Risteys · I9_OTHILLHEART

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — I51, I52* Hospital discharge: ICD-9 — 429 Hospital discharge: ICD-8 — 42899\|42999 Cause of death: ICD-10 — I51, I52* Cause of death: ICD-9 — 429 Cause of death: ICD-8 — 42899\|42999 2 out of 7 registries used, show all original rules.	2260
4. Check minimum number of events None	2260
5. Include endpoints None	2260
6. Filter based on genotype QC (FinnGen only)	2260

	All	Female	Male
Number of individuals
Whole population	33677	12205	20779
Only index persons	17579	6000	11579
Unadjusted period prevalence (%)
Whole population	0.50	0.35	0.58
Only index persons	0.37	0.22	0.44
Median age at first event (years)
Whole population	58.86	65.01	55.08
Only index persons	51.92	58.39	48.57

	All	Female	Male
Number of individuals	2260	826	1434
Unadjusted period prevalence (%)	0.50	0.28	0.63
Median age at first event (years)	55.06	54.70	55.27

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
1999: Matched controls
19996

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

I50.9

ICD-10 Finland

Heart failure, unspecified

84.9

323.0

402

I51.7

ICD-10 Finland

Cardiomegaly

4755.8

323.0

397

I48

ICD-10 Finland

Atrial fibrillation and flutter

90.9

323.0

479

I51.4

ICD-10 Finland

Myocarditis, unspecified

6048.1

323.0

787

207

Kela drug reimbursment

Chronic arrhythmias

130.2

273.7

290

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

8.9

264.0

636

999

FM1AE

NOMESCO Finland

Standard cardiac ultrasound examination

9.3

260.5

606

895

B01AA03

ATC

warfarin; systemic

9.3

241.0

555

794

I50.0

ICD-10 Finland

Congestive heart failure

218.3

227.6

232

FN1AC

NOMESCO Finland

Angiography of heart and/or coronary arteries

6.4

210.4

650

1404

C07AB07

ATC

bisoprolol; oral

4.5

207.9

1067

4038

I50.1

ICD-10 Finland

Left ventricular failure

1077.3

202.7

195

290

Kela drug reimbursment

Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation

249.2

199.5

202

XFP20

NOMESCO Finland

Check up of cardiac pacemaker

176.3

198.8

206

351

Kela drug reimbursment

Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation

+∞

186.4

176

C03CA01

ATC

furosemide; systemic

4.9

179.2

726

2088

201

Kela drug reimbursment

Chronic cardiac insufficiency

20.3

162.1

249

139

Z95.0

ICD-10 Finland

Presence of electronic cardiac devices

285.8

156.8

158

I51.9

ICD-10 Finland

Heart disease, unspecified

+∞

154.1

146

C01AA05

ATC

digoxin; systemic

15.3

142.6

244

180

I51.3

ICD-10 Finland

Intracardiac thrombosis, not elsewhere classified

+∞

137.0

130

TFP20

NOMESCO Finland

Cardiodefibrillation

113.2

136.0

147

I42.0

ICD-10 Finland

Dilated cardiomyopathy

+∞

134.9

128

I40.9

ICD-10 Finland

Acute myocarditis, unspecified

1296.4

126.5

122

Z45.0

ICD-10 Finland

Adjustment and management of cardiac devices

252.7

117.1

119

C03DA01

ATC

spironolactone; oral

7.0

113.8

304

501

FM1DG

NOMESCO Finland

Very extensive MRI examination of heart with high intesity magnet

125.2

110.3

118

AN1

Coronary angiography

6.0

108.9

330

641

GD1AA

NOMESCO Finland

Thorax X-ray examination

3.0

106.8

908

4374

XF404

NOMESCO Finland

Ambulatory ECG

9.8

104.9

222

251

I42.9

ICD-10 Finland

Cardiomyopathy, unspecified

1050.0

103.1

100

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

4.4

99.7

405

1080

42999

ICD-8 Finland

Ill-defined heart disease, Other and unspecified heart disease

+∞

97.7

I51.1

ICD-10 Finland

Rupture of chordae tendineae, not elsewhere classified

+∞

94.5

C01BD01

ATC

amiodarone; systemic

115.6

91.8

R07.4

ICD-10 Finland

Chest pain, unspecified

3.1

89.5

619

2526

I51.8

ICD-10 Finland

Other ill-defined heart diseases

+∞

83.9

I47.2

ICD-10 Finland

Ventricular tachycardia

413.4

80.5

I35.1

ICD-10 Finland

Aortic (valve) insufficiency

48.4

79.8

FJA10

NOMESCO Finland

Transvenous biopsy of right ventricle

798.3

78.9

I48.0

ICD-10 Finland

Paroxysmal atrial fibrillation

82.7

77.7

FPE20

NOMESCO Finland

Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes

263.1

74.9

I48.9

ICD-10 Finland

Atrial fibrillation and atrial flutter, unspecified

199.9

74.7

I34.09

ICD-10 Finland

Mitral (valve) insufficiency

94.9

74.5

FM1BE

NOMESCO Finland

Cardiac ultrasound examination through oesophagus

8.5

73.7

168

213

FM1DE

NOMESCO Finland

Doppler ultrasound examination of heart

6.5

73.7

203

341

I25.1

ICD-10 Finland

Atherosclerotic heart disease

3.1

72.7

484

1883

K78

ICPC

Atrial fibrillation/flutter

15.7

71.4

119

I49.3

ICD-10 Finland

Ventricular premature depolarization

15.7

69.6

116

I44.2

ICD-10 Finland

Atrioventricular block, complete

+∞

69.1

I49.5

ICD-10 Finland

Sick sinus syndrome

658.6

65.3

C09AA05

ATC

ramipril; oral

2.7

62.6

516

2271

I49.9

ICD-10 Finland

Cardiac arrhythmia, unspecified

6.0

62.4

183

332

XF400

NOMESCO Finland

ECG with 12 standard connections

3.1

61.8

396

1480

R06.0

ICD-10 Finland

Dyspnoea

2.7

60.8

485

2087

I35.0

ICD-10 Finland

Aortic (valve) stenosis

32.8

60.0

ZXD05

NOMESCO Finland

Urgent procedure

2.4

60.0

659

3384

TFC00

NOMESCO Finland

Catheterisation of right atrium or ventricle

60.3

59.9

B01AF02

ATC

apixaban; oral

8.8

58.8

130

156

TFP34

NOMESCO Finland

Electrophysiological investigation

289.2

55.5

4273A

ICD-9 Finland

Cardiac dysrhythmias, Atrial fibrillation and flutter

+∞

55.5

XF402

NOMESCO Finland

ECG with work load test

3.9

52.6

236

665

I34.00

ICD-10 Finland

Mitral (valve) incompetence NOS or of specified cause, except rheumatic

499.5

49.6

FPG32

NOMESCO Finland

Implantation of cardioverter-defibrillator with atrial and ventricular electrodes

+∞

49.1

4298A

ICD-9 Finland

Ill-defined descriptions and complications of heart disease, Other ill-defined heart diseases[ASTHENIA VASOREGULATORIA]

+∞

47.0

42899

ICD-8 Finland

Other myocardial insufficiency

+∞

47.0

GD1LA

NOMESCO Finland

88.9

47.0

I47.1

ICD-10 Finland

Supraventricular tachycardia

34.3

46.2

Angiography of the heart and coronary arteries

4.6

45.1

166

387

FN1BC

NOMESCO Finland

Extensive angiography of hear and/or coronary arteries

6.1

44.4

126

218

Z95.2

ICD-10 Finland

Presence of prosthetic heart valve

83.7

44.0

WX892

NOMESCO Finland

Monitored bed care

4.3

43.5

173

435

J18.9

ICD-10 Finland

Pneumonia, unspecified

2.2

43.2

516

2683

C01DA08

ATC

isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal

2.4

42.8

427

2030

I21.49

ICD-10 Finland

Acute subendocardial infarction unspecified coronary artery status

4.7

42.8

153

346

206

Kela drug reimbursment

Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease

2.5

42.0

382

1729

I51.0

ICD-10 Finland

Cardiac septal defect, acquired

+∞

41.8

I34.1

ICD-10 Finland

Mitral (valve) prolapse

43.5

41.4

I30.9

ICD-10 Finland

Acute pericarditis, unspecified

+∞

40.7

I42.8

ICD-10 Finland

Other cardiomyopathies

+∞

40.7

C07AB02

ATC

metoprolol; systemic

2.4

40.3

396

1862

C07AA07

ATC

sotalol; systemic

9.2

39.9

I51.5

ICD-10 Finland

Myocardial degeneration

+∞

39.7

4294A

ICD-9 Finland

Ill-defined descriptions and complications of heart disease, Functional disturbances following cardiac surgery

+∞

39.7

TFJ02

NOMESCO Finland

Muscle biopsy of heart

+∞

39.7

C01DA14

ATC

isosorbide mononitrate; oral

2.7

39.5

308

1275

I31.9

ICD-10 Finland

Disease of pericardium, unspecified

394.7

39.2

C01BC04

ATC

flecainide; systemic

104.5

37.8

I25.2

ICD-10 Finland

Old myocardial infarction

3.9

37.8

163

441

FPE00

NOMESCO Finland

Implantation of transvenous cardiac pacemaker with ventricular electrode

+∞

37.6

I46.0

ICD-10 Finland

Cardiac arrest with successful resuscitation

+∞

37.6

FXA00

NOMESCO Finland

Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure

7.4

37.0

126

I42.2

ICD-10 Finland

Other hypertrophic cardiomyopathy

193.4

36.9

I50

ICD-10 Finland

Heart failure

19.2

36.7

I49.0

ICD-10 Finland

Ventricular fibrillation and flutter

+∞

36.6

289

Kela drug reimbursment

Combination product containing sacubitril and valsartan

+∞

35.5

TK800

NOMESCO Finland

Hemodialysis

9.5

35.1

TPH15

NOMESCO Finland

Insertion of central venous catheter through external or internal jugular vein

4.2

34.4

137

344

FB1BD

NOMESCO Finland

Extensive CT examination of arteria pulmonalis

3.6

33.9

161

472

L04AA06

ATC

mycophenolic acid; systemic

9.3

33.2

TPH04

NOMESCO Finland

Cathetrisation of vein

2.2

33.0

383

1932

A12BA01

ATC

potassium chloride; oral

4.7

32.7

116

260

I44.1

ICD-10 Finland

Atrioventricular block, second degree

+∞

32.4

381

Kela drug reimbursment

Combination product containing sacubitril and valsartan

+∞

32.4

I41.8*D86.8

ICD-10 Finland

Sarcoid myocarditis

+∞

32.4

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

2.6

32.4

263

1107

H02AB06

ATC

prednisolone; systemic

1.8

32.0

820

5581

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

2.4

31.8

310

1438

A02BC02

ATC

pantoprazole; systemic

1.7

30.7

1097

8242

138

Kela drug reimbursment

Severe anaemia associated with chronic renal failure

7.9

30.3

C09DX04

ATC

valsartan and sacubitril; oral

+∞

30.3

FPE30

NOMESCO Finland

Replacement of transvenous cardiac pacemaker pulse generator

+∞

30.3

I49.4

ICD-10 Finland

Other and unspecified premature depolarization

10.3

30.2

XFE00

NOMESCO Finland

Epicardial ultrasonography

9.9

30.2

123

Kela drug reimbursment

Chronic disorders of vitamin D metabolism

7.6

30.0

WX872

NOMESCO Finland

Intensive care

4.6

29.6

107

245

127

Kela drug reimbursment

Transplant complication

9.1

28.7

A49.9

ICD-10 Finland

Bacterial infection, unspecified

2.7

28.6

210

832

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

2.4

28.4

271

1238

B33.2

ICD-10 Finland

Viral carditis

+∞

28.2

I48.2

ICD-10 Finland

Chronic atrial fibrillation

+∞

28.2

N18.9

ICD-10 Finland

Chronic kidney disease, unspecified

3.9

28.1

119

316

C01DA02

ATC

glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal

2.1

27.9

380

2041

I25.9

ICD-10 Finland

Chronic ischaemic heart disease, unspecified

2.8

27.8

188

708

I11.0

ICD-10 Finland

Hypertensive heart disease with (congestive) heart failure

78.7

27.8

I44.7

ICD-10 Finland

Left bundle-branch block, unspecified

43.1

27.8

I20.09

ICD-10 Finland

Unstable angina

3.8

27.5

121

333

AS4

Physiological pacemaker insertion DDD (R)

+∞

27.1

I15.1

ICD-10 Finland

Hypertension secondary to other renal disorders

10.1

27.0

ZX120

NOMESCO Finland

Intravenous

2.7

26.7

189

732

PH1AC

NOMESCO Finland

Flebography of over extremity with X-ray

98.0

26.7

Z2221

NOMESCO Finland

Medical doctor

1.9

26.3

486

2923

42798

ICD-8 Finland

Symptomatic heart disease, Alia arrhytmia definita

+∞

26.1

I33.0

ICD-10 Finland

Acute and subacute infective endocarditis

+∞

26.1

AP1

Catheterization of the left side of the heart

10.4

26.0

I48.1

ICD-10 Finland

Persistent atrial fibrillation

73.6

25.8

C08DA01

ATC

verapamil; systemic

5.6

25.6

140

F10.0

ICD-10 Finland

Mental and behavioural disorders due to use of alcohol, Acute intoxication

6.9

25.4

AA1AD

NOMESCO Finland

CT of head and brain

2.0

25.4

397

2241

TFB00

NOMESCO Finland

Cathetrisation of pulmonal artery

14.1

25.4

L04AD02

ATC

tacrolimus; systemic (calcineurin inhibitors)

17.0

25.3

R50.9

ICD-10 Finland

Fever, unspecified

2.2

25.0

268

1290

I63.4

ICD-10 Finland

Cerebral infarction due to embolism of cerebral arteries

9.3

25.0

R07.3

ICD-10 Finland

Other chest pain

2.7

24.8

178

695

1CX08

NOMESCO Finland

253.0

24.7

TFP35

NOMESCO Finland

Electroanatomical mapping

253.0

24.7

Z94.1

ICD-10 Finland

Heart transplant status

131.6

24.6

N05CF01

ATC

zopiclone; oral

1.8

24.0

565

3660

I41.8

ICD-10 Finland

Myocarditis in other diseases classified elsewhere

+∞

24.0

4298X

ICD-9 Finland

Ill-defined descriptions and complications of heart disease, Other ill-defined heart diseases[MORBUS CORDIS ALIA DEFINITA]

+∞

24.0

42700

ICD-8 Finland

Symptomatic heart disease, Congestive heart failure

+∞

24.0

FPG96

NOMESCO Finland

Other implantation of permanent cardioverter-defibrillator

+∞

24.0

I21.40

ICD-10 Finland

Acute subendocardial infarction no detected stenosis of the coronary artery

6.1

24.0

111

I35.2

ICD-10 Finland

Aortic (valve) stenosis with insufficiency

68.2

23.8

XF640

NOMESCO Finland

7.3

23.6

M04AA01

ATC

allopurinol; systemic

2.3

23.1

230

1070

I47.9

ICD-10 Finland

Paroxysmal tachycardia, unspecified

22.3

23.0

42792

ICD-8 Finland

Symptomatic heart disease, Fibrillatio auricularis

+∞

22.9

R4110

NOMESCO Finland

Physiotherapy

1.8

22.9

450

2743

Z03.5

ICD-10 Finland

Observation for other suspected cardiovascular diseases

3.0

22.9

137

476

FM1JR

NOMESCO Finland

Heart, extensive metabolic PET with CT

232.4

22.7

L04AX01

ATC

azathioprine; systemic

3.6

22.6

106

308

Z95.1

ICD-10 Finland

Presence of aortocoronary bypass graft

4.6

22.5

181

GD1PA

NOMESCO Finland

X-ray examination of the lungs in one projection

2.8

22.0

147

549

4289X

ICD-9 Finland

Heart failure, unspecified

+∞

21.9

FPG30

NOMESCO Finland

Implantation of cardioverter-defibrillator with ventricular electrode

+∞

21.9

FKB10

NOMESCO Finland

Annuloplasty of mitral valve for insufficiency using ring

+∞

21.9

I21.90

ICD-10 Finland

Myocardial infarction (acute) UNS no detected stenosis of the coronary artery

6.4

21.9

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

2.6

21.6

162

647

TFP30

NOMESCO Finland

Cathetric examination for cardiac arrythmia

222.2

21.6

I21.99

ICD-10 Finland

Myocardial infarction (acute) UNS unspecified coronary artery status

5.0

21.5

144

N17.9

ICD-10 Finland

Acute renal failure, unspecified

4.4

21.4

186

FM1CG

NOMESCO Finland

Extensive examination of hear with high intensity magnet

50.5

21.1

B01AB05

ATC

enoxaparin; parenteral

1.8

21.1

465

2936

I42.1

ICD-10 Finland

Obstructive hypertrophic cardiomyopathy

+∞

20.9

I25.5

ICD-10 Finland

Ischaemic cardiomyopathy

9.3

20.8

XF655

NOMESCO Finland

Measurement of heart muscle perfusion with exercise

5.2

20.5

126

5253

FHL

Cardiac lung machine

10.7

20.4

I25.0

ICD-10 Finland

Atherosclerotic cardiovascular disease, so described

3.4

20.2

101

309

ZXE20

NOMESCO Finland

More than three and less than five hours

2.1

20.1

247

1256

ZXE00

NOMESCO Finland

One hour or less

1.6

19.9

652

4591

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

2.0

19.9

294

1613

AQ1

Conventional electrophysiological examination

+∞

19.8

TFC25

NOMESCO Finland

Transseptal catheterisation of left atrium or ventricle

+∞

19.8

I20.81

ICD-10 Finland

Other angina pectoris stenosed coronary artery

2.8

19.8

133

499

FL1AC

NOMESCO Finland

Left cardioangiography

7.4

19.8

I36.1

ICD-10 Finland

Nonrheumatic tricuspid (valve) insufficiency

74.2

19.7

R02

ICPC

Shortness of breath/dyspnoea

2.4

19.6

179

797

K80

ICPC

Cardiac arrhythmia NOS

3.5

19.1

274

K84

ICPC

Heart disease other

6.6

19.0

I11.9

ICD-10 Finland

Hypertensive heart disease without (congestive) heart failure

4.2

19.0

179

Z3231

NOMESCO Finland

Registered nurse

1.7

18.8

465

3022

A11CC03

ATC

alfacalcidol; systemic

5.5

18.8

105

Z94.0

ICD-10 Finland

Kidney transplant status

8.3

18.7

TPH07

NOMESCO Finland

Cathetrisation of artery

2.3

18.7

173

775

R00.0

ICD-10 Finland

Tachycardia, unspecified

4.1

18.6

183

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

1.7

18.4

481

3175

J15.9

ICD-10 Finland

Bacterial pneumonia, unspecified

2.3

18.3

175

795

N05BA04

ATC

oxazepam; oral

1.7

18.2

400

2506

DM1QA

NOMESCO Finland

Paranasal sinuses X-ray examination in one projection

3.3

18.1

286

R03AC02

ATC

salbutamol; inhalant

1.5

18.1

842

6427

C03EB01

ATC

furosemide and potassium-sparing agents; systemic

3.4

17.9

272

L04AD01

ATC

ciclosporin; systemic

5.3

17.7

104

FPE37

NOMESCO Finland

Implantation of biventricular cardioverter-defibrillator with atrial and ventricular electrodes

+∞

17.7

J20.9

ICD-10 Finland

Acute bronchitis, unspecified

1.9

17.5

283

1603

PBL10

NOMESCO Finland

Construction of arteriovenous fistula from radial artery

10.1

17.4

B01AC04

ATC

clopidogrel; oral

2.0

17.4

243

1303

J06.9

ICD-10 Finland

Acute upper respiratory infection, unspecified

1.6

17.3

679

4966

Z01.8

ICD-10 Finland

Other specified special examinations

1.8

17.0

335

2024

TFP00

NOMESCO Finland

Temporary use of transvenous or epicardial pacemaker

31.7

17.0

K77

ICPC

Heart failure

11.6

17.0

K83

ICPC

Heart valve disease NOS

50.4

17.0

H02AB04

ATC

methylprednisolone; systemic

2.0

17.0

248

1352

I44.0

ICD-10 Finland

Atrioventricular block, first degree

22.0

16.9

N05BA01

ATC

diazepam; systemic, rectal

2.0

16.8

239

1290

I51.6

ICD-10 Finland

Cardiovascular disease, unspecified

+∞

16.7

XF409

NOMESCO Finland

Other special ECG

+∞

16.7

I40.8

ICD-10 Finland

Other acute myocarditis

+∞

16.7

4293A

ICD-9 Finland

Ill-defined descriptions and complications of heart disease, Cardiomegaly

+∞

16.7

I40.0

ICD-10 Finland

Infective myocarditis

+∞

16.7

C09AA02

ATC

enalapril; systemic

1.8

16.6

331

2007

AP4

Myocardial biopsy

90.8

16.6

4019X

ICD-9 Finland

Essential hypertension, Unspecified

3.8

16.5

188

I34.0

ICD-10 Finland

Mitral (valve) insufficiency

27.8

16.5

Z49.1

ICD-10 Finland

Extracorporeal dialysis

9.6

16.4

KAS10

NOMESCO Finland

Allogenic transplantation of kidney from cadaver donor

9.6

16.4

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

1.7

16.4

438

2897

4130X

ICD-9 Finland

Angina pectoris, Angina decubitus[ANGINA PECTORIS (""""EFFORT ANGINA""""),MÄÄRITTELEMÄT]

4.5

16.2

129

A12AA04

ATC

calcium carbonate; oral

6.6

16.1

I20.90

ICD-10 Finland

Angina pectoris, unspecified

3.6

15.9

205

N02AX02

ATC

tramadol; systemic, rectal

1.5

15.7

695

5192

R53

ICD-10 Finland

Malaise and fatigue

1.8

15.7

314

1903

I30.0

ICD-10 Finland

Acute nonspecific idiopathic pericarditis

+∞

15.6

TFP46

NOMESCO Finland

Ablation treatment of atrial fibrillation

+∞

15.6

4299X

ICD-9 Finland

Ill-defined descriptions and complications of heart disease, Heart disease, unspecified

+∞

15.6

F10.1

ICD-10 Finland

Mental and behavioural disorders due to use of alcohol, Harmful use

2.4

15.6

134

578

Electrophysiological Special Examination

85.7

15.6

J01MA14

ATC

moxifloxacin; systemic

2.2

15.2

152

706

I45.9

ICD-10 Finland

Conduction disorder, unspecified

45.3

15.1

R00.2

ICD-10 Finland

Palpitations

2.8

15.0

349

E11.7

ICD-10 Finland

Type 2 diabetes mellitus, with multiple complications

3.1

14.9

272

C10AA01

ATC

simvastatin; oral

1.5

14.8

671

5025

N18.8

ICD-10 Finland

Other chronic renal failure

4.3

14.8

132

SPAT1097

SPAT

Recording of ECG

1.9

14.7

213

1156

J01FA06

ATC

roxithromycin; oral

1.5

14.7

640

4750

FQA10

NOMESCO Finland

Orthotopic transplantation of heart with bicaval anastomosis

+∞

14.6

I33.9

ICD-10 Finland

Acute endocarditis, unspecified

+∞

14.6

FMD00

NOMESCO Finland

Replacement of aortic valve using mechanical prosthesis

+∞

14.6

I20.99

ICD-10 Finland

Angina pectoris, unspecified

2.7

14.6

105

409

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

2.7

14.6

368

H02AB07

ATC

prednisone; oral

1.9

14.5

237

1344

I21.41

ICD-10 Finland

Acute subendocardial infarction stenosed coronary artery

3.1

14.1

268

A98

ICPC

Health maint/preventive medicine

0.7

14.1

1449

15999

213

Kela drug reimbursment

Fat metabolism disorder associated with chronic coronary artery disease

2.3

14.0

126

556

J01FF01

ATC

clindamycin; systemic

1.6

14.0

418

2835

N19

ICD-10 Finland

Unspecified kidney failure

3.7

13.9

165

3AC01

NOMESCO Finland

7.8

13.8

B01AE07

ATC

dabigatran etexilate; oral

5.1

13.8

4130B

ICD-9 Finland

Angina pectoris, Angina decubitus[ANGINA PECTORIS (""""EFFORT ANGINA""""),AHTAUTUNUT]

4.8

13.8

F10.2

ICD-10 Finland

Mental and behavioural disorders due to use of alcohol, Dependence syndrome

5.8

13.8

I35.9

ICD-10 Finland

Aortic valve disorder, unspecified

+∞

13.5

TFP32

NOMESCO Finland

Cathetric treatmen of cardiac arrythmia

+∞

13.5

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

2.1

13.5

151

738

B03XA02

ATC

darbepoetin alfa; parenteral

5.3

13.5

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

1.5

13.4

485

3440

UJF32

NOMESCO Finland

Coloscopy

1.6

13.4

378

2522

I49.1

ICD-10 Finland

Atrial premature depolarization

8.2

13.3

I70.2

ICD-10 Finland

Atherosclerosis of arteries of extremities

2.1

13.3

147

717

N18.0

ICD-10 Finland

End-stage renal disease

7.3

13.2

Z2446

NOMESCO Finland

Social worker

2.3

13.2

121

538

R55

ICD-10 Finland

Syncope and collapse

2.0

13.1

167

860

205

Kela drug reimbursment

Chronic hypertension

1.5

13.1

462

3250

I21.97

ICD-10 Finland

Suspected acute myocardial infarction

7.9

13.1

4120B

ICD-9 Finland

Old myocardial infarction[STATUS POST INFARCTUM CORDIS,AHTAUTUNUT]

6.8

13.0

E78.5

ICD-10 Finland

Hyperlipidaemia, unspecified

2.1

12.9

148

731

A41.0

ICD-10 Finland

Sepsis due to Staphylococcus aureus

4.4

12.9

107

R04.0

ICD-10 Finland

Epistaxis

2.3

12.7

113

497

J01MA12

ATC

levofloxacin; systemic

1.7

12.7

294

1854

I26.9

ICD-10 Finland

Pulmonary embolism without mention of acute cor pulmonale

2.5

12.7

392

GD1DD

NOMESCO Finland

High resolution CT examination of lungs

2.8

12.7

285

I20.00

ICD-10 Finland

Unstable angina

3.7

12.5

144

D64.9

ICD-10 Finland

Anaemia, unspecified

2.0

12.5

156

796

190

Kela drug reimbursment

Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide

11.1

12.5

FKD10

NOMESCO Finland

Replacement of mitral valve using biological prosthesis

+∞

12.5

FPH10

NOMESCO Finland

Open removal of transvenous cardiac pacemaker or cardioverter-defibrillator

+∞

12.5

J01EE01

ATC

sulfamethoxazole and trimethoprim; systemic

2.3

12.3

110

485

XF600

NOMESCO Finland

Bloodpressure measurement

2.4

12.3

104

446

J01AA02

ATC

doxycycline; systemic

1.4

12.2

1302

11356

A41.9

ICD-10 Finland

Sepsis, unspecified

3.0

12.0

236

I71.2

ICD-10 Finland

Thoracic aortic aneurysm, without mention of rupture

5.1

12.0

FWD00

NOMESCO Finland

Reoperation for superficial haemorrhage in surgery of heart and major thoracic vessels

11.8

5314

FHL

Bypass surgery for four or more vessels

8.4

11.8

ZXD10

NOMESCO Finland

Scheduled procedure

1.4

11.7

604

4600

KH1AE

NOMESCO Finland

Urinary tract ultrasound examination

2.5

11.6

394

K99

ICPC

Cardiovascular disease other

4.4

11.6

KA2AE

NOMESCO Finland

Ultrasound examination transplanted kidney

8.7

11.5

I71.9

ICD-10 Finland

Aortic aneurysm of unspecified site, without mention of rupture

5.9

11.5

I42

ICD-10 Finland

Cardiomyopathy

+∞

11.5

I31.8

ICD-10 Finland

Other specified diseases of pericardium

+∞

11.5

I34.9

ICD-10 Finland

Nonrheumatic mitral valve disorder, unspecified

120.6

11.4

PD5BD

NOMESCO Finland

Extensive CT of aorta

4.6

11.4

137

Kela drug reimbursment

Uraemia requiring dialysis

7.9

11.3

J90

ICD-10 Finland

Pleural effusion, not elsewhere classified

3.1

11.3

207

TKC20

NOMESCO Finland

Catheterisation of bladder

2.2

11.3

119

569

GA4YT

NOMESCO Finland

Puncture of pleura with ultrasound guidance

4.0

11.3

112

K70.0

ICD-10 Finland

Alcoholic fatty liver

6.6

11.3

D86.8

ICD-10 Finland

Sarcoidosis of other and combined sites

8.9

11.2

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

1.9

11.0

165

905

I63.9

ICD-10 Finland

Cerebral infarction, unspecified

1.9

10.9

170

947

C08DB01

ATC

diltiazem; oral

2.3

10.8

416

J46

ICD-10 Finland

Status asthmaticus

3.7

10.8

127

FNC20

NOMESCO Finland

Aorto-coronary venous bypass with two distal anastomoses

4.3

10.8

ZXE03

NOMESCO Finland

Procedure duration 20 to 29 minutes

2.3

10.7

102

466

G47.3

ICD-10 Finland

Sleep apnoea

1.6

10.7

314

2108

R00.1

ICD-10 Finland

Bradycardia, unspecified

4.4

10.6

Catheterization and pressure measurement of the left side of the heart

4.4

10.6

Z3226

NOMESCO Finland

Physiotherapist

1.6

10.6

284

1863

N06AX11

ATC

mirtazapine; oral

1.5

10.5

464

3410

QDB10

NOMESCO Finland

Major dressing of wound of skin of lower limb

2.5

10.5

333

7AX01

NOMESCO Finland

110.5

10.4

FPE96

NOMESCO Finland

Other implantation or replacement of transvenous cardiac pacemaker

110.5

10.4

342

Kela drug reimbursment

Dronedarone

+∞

10.4

FXL00

NOMESCO Finland

Insertion and use of extra-, para- or intracorporeal VAD

+∞

10.4

4276B

ICD-9 Finland

Cardiac dysrhythmias, Premature beats[EXTRASYSTOLIA VENTRICULARIS]

+∞

10.4

AS8

Physiological arrhythmia pacemaker insertionDDD (R) S

+∞

10.4

C07AA05

ATC

propranolol; systemic

1.6

10.4

264

1708

A46

ICD-10 Finland

Erysipelas

1.7

10.3

203

1217

TPH90

NOMESCO Finland

Removal of fixed intravenous catheter

4.7

10.3

J45.9

ICD-10 Finland

Asthma, unspecified

1.6

10.3

252

1610

FN1CC

NOMESCO Finland

Very extensive angiography of heart and/or coronary arteries

5.8

10.3

5315

FHL

Bypass surgery using a mammary artery

5.5

10.3

DM1AA

NOMESCO Finland

Paranasal sinuses X-ray examination without contrast

3.1

10.2

182

A02BC03

ATC

lansoprazole; oral

1.5

10.2

433

3155

Coronary artery bypass surgery

3.5

10.1

129

J01CA04

ATC

amoxicillin; systemic

1.4

10.1

1354

12055

B03XA03

ATC

methoxy polyethylene glycol-epoetin beta; parenteral

10.1

10.0

Q21.19

ICD-10 Finland

Atrial septal defect NOS

40.2

10.0

M10.9

ICD-10 Finland

Gout, unspecified

2.2

9.9

436

C07AG02

ATC

carvedilol; oral

2.3

9.9

383

B01AC06

ATC

acetylsalicylic acid; oral (platelet aggregation inhibitors excl. heparin)

2.6

9.9

273

FN1BT

NOMESCO Finland

Extensive endovascular dilatation of coronary (PTCA) arteries

3.7

9.9

116

R03BB04

ATC

tiotropium bromide; inhalant

1.9

9.9

157

879

203

Kela drug reimbursment

Chronic asthma and similar chronic obstructive pulmonary diseases

1.6

9.8

308

2095

FNA01

NOMESCO Finland

Anastomosis to coronary artery from internal mammary artery, one distal anastamosis

2.7

9.8

250

A10AC01

ATC

insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)

2.0

9.8

131

689

Z95.5

ICD-10 Finland

Presence of coronary angioplasty implant and graft

3.0

9.7

183

WX722

NOMESCO Finland

PEEP

2.5

9.7

296

C08CA05

ATC

nifedipine; systemic

2.1

9.6

109

538

C10AA05

ATC

atorvastatin; oral

1.4

9.6

532

4075

4120X

ICD-9 Finland

Old myocardial infarction[STATUS POST INFARCTUM CORDIS,MÄÄRITTELEMÄT]

4.3

9.6

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

1.6

9.6

256

1676

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

1.4

9.5

686

5502

N02BE01

ATC

paracetamol; systemic, rectal

1.4

9.5

1417

12763

QDB05

NOMESCO Finland

Revision of wound of skin of lower limb

3.5

9.5

126

J01CR02

ATC

amoxicillin and beta-lactamase inhibitor; systemic

1.4

9.5

775

6347

FPE40

NOMESCO Finland

Replacement of transvenous cardiac pacemaker electrode

100.4

9.4

FMD10

NOMESCO Finland

Replacement of aortic valve using biological prosthesis

+∞

9.4

AS7

Arrhythmia pacemaker insertion VVI (R) S

+∞

9.4

Initial pacemaker installation

+∞

9.4

FKC50

NOMESCO Finland

Repair of mitral valve for insufficiency using prosthetic chord

+∞

9.4

FXF00

NOMESCO Finland

Decannulation after ECHLA or ECLA

+∞

9.4

TFP47

NOMESCO Finland

Ablation or modification of the AV-node

+∞

9.4

FK1BT

NOMESCO Finland

Implantation of cardiac pacemaker with X-ray guidance

+∞

9.4

FM1DM

NOMESCO Finland

Heart very extensive MRI examination with 3 Tesla magnet

+∞

9.4

I34.01

ICD-10 Finland

Mitral (valve) regurgitation NOS or of specified cause, except rheumatic

+∞

9.4

UGC12

NOMESCO Finland

Flexible bronchoscopy

2.0

9.3

126

666

WX882

NOMESCO Finland

High dependency care

3.3

9.3

138

N06AB04

ATC

citalopram; systemic

1.5

9.3

322

2240

PA6BD

NOMESCO Finland

Extensive CT of neck arteries

2.7

9.3

230

GD1AD

NOMESCO Finland

Thorax CT examination

2.7

9.3

242

PH2AE

NOMESCO Finland

Ultrasound examination of lower leg veins

1.8

9.2

150

846

C02EA02

ATC

2.3

9.2

344

ZXE02

NOMESCO Finland

Procedure duration 10 to 19 minutes

2.3

9.2

364

WX404

NOMESCO Finland

Intravenous generell anesthesy

1.6

9.2

275

1848

N10

ICD-10 Finland

Acute tubulo-interstitial nephritis

1.7

9.1

184

1114

WX408

NOMESCO Finland

General anesthesy, balanced

1.5

9.1

402

2942

I69.3

ICD-10 Finland

Sequelae of cerebral infarction

2.0

9.1

110

558

N05CD07

ATC

temazepam; oral

1.7

9.1

205

1282

R03AK06

ATC

salmeterol and fluticasone; inhalant

1.7

9.1

209

1312

SPAT1253

SPAT

Initiation, adjustment, discontinuation or repetition of medication

1.4

9.0

419

3098

R07.2

ICD-10 Finland

Precordial pain

3.7

9.0

100

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

1.4

9.0

510

3917

R56.8

ICD-10 Finland

Other and unspecified convulsions

2.2

9.0

409

J45.1

ICD-10 Finland

Nonallergic asthma

2.1

9.0

106

531

KA2AT

NOMESCO Finland

Biopsy of transplanted kidney with ultrasound guidance

7.5

8.9

ZXE10

NOMESCO Finland

More than one and less than three hours

1.4

8.9

544

4234

A11

ICPC

Chest pain NOS

2.1

8.8

101

504

J01DA01

ATC

[U] cefalexin; systemic

1.3

8.7

1035

8931

XG412

NOMESCO Finland

Flow-volume spirometry with bronchospasmolysis

2.2

8.7

399

B05DA

ATC

Isotonic solutions

7.2

8.7

I20.89

ICD-10 Finland

Other angina pectoris unspecified coronary artery status

2.7

8.7

226

X69

ICD-10 Finland

Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances

2.7

8.7

226

B01AF03

ATC

edoxaban; oral

14.1

8.7

N39.0

ICD-10 Finland

Urinary tract infection, site not specified

1.7

8.5

185

1143

R51.80

ICD-10 Finland

Headache

1.7

8.5

196

1229

K29

ICPC

Cardiovascular sympt/complt other

2.7

8.5

212

N05AA02

ATC

levomepromazine; systemic

2.3

8.5

345

AP2

Catheterization of the right side of the heart

20.1

8.5

I45.3

ICD-10 Finland

Trifascicular block

90.4

8.4

I40

ICD-10 Finland

Acute myocarditis

90.4

8.4

WX002

NOMESCO Finland

Sedation and analgesia

1.5

8.4

276

1896

J45.0

ICD-10 Finland

Predominantly allergic asthma

1.9

8.4

126

694

J01DB01

ATC

cefalexin; oral

1.3

8.4

1355

12211

I51.2

ICD-10 Finland

Rupture of papillary muscle, not elsewhere classified

+∞

8.3

Initial installation of the atrial pacemaker

+∞

8.3

Catheter ablation of arrhythmia

+∞

8.3

FPJ24

NOMESCO Finland

Revision of biventricular cardioverter-defibrillator with atrial and ventricular electrodes

+∞

8.3

I48.3

ICD-10 Finland

Typical atrial flutter

+∞

8.3

4240A

ICD-9 Finland

Other diseases of endocardium, Mitral valve disorders[INSUFFICIENTIA VALVULAE MITRALIS (NON RHEUMATICA)]

+∞

8.3

4240B

ICD-9 Finland

Other diseases of endocardium, Mitral valve disorders[PROLAPSUS VALVULAE MITRALIS (SYNDROMA BARLOW)]

+∞

8.3

J44.8

ICD-10 Finland

Other specified chronic obstructive pulmonary disease

1.7

8.3

168

1018

XF620

NOMESCO Finland

Examination of circulation with color method

10.8

8.3

Z49.0

ICD-10 Finland

Preparatory care for dialysis

5.8

8.3

D50.9

ICD-10 Finland

Iron deficiency anaemia, unspecified

2.0

8.3

500

TPH20

NOMESCO Finland

Insertion of central venous catheter through subclavian or brachiocephalic vein

2.9

8.1

164

Q61.2

ICD-10 Finland

Polycystic kidney, autosomal dominant

8.1

FCA60

NOMESCO Finland

Resection of aortic root and ascending aorta with reimplantation of coronary arteries and use of composite graft with mechanical valve prosthesis

33.5

8.1

Q23.11

ICD-10 Finland

Bicuspid aortic valve

22.1

8.0

WX890

NOMESCO Finland

Intesive care monitoring

6.3

8.0

4148X

ICD-9 Finland

Other forms of chronic ischaemic heart disease, Other specified forms of chronic ischaemic heart disease[MORBUS CORDIS ISCHAEMICUS ALIA,MÄÄRITTELEMÄT]

5.9

8.0

GD2SN

NOMESCO Finland

Lung ventilation SPECT

7.8

7.9

PH1AE

NOMESCO Finland

Ultrasound examination of upper extremity veins

3.9

7.8

N08.39*E10.2

ICD-10 Finland

Insulin-dependent diabetes mellitus - Diabetic nephropathy

6.1

7.8

GD1UN

NOMESCO Finland

Lung circulation SPECT

8.5

7.8

T81.0

ICD-10 Finland

Haemorrhage and haematoma complicating a procedure, not elsewhere classified

2.1

7.8

430

AJ1

Reconstruction of the aortic base, eg composite graft, incl. valve saving operation

45.1

7.7

AS2

Ventricular pacemaker insertion VVI (R)

45.1

7.7

FPW96

NOMESCO Finland

Other operation for arhythmia or disturbance of impulse propagation

15.1

7.7

XG410

NOMESCO Finland

Flow-volume spirometry

2.4

7.7

258

A02BA04

ATC

nizatidine; systemic

1.8

7.7

124

702

XFN00

NOMESCO Finland

Inside imaging of coronary arteries??

8.0

7.6

T36

ICD-10 Finland

Poisoning by systemic antibiotics

2.3

7.6

304

Catheterization and pressure measurement of the right side of the heart

25.1

7.6

K52.9

ICD-10 Finland

Noninfective gastroenteritis and colitis, unspecified

2.4

7.6

245

E87.5

ICD-10 Finland

Hyperkalaemia

4.0

7.6

ZX108

NOMESCO Finland

Inhalation

6.2

7.5

J01FA10

ATC

azithromycin; systemic

1.3

7.5

871

7431

R42

ICD-10 Finland

Dizziness and giddiness

1.5

7.5

280

1976

C08CA01

ATC

amlodipine; oral

1.4

7.5

500

3927

N17.0

ICD-10 Finland

Acute renal failure with tubular necrosis

7.1

7.5

TK810

NOMESCO Finland

Hemofiltration

7.1

7.5

41399

ICD-8 Finland

Angina pectoris, Without mention of hypertensive disease

4.8

7.4

F10.31

ICD-10 Finland

Withdrawal symptoms caused by alcohol with seizures

4.8

7.4

FN1YT

NOMESCO Finland

Percutaneous insertion of coronary artery stent

2.2

7.4

355

SPAT1148

SPAT

Treatment of chronic ulcer or burn

1.6

7.4

179

1142

J01EE02

ATC

sulfadiazine and trimethoprim; systemic

1.4

7.4

431

3312

I44.4

ICD-10 Finland

Left anterior fascicular block

80.3

7.4

Z95.4

ICD-10 Finland

Presence of other heart-valve replacement

80.3

7.4

I34.2

ICD-10 Finland

Nonrheumatic mitral (valve) stenosis

80.3

7.4

N03AX16

ATC

pregabalin; oral

1.5

7.4

311

2250

N05AH04

ATC

quetiapine; oral

1.5

7.4

241

1653

L04AA01

ATC

[U] ciclosporin; systemic

3.8

7.3

K04

ICPC

Palpitations/awareness of heart

2.6

7.3

189

N30.0

ICD-10 Finland

Acute cystitis

1.7

7.3

165

1031

SPAT1254

SPAT

Administration of medicine

1.6

7.3

202

1330

E66.8

ICD-10 Finland

Other obesity

2.3

7.3

284

Aortic Valve Replacement (AVR)

+∞

7.3

TFP44

NOMESCO Finland

Ablation treatment of typical atrial flutter

+∞

7.3

250

Kela drug reimbursment

+∞

7.3

I31.3

ICD-10 Finland

Pericardial effusion (noninflammatory)

+∞

7.3

FKD00

NOMESCO Finland

Replacement of mitral valve using mechanical prosthesis

+∞

7.3

TFP40

NOMESCO Finland

Ablation treatment for a-v node re-entry activation

+∞

7.3

AB1

AVR mechanical

+∞

7.3

TFP52

NOMESCO Finland

Ablation treatment of ventricular tachycardia due to structural heart defect

+∞

7.3

C01BD07

ATC

dronedarone; oral

+∞

7.3

I40.1

ICD-10 Finland

Isolated myocarditis

+∞

7.3

AC4

MVP

+∞

7.3

FN1BB

NOMESCO Finland

Contrast angiography of heart and/or coronary arteries after bypass surgery

9.4

7.3

N25.8

ICD-10 Finland

Other disorders resulting from impaired renal tubular function

9.4

7.3

3050A

ICD-9 Finland

Nondependent abuse of drugs, Alcohol abuse

4.0

7.3

AN3

Balloon angioplasty and metallic stent

2.8

7.3

154

WX740

NOMESCO Finland

Nitrogen oxide therapy

15.8

7.2

R03BA05

ATC

fluticasone; inhalant

1.5

7.2

257

1798

C03EA01

ATC

hydrochlorothiazide and potassium-sparing agents; oral

1.5

7.2

214

1434

R11

ICD-10 Finland

Nausea and vomiting

1.8

7.2

113

635

B05DB

ATC

Hypertonic solutions

7.3

7.2

XPX99

NOMESCO Finland

Other diagnostic examination of periferal vessel

2.0

7.2

459

E11.8

ICD-10 Finland

Type 2 diabetes mellitus, with unspecified complications

1.8

7.2

122

704

A02BC05

ATC

esomeprazole; systemic

1.3

7.2

572

4618

I49.8

ICD-10 Finland

Other specified cardiac arrhythmias

3.8

7.2

C01BA03

ATC

disopyramide; systemic

20.1

7.1

JAK10

NOMESCO Finland

Laparotomy and insertion of peritoneal dialysis catheter

7.9

7.1

F10.00

ICD-10 Finland

Alcohol-related acute intoxication uncomplicated

3.1

7.1

117

B01AF01

ATC

rivaroxaban; oral

1.8

7.1

112

631

I20.01

ICD-10 Finland

Unstable angina

2.9

7.1

144

FM1LE

NOMESCO Finland

Combined ultrasound and EKG examination of heart with tolerance test

12.1

7.1

K01

ICPC

Heart pain

4.5

7.1

WX730

NOMESCO Finland

Conventional respirator

3.7

7.1

PA6DE

NOMESCO Finland

Neck artery ultrasound examination with Doppler method

2.3

7.0

276

A02BC01

ATC

omeprazole; systemic

1.4

6.9

403

3094

ZXE60

NOMESCO Finland

More than 12 and less than 15 hours

6.3

6.9

P01AB01

ATC

metronidazole; oral, rectal

1.3

6.9

537

4316

I97.0

ICD-10 Finland

Postcardiotomy syndrome

13.8

6.9

WX000

NOMESCO Finland

Monitoring vital functions without anesthesy

2.4

6.9

241

ZXE50

NOMESCO Finland

More than nine and less than 12 hours

4.1

6.9

M05BA04

ATC

alendronic acid; oral

1.8

6.8

108

608

JN3BD

NOMESCO Finland

Extensive abdominal CT

1.7

6.8

149

927

J01MA02

ATC

ciprofloxacin; systemic

1.3

6.8

588

4798

C02AC05

ATC

moxonidine; oral

2.3

6.8

267

N05BA12

ATC

alprazolam; oral

1.7

6.8

137

831

Q21.10

ICD-10 Finland

Persistent ostium secundum

9.3

6.8

C08CA07

ATC

nisoldipine; oral

4.0

6.8

FXD00

NOMESCO Finland

Use of ECHLA without concurrent surgical procedure

40.2

6.8

GAE10

NOMESCO Finland

Closure of previous incision of chest wall

40.2

6.8

Z95.8

ICD-10 Finland

Presence of other cardiac and vascular implants and grafts

16.7

6.7

FP4B5

NOMESCO Finland

ECG, prolonged recording (24 h)

16.7

6.7

I25

ICD-10 Finland

Chronic ischaemic heart disease

2.2

6.7

314

SPAT1104

SPAT

Monitoring of emergency patient

2.0

6.7

440

F41.9

ICD-10 Finland

Anxiety disorder, unspecified

1.8

6.7

110

625

F19.0

ICD-10 Finland

Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, acute intoxication

22.6

6.7

Z04.8

ICD-10 Finland

Examination and observation for other specified reasons

1.6

6.6

158

1002

N08.39

ICD-10 Finland

Glomerular disorders in diabetes mellitus microalbuminuria

7.8

6.6

196

Kela drug reimbursment

Paricalcitol and cinacalcet

12.3

6.6

J81

ICD-10 Finland

Pulmonary oedema

8.7

6.5

320

Kela drug reimbursment

Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide

10.0

6.5

X45

ICD-10 Finland

Accidental poisoning by and exposure to alcohol

5.7

6.4

C09AA04

ATC

perindopril; oral

2.0

6.4

379

5311

FHL

Bypass surgery in one vein

70.0

6.4

I45.6

ICD-10 Finland

Pre-excitation syndrome

70.0

6.4

FN1CD

NOMESCO Finland

Very extensive CT of coronary arteries

7.4

6.4

PG5RT

NOMESCO Finland

PTA of arterio-venous shunt for dialysis

14.3

6.4

GD1ED

NOMESCO Finland

Extensive high resolution CT examination of lungs

2.6

6.4

161

I21.00

ICD-10 Finland

Acute transmural myocardial infarction of anterior wall

3.5

6.4

N05AN01

ATC

lithium; oral

2.7

6.4

144

C10AA03

ATC

pravastatin; oral

1.9

6.4

497

UJF30

NOMESCO Finland

Ileoscopy through colon

1.7

6.3

123

739

A41.1

ICD-10 Finland

Sepsis due to other specified staphylococcus

6.6

6.3

M79.6

ICD-10 Finland

Pain in limb

1.3

6.3

480

3839

Z49.2

ICD-10 Finland

Other dialysis

5.5

6.3

J44.1

ICD-10 Finland

Chronic obstructive pulmonary disease with acute exacerbation, unspecified

2.6

6.3

170

Z71.3

ICD-10 Finland

Dietary counselling and surveillance

2.1

6.3

327

5AB14

NOMESCO Finland

18.1

6.3

I45.0

ICD-10 Finland

Right fascicular block

18.1

6.3

FM1AD

NOMESCO Finland

CT of heart

+∞

6.2

I46.9

ICD-10 Finland

Cardiac arrest, unspecified

+∞

6.2

4241A

ICD-9 Finland

Other diseases of endocardium, Aortic valve disorders[INSUFFICIENTIA VALVULAE AORTAE (NON RHEUMATICA)]

+∞

6.2

FKC60

NOMESCO Finland

Resection and reconstruction of leaflet of mitral valve for insufficiency

+∞

6.2

WX930

NOMESCO Finland

Thepapeutic hypothermia

+∞

6.2

4271A

ICD-9 Finland

Cardiac dysrhythmias, Paroxysmal ventricular tachycardia

+∞

6.2

FPD10

NOMESCO Finland

Surgical ablation of atrial fibrillation

+∞

6.2

5284

FHL

Mitral defect correction with flap prosthesis or graft

+∞

6.2

4276A

ICD-9 Finland

Cardiac dysrhythmias, Premature beats[EXTRASYSTOLIA SUPRAVENTRICULARIS]

+∞

6.2

4229X

ICD-9 Finland

Acute myocarditis, Other and unspecified acute myocarditis[MYOCARDITIS ACUTA NUD]

+∞

6.2

4291A

ICD-9 Finland

Ill-defined descriptions and complications of heart disease, Myocardial degeneration

+∞

6.2

AQ2

Electrophysiological electroanatomical examination

+∞

6.2

AC2

MVR bio

+∞

6.2

FME20

NOMESCO Finland

Transvenous aortic valve replacement via femoral artery

+∞

6.2

FPJ00

NOMESCO Finland

Revision of pacemaker pulse generator or electrode

+∞

6.2

FCA70

NOMESCO Finland

Resection of aortic root and ascending aorta with reimplantation of coronary arteries and use of biological valve prosthesis and tube graft

+∞

6.2

FPF00

NOMESCO Finland

Implantation of epicardial pacemaker with ventricular electrode

+∞

6.2

I44.3

ICD-10 Finland

Other and unspecified atrioventricular block

+∞

6.2

I30.8

ICD-10 Finland

Other forms of acute pericarditis

+∞

6.2

J96.1

ICD-10 Finland

Chronic respiratory failure

3.0

6.2

106

A07AA02

ATC

nystatin; oral

1.9

6.2

450

B04AB02

ATC

2.9

6.2

127

B01AB04

ATC

dalteparin; parenteral

2.0

6.2

343

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

1.6

6.2

154

990

M01AE03

ATC

ketoprofen; systemic, rectal

1.3

6.2

571

4691

WZB00

NOMESCO Finland

Telephone receipt or other advice

1.4

6.2

388

3013

B01AC07

ATC

dipyridamole; systemic

1.9

6.2

457

PG1DE

NOMESCO Finland

Other extensive ultrasound examination of artery

2.2

6.1

277

E10.2

ICD-10 Finland

Type 1 diabetes mellitus, With renal complications

4.7

6.1

J01FA09

ATC

clarithromycin; systemic

1.3

6.1

430

3397

Z73.3

ICD-10 Finland

Stress, not elsewhere classified

3.9

6.1

4100X

ICD-9 Finland

Acute myocardial infarction, Of anterolateral wall[INFARCTUS MYOCARDII ACUTUS DEFINITUS,MÄÄRITTELEMÄT]

2.6

6.1

161

ZXE04

NOMESCO Finland

Procedure duration 30 to 39 minutes

1.9

6.1

482

J01.0

ICD-10 Finland

Acute maxillary sinusitis

1.4

6.0

272

1990

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

1.7

6.0

108

632

R91

ICD-10 Finland

Abnormal findings on diagnostic imaging of lung

1.6

6.0

146

932

V03AE03

ATC

lanthanum carbonate; oral

10.0

6.0

NAME	I9_OTHILLHEART
CONTROL_EXCLUDE	I9_OTHHEART
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	I5[1-2]
HD_ICD_9	429
HD_ICD_8	42899\|42999
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	I5[1-2]
COD_ICD_9	429
COD_ICD_8	42899\|42999
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Parameter	HR [95% CI]	p-value
I9_OTHILLHEART	2.38 [2.04, 2.77]	< 0.001
Birth year	0.991 [0.98, 1.0]	0.038

Parameter	HR [95% CI]	p-value
I9_OTHILLHEART	2.371 [2.05, 2.75]	< 0.001
Birth year	0.989 [0.98, 1.0]	0.039

N-year risk	Females	Males
1	0.213%	0.452%
5	1.362%	2.737%
10	3.343%	6.988%
15	5.763%	13.198%
20	10.061%	21.709%

Other or ill-defined heart diseases

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints