musculoskeletal system disease: A disease involving the musculoskeletal system. [database_cross_reference: MONDO:DesignPattern]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1771 |
4. Check minimum number of eventsNone |
1771 |
5. Include endpointsNone |
1771 |
6. Filter based on genotype QC (FinnGen only) |
1771 |
Control definitions (FinnGen only)
- Control exclude
- M13_MUSCULOSKELEOTH
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M95-M99
- Name in latin
- Laesio biomechanica non alibi classificata
Similar endpoints
↥List of similar endpoints to
Biomechanical lesions, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Other disorders of the musculoskeletal system and connective tissue
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 11514 | 6360 | 5079 |
| Only index persons | 9818 | 5551 | 4267 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.18 | 0.14 |
| Only index persons | 0.19 | 0.20 | 0.16 |
| Median age at first event (years) | |||
| Whole population | 53.30 | 53.79 | 52.53 |
| Only index persons | 50.54 | 51.17 | 49.72 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1771 | 1046 | 725 |
| Unadjusted period prevalence (%) | 0.34 | 0.36 | 0.32 |
| Median age at first event (years) | 53.53 | 50.48 | 57.93 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1548
- Matched controls
- 15481
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M99.3
ICD-10 Finland
Osseous stenosis of neural canal
3054.1
285.3
267
*
M99.6
ICD-10 Finland
Osseous and subluxation stenosis of intervertebral foramina
611.8
266.7
257
5
7396A
ICD-9 Finland
Nonallopathic lesions, not elsewhere classified, Lower extremities
+∞
238.9
223
*
M48.0
ICD-10 Finland
Spinal stenosis
7.1
179.5
508
996
M99.8
ICD-10 Finland
Other biomechanical lesions
1736.8
160.2
153
*
M99.5
ICD-10 Finland
Intervertebral disc stenosis of neural canal
473.5
133.2
131
*
M99.0
ICD-10 Finland
Segmental and somatic dysfunction
1357.3
130.1
125
*
M99.9
ICD-10 Finland
Biomechanical lesion, unspecified
445.7
125.7
124
*
N03AX16
ATC
pregabalin; oral
3.9
113.5
619
2277
N02AX02
ATC
tramadol; systemic, rectal
3.2
103.8
908
4717
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
6.9
98.1
264
445
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
5.2
91.7
320
742
N03AX12
ATC
gabapentin; oral
3.9
88.5
435
1408
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
7.6
88.0
219
327
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
4.1
87.6
405
1240
M54.4
ICD-10 Finland
Lumbago with sciatica
3.8
83.0
426
1420
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
4.6
73.6
285
725
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.9
70.7
338
1044
7397A
ICD-9 Finland
Nonallopathic lesions, not elsewhere classified, Upper extremities
+∞
67.2
64
*
M54.5
ICD-10 Finland
Low back pain
2.7
65.9
651
3311
M79.6
ICD-10 Finland
Pain in limb
2.5
59.0
675
3663
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
4.3
54.6
221
577
L03
ICPC
Low back symptom/complaint
2.6
52.4
482
2285
7385A
ICD-9 Finland
Other acquired deformity of back or spine
+∞
51.3
49
*
ABC56
NOMESCO Finland
Decompression of lumbar spinal canal and nerve roots
9.1
51.2
111
130
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.2
49.8
819
5173
R4110
NOMESCO Finland
Physiotherapy
2.4
46.8
515
2657
M43.1
ICD-10 Finland
Spondylolisthesis
6.0
46.2
133
237
N02AJ06
ATC
codeine and paracetamol; systemic
2.2
45.2
670
3974
1220
FHL
Arthroscopy
5.4
43.4
138
277
M01AH05
ATC
etoricoxib; oral
2.0
39.3
957
6843
L28
ICPC
Limited function/disability (L)
2.6
37.5
314
1371
M03BX02
ATC
tizanidine; oral
2.0
37.4
1005
7398
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
6.0
37.1
106
187
M01AB05
ATC
diclofenac; systemic, rectal
2.0
36.9
1067
8063
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
4.9
35.6
122
266
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
34.5
628
3928
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.9
34.3
232
886
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
3.8
33.8
154
441
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
4.1
33.7
137
354
Z3226
NOMESCO Finland
Physiotherapist
2.3
33.6
354
1740
A02BC02
ATC
pantoprazole; systemic
2.0
33.5
1046
7971
M54.1
ICD-10 Finland
Radiculopathy
4.7
33.3
117
262
N06AX21
ATC
duloxetine; oral
2.9
33.1
229
887
M03BC01
ATC
orphenadrine (citrate); systemic
2.2
32.5
422
2280
L86
ICPC
Back syndrome with radiating pain
3.7
31.9
147
424
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.4
31.1
296
1375
M54.3
ICD-10 Finland
Sciatica
3.6
30.0
145
435
M01AE03
ATC
ketoprofen; systemic, rectal
1.9
29.6
639
4191
N02BE01
ATC
paracetamol; systemic, rectal
2.2
29.4
1342
11504
7392A
ICD-9 Finland
Nonallopathic lesions, not elsewhere classified, Thoracic region
+∞
29.3
28
*
N06AA09
ATC
amitriptyline; systemic
2.8
29.2
211
837
M01AH01
ATC
celecoxib; oral (coxibs)
2.2
29.0
341
1748
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
28.9
639
4215
X59
ICD-10 Finland
Exposure to unspecified factor
2.2
28.0
328
1677
WX402
NOMESCO Finland
General anaesthesia
2.3
28.0
303
1492
M25.5
ICD-10 Finland
Pain in joint
2.0
27.9
470
2793
NAG62
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, 2-3 vertebraea
7.5
27.9
67
93
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.9
27.3
577
3723
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.7
27.2
210
865
M99.4
ICD-10 Finland
Connective tissue stenosis of neural canal
+∞
27.2
26
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
27.0
455
2701
M47.9
ICD-10 Finland
Spondylosis, unspecified
4.6
26.9
97
223
WX110
NOMESCO Finland
Local anesthesy
1.8
26.8
1043
8220
R06.0
ICD-10 Finland
Dyspnoea
2.0
26.5
416
2399
M96.1
ICD-10 Finland
Postlaminectomy syndrome, not elsewhere classified
264.8
25.8
26
*
M01AE02
ATC
naproxen; oral, rectal
1.8
25.6
869
6500
ZXE00
NOMESCO Finland
One hour or less
1.8
25.2
640
4359
L17
ICPC
Foot/toe symptom/complaint
2.0
24.9
410
2399
M70.6
ICD-10 Finland
Trochanteric bursitis
2.4
24.9
223
995
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
3.7
24.1
111
320
M53.1
ICD-10 Finland
Cervicobrachial syndrome
2.5
24.0
197
839
Z2221
NOMESCO Finland
Medical doctor
1.8
22.6
467
2944
M03BC51
ATC
orphenadrine, combinations; systemic
1.8
22.6
455
2847
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.9
22.4
389
2306
R07.4
ICD-10 Finland
Chest pain, unspecified
1.9
22.3
430
2648
G56.0
ICD-10 Finland
Carpal tunnel syndrome
2.3
22.0
234
1133
7395A
ICD-9 Finland
Nonallopathic lesions, not elsewhere classified, Pelvic region
+∞
21.9
21
*
M99.7
ICD-10 Finland
Connective tissue and disc stenosis of intervertebral foramina
116.7
21.6
23
*
R03AC02
ATC
salbutamol; inhalant
1.7
21.2
798
6011
M79.0
ICD-10 Finland
Rheumatism, unspecified
3.9
21.1
88
233
M54.2
ICD-10 Finland
Cervicalgia
2.8
21.0
142
536
M47.82
ICD-10 Finland
Other spondylosis, cervical region
3.8
21.0
92
255
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
5.1
20.8
67
137
A06AC01
ATC
ispaghula (psylla seeds); oral
1.9
20.8
397
2423
M01AC06
ATC
meloxicam; systemic, rectal
1.7
20.8
571
3919
A02BC05
ATC
esomeprazole; systemic
1.7
20.2
630
4480
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
4.0
20.0
82
214
M79.1
ICD-10 Finland
Myalgia
2.2
19.8
215
1048
7393A
ICD-9 Finland
Nonallopathic lesions, not elsewhere classified, Lumbar region
+∞
19.8
19
*
R52.2
ICD-10 Finland
Other chronic pain
4.0
19.7
81
212
ZXA05
NOMESCO Finland
Left side
1.8
19.6
410
2577
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
19.6
466
3051
B01AB05
ATC
enoxaparin; parenteral
1.7
19.5
486
3221
S18
ICPC
Laceration/cut
1.7
19.3
627
4489
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.9
19.3
337
1987
G55.2*M47.9
ICD-10 Finland
Nerve root and plexus compressions in spondylosis
6.3
19.2
51
83
L02
ICPC
Back symptom/complaint
2.5
18.9
153
641
M01AX17
ATC
nimesulide; oral
1.8
18.9
398
2501
N06AX16
ATC
venlafaxine; oral
2.1
18.9
228
1166
A01
ICPC
Pain general/multiple sites
2.6
18.7
140
564
JAG96
NOMESCO Finland
Other reconstruction of abdominal wall
24.0
18.7
26
11
SAA01
NOMESCO Finland
Simple examination of mouth
1.6
18.6
1022
8392
ZXE20
NOMESCO Finland
More than three and less than five hours
2.1
18.5
233
1210
M19.0
ICD-10 Finland
Primary arthrosis of other joints
2.4
18.3
164
728
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
2.8
18.3
123
464
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.8
18.2
119
441
M54
ICD-10 Finland
Dorsalgia
2.2
18.2
197
956
A02BC01
ATC
omeprazole; systemic
1.7
18.1
443
2912
ABC30
NOMESCO Finland
Decompression of cervical nerve roots
8.5
18.0
39
47
M02AA07
ATC
piroxicam; topical
1.7
18.0
571
4043
M50.3
ICD-10 Finland
Other cervical disc degeneration
4.8
17.9
60
129
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
6.3
17.8
47
76
9183
FHL
Posterolateral spondylodesis
67.4
17.7
20
*
L08
ICPC
Shoulder symptom/complaint
1.9
17.7
298
1733
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
17.6
325
1947
M47.1
ICD-10 Finland
Other spondylosis with myelopathy
7.3
17.6
42
59
L12
ICPC
Hand/finger symptom/complaint
2.1
17.4
219
1134
J01AA02
ATC
doxycycline; systemic
1.7
17.4
1179
10137
J01DB01
ATC
cefalexin; oral
1.7
17.3
1225
10656
N05CF01
ATC
zopiclone; oral
1.7
17.2
500
3442
ZXA00
NOMESCO Finland
Right side
1.7
17.2
428
2819
WX320
NOMESCO Finland
Spinalanesthesy
1.8
16.9
355
2220
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.7
16.8
448
3007
UJF32
NOMESCO Finland
Coloscopy
1.7
16.8
403
2623
QBJ30
NOMESCO Finland
Correction of abdominal apron
8.9
16.7
35
40
7399X
ICD-9 Finland
Nonallopathic lesions, not elsewhere classified, Abdomen and other
+∞
16.7
16
*
G44.2
ICD-10 Finland
Tension-type headache
2.1
16.6
214
1120
M01AH02
ATC
rofecoxib; oral
2.0
16.6
229
1229
M99.1
ICD-10 Finland
Subluxation complex (vertebral)
91.0
16.6
18
*
ABC60
NOMESCO Finland
Decompression of cervical spinal cord
11.7
16.5
30
26
SAA02
NOMESCO Finland
Basic examination of mouth
1.6
16.5
910
7355
M01AB55
ATC
diclofenac, combinations; oral
2.5
16.4
136
579
N06AX11
ATC
mirtazapine; oral
1.7
16.4
475
3256
N02AC04
ATC
dextropropoxyphene; oral
3.2
16.3
87
282
AB5CT
NOMESCO Finland
Blockage of nerv root with CT guidance
12.9
16.2
28
22
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
3.4
16.1
79
241
A28
ICPC
Limited function/disability NOS
1.9
15.8
236
1309
Z3231
NOMESCO Finland
Registered nurse
1.7
15.7
424
2843
J01FA06
ATC
roxithromycin; oral
1.6
15.7
619
4592
7384A
ICD-9 Finland
Other acquired deformity, Acquired spondylolisthesis
+∞
15.6
15
*
M01AE01
ATC
ibuprofen; systemic, rectal
1.8
15.6
1331
11966
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
3.3
15.6
78
242
R53
ICD-10 Finland
Malaise and fatigue
1.8
15.5
317
1956
H02AB06
ATC
prednisolone; systemic
1.6
15.4
702
5380
XF400
NOMESCO Finland
ECG with 12 standard connections
1.9
15.4
263
1530
A02BC03
ATC
lansoprazole; oral
1.6
15.4
453
3111
N01
ICPC
Headache
2.3
15.3
145
660
M51.8
ICD-10 Finland
Other specified intervertebral disc disorders
6.8
15.3
38
57
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
14.9
726
5641
N05BA01
ATC
diazepam; systemic, rectal
1.9
14.7
222
1231
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
3.9
14.7
61
163
M79.7
ICD-10 Finland
Fibromyalgia
3.5
14.6
69
205
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
4.9
14.6
47
98
R20.2
ICD-10 Finland
Paraesthesia of skin
2.5
14.4
112
461
N05BA04
ATC
oxazepam; oral
1.7
14.4
373
2465
A02BA02
ATC
ranitidine; systemic
1.8
14.4
309
1930
R4120
NOMESCO Finland
Occupational therapy
2.5
14.4
117
494
M54.6
ICD-10 Finland
Pain in thoracic spine
2.6
14.3
108
439
R42
ICD-10 Finland
Dizziness and giddiness
1.7
14.2
336
2164
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
2.0
14.2
197
1058
M54.8
ICD-10 Finland
Other dorsalgia
3.2
14.1
76
249
R52.9
ICD-10 Finland
Pain, unspecified
2.3
14.1
135
619
L13
ICPC
Hip symptom/complaint
1.9
14.0
238
1377
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
14.0
641
4887
Z71.8
ICD-10 Finland
Other specified counselling
1.7
13.9
329
2116
7227C
ICD-9 Finland
Intervertebral disk disorders, Intervertebral disk disorder with myelopathy[SYNDROMA ISCHIADICUM]
3.4
13.8
68
209
R02
ICPC
Shortness of breath/dyspnoea
2.0
13.8
198
1079
D01
ICPC
Abdominal pain/cramps general
2.1
13.7
162
818
M43.0
ICD-10 Finland
Spondylolysis
4.5
13.6
47
106
A06AD11
ATC
lactulose; oral
1.9
13.6
224
1285
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.5
13.5
785
6294
L84
ICPC
Back syndrome without radiat pain
3.0
13.4
78
270
S29
ICPC
Skin symptom/complaint other
1.8
13.2
248
1485
ACC51
NOMESCO Finland
Release of median nerve
2.3
13.1
122
550
L01
ICPC
Neck symptom/complaint
1.9
13.0
205
1153
L15
ICPC
Knee symptom/complaint
1.7
12.9
300
1913
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.5
12.8
675
5274
N02AA05
ATC
oxycodone; systemic
1.8
12.7
220
1278
J01DA01
ATC
[U] cefalexin; systemic
1.5
12.6
923
7717
K30
ICD-10 Finland
Functional dyspepsia
2.0
12.6
170
903
WX002
NOMESCO Finland
Sedation and analgesia
1.7
12.6
303
1952
N03AE01
ATC
clonazepam; systemic
2.4
12.6
106
457
M99.2
ICD-10 Finland
Subluxation stenosis of neural canal
+∞
12.5
12
*
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
2.3
12.4
112
498
K02.1
ICD-10 Finland
Caries of dentine
1.5
12.3
782
6334
NA3SA
NOMESCO Finland
Lumbar spine X-ray examination in standing position
11.7
12.3
22
19
J01MA02
ATC
ciprofloxacin; systemic
1.5
12.3
550
4138
J01FF01
ATC
clindamycin; systemic
1.6
12.2
401
2804
WX306
NOMESCO Finland
Lumbar epidural anesthesy
2.4
12.2
101
432
M47.80
ICD-10 Finland
Other spondylosis, multiple sites in spine
3.3
12.2
61
191
R07.3
ICD-10 Finland
Other chest pain
2.1
12.1
144
726
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.5
12.0
738
5924
R51.80
ICD-10 Finland
Headache
1.8
12.0
207
1200
L14
ICPC
Leg/thigh symptom/complaint
2.2
11.9
122
575
J01EA01
ATC
trimethoprim; systemic
1.6
11.9
373
2573
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.5
11.9
593
4556
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.6
11.9
87
348
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.2
11.9
127
614
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
3.1
11.8
65
218
NF1AA
NOMESCO Finland
Hip X-ray examination
2.1
11.7
135
674
J02AC01
ATC
fluconazole; systemic
1.5
11.7
565
4309
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.9
11.7
176
974
M53.2
ICD-10 Finland
Spinal instabilities
7.8
11.6
26
34
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
11.6
307
2026
R60.0
ICD-10 Finland
Localized oedema
1.9
11.6
170
933
N06AB03
ATC
fluoxetine; oral
1.9
11.6
188
1070
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.2
11.5
122
586
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
11.5
309
2049
S21
ICPC
Skin texture symptom/complaint
1.9
11.5
184
1042
7391A
ICD-9 Finland
Nonallopathic lesions, not elsewhere classified, Cervical region
+∞
11.5
11
*
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.7
11.5
239
1472
M16.1
ICD-10 Finland
Other primary coxarthrosis
1.9
11.4
167
915
79199
ICD-8 Finland
Headache
6.1
11.4
30
50
UJD02
NOMESCO Finland
Gastroscopy
2.6
11.3
85
342
AA1AD
NOMESCO Finland
CT of head and brain
1.6
11.3
345
2363
X58
ICD-10 Finland
Exposure to other specified factors
1.8
11.3
202
1187
SPAT1212
SPAT
Extensive examination of musculoskeletal system
2.1
11.3
127
626
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
11.3
415
2970
C07AB07
ATC
bisoprolol; oral
1.5
11.2
669
5312
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
1.8
11.1
203
1203
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.9
10.9
157
855
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
10.9
562
4331
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
3.7
10.7
45
123
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
10.7
232
1444
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.3
10.7
99
447
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.6
10.7
299
1997
M03BX01
ATC
baclofen; systemic
4.1
10.6
40
99
ZXD05
NOMESCO Finland
Urgent procedure
1.5
10.6
447
3292
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
2.4
10.6
88
377
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
2.8
10.6
66
240
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
3.6
10.6
47
135
WX704
NOMESCO Finland
Intubation
2.2
10.5
112
539
M50.9
ICD-10 Finland
Cervical disc disorder, unspecified
7.4
10.5
24
33
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
2.2
10.5
112
541
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
2.2
10.4
110
529
7394A
ICD-9 Finland
Nonallopathic lesions, not elsewhere classified, Sacral region
+∞
10.4
10
*
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.4
10.4
788
6520
WX200
NOMESCO Finland
Interscalenous plexus blockade
4.1
10.2
39
98
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
4.1
10.2
38
94
SPAT1336
SPAT
Request for examination
2.6
10.1
71
277
G04BD12
ATC
mirabegron; oral
1.9
10.1
147
805
M01AX05
ATC
glucosamine; oral
1.6
10.0
294
1986
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
1.8
9.9
169
974
K59.0
ICD-10 Finland
Constipation
2.3
9.9
94
431
WZA00
NOMESCO Finland
Short statement of of health and health related matters
2.2
9.9
96
443
G47.3
ICD-10 Finland
Sleep apnoea
1.6
9.9
291
1969
J45.9
ICD-10 Finland
Asthma, unspecified
1.6
9.9
256
1676
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.8
9.8
161
918
J01CA04
ATC
amoxicillin; systemic
1.5
9.8
1150
10275
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.0
9.8
123
638
AB5BT
NOMESCO Finland
Blockage of nerv root with X-ray guidance
7.4
9.7
22
30
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
9.7
289
1961
J01FA09
ATC
clarithromycin; systemic
1.5
9.7
438
3269
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
2.3
9.6
86
381
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.0
9.6
123
640
S46.0
ICD-10 Finland
Injury of muscle(s) and tendon(s) of the rotator cuff of shoulder
2.0
9.6
127
669
NA1AD
NOMESCO Finland
Cervical spine CT examination
2.8
9.6
60
219
9211
FHL
Exploration or removal of diskusprolapse
3.6
9.6
42
120
N06AB10
ATC
escitalopram; oral
1.6
9.6
272
1824
G56.2
ICD-10 Finland
Lesion of ulnar nerve
2.9
9.5
55
191
R03AK07
ATC
formoterol and budesonide; inhalant
1.6
9.5
263
1751
R03BA02
ATC
budesonide; inhalant
1.6
9.5
246
1610
Z01.2
ICD-10 Finland
Dental examination
1.4
9.4
553
4336
K59.09
ICD-10 Finland
Constipation, unspecified
2.3
9.4
90
412
XF600
NOMESCO Finland
Bloodpressure measurement
2.1
9.4
102
496
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.5
9.4
317
2213
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.6
9.4
242
1580
R01AD09
ATC
mometasone; nasal
1.4
9.3
607
4850
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
2.3
9.3
85
382
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
2.7
9.3
63
242
M15
ICD-10 Finland
Polyarthrosis
2.4
9.3
79
343
EB1AA
SPAT
NA
2.5
9.3
71
293
M47.8
ICD-10 Finland
Other spondylosis
9.6
9.3
18
19
NAG66
NOMESCO Finland
Posterior interbody fusion of lumbar spine, 2 vertebrae
9.6
9.3
18
19
M01AX01
ATC
nabumetone; oral
2.4
9.3
79
344
N17
ICPC
Vertigo/dizziness
1.8
9.2
160
931
W19
ICD-10 Finland
Unspecified fall
1.9
9.2
132
717
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
2.1
9.2
101
495
A02BA04
ATC
nizatidine; systemic
2.0
9.1
121
640
R96
ICPC
Asthma
1.9
9.1
129
700
N03AX09
ATC
lamotrigine; oral
2.5
9.0
68
277
M16.9
ICD-10 Finland
Coxarthrosis, unspecified
2.4
9.0
77
337
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
3.1
9.0
48
160
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.7
8.9
198
1238
G04CA02
ATC
tamsulosin; oral
1.5
8.9
290
2004
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.1
8.9
103
515
2402
FHL
External neurolysis of the nerve and possible alteration of the pathway (nerve pressure)
3.8
8.8
36
97
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
2.1
8.8
94
456
A11
ICPC
Chest pain NOS
2.0
8.8
111
575
N05CF02
ATC
zolpidem; oral
1.6
8.8
245
1629
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
1.8
8.8
151
876
A04
ICPC
Weakness/tiredness general
1.7
8.8
179
1094
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.5
8.7
387
2864
JHB30
NOMESCO Finland
Rubber band ligature of haemorrhoids or prolapse of mucosa
2.2
8.7
89
424
XF404
NOMESCO Finland
Ambulatory ECG
1.9
8.7
130
718
L05
ICPC
Flank/axilla symptom/complaint
2.3
8.7
76
337
TNG34
NOMESCO Finland
Major custom moulded orthopaedic cast, knee or lower leg
4.5
8.7
29
65
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
8.6
546
4325
D20
ICPC
Mouth/tongue/lip symptom/complaint
2.6
8.6
62
248
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.0
8.5
109
567
M19.8
ICD-10 Finland
Other specified arthrosis
2.6
8.5
59
231
U02
ICPC
Urinary frequency/urgency
1.7
8.5
180
1115
M96.0
ICD-10 Finland
Pseudarthrosis after fusion or arthrodesis
90.5
8.4
9
*
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
2.7
8.4
57
220
UJH02
NOMESCO Finland
Anoscopy
2.4
8.4
67
283
P01AB01
ATC
metronidazole; oral, rectal
1.4
8.4
547
4354
J01FA10
ATC
azithromycin; systemic
1.4
8.3
768
6473
N06AA10
ATC
nortriptyline; systemic
3.2
8.3
42
135
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.1
8.3
90
441
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
1.8
8.2
137
783
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.4
8.2
447
3437
R06AX27
ATC
desloratadine; oral
1.5
8.2
346
2527
G57.3
ICD-10 Finland
Lesion of lateral popliteal nerve
4.3
8.2
29
69
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
1.7
8.2
169
1036
M76.8
ICD-10 Finland
Other enthesopathies of lower limb, excluding foot
3.8
8.2
33
89
NFC20
NOMESCO Finland
Secondary implantation of hip prosthesis
4.4
8.1
28
65
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.7
8.1
155
928
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.5
8.1
333
2424
M16
ICD-10 Finland
Coxarthrosis [arthrosis of hip]
2.4
8.1
68
295
ZXD20
NOMESCO Finland
Day surgery
1.7
8.1
182
1144
R35
ICD-10 Finland
Polyuria
2.1
8.0
93
467
S22.3
ICD-10 Finland
Fracture of rib
2.0
8.0
95
481
R05
ICPC
Cough
1.5
8.0
294
2087
K29.3
ICD-10 Finland
Chronic superficial gastritis
2.6
8.0
58
231
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.6
8.0
238
1607
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
1.9
8.0
122
678
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
4.0
8.0
30
76
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
2.3
7.9
70
311
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
1.9
7.9
106
565
XKD00
NOMESCO Finland
Uroflowmetry
1.6
7.8
209
1374
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.1
7.8
89
445
R10.2
ICD-10 Finland
Pelvic and perineal pain
3.3
7.8
37
114
P03
ICPC
Feeling depressed
1.9
7.8
111
603
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
2.2
7.8
74
340
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
1.7
7.8
160
980
ABC26
NOMESCO Finland
Open discectomy of lumbar spine
3.2
7.7
38
120
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.4
7.7
538
4312
K04.0
ICD-10 Finland
Pulpitis
1.8
7.7
122
688
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
2.0
7.7
92
467
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.5
7.7
271
1907
R5110
SPAT
NA
2.9
7.7
45
160
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
2.9
7.7
44
153
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.7
7.7
161
994
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.5
7.6
247
1703
D06
ICPC
Abdominal pain localized other
1.9
7.6
112
616
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
2.5
7.6
59
245
N02AA03
ATC
hydromorphone; systemic, rectal
18.4
7.6
11
6
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.1
7.6
80
384
NAU20
NOMESCO Finland
Removal of internal fixation device from spine or neck
11.9
7.6
13
11
A03FA02
ATC
cisapride; oral, rectal
1.8
7.6
119
670
KMAK
NOMESCO Finland
NA
1.4
7.6
690
5775
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.5
7.5
236
1614
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.1
7.5
80
389
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
2.1
7.5
78
376
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.4
7.5
582
4742
R21
ICPC
Throat symptom/complaint
1.5
7.4
235
1612
L29
ICPC
Musculoskeletal sympt/complt other
1.9
7.4
108
590
QBE20
NOMESCO Finland
Excision and repair of scar or web of skin of trunk
6.5
7.4
18
28
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.5
7.4
243
1680
G55.2
ICD-10 Finland
Nerve root and plexus compressions in spondylosis
7.7
7.4
16
21
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.8
7.4
132
777
TQW40
SPAT
NA
2.6
7.4
51
199
R60.9
ICD-10 Finland
Oedema, unspecified
2.2
7.3
74
352
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
4.0
7.3
27
68
R22.9
ICD-10 Finland
Localized swelling, mass and lump, unspecified
2.0
7.3
93
485
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
1.7
7.2
142
856
A03CA02
ATC
clidinium and psycholeptics; oral
2.0
7.2
91
473
C05AA08
ATC
fluocortolone; rectal, topical
1.6
7.2
204
1361
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.1
7.2
76
369
G54.0
ICD-10 Finland
Brachial plexus disorders
2.9
7.2
42
149
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
2.2
7.2
70
325
M02AA10
ATC
ketoprofen; topical
1.5
7.2
221
1506
C08CA01
ATC
amlodipine; oral
1.4
7.2
483
3840
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
2.9
7.2
41
142
N30.0
ICD-10 Finland
Acute cystitis
1.6
7.2
181
1175
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
1.8
7.1
124
720
WX290
NOMESCO Finland
Other blockade of nerve
1.4
7.1
563
4593
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
2.1
7.1
73
351
R12
ICD-10 Finland
Heartburn
1.9
7.1
94
499
G04BD08
ATC
solifenacin; oral
1.9
7.1
98
529
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.5
7.1
306
2243
XA402
NOMESCO Finland
ENMG
2.8
7.0
42
152
R51
ICD-10 Finland
Headache
2.1
7.0
74
358
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
1.9
7.0
103
567
M51.9
ICD-10 Finland
Intervertebral disc disorder, unspecified
4.0
7.0
26
66
N05AH04
ATC
quetiapine; oral
1.5
7.0
214
1456
E0000UV
ATC
NA
1.4
7.0
520
4202
N05BB01
ATC
hydroxyzine; systemic
2.0
6.9
89
468
N05AA02
ATC
levomepromazine; systemic
2.3
6.9
61
273
G55.1
ICD-10 Finland
Nerve root and plexus compressions in intervertebral disc disorders
4.6
6.9
22
48
D09
ICPC
Nausea
2.4
6.9
55
234
L09
ICPC
Arm symptom/complaint
2.4
6.9
56
242
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
3.2
6.9
34
109
H04.10
ICD-10 Finland
Dry eye syndrome
1.7
6.9
137
833
7290A
ICD-9 Finland
Other disorders of soft tissues, Rheumatism, unspecified and fibrositis
8.3
6.8
14
17
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
2.1
6.8
77
383
UJF30
NOMESCO Finland
Ileoscopy through colon
1.7
6.8
132
797
TNX99
NOMESCO Finland
Other orthopaedic minor procedure
2.6
6.8
48
191
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
2.7
6.8
42
156
7225B
ICD-9 Finland
Intervertebral disk disorders, Degeneration of thoracic or lumbar intervertebral disk[DEGEN DISCI INTERVERT THORAC SEU LUMBOSACR CUM INST]
11.0
6.8
12
11
-1
NOMESCO Finland
NA
1.4
6.8
417
3262
ABC99
NOMESCO Finland
Other decompressive operation on spinal cord or nerve root
16.8
6.7
10
6
SPAT1342
SPAT
Referral to specialised care
4.3
6.7
23
54
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.8
6.7
108
612
M23.8
ICD-10 Finland
Other internal derangements of knee
2.4
6.7
54
231
I10
ICD-10 Finland
Essential (primary) hypertension
1.3
6.7
790
6827
M41.9
ICD-10 Finland
Scoliosis, unspecified
3.7
6.7
27
74
TQW40
NOMESCO Finland
Remowal of suture of skin
1.9
6.7
95
519
NH1BG
NOMESCO Finland
Ankle and foot MRI examination with high intensity magnet
3.3
6.7
31
95
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
1.6
6.7
167
1083
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.7
6.6
143
887
XF402
NOMESCO Finland
ECG with work load test
1.6
6.6
154
977
ZXA10
NOMESCO Finland
Bilateral
1.5
6.6
249
1774
A08
ICPC
Swelling
2.3
6.6
61
277
D07AC01
ATC
betamethasone; topical
1.4
6.6
463
3697
M35.7
ICD-10 Finland
Hypermobility syndrome
4.6
6.6
21
46
ZZH40
NOMESCO Finland
Substitute of bone
4.0
6.6
24
60
S06.0
ICD-10 Finland
Concussion
1.7
6.6
136
834
N02BE51
ATC
paracetamol, combinations excl. psycholeptics; systemic
3.9
6.6
25
65
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
2.6
6.5
44
172
UKC02
NOMESCO Finland
Cystoscopy
1.5
6.5
208
1427
R03AC03
ATC
terbutaline; inhalant
1.6
6.5
185
1236
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.6
6.5
182
1211
NB2AT
NOMESCO Finland
Intra artrial injection of shoulder with ultrasound guidance
3.6
6.5
27
76
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.5
6.5
262
1890
R5140
NOMESCO Finland
Monitoring the use of the aid
1.7
6.5
143
893
U07
ICPC
Urine symptom/complaint other
2.0
6.5
81
421
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
1.9
6.5
85
450
QAE99
SPAT
NA
5.7
6.5
17
30
ND1CG
NOMESCO Finland
Wrist and hand extensive MRI examination with high intensity magnet
5.7
6.5
17
30
C07AA05
ATC
propranolol; systemic
1.5
6.4
248
1772
NF1DA
NOMESCO Finland
X-ray of hips
3.0
6.4
34
115
72880
ICD-8 Finland
Vertebrogenic pain syndrome, Radicula syndrome of lower limbs
3.5
6.4
27
77
R33
ICD-10 Finland
Retention of urine
1.8
6.4
107
615
1225
FHL
Arthroscopy and other therapeutic procedure
3.3
6.4
29
88
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.4
6.3
358
2750
C03CA01
ATC
furosemide; systemic
1.4
6.3
375
2906
WX110
SPAT
NA
2.2
6.3
60
279
M75.9
ICD-10 Finland
Shoulder lesion, unspecified
2.1
6.3
65
314
L60.0
ICD-10 Finland
Ingrowing nail
2.2
6.3
60
280
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
2.9
6.3
36
125
G99.2*M47.9
ICD-10 Finland
Myelopathy in spondylosis
11.1
6.3
11
10
A97
ICPC
No disease
1.5
6.3
188
1270
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
2.3
6.3
54
239
Z09.8
ICD-10 Finland
Follow-up examination after other treatment for other conditions
2.4
6.3
48
200
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
1.7
6.3
141
885
W00
ICD-10 Finland
Fall on same level involving ice and snow
1.7
6.3
138
864
P06
ICPC
Sleep disturbance
1.7
6.3
123
743
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
1.8
6.2
111
652
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
3.2
6.2
30
95
D12
ICPC
Constipation
2.4
6.2
51
221
G99.2*M47.0
ICD-10 Finland
Anterior spinal and vertebral artery compression syndromes
26.8
6.2
8
*
E000001
ATC
NA
1.4
6.2
268
1960
4730A
ICD-9 Finland
Chronic sinusitis, Maxillary
3.5
6.2
27
79
M01AG02
ATC
tolfenamic acid; oral, rectal
1.5
6.2
200
1375
R52.0
ICD-10 Finland
Acute pain
2.5
6.2
45
184
S54
ICPC
Skin, Repair/fix-suture/cast/prosth device
2.4
6.2
50
214
M19.9
ICD-10 Finland
Arthrosis, unspecified
2.3
6.1
53
235
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.4
6.1
338
2587
R01AD08
ATC
fluticasone; nasal
1.4
6.1
367
2848
N05CD07
ATC
temazepam; oral
1.6
6.1
173
1152
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
1.8
6.1
96
544
M50
ICD-10 Finland
Cervical disc disorders
4.7
6.1
19
41
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
1.7
6.1
115
689
SAA03
NOMESCO Finland
Extended examination of mouth
1.3
6.1
487
3958
ZSA00
NOMESCO Finland
Procedure related to previous procedure classified in chapter A
10.1
6.0
11
11
M41.2
ICD-10 Finland
Other idiopathic scoliosis
10.1
6.0
11
11
R05
ICD-10 Finland
Cough
1.4
6.0
255
1857
R06AE07
ATC
cetirizine; oral
1.3
6.0
568
4730
K21
ICD-10 Finland
Gastro-oesophageal reflux disease
2.1
6.0
65
321
Mortality – FinRegistry
↥Association
Association between endpoint M13_BIOMECHLESIO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_BIOMECHLESIO | 1.163 [1.04, 1.3] | 0.01 |
| Birth year | 0.991 [0.98, 1.0] | 0.05 |
During the follow-up period (1.1.1998 — 31.12.2019), 583 out of 3050 females with M13_BIOMECHLESIO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_BIOMECHLESIO | 1.207 [1.07, 1.36] | 0.002 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 596 out of 2252 males with M13_BIOMECHLESIO died.
Mortality risk
Mortality risk for people of age
years, who have M13_BIOMECHLESIO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.088% | 0.179% |
| 5 | 0.625% | 1.357% |
| 10 | 1.566% | 3.251% |
| 15 | 3.048% | 6.271% |
| 20 | 5.052% | 10.661% |
Relationships between endpoints
↥Index endpoint: M13_BIOMECHLESIO – Biomechanical lesions, not elsewhere classified
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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