Risteys · H7_INTERHETEROTRO

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H50.30, H50.31, H50.39 Hospital discharge: ICD-9 — 3782 Cause of death: ICD-10 — H50.30, H50.31, H50.39 Cause of death: ICD-9 — 3782 2 out of 7 registries used, show all original rules.	2445
4. Check minimum number of events None	2445
5. Include endpoints None	2445
6. Filter based on genotype QC (FinnGen only)	2445

	All	Female	Male
Number of individuals
Whole population	40828	21955	18837
Only index persons	29323	15895	13428
Unadjusted period prevalence (%)
Whole population	0.58	0.63	0.53
Only index persons	0.55	0.58	0.51
Median age at first event (years)
Whole population	5.28	5.40	5.07
Only index persons	6.80	7.08	6.45

	All	Female	Male
Number of individuals	2445	1619	826
Unadjusted period prevalence (%)	0.49	0.55	0.36
Median age at first event (years)	22.05	19.37	27.30

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
2174: Matched controls
21731

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H50.30

ICD-10 Finland

Intermittent esotropy

4067.8

323.0

620

H50.1

ICD-10 Finland

Divergent concomitant strabismus

3959.2

323.0

347

H50.31

ICD-10 Finland

Intermittent exotropia

15080.1

323.0

1314

H50.52

ICD-10 Finland

Exophoria

884.7

323.0

369

CEC10

NOMESCO Finland

Recession and resection of extraocular muscle

+∞

323.0

457

3782B

ICD-9 Finland

Strabismus and other disorders of binocular eye movements, Intermittent heterotropia[STRABISMUS DIVERGENS INTERMITTENS]

+∞

307.7

288

H50.0

ICD-10 Finland

Convergent concomitant strabismus

2846.7

278.0

263

CEC00

NOMESCO Finland

Recession of extraocular muscle

+∞

254.2

239

3503

FHL

Single muscle retroposition

+∞

250.9

236

H53.2

ICD-10 Finland

Diplopia

18.1

138.4

221

135

3507

FHL

Retroposition and resection

+∞

124.1

118

H52.0

ICD-10 Finland

Hypermetropia

35.6

122.2

159

37301

ICD-8 Finland

Strabismus, Concomitans divergens

+∞

114.6

109

H50.2

ICD-10 Finland

Vertical strabismus

543.1

105.6

104

H53.0

ICD-10 Finland

Amblyopia ex anopsia

27.1

95.6

133

CEC30

NOMESCO Finland

Resection of extraocular muscle

+∞

93.4

H50.51

ICD-10 Finland

Esophoria

128.1

91.7

Z01.0

ICD-10 Finland

Examination of eyes and vision

3.2

80.0

490

1798

XCW99

NOMESCO Finland

Other investigative procedure of eye

4.4

79.9

316

803

H52.2

ICD-10 Finland

Astigmatism

27.2

75.0

104

H50.9

ICD-10 Finland

Strabismus, unspecified

54.5

66.4

H52.1

ICD-10 Finland

Myopia

9.5

59.5

126

140

H52.3

ICD-10 Finland

Anisometropia and aniseikonia

82.4

57.2

H50.3

ICD-10 Finland

Intermittent heterotropia

+∞

55.4

37303

ICD-8 Finland

Strabismus, Heterophoria (exophoria, esophroria, hypophoria)

+∞

49.1

3505

FHL

Single muscle resection

+∞

49.1

3782A

ICD-9 Finland

Strabismus and other disorders of binocular eye movements, Intermittent heterotropia[STRABISMUS CONVERGENS INTERMITTENS]

+∞

46.0

37300

ICD-8 Finland

Strabismus, Concomitans convergens

+∞

44.9

R5110

NOMESCO Finland

Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it

3.2

44.5

254

858

3781B

ICD-9 Finland

Strabismus and other disorders of binocular eye movements, Divergent concomitant strabismus[STRABISMUS DIVERGENS ALTERNANS]

+∞

43.9

H51.1

ICD-10 Finland

Convergence insufficiency and excess

+∞

42.8

H50.8

ICD-10 Finland

Other specified strabismus

+∞

40.7

3781A

ICD-9 Finland

Strabismus and other disorders of binocular eye movements, Divergent concomitant strabismus[STRABISMUS CONCOMITANS DIVERGENS]

+∞

38.6

H50.39

ICD-10 Finland

Intermittent heterotropia

198.3

37.9

WX140

NOMESCO Finland

Parabulbar anesthesy

5.7

35.2

105

193

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

2.9

34.1

227

847

CEC60

NOMESCO Finland

Transposition of extraocular muscle with adjustable suture

+∞

33.4

S01CA01

ATC

dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)

2.0

32.7

537

3115

CEW99

NOMESCO Finland

Other operation on extraocular muscle

+∞

32.4

F79.0

ICD-10 Finland

Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour

12.1

31.7

N03AG01

ATC

valproic acid; systemic, rectal

3.1

30.6

179

611

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

2.7

30.5

222

873

R62.0

ICD-10 Finland

Delayed milestone

5.7

30.5

164

3504

FHL

Retroposition of two muscles

295.5

28.8

XCK00

NOMESCO Finland

Perimetry

3.6

28.1

132

382

H49.2

ICD-10 Finland

Sixth [abducent] nerve palsy

146.8

27.7

F83

ICD-10 Finland

Mixed specific developmental disorders

5.4

27.3

161

F95

ICPC

Strabismus

263.4

25.7

AA1AD

NOMESCO Finland

CT of head and brain

2.0

25.1

352

1896

3784B

ICD-9 Finland

Strabismus and other disorders of binocular eye movements, Heterophoria[EXOPHORIA]

+∞

25.0

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

2.7

24.9

185

734

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

1.7

24.6

614

4034

N05AH04

ATC

quetiapine; oral

1.9

24.3

396

2257

N03AX11

ATC

topiramate; oral

4.3

24.2

217

F70.0

ICD-10 Finland

Mild mental retardation, With the statement of no, or minimal, impairment of behaviour

9.3

24.0

XA800

NOMESCO Finland

Neuropsychological investigation

3.0

23.4

141

491

CEC50

NOMESCO Finland

Advancement of extraocular muscle

+∞

21.9

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

2.5

21.6

183

780

WX408

NOMESCO Finland

General anesthesy, balanced

1.7

21.6

554

3648

ZXA10

NOMESCO Finland

Bilateral

1.9

21.5

348

1971

TCG00

NOMESCO Finland

Protection of cornea and sclera with soft lens

60.6

20.9

3780B

ICD-9 Finland

Strabismus and other disorders of binocular eye movements, Convergent concomitant strabismus[STRABISMUS CONVERGENS ALTERNANS]

+∞

20.9

H53.1

ICD-10 Finland

Subjective visual disturbances

2.9

20.8

129

457

H49.1

ICD-10 Finland

Fourth [trochlear] nerve palsy

211.8

20.6

RL140

NOMESCO Finland

9.9

20.1

ZXA00

NOMESCO Finland

Right side

1.8

19.7

414

2554

G40.9

ICD-10 Finland

Epilepsy, unspecified

3.6

19.3

261

G80.2

ICD-10 Finland

Spastic hemiplegic cerebral palsy

31.6

19.3

Z3229

NOMESCO Finland

Other healthcare associate professional

2.3

18.8

190

885

ZXA05

NOMESCO Finland

Left side

1.8

18.4

380

2329

P85

ICPC

Mental retardation

11.1

18.2

N05AH03

ATC

olanzapine; systemic

2.4

17.9

157

682

Z01.1

ICD-10 Finland

Examination of ears and hearing

1.9

17.6

285

1607

ZXE10

NOMESCO Finland

More than one and less than three hours

1.6

17.6

636

4538

G80.1

ICD-10 Finland

Spastic diplegic cerebral palsy

18.8

17.3

111

Kela drug reimbursment

Epilepsy and comparable convulsive disorders

2.6

17.3

127

502

F82

ICD-10 Finland

Specific developmental disorder of motor function

5.0

17.2

112

N05AX08

ATC

risperidone; systemic

2.3

17.1

163

738

H55

ICD-10 Finland

Nystagmus and other irregular eye movements

12.1

16.8

N06AX11

ATC

mirtazapine; oral

1.6

16.8

544

3772

Z96.1

ICD-10 Finland

Presence of intraocular lens

2.4

16.7

141

600

H50.4

ICD-10 Finland

Other and unspecified heterotropia

+∞

16.7

CEC20

NOMESCO Finland

Recession and advancement of extraocular muscle

+∞

16.7

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

1.6

16.5

488

3303

112

Kela drug reimbursment

Severe psychotic and other severe mental disorders

2.2

16.5

174

828

N05BA09

ATC

clobazam; oral

5.8

16.3

H53.3

ICD-10 Finland

Other disorders of binocular vision

15.4

16.2

TPH04

NOMESCO Finland

Cathetrisation of vein

1.7

16.1

344

2123

Z2445

NOMESCO Finland

Psychologist

2.2

16.0

164

769

Z50.9

ICD-10 Finland

Care involving use of rehabilitation procedure, unspecified

3.3

15.6

245

H50.50

ICD-10 Finland

Alternating hyperphoria

+∞

15.6

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

1.8

15.4

298

1782

182

Kela drug reimbursment

Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide

3.7

15.4

190

N03AX09

ATC

lamotrigine; oral

2.4

15.2

135

591

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

2.3

14.9

135

596

F79.9

ICD-10 Finland

Unspecified mental retardation, without mention of impairment of behaviour

21.2

14.6

N03AX12

ATC

gabapentin; oral

1.9

14.6

230

1283

H50

ICD-10 Finland

Other strabismus

150.9

14.5

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

2.0

14.4

179

912

AA1DG

NOMESCO Finland

Very extensive MRI examination of brain with high intensity magnet

3.1

14.2

258

N03AX16

ATC

pregabalin; oral

1.7

14.2

343

2188

G47.3

ICD-10 Finland

Sleep apnoea

1.7

13.8

285

1736

GD1AA

NOMESCO Finland

Thorax X-ray examination

1.5

13.8

638

4759

Z3231

NOMESCO Finland

Registered nurse

1.5

13.8

556

4028

N03AX14

ATC

levetiracetam; systemic

3.2

13.6

227

SPAT1229

SPAT

Assessment of need for aid

2.5

13.4

108

450

ZXD10

NOMESCO Finland

Scheduled procedure

1.5

13.2

676

5141

N06AX16

ATC

venlafaxine; oral

1.7

13.2

274

1673

H52.5

ICD-10 Finland

Disorders of accommodation

40.3

13.1

N05AH02

ATC

clozapine; systemic

3.5

13.1

179

SPAT1240

SPAT

Therapeutic discussion

1.7

13.0

298

1871

R1230

NOMESCO Finland

Neuropsychological evaluation of need and possibilities to rehabilitation

3.6

12.7

163

SPAT1216

SPAT

Assessment of functional ability

1.8

12.6

217

1245

N03AF02

ATC

oxcarbazepine; oral

2.8

12.5

281

F71.0

ICD-10 Finland

Moderate mental retardation, with the statement of no, or minimal, impairment of behaviour

17.4

12.5

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

2.1

12.5

139

678

R42

ICD-10 Finland

Dizziness and giddiness

1.6

12.4

311

1999

602

Kela drug reimbursment

Children's severe malnutrition

4.0

12.3

126

CK2S4

NOMESCO Finland

Plain photography of ocular fundus

2.5

12.3

394

WX100

NOMESCO Finland

Conjunctival surface anesthesia

2.2

12.3

123

571

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

1.8

12.2

222

1299

R1260

NOMESCO Finland

Evaluation of communicative skills

4.6

12.2

SPAT1310

SPAT

Counselling related to known health issue

1.4

12.2

666

5116

ZXE20

NOMESCO Finland

More than three and less than five hours

1.8

12.1

223

1312

G80.9

ICD-10 Finland

Cerebral palsy, unspecified

26.8

12.0

R51.80

ICD-10 Finland

Headache

1.6

12.0

338

2239

R06.5

ICD-10 Finland

Mouth breathing

2.0

12.0

150

766

N03AE01

ATC

clonazepam; systemic

2.5

11.9

401

SPAT1263

SPAT

Sampling

1.4

11.9

856

6906

Z01.8

ICD-10 Finland

Other specified special examinations

1.6

11.8

363

2462

WYA30

NOMESCO Finland

Preparations for expected poor cooperation

1.9

11.8

188

1052

F32.9

ICD-10 Finland

Depressive episode, unspecified

1.6

11.7

298

1923

L28

ICPC

Limited function/disability (L)

1.8

11.7

202

1160

183

Kela drug reimbursment

Lamotrigin and topiramate

4.2

11.7

103

CJE20

NOMESCO Finland

Phakoemulsification with implantation of artificial lens in posterior chamber

1.7

11.7

263

1640

N06AB04

ATC

citalopram; systemic

1.6

11.6

334

2224

N05BA01

ATC

diazepam; systemic, rectal

1.8

11.6

213

1249

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

2.0

11.5

139

701

N04AA02

ATC

biperiden; systemic

3.8

11.5

129

Z03.3

ICD-10 Finland

Observation for suspected nervous system disorder

2.2

11.5

118

556

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

1.7

11.5

231

1395

504

Kela drug reimbursment

Conditions requiring daily forced enteral nutrition

4.1

11.5

110

RT150

NOMESCO Finland

5.5

11.5

3780A

ICD-9 Finland

Strabismus and other disorders of binocular eye movements, Convergent concomitant strabismus[STRABISMUS CONCOMITANS CONVERGENS]

+∞

11.5

H49.0

ICD-10 Finland

Third [oculomotor] nerve palsy

+∞

11.5

N02BE01

ATC

paracetamol; systemic, rectal

1.4

11.4

1529

13659

M03BX01

ATC

baclofen; systemic

4.4

11.4

R50.9

ICD-10 Finland

Fever, unspecified

1.6

11.4

296

1923

C07AA05

ATC

propranolol; systemic

1.6

11.4

368

2523

M41.4

ICD-10 Finland

Neuromuscular scoliosis

15.1

11.3

N02AX02

ATC

tramadol; systemic, rectal

1.4

11.3

572

4316

N05AB03

ATC

perphenazine; systemic, rectal

2.8

11.2

252

SPAT1301

SPAT

No procedures

1.4

11.2

593

4507

G40.20

ICD-10 Finland

Complex partial seizures with only alteration of consciousness

5.5

11.2

ZXE13

NOMESCO Finland

Procedure duration 90 to 119 minutes

2.1

11.2

125

612

TAB00

NOMESCO Finland

Lumbar puncture

2.3

11.1

430

Z71.3

ICD-10 Finland

Dietary counselling and surveillance

2.2

11.1

112

521

A06AD11

ATC

lactulose; oral

1.8

11.1

186

1060

G91.1

ICD-10 Finland

Obstructive hydrocephalus

9.2

11.0

NA7EA

NOMESCO Finland

Scoliosis X-ray examination

3.7

11.0

125

R5140

NOMESCO Finland

Monitoring the use of the aid

2.0

10.9

139

717

Z01.5

ICD-10 Finland

Diagnostic skin and sensitization tests

1.8

10.8

200

1176

H04.10

ICD-10 Finland

Dry eye syndrome

2.0

10.8

144

756

CA1CG

NOMESCO Finland

Eye and orbita extensive MRI examination with high intensity magnet

7.2

10.7

XKD00

NOMESCO Finland

Uroflowmetry

1.8

10.7

174

980

UKC02

NOMESCO Finland

Cystoscopy

1.8

10.7

188

1087

CE2W4

NOMESCO Finland

Eye movement mapping

21.5

10.7

N06AX21

ATC

duloxetine; oral

1.8

10.7

179

1021

RT190

NOMESCO Finland

12.9

10.6

AA1BM

NOMESCO Finland

MRI examination of brain with 3 Tesla magnet

4.5

10.5

N04BA02

ATC

levodopa and decarboxylase inhibitor; oral

3.5

10.5

135

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

1.5

10.5

395

2798

R56.8

ICD-10 Finland

Other and unspecified convulsions

2.1

10.4

122

609

G80.3

ICD-10 Finland

Dyskinetic cerebral palsy

110.4

10.4

3783A

ICD-9 Finland

Strabismus and other disorders of binocular eye movements, Other and unspecified heterotropia

+∞

10.4

R1410

NOMESCO Finland

Drawing up a rehabilitation plan

7.7

10.4

N05AX12

ATC

aripiprazole; systemic

2.1

10.4

115

562

R2130

NOMESCO Finland

Counselling and guidance which enhance independent living

1.8

10.3

168

947

Z2446

NOMESCO Finland

Social worker

1.7

10.3

195

1158

KH1AE

NOMESCO Finland

Urinary tract ultrasound examination

2.2

10.2

102

475

RT490

NOMESCO Finland

9.6

10.2

G81.1

ICD-10 Finland

Spastic hemiplegia

23.5

10.2

WX404

NOMESCO Finland

Intravenous generell anesthesy

1.5

10.2

393

2797

H03AA01

ATC

levothyroxine sodium; systemic

1.5

10.2

348

2413

N03AF01

ATC

carbamazepine; oral, rectal

2.6

10.2

298

SPAT1312

SPAT

General health counselling

1.4

10.2

742

5957

M02AA10

ATC

ketoprofen; topical

1.7

10.1

210

1277

Z46.8

ICD-10 Finland

Fitting and adjustment of other specified devices

3.5

10.1

129

F32.2

ICD-10 Finland

Severe depressive episode without psychotic symptoms

1.8

10.0

159

891

RT274

NOMESCO Finland

14.6

10.0

N04BC05

ATC

pramipexole; oral

2.2

10.0

100

467

H50.59

ICD-10 Finland

Heterophor UNS

40.2

10.0

H25.0

ICD-10 Finland

Senile incipient cataract

2.7

9.9

238

N05AA02

ATC

levomepromazine; systemic

2.6

9.9

291

N05BA06

ATC

lorazepam; systemic, sublingual

2.5

9.8

320

N05CD08

ATC

midazolam; nasal, systemic

3.0

9.8

192

KC1EE

NOMESCO Finland

Ultrasound measurement of residual urine

1.9

9.8

147

807

Z87.6

ICD-10 Finland

Personal history of certain conditions arising in the perinatal period

3.1

9.7

166

F71.1

ICD-10 Finland

Moderate mental retardation, significant impairment of behaviour requiring attention or treatment

55.2

9.6

G44.2

ICD-10 Finland

Tension-type headache

1.6

9.5

238

1528

M79.6

ICD-10 Finland

Pain in limb

1.4

9.5

575

4456

SPAT1153

SPAT

Removal of sutures

1.4

9.5

450

3335

AAF20

NOMESCO Finland

Revision of shunt of ventricle of brain

15.1

9.5

XKD06

NOMESCO Finland

Physiologic investigation of micturition

3.1

9.5

158

H02.4

ICD-10 Finland

Ptosis of eyelid

3.5

9.4

126

WX110

NOMESCO Finland

Local anesthesy

1.3

9.4

1430

12794

H51.9

ICD-10 Finland

Disorder of binocular movement, unspecified

100.4

9.4

N05BA04

ATC

oxazepam; oral

1.5

9.4

399

2893

H51.8

ICD-10 Finland

Other specified disorders of binocular movement

+∞

9.4

N05CF01

ATC

zopiclone; oral

1.5

9.4

408

2977

N06AA09

ATC

amitriptyline; systemic

2.0

9.3

120

622

F70.1

ICD-10 Finland

Mild mental retardation, Significant impairment of behaviour requiring attention or treatment

8.1

9.3

G20

ICD-10 Finland

Parkinson disease

3.5

9.3

117

SPAT1033

SPAT

Irrigation or wax removal of outer auditory canal

1.6

9.3

232

1490

SPAT1220

SPAT

Assessment of need for rehabilitation and/or rehabilitation plan

2.0

9.2

121

631

SPAT1249

SPAT

Treatment-related counselling outside office

1.3

9.2

795

6530

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

1.5

9.1

322

2245

SPAT1256

SPAT

Intramuscular and subcutaneous injection

1.4

9.1

699

5634

SDA02

NOMESCO Finland

Parodonthologic therapy

1.4

9.0

625

4952

WX002

NOMESCO Finland

Sedation and analgesia

1.5

9.0

284

1931

ZXE00

NOMESCO Finland

One hour or less

1.3

9.0

736

5990

N10

ICD-10 Finland

Acute tubulo-interstitial nephritis

1.7

9.0

188

1149

CA1CM

NOMESCO Finland

Eye and orbita extensive MRI examination with 3 Tesla magnet

24.1

8.9

F72.0

ICD-10 Finland

Severe mental retardation, with the statement of no, or minimal, impairment of behaviour

24.1

8.9

EB1AA

NOMESCO Finland

Tooth X-ray examination

1.3

8.8

998

8515

SPAT1260

SPAT

Consultation of another employee

1.5

8.8

318

2230

H90.3

ICD-10 Finland

Sensorineural hearing loss, bilateral

1.8

8.8

161

947

G40.10

ICD-10 Finland

Simple partial seizures

4.5

8.6

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

1.8

8.6

145

826

ZXD20

NOMESCO Finland

Day surgery

1.6

8.6

211

1346

WX882

NOMESCO Finland

High dependency care

2.1

8.6

452

G40.12

ICD-10 Finland

Simple partial seizures with secondary generalization

4.0

8.5

K21.0

ICD-10 Finland

Gastro-oesophageal reflux disease with oesophagitis

1.9

8.5

130

720

RS142

NOMESCO Finland

9.0

8.5

H53.4

ICD-10 Finland

Visual field defects

3.7

8.5

N05AF03

ATC

chlorprothixene; systemic

2.7

8.5

200

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

1.5

8.4

277

1901

Z03.89

ICD-10 Finland

Observation for other suspected diseases and conditions

1.5

8.4

268

1826

H47.2

ICD-10 Finland

Optic atrophy

7.9

8.4

3508

FHL

Transposition or anteposition

+∞

8.3

CEC40

NOMESCO Finland

Resection and advancement of extraocular muscle

+∞

8.3

H50.5

ICD-10 Finland

Heterophoria

+∞

8.3

K02.1

ICD-10 Finland

Caries of dentine

1.3

8.3

1189

10449

WX402

NOMESCO Finland

General anaesthesia

1.5

8.3

311

2196

H54.7

ICD-10 Finland

Unspecified visual loss

6.2

8.3

N06AB06

ATC

sertraline; oral

1.6

8.3

222

1451

TPH20

NOMESCO Finland

Insertion of central venous catheter through subclavian or brachiocephalic vein

3.0

8.2

152

AA5HE

NOMESCO Finland

Brain ultrasound examination in a child

3.1

8.2

141

UDC00

NOMESCO Finland

Ear microscopy

1.8

8.2

138

788

K59.09

ICD-10 Finland

Constipation, unspecified

2.0

8.2

489

110

Kela drug reimbursment

Parkinson's disease and comparable movement disrorders

3.4

8.1

110

N28

ICPC

Limited function/disability (N)

4.8

8.1

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

1.5

8.0

260

1774

G40.29

ICD-10 Finland

Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures

3.2

8.0

127

G80.0

ICD-10 Finland

Spastic quadriplegic cerebral palsy

22.1

8.0

N05AD01

ATC

haloperidol; systemic

2.8

8.0

179

J18.9

ICD-10 Finland

Pneumonia, unspecified

1.5

8.0

301

2128

Z31.5

ICD-10 Finland

Genetic counselling

1.9

7.9

117

640

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

1.4

7.9

371

2735

P22.0

ICD-10 Finland

Respiratory distress syndrome of newborn

7.8

7.9

F32.10

ICD-10 Finland

Moderate depressive episode without somatic syndrome

1.6

7.9

199

1280

SAA03

NOMESCO Finland

Extended examination of mouth

1.3

7.8

871

7371

SPAT1222

SPAT

Counselling/guidance promoting independent living

1.6

7.8

209

1367

H52.4

ICD-10 Finland

Presbyopia

4.2

7.8

M79.1

ICD-10 Finland

Myalgia

1.6

7.8

224

1491

M01AX17

ATC

nimesulide; oral

1.5

7.8

257

1763

R26.8

ICD-10 Finland

Other and unspecified abnormalities of gait and mobility

3.6

7.7

L17

ICPC

Foot/toe symptom/complaint

1.4

7.7

432

3289

DM1QA

NOMESCO Finland

Paranasal sinuses X-ray examination in one projection

2.1

7.7

397

ZXE15

NOMESCO Finland

Procedure duration 120 to 149 minutes

2.3

7.7

297

G03BA03

ATC

testosterone; systemic, rectal, sublingual, transdermal

2.3

7.6

278

NFL22

NOMESCO Finland

Myotomy or tenotomy of hip or thigh

18.4

7.6

Z63.7

ICD-10 Finland

Other stressful life events affecting family and household

2.3

7.6

303

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

1.8

7.6

127

727

S18

ICPC

Laceration/cut

1.3

7.6

640

5203

N03AX22

ATC

perampanel; oral

8.9

7.5

F05

ICPC

Visual disturbance other

2.6

7.5

192

G04BD12

ATC

mirabegron; oral

1.9

7.4

107

580

XKC03

NOMESCO Finland

Water cystometry

2.6

7.4

198

AAF05

NOMESCO Finland

Ventriculoperitoneal shunt

5.6

7.4

ZXE11

NOMESCO Finland

Procedure duration 60 to 89 minutes

1.6

7.4

169

1062

H60.8

ICD-10 Finland

Other otitis externa

2.6

7.3

199

TPH07

NOMESCO Finland

Cathetrisation of artery

1.7

7.3

144

865

PH2AE

NOMESCO Finland

Ultrasound examination of lower leg veins

1.7

7.3

137

810

N03AG04

ATC

vigabatrin; oral

8.4

7.3

3671A

ICD-9 Finland

Disorders of refraction and accommodation, Myopia

+∞

7.3

J45.9

ICD-10 Finland

Asthma, unspecified

1.5

7.3

294

2105

N05AN01

ATC

lithium; oral

2.6

7.3

190

H54.5

ICD-10 Finland

Severe visual impairment, monocular

9.4

7.3

AA7AA

NOMESCO Finland

Liquor cerebri shunt X-ray examinatin without contrast

9.4

7.3

G91.0

ICD-10 Finland

Communicating hydrocephalus

9.4

7.3

SPAT1254

SPAT

Administration of medicine

1.4

7.2

303

2188

T36

ICD-10 Finland

Poisoning by systemic antibiotics

1.9

7.2

102

552

F80.1

ICD-10 Finland

Expressive language disorder

2.9

7.2

148

G81.9

ICD-10 Finland

Hemiplegia, unspecified

5.4

7.2

N39.4

ICD-10 Finland

Other specified urinary incontinence

2.0

7.2

470

37720

ICD-8 Finland

Other diseases of retina and optic nerve, Amblyopia

30.1

7.1

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

1.3

7.1

820

6943

N04BD01

ATC

selegiline; oral

4.8

7.1

N06AX12

ATC

bupropion; oral

1.7

7.1

137

816

H57.1

ICD-10 Finland

Ocular pain

2.2

7.1

294

Z3226

NOMESCO Finland

Physiotherapist

1.4

7.1

339

2509

AAF25

NOMESCO Finland

Removal of shunt of ventricle of brain

12.0

7.1

G40.4

ICD-10 Finland

Other generalized epilepsy and epileptic syndromes

6.0

7.1

R39.1

ICD-10 Finland

Other difficulties with micturition

2.8

7.1

151

R4110

NOMESCO Finland

Physiotherapy

1.4

7.0

422

3247

F70.9

ICD-10 Finland

Mild mental retardation, Without mention of impairment of behaviour

8.8

7.0

181

Kela drug reimbursment

Retigabine and vigabatrin

8.8

7.0

Q53.2

ICD-10 Finland

Undescended testicle, bilateral

10.0

7.0

Q21.11

ICD-10 Finland

Paten or persistent foramen ovale

4.3

7.0

N04BC04

ATC

ropinirole; oral

4.7

7.0

Q21.10

ICD-10 Finland

Persistent ostium secundum

3.2

7.0

107

A01

ICPC

Pain general/multiple sites

1.8

7.0

124

724

WZB00

NOMESCO Finland

Telephone receipt or other advice

1.3

7.0

539

4318

R62.8

ICD-10 Finland

Other lack of expected normal physiological development

4.0

7.0

N06BA04

ATC

methylphenidate; oral

1.9

6.9

477

SAA01

NOMESCO Finland

Simple examination of mouth

1.3

6.9

1472

13461

N06CA01

ATC

amitriptyline and psycholeptics; systemic

1.7

6.9

125

732

R11

ICD-10 Finland

Nausea and vomiting

1.6

6.9

160

1009

RT160

NOMESCO Finland

4.6

6.9

P07.2

ICD-10 Finland

Extreme immaturity

13.8

6.9

RL130

NOMESCO Finland

4.4

6.8

NA7CG

NOMESCO Finland

Spine and spinal cord extensive MRI examination with high intensity magnet

3.2

6.8

104

S01FA01

ATC

atropine; ophthalmic

11.0

6.8

K59.0

ICD-10 Finland

Constipation

1.9

6.8

476

XX4AW

NOMESCO Finland

3.6

6.8

H54.2

ICD-10 Finland

Moderate visual impairment, binocular

5.3

6.8

SPAT1148

SPAT

Treatment of chronic ulcer or burn

1.6

6.8

160

1015

F79

ICD-10 Finland

Unspecified mental retardation

16.7

6.7

H60.9

ICD-10 Finland

Otitis externa, unspecified

1.7

6.7

123

724

X69

ICD-10 Finland

Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances

2.0

6.7

399

R52.2

ICD-10 Finland

Other chronic pain

2.4

6.7

211

M25.5

ICD-10 Finland

Pain in joint

1.3

6.7

450

3525

N06AA10

ATC

nortriptyline; systemic

2.9

6.7

128

H47.7

ICD-10 Finland

Disorder of visual pathways, unspecified

22.6

6.7

SFA10

NOMESCO Finland

Fillning on one surface of tooth

1.3

6.6

1066

9390

E30.09

ICD-10 Finland

Delayed puberty NOS

7.8

6.6

N03AX18

ATC

lacosamide; systemic

4.2

6.6

101

Kela drug reimbursment

Anterior pituitary hypofunction

3.5

6.6

JN3AA

NOMESCO Finland

Abdominal X-ray examination without contrast

2.1

6.6

333

NA1BG

NOMESCO Finland

Cervical spine MRI examination with high intensity magnet

2.0

6.5

398

TNX33

NOMESCO Finland

Custom moulded cast, unspecified region

1.9

6.5

442

NK6MA

NOMESCO Finland

Measurement of bone age from hand and elbow using X-ray

2.2

6.5

302

G40.89

ICD-10 Finland

Other epilepsy

5.0

6.5

R13

ICD-10 Finland

Dysphagia

2.0

6.5

391

F33.9

ICD-10 Finland

Recurrent depressive disorder, unspecified

1.9

6.5

472

M54.5

ICD-10 Finland

Low back pain

1.3

6.4

531

4287

N31.0

ICD-10 Finland

Uninhibited neuropathic bladder, not elsewhere classified

7.4

6.4

NA1AD

NOMESCO Finland

Cervical spine CT examination

2.2

6.4

297

Q25.0

ICD-10 Finland

Patent ductus arteriosus

3.9

6.4

SPAT1234

SPAT

Support of social functional capacity

2.1

6.4

346

ZXD05

NOMESCO Finland

Urgent procedure

1.3

6.3

525

4238

WX704

NOMESCO Finland

Intubation

1.8

6.3

109

630

NA1CG

NOMESCO Finland

Cervical spine extensive MRI examination with high intensity magnet

3.2

6.3

NF1DA

NOMESCO Finland

X-ray of hips

3.2

6.3

SPAT1053

SPAT

Memory test

1.7

6.3

116

684

H06.2*E05.9

ICD-10 Finland

Dysthyroid exophthalmos

8.2

6.3

J20.9

ICD-10 Finland

Acute bronchitis, unspecified

1.4

6.3

275

1999

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

1.3

6.3

665

5546

F33.2

ICD-10 Finland

Recurrent depressive disorder, current episode severe without psychotic symptoms

1.8

6.3

535

F29

ICD-10 Finland

Unspecified nonorganic psychosis

1.9

6.3

476

H35.39

ICD-10 Finland

Degeneration of macula and posterior pole

3.3

6.3

XCW11

NOMESCO Finland

Assessment of strabismus

+∞

6.2

CEC90

NOMESCO Finland

Total transposition of extraocular muscle or muscles

+∞

6.2

N02AA05

ATC

oxycodone; systemic

1.6

6.2

140

878

H02AB09

ATC

hydrocortisone; systemic

2.2

6.2

286

G43.3

ICD-10 Finland

Complicated migraine

2.9

6.2

118

EBA05

NOMESCO Finland

Complicated extraction of tooth

1.4

6.2

285

2093

F45.4

ICD-10 Finland

Persistent somatoform pain disorder

3.2

6.2

ZY020

NOMESCO Finland

Telephone, letter or other consultation without direct patient contact

1.8

6.2

102

581

K04.5

ICD-10 Finland

Chronic apical periodontitis

1.4

6.2

334

2522

KAT00

NOMESCO Finland

Extracorporeal shock wave lithotripsy of pelvis of kidney

5.3

6.1

R1210

NOMESCO Finland

Medical assessment of need and possibilities to rehabilitation

3.2

6.1

EBA15

NOMESCO Finland

Extraction of large number of teeth

2.2

6.1

255

NJ3CG

NOMESCO Finland

Extensive MRI examination of extremities with median high magnet

7.7

6.1

P20

ICPC

Memory disturbance

1.8

6.1

523

AA1CM

NOMESCO Finland

Extensive MRI examination of brain with 3 Tesla magnet

2.6

6.1

153

K21.9

ICD-10 Finland

Gastro-oesophageal reflux disease without oesophagitis

1.7

6.1

129

793

TJD20

NOMESCO Finland

Change of gastrostomy tube

4.7

6.1

E0000UV

ATC

1.3

6.1

757

6443

G40.19

ICD-10 Finland

Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures

4.0

6.1

N05CF02

ATC

zolpidem; oral

1.5

6.1

242

1726

JDB10

NOMESCO Finland

Percutaneous gastrostomy

3.9

6.1

XJH00

NOMESCO Finland

Transanal ultrasonography

2.3

6.1

237

M03BX02

ATC

tizanidine; oral

1.3

6.1

954

8354

R41.8

ICD-10 Finland

Other and unspecified symptoms and signs involving cognitive functions and awareness

1.8

6.1

512

ICD-10 Finland

2.9

6.1

114

U04

ICPC

Incontinence urine

2.2

6.0

250

NAME	H7_INTERHETEROTRO
CONTROL_EXCLUDE	H7_OCUMUSCLE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H503
HD_ICD_9	3782
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H503
COD_ICD_9	3782
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Parameter	HR [95% CI]	p-value
H7_INTERHETEROTRO	1.207 [0.97, 1.5]	0.09
Birth year	0.999 [0.99, 1.01]	0.839

Parameter	HR [95% CI]	p-value
H7_INTERHETEROTRO	1.247 [1.01, 1.53]	0.036
Birth year	0.985 [0.98, 0.99]	0.002

N-year risk	Females	Males
1	0.137%	0.3%
5	0.895%	1.526%
10	2.02%	3.477%
15	3.824%	6.621%
20	6.883%	11.084%

Intermittent heterotropia

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints