appendicitis: Acute inflammation of the vermiform appendix.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3563 |
4. Check minimum number of eventsNone |
3563 |
5. Include endpointsNone |
3563 |
6. Filter based on genotype QC (FinnGen only) |
3563 |
Control definitions (FinnGen only)
- Control exclude
- K11_APPENDIX
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other appendicitis
based on the number of shared cases.
Similar with more cases:
- Appendicitis, broad definition
- Diseases of appendix
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 30807 | 15923 | 14710 |
| Only index persons | 27597 | 14579 | 13018 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.43 | 0.46 | 0.41 |
| Only index persons | 0.52 | 0.54 | 0.50 |
| Median age at first event (years) | |||
| Whole population | 26.65 | 26.67 | 26.39 |
| Only index persons | 25.39 | 25.68 | 25.07 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3563 | 2101 | 1462 |
| Unadjusted period prevalence (%) | 0.69 | 0.72 | 0.64 |
| Median age at first event (years) | 28.11 | 26.74 | 30.08 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 3225
- Matched controls
- 32249
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
54199
ICD-8 Finland
Appendicitis, unqualified
+∞
323.0
1187
*
JEA01
NOMESCO Finland
Laparoscopic appendectomy
75.9
323.0
512
80
5410X
ICD-9 Finland
Appendicitis, unqualified[APPENDICITIS NUD]
+∞
323.0
600
*
K35.9
ICD-10 Finland
Acute appendicitis, unspecified
536.4
323.0
463
10
K37
ICD-10 Finland
Unspecified appendicitis
642.8
323.0
668
13
6421
FHL
Appendicectomy
30.1
323.0
715
302
K36
ICD-10 Finland
Other appendicitis
+∞
279.3
264
*
54200
ICD-8 Finland
Other appendicitis, Appendicitis chronica
+∞
220.4
209
*
5428X
ICD-9 Finland
Other appendicitis[APPENDICITIS ALIA DEFINITA]
+∞
103.7
99
*
54208
ICD-8 Finland
Other appendicitis
+∞
100.5
96
*
JEA00
NOMESCO Finland
Appendectomy
7.1
82.8
212
316
K35.1
ICD-10 Finland
Acute appendicitis with peritoneal abscess
+∞
81.6
78
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
65.2
1190
7338
K35.0
ICD-10 Finland
Acute appendicitis with generalized peritonitis
+∞
63.7
61
*
54003
ICD-8 Finland
Acute appendicitis, Cum abscessu
+∞
44.9
43
*
5420A
ICD-9 Finland
Other appendicitis[APPENDICITIS CHRONICA]
+∞
43.8
42
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.5
43.3
379
1643
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.9
41.0
704
4100
P01AB01
ATC
metronidazole; oral, rectal
1.7
38.8
1232
8699
54099
ICD-8 Finland
Acute appendicitis, Without mention of peritonitis
+∞
38.6
37
*
5409X
ICD-9 Finland
Acute appendicitis, Without mention of peritonitis
+∞
34.4
33
*
JN3AD
NOMESCO Finland
Abdominal CT examination
2.4
28.2
253
1102
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
27.8
775
5173
N02BE01
ATC
paracetamol; systemic, rectal
1.6
25.1
2604
23339
5401A
ICD-9 Finland
Acute appendicitis, With peritoneal abscess
+∞
25.0
24
*
A02BC05
ATC
esomeprazole; systemic
1.5
24.3
1175
8911
N02AX02
ATC
tramadol; systemic, rectal
1.5
24.1
1206
9208
J01DB01
ATC
cefalexin; oral
1.5
21.0
2471
22127
A02BC02
ATC
pantoprazole; systemic
1.4
19.9
1855
15773
54201
ICD-8 Finland
Other appendicitis, Appendicitis recidivans
+∞
19.8
19
*
M01AB05
ATC
diclofenac; systemic, rectal
1.4
18.3
2001
17371
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
17.6
1333
10824
D88
ICPC
Appendicitis
170.8
16.5
17
*
J01AA02
ATC
doxycycline; systemic
1.4
16.4
2323
20874
WX402
NOMESCO Finland
General anaesthesia
1.6
16.0
478
3196
M03BX02
ATC
tizanidine; oral
1.4
15.6
1851
16069
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.6
15.2
440
2916
78551
ICD-8 Finland
Symptoms referable to abdomen and lower gastro-intestinal tract, Symptomata abdominalis acuta NUD
2.7
14.8
101
382
R07.4
ICD-10 Finland
Chest pain, unspecified
1.5
14.6
672
4937
N03AX16
ATC
pregabalin; oral
1.5
14.4
632
4600
M01AE03
ATC
ketoprofen; systemic, rectal
1.4
14.2
1040
8305
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.6
13.8
403
2678
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
2.1
13.3
160
800
UJF32
NOMESCO Finland
Coloscopy
1.4
13.0
643
4782
M01AE01
ATC
ibuprofen; systemic, rectal
1.5
12.9
2761
25916
M01AE02
ATC
naproxen; oral, rectal
1.3
12.9
1608
13881
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.6
12.4
335
2179
H02AB06
ATC
prednisolone; systemic
1.3
11.7
1243
10429
K35
ICD-10 Finland
Acute appendicitis
16.4
11.7
18
11
M79.6
ICD-10 Finland
Pain in limb
1.3
11.6
936
7543
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.3
11.6
1189
9928
5421A
ICD-9 Finland
Other appendicitis[APPENDICITIS RECIDIVANS]
+∞
11.5
11
*
A02BC03
ATC
lansoprazole; oral
1.4
10.9
757
5947
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.3
10.6
1063
8819
54191
ICD-8 Finland
NA
+∞
10.4
10
*
R51.80
ICD-10 Finland
Headache
1.5
10.4
373
2593
JAH01
NOMESCO Finland
Laparoscopy
2.0
9.9
119
597
A02BC01
ATC
omeprazole; systemic
1.3
9.5
678
5337
J01MA02
ATC
ciprofloxacin; systemic
1.3
9.4
988
8213
WX704
NOMESCO Finland
Intubation
1.7
9.4
193
1168
D01
ICPC
Abdominal pain/cramps general
1.6
9.1
258
1697
J01MA12
ATC
levofloxacin; systemic
1.4
8.9
437
3224
99850
ICD-8 Finland
Other complications of surgical procedures, Postoperative wound infection
5.2
8.9
26
50
R51
ICD-10 Finland
Headache
1.9
8.8
134
736
R10.0
ICD-10 Finland
Acute abdomen
2.2
8.5
80
364
A03FA02
ATC
cisapride; oral, rectal
1.7
8.4
184
1133
54100
ICD-8 Finland
NA
+∞
8.3
8
*
AA1AD
NOMESCO Finland
CT of head and brain
1.3
8.0
527
4084
R03AC02
ATC
salbutamol; inhalant
1.2
8.0
1425
12569
N03AX12
ATC
gabapentin; oral
1.4
8.0
375
2745
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.4
8.0
473
3607
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.4
7.9
406
3019
Z48.0
ICD-10 Finland
Attention to surgical dressings and sutures
2.1
7.9
90
443
N02AJ06
ATC
codeine and paracetamol; systemic
1.3
7.9
985
8332
M01AH05
ATC
etoricoxib; oral
1.2
7.8
1667
14979
WX110
NOMESCO Finland
Local anesthesy
1.2
7.8
1951
17839
J01DA06
ATC
[U] cefuroxime; systemic
1.4
7.7
372
2740
J01FA10
ATC
azithromycin; systemic
1.2
7.6
1637
14708
R05FA02
ATC
opium derivatives and expectorants; systemic
1.2
7.4
1041
8915
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.3
7.4
681
5537
Y0599
ICD-8 Finland
Investigation of digestive system
2.7
7.3
47
174
J01EA01
ATC
trimethoprim; systemic
1.3
7.3
606
4859
54091
ICD-8 Finland
Acute appendicitis, Gangraenosa, peritonitide non indicata
+∞
7.3
7
*
A06AC01
ATC
ispaghula (psylla seeds); oral
1.3
7.2
563
4475
TPH04
NOMESCO Finland
Cathetrisation of vein
1.3
7.1
499
3900
G44.2
ICD-10 Finland
Tension-type headache
1.4
7.1
326
2375
J01FA09
ATC
clarithromycin; systemic
1.3
7.0
847
7116
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.3
7.0
439
3378
A02BA04
ATC
nizatidine; systemic
1.6
7.0
174
1113
M01AH01
ATC
celecoxib; oral (coxibs)
1.3
7.0
435
3343
J01CE02
ATC
phenoxymethylpenicillin; oral
1.2
6.9
1960
18034
SPAT1263
SPAT
Sampling
1.2
6.9
1086
9405
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
1.7
6.8
137
825
N05BA04
ATC
oxazepam; oral
1.3
6.8
613
4960
M53.1
ICD-10 Finland
Cervicobrachial syndrome
1.4
6.8
269
1905
R50.9
ICD-10 Finland
Fever, unspecified
1.4
6.8
315
2302
J01FA06
ATC
roxithromycin; oral
1.2
6.7
1070
9270
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.4
6.7
349
2603
R06.0
ICD-10 Finland
Dyspnoea
1.3
6.7
559
4484
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.2
6.7
1375
12232
N05BA01
ATC
diazepam; systemic, rectal
1.4
6.6
317
2329
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.2
6.6
1530
13770
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.4
6.5
288
2086
1220
FHL
Arthroscopy
1.8
6.5
100
557
R03BA05
ATC
fluticasone; inhalant
1.3
6.5
441
3434
ZXA10
NOMESCO Finland
Bilateral
1.3
6.5
401
3079
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.3
6.4
410
3159
D37.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Appendix
7.4
6.4
14
19
Z01.8
ICD-10 Finland
Other specified special examinations
1.3
6.3
510
4066
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.5
6.3
209
1427
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
2.0
6.3
76
388
C07AB07
ATC
bisoprolol; oral
1.2
6.3
1087
9487
K38.9
ICD-10 Finland
Disease of appendix, unspecified
+∞
6.2
6
*
54190
ICD-8 Finland
NA
+∞
6.2
6
*
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.3
6.2
672
5566
78559
ICD-8 Finland
Symptoms referable to abdomen and lower gastro-intestinal tract, Colica abdominalis NUD
1.9
6.1
81
426
G43.9
ICD-10 Finland
Migraine, unspecified
1.6
6.1
132
814
UKC02
NOMESCO Finland
Cystoscopy
1.4
6.1
333
2499
A02BA02
ATC
ranitidine; systemic
1.3
6.1
456
3595
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
1.6
6.1
135
839
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.4
6.1
250
1784
M01AX17
ATC
nimesulide; oral
1.3
6.0
582
4750
N05CF01
ATC
zopiclone; oral
1.2
6.0
768
6477
NA1CM
NOMESCO Finland
Cervical spine extensive MRI examination with 3 Tesla magnet
10.0
6.0
11
11
Mortality – FinRegistry
↥Association
Association between endpoint K11_APPENDOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_APPENDOTH | 1.152 [0.93, 1.43] | 0.2 |
| Birth year | 0.992 [0.98, 1.0] | 0.062 |
During the follow-up period (1.1.1998 — 31.12.2019), 155 out of 3277 females with K11_APPENDOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_APPENDOTH | 1.066 [0.88, 1.3] | 0.52 |
| Birth year | 0.991 [0.98, 1.0] | 0.089 |
During the follow-up period (1.1.1998 — 31.12.2019), 202 out of 3197 males with K11_APPENDOTH died.
Mortality risk
Mortality risk for people of age
years, who have K11_APPENDOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.088% | 0.285% |
| 5 | 0.562% | 1.552% |
| 10 | 1.442% | 3.661% |
| 15 | 2.692% | 6.828% |
| 20 | 4.667% | 11.537% |
Relationships between endpoints
↥Index endpoint: K11_APPENDOTH – Other appendicitis
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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