitions (FinnGen only)
- Control exclude
- THYROTOXICOSIS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E05
- Name in latin
- Thyreotoxicosis cum struma multinodulari
Similar endpoints
↥List of similar endpoints to
Thyrotoxicosis with toxic multinodular goitre
based on the number of shared cases.
Similar with more cases:
- Thyrotoxicosis
- Disorders of thyroid, IBD co-morbidities
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 18329 | 15393 | 2783 |
| Only index persons | 14535 | 12435 | 2100 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.38 | 0.44 | 0.08 |
| Only index persons | 0.40 | 0.46 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 60.94 | 60.51 | 63.51 |
| Only index persons | 60.38 | 59.55 | 65.30 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2305 | 1867 | 438 |
| Unadjusted period prevalence (%) | 0.57 | 0.66 | 0.20 |
| Median age at first event (years) | 61.77 | 60.44 | 67.45 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 2361
- Matched controls
- 23610
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
35.1
307.7
418
144
H03BB01
ATC
carbimazole; oral
894.1
307.7
1501
46
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
10.3
307.7
439
512
H03AA01
ATC
levothyroxine sodium; systemic
6.4
307.7
1414
4483
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
9345.1
307.7
1986
7
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
1260.9
307.7
709
8
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
142.4
307.7
196
15
104
Kela drug reimbursment
Thyroid insufficiency
7.8
307.7
679
1155
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
57.8
307.7
211
40
24210
ICD-8 Finland
Thyrotoxicosis with or without goitre, Toxic nodular goitre
+∞
307.7
325
*
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
101.9
307.7
179
19
BAA60
NOMESCO Finland
Total thyroidectomy
39.6
307.7
565
186
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
7641.5
307.7
591
*
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
18.7
287.4
234
138
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
420.4
267.9
264
7
T85
ICPC
Hyperthyroidism/thyrotoxicosis
35.4
186.9
118
35
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
9.4
185.6
231
268
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
9.3
117.5
145
165
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
57.9
110.1
62
11
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.1
94.9
281
745
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
17.6
79.2
65
38
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
+∞
76.5
73
*
C07AA05
ATC
propranolol; systemic
2.4
68.8
619
3054
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
65.9
63
*
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
9.3
64.5
78
86
T86
ICPC
Hypothyroidism/myxoedema
3.7
61.8
207
594
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
21.8
60.5
45
21
E03.89
ICD-10 Finland
Other specified hypothyroidism
3.8
60.1
193
538
2422A
ICD-9 Finland
Thyrotoxicosis with or without goitre, Toxic multinodular goitre
+∞
57.5
55
*
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
4.9
56.2
128
274
2505
FHL
Bilateral resection (also used if total removal has been performed on the other side)
10.2
55.0
62
62
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.3
54.5
489
2383
R94.6
ICD-10 Finland
Abnormal results of thyroid function studies
17.0
54.0
45
27
C07AB07
ATC
bisoprolol; oral
2.0
53.7
1361
9689
T81
ICPC
Goitre
13.3
49.5
47
36
A11CC03
ATC
alfacalcidol; systemic
5.0
47.8
104
214
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
5.5
42.0
82
153
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.8
41.6
129
350
E05.89
ICD-10 Finland
Other thyrotoxicosis
+∞
40.7
39
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
38.6
1078
7619
E03
ICD-10 Finland
Other hypothyroidism
2.6
36.7
229
936
WX402
NOMESCO Finland
General anaesthesia
1.9
34.4
523
3052
E04.8
ICD-10 Finland
Other specified nontoxic goitre
12.5
32.4
32
26
E83.51
ICD-10 Finland
Hypocalcemia
7.9
31.5
43
55
106
Kela drug reimbursment
Hypoparathyroidism
9.6
30.6
36
38
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
4.1
29.2
82
207
BAA25
NOMESCO Finland
Bilateral partial excision of thyroid gland
28.9
27.6
37
13
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.7
27.1
575
3683
BA1AE, ,
SPAT
6.6
25.6
41
63
H062, E050,
ICD-10 Finland
+∞
25.0
24
*
24209
ICD-8 Finland
Thyrotoxicosis with or without goitre, Cum struma diffuse NUD
+∞
22.9
22
*
24199
ICD-8 Finland
Non-toxic nodular goitre, Unspecified
4.3
22.6
58
137
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
22.0
883
6562
H03BA02
ATC
propylthiouracil; oral
+∞
21.9
21
*
E04
ICD-10 Finland
Other nontoxic goitre
8.3
21.4
28
34
ZXD10
NOMESCO Finland
Scheduled procedure
1.5
21.3
929
7020
ZXA10
NOMESCO Finland
Bilateral
1.7
20.8
495
3240
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
6.0
20.4
36
61
207
Kela drug reimbursment
Chronic arrhythmias
1.7
19.7
418
2650
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
201.6
19.6
20
*
XW1AT
NOMESCO Finland
Biopsy from other organ close to skin with ultrasound quidance
5.8
18.8
34
59
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.7
18.8
430
2778
24200
ICD-8 Finland
Thyrotoxicosis with or without goitre, Cum struma diffusa et exophthalmo. Morbus Basedowi
+∞
18.8
18
*
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.7
18.7
391
2467
R06.0
ICD-10 Finland
Dyspnoea
1.5
18.6
677
4884
Z3231
NOMESCO Finland
Registered nurse
1.6
18.5
638
4548
B01AA03
ATC
warfarin; systemic
1.6
17.9
460
3060
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.6
17.7
499
3392
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
3.9
16.7
49
128
Z2221
NOMESCO Finland
Medical doctor
1.5
16.7
633
4589
BAA50
NOMESCO Finland
Lobectomy and resection of contralateral lobe of thyroid gland
18.6
16.0
24
13
N02BE01
ATC
paracetamol; systemic, rectal
1.7
16.0
2097
19362
GB1AA
NOMESCO Finland
Tracheal X-ray examination
26.5
15.6
21
8
ZXE00
NOMESCO Finland
One hour or less
1.4
15.5
878
6869
TFP20
NOMESCO Finland
Cardiodefibrillation
2.0
15.5
173
897
I50.9
ICD-10 Finland
Heart failure, unspecified
1.6
15.3
360
2334
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.6
15.2
426
2882
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
1.9
15.1
209
1166
I10
ICD-10 Finland
Essential (primary) hypertension
1.4
14.9
1491
12879
R53
ICD-10 Finland
Malaise and fatigue
1.5
14.6
561
4060
24220
ICD-8 Finland
Thyrotoxicosis with or without goitre, Thyrotoxicosis without mention of goitre
+∞
14.6
14
*
Z71.8
ICD-10 Finland
Other specified counselling
1.5
14.4
661
4955
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
14.4
571
4161
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
3.7
14.3
44
119
R4110
NOMESCO Finland
Physiotherapy
1.5
14.2
645
4824
A12AA04
ATC
calcium carbonate; oral
3.6
13.5
44
124
C03CA01
ATC
furosemide; systemic
1.4
13.3
771
6020
H05.2
ICD-10 Finland
Exophthalmic conditions
19.1
12.9
19
10
24400
ICD-8 Finland
Myxoedema, (hypothyreosis) post therapiam
32.2
12.6
16
5
E05.5
ICD-10 Finland
Thyroid crisis or storm
+∞
12.5
12
*
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
1.8
12.5
198
1151
C07AA07
ATC
sotalol; systemic
2.2
12.4
99
451
R00.2
ICD-10 Finland
Palpitations
1.8
12.3
183
1043
B01AF02
ATC
apixaban; oral
1.6
12.3
313
2063
E07.9
ICD-10 Finland
Disorder of thyroid, unspecified
8.7
12.0
25
29
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
4.0
11.9
33
83
R03BB04
ATC
tiotropium bromide; inhalant
1.7
11.5
231
1434
C07AB02
ATC
metoprolol; systemic
1.5
11.4
497
3665
D35.0
ICD-10 Finland
Benign neoplasm: Adrenal gland
3.1
11.3
47
155
R00.0
ICD-10 Finland
Tachycardia, unspecified
2.2
11.2
98
464
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
2.4
11.2
78
336
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.3
11.1
1044
8744
C01BD01
ATC
amiodarone; systemic
2.6
10.9
62
243
B01AB05
ATC
enoxaparin; parenteral
1.4
10.8
743
5926
ZXA05
NOMESCO Finland
Left side
1.4
10.8
587
4504
BBA70
NOMESCO Finland
Implantation or transplantation of parathyroid gland
17.9
10.7
16
9
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.6
10.5
233
1484
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
+∞
10.4
10
*
A02BC02
ATC
pantoprazole; systemic
1.4
10.4
1569
14040
L28
ICPC
Limited function/disability (L)
1.4
10.3
452
3331
XF404
NOMESCO Finland
Ambulatory ECG
1.7
10.3
200
1230
E89.0
ICD-10 Finland
Postprocedural hypothyroidism
16.8
9.9
15
9
K78
ICPC
Atrial fibrillation/flutter
1.7
9.9
184
1120
A11CC02
ATC
dihydrotachysterol; oral
8.8
9.8
20
23
Z01.7
ICD-10 Finland
Laboratory examination
1.5
9.5
312
2172
H02AB06
ATC
prednisolone; systemic
1.3
9.4
1044
8885
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
1.7
9.4
168
1012
K80
ICPC
Cardiac arrhythmia NOS
1.6
9.3
194
1218
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.4
9.2
533
4115
C03DA01
ATC
spironolactone; oral
1.5
9.2
279
1909
A10BH05
ATC
linagliptin; oral
1.9
9.2
119
651
A04
ICPC
Weakness/tiredness general
1.5
9.1
330
2344
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.3
9.0
762
6231
A27
ICPC
Fear of other disease NOS
1.9
8.9
117
643
C01AA05
ATC
digoxin; systemic
1.6
8.9
195
1239
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.3
8.8
875
7316
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.4
8.8
595
4706
TPH04
NOMESCO Finland
Cathetrisation of vein
1.4
8.7
460
3496
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.4
8.7
438
3303
A91
ICPC
Abnormal result investigation NOS
1.9
8.5
113
623
Z04.9
ICD-10 Finland
Examination and observation for unspecified reason
1.9
8.4
100
532
J01DA01
ATC
[U] cefalexin
1.3
8.4
1343
11929
Z3226
NOMESCO Finland
Physiotherapist
1.4
8.1
398
2987
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.3
8.1
640
5173
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
1.9
8.0
95
505
J01DB01
ATC
cefalexin; oral
1.3
8.0
1805
16723
D34
ICD-10 Finland
Benign neoplasm of thyroid gland
3.7
8.0
25
69
R03AC02
ATC
salbutamol; inhalant
1.3
7.9
1181
10361
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
1.6
7.9
209
1388
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.4
7.9
324
2354
T90
ICPC
Diabetes non-insulin dependent
1.4
7.8
502
3929
XF600
NOMESCO Finland
Bloodpressure measurement
1.7
7.8
128
754
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.5
7.8
271
1908
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.3
7.7
1069
9283
A10BA02
ATC
metformin; oral
1.3
7.7
601
4842
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
2.1
7.7
70
339
L40.3
ICD-10 Finland
Pustulosis palmaris et plantaris
2.8
7.7
37
134
G47.3
ICD-10 Finland
Sleep apnoea
1.4
7.6
390
2942
E21.0
ICD-10 Finland
Primary hyperparathyroidism
2.3
7.6
54
236
BAA20
NOMESCO Finland
Unilateral partial excision of thyroid gland
6.2
7.5
19
31
K04
ICPC
Palpitations/awareness of heart
1.8
7.5
119
694
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
1.9
7.4
89
476
C08CA01
ATC
amlodipine; oral
1.3
7.4
890
7582
E83.50
ICD-10 Finland
Hypercalcemia
2.7
7.4
39
148
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.4
7.4
380
2871
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
1.7
7.3
129
774
R02
ICPC
Shortness of breath/dyspnoea
1.4
7.3
287
2065
R21
ICPC
Throat symptom/complaint
1.4
7.3
353
2639
2419X
ICD-9 Finland
Non-toxic nodular goitre, Unspecified non-toxic nodular goitre
4.2
7.3
19
46
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
1.6
7.3
188
1243
TPH07
NOMESCO Finland
Cathetrisation of artery
1.5
7.2
230
1592
M03BX02
ATC
tizanidine; oral
1.3
7.1
1287
11493
A02BC05
ATC
esomeprazole; systemic
1.3
7.1
899
7694
M79.6
ICD-10 Finland
Pain in limb
1.3
7.1
914
7844
2504
FHL
Unilateral resection or enucleation
3.0
7.0
29
96
205
Kela drug reimbursment
Chronic hypertension
1.3
7.0
623
5097
N02AJ06
ATC
codeine and paracetamol; systemic
1.3
7.0
845
7189
R4130
NOMESCO Finland
Speech therapy
2.2
7.0
56
258
UDQ12
NOMESCO Finland
Flexible laryngoscopy
1.7
7.0
114
671
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.4
6.9
397
3049
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.3
6.9
493
3914
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
1.8
6.8
98
556
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.4
6.8
394
3032
ZXE20
NOMESCO Finland
More than three and less than five hours
1.4
6.8
273
1975
BWD00
NOMESCO Finland
Reoperation for deep haemorrhage in endocrine surgery
40.2
6.8
8
*
M04AA01
ATC
allopurinol; systemic
1.5
6.7
247
1756
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
2.1
6.7
61
296
2411A
ICD-9 Finland
Non-toxic nodular goitre, Non-toxic multinodular goitre
3.7
6.6
20
54
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.3
6.6
512
4107
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
2.2
6.6
52
238
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
1.7
6.6
113
675
XCK10
NOMESCO Finland
Photography of fundus of eye
1.5
6.5
207
1429
J01FA10
ATC
azithromycin; systemic
1.2
6.5
1166
10355
ZX114
NOMESCO Finland
Intramuscular
2.8
6.5
32
117
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.5
6.5
181
1215
D44.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Adrenal gland
2.9
6.5
29
101
XF400
NOMESCO Finland
ECG with 12 standard connections
1.4
6.4
319
2392
H03BB02
ATC
thiamazole; oral
70.0
6.4
7
*
J01AA02
ATC
doxycycline; systemic
1.3
6.4
1750
16306
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.3
6.4
473
3771
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
2.8
6.3
30
108
E05.3
ICD-10 Finland
Thyrotoxicosis from ectopic thyroid tissue
+∞
6.3
6
*
BA1AN
NOMESCO Finland
Thyroid gland isotope imaging
+∞
6.3
6
*
2420A
ICD-9 Finland
Thyrotoxicosis with or without goitre, Toxic diffuse goitre
+∞
6.3
6
*
Z01.8
ICD-10 Finland
Other specified special examinations
1.3
6.2
463
3690
C09AA02
ATC
enalapril; systemic
1.3
6.2
416
3266
E20.8
ICD-10 Finland
Other hypoparathyroidism
26.7
6.2
8
*
WW200
NOMESCO Finland
Immunization
2.2
6.2
50
232
J45.1
ICD-10 Finland
Nonallergic asthma
1.6
6.1
156
1028
SPAT1249
SPAT
Treatment-related counselling outside office
1.3
6.1
810
6941
R13
ICD-10 Finland
Dysphagia
1.6
6.0
148
967
EP1AE, ,
SPAT
2.6
6.0
33
128
K85
ICPC
Elevated blood pressure
1.3
6.0
382
2976
C03AA03
ATC
hydrochlorothiazide; oral
1.4
6.0
224
1597
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
1247
1007
25.13
307.65
5.3
2.4
4.86
4.30
pmol/l
36.95
1161
857
1002
261
65.96
307.65
1.8
1.2
23.19
2.27
iu/l
0.88
325
50
577
1216
5.96
270.79
1.3
1.2
99.76
128.57
iu/ml
0.75
180
429
2149
15749
5.06
129.88
12.0
4.1
15.77
14.91
pmol/l
36.85
2068
14155
235
547
4.66
93.92
1.2
1.2
—
—
—
0
0
1599
10755
2.51
93.09
7.6
6.4
1.21
1.22
mmol/l
2.11
1385
9064
455
1793
2.90
81.44
3.3
3.4
69.80
86.60
ng/l
3.87
401
1489
1439
9753
2.22
74.50
6.6
5.7
1.21
1.22
mmol/l
2.49
1359
8763
2184
18552
3.36
57.28
13.4
5.0
1.43
2.13
mu/l
8.03
2095
16771
1562
11581
2.03
55.72
8.7
8.9
4.02
4.05
e9/l
0.17
1334
10065
54
59
9.34
44.89
1.6
1.6
15.87
14.85
pmol/l
0.79
49
47
1248
9054
1.80
42.11
2.6
2.3
77.90
79.97
nmol/l
1.90
1138
7985
85
180
4.86
37.77
4.1
4.6
209.20
56.15
u/ml
0.74
19
53
1796
15067
1.80
31.79
4.4
4.3
13.63
13.63
mm/h
0.00
1700
13789
1150
8710
1.62
28.68
10.4
9.6
0.00
0.00
e9/l
1.46
921
7053
1460
11860
1.61
26.16
5.1
4.5
6.74
6.70
mmol/l
0.43
1397
11101
737
5110
1.64
25.49
4.2
3.7
88.83
91.19
%
1.59
722
4971
845
6075
1.61
25.14
3.8
3.2
93.47
71.39
e6/l
0.17
638
4613
1830
15808
1.70
24.84
8.2
7.5
78.68
78.91
u/l
0.10
1761
14740
1005
7610
1.56
23.46
3.5
3.5
2.35
2.36
mmol/l
1.45
895
6572
951
7157
1.55
22.56
4.4
3.7
106.15
116.88
e6/l
0.16
677
4969
1273
10219
1.53
22.37
5.7
5.8
0.19
0.19
e9/l
0.38
1104
8832
1171
9254
1.53
21.99
5.8
5.8
2.80
2.81
%
0.04
1083
8558
1195
9503
1.52
21.67
5.8
5.9
26.72
27.63
%
2.24
1111
8821
1886
16651
1.66
20.95
24.2
17.9
15.02
15.24
%
0.87
1859
16332
773
5635
1.55
20.72
3.6
3.1
0.34
0.53
e6/l
2.42
576
4257
1176
9376
1.51
20.69
5.6
5.7
58.45
57.46
%
2.23
1093
8691
1246
10090
1.50
20.08
5.6
5.7
1.80
1.91
e9/l
1.67
1070
8822
412
2604
1.71
19.65
5.0
5.2
1.04
1.04
mmol/l
0.05
376
2381
689
4957
1.55
19.32
2.3
2.2
—
—
—
0
0
482
3199
1.64
19.00
3.1
2.8
3.91
3.32
e6/l
0.44
259
1687
1170
9435
1.48
18.73
2.6
2.5
—
—
—
0
0
1190
9635
1.47
18.62
21.2
15.3
1.33
1.26
inr
1.60
357
2709
489
3325
1.59
17.27
3.1
3.1
0.79
0.81
mmol/l
6.33
457
3073
1130
9186
1.44
16.56
4.7
4.5
34.96
35.19
g/l
0.76
1053
8491
569
4048
1.53
16.35
4.3
3.8
408.45
276.08
ng/l
0.23
467
3247
495
3423
1.56
16.14
1.8
1.8
—
—
—
0
0
406
2709
1.60
15.35
2.5
2.5
21.12
21.83
%
0.41
350
2285
493
3449
1.54
15.15
3.0
2.7
1.06
1.42
e6/l
1.21
268
1923
351
2268
1.64
15.11
2.5
2.6
7.00
7.91
umol/l
0.49
306
1945
2110
19570
1.74
15.10
18.9
15.0
22.91
23.34
mg/l
0.24
1821
15599
2020
18533
1.62
14.99
18.6
14.2
76.82
76.50
ml/min/173m2
0.27
1754
15261
824
6416
1.44
14.76
3.3
3.0
1506.00
1429.59
ng/l
0.22
730
5490
363
2385
1.62
14.58
1.8
1.7
—
—
—
0
0
586
4282
1.49
14.58
3.1
2.5
6.32
6.73
e6/l
0.31
514
3813
363
2386
1.62
14.55
1.8
1.7
—
—
—
0
0
1092
8957
1.41
14.51
2.1
2.1
93.98
95.74
pmol/l
0.56
560
4283
421
2899
1.55
13.77
2.5
2.4
2.32
2.33
g/l
0.11
386
2664
449
3164
1.52
13.15
2.6
2.4
12.29
12.52
umol/l
0.18
421
2936
2172
20440
1.78
13.04
22.6
17.5
139.81
139.65
mmol/l
2.20
2143
19886
184
1041
1.83
12.69
6.7
7.9
25.19
24.53
mmol/l
1.83
184
1007
1017
8374
1.38
12.58
3.2
2.8
116.55
120.45
ug/l
0.22
940
7639
289
1859
1.63
12.56
2.2
2.2
359.68
374.58
nmol/l
0.64
270
1680
433
3055
1.51
12.56
2.1
2.0
30.25
29.67
s
1.01
421
2949
1264
10778
1.37
12.56
5.7
6.0
10.77
11.07
umol/l
0.63
1219
10174
2173
20488
1.76
12.46
22.8
17.6
3.94
3.96
mmol/l
3.05
2140
19901
291
1882
1.62
12.37
2.3
2.3
32.15
38.03
u/l
1.35
245
1605
285
1835
1.63
12.33
4.0
3.6
1.23
1.23
mmol/l
0.42
255
1583
569
4272
1.44
11.96
3.2
3.1
2.46
2.46
mmol/l
0.07
487
3753
1980
18296
1.51
11.92
6.9
6.0
40.47
40.02
mmol/mol
1.40
1840
16689
1555
13776
1.38
11.77
6.0
5.0
1578.59
2647.16
e6/l
0.37
27
192
2184
20711
1.73
11.05
13.0
10.9
23.48
24.03
u/l
0.94
2141
19851
283
1874
1.58
10.86
3.2
2.9
257.54
208.27
ng/l
0.80
250
1711
2055
19228
1.53
10.73
5.3
4.9
6.05
5.94
mmol/l
3.55
1878
17265
208
1293
1.67
10.30
1.8
1.7
—
—
—
0
0
66
274
2.45
10.29
1.7
1.4
33.00
32.47
g/l
0.13
60
248
115
599
1.97
10.23
1.5
2.3
0.01
0.00
g/l
0.50
102
548
122
649
1.93
10.21
1.6
2.3
0.03
0.02
g/l
0.08
108
595
87
417
2.13
9.71
2.1
2.0
4.76
4.98
mmol/24h
0.26
79
348
112
592
1.94
9.56
1.5
2.3
0.00
0.00
g/l
-0.00
102
547
133
745
1.83
9.50
1.6
2.4
0.33
1.01
g/l
3.17
111
639
296
2042
1.51
9.40
6.1
7.1
94.61
95.59
%
1.13
290
1967
330
2333
1.48
9.30
6.0
6.7
11.91
12.32
kpa
0.75
322
2219
330
2333
1.48
9.30
6.0
6.7
5.28
5.10
kpa
2.03
324
2218
329
2325
1.48
9.29
6.0
6.7
1.57
1.31
mmol/l
0.60
284
1845
277
1889
1.53
9.29
6.6
7.5
120.71
119.06
g/l
0.68
272
1837
2082
19645
1.51
9.27
5.5
5.2
2.67
2.75
mmol/l
4.00
1930
17790
481
3649
1.40
9.25
1.4
1.4
2.25
2.42
g/l
1.09
265
2082
92
464
2.02
8.99
1.3
1.3
—
—
—
0
0
92
464
2.02
8.99
1.3
1.3
—
—
—
0
0
662
5313
1.34
8.89
2.4
2.3
3.05
3.08
mg/l
0.14
571
4495
123
687
1.83
8.89
1.5
2.2
36.38
37.56
g/l
1.61
102
591
2225
21366
1.72
8.64
29.7
22.4
39.62
39.20
%
2.25
2116
19822
85
425
2.04
8.53
1.4
1.4
—
—
—
0
0
121
682
1.82
8.50
1.6
3.3
126.27
49.17
mg/l
0.38
104
557
46
177
2.63
8.44
1.5
1.3
387.09
303.74
u/l
0.26
46
170
319
2283
1.46
8.42
3.9
3.9
234.66
247.50
u/l
0.95
294
2143
2225
21382
1.70
8.40
29.8
22.4
6.80
6.68
e9/l
1.24
2178
20696
2225
21385
1.70
8.35
29.8
22.4
4.45
4.39
e12/l
9.06
2174
20705
2225
21389
1.70
8.29
30.0
22.5
133.01
131.94
g/l
3.20
2207
21028
2224
21377
1.70
8.29
29.8
22.4
256.30
255.03
e9/l
0.42
2184
20767
120
681
1.80
8.25
1.6
3.3
46.27
150.68
mg/l
0.68
104
558
544
4280
1.35
8.24
1.3
1.3
1.56
1.49
u/ml
0.06
127
1077
137
811
1.73
8.16
1.7
2.4
3.22
2.98
g/l
1.92
116
718
39
141
2.80
8.07
1.5
1.3
11.31
11.85
u/l
0.10
39
124
117
668
1.79
7.90
1.6
3.2
1.91
1.64
ratio
—
9
56
775
6446
1.30
7.89
3.8
3.7
11.24
8.66
mg/mmol
0.54
474
3777
262
1831
1.48
7.79
4.0
3.4
2.46
2.07
mmol/l
0.88
234
1562
52
223
2.36
7.64
1.8
1.4
28896.79
85954.03
e6/l
0.85
29
122
57
255
2.27
7.61
1.8
1.4
1637.49
1654.79
e6/l
0.02
39
183
757
6302
1.30
7.59
3.2
3.0
6.52
6.63
mmol/l
0.33
614
5216
255
1783
1.48
7.56
2.1
2.7
63.92
66.39
g/l
5.63
225
1603
95
518
1.87
7.45
3.3
3.3
0.85
0.81
nmol/l
0.28
78
405
634
5167
1.31
7.42
1.6
1.6
19.92
21.36
nmol/l
1.66
556
4311
261
1844
1.47
7.34
4.0
3.4
5.95
5.82
kpa
0.99
255
1795
243
1694
1.48
7.31
7.1
6.7
10.82
10.01
mmol/l
0.78
228
1615
744
6210
1.29
7.24
3.3
3.1
29.65
35.10
u/l
1.64
706
5871
770
6456
1.29
7.23
2.5
2.5
59.01
71.80
u/l
0.50
723
5913
732
6103
1.29
7.17
3.3
3.1
331.65
358.64
mg/l
0.06
471
3608
2025
19184
1.39
7.12
4.9
4.6
4.59
4.73
mmol/l
7.67
1883
17452
1948
18345
1.35
7.09
4.2
4.1
1.28
1.28
mmol/l
0.19
1776
16404
551
4430
1.32
7.07
1.9
1.7
1.29
1.25
mg/l
0.14
435
3426
925
7964
1.27
6.93
4.2
3.8
105.07
96.31
ng/l
0.04
651
5682
139
866
1.64
6.88
1.7
2.3
3.62
3.56
g/l
0.19
119
774
131
804
1.67
6.87
1.6
2.3
9.43
10.24
g/l
1.39
110
705
139
867
1.64
6.85
1.7
2.3
—
—
—
0
0
139
867
1.64
6.85
1.7
2.3
7.58
7.52
g/l
0.14
118
774
1209
10754
1.25
6.79
2.8
2.7
—
—
—
0
0
35
132
2.68
6.74
1.5
1.5
11.66
13.41
u/l
1.01
35
123
35
132
2.68
6.74
1.2
1.1
388.57
105.91
titre
—
7
22
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
111
660
1.72
6.56
2.3
2.7
0.38
0.37
u/ml
0.09
64
386
2005
19027
1.36
6.44
4.8
4.6
1.49
1.55
mmol/l
8.11
1840
17195
75
398
1.91
6.43
1.6
1.6
250.36
325.62
mu/l
2.35
70
359
221
1552
1.47
6.42
1.6
1.6
—
—
—
0
0
609
5032
1.28
6.26
2.8
2.5
4389.21
5709.47
umol/l
0.31
515
4308
185
1264
1.50
6.16
7.6
7.6
92.97
93.82
%
0.66
185
1257
22
68
3.26
6.00
1.4
1.5
0.37
0.45
ug/l
0.35
14
38
32
124
2.60
5.88
1.2
1.2
33.96
16.97
u/l
0.59
26
106
48
224
2.17
5.86
1.2
1.2
72.27
56.17
u/l
0.91
41
204
181
1251
1.48
5.71
7.8
7.6
0.63
0.69
%
1.22
181
1241
288
2171
1.37
5.62
3.5
3.4
—
—
—
0
0
141
932
1.55
5.50
1.5
1.7
1.70
1.58
g/l
0.95
121
801
66
355
1.88
5.49
1.2
1.2
—
—
—
0
0
1110
9932
1.22
5.40
5.9
5.5
0.00
0.00
estimate
0.50
214
1787
93
559
1.69
5.34
1.7
1.6
—
—
—
0
0
1106
9915
1.22
5.22
4.2
4.1
0.00
0.00
estimate
0.99
224
1965
31
127
2.46
5.13
1.2
1.2
95.15
73.21
u/l
0.39
26
111
304
2347
1.34
5.08
2.4
2.5
1.86
1.84
%
0.10
271
2056
642
5459
1.24
5.01
1.7
1.6
1.37
1.34
mmol/l
0.30
517
4565
1117
10053
1.21
4.98
4.3
4.1
0.00
0.01
estimate
0.00
201
1791
41
195
2.12
4.83
1.3
1.2
—
—
—
0
0
206
2752
0.72
4.65
8.7
7.2
—
—
—
0
0
49
254
1.95
4.60
1.3
1.3
341.27
321.07
pmol/l
0.12
43
214
15
37
4.07
4.40
2.6
1.4
104.41
89.21
ng/l
0.20
15
37
1312
12072
1.20
4.37
3.3
3.1
45.14
48.46
u/l
0.76
1236
11007
51
276
1.87
4.24
1.3
1.2
17.85
14.56
u/l
0.65
44
217
726
6425
1.19
3.57
2.1
2.1
172.76
203.62
u/l
0.49
683
5970
207
1599
1.32
3.48
3.6
3.2
0.65
0.79
ug/l
2.37
155
1091
294
2405
1.25
3.18
3.2
3.9
4.32
17.57
ug/l
3.00
241
1945
111
796
1.41
3.01
1.9
1.8
—
—
—
0
0
26
127
2.06
2.97
1.5
1.6
—
—
—
0
0
16
65
2.47
2.79
2.0
1.5
80.25
91.02
nmol/24h
0.17
16
65
220
1768
1.27
2.78
2.3
2.5
72.42
70.36
e9/l
0.38
160
1339
15
59
2.55
2.78
1.1
1.2
118.00
113.94
%
0.32
15
50
93
660
1.43
2.70
2.5
2.8
—
—
—
0
0
8
19
4.22
2.68
9.0
16.2
4.71
5.44
mmol/l
—
8
19
63
415
1.53
2.65
1.6
1.6
—
—
—
0
0
482
4226
1.18
2.57
1.7
1.8
1133.34
1188.89
nmol/l
0.62
385
3098
14
56
2.51
2.53
1.2
1.3
23.73
500.09
ug/l
—
6
33
155
1208
1.30
2.51
1.5
1.5
—
—
—
0
0
275
2294
1.22
2.51
1.9
2.0
144.03
136.04
ug/g
0.12
223
1763
116
867
1.36
2.51
1.9
1.9
—
—
—
0
0
241
1988
1.24
2.45
2.1
2.1
0.21
0.21
g/l
0.27
225
1855
109
811
1.36
2.43
3.1
3.2
271.28
2032.21
u/ml
0.78
91
679
332
2831
1.20
2.43
1.5
1.4
—
—
—
0
0
522
4644
1.16
2.30
1.8
1.7
53241167.55
27549020.79
pmol/l
0.37
432
3757
90
658
1.38
2.26
1.3
1.3
—
—
—
0
0
7
18
3.90
2.25
2.3
1.3
—
—
—
0
0
81
583
1.40
2.23
1.5
1.7
—
—
—
0
0
41
257
1.61
2.18
1.7
1.5
46.56
58.72
%
0.92
27
165
41
636
0.64
2.18
1.4
1.4
—
—
—
0
0
19
95
2.01
2.10
1.3
1.4
6.01
5.96
mmol/l
0.04
19
89
227
2701
0.82
2.08
4.7
4.7
33.33
33.54
%
0.11
169
1727
77
558
1.39
2.06
2.0
2.1
10.02
11.08
nmol/l
0.48
68
483
149
1190
1.27
2.05
1.2
1.3
70.86
50.34
au/ml
—
7
77
83
610
1.37
2.05
1.4
1.6
1.14
1.18
g/l
0.58
77
578
9
32
2.82
2.00
1.4
1.4
—
—
—
0
0
70
505
1.40
1.94
1.9
1.6
12824.61
13381.51
e6/l
0.05
51
368
5
11
4.55
1.94
1.2
1.0
—
—
—
0
0
75
548
1.38
1.93
1.5
1.3
—
—
—
0
0
80
591
1.37
1.93
1.3
1.6
0.23
0.23
g/l
0.09
74
560
162
1322
1.24
1.87
2.2
2.4
32.06
26.29
au/ml
—
8
87
262
2244
1.19
1.86
4.6
4.5
21.06
21.49
%
0.18
128
1121
11
46
2.40
1.85
1.1
1.2
120.32
135.37
pmol/l
0.18
11
46
65
468
1.40
1.84
2.4
3.1
1.80
1.59
mg/l
1.05
59
429
135
1082
1.26
1.83
1.7
1.8
—
—
—
0
0
63
452
1.40
1.82
1.2
1.6
—
—
—
0
0
123
976
1.27
1.81
1.0
1.0
—
—
—
0
0
93
711
1.32
1.81
2.2
2.2
289.94
735.94
ug/l
0.87
82
666
140
1130
1.25
1.79
1.5
1.8
1.22
1.44
g/l
0.83
131
1019
217
1834
1.20
1.79
2.6
2.4
5.06
6.20
ug/l
0.58
192
1559
61
437
1.41
1.78
2.0
2.1
131.30
126.62
g/l
0.76
40
307
7
24
2.92
1.72
2.6
2.7
1.29
0.67
u/field
—
7
24
7
24
2.92
1.72
1.0
1.7
—
—
—
0
0
320
2806
1.16
1.72
5.7
5.2
3.60
3.31
ug/l
0.11
274
2450
24
140
1.72
1.72
1.7
1.6
2.53
7.23
u/l
2.13
17
116
32
202
1.59
1.71
1.3
1.4
48.54
33.46
u/l
1.08
27
166
63
459
1.38
1.68
1.4
1.3
—
—
—
0
0
198
1673
1.20
1.66
1.7
1.7
1.49
1.45
%
0.39
166
1432
17
90
1.90
1.65
1.1
1.1
—
—
—
0
0
119
957
1.26
1.60
1.6
1.7
—
—
—
0
0
23
136
1.70
1.59
1.2
1.2
—
—
titre
—
0
0
79
605
1.32
1.56
1.2
1.2
—
—
—
0
0
805
7522
1.11
1.55
4.5
4.4
—
—
—
0
0
23
137
1.69
1.55
1.0
1.0
298.26
292.84
mg/l
0.15
23
116
14
71
1.98
1.54
1.1
3.1
57.67
176.80
umol/l
—
6
45
78
600
1.31
1.50
1.2
1.2
—
—
—
0
0
169
1429
1.20
1.43
2.9
3.7
104.76
65.09
u/ml
0.22
164
1377
9
39
2.31
1.43
1.1
1.2
—
—
—
0
0
17
97
1.76
1.35
1.9
1.3
5.71
4.85
%
—
7
20
82
646
1.28
1.35
1.3
1.5
297.07
284.08
ug/g
0.20
43
366
0
39
0.00
1.33
0.0
1.2
—
—
—
0
0
29
192
1.52
1.32
1.8
1.5
26.84
34.68
%
0.47
19
122
25
161
1.56
1.28
2.0
1.9
—
—
—
0
0
58
439
1.33
1.28
1.2
1.2
—
—
—
0
0
80
634
1.27
1.27
1.4
1.3
39.21
33.90
iu/l
0.66
73
541
371
3363
1.12
1.25
1.3
1.2
12.09
13.40
u/ml
0.12
126
1244
18
108
1.67
1.22
2.1
1.8
1.50
2.69
u/field
0.60
12
76
14
78
1.80
1.21
1.2
1.2
131.50
147.96
mmol/24h
0.33
14
78
37
263
1.41
1.21
1.3
1.3
111.29
111.77
u/ml
—
7
54
22
140
1.58
1.20
1.1
1.2
—
—
—
0
0
8
39
2.05
1.15
1.4
1.2
—
—
—
0
0
5
20
2.50
1.15
1.2
1.4
—
—
—
0
0
15
87
1.73
1.15
1.1
1.1
—
—
—
0
0
58
449
1.30
1.12
2.1
2.3
43.56
100.12
ug/min
1.71
35
259
112
936
1.21
1.12
2.9
2.4
0.64
0.65
%
0.18
112
930
16
96
1.67
1.10
1.4
1.3
—
—
—
0
0
16
96
1.67
1.10
1.4
1.3
—
—
—
0
0
16
96
1.67
1.10
1.2
1.9
0.23
0.19
e9/l
0.29
11
85
114
957
1.20
1.10
2.8
2.4
1.20
1.12
%
0.42
114
951
58
451
1.29
1.09
1.2
1.1
—
—
—
0
0
20
128
1.57
1.08
1.4
1.3
—
—
—
0
0
47
356
1.33
1.07
2.4
1.8
1.04
0.81
nmol/l
0.98
40
288
20
129
1.56
1.05
1.4
1.3
—
—
—
0
0
30
212
1.42
1.04
3.3
3.6
—
—
—
0
0
5
22
2.28
1.03
1.2
1.0
—
—
—
0
0
43
324
1.33
1.02
5.5
4.6
295.71
310.95
iu/ml
—
7
42
31
223
1.40
0.98
1.3
1.3
277.85
275.11
mosm/kgh2o
0.33
26
166
73
594
1.24
0.98
1.9
1.7
—
—
—
0
0
27
190
1.43
0.97
1.4
1.7
47.44
44.20
nmol/l
0.21
27
180
163
1429
1.15
0.96
2.3
2.7
9.75
10.44
g/l
1.42
148
1290
99
834
1.20
0.95
1.8
1.9
35.96
39.46
u/l
1.07
87
734
382
3526
1.10
0.95
1.3
1.3
32.05
36.96
iu/ml
0.31
110
1133
142
1235
1.16
0.94
3.9
3.8
5.33
5.20
kpa
0.87
136
1169
137
1193
1.16
0.90
1.3
1.2
150.25
182.83
u/ml
0.33
124
1086
25
178
1.41
0.86
1.0
1.1
—
—
—
0
0
134
1171
1.15
0.85
3.8
3.7
2.63
2.05
mmol/l
0.84
110
877
34
256
1.33
0.85
1.0
1.1
—
—
—
0
0
8
45
1.78
0.84
1.1
1.1
—
—
—
0
0
26
188
1.39
0.83
2.2
2.3
3.08
2.18
u/field
0.38
13
65
6
32
1.88
0.81
1.5
1.3
28.33
1180.05
u/l
—
6
21
63
517
1.22
0.81
1.4
1.5
—
—
—
0
0
49
393
1.25
0.78
1.6
2.7
28.25
34.18
umol/l
0.97
38
349
31
234
1.33
0.77
1.1
1.1
1.75
2.17
u/ml
0.21
12
84
6
34
1.77
0.76
1.0
1.2
—
—
—
0
0
146
1296
1.13
0.76
6.5
7.0
25.10
24.63
mmol/l
1.04
141
1229
18
125
1.44
0.72
1.6
1.5
80.28
79.65
umol/l
0.04
18
125
27
202
1.34
0.72
1.5
1.4
—
—
—
0
0
15
101
1.49
0.70
1.2
1.9
473.80
439.79
e6/l
—
10
86
17
118
1.44
0.69
1.3
1.4
—
—
—
0
0
17
118
1.44
0.69
1.3
1.4
—
—
—
0
0
113
994
1.14
0.69
4.5
3.2
26.17
25.52
mmol/l
1.63
108
968
33
420
0.78
0.69
1.3
1.3
163.30
218.00
miu/ml
0.56
14
190
37
293
1.27
0.68
1.1
1.2
—
—
—
0
0
5
28
1.79
0.66
1.2
1.0
—
—
—
0
0
393
3703
1.07
0.63
1.5
1.4
—
—
—
0
0
25
190
1.32
0.62
1.5
1.6
—
—
—
0
0
5
30
1.67
0.61
1.0
1.2
2.03
1.62
umol/24h
—
5
30
0
20
0.00
0.60
0.0
1.1
—
0.44
—
0
14
0
20
0.00
0.60
0.0
1.0
—
—
—
0
0
31
245
1.27
0.59
1.7
1.6
—
—
—
0
0
32
254
1.26
0.59
1.1
1.1
—
—
—
0
0
8
52
1.54
0.59
2.5
2.9
—
—
—
0
0
8
52
1.54
0.59
2.5
2.9
—
—
—
0
0
34
273
1.25
0.58
1.2
1.2
301.40
272.38
u/ml
0.28
25
160
8
54
1.48
0.57
1.4
1.4
24.75
23.02
%
—
8
42
28
220
1.28
0.57
1.6
1.5
—
—
—
0
0
32
256
1.25
0.56
1.2
1.2
8.00
2.78
u/ml
0.46
11
68
14
98
1.43
0.56
1.0
1.0
—
—
—
0
0
14
98
1.43
0.56
1.0
1.1
—
—
—
0
0
57
485
1.18
0.56
1.8
1.8
—
—
—
0
0
9
60
1.50
0.54
1.1
1.2
—
—
—
0
0
47
395
1.19
0.54
3.4
3.6
60.57
57.18
%
1.31
47
395
17
125
1.36
0.53
1.2
1.2
9.47
9.13
mmol/l
0.10
17
118
87
769
1.14
0.53
4.4
4.1
25.65
25.09
mmol/l
0.83
82
701
11
74
1.49
0.53
3.0
1.8
—
—
—
0
0
25
315
0.79
0.52
1.3
1.4
—
—
—
0
0
25
315
0.79
0.52
1.3
1.4
—
—
—
0
0
146
1595
0.91
0.51
2.4
2.6
58.50
63.09
ml/min/173m2
1.02
70
667
33
269
1.23
0.51
1.8
1.5
—
—
—
0
0
6
41
1.46
0.50
1.7
1.2
1.47
117.47
mg/l
—
6
30
101
908
1.12
0.49
1.3
1.3
—
—
—
0
0
35
421
0.83
0.48
1.4
1.5
294.39
1034.69
e6/l
1.17
28
338
21
163
1.29
0.48
1.1
1.6
—
—
—
0
0
7
46
1.52
0.48
1.1
1.2
—
—
—
0
0
26
208
1.25
0.48
1.5
1.4
—
—
—
0
0
26
208
1.25
0.48
1.5
1.4
—
—
—
0
0
35
420
0.83
0.48
1.3
1.4
162.40
23.43
e6/l
0.40
25
318
26
209
1.25
0.46
1.3
1.3
201591.75
122631.21
e6/l
0.20
20
141
26
209
1.25
0.46
1.5
1.4
—
—
—
0
0
26
209
1.25
0.46
1.5
1.4
—
—
—
0
0
19
147
1.29
0.45
1.0
1.3
—
—
—
0
0
550
5298
1.05
0.45
4.5
4.5
0.00
0.00
estimate
1.08
211
1761
83
744
1.12
0.43
4.2
3.5
1.46
1.38
mmol/l
0.33
83
728
18
139
1.30
0.43
1.4
1.3
2.52
2.14
mmol/l
0.61
18
133
9
128
0.70
0.43
1.1
1.4
1.23
1.09
promille
—
9
96
13
174
0.75
0.43
1.1
1.4
—
—
—
0
0
13
174
0.75
0.43
1.1
1.4
—
—
—
0
0
13
174
0.75
0.43
1.1
1.4
—
—
—
0
0
11
151
0.73
0.42
1.5
1.4
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
15
113
1.33
0.42
1.1
1.1
—
—
—
0
0
5
32
1.56
0.42
1.0
1.3
—
—
—
0
0
22
176
1.25
0.41
1.0
1.2
88.64
95.78
%
0.69
22
165
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
18
141
1.28
0.40
1.7
1.2
0.51
1.21
u/ml
0.40
12
72
0
18
0.00
0.40
0.0
1.3
—
9.28
—
0
18
48
418
1.15
0.39
2.3
2.4
17.13
15.85
%
1.11
23
201
27
223
1.21
0.39
1.3
1.6
—
—
—
0
0
57
503
1.14
0.39
1.1
1.1
5.81
6.60
u/ml
—
7
44
0
19
0.00
0.39
0.0
4.8
—
—
—
0
0
32
270
1.19
0.38
1.3
1.4
—
—
—
0
0
27
224
1.21
0.38
1.0
1.0
1.29
3.03
u/ml
0.97
13
101
5
36
1.39
0.38
1.0
1.0
—
—
—
0
0
13
170
0.76
0.38
1.6
1.5
—
—
—
0
0
30
252
1.19
0.38
1.2
1.2
3.75
5.49
u/ml
0.43
16
98
64
574
1.12
0.35
1.5
1.5
0.01
10.01
iu/ml
0.51
16
122
6
42
1.43
0.35
1.0
1.2
—
—
—
0
0
17
135
1.26
0.35
1.8
2.0
6.51
7.39
umol/l
0.15
17
87
21
255
0.82
0.35
1.2
1.4
—
—
—
0
0
30
255
1.18
0.34
1.1
1.1
0.37
1.46
u/ml
1.77
13
125
451
4358
1.04
0.34
5.0
4.6
1.02
1.02
kg/l
0.22
87
668
17
209
0.81
0.32
1.4
1.3
—
—
—
0
0
17
209
0.81
0.32
1.4
1.3
—
—
—
0
0
57
512
1.12
0.32
1.1
1.2
1.68
3.22
u/ml
—
5
56
58
522
1.11
0.31
1.1
1.2
3.51
6.12
u/ml
—
9
104
7
53
1.32
0.30
1.0
1.2
—
—
—
0
0
43
483
0.89
0.29
1.3
1.3
666.72
520.74
mg/l
1.04
43
455
8
106
0.75
0.29
1.0
1.4
—
—
—
0
0
8
106
0.75
0.29
1.0
1.4
—
—
—
0
0
13
103
1.26
0.28
1.0
1.2
—
—
—
0
0
50
451
1.11
0.27
2.1
3.2
201.64
956.58
u/ml
0.66
43
408
9
120
0.75
0.27
1.2
1.1
—
—
—
0
0
44
488
0.90
0.25
4.3
3.1
7.86
7.66
mmol/l
0.28
44
480
9
74
1.22
0.25
1.9
2.1
19.91
121.25
ug/l
—
9
67
9
74
1.22
0.25
1.1
1.2
—
—
—
0
0
18
151
1.19
0.25
1.1
1.0
—
—
—
0
0
5
38
1.32
0.23
1.0
1.3
—
—
—
0
0
13
106
1.23
0.23
3.2
2.2
—
169.42
—
0
19
12
97
1.24
0.23
1.3
1.7
—
—
—
0
0
13
107
1.22
0.21
1.0
1.1
—
—
—
0
0
19
163
1.17
0.21
1.0
1.1
—
2.38
—
0
13
0
10
0.00
0.21
0.0
13.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
20
173
1.16
0.21
1.1
1.1
—
65.33
—
0
9
0
13
0.00
0.21
0.0
1.2
—
22.62
—
0
5
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
0.02
—
0
9
0
14
0.00
0.20
0.0
1.0
—
20.71
—
0
14
0
14
0.00
0.20
0.0
1.0
—
7.66
—
0
14
0
14
0.00
0.20
0.0
1.0
—
37.36
—
0
14
9
114
0.79
0.20
1.1
1.5
—
—
—
0
0
37
336
1.10
0.19
1.9
1.9
4706.91
3599.70
u/l
0.15
16
137
15
175
0.86
0.18
1.2
1.2
—
—
—
0
0
24
269
0.89
0.18
5.6
4.9
392.05
364.32
umol/l
0.48
19
232
7
58
1.21
0.18
1.1
1.2
—
—
—
0
0
7
61
1.15
0.17
1.1
1.1
1263.57
1803.59
miu/ml
—
7
61
5
69
0.72
0.17
1.0
1.0
—
—
—
0
0
12
141
0.85
0.16
1.5
1.7
—
—
—
0
0
45
484
0.93
0.16
1.3
1.4
—
—
—
0
0
18
204
0.88
0.16
2.3
3.0
—
—
—
0
0
26
287
0.90
0.16
1.3
1.4
—
—
—
0
0
26
287
0.90
0.16
1.3
1.4
—
—
—
0
0
17
193
0.88
0.15
1.2
1.5
—
—
—
0
0
9
79
1.14
0.15
2.2
2.7
789.56
1153.33
u/ml
—
9
79
9
82
1.10
0.15
1.2
1.2
—
—
—
0
0
7
87
0.80
0.14
1.0
1.4
—
—
—
0
0
7
87
0.80
0.14
1.0
1.4
—
—
—
0
0
7
88
0.79
0.14
1.0
1.4
—
—
—
0
0
27
295
0.91
0.14
1.1
1.4
—
—
—
0
0
8
96
0.83
0.13
1.0
1.3
—
—
—
0
0
11
94
1.17
0.13
2.0
2.8
45.37
43.82
%
—
6
60
125
1208
1.04
0.13
1.9
1.7
—
—
—
0
0
30
277
1.08
0.12
1.0
1.1
400.38
103.04
iu/ml
—
5
58
18
162
1.11
0.11
1.0
1.1
—
—
—
0
0
22
240
0.92
0.11
1.5
1.5
—
—
—
0
0
14
156
0.90
0.10
1.9
1.7
5.24
4.05
mg/l
0.33
14
148
19
207
0.92
0.09
1.2
1.4
—
—
—
0
0
26
242
1.08
0.09
1.0
1.1
—
—
—
0
0
35
330
1.06
0.09
1.7
1.8
1.69
1.63
mmol/l
0.15
35
318
13
145
0.90
0.09
1.3
1.2
—
—
—
0
0
13
145
0.90
0.09
1.3
1.2
—
—
—
0
0
13
145
0.90
0.09
1.3
1.2
—
—
—
0
0
13
145
0.90
0.09
1.3
1.2
—
—
—
0
0
76
787
0.96
0.09
1.9
2.0
0.66
2.21
ug/l
2.40
62
682
25
233
1.07
0.09
1.1
1.2
118.36
119.61
%
0.07
25
210
27
288
0.94
0.08
1.3
1.4
—
—
—
0
0
45
471
0.95
0.08
1.2
1.5
—
—
—
0
0
6
58
1.03
0.08
1.7
1.5
7.13
9.16
ug/l
—
6
58
6
58
1.03
0.08
1.0
1.1
—
—
—
0
0
13
144
0.90
0.08
1.3
1.2
—
—
—
0
0
5
61
0.82
0.08
1.2
1.1
—
—
—
0
0
5
61
0.82
0.08
1.2
1.1
—
—
—
0
0
7
64
1.09
0.08
1.1
1.1
—
—
—
0
0
7
66
1.06
0.08
1.0
1.1
—
—
—
0
0
28
297
0.94
0.08
1.3
1.4
—
—
—
0
0
6
71
0.84
0.07
1.7
1.2
—
—
—
0
0
63
610
1.03
0.07
1.9
1.7
—
—
—
0
0
45
468
0.96
0.07
4.6
3.7
23.18
25.95
mg/l
0.21
27
295
8
92
0.87
0.06
4.0
4.3
—
—
—
0
0
13
119
1.09
0.06
1.2
1.2
—
—
—
0
0
28
294
0.95
0.06
1.3
1.4
—
—
—
0
0
25
237
1.06
0.05
7.0
6.3
12.53
12.15
mg/l
0.17
25
219
10
90
1.11
0.05
1.4
1.4
1.57
1.63
g/l
—
10
90
28
267
1.05
0.05
1.4
1.5
—
—
—
0
0
34
354
0.96
0.05
1.3
1.5
—
—
—
0
0
59
606
0.97
0.05
1.4
1.7
3.51
4.04
mg/l
0.18
45
457
10
110
0.91
0.05
2.1
2.5
—
—
—
0
0
65
634
1.03
0.05
4.6
3.6
3.86
3.84
mmol/l
0.14
65
627
62
605
1.03
0.04
1.4
1.5
133.61
234.72
pmol/l
1.28
62
589
28
292
0.96
0.04
1.3
1.4
—
—
—
0
0
50
514
0.97
0.04
3.9
3.0
1.83
1.55
mmol/l
0.70
50
505
12
111
1.08
0.04
1.2
1.6
—
—
—
0
0
13
121
1.07
0.03
1.2
1.2
—
—
—
0
0
45
462
0.97
0.03
1.2
1.5
—
—
—
0
0
73
743
0.98
0.03
1.3
1.4
—
—
—
0
0
11
102
1.08
0.03
6.4
3.0
—
—
—
0
0
13
122
1.07
0.02
1.4
1.8
—
—
—
0
0
27
279
0.97
0.02
1.1
1.1
—
—
—
0
0
33
339
0.97
0.02
1.2
1.4
—
—
—
0
0
19
198
0.96
0.02
1.0
1.1
—
4.44
—
0
5
10
93
1.08
0.02
1.0
1.2
159.80
341.81
u/l
—
10
83
10
93
1.08
0.02
1.0
1.4
—
—
—
0
0
36
352
1.02
0.01
1.6
1.5
—
—
—
0
0
14
133
1.05
0.01
1.4
1.8
—
—
—
0
0
10
101
0.99
0.00
1.3
1.1
—
—
—
0
0
11
109
1.01
0.00
1.3
1.6
—
—
—
0
0
11
109
1.01
0.00
1.3
1.1
1.03
1.11
u/l
—
6
60
20
195
1.03
0.00
1.4
1.4
0.33
0.27
nmol/l
—
9
146
17
171
0.99
0.00
1.0
1.1
—
—
—
0
0
27
274
0.99
0.00
1.7
1.9
88.79
89.51
%
0.25
27
267
43
426
1.01
0.00
1.1
1.2
—
10.84
—
0
5
17
172
0.99
0.00
2.8
2.3
—
—
—
0
0
31
313
0.99
0.00
1.2
1.3
—
—
—
0
0
13
127
1.02
0.00
1.2
1.5
—
—
—
0
0
23
227
1.01
0.00
1.0
1.1
—
—
—
0
0
19
193
0.98
0.00
1.1
1.0
0.51
0.95
u/ml
0.69
12
94
6
65
0.92
0.00
1.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
2.56
—
0
9
5
51
0.98
-0.00
1.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
1.98
—
0
5
29
290
1.00
-0.00
1.4
2.3
18.50
26.85
mg/l
—
8
76
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
88
0.91
-0.00
1.4
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
7
77
0.91
-0.00
1.1
1.1
—
13.40
—
0
10
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYTOXGOITMULT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYTOXGOITMULT | 1.258 [1.14, 1.39] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.248 |
During the follow-up period (1.1.1998 — 31.12.2019), 1886 out of 8353 females with E4_THYTOXGOITMULT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYTOXGOITMULT | 1.226 [1.04, 1.45] | 0.016 |
| Birth year | 0.988 [0.98, 1.0] | 0.014 |
During the follow-up period (1.1.1998 — 31.12.2019), 410 out of 1483 males with E4_THYTOXGOITMULT died.
Mortality risk
Mortality risk for people of age
years, who have E4_THYTOXGOITMULT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.142% | 0.251% |
| 5 | 0.77% | 1.437% |
| 10 | 1.909% | 3.544% |
| 15 | 3.56% | 6.687% |
| 20 | 6.338% | 11.5% |
Relationships between endpoints
↥Index endpoint: E4_THYTOXGOITMULT – Thyrotoxicosis with toxic multinodular goitre
GWS hits: 24
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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