Disorder of external ear, unspecified

H8_EXTDISINOTH

auditory system disease: Pathological processes of the ear, the hearing, and the equilibrium system of the body.

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Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H62*
  • Cause of death: ICD-10 H62*

2 out of 7 registries used, show all original rules.

1264

4. Check minimum number of events

None

1264

5. Include endpoints

None

1264

6. Filter based on genotype QC (FinnGen only)

1233

Control definitions (FinnGen only)

Control exclude
H8_EXTERNAL

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7369 3573 3766
Only index persons 7023 3453 3570
Unadjusted period prevalence (%)
Whole population 0.10 0.10 0.11
Only index persons 0.13 0.13 0.14
Median age at first event (years)
Whole population 57.40 57.69 57.22
Only index persons 57.52 57.75 57.29

-FinnGen-

Key figures

All Female Male
Number of individuals 1233 662 571
Unadjusted period prevalence (%) 0.25 0.23 0.26
Median age at first event (years) 58.84 56.71 61.31

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1264
Matched controls
12640
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H60.9
ICD-10 Finland
Otitis externa, unspecified
13.4
313.3
337
335
A46
ICD-10 Finland
Erysipelas
10.9
307.7
622
1030
H62.0*A46
ICD-10 Finland
Otitis externa in erysipelas
3308.8
307.7
959
12
H60.3
ICD-10 Finland
Other infective otitis externa
28.6
198.9
136
53
H60.8
ICD-10 Finland
Other otitis externa
18.3
185.6
154
95
H62.0
ICD-10 Finland
Otitis externa in bacterial diseases classified elsewhere
628.9
170.5
165
*
H60.1
ICD-10 Finland
Cellulitis of external ear
32.0
157.1
103
35
H60
ICD-10 Finland
Otitis externa
7.0
101.6
167
269
H62.1*B02.8
ICD-10 Finland
Otitis externa in zoster
+∞
97.2
92
*
S76
ICPC
Skin infection other
5.6
75.5
155
308
H01
ICPC
Ear pain/earache
4.1
75.3
244
702
H70
ICPC
Otitis externa
10.2
71.4
82
85
H29
ICPC
Ear symptom/complaint other
3.9
69.5
240
720
J01DB01
ATC
cefalexin; oral
5.7
63.6
1181
9010
J01CE08
ATC
benzathine benzylpenicillin; parenteral
13.9
54.7
51
38
H04
ICPC
Ear discharge
5.5
44.5
90
175
UDC00
NOMESCO Finland
Ear microscopy
3.7
43.8
151
446
B02.8
ICD-10 Finland
Zoster with other complications
17.1
42.0
35
21
H62.2
ICD-10 Finland
Otitis externa in mycoses
420.8
41.4
41
*
D07AB02
ATC
hydrocortisone butyrate; topical
2.3
40.9
454
2479
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
8.2
40.7
55
70
J01FF01
ATC
clindamycin; systemic
2.3
40.1
431
2317
H62.2*B44.8
ICD-10 Finland
Otitis externa in aspergillosis
+∞
36.6
35
*
D07AC01
ATC
betamethasone; topical
2.1
35.9
520
3123
H66.9
ICD-10 Finland
Otitis media, unspecified
3.9
35.5
112
310
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.7
35.1
221
924
H62.2*B36.9
ICD-10 Finland
Otomycosis NOS
335.5
33.0
33
*
H62.1*B00.19
ICD-10 Finland
Otitis externa in herpesviral [herpes simplex] infection
+∞
30.3
29
*
H66.0
ICD-10 Finland
Acute suppurative otitis media
3.3
30.3
121
391
D07XC01
ATC
betamethasone; topical
2.6
29.9
197
838
S02CA02
ATC
flumetasone and antiinfectives; otic
3.5
28.4
102
308
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
28.0
619
4211
G51.0
ICD-10 Finland
Bell palsy
5.1
27.9
60
123
J01DA01
ATC
[U] cefalexin
1.9
25.9
818
6183
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.1
25.0
281
1498
H61.2
ICD-10 Finland
Impacted cerumen
3.3
24.7
98
315
E0000UV, ,
ATC
1.9
24.4
547
3688
SPAT1255
SPAT
Intravenous administration of medicine
2.9
24.1
118
429
S29
ICPC
Skin symptom/complaint other
2.1
23.0
259
1378
S03CA04
ATC
hydrocortisone and antiinfectives; ophthalmic, otic
4.5
21.9
54
124
H62.2*B37.2
ICD-10 Finland
Otitis externa in candidiasis
223.7
21.7
22
*
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.5
21.3
146
629
D07AA02
ATC
hydrocortisone; topical
2.2
20.7
198
985
J01CE02
ATC
phenoxymethylpenicillin; oral
1.8
19.6
880
7089
TDA90
NOMESCO Finland
Removal wax from ear
6.2
19.4
33
54
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.9
19.4
308
1838
H60.0
ICD-10 Finland
Abscess of external ear
26.5
19.2
26
10
D07AC13
ATC
mometasone; topical
1.8
19.1
385
2473
S03CA01
ATC
dexamethasone and antiinfectives; ophthalmic, otic
4.6
19.0
45
100
J05AB11
ATC
valaciclovir; oral
2.1
18.8
208
1093
H61.0
ICD-10 Finland
Perichondritis of external ear
192.7
18.6
19
*
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.7
18.0
666
5036
H60.5
ICD-10 Finland
Acute otitis externa, noninfective
13.9
17.8
30
22
D07BC01
ATC
betamethasone and antiseptics; topical
2.2
17.5
169
841
H65.0
ICD-10 Finland
Acute serous otitis media
5.6
17.5
33
60
D07CC01
ATC
betamethasone and antibiotics; topical
2.1
17.1
181
933
R50.9
ICD-10 Finland
Fever, unspecified
2.0
17.1
202
1085
J01MA02
ATC
ciprofloxacin; systemic
1.7
17.0
486
3416
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.9
16.6
231
1312
L40.0
ICD-10 Finland
Psoriasis vulgaris
3.1
16.6
69
228
E000001, ,
ATC
1.9
16.0
251
1483
Z3229
NOMESCO Finland
Other healthcare associate professional
2.4
15.8
115
508
L08.9
ICD-10 Finland
Local infection of skin and subcutaneous tissue, unspecified
3.5
15.8
54
158
Z3231
NOMESCO Finland
Registered nurse
1.7
15.5
344
2249
H92.0
ICD-10 Finland
Otalgia
2.7
15.1
84
326
D07AD01
ATC
clobetasol; topical
1.9
15.1
217
1244
AA1AD
NOMESCO Finland
CT of head and brain
1.7
15.1
338
2213
D07AB08
ATC
desonide; topical
2.1
15.0
147
735
H81
ICPC
Excessive ear wax
1.9
15.0
213
1216
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
5.1
14.8
31
62
N02BE01
ATC
paracetamol; systemic, rectal
2.0
14.6
1120
10016
S01
ICPC
Pain/tenderness of skin
2.9
14.6
69
246
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.0
14.2
176
958
SPAT1263
SPAT
Sampling
1.6
14.0
512
3782
H13
ICPC
Plugged feeling ear
1.8
13.9
232
1390
H62.4*L01.0
ICD-10 Finland
Otitis externa in impetigo
+∞
13.6
13
*
D05AX02
ATC
calcipotriol; topical
3.0
13.5
59
201
D06AX01
ATC
fusidic acid; topical
2.1
13.2
128
636
L20.0
ICD-10 Finland
Besnier prurigo
2.4
13.1
95
419
H02AB06
ATC
prednisolone; systemic
1.6
13.1
576
4419
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
16.9
13.0
20
12
L03.2
ICD-10 Finland
Cellulitis of face
9.5
13.0
26
28
B02.9
ICD-10 Finland
Zoster without complication
2.4
12.9
91
397
G47.3
ICD-10 Finland
Sleep apnoea
1.7
12.8
300
1975
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
12.8
430
3097
D05AX52
ATC
calcipotriol, combinations; topical
2.6
12.6
76
308
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.9
12.3
165
921
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
12.2
268
1732
J01CF05
ATC
flucloxacillin; systemic
2.3
12.2
91
407
R06AE07
ATC
cetirizine; oral
1.5
12.1
521
3957
S06
ICPC
Rash localized
2.6
12.1
73
296
D11AH01
ATC
tacrolimus; topical
8.8
12.0
25
29
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.8
12.0
205
1234
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.9
12.0
167
944
Z71.8
ICD-10 Finland
Other specified counselling
1.6
12.0
365
2562
H65.3
ICD-10 Finland
Chronic mucoid otitis media
4.5
11.9
29
66
N03AX09
ATC
lamotrigine; oral
2.6
11.8
69
275
Z2221
NOMESCO Finland
Medical doctor
1.6
11.8
331
2276
J01CA04
ATC
amoxicillin; systemic
1.7
11.8
999
8783
R42
ICD-10 Finland
Dizziness and giddiness
1.7
11.7
268
1751
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.9
11.6
163
924
H61.8
ICD-10 Finland
Other specified disorders of external ear
11.9
11.3
20
17
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.9
11.3
161
917
H71
ICD-10 Finland
Cholesteatoma of middle ear
5.6
11.2
21
38
DFF00
NOMESCO Finland
Pure tone audiometry
2.0
10.9
124
653
H02AB07
ATC
prednisone; oral
1.8
10.8
166
968
L73.2
ICD-10 Finland
Hidradenitis suppurativa
4.8
10.7
24
51
R60.0
ICD-10 Finland
Localized oedema
1.9
10.6
142
791
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.0
10.4
117
614
L21.0
ICD-10 Finland
Seborrhoea capitis
5.2
10.3
21
41
I10
ICD-10 Finland
Essential (primary) hypertension
1.5
10.3
704
5810
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.2
10.2
88
418
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
2.1
10.1
92
446
J01DA09
ATC
[U] cefadroxil
1.6
10.1
320
2253
N02AX02
ATC
tramadol; systemic, rectal
1.5
10.1
517
4028
R5140
NOMESCO Finland
Monitoring the use of the aid
1.9
9.9
142
809
H60.4
ICD-10 Finland
Cholesteatoma of external ear
26.2
9.8
13
5
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
4.0
9.8
27
68
L04AA01
ATC
[U] ciclosporin
4.7
9.8
22
47
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.6
9.8
299
2086
S70
ICPC
Herpes zoster
3.1
9.8
41
137
R03AC02
ATC
salbutamol; inhalant
1.5
9.6
650
5324
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.7
9.6
193
1212
E000003, ,
ATC
2.5
9.6
58
235
E66.8
ICD-10 Finland
Other obesity
2.3
9.6
72
323
E66.01
ICD-10 Finland
Obesity due to excess calories
1.9
9.5
115
620
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.8
9.5
140
805
SPAT1254
SPAT
Administration of medicine
1.8
9.4
165
998
Z3226
NOMESCO Finland
Physiotherapist
1.7
9.4
214
1389
ZXD10
NOMESCO Finland
Scheduled procedure
1.5
9.3
437
3331
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
9.3
534
4233
T82
ICPC
Obesity
2.5
9.3
56
227
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
4.1
9.3
25
62
SPAT1260
SPAT
Consultation of another employee
1.7
9.2
202
1299
J02AC01
ATC
fluconazole; systemic
1.5
9.2
437
3341
L21
ICD-10 Finland
Seborrhoeic dermatitis
3.6
9.1
29
81
D05AX03
ATC
calcitriol; topical
4.5
9.1
22
50
E11
ICD-10 Finland
Type 2 diabetes mellitus
1.7
9.1
192
1222
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.5
9.1
468
3630
H65.2
ICD-10 Finland
Chronic serous otitis media
4.8
9.1
20
42
WZC00
NOMESCO Finland
Treatment plan or consultation
1.5
9.0
417
3166
S18
ICPC
Laceration/cut
1.4
8.9
527
4190
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
24.2
8.9
12
5
N05AA02
ATC
levomepromazine; systemic
2.5
8.9
57
238
ZXA10
NOMESCO Finland
Bilateral
1.6
8.9
212
1391
T36
ICD-10 Finland
Poisoning by systemic antibiotics
2.4
8.8
58
245
L08.8
ICD-10 Finland
Other specified local infections of skin and subcutaneous tissue
2.8
8.8
44
162
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.8
8.8
148
884
L21.9
ICD-10 Finland
Seborrhoeic dermatitis, unspecified
3.5
8.8
30
88
T90
ICPC
Diabetes non-insulin dependent
1.5
8.8
275
1924
J01MA12
ATC
levofloxacin; systemic
1.6
8.8
216
1429
C03CA01
ATC
furosemide; systemic
1.5
8.7
316
2281
M79.6
ICD-10 Finland
Pain in limb
1.4
8.7
486
3819
J01FA06
ATC
roxithromycin; oral
1.4
8.7
462
3597
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
8.7
333
2432
A02BC02
ATC
pantoprazole; systemic
1.4
8.7
806
6946
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.5
8.7
286
2024
WX110
NOMESCO Finland
Infiltration anesthesia
1.5
8.6
844
7338
L21.8
ICD-10 Finland
Other seborrhoeic dermatitis
4.1
8.5
23
57
J01DA06
ATC
[U] cefuroxime
1.7
8.5
168
1049
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.7
8.5
152
924
L30.3
ICD-10 Finland
Infective dermatitis
2.6
8.4
48
190
R02
ICPC
Shortness of breath/dyspnoea
1.7
8.4
146
881
L04AD01
ATC
ciclosporin; systemic
3.4
8.4
29
86
P01AB01
ATC
metronidazole; oral, rectal
1.4
8.3
464
3638
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
1.6
8.3
188
1218
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
1.9
8.2
110
613
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
3.7
8.2
25
68
DC1AD
NOMESCO Finland
Temporalbone CT
6.5
8.2
20
31
J05AB01
ATC
aciclovir; systemic
1.5
8.2
252
1754
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
4.1
8.1
22
55
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.9
8.1
101
551
L03.9
ICD-10 Finland
Cellulitis, unspecified
3.3
8.0
29
89
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.8
8.0
131
778
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.5
7.9
268
1902
X59
ICD-10 Finland
Exposure to unspecified factor
1.6
7.9
221
1504
L40.9
ICD-10 Finland
Psoriasis, unspecified
3.6
7.9
25
70
J01AA02
ATC
doxycycline; systemic
1.5
7.8
929
8286
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
2.6
7.8
45
179
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.7
7.8
144
883
Z2446
NOMESCO Finland
Social worker
2.0
7.8
83
428
D01AC02
ATC
miconazole; topical
1.9
7.8
94
507
R60.9
ICD-10 Finland
Oedema, unspecified
2.2
7.8
65
306
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
1.9
7.7
94
508
D02AE01
ATC
carbamide; topical
2.0
7.7
77
388
A03
ICPC
Fever
1.6
7.7
186
1223
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
2.3
7.7
55
242
R4110
NOMESCO Finland
Physiotherapy
1.5
7.6
313
2312
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.8
7.6
127
758
A10BA02
ATC
metformin; oral
1.5
7.6
326
2429
A02BC01
ATC
omeprazole; systemic
1.5
7.5
303
2226
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.2
7.5
64
303
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
2.3
7.5
55
245
RD210, ,
NOMESCO Finland
3.6
7.4
24
68
D09AB01
ATC
zinc bandage without supplements; topical
3.4
7.4
26
78
R74
ICPC
Upper respiratory infection acute
1.4
7.4
346
2617
H02AB04
ATC
methylprednisolone; systemic
1.6
7.4
162
1040
D05BB02
ATC
acitretin; oral
2.9
7.4
33
115
103
Kela drug reimbursment
Diabetes, insulin-treated
1.5
7.3
300
2212
H62.1
ICD-10 Finland
Otitis externa in viral diseases classified elsewhere
+∞
7.3
7
*
H620, A499,
ICD-10 Finland
+∞
7.3
7
*
SPAT1234
SPAT
Support of social functional capacity
2.2
7.3
58
268
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
2.1
7.2
65
315
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
2.0
7.2
73
370
L17
ICPC
Foot/toe symptom/complaint
1.5
7.2
316
2359
WX002
NOMESCO Finland
Sedation and analgesia
1.5
7.2
219
1518
XF400
NOMESCO Finland
ECG with 12 standard connections
1.6
7.2
173
1136
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
2.5
7.1
42
169
SPAT1310
SPAT
Counselling related to known health issue
1.4
7.1
351
2676
N05BA04
ATC
oxazepam; oral
1.5
7.1
291
2142
A04
ICPC
Weakness/tiredness general
1.6
7.1
156
1001
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
2.2
7.0
59
278
R95
ICPC
Chron obstructive pulmonary disease
2.7
7.0
36
135
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.1
7.0
65
319
L02.9
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle, unspecified
2.5
7.0
42
171
N06AX16
ATC
venlafaxine; oral
1.6
6.9
165
1080
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.0
6.9
69
348
TQW80
NOMESCO Finland
Local dermatologic skincare
2.8
6.9
34
125
JA1AE
NOMESCO Finland
Ultrasound examination of groin and abdominal wall
3.1
6.9
27
87
J45.9
ICD-10 Finland
Asthma, unspecified
1.5
6.9
209
1448
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.3
6.9
49
216
F29
ICPC
Eye symptom/complaint other
1.8
6.8
108
634
ZY010
NOMESCO Finland
Hospital outpatient
2.1
6.8
61
295
K10.3
ICD-10 Finland
Alveolitis of jaws
2.1
6.8
59
282
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.5
6.8
213
1485
ZXE00
NOMESCO Finland
One hour or less
1.4
6.8
437
3487
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
1.7
6.7
119
721
N18.8
ICD-10 Finland
Other chronic renal failure
3.0
6.7
29
99
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
2.2
6.7
55
257
A92
ICPC
Allergy/allergic reaction NOS
2.7
6.7
34
127
J01FA09
ATC
clarithromycin; systemic
1.4
6.7
351
2704
K11.2
ICD-10 Finland
Sialoadenitis
2.4
6.7
42
175
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
6.6
542
4487
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
1.9
6.6
81
439
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.8
6.6
101
587
WZC30
NOMESCO Finland
Teaching
1.6
6.6
176
1183
E66.00
ICD-10 Finland
Metabolic syndrome
2.0
6.6
71
368
EBA05
NOMESCO Finland
Complicated extraction of tooth
1.5
6.6
251
1820
K08.3
ICD-10 Finland
Retained dental root
1.8
6.6
91
513
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
3.0
6.6
28
95
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
3.8
6.5
19
50
E000007, ,
ATC
2.1
6.5
63
314
N05AH02
ATC
clozapine; systemic
3.0
6.5
27
90
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
6.5
434
3479
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
4.0
6.4
18
46
N06AX12
ATC
bupropion; oral
1.9
6.4
80
436
R06.0
ICD-10 Finland
Dyspnoea
1.4
6.4
295
2216
N06AB04
ATC
citalopram; systemic
1.5
6.4
223
1588
N03AX16
ATC
[U] pregabalin
1.5
6.4
265
1953
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.6
6.4
146
947
IGY99
NOMESCO Finland
Other psychiatric treatment contact
3.1
6.4
26
86
H71
ICPC
Acute otitis media/myringitis
4.1
6.4
17
42
EBA10
NOMESCO Finland
Operative extraction of tooth
1.6
6.3
135
860
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
3.6
6.3
20
56
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.5
6.3
177
1203
QX3HE
NOMESCO Finland
Ultrsound examination of lesion close to skin
3.4
6.3
22
66
ZYC01
NOMESCO Finland
Remote contact by phone
1.9
6.3
72
382
U07
ICPC
Urine symptom/complaint other
1.9
6.3
77
418
IAB12
NOMESCO Finland
Psychiatric psychosis consultation
+∞
6.3
6
*
ZXD35
NOMESCO Finland
Usual procedure
2.4
6.3
40
168
L02
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle
2.2
6.2
48
219
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
7.1
6.2
14
20
L20
ICD-10 Finland
Atopic dermatitis
2.7
6.2
32
121
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
2.4
6.2
40
169
319
Kela drug reimbursment
Adalimumab, brodalumab, certolizumab pegol, etanercept, guselkumab, infliximab, ixekizumab, risankizumab, sekukinumab and ustekinumab (skin psoriasis)
6.3
6.2
15
24
L02.8
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of other sites
3.3
6.2
22
67
C09CA01
ATC
losartan; oral
1.4
6.1
282
2116
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.6
6.1
158
1054
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.8
6.1
96
563
J01FA10
ATC
azithromycin; systemic
1.3
6.1
650
5580
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.0
6.1
68
358
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
2.3
6.0
44
196
G53.0*B02.20
ICD-10 Finland
Trigeminal neuralgia after shingles
10.1
6.0
11
11
SPAT1301
SPAT
No procedures
1.4
6.0
334
2589
U71
ICPC
Cystitis/urinary infection other
2.0
6.0
67
352
E000002, ,
ATC
1.7
6.0
113
697
K80.0
ICD-10 Finland
Calculus of gallbladder with acute cholecystitis
2.2
6.0
47
216

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
393
1159
4.47
121.92
2.2
1.7
—
—
—
0
0
574
2778
2.95
75.98
4.3
4.3
—
—
—
0
0
1199
10422
3.93
28.94
21.3
13.8
25.52
23.86
mg/l
1.20
1099
8230
691
4854
1.93
28.54
7.5
6.2
—
—
—
0
0
253
1240
2.30
28.03
2.0
1.4
—
—
—
0
0
737
5311
1.93
27.94
7.6
5.9
0.21
0.19
e9/l
1.75
647
4699
706
5132
1.85
24.82
7.2
5.6
0.60
0.58
e9/l
1.14
624
4469
706
5142
1.84
24.56
7.2
5.6
0.04
0.04
e9/l
0.86
621
4477
789
5964
1.86
24.18
12.5
8.9
4.17
4.11
e9/l
0.42
697
5247
717
5270
1.83
23.98
7.3
5.7
1.89
1.96
e9/l
0.55
641
4684
789
6044
1.81
22.26
5.2
4.9
6.78
6.70
mmol/l
0.48
749
5663
1196
10736
3.12
20.13
22.8
15.8
139.60
139.65
mmol/l
0.29
1171
10462
1196
10772
3.05
19.29
23.0
15.9
3.98
3.97
mmol/l
0.31
1169
10485
961
7979
1.85
19.04
9.3
7.5
81.09
77.23
u/l
0.76
907
7523
628
4658
1.69
18.37
7.4
5.9
0.71
0.67
%
0.82
588
4371
613
4522
1.69
18.27
6.5
6.2
1.21
1.21
mmol/l
0.05
567
4156
647
4845
1.69
18.19
7.8
6.1
8.62
8.59
%
0.08
607
4563
391
2555
1.77
18.08
9.2
6.6
—
—
—
0
0
263
1523
1.92
17.98
2.3
2.1
—
—
—
0
0
643
4823
1.68
17.84
7.3
5.8
3.09
2.86
%
1.55
602
4539
560
4058
1.68
17.67
2.1
2.0
93.59
94.91
pmol/l
0.25
315
2131
655
4961
1.66
17.31
7.6
5.9
27.06
27.92
%
1.24
614
4681
648
4898
1.66
17.23
7.2
5.7
57.66
57.11
%
0.57
607
4619
659
5004
1.66
17.20
8.2
6.9
1.21
1.21
mmol/l
0.27
566
4262
577
4328
1.61
15.13
6.2
4.9
35.39
35.63
g/l
0.46
543
4047
1082
9557
1.92
14.75
5.3
4.7
2.14
1.89
mu/l
0.61
989
8791
376
2564
1.66
14.27
4.4
3.8
89.44
90.89
%
0.51
365
2504
157
822
2.04
14.15
7.1
8.8
—
—
—
0
0
902
7632
1.64
13.58
4.8
4.0
13.73
11.80
mm/h
3.76
842
7075
344
2319
1.66
13.54
1.6
1.7
1.00
1.14
mg/l
0.62
265
1743
812
6703
1.59
13.51
5.0
4.3
1808.00
2429.86
e6/l
—
5
104
683
5437
1.56
13.18
7.0
6.3
12.20
11.43
umol/l
0.32
653
5166
607
4715
1.55
13.02
19.8
14.5
1.17
1.25
inr
1.25
165
1414
842
7048
1.58
12.86
4.9
4.2
—
—
—
0
0
357
2477
1.61
12.35
2.6
2.3
—
—
—
0
0
925
7949
1.61
12.32
4.4
3.9
14.45
14.78
pmol/l
4.04
855
7262
459
3398
1.55
11.93
3.6
3.5
2.36
2.35
mmol/l
0.50
406
3024
246
1567
1.71
11.80
1.9
2.1
29.42
29.73
s
0.35
238
1522
259
1692
1.67
11.26
2.7
2.7
1.05
1.05
e6/l
0.01
155
957
1074
9667
1.74
11.07
6.7
5.6
40.95
39.65
mmol/mol
3.57
967
9004
407
2978
1.54
10.95
3.9
3.3
628.35
306.31
mg/l
0.57
274
1936
436
3242
1.53
10.87
2.7
2.4
—
—
—
0
0
430
3194
1.52
10.75
3.7
3.2
7.62
7.72
mmol/l
0.18
369
2699
1234
11695
3.32
10.73
30.8
20.2
249.40
250.53
e9/l
0.24
1213
11402
331
2324
1.57
10.65
4.1
3.5
—
—
—
0
0
158
912
1.84
10.58
4.5
3.4
1.65
2.08
mmol/l
0.74
135
752
1234
11704
3.29
10.53
30.7
20.1
90.96
91.01
fl
0.13
1225
11535
1234
11704
3.29
10.53
30.8
20.2
7.00
6.70
e9/l
5.78
1210
11384
1234
11704
3.29
10.53
30.7
20.1
30.26
30.34
pg
0.82
1225
11534
1234
11705
3.29
10.51
30.8
20.1
4.48
4.52
e12/l
1.41
1210
11387
1233
11695
3.21
10.41
30.8
20.3
40.20
40.75
%
0.66
1179
10945
1234
11710
3.27
10.40
31.0
20.3
134.75
136.22
g/l
3.02
1225
11538
523
4079
1.48
10.18
4.1
3.3
5.69
5.83
ph
0.41
34
327
149
859
1.83
10.01
2.2
2.4
8.14
7.39
ug/l
0.15
134
776
215
1378
1.68
9.96
1.4
1.3
773.88
493.52
titre
0.85
49
287
507
3942
1.48
9.96
4.4
3.5
31.59
40.50
ng/l
0.97
359
2682
401
2974
1.51
9.94
4.4
4.1
7.40
7.40
ph
0.43
66
589
239
1575
1.64
9.94
2.9
2.4
12.68
13.49
umol/l
0.87
217
1470
349
2515
1.54
9.89
2.5
2.1
3.08
3.01
mg/l
0.21
302
2131
266
1802
1.60
9.88
1.7
1.7
1225.47
1202.55
nmol/l
0.14
194
1375
209
1347
1.66
9.45
3.1
2.5
21.92
23.71
%
1.05
179
1154
324
2317
1.54
9.45
1.6
1.5
18.73
20.69
nmol/l
1.42
268
1982
570
4568
1.45
9.41
11.7
9.3
0.00
0.00
e9/l
0.11
469
3767
827
7121
1.47
9.24
3.9
3.1
53.88
49.84
u/l
0.56
765
6683
221
1453
1.63
9.23
2.9
2.4
2.38
2.31
g/l
0.90
200
1348
450
3459
1.47
9.19
3.4
3.2
33.97
32.64
u/l
0.30
414
3284
1175
10983
1.99
9.15
18.8
13.0
—
—
—
0
0
415
3153
1.47
8.94
4.1
3.8
9.09
8.91
mg/mmol
0.03
281
2009
181
1143
1.68
8.82
6.1
8.6
0.81
1.22
mmol/l
0.73
140
913
181
1147
1.67
8.70
6.1
8.6
11.63
12.21
kpa
0.97
170
1109
181
1147
1.67
8.70
6.2
8.6
5.08
5.12
kpa
0.24
169
1106
1190
11200
2.07
8.65
13.7
10.2
28.25
26.71
u/l
1.84
1151
10828
134
786
1.79
8.49
2.6
2.7
9.92
10.72
g/l
1.68
125
724
402
3066
1.46
8.38
2.3
2.1
153.49
225.37
u/l
1.65
386
2900
454
3558
1.43
8.13
4.0
3.6
48.34
110.73
e6/l
1.63
321
2505
368
2775
1.46
8.09
3.3
3.0
0.51
0.48
e6/l
0.08
293
2094
140
845
1.74
8.03
3.7
3.3
—
—
—
0
0
198
1321
1.59
7.71
7.4
5.8
1.06
1.03
mmol/l
0.98
189
1236
230
1589
1.55
7.70
2.8
2.9
2.82
2.40
e6/l
0.19
126
859
257
1819
1.52
7.69
3.2
3.1
2.47
2.45
mmol/l
1.89
221
1614
269
1926
1.50
7.62
4.0
3.7
1136.25
412.03
ng/l
0.71
205
1471
161
1025
1.65
7.58
6.4
9.1
95.82
95.72
%
0.10
155
993
143
887
1.69
7.43
6.3
7.4
1.46
1.36
mmol/l
0.37
136
866
59
272
2.23
7.41
1.4
1.2
73.33
82.17
titre
—
6
23
132
804
1.72
7.33
3.1
2.9
229.02
196.92
ng/l
0.31
122
737
238
1675
1.52
7.29
4.0
3.4
0.81
0.82
mmol/l
1.28
224
1584
385
2981
1.42
7.19
3.5
3.0
—
—
—
0
0
143
897
1.67
7.12
8.8
7.5
10.73
9.55
mmol/l
1.10
137
856
358
2741
1.43
7.11
3.2
2.6
4296.57
6104.88
umol/l
0.32
311
2411
148
939
1.65
7.05
2.7
2.4
32.63
37.87
u/l
0.78
128
795
370
2856
1.42
7.00
3.2
3.0
1617.49
1262.15
ng/l
0.89
317
2438
78
410
1.96
6.96
4.7
4.6
—
—
—
0
0
352
2703
1.42
6.83
3.3
3.0
—
—
—
0
0
414
3281
1.39
6.66
2.8
2.6
63.13
60.71
u/l
0.12
394
3050
508
4169
1.37
6.56
2.6
2.2
73.73
76.46
nmol/l
1.48
467
3762
980
8936
1.43
6.45
26.5
17.5
332.03
332.78
g/l
1.63
973
8875
58
282
2.11
6.42
3.3
3.3
—
—
—
0
0
146
946
1.61
6.40
2.6
2.2
364.85
369.79
nmol/l
0.12
137
872
991
9061
1.43
6.37
23.1
16.4
15.06
14.81
%
0.68
985
8903
1133
10647
1.62
6.36
5.4
4.8
2.67
2.79
mmol/l
3.95
1042
9857
1092
10177
1.54
6.35
5.3
4.4
6.16
5.94
mmol/l
5.17
996
9314
581
4889
1.35
6.30
2.8
2.6
—
—
—
0
0
90
514
1.81
6.25
7.8
11.0
24.31
24.48
mmol/l
0.22
84
505
385
3041
1.38
6.24
3.5
3.2
184.14
80.26
e6/l
0.51
305
2328
128
812
1.64
6.11
2.5
3.0
66.11
66.66
g/l
0.35
115
750
169
1150
1.54
6.00
1.8
1.6
—
—
—
0
0
278
2093
1.42
5.93
2.7
2.6
7.11
5.65
e6/l
0.46
253
1896
596
5065
1.33
5.92
4.1
3.6
0.00
0.00
estimate
0.75
105
1027
16
31
5.21
5.71
1.1
1.6
—
—
—
0
0
102
621
1.70
5.70
1.6
1.8
1.00
1.39
g/l
3.04
92
579
592
5059
1.32
5.52
5.6
4.9
0.00
0.00
estimate
0.50
100
970
107
667
1.66
5.48
3.6
5.9
—
—
—
0
0
108
676
1.65
5.44
2.8
2.7
—
—
—
0
0
103
637
1.67
5.44
1.2
1.3
16.54
55.55
au/ml
—
5
39
1073
10036
1.46
5.39
4.3
3.9
1.41
1.31
mmol/l
3.93
972
9247
28
108
2.63
5.24
1.8
1.5
—
—
—
0
0
1110
10465
1.50
5.21
4.8
4.4
4.50
4.69
mmol/l
6.96
1024
9747
592
5105
1.30
4.99
4.2
3.6
0.00
0.01
estimate
0.80
97
934
350
2810
1.34
4.93
1.7
1.7
1.54
1.39
mmol/l
1.80
297
2352
19
61
3.15
4.92
1.1
1.0
—
—
—
0
0
45
221
2.07
4.92
1.9
2.4
—
—
—
0
0
1103
10409
1.47
4.91
4.8
4.3
1.36
1.45
mmol/l
13.16
1016
9638
112
728
1.59
4.87
1.5
1.4
—
—
—
0
0
16
38
4.25
4.83
1.3
1.4
—
—
—
0
0
103
658
1.62
4.81
1.3
1.3
761.98
214.43
u/ml
1.78
95
612
258
1983
1.38
4.80
1.5
1.5
2.50
2.45
g/l
0.15
156
1264
287
2245
1.36
4.78
4.8
3.9
1.02
1.02
kg/l
0.33
35
315
486
4103
1.30
4.74
2.2
2.1
—
—
—
0
0
164
1170
1.46
4.63
2.5
2.6
11.93
8.16
umol/l
0.47
143
1021
278
2179
1.35
4.55
1.6
1.7
51754817.20
28941993.39
pmol/l
0.26
228
1814
10
15
6.71
4.47
1.5
1.1
—
—
—
0
0
62
352
1.80
4.46
2.9
2.7
9.61
10.31
g/l
0.85
53
321
258
2010
1.36
4.38
3.2
2.8
543.38
544.58
mosm/kgh2o
0.03
224
1745
138
963
1.49
4.36
5.9
4.3
—
—
—
0
0
71
423
1.72
4.34
1.9
2.0
5.85
1.81
ug/l
0.53
57
389
68
403
1.73
4.24
5.6
3.9
24.91
24.90
mmol/l
0.01
61
381
26
108
2.44
4.24
1.2
1.6
—
—
—
0
0
518
4466
1.27
4.13
3.3
2.7
127.74
132.51
ug/l
0.17
472
4146
58
334
1.77
4.01
7.4
10.3
—
—
—
0
0
7
7
10.05
4.01
1.7
1.4
136.43
93.14
ng/l
—
7
7
110
748
1.52
3.95
1.6
1.4
—
—
—
0
0
75
467
1.64
3.92
5.5
3.6
—
—
—
0
0
282
2262
1.32
3.90
1.4
1.2
2.55
1.86
u/ml
0.29
74
630
52
293
1.81
3.87
1.5
1.5
245.32
284.43
ug/g
0.64
31
172
157
1151
1.42
3.84
1.9
1.6
—
—
—
0
0
803
7327
1.26
3.83
4.4
3.8
—
—
—
0
0
11
24
4.61
3.74
1.5
2.3
16.85
18.05
umol/l
0.18
11
24
226
1768
1.34
3.70
2.1
1.8
—
—
—
0
0
32
155
2.09
3.69
4.9
2.4
—
—
—
0
0
96
645
1.53
3.66
5.3
3.5
5.37
5.14
kpa
1.63
90
624
33
164
2.04
3.57
1.5
1.2
—
—
—
0
0
108
752
1.48
3.48
4.7
3.8
109.70
84.56
ng/l
1.32
98
672
24
106
2.29
3.47
1.3
1.3
13394.93
93797.58
e6/l
0.73
15
78
94
637
1.51
3.46
5.3
3.5
7.43
7.41
ph
0.67
12
86
16
58
2.78
3.43
1.1
1.0
—
—
—
0
0
48
275
1.77
3.42
1.3
1.2
—
—
—
0
0
130
943
1.42
3.39
2.6
2.2
0.21
0.22
g/l
0.05
118
883
146
1086
1.39
3.30
2.8
2.7
1.76
1.78
%
0.09
130
979
13
43
3.04
3.25
1.0
1.2
—
—
—
0
0
59
364
1.65
3.24
2.5
2.2
530.98
417.52
ug/l
0.17
53
344
54
328
1.68
3.15
3.5
2.0
—
—
—
0
0
53
321
1.68
3.13
1.4
1.2
—
—
—
0
0
118
856
1.42
3.09
3.8
4.1
0.75
1.04
%
1.13
48
306
13
41
3.19
3.06
2.3
1.6
—
—
—
0
0
184
1439
1.33
3.02
1.3
1.2
—
—
—
0
0
67
436
1.57
2.99
1.9
2.1
1.64
1.55
g/l
0.31
57
382
18
75
2.42
2.97
3.4
2.1
—
—
—
0
0
46
273
1.71
2.94
3.8
1.9
—
—
—
0
0
37
206
1.82
2.93
1.2
1.5
—
—
—
0
0
341
3971
0.81
2.89
2.9
2.8
—
—
—
0
0
111
808
1.41
2.86
3.7
4.1
0.10
0.13
%
0.20
41
257
23
109
2.13
2.85
2.7
4.2
—
—
—
0
0
107
775
1.42
2.84
3.5
4.0
0.82
0.64
%
0.38
40
259
25
123
2.05
2.82
1.0
1.2
—
—
—
0
0
40
231
1.76
2.82
4.8
3.3
41.00
34.60
umol/l
0.80
35
209
43
254
1.72
2.81
2.0
1.7
9881.32
13728.19
e6/l
0.48
31
191
105
763
1.41
2.74
3.7
4.2
0.03
0.55
%
0.67
36
212
56
357
1.59
2.74
3.6
1.8
—
—
—
0
0
61
398
1.56
2.71
1.2
1.2
0.32
1.25
u/ml
—
5
33
56
360
1.58
2.66
3.4
1.9
—
—
—
0
0
219
1790
1.27
2.58
1.2
1.3
18.70
35.58
iu/ml
2.65
54
564
56
363
1.57
2.57
3.5
1.9
—
—
—
0
0
344
2959
1.22
2.56
5.0
3.7
—
—
—
0
0
182
1456
1.29
2.54
1.8
1.6
—
—
—
0
0
405
3546
1.21
2.52
4.5
4.7
2.93
2.37
ug/l
0.38
352
3184
63
423
1.52
2.49
1.2
1.2
—
—
—
0
0
48
303
1.61
2.47
1.7
2.7
38.12
37.85
g/l
0.13
40
273
22
109
2.04
2.47
1.9
1.5
—
—
—
0
0
55
360
1.55
2.44
1.6
1.6
—
—
—
0
0
77
542
1.45
2.42
7.6
11.7
—
—
—
0
0
18
83
2.19
2.41
1.2
1.2
—
—
—
0
0
55
361
1.55
2.41
3.5
1.9
—
—
—
0
0
146
1144
1.31
2.39
1.4
1.3
—
—
—
0
0
39
236
1.67
2.37
3.5
2.6
—
—
—
0
0
8
22
3.65
2.36
1.3
1.1
—
—
—
0
0
30
169
1.79
2.34
1.3
1.1
—
—
—
0
0
207
1703
1.26
2.31
1.2
1.3
5.40
12.06
u/ml
1.44
72
670
318
2741
1.21
2.30
4.6
3.8
0.00
0.01
estimate
0.88
98
938
102
764
1.36
2.26
1.2
1.2
—
—
—
0
0
16
73
2.21
2.21
1.3
1.4
—
—
—
0
0
12
48
2.51
2.19
4.0
2.5
—
—
—
0
0
69
491
1.43
2.08
6.0
3.2
24.71
25.27
mmol/l
0.87
69
477
31
184
1.70
2.05
1.2
1.2
—
—
—
0
0
13
56
2.34
2.05
3.9
2.7
39492.31
38134.02
ug/l
0.17
13
56
106
816
1.33
1.99
3.0
2.7
69.22
70.08
e9/l
0.10
84
636
47
314
1.52
1.95
4.1
3.9
30.16
34.01
mg/l
0.26
42
254
49
331
1.50
1.94
1.2
1.3
—
—
—
0
0
35
219
1.62
1.92
1.2
1.3
—
—
—
0
0
160
1308
1.26
1.91
1.3
1.3
—
—
—
0
0
78
579
1.37
1.87
1.4
1.2
—
—
—
0
0
6
17
3.54
1.84
1.0
1.5
—
—
—
0
0
18
94
1.93
1.80
1.6
1.4
32.37
30.64
%
—
10
67
18
94
1.93
1.80
1.1
1.1
—
—
—
0
0
29
177
1.65
1.77
1.2
1.3
55.23
62.28
mmol/l
0.51
22
148
17
88
1.94
1.75
1.6
1.3
6.61
6.83
g/l
—
9
62
17
88
1.94
1.75
1.6
1.3
3.54
2.74
g/l
—
10
60
17
88
1.94
1.75
1.6
1.3
0.49
0.33
g/l
—
9
62
111
879
1.29
1.73
1.5
1.4
—
—
—
0
0
13
61
2.14
1.72
1.1
1.0
683.63
621.75
ng/l
—
8
36
67
495
1.37
1.68
2.6
2.4
—
—
—
0
0
33
212
1.57
1.66
1.2
1.2
183.34
267.39
u/ml
1.22
20
133
17
90
1.90
1.65
3.7
3.9
—
—
—
0
0
29
182
1.61
1.61
1.7
1.6
—
—
—
0
0
30
190
1.59
1.61
1.6
1.9
4.82
5.26
mmol/24h
0.33
30
168
17
91
1.88
1.61
1.6
1.3
—
—
—
0
0
34
222
1.55
1.61
2.2
2.2
134.04
129.15
g/l
0.59
24
167
8
32
2.51
1.60
1.1
1.1
—
—
—
0
0
8
32
2.51
1.60
2.6
2.6
—
—
—
0
0
50
355
1.43
1.58
3.3
3.8
0.60
0.28
g/l
0.73
22
153
35
231
1.53
1.58
1.2
1.4
5.10
45.32
e6/l
0.90
29
180
35
231
1.53
1.58
1.3
1.5
98.10
496.29
e6/l
0.66
30
187
7
26
2.70
1.58
1.0
1.0
—
—
—
0
0
148
1229
1.23
1.56
3.0
2.3
128.05
128.74
ug/g
0.01
124
980
10
44
2.28
1.55
1.1
9.3
—
—
—
0
0
24
145
1.67
1.55
1.5
1.5
0.33
0.33
nmol/l
0.01
17
114
12
232
0.51
1.53
2.3
3.5
19.78
26.14
mg/l
—
6
141
32
209
1.54
1.52
1.1
1.2
42.33
50.38
u/ml
—
8
18
7
27
2.60
1.51
1.9
2.0
—
—
—
0
0
19
108
1.77
1.51
2.7
2.4
—
—
—
0
0
22
132
1.68
1.46
1.1
1.3
—
—
—
0
0
58
430
1.37
1.45
1.6
1.4
—
9.21
—
0
12
32
212
1.52
1.44
1.6
1.4
—
—
—
0
0
26
164
1.60
1.44
1.2
1.1
—
—
—
0
0
12
59
2.04
1.43
1.3
1.5
—
—
—
0
0
23
141
1.64
1.42
1.1
1.3
—
0.45
—
0
13
10
46
2.18
1.40
1.1
1.2
—
73.67
%
—
0
6
20
119
1.69
1.38
1.6
1.6
51.62
59.41
%
—
10
81
31
207
1.51
1.36
2.9
2.7
17.67
16.14
%
1.26
15
108
32
216
1.49
1.34
2.1
1.7
—
—
—
0
0
10
47
2.14
1.34
42.5
31.1
86.60
120.73
ug/l
—
10
37
47
344
1.38
1.30
1.6
1.6
333.88
294.86
mu/l
0.25
42
314
12
62
1.94
1.28
4.4
4.7
—
—
—
0
0
13
70
1.87
1.24
5.2
2.9
40.15
40.65
%
—
6
38
34
237
1.45
1.23
5.1
4.0
—
—
—
0
0
23
147
1.58
1.23
1.6
2.4
—
—
—
0
0
79
632
1.27
1.20
2.5
3.4
4.44
4.54
pmol/l
0.42
74
558
14
79
1.78
1.17
1.2
1.1
—
—
—
0
0
24
159
1.52
1.12
2.0
1.5
—
—
—
0
0
23
151
1.53
1.12
1.8
1.5
0.75
0.75
g/l
0.00
15
116
19
119
1.61
1.12
1.1
1.1
—
—
—
0
0
7
33
2.13
1.05
1.0
1.0
—
—
—
0
0
12
67
1.80
1.05
2.8
1.6
—
—
—
0
0
42
315
1.34
1.04
2.2
1.7
40.76
39.27
nmol/l
0.09
37
304
317
2903
1.12
1.02
1.4
1.4
—
—
—
0
0
42
317
1.34
1.00
2.5
2.2
18015.91
2332.99
u/l
0.56
11
130
28
197
1.43
1.00
1.4
1.4
75.79
107.78
u/ml
—
8
37
9
48
1.88
1.00
1.4
2.8
783.44
1373.56
u/ml
—
9
48
84
695
1.22
0.98
3.9
3.1
11.64
5.95
e9/l
0.61
65
586
5
23
2.18
0.98
2.2
1.7
—
—
—
0
0
21
142
1.49
0.92
1.1
1.3
0.63
0.61
nmol/l
0.11
21
134
124
1072
1.17
0.92
1.7
1.4
—
—
—
0
0
16
103
1.56
0.87
1.3
2.0
7.63
4.79
umol/l
0.31
11
69
98
835
1.19
0.87
1.7
1.6
—
—
—
0
0
15
96
1.57
0.84
1.3
1.2
—
—
—
0
0
8
46
1.74
0.82
1.4
1.3
142.75
184.23
mmol/24h
—
8
46
56
685
0.81
0.81
1.4
1.4
—
—
—
0
0
24
172
1.40
0.81
1.0
1.2
—
—
—
0
0
8
47
1.71
0.80
1.0
1.0
—
11.97
—
0
9
5
97
0.51
0.78
1.0
1.1
—
—
—
0
0
6
34
1.77
0.76
6.5
4.7
—
—
—
0
0
10
59
1.70
0.76
1.2
1.3
5.14
5.84
ug/l
—
10
48
24
175
1.38
0.75
4.6
2.9
—
—
—
0
0
5
24
2.09
0.74
3.2
1.3
—
—
—
0
0
17
116
1.47
0.74
2.5
2.5
0.79
1.23
g/24h
—
7
57
18
125
1.45
0.73
1.1
1.3
—
—
nmol/l
—
0
0
13
84
1.55
0.72
1.8
2.3
1.00
2.05
u/field
—
5
40
17
117
1.46
0.72
2.8
2.5
—
—
—
0
0
7
40
1.75
0.71
1.0
1.1
—
—
—
0
0
41
327
1.26
0.71
3.6
8.0
1.36
1.28
mmol/l
0.25
36
291
5
27
1.86
0.68
1.0
1.1
—
—
—
0
0
226
2080
1.11
0.68
2.8
2.9
0.75
0.75
ug/l
0.00
151
1324
24
180
1.34
0.65
1.3
1.4
—
—
—
0
0
48
395
1.22
0.65
3.1
2.5
—
—
—
0
0
22
163
1.36
0.64
1.6
1.7
—
—
—
0
0
5
29
1.73
0.64
1.6
1.4
65.80
86.00
nmol/24h
—
5
29
8
50
1.60
0.61
1.3
1.2
—
—
—
0
0
56
658
0.84
0.58
2.5
2.8
—
—
—
0
0
24
184
1.31
0.58
4.5
2.6
—
—
—
0
0
13
89
1.47
0.58
1.2
1.3
481256.67
97247.25
e6/l
—
6
53
21
159
1.33
0.55
4.0
3.0
—
—
—
0
0
80
702
1.15
0.55
1.3
1.2
171.07
145.24
iu/ml
0.26
30
294
9
60
1.50
0.54
2.3
2.1
29.02
3.10
ug/l
—
9
53
66
574
1.16
0.52
1.5
1.7
—
—
—
0
0
19
248
0.76
0.52
2.0
2.3
—
—
—
0
0
7
107
0.65
0.48
1.4
1.2
—
—
—
0
0
23
181
1.28
0.48
1.1
1.1
—
—
—
0
0
33
272
1.22
0.47
4.7
4.3
7.44
7.42
ph
1.60
28
243
18
137
1.32
0.47
1.8
2.3
32.61
32.64
pg
0.01
18
137
28
227
1.24
0.47
1.5
2.2
0.87
0.84
nmol/l
0.08
23
192
28
229
1.23
0.44
5.1
4.7
2.40
2.53
mmol/l
0.08
21
153
13
95
1.37
0.43
1.7
1.5
—
—
—
0
0
38
322
1.19
0.43
1.1
1.3
346.21
226.47
miu/ml
0.78
13
149
12
87
1.38
0.42
1.9
1.8
13.93
11.13
%
2.28
12
87
91
824
1.11
0.42
2.6
2.2
11.38
13.02
nmol/l
1.09
79
747
5
33
1.52
0.41
2.2
1.9
—
—
—
0
0
53
464
1.15
0.41
1.6
1.4
27.73
30.33
iu/l
0.21
44
395
5
35
1.43
0.39
2.0
1.6
—
—
—
0
0
5
35
1.43
0.39
1.0
1.1
—
—
—
0
0
74
667
1.12
0.38
1.3
1.2
—
—
—
0
0
5
37
1.35
0.37
4.0
2.8
—
—
—
0
0
22
180
1.23
0.36
1.1
1.1
—
—
—
0
0
6
44
1.37
0.34
1.2
1.1
3035.83
1609.41
miu/ml
—
6
44
53
473
1.13
0.33
1.1
1.1
—
—
—
0
0
12
92
1.31
0.32
1.2
1.3
—
—
—
0
0
25
211
1.19
0.31
3.6
3.9
57.76
57.27
%
0.08
25
211
20
240
0.83
0.31
1.3
1.3
—
—
—
0
0
19
229
0.83
0.30
1.6
1.6
—
—
—
0
0
14
111
1.26
0.30
1.2
1.2
—
—
—
0
0
7
55
1.27
0.30
1.7
1.3
133.97
153.07
nmol/l
—
7
55
7
55
1.27
0.30
1.4
1.3
167.29
512.98
u/l
—
7
50
24
204
1.18
0.28
3.5
3.5
4.07
4.36
e9/l
0.32
24
204
26
223
1.17
0.28
3.5
3.8
—
—
—
0
0
8
63
1.27
0.27
1.4
1.4
—
—
—
0
0
5
71
0.70
0.26
1.2
1.0
—
—
—
0
0
5
73
0.68
0.26
1.4
1.4
69.86
163.63
pmol/l
—
5
73
90
843
1.07
0.24
6.3
3.7
1.23
1.23
mmol/l
0.11
80
733
13
157
0.83
0.22
1.1
1.0
1.16
0.83
u/ml
—
7
62
14
116
1.21
0.22
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
3.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
14
117
1.20
0.20
1.1
1.2
—
—
—
0
0
10
80
1.25
0.20
1.2
1.3
—
—
—
0
0
6
49
1.23
0.20
1.0
1.3
—
—
—
0
0
14
118
1.19
0.19
3.0
2.4
—
—
—
0
0
46
498
0.92
0.19
5.3
3.6
—
—
—
0
0
7
59
1.19
0.18
6.4
2.1
10.29
10.13
mmol/l
—
7
59
5
69
0.72
0.17
2.0
2.2
434.20
491.11
min
—
5
47
5
70
0.71
0.16
1.4
1.3
1.47
1.55
g/l
—
5
70
8
70
1.14
0.16
1.3
1.1
—
—
—
0
0
18
158
1.14
0.16
1.2
1.2
—
—
—
0
0
19
168
1.13
0.15
1.1
1.1
—
13.07
—
0
12
95
992
0.95
0.15
1.5
1.4
—
—
—
0
0
31
285
1.09
0.14
1.1
1.1
—
—
—
0
0
19
210
0.90
0.12
1.1
1.2
—
—
—
0
0
41
385
1.07
0.12
1.0
1.1
—
—
—
0
0
107
1035
1.04
0.11
3.3
4.3
5.72
26.21
ug/l
1.64
81
861
15
167
0.90
0.10
1.1
1.0
6.09
5.36
u/ml
—
9
82
17
154
1.11
0.10
1.1
1.0
2.28
2.02
u/ml
—
10
78
5
44
1.14
0.10
2.4
1.6
—
—
—
0
0
5
47
1.06
0.09
1.2
1.1
—
19.83
—
0
6
5
62
0.81
0.08
3.6
7.0
—
—
—
0
0
16
146
1.10
0.08
1.2
1.2
—
—
—
0
0
5
63
0.79
0.08
2.6
3.0
—
—
—
0
0
14
127
1.10
0.08
1.1
1.0
23.41
4.31
u/ml
—
7
51
8
74
1.08
0.07
1.8
1.5
81.63
78.69
umol/l
—
8
74
12
108
1.11
0.07
2.3
2.4
—
—
—
0
0
13
142
0.91
0.06
1.1
1.0
24.28
2.85
u/ml
—
7
70
28
266
1.05
0.06
1.6
1.8
4.99
4.90
iu/l
—
8
91
12
111
1.08
0.04
1.3
1.6
—
—
—
0
0
278
2801
0.99
0.04
3.7
3.3
—
—
—
0
0
90
889
1.01
0.02
4.2
3.7
—
—
—
0
0
12
113
1.06
0.02
1.9
1.8
—
—
—
0
0
19
184
1.03
0.00
1.2
1.1
7.18
2.83
u/ml
0.43
12
96
26
266
0.98
0.00
2.7
2.3
148.73
129.09
ug/min
0.12
18
162
46
454
1.01
0.00
1.7
1.8
—
—
—
0
0
12
116
1.03
0.00
1.8
1.3
—
—
—
0
0
13
128
1.02
0.00
2.9
2.5
—
—
—
0
0
14
138
1.01
0.00
2.6
2.8
—
—
—
0
0
26
262
0.99
0.00
7.3
4.6
—
—
—
0
0
13
131
0.99
0.00
2.9
2.5
106.23
105.66
mmol/l
0.17
13
131
13
131
0.99
0.00
2.9
2.5
4.08
4.06
mmol/l
0.10
13
131
17
171
0.99
0.00
1.4
1.5
—
—
—
0
0
16
163
0.98
0.00
1.4
1.4
—
—
—
0
0
16
163
0.98
0.00
1.4
1.4
—
—
—
0
0
17
167
1.02
0.00
1.1
1.2
1.82
6.65
u/ml
1.57
11
66
109
1095
1.00
0.00
1.3
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
6
60
1.00
0.00
1.3
2.5
2136.67
2064.79
ml
—
6
52
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.4
—
—
—
0
0
5
55
0.91
-0.00
2.8
3.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
181.29
—
0
7
8
85
0.94
-0.00
2.1
1.5
0.94
0.99
g/l
—
8
85
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
2.08
—
0
6
5
54
0.93
-0.00
1.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
33.26
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
7.80
—
0
5
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H8_EXTDISINOTH and mortality.

Females

Parameter HR [95% CI] p-value
H8_EXTDISINOTH 1.404 [1.19, 1.66] < 0.001
Birth year 0.998 [0.99, 1.01] 0.619

During the follow-up period (1.1.1998 — 31.12.2019), 419 out of 2954 females with H8_EXTDISINOTH died.

Males

Parameter HR [95% CI] p-value
H8_EXTDISINOTH 1.515 [1.27, 1.8] < 0.001
Birth year 0.987 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 517 out of 3092 males with H8_EXTDISINOTH died.

Mortality risk

Mortality risk for people of age

years, who have H8_EXTDISINOTH.

N-year risk Females Males
1 0.167% 0.355%
5 0.973% 1.728%
10 2.414% 4.346%
15 4.32% 8.045%
20 7.788% 13.438%

Relationships between endpoints

Index endpoint: H8_EXTDISINOTH – Disorder of external ear, unspecified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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