MS-disease / Multiple Sclerosis

G6_MS

multiple sclerosis: A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 G35
Hospital discharge: ICD-9 340
Hospital discharge: ICD-8 34099
Cause of death: ICD-10 G35
Cause of death: ICD-9 340
Cause of death: ICD-8 34099
KELA reimbursements: KELA codes 109

1768

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1758

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Check minimum number of events None

1758

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Include endpoints None

1758

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G6_MS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G35-G37
Name in latin Sclerosis multiplex

Similar endpoints

List of similar endpoints to MS-disease / Multiple Sclerosis based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 1676 1274 402
Unadjusted prevalence (%) 0.54 0.73 0.30
Mean age at first event (years) 39.56 38.58 42.65

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.01 0.76 [0.31, 1.83] 5.3e-1 69
15 years 0.00 0.65 [0.28, 1.52] 3.2e-1 32
5 years 0.00 1.62 [0.74, 3.55] 2.3e-1 17
1 year - - - -

Correlations

Index endpoint: G6_MS – MS-disease / Multiple Sclerosis
GWS hits: 1

Survival analyses between endpoints

Plot

before MS-disease / Multiple Sclerosis
after MS-disease / Multiple Sclerosis

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Drugs most likely to be purchased after MS-disease / Multiple Sclerosis