primary myelofibrosis: Myelofibrosis with myeloid metaplasia is a myeloproliferative disease with annual incidence of approximately 1 case per 100,000 individuals and age at diagnosis around 60 (an increased prevalence is noted in Ashkenazi Jews). Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy, hepatomegaly, portal hypertension.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
1437 |
4. Check minimum number of eventsNone |
1437 |
5. Include endpointsNone |
1437 |
6. Filter based on genotype QC (FinnGen only) |
1403 |
Control definitions (FinnGen only)
- Control exclude
- C3_CANCER, C3_CANCER_WIDE
Extra metadata
- First used in FinnGen datafreeze
- DF8
Similar endpoints
↥List of similar endpoints to
Essential (haemorrhagic) thrombocythaemia
based on the number of shared cases.
Similar with more cases:
- Myeloproliferative diseases
- Liquid cancers, helper endpoint
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7386 | 4434 | 2920 |
| Only index persons | 6776 | 4112 | 2664 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.11 | 0.13 | 0.08 |
| Only index persons | 0.13 | 0.15 | 0.10 |
| Median age at first event (years) | |||
| Whole population | 65.45 | 66.09 | 64.42 |
| Only index persons | 64.72 | 65.35 | 63.73 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1403 | 831 | 572 |
| Unadjusted period prevalence (%) | 0.28 | 0.29 | 0.26 |
| Median age at first event (years) | 63.41 | 62.30 | 65.01 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1437
- Matched controls
- 14370
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
621.0
307.7
1043
61
D47.3
ICD-10 Finland
Essential (haemorrhagic) thrombocythaemia
+∞
307.7
1377
*
9962/3-C42.1
ICD-O-3
Essential thrombocythemia of bone marrow
+∞
307.7
457
*
XW000
NOMESCO Finland
Bone marrow biopsy
51.1
307.7
531
163
D75.2
ICD-10 Finland
Essential thrombocytosis
732.7
307.7
646
16
D45
ICD-10 Finland
Polycythaemia vera
51.0
307.7
239
56
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
99.9
307.7
213
25
L01XX05
ATC
hydroxycarbamide; oral
625.7
307.7
973
48
D75.9
ICD-10 Finland
Disease of blood and blood-forming organs, unspecified
76.0
278.4
150
22
L01XX35
ATC
anagrelide; oral
2187.2
212.9
201
*
L03AB05
ATC
interferon alfa-2b; parenteral
1604.6
149.7
143
*
D47.1
ICD-10 Finland
Chronic myeloproliferative disease
190.0
148.8
153
9
TPH00
NOMESCO Finland
Phlebotomy
33.0
125.3
81
26
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
35.9
119.0
75
22
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.3
104.9
322
898
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
55.9
103.9
59
11
9950/3-C42.1
ICD-O-3
Polycythemia vera of bone marrow
37.4
98.0
61
17
SPAT1074
SPAT
Venesection
26.6
95.2
66
26
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
16.1
86.8
75
49
L03AB04
ATC
interferon alfa-2a; parenteral
856.2
83.4
81
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.4
79.0
225
586
B99
ICPC
Blood/lymph/spleen disease other
33.8
76.5
49
15
H02AB02
ATC
dexamethasone; systemic
11.1
73.0
79
75
9961/3-C42.1
ICD-O-3
Primary myelofibrosis of bone marrow
375.6
72.3
72
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
67.2
64
*
9960/3-C42.1
ICD-O-3
Myeloproliferative neoplasm, NOS, of bone marrow
147.0
66.5
70
5
C61
ICD-10 Finland
Malignant neoplasm of prostate
645.6
63.3
62
*
212
Kela drug reimbursment
Gout
8.9
61.5
78
92
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
60.9
58
*
130
Kela drug reimbursment
Malignant tumour
+∞
57.7
55
*
R79.8
ICD-10 Finland
Other specified abnormal findings of blood chemistry
17.3
56.7
47
28
WW500
NOMESCO Finland
Blood transfusion
7.7
55.9
80
109
115
Kela drug reimbursment
Breast cancer
+∞
54.5
52
*
PJA12
NOMESCO Finland
Sentinel node biopsy
275.6
52.5
53
*
M04AA01
ATC
allopurinol; systemic
2.9
51.7
281
1096
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
5.1
46.7
102
212
R79.9
ICD-10 Finland
Abnormal finding of blood chemistry, unspecified
13.8
46.1
43
32
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
+∞
42.9
41
*
B03XA01
ATC
erythropoietin; parenteral
17.1
42.0
35
21
174
Kela drug reimbursment
Ruxolitinib
147.6
41.0
43
*
B03XA02
ATC
darbepoetin alfa; parenteral
7.9
40.6
56
73
D47.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue, unspecified
77.5
40.1
45
6
A04AA02
ATC
granisetron; systemic, transdermal
77.5
40.1
45
6
HAB40
NOMESCO Finland
Wedge excision of mammary gland
14.0
40.0
37
27
B01AB05
ATC
enoxaparin; parenteral
2.1
36.4
490
2832
374
Kela drug reimbursment
Ruxolitinib
130.0
35.9
38
*
L01EJ01
ATC
ruxolitinib; oral
130.0
35.9
38
*
116
Kela drug reimbursment
Prostate cancer
+∞
33.5
32
*
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
+∞
33.5
32
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
33.3
706
4754
A04AA01
ATC
ondansetron; systemic, rectal
4.8
33.0
76
165
Z51.5
ICD-10 Finland
Palliative care
4.2
32.2
88
219
L03AA04, ,
ATC
324.0
32.0
32
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.0
30.6
145
517
HAC20
NOMESCO Finland
Total mastectomy
147.9
27.7
29
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
147.9
27.7
29
*
L02BG04
ATC
letrozole; oral
9.4
27.5
33
36
L01BC06
ATC
capecitabine; oral
+∞
26.1
25
*
WZC00
NOMESCO Finland
Treatment plan or consultation
1.9
25.9
429
2610
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
95.2
25.7
28
*
B01AC14
ATC
[U] anagrelide
+∞
25.1
24
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
254.4
24.7
25
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
43.7
24.6
30
7
A03FA01
ATC
metoclopramide; systemic, rectal
2.3
24.2
210
1004
L57.0
ICD-10 Finland
Actinic keratosis
2.6
24.2
154
640
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
24.0
23
*
HA003
NOMESCO Finland
Radiotherapy after partial ablation of mammary gland
+∞
24.0
23
*
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
24.1
23.5
33
14
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
8.9
22.5
28
32
L03AA02
ATC
filgrastim; parenteral
45.8
22.4
27
6
JN4BD
NOMESCO Finland
Extensive body CT
3.2
22.4
91
296
8070/3-C44.9
ICD-O-3
Squamous cell carcinoma, NOS, of skin, NOS
+∞
21.9
21
*
WF002
NOMESCO Finland
Radical radiotherapy
29.6
21.9
29
10
D75.8
ICD-10 Finland
Other specified diseases of blood and blood-forming organs
81.4
21.7
24
*
XX3DW
NOMESCO Finland
Time consuming IT work
3.1
21.7
95
323
TPH00, ,
SPAT
34.4
21.2
27
8
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
61.0
20.9
24
*
C92.0
ICD-10 Finland
Acute myeloblastic leukaemia [AML]
+∞
20.9
20
*
L01XE18
ATC
[U] ruxolitinib
213.0
20.6
21
*
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
5.9
20.2
36
62
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
5.1
20.0
42
84
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
+∞
19.8
19
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
106.5
19.6
21
*
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
202.7
19.6
20
*
C50.99
ICD-10 Finland
Breast, unspecified
202.7
19.6
20
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.1
19.5
84
283
Z2221
NOMESCO Finland
Medical doctor
1.8
19.3
383
2430
ZX120
NOMESCO Finland
Intravenous
2.6
19.2
115
463
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
+∞
18.8
18
*
B01AB10
ATC
tinzaparin; parenteral
2.5
18.8
128
548
C90.0
ICD-10 Finland
Multiple myeloma
192.4
18.6
19
*
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.7
18.5
102
394
Z3231
NOMESCO Finland
Registered nurse
1.8
18.4
372
2370
JN4AD
NOMESCO Finland
Body CT examination
2.8
18.0
96
364
L02BB03
ATC
bicalutamide; oral
+∞
17.7
17
*
8140/3-C20.9
ICD-O-3
Adenocarcinoma, NOS, of rectum, NOS
+∞
17.7
17
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
17.7
17
*
B74
ICPC
Malignant neoplasm blood other
64.1
16.8
19
*
XW4XT
NOMESCO Finland
Biopsy of other inner organ with radiological guidance guidance
64.1
16.8
19
*
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
+∞
16.7
16
*
C50.40
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, no histological veryfication
+∞
16.7
16
*
XW000, ,
SPAT
91.1
16.6
18
*
Y77
ICPC
Malignant neoplasm prostate
171.9
16.5
17
*
ZZR00
NOMESCO Finland
Flap of skin
15.5
16.2
26
17
L03AA13
ATC
pegfilgrastim; parenteral
60.7
15.8
18
*
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
+∞
15.6
15
*
9861/3-C42.1
ICD-O-3
Acute myeloid leukemia, NOS, of bone marrow
+∞
15.6
15
*
PJ5AN
NOMESCO Finland
Localisation of sentinell lymphnode with isotope imaging
+∞
15.6
15
*
D47.0
ICD-10 Finland
Histiocytic and mast cell tumours of uncertain and unknown behaviour
86.0
15.6
17
*
XX7BT
NOMESCO Finland
Radioactive phosphorus therapy
86.0
15.6
17
*
C44.30
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face without histology
161.7
15.5
16
*
R04.0
ICD-10 Finland
Epistaxis
2.2
15.5
130
609
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
15.1
425
2935
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
2.7
14.9
79
299
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.1
14.7
154
787
WB203
NOMESCO Finland
Simple adjuvant hormone therapy of malignancy
+∞
14.6
14
*
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
3.5
14.2
49
144
L02BA01
ATC
tamoxifen; oral
42.9
14.1
17
*
HA1AA
NOMESCO Finland
X-ray mammography
3.1
13.9
57
187
B01AB04
ATC
dalteparin; parenteral
2.7
13.9
74
281
R4110
NOMESCO Finland
Physiotherapy
1.6
13.8
364
2463
C44.11
ICD-10 Finland
Basocellular carcinoma of the skin of the eyelids including the corner of the eye
+∞
13.6
13
*
L02BG03
ATC
anastrozole; oral
+∞
13.6
13
*
L01AB01
ATC
busulfan; systemic
+∞
13.6
13
*
NK6AN
NOMESCO Finland
Total body bone isotope imaging
34.4
13.5
17
5
KE1AT
NOMESCO Finland
Biopsy of prostata with ultrasoudnguidance
3.9
13.5
40
106
Z03.1
ICD-10 Finland
Observation for suspected malignant neoplasm
6.4
13.3
22
35
R50.9
ICD-10 Finland
Fever, unspecified
1.9
13.3
186
1051
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.2
13.3
110
513
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
40.5
13.2
16
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
13.0
305
2001
ZX112
NOMESCO Finland
Subcutaneous
6.2
12.9
22
36
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.7
12.9
41
114
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
4.1
12.9
35
87
S97
ICPC
Chronic ulcer skin
2.2
12.8
106
494
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
12.7
281
1814
C50.90
ICD-10 Finland
Malignant tumor in other or unspecified location in mammary gland without histology
+∞
12.5
12
*
8500/3-C50.4
ICD-O-3
Infiltrating duct carcinoma, NOS, of upper-outer quadrant of breast
+∞
12.5
12
*
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
+∞
12.5
12
*
2387B
ICD-9 Finland
Neoplasm of uncertain behaviour of other and unspecified sites and tissues, Other lymphatic and haematopoietic tissues[THROMBOCYTHAEMIA IDIOPATHICA]
+∞
12.5
12
*
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
+∞
12.5
12
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
12.5
12
*
GDC01
NOMESCO Finland
Thoracoscopic lobectomy of lung
+∞
12.5
12
*
WF004
NOMESCO Finland
Palliative radiotherapy
131.1
12.5
13
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.5
12.2
450
3280
L02AE02
ATC
leuprorelin; implant, parenteral
8.8
12.0
25
29
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
9.4
12.0
24
26
D05.1
ICD-10 Finland
Intraductal carcinoma in situ
65.5
11.6
13
*
C50.81
ICD-10 Finland
Overall malignant tumor of the mammary gland, ductal tumor
+∞
11.5
11
*
2387X
ICD-9 Finland
Neoplasm of uncertain behaviour of other and unspecified sites and tissues, Other lymphatic and haematopoietic tissues[STATUS LYMPHO- ET MYELOPROLIFERATIVUS NUD]
+∞
11.5
11
*
KEC00
NOMESCO Finland
Retropubic radical prostatectomy
+∞
11.5
11
*
C34.12
ICD-10 Finland
Malignant tumor of the anterior, bronchial or pulmonary adenocarcinoma
+∞
11.5
11
*
C44.41
ICD-10 Finland
Basocellular carcinoma of the skin of the scalp and neck
121.0
11.4
12
*
J01MA12
ATC
levofloxacin; systemic
1.7
11.4
238
1510
TPH07
NOMESCO Finland
Cathetrisation of artery
2.0
11.3
137
736
J01DB01
ATC
cefalexin; oral
1.6
11.3
1108
9807
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
2.5
11.2
69
282
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.9
11.2
146
805
TNE20
NOMESCO Finland
Bone marrow aspiration, pelvis
20.2
11.1
16
8
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.2
11.0
95
451
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
4.7
11.0
25
54
WZC30
NOMESCO Finland
Teaching
1.8
10.9
164
946
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
5.6
10.7
20
36
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
21.6
10.7
15
7
UJF32
NOMESCO Finland
Coloscopy
1.6
10.7
344
2423
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
60.5
10.6
12
*
B28
ICPC
Limited function/disability (B)
9.2
10.5
21
23
A02BC02
ATC
pantoprazole; systemic
1.5
10.5
921
7894
C03CA01
ATC
furosemide; systemic
1.5
10.5
435
3233
C50
ICD-10 Finland
Malignant neoplasm of breast
110.8
10.4
11
*
D75
ICD-10 Finland
Other diseases of blood and blood-forming organs
110.8
10.4
11
*
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
+∞
10.4
10
*
8090/3-C44.4
ICD-O-3
Basal cell carcinoma, NOS, of skin of scalp and neck
+∞
10.4
10
*
C50.51
ICD-10 Finland
Malignant tumor of the lower outer quadrant of the mammary gland, ductal tumor
+∞
10.4
10
*
C67.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bladder
+∞
10.4
10
*
ZXE00
NOMESCO Finland
One hour or less
1.5
10.3
486
3700
WX302
NOMESCO Finland
Thoracal epidural anesthesy
3.3
10.3
39
122
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
1.9
10.3
133
731
THW99
NOMESCO Finland
Other minor procedure in surgery of mammary gland
18.9
10.3
15
8
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
10.3
312
2167
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
3.7
10.1
32
89
N02AA05
ATC
oxycodone; systemic
1.7
10.1
196
1217
QAE99
NOMESCO Finland
Other excision or repair surgery of skin and subcutaneous tissue in head and neck
4.1
10.0
27
67
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
3.2
9.9
38
120
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
20.2
9.8
14
7
ZYC05
NOMESCO Finland
Non-real-time text-based remote communication
4.1
9.7
26
64
X76
ICPC
Malignant neoplasm breast female
55.4
9.7
11
*
C20.90
ICD-10 Finland
Malignant tumor of the rectum without histology
55.4
9.7
11
*
ZXC50
NOMESCO Finland
Cryotherapy
3.1
9.6
39
128
C44.21
ICD-10 Finland
Basocellular carcinoma of the skin of the outer ear and the outer ear canal
100.7
9.4
10
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
100.7
9.4
10
*
S77
ICPC
Malignant neoplasm of skin
30.2
9.4
12
*
C44.61
ICD-10 Finland
Basocellular carcinoma of the skin of the upper extremity including the shoulder
30.2
9.4
12
*
9823/3-C42.1
ICD-O-3
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma of bone marrow
+∞
9.4
9
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
9.4
9
*
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
+∞
9.4
9
*
KEC01
NOMESCO Finland
Percutaneous endoscopic radical prostatectomy
+∞
9.4
9
*
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
9.4
9
*
C50.91
ICD-10 Finland
Malignant tumor in another specified localization in ductal mammary gland
+∞
9.4
9
*
C50.42
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, lobular tumor
+∞
9.4
9
*
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
+∞
9.4
9
*
8120/3-C67.9
ICD-O-3
Transitional cell carcinoma, NOS, of bladder, NOS
+∞
9.4
9
*
DAB10
NOMESCO Finland
Partial excision of auricle
+∞
9.4
9
*
C50.49
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, other or undeterminated histology
+∞
9.4
9
*
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.0
9.3
101
524
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
2.8
9.0
45
166
D73.5
ICD-10 Finland
Infarction of spleen
24.2
8.9
12
5
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
24.2
8.9
12
5
ZXE10
NOMESCO Finland
More than one and less than three hours
1.4
8.9
443
3391
UJF30
NOMESCO Finland
Ileoscopy through colon
1.8
8.8
133
769
WVA20
NOMESCO Finland
Medicine administration
3.1
8.7
36
119
JN4CD
NOMESCO Finland
Very extensive body CT
3.9
8.7
25
65
HAB50
NOMESCO Finland
Partial excision of mammary gland with reconstructive operation
50.3
8.7
10
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.5
8.6
258
1779
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.7
8.6
150
904
ZX090
NOMESCO Finland
Other technic of radiotherapy
20.2
8.5
12
6
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.6
8.4
182
1161
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
90.6
8.4
9
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.1
8.4
79
389
C67.2
ICD-10 Finland
Malignant neoplasm: Lateral wall of bladder
+∞
8.3
8
*
HA013
NOMESCO Finland
Radiotherapy after total ablation of mammary gland
+∞
8.3
8
*
C92.1
ICD-10 Finland
Chronic myeloid leukaemia [CML], BCR/ABL-positive
+∞
8.3
8
*
8520/3-C50.9
ICD-O-3
Lobular carcinoma, NOS, of breast, NOS
+∞
8.3
8
*
C50.21
ICD-10 Finland
Malignant tumor of the upper inner quadrant of the mammary gland,ductal tumor
+∞
8.3
8
*
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.7
8.3
169
1061
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
3.7
8.3
26
72
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.1
8.2
73
351
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
14.6
8.2
13
9
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.9
8.1
103
563
AA1BD
NOMESCO Finland
Extensive CT of head and brain
3.3
8.1
30
93
S29
ICPC
Skin symptom/complaint other
1.5
7.7
245
1709
N02BE01
ATC
paracetamol; systemic, rectal
1.5
7.7
1222
11310
DKW00
NOMESCO Finland
Cauterisation of mucosa of nose
4.4
7.7
19
44
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.8
7.7
114
655
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
2.9
7.7
35
123
D69.1
ICD-10 Finland
Qualitative platelet defects
25.1
7.6
10
*
308
Kela drug reimbursment
Alprostadil, sildenafil and combination product containing aviptadil and phentolamine
25.1
7.6
10
*
D06BB10
ATC
imiquimod; topical
2.2
7.5
63
296
KCD02
NOMESCO Finland
Transurethral resection of bladder
10.1
7.5
14
14
ZYC01
NOMESCO Finland
Remote contact by phone
2.0
7.5
75
378
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.6
7.5
202
1360
R51.80
ICD-10 Finland
Headache
1.6
7.5
193
1286
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
2.1
7.5
72
358
C67.9
ICD-10 Finland
Malignant neoplasm: Bladder, unspecified
80.5
7.4
8
*
D41.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Kidney
3.8
7.4
22
59
Z3226
NOMESCO Finland
Physiotherapist
1.5
7.3
227
1574
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
1.8
7.3
112
650
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
7.3
636
5305
8140/3-C34.1
ICD-O-3
Adenocarcinoma, NOS, of upper lobe, lung
+∞
7.3
7
*
ZX080
NOMESCO Finland
Image guided radiotherapy
+∞
7.3
7
*
C50.11
ICD-10 Finland
Malignant tumor of the central part of the mammary gland,ductal tumor
+∞
7.3
7
*
C43.52
ICD-10 Finland
Malignant melanoma on the torso: 'superficial spreading' type
+∞
7.3
7
*
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
+∞
7.3
7
*
8097/3-C44.9
ICD-O-3
Basal cell carcinoma, nodular of skin, NOS
+∞
7.3
7
*
A79
ICPC
Malignancy NOS
+∞
7.3
7
*
C54.11
ICD-10 Finland
Adenocarcinoma of the endometrium
+∞
7.3
7
*
D46.7
ICD-10 Finland
Other myelodysplastic syndromes
9.4
7.3
14
15
TQW99
NOMESCO Finland
Other minor procedure on skin
2.2
7.2
56
255
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.5
7.2
267
1920
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.2
7.1
57
264
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
3.3
7.0
26
81
I26.0
ICD-10 Finland
Pulmonary embolism with mention of acute cor pulmonale
2.7
7.0
35
130
J01MA02
ATC
ciprofloxacin; systemic
1.4
6.9
488
3931
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.5
6.8
216
1503
S18
ICPC
Laceration/cut
1.3
6.8
572
4729
B04
ICPC
Blood symptom/complaint
6.7
6.8
16
24
D75.0
ICD-10 Finland
Familial erythrocytosis
16.8
6.7
10
6
N02AX02
ATC
tramadol; systemic, rectal
1.3
6.7
544
4471
C44.71
ICD-10 Finland
Basocellular carcinoma of the skin of the lower extremity including the hip
22.6
6.7
9
*
I81
ICD-10 Finland
Portal vein thrombosis
8.7
6.6
13
15
JFF23
NOMESCO Finland
Transversostomy
10.1
6.5
12
12
A04AD12
ATC
aprepitant; systemic
70.2
6.4
7
*
KE3AT
NOMESCO Finland
Transrectal gold marker implantation in prostate under ultrasound guidance
70.2
6.4
7
*
ZXD05
NOMESCO Finland
Urgent procedure
1.4
6.4
363
2815
JAH01
NOMESCO Finland
Laparoscopy
2.3
6.4
45
197
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.4
6.3
333
2551
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
11.1
6.3
11
10
WF001
NOMESCO Finland
Preoperative radiotherapy
+∞
6.3
6
*
C34.1
ICD-10 Finland
Malignant neoplasm: Upper lobe, bronchus or lung
+∞
6.3
6
*
C44.81
ICD-10 Finland
Overall basocellular carcinoma of the skin
+∞
6.3
6
*
WB123
NOMESCO Finland
Demanding adjuvant cytostatic therapy
+∞
6.3
6
*
9732/3-C42.1
ICD-O-3
Plasma cell myeloma of bone marrow
+∞
6.3
6
*
128
Kela drug reimbursment
Cancers of female genital organs
+∞
6.3
6
*
C78.6
ICD-10 Finland
Secondary malignant neoplasm of retroperitoneum and peritoneum
+∞
6.3
6
*
B73
ICPC
Leukaemia
+∞
6.3
6
*
B01AA03
ATC
warfarin; systemic
1.4
6.2
271
2006
HAE10
NOMESCO Finland
Reconstruction of breast using graft or flap
26.8
6.2
8
*
JN3AD
NOMESCO Finland
Abdominal CT examination
1.7
6.2
124
776
ZXC20
NOMESCO Finland
Use of chemical agents
3.2
6.2
24
77
Z31.5
ICD-10 Finland
Genetic counselling
2.3
6.1
43
188
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
7.7
6.1
13
17
R86.0
ICD-10 Finland
Abnormal findings in specimens from male genital organs, abnormal level of enzymes
3.8
6.1
18
48
XF400
NOMESCO Finland
ECG with 12 standard connections
1.5
6.1
202
1420
WW200
NOMESCO Finland
Immunization
2.6
6.1
34
134
DHB00
NOMESCO Finland
Excision of lesion of external nose
8.6
6.1
12
14
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
1244
5102
11.71
309.05
18.1
5.6
—
—
—
0
0
372
191
25.93
307.65
1.3
1.2
29.82
19.73
u/l
0.65
333
164
508
125
62.32
307.65
1.0
1.0
—
—
—
0
0
598
921
10.41
307.65
3.7
2.2
73.67
69.44
e9/l
1.79
434
711
718
1255
10.44
307.65
3.5
2.2
1.81
1.77
%
0.46
637
1109
438
118
52.95
307.65
1.3
1.4
—
—
—
0
0
1045
1050
33.82
307.65
9.2
2.5
279.88
234.99
u/l
14.09
1013
972
1175
4977
8.46
266.30
16.4
5.5
1.02
0.68
%
36.06
1144
4589
1188
5126
8.60
262.44
16.6
5.5
2.69
2.95
%
4.54
1160
4737
1190
5147
8.63
262.05
17.6
5.7
8.49
8.64
%
1.00
1161
4760
1233
5519
9.69
261.66
15.1
5.3
0.60
0.59
e9/l
0.98
1145
4732
1233
5533
9.65
260.45
15.2
5.3
0.07
0.04
e9/l
29.27
1146
4747
1242
5666
9.78
255.92
15.4
5.3
1.90
1.87
e9/l
0.30
1167
4968
1196
5268
8.57
255.74
17.2
5.6
25.97
27.61
%
6.40
1169
4891
1243
5729
9.66
251.44
16.3
5.5
0.21
0.20
e9/l
1.00
1159
4993
1185
5226
8.23
251.23
15.8
5.4
59.68
57.52
%
9.30
1156
4848
582
1433
6.15
238.73
2.6
2.5
24.00
23.05
%
0.78
514
1215
1262
6137
9.67
233.11
21.3
6.2
4.65
4.26
e9/l
2.72
1186
5271
862
3087
5.48
225.56
4.1
2.4
1740.05
6942.48
umol/l
4.82
802
2660
589
1554
5.73
221.43
2.5
2.4
2.35
2.33
g/l
0.51
563
1436
610
1711
5.46
212.30
2.6
2.4
14.16
13.14
umol/l
2.55
585
1585
1107
5420
5.54
182.11
8.9
3.7
11.19
11.77
umol/l
0.75
1074
5061
351
756
5.82
160.87
9.1
3.7
1.15
0.52
%
4.63
165
179
344
784
5.45
147.14
9.1
3.9
0.19
0.04
%
3.85
155
166
204
275
8.48
146.24
2.6
2.2
3.32
3.46
g/l
0.70
194
255
915
4762
3.54
116.10
3.8
2.7
126.08
118.82
ug/l
0.41
857
4350
921
4938
3.41
108.64
19.9
8.2
0.04
0.00
e9/l
2.62
805
4003
1283
8710
5.41
101.45
14.9
5.3
79.84
75.54
u/l
2.90
1253
8041
217
481
5.14
93.66
1.8
1.7
1.09
1.49
g/l
7.35
183
416
637
2951
3.08
92.64
2.6
2.2
3.51
2.94
mg/l
3.20
552
2497
104
106
10.50
91.75
9.5
2.8
1.65
1.25
%
0.49
91
85
163
291
6.19
88.97
2.2
2.0
95.00
88.89
%
2.50
137
284
947
5659
2.97
83.17
7.2
5.4
1.22
1.22
mmol/l
0.18
795
4836
855
5104
2.67
70.59
6.6
5.0
1.22
1.21
mmol/l
4.24
785
4547
109
182
6.40
63.25
6.3
3.5
60.57
57.67
%
1.53
109
182
532
2662
2.59
61.27
5.0
3.4
86.19
88.34
%
1.08
501
2589
122
261
5.02
54.12
3.3
2.5
1.26
1.59
mg/l
4.69
117
230
125
275
4.88
53.64
2.6
2.2
174.19
186.11
%
0.67
118
260
821
5208
2.34
53.57
2.3
2.0
92.06
94.92
pmol/l
0.92
467
2549
65
73
9.28
53.13
8.9
2.9
63.01
55.40
%
2.02
52
56
115
239
5.14
52.73
1.7
1.5
—
—
—
0
0
551
2979
2.38
51.80
1.8
1.5
21.28
20.90
nmol/l
0.23
493
2479
757
4728
2.27
50.05
5.4
3.7
35.93
35.71
g/l
0.50
711
4333
275
1143
2.74
44.40
4.0
2.1
7.14
7.64
umol/l
0.14
251
983
228
920
2.76
38.64
2.4
1.6
66.57
67.19
g/l
0.55
203
824
348
1723
2.35
38.23
2.6
2.0
31.26
29.92
s
4.21
328
1663
332
1626
2.35
37.30
3.0
2.5
0.83
0.82
mmol/l
0.49
318
1497
928
6810
2.02
34.58
5.5
4.2
6.57
6.79
mmol/l
2.86
895
6342
422
2457
2.02
29.65
2.0
1.7
1.09
1.20
mg/l
0.30
330
1872
1100
8797
2.07
29.50
4.9
4.2
12.51
12.14
mm/h
0.32
1028
8114
109
346
3.33
27.95
2.7
1.4
0.05
0.00
g/l
0.47
94
315
30
28
10.92
27.83
6.8
2.1
—
—
—
0
0
104
328
3.34
26.93
2.5
1.4
0.00
0.00
g/l
-0.00
89
298
103
324
3.35
26.78
2.5
1.4
0.00
0.00
g/l
-0.00
89
297
114
389
3.10
25.91
2.8
1.4
1.21
0.44
g/l
1.73
97
334
122
435
2.97
25.68
2.6
1.4
3.00
2.96
g/l
0.20
105
382
109
370
3.11
24.99
2.4
1.4
39.02
37.93
g/l
1.10
93
317
402
2419
1.92
24.97
1.8
1.7
1039.65
1166.68
nmol/l
2.17
293
1815
121
438
2.92
24.78
2.3
1.4
10.91
10.57
g/l
0.36
105
384
126
468
2.85
24.62
2.5
1.4
3.46
3.71
g/l
1.48
110
415
126
468
2.85
24.62
2.5
1.4
—
—
—
0
0
126
468
2.85
24.62
2.5
1.4
6.83
7.46
g/l
3.70
110
415
272
1435
2.10
24.46
3.9
4.8
1.07
1.02
mmol/l
1.98
254
1308
28
5
57.05
24.08
1.0
1.0
—
—
—
0
0
102
341
3.14
23.99
3.0
1.5
35.22
33.50
mg/l
0.14
91
279
1321
11638
2.67
23.93
25.1
12.7
20.34
22.98
mg/l
2.42
1096
8986
102
342
3.13
23.87
3.0
1.5
70.58
42.07
mg/l
0.41
91
281
524
3471
1.80
23.73
4.1
2.6
33.74
32.82
u/l
0.15
503
3292
98
327
3.14
23.12
3.1
1.5
1.17
1.35
ratio
—
10
30
738
5424
1.74
23.08
19.0
16.9
1.31
1.33
inr
0.27
244
1555
135
562
2.55
21.04
2.9
1.4
4.26
2.72
ug/l
0.93
97
418
163
744
2.34
20.77
2.4
2.2
10.16
10.79
g/l
1.26
146
678
531
3668
1.71
19.93
2.8
2.1
2.34
2.36
mmol/l
1.50
464
3059
338
2113
1.78
17.73
3.3
2.2
2.44
2.45
mmol/l
0.43
292
1804
32
56
5.82
17.63
2.1
1.4
—
—
—
0
0
32
56
5.82
17.63
2.1
1.4
—
—
—
0
0
447
3039
1.68
17.28
3.6
2.9
0.38
0.41
e6/l
0.09
335
2312
132
599
2.33
16.98
2.0
1.4
1.38
1.21
g/l
0.46
116
546
149
721
2.19
16.43
1.7
1.5
—
—
—
0
0
474
3320
1.64
16.09
3.6
3.0
68.43
80.52
e6/l
0.11
359
2541
179
939
2.04
15.96
4.2
6.4
9.38
10.26
mmol/l
0.92
168
891
53
152
3.58
15.91
4.0
5.6
1502.33
500.45
iu/ml
—
6
22
296
1836
1.77
15.75
1.9
1.8
—
—
—
0
0
167
861
2.06
15.60
3.4
2.9
1.22
1.23
mmol/l
0.55
141
718
369
2453
1.68
15.22
4.3
2.0
—
—
—
0
0
1341
12314
2.33
14.90
25.8
15.2
139.54
139.76
mmol/l
2.30
1320
11965
1343
12346
2.34
14.78
27.5
15.3
4.00
3.98
mmol/l
1.97
1321
11977
642
4909
1.56
14.67
4.4
2.3
—
—
—
0
0
536
3936
1.58
14.63
4.1
3.5
128.60
119.45
e6/l
0.08
382
2748
51
157
3.33
13.76
1.2
1.2
2.00
3.20
u/ml
0.32
23
45
716
5683
1.52
13.33
4.9
5.0
0.00
0.00
estimate
-0.00
170
962
722
5746
1.52
13.24
3.6
3.7
0.00
0.01
estimate
1.08
169
940
715
5688
1.51
13.07
3.6
3.7
0.00
0.00
estimate
0.99
182
1048
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
76
313
2.51
12.12
3.0
2.9
0.29
0.36
u/ml
1.71
44
191
47
152
3.16
11.75
1.2
1.2
4.91
5.46
u/ml
0.07
22
65
336
2323
1.58
11.39
2.8
2.4
5.35
5.94
e6/l
0.31
306
2073
304
2058
1.61
11.25
1.5
1.3
2.36
2.57
g/l
0.76
178
1185
21
38
5.59
11.18
1.4
2.6
—
—
—
0
0
47
157
3.06
11.14
1.0
1.1
—
—
—
0
0
494
3731
1.49
11.10
3.1
3.0
2640.17
1355.97
ng/l
2.20
435
3175
262
1722
1.64
10.91
3.2
2.7
1.98
3.00
e6/l
1.08
127
927
342
2408
1.55
10.62
3.9
3.9
962.28
492.02
ng/l
0.28
275
1946
1245
11385
1.70
10.53
5.2
4.2
1.26
1.29
mmol/l
1.10
1180
10315
1341
12545
2.03
10.43
22.3
9.0
24.97
25.32
u/l
0.34
1321
11992
127
685
1.94
10.39
1.6
1.6
—
—
—
0
0
207
1297
1.70
10.32
1.7
1.7
—
—
—
0
0
206
1293
1.69
10.20
1.8
1.8
—
—
—
0
0
1218
11101
1.64
10.13
25.6
11.6
77.74
77.54
ml/min/173m2
0.13
1063
8916
146
839
1.82
9.82
2.1
2.0
0.20
0.20
g/l
0.11
129
763
161
957
1.77
9.67
2.2
2.1
32.12
34.79
u/l
0.44
141
803
880
7609
1.40
8.65
4.7
4.5
7183.89
2278.43
e6/l
—
9
113
836
7178
1.39
8.49
3.4
3.0
56.67
46.21
u/l
2.96
796
6599
116
651
1.85
8.42
3.1
3.0
4.33
4.53
pmol/l
1.59
92
561
1198
10990
1.54
8.42
5.4
4.8
2.04
2.08
mu/l
0.13
1123
9974
268
1873
1.53
8.42
3.1
2.5
1.04
1.46
e6/l
0.75
131
1078
63
285
2.27
8.23
1.7
2.0
16.80
11.90
mg/l
0.76
57
260
49
203
2.46
7.80
1.6
1.5
—
—
—
0
0
39
146
2.72
7.61
1.5
1.5
—
—
—
0
0
50
212
2.41
7.58
1.6
1.5
—
—
—
0
0
41
158
2.64
7.57
1.1
1.3
114.25
111.35
u/ml
—
8
33
45
183
2.51
7.46
1.1
1.2
—
—
—
0
0
1261
11772
1.58
7.43
5.7
4.7
1.36
1.47
mmol/l
20.82
1202
10765
39
148
2.68
7.42
1.1
1.1
117.88
115.76
%
0.18
34
136
13
12
10.92
7.30
1.6
1.8
—
—
—
0
0
1020
9162
1.39
7.24
4.3
4.0
15.08
14.90
pmol/l
1.30
923
8274
484
3887
1.37
7.00
2.0
2.1
136.97
226.54
u/l
3.08
450
3631
1265
11873
1.55
6.65
5.8
4.7
4.24
4.62
mmol/l
34.58
1210
10931
29
100
2.94
6.60
2.2
2.2
—
—
—
0
0
45
196
2.34
6.47
1.6
1.5
—
—
—
0
0
1285
12124
1.57
6.36
6.4
5.3
2.44
2.71
mmol/l
23.64
1231
11104
41
173
2.41
6.33
1.1
1.2
265.84
257.82
u/ml
0.07
31
97
11
10
11.07
6.30
1.5
1.3
—
—
—
0
0
164
1096
1.56
6.24
2.9
3.0
5.78
5.82
kpa
0.22
159
1060
169
1140
1.55
6.17
3.8
3.1
—
—
—
0
0
10
8
12.58
6.08
1.5
1.1
—
—
—
0
0
147
965
1.58
6.05
3.1
2.3
59.58
65.53
ml/min/173m2
1.40
86
375
75
410
1.87
5.97
1.7
1.8
0.89
1.76
ug/l
1.32
68
360
162
1091
1.55
5.96
2.9
3.0
1.41
2.05
mmol/l
1.03
137
919
17
34
5.05
5.88
1.4
1.1
69.57
86.31
%
—
7
16
23
75
3.10
5.78
1.1
1.4
7.00
7.10
mmol/l
0.06
23
68
153
1030
1.54
5.64
1.9
1.8
435.13
362.65
nmol/l
3.29
141
924
35
146
2.43
5.57
1.2
1.2
—
—
—
0
0
16
33
4.89
5.43
1.5
1.2
69.29
88.12
%
—
7
16
15
29
5.22
5.39
1.1
1.3
—
—
—
0
0
26
95
2.77
5.38
1.3
1.6
143377.21
95439.37
e6/l
0.16
19
56
178
1254
1.48
5.29
7.5
6.6
4.99
5.08
kpa
0.64
173
1196
178
1254
1.48
5.29
7.5
6.6
13.26
11.55
kpa
1.93
171
1194
5
0
+∞
5.21
1.0
0.0
—
—
—
0
0
16
44
3.67
5.21
2.4
4.6
—
—
—
0
0
1352
12997
1.68
5.16
43.5
18.7
39.35
40.08
%
3.86
1265
11994
28
109
2.60
5.15
2.6
1.8
16.88
31.49
u/ml
0.67
23
98
1352
13003
1.67
5.07
43.6
18.7
450.47
248.44
e9/l
247.93
1332
12604
58
309
1.91
5.03
1.2
1.2
—
—
—
0
0
49
246
2.03
5.03
3.2
2.8
7.71
7.96
kpa
0.61
49
239
176
1250
1.46
5.02
7.5
6.6
0.68
1.27
mmol/l
0.95
139
983
1352
13007
1.67
5.02
43.5
18.7
8.08
6.70
e9/l
14.48
1329
12554
1352
13010
1.66
4.97
43.4
18.7
4.20
4.49
e12/l
41.27
1327
12554
34
148
2.33
4.96
1.7
1.4
—
—
—
0
0
34
148
2.33
4.96
1.7
1.4
—
—
—
0
0
1352
13013
1.66
4.93
43.7
18.8
130.73
135.66
g/l
25.56
1341
12769
25
94
2.69
4.92
1.4
1.6
—
—
—
0
0
37
171
2.19
4.71
1.6
1.2
—
—
—
0
0
85
521
1.67
4.65
3.0
3.1
23.72
24.21
mmol/l
0.65
85
507
16
48
3.36
4.61
1.1
1.3
8.44
9.42
u/l
0.26
16
43
426
3535
1.29
4.53
2.7
2.3
55.36
59.72
u/l
1.17
382
3232
516
4395
1.27
4.44
4.0
3.9
—
—
—
0
0
26
106
2.48
4.39
1.3
1.6
1210.30
1712.00
e6/l
0.59
20
78
1192
11250
1.35
4.35
6.2
6.2
38.00
40.40
mmol/mol
17.75
1122
10374
15
46
3.28
4.19
1.5
2.4
1010.87
1013.57
u/ml
0.00
15
46
14
41
3.44
4.19
1.6
1.1
—
—
—
0
0
14
41
3.44
4.19
1.6
1.1
—
—
—
0
0
567
4913
1.25
4.15
2.3
2.3
80.62
79.03
nmol/l
0.63
494
4297
43
222
1.97
4.14
2.4
2.4
16.36
16.48
%
0.05
21
117
14
42
3.36
4.05
1.1
1.1
—
—
—
0
0
7
7
10.04
4.01
2.3
1.4
2.29
2.43
%
—
7
7
9
14
6.46
3.98
1.6
3.4
—
—
—
0
0
58
335
1.76
3.96
2.3
3.0
—
—
—
0
0
59
343
1.75
3.94
1.3
1.6
1.12
1.16
g/l
0.49
54
327
75
466
1.64
3.93
1.7
1.9
38.04
39.18
u/l
0.18
64
402
22
88
2.52
3.89
1.4
1.3
—
—
—
0
0
58
337
1.75
3.89
1.3
1.6
0.23
0.23
g/l
0.04
52
325
540
4680
1.25
3.88
4.1
3.8
35.84
74.09
ng/l
1.34
415
3326
366
3034
1.28
3.84
4.2
4.1
0.00
0.00
estimate
0.69
168
947
1235
11778
1.35
3.73
5.1
4.8
5.89
6.00
mmol/l
2.51
1131
10659
105
720
1.49
3.61
3.1
3.4
5.17
5.18
kpa
0.05
99
682
49
278
1.79
3.58
1.9
1.6
—
—
—
0
0
100
681
1.50
3.56
2.9
3.4
2.24
1.83
mmol/l
0.51
72
497
6
6
10.03
3.50
1.0
1.0
—
—
—
0
0
72
458
1.60
3.47
2.3
1.7
—
—
—
0
0
23
100
2.32
3.44
1.4
1.3
—
—
—
0
0
43
239
1.82
3.37
1.5
1.4
—
—
—
0
0
43
239
1.82
3.37
1.5
1.4
—
—
—
0
0
56
337
1.69
3.35
1.1
1.1
—
—
—
0
0
67
423
1.61
3.34
2.1
1.6
—
—
—
0
0
56
340
1.67
3.25
1.1
1.1
—
—
—
0
0
21
91
2.33
3.18
1.2
1.2
—
—
—
0
0
21
91
2.33
3.18
1.2
1.2
—
—
—
0
0
53
320
1.68
3.15
1.6
1.7
—
—
—
0
0
6
8
7.53
3.05
1.7
1.3
—
—
—
0
0
21
93
2.28
3.04
1.2
1.2
—
—
—
0
0
21
93
2.28
3.04
1.2
1.2
—
—
—
0
0
21
93
2.28
3.04
1.2
1.2
—
—
—
0
0
293
2428
1.26
3.03
1.3
1.2
2.23
1.67
u/ml
0.32
40
645
386
3309
1.23
2.93
1.7
1.7
1.40
1.36
mmol/l
0.33
337
2753
11
33
3.35
2.81
1.1
2.5
—
6647.80
—
0
5
25
124
2.03
2.77
1.4
1.5
—
—
—
0
0
18
78
2.32
2.75
1.6
1.2
—
—
—
0
0
18
78
2.32
2.75
1.6
1.2
—
—
—
0
0
18
78
2.32
2.75
1.6
1.2
—
—
—
0
0
25
126
2.00
2.66
1.4
1.4
—
—
—
0
0
16
67
2.40
2.63
1.3
2.0
—
—
—
0
0
16
67
2.40
2.63
1.4
1.5
—
—
—
0
0
30
162
1.87
2.63
1.6
1.4
—
—
—
0
0
24
120
2.02
2.61
1.5
1.3
—
—
—
0
0
24
123
1.97
2.46
4.4
4.1
—
—
—
0
0
12
45
2.68
2.45
1.8
2.5
30.71
47.42
%
—
7
24
708
6502
1.18
2.42
2.9
2.7
—
—
—
0
0
8
22
3.65
2.36
1.1
1.0
—
—
—
0
0
10
33
3.04
2.36
1.0
1.4
—
—
—
0
0
26
140
1.87
2.33
1.7
1.3
—
—
—
0
0
9
28
3.23
2.31
1.7
1.1
—
—
—
0
0
9
28
3.23
2.31
1.7
1.1
—
—
—
0
0
9
28
3.23
2.31
1.7
1.1
—
—
—
0
0
144
1131
1.30
2.30
3.2
3.1
168.78
212.06
ng/l
1.40
137
1041
46
297
1.57
2.18
1.1
1.1
0.89
8.52
u/ml
—
7
29
43
275
1.58
2.13
1.2
1.3
—
—
—
0
0
17
81
2.11
2.13
1.4
1.5
1.06
0.97
g/l
0.36
17
81
26
145
1.81
2.11
1.0
1.4
281.79
328.81
pmol/l
0.31
19
126
155
1244
1.28
2.11
2.1
2.2
198.22
139.16
ug/g
0.55
125
971
121
943
1.31
2.06
3.2
3.6
90.69
88.63
ng/l
0.09
105
811
17
83
2.06
2.01
1.1
1.1
—
—
—
0
0
8
28
2.87
1.86
1.0
1.3
—
—
—
0
0
18
93
1.95
1.85
3.2
2.1
—
—
—
0
0
20
108
1.86
1.82
1.7
1.5
—
—
—
0
0
20
108
1.86
1.82
1.7
1.5
—
—
—
0
0
104
810
1.31
1.81
2.5
2.4
23.55
22.62
au/ml
0.03
12
51
94
722
1.32
1.80
1.3
1.3
49.14
53.05
au/ml
—
7
40
86
653
1.34
1.79
1.6
1.5
—
—
—
0
0
11
48
2.30
1.70
1.4
1.2
—
—
—
0
0
22
126
1.76
1.68
1.2
1.2
—
—
—
0
0
12
55
2.19
1.67
1.4
1.4
—
—
—
0
0
22
127
1.74
1.64
1.2
1.2
—
—
—
0
0
47
329
1.44
1.60
1.1
1.2
3.80
8.02
u/ml
—
5
58
28
176
1.60
1.55
1.3
1.1
—
—
—
0
0
21
122
1.73
1.55
1.3
1.2
—
—
—
0
0
5
15
3.34
1.52
1.8
1.5
—
—
—
0
0
21
123
1.72
1.51
1.2
1.2
—
—
—
0
0
94
745
1.28
1.47
2.2
2.7
128.73
130.88
g/l
0.42
89
720
21
124
1.70
1.47
1.3
1.2
—
—
—
0
0
10
45
2.23
1.46
1.5
1.4
—
—
—
0
0
10
45
2.23
1.46
1.5
1.4
—
—
—
0
0
13
66
1.98
1.43
1.2
1.1
—
—
—
0
0
21
126
1.68
1.40
1.2
1.2
—
—
—
0
0
33
224
1.48
1.34
1.3
1.3
—
—
—
0
0
64
825
0.77
1.30
1.7
1.8
—
—
—
0
0
52
387
1.36
1.29
1.3
1.9
—
—
—
0
0
5
18
2.78
1.28
1.0
1.2
—
—
—
0
0
5
18
2.78
1.28
1.0
1.1
—
—
—
0
0
5
18
2.78
1.28
1.6
1.2
—
—
—
0
0
10
49
2.05
1.22
1.4
1.3
—
—
—
0
0
232
2056
1.15
1.19
1.2
1.3
26.38
39.04
iu/ml
1.08
67
670
11
57
1.94
1.17
1.3
1.1
46.47
21.46
u/l
0.94
11
49
12
65
1.85
1.13
1.3
1.6
—
—
—
0
0
361
3931
0.89
1.13
3.0
3.2
988.67
192.59
mg/l
1.23
211
2442
89
728
1.24
1.12
1.3
1.2
124.97
125.10
iu/ml
0.00
26
292
7
31
2.26
1.10
2.1
1.6
—
—
—
0
0
11
59
1.87
1.07
1.2
1.2
—
—
—
0
0
16
97
1.66
1.07
1.1
1.2
—
—
—
0
0
23
154
1.50
1.04
1.3
1.3
—
—
—
0
0
5
22
2.28
1.03
1.4
1.1
—
—
—
0
0
7
34
2.06
1.03
1.1
1.8
—
2024630.00
—
0
5
389
3597
1.11
1.02
4.3
3.8
3.88
1.94
ug/l
0.66
331
3225
10
53
1.89
1.01
1.2
1.2
—
—
—
0
0
10
53
1.89
1.01
1.2
1.2
—
—
—
0
0
184
1625
1.15
1.01
1.5
1.4
—
—
—
0
0
7
35
2.00
1.00
1.7
1.2
88.29
115.30
%
—
7
30
9
49
1.84
0.98
3.6
1.4
—
—
—
0
0
20
133
1.51
0.94
1.3
1.0
3.09
2.33
u/ml
—
8
55
385
4138
0.90
0.94
3.4
3.8
9.26
7.70
mg/mmol
0.29
223
2550
39
295
1.33
0.93
1.5
1.4
276.88
301.61
ug/g
0.35
25
170
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
10
55
1.82
0.92
1.2
1.1
—
—
—
0
0
20
135
1.49
0.89
1.7
6.3
8.08
7.55
mmol/l
0.26
15
113
63
512
1.24
0.88
1.2
1.3
—
—
—
0
0
6
30
2.00
0.87
1.3
1.5
—
—
—
0
0
28
204
1.38
0.85
1.5
1.6
—
—
—
0
0
10
58
1.73
0.79
2.3
2.4
—
—
—
0
0
6
33
1.82
0.79
1.2
1.1
—
—
—
0
0
5
96
0.52
0.78
1.2
1.5
—
—
—
0
0
54
439
1.24
0.78
2.7
3.7
24.52
24.72
mmol/l
0.19
48
402
22
303
0.72
0.77
1.7
1.6
6583.73
12548.82
e6/l
1.30
15
222
7
38
1.85
0.73
1.3
1.3
—
—
—
0
0
7
38
1.85
0.73
1.3
1.3
—
—
—
0
0
9
57
1.58
0.71
1.3
1.9
—
—
—
0
0
9
57
1.58
0.71
1.0
1.0
—
—
—
0
0
16
110
1.46
0.68
1.4
1.6
—
—
—
0
0
71
604
1.18
0.68
2.3
2.3
12.48
14.48
nmol/l
1.25
60
534
21
153
1.38
0.67
1.1
1.1
—
—
—
0
0
17
119
1.43
0.67
1.1
1.1
—
—
—
0
0
14
201
0.69
0.64
1.3
1.5
—
—
—
0
0
384
4057
0.93
0.63
2.9
3.1
6.88
7.24
mmol/l
0.96
317
3413
40
325
1.24
0.61
1.5
1.6
1.68
0.09
iu/ml
—
6
68
26
333
0.78
0.59
2.8
2.2
21.83
95.19
ug/min
1.98
12
207
148
1626
0.90
0.58
7.2
6.7
—
—
—
0
0
13
91
1.43
0.53
1.5
1.2
—
—
—
0
0
10
66
1.52
0.52
1.7
2.0
19.40
172.57
ug/min
—
5
14
215
2007
1.08
0.50
1.2
1.3
15.04
13.75
u/ml
0.08
65
763
129
1184
1.10
0.44
2.6
2.5
4.96
7.50
ug/l
1.73
113
1035
7
51
1.37
0.44
1.0
1.2
—
—
—
0
0
8
56
1.43
0.42
1.1
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
33
278
1.19
0.40
1.6
1.3
—
—
—
0
0
5
35
1.43
0.39
1.0
1.1
—
—
—
0
0
33
279
1.19
0.39
3.6
3.3
0.82
0.78
nmol/l
0.29
28
211
21
170
1.24
0.37
1.2
1.9
810.86
2706.98
u/l
—
5
66
126
1172
1.08
0.35
1.4
1.8
1.44
1.50
%
0.62
106
1001
149
1587
0.93
0.34
5.3
4.8
31.48
33.07
%
1.07
113
1050
10
133
0.75
0.33
1.4
1.5
—
—
—
0
0
60
541
1.11
0.32
1.0
1.0
—
—
—
0
0
29
335
0.86
0.29
2.1
1.6
—
—
—
0
0
7
56
1.25
0.29
2.0
2.5
43000.00
41667.86
ug/l
—
7
56
8
63
1.27
0.27
1.0
1.0
—
—
—
0
0
8
66
1.21
0.26
1.0
1.0
—
—
—
0
0
14
113
1.24
0.26
1.1
1.0
4.12
1.11
u/ml
—
7
56
12
96
1.25
0.24
1.8
1.4
—
—
—
0
0
30
266
1.13
0.22
1.6
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
17
145
1.17
0.20
1.1
1.1
0.10
1.80
u/ml
—
7
70
31
278
1.12
0.20
2.7
3.6
33.53
26.97
mg/l
0.38
20
174
6
48
1.25
0.20
1.2
1.1
87.00
253.02
iu/ml
—
6
48
14
164
0.85
0.18
1.2
1.5
—
—
—
0
0
278
2706
1.03
0.18
1.6
1.7
454.54
17671296.79
pmol/l
1.75
214
2224
31
282
1.10
0.16
1.4
1.1
—
—
—
0
0
5
70
0.71
0.16
4.0
1.7
17.00
18.64
nmol/l
—
5
57
12
101
1.19
0.16
4.9
2.2
14.31
13.18
%
2.43
12
101
257
2633
0.97
0.15
3.7
4.2
1.02
1.02
kg/l
0.39
32
395
207
2014
1.03
0.15
2.7
2.7
0.71
0.72
ug/l
0.09
141
1342
79
753
1.05
0.14
1.6
1.8
—
—
—
0
0
10
84
1.19
0.14
1.4
1.2
9.82
9.14
mmol/l
—
10
78
31
286
1.09
0.13
1.2
1.9
1.83
5.04
iu/l
—
9
98
36
336
1.07
0.12
1.7
1.7
—
—
—
0
0
32
344
0.93
0.12
1.4
1.3
—
—
—
0
0
70
673
1.04
0.10
1.6
1.8
—
—
—
0
0
22
238
0.92
0.09
1.1
1.2
194.22
232.30
miu/ml
—
9
105
11
124
0.89
0.09
1.5
1.6
—
—
—
0
0
12
107
1.12
0.08
1.1
1.1
—
—
—
0
0
5
62
0.81
0.08
1.4
6.5
—
70.11
—
0
18
14
154
0.91
0.08
1.4
1.5
61.33
62.05
%
—
6
98
7
65
1.08
0.08
1.6
1.4
1.39
1.57
g/l
—
7
65
6
70
0.86
0.07
1.0
1.2
—
—
—
0
0
295
2914
1.02
0.07
3.8
3.7
23.41
23.98
%
0.23
149
1362
10
89
1.12
0.07
1.2
1.8
5.22
5.55
umol/l
—
5
52
36
344
1.05
0.06
1.6
1.4
—
—
—
0
0
9
104
0.86
0.06
1.1
1.1
—
4.83
—
0
6
160
1626
0.98
0.06
1.4
1.4
—
—
—
0
0
12
110
1.09
0.05
1.4
1.4
21.60
29.00
%
—
5
69
11
118
0.93
0.02
1.3
1.1
—
—
—
0
0
11
117
0.94
0.01
1.5
1.5
—
—
—
0
0
11
117
0.94
0.01
1.5
1.5
—
—
—
0
0
11
117
0.94
0.01
1.5
1.5
—
—
—
0
0
11
117
0.94
0.01
1.5
1.5
—
—
—
0
0
70
693
1.01
0.01
1.2
1.2
201.16
192.52
u/ml
0.04
65
634
11
112
0.98
0.00
1.7
2.2
3.20
2.47
u/field
—
5
43
31
308
1.01
0.00
1.4
1.5
—
—
—
0
0
16
155
1.03
0.00
1.0
1.1
—
16.76
—
0
8
13
125
1.04
0.00
1.8
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
7.52
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
65
0.92
-0.00
1.8
1.4
183.77
175.34
pmol/l
—
6
65
6
67
0.90
-0.00
1.7
1.8
0.33
2.99
u/field
—
6
50
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
91
0.99
-0.00
1.1
1.0
—
—
—
0
0
9
92
0.98
-0.00
1.1
1.1
—
—
—
0
0
6
69
0.87
-0.00
1.0
1.1
—
—
—
0
0
6
67
0.90
-0.00
1.3
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
1.12
—
0
5
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
78
0.90
-0.00
1.0
1.6
116.00
85.69
umol/l
—
7
78
Mortality – FinRegistry
↥Association
Association between endpoint THROMBOCYTAEMIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| THROMBOCYTAEMIA | 1.67 [1.48, 1.89] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.11 |
During the follow-up period (1.1.1998 — 31.12.2019), 986 out of 3701 females with THROMBOCYTAEMIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| THROMBOCYTAEMIA | 1.754 [1.51, 2.03] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 774 out of 2419 males with THROMBOCYTAEMIA died.
Mortality risk
Mortality risk for people of age
years, who have THROMBOCYTAEMIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.146% | 0.269% |
| 5 | 0.888% | 1.789% |
| 10 | 2.432% | 4.669% |
| 15 | 4.498% | 8.667% |
| 20 | 7.643% | 14.191% |
Relationships between endpoints
↥Index endpoint: THROMBOCYTAEMIA – Essential (haemorrhagic) thrombocythaemia
GWS hits: 14
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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