No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
3751 |
4. Check minimum number of eventsNone |
3751 |
5. Include endpointsNone |
3751 |
6. Filter based on genotype QC (FinnGen only) |
3751 |
Control definitions (FinnGen only)
- Control exclude
- J10_PLEURA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- J90-J94
- Name in latin
- Lamellae pleurae
Similar endpoints
↥List of similar endpoints to
Pleural plaque
based on the number of shared cases.
Similar with more cases:
- Other diseases of pleura
- Other pulmonary diagnosis
- Excluding asthma or asthma-COPD overlap
- COPD differential diagnosis
- ILD differential diagnosis
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 22511 | 3209 | 19103 |
| Only index persons | 19742 | 2946 | 16796 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.47 | 0.09 | 0.53 |
| Only index persons | 0.56 | 0.11 | 0.64 |
| Median age at first event (years) | |||
| Whole population | 70.41 | 72.57 | 70.00 |
| Only index persons | 69.71 | 72.31 | 69.25 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3751 | 393 | 3358 |
| Unadjusted period prevalence (%) | 1.34 | 0.13 | 1.48 |
| Median age at first event (years) | 69.69 | 69.12 | 69.75 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 3371
- Matched controls
- 33710
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J92.0
ICD-10 Finland
Pleural plaque with presence of asbestos
4667.1
323.0
2458
19
J92.9
ICD-10 Finland
Pleural plaque without asbestos
3280.5
323.0
1177
5
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
6.6
323.0
1109
2336
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
202.5
323.0
362
20
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
13.6
323.0
716
653
J61
ICD-10 Finland
Pneumoconiosis due to asbestos and other mineral fibres
102.2
323.0
467
53
R03AC02
ATC
salbutamol; inhalant
3.4
237.8
1988
10111
UGC12
NOMESCO Finland
Flexible bronchoscopy
5.5
225.9
760
1700
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
4.1
211.5
997
3128
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
11.4
208.8
410
403
Z57.2
ICD-10 Finland
Occupational exposure to dust
155.8
194.9
205
14
R03BB04
ATC
tiotropium bromide; inhalant
4.2
192.6
866
2570
J94.8
ICD-10 Finland
Other specified pleural conditions
367.9
176.1
176
5
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
6.1
169.3
500
929
J96.1
ICD-10 Finland
Chronic respiratory failure
+∞
169.2
161
*
R06.0
ICD-10 Finland
Dyspnoea
3.0
165.3
1257
5526
XG410
NOMESCO Finland
Flow-volume spirometry
7.4
157.2
400
603
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
5.9
155.8
477
922
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
139.9
1986
12252
TGC00
NOMESCO Finland
Bronchial lavation
8.2
112.1
263
345
H02AB06
ATC
prednisolone; systemic
2.2
107.2
1784
11266
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
7.6
104.1
255
357
XX1AW
NOMESCO Finland
Written report from X-ray examination without contrast peformed elsewhere
29.6
96.4
131
46
J45.9
ICD-10 Finland
Asthma, unspecified
2.8
96.2
730
3021
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.6
94.4
836
3785
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
7.7
92.6
224
307
J92
ICD-10 Finland
Pleural plaque
+∞
83.7
80
*
R05
ICD-10 Finland
Cough
2.5
83.2
760
3467
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.7
80.0
642
2713
GD1AD
NOMESCO Finland
Thorax CT examination
4.6
79.4
294
683
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
3.7
77.6
371
1091
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
5.5
70.6
220
422
J45.1
ICD-10 Finland
Nonallergic asthma
3.7
70.1
335
981
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
3.3
65.3
356
1155
J98.1
ICD-10 Finland
Pulmonary collapse
140.8
65.1
69
5
J94.9
ICD-10 Finland
Pleural condition, unspecified
+∞
60.6
58
*
R03BA08
ATC
ciclesonide; inhalant
3.6
60.4
294
871
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
6.0
59.1
171
299
5110B
ICD-9 Finland
Pleurisy, Without mention of effusion or current tuberculosis[PLEURA-ADHEESIOT]
+∞
58.5
56
*
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
4.2
57.9
235
594
R03AK07
ATC
formoterol and budesonide; inhalant
2.4
57.5
582
2741
XX1XW
NOMESCO Finland
Extensive written report from radiologist
5.9
53.8
156
274
J96.0
ICD-10 Finland
Acute respiratory failure
186.2
53.1
55
*
Z57.3
ICD-10 Finland
Occupational exposure to other air contaminants
113.8
51.9
56
5
GAC00
NOMESCO Finland
Biopsy of pleura
56.4
51.7
61
11
J01AA02
ATC
doxycycline; systemic
1.8
51.6
2431
19855
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
2.7
50.8
389
1569
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
50.2
1163
7590
R03BA05
ATC
fluticasone; inhalant
2.2
48.0
555
2764
TGA30
NOMESCO Finland
Thoracocentesis
21.0
45.8
68
33
R03BA01
ATC
beclometasone; inhalant
2.3
44.6
484
2332
R02
ICPC
Shortness of breath/dyspnoea
2.3
43.8
474
2280
A02BC02
ATC
pantoprazole; systemic
1.6
41.8
2066
16503
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
8.4
40.1
90
110
SPAT1263
SPAT
Sampling
1.7
40.0
1384
9993
J01CA04
ATC
amoxicillin; systemic
1.6
38.6
2284
18928
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
3.9
36.8
157
415
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
8.6
36.3
80
95
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
4.5
35.3
128
290
C45.0
ICD-10 Finland
Mesothelioma of pleura
40.5
35.3
44
11
R03AK08
ATC
formoterol and beclometasone; inhalant
4.2
34.7
135
328
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
34.3
689
4191
GD5AD
NOMESCO Finland
Thorax and upper abdomen combined CT examination of
6.5
34.3
91
143
R04.2
ICD-10 Finland
Haemoptysis
2.9
34.2
223
811
N02BE01
ATC
paracetamol; systemic, rectal
1.7
34.0
2687
23561
R95
ICPC
Chron obstructive pulmonary disease
3.3
33.7
181
576
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
4.7
33.4
117
256
R06.2
ICD-10 Finland
Wheezing
3.3
32.4
169
526
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.9
32.3
583
3413
XG474
NOMESCO Finland
Exhalation nntrogen oxide
5.1
32.0
103
206
GAC01
NOMESCO Finland
Endoscopic biopsy of pleura
72.9
31.9
36
5
5119X
ICD-9 Finland
Pleurisy, Unspecified pleural effusion
+∞
31.3
30
*
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
31.2
1301
9666
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
8.5
31.2
69
83
R03BA02
ATC
budesonide; inhalant
1.9
31.0
490
2734
J93.1
ICD-10 Finland
Other spontaneous pneumothorax
156.3
29.7
31
*
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
4.3
29.6
113
270
R05
ICPC
Cough
1.8
29.1
624
3855
I50.9
ICD-10 Finland
Heart failure, unspecified
1.7
28.8
694
4439
GD1BA
NOMESCO Finland
Extensive X-ray examination of thorax
5.3
28.7
89
171
J47
ICD-10 Finland
Bronchiectasis
4.2
28.5
110
266
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
3.5
27.8
133
388
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
2.9
27.6
172
607
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.3
27.5
271
1237
C03CA01
ATC
furosemide; systemic
1.5
27.5
1314
9985
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.5
27.1
1422
11019
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.6
26.8
867
5993
R03AC13
ATC
formoterol; inhalant
2.7
26.2
185
707
SPAT1312
SPAT
General health counselling
1.6
26.2
952
6771
J01MA14
ATC
moxifloxacin; systemic
2.1
26.0
316
1583
J98.0
ICD-10 Finland
Diseases of bronchus, not elsewhere classified
251.9
24.7
25
*
R03BB01
ATC
ipratropium bromide; inhalant
2.5
24.6
207
869
SPAT1301
SPAT
No procedures
1.5
24.3
1078
7998
SPAT1058
SPAT
PEF monitoring instruction
2.1
23.3
279
1389
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.5
23.1
193
810
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
5.6
23.1
68
124
R01AD09
ATC
mometasone; nasal
1.5
22.5
973
7154
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
22.2
1253
9731
R03AC03
ATC
terbutaline; inhalant
1.9
22.1
355
1980
G47.3
ICD-10 Finland
Sleep apnoea
1.6
21.8
656
4421
SPAT1310
SPAT
Counselling related to known health issue
1.5
21.6
975
7218
R96
ICPC
Asthma
2.1
21.4
250
1232
SPAT1325
SPAT
Vaccination
1.4
21.3
1291
10144
A02BC05
ATC
esomeprazole; systemic
1.5
20.8
1112
8512
R5140
NOMESCO Finland
Monitoring the use of the aid
1.9
20.4
340
1920
M03BX02
ATC
tizanidine; oral
1.4
20.4
1389
11131
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
20.2
944
7017
J01FA06
ATC
roxithromycin; oral
1.5
20.2
1062
8090
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.8
20.2
385
2272
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.6
19.9
676
4679
R03DC03
ATC
montelukast; oral
1.9
19.9
326
1830
J43.9
ICD-10 Finland
Emphysema, unspecified
3.5
19.6
94
277
R03AK11
ATC
formoterol and fluticasone; inhalant
3.9
19.6
81
211
L03
ICPC
Low back symptom/complaint
1.6
19.5
574
3833
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.3
19.5
181
804
J01DB01
ATC
cefalexin; oral
1.4
19.3
2358
20904
J44
ICD-10 Finland
Other chronic obstructive pulmonary disease
2.9
19.1
116
404
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
4.5
18.9
68
155
J43.2
ICD-10 Finland
Centrilobular emphysema
10.7
18.9
36
34
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
4.0
18.6
74
186
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.4
18.6
1269
10121
J93.9
ICD-10 Finland
Pneumothorax, unspecified
190.9
18.5
19
*
R07.4
ICD-10 Finland
Chest pain, unspecified
1.5
18.5
870
6455
J45.8
ICD-10 Finland
Mixed asthma
3.1
18.0
99
323
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.4
18.0
1098
8564
SPAT1153
SPAT
Removal of sutures
1.4
17.8
1074
8354
J98.6
ICD-10 Finland
Disorders of diaphragm
+∞
17.7
17
*
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
2.8
17.7
117
431
XG466
NOMESCO Finland
Sleep oxymetry
2.7
17.5
121
458
R03AC18
ATC
indacaterol; inhalant
5.1
17.4
55
110
C07AB07
ATC
bisoprolol; oral
1.4
17.1
1776
15133
L08
ICPC
Shoulder symptom/complaint
1.6
17.0
529
3571
M54.5
ICD-10 Finland
Low back pain
1.5
17.0
768
5636
A02BC03
ATC
lansoprazole; oral
1.4
16.7
872
6581
J96.9
ICD-10 Finland
Respiratory failure, unspecified
35.2
16.7
21
6
N02AX02
ATC
tramadol; systemic, rectal
1.4
16.3
1315
10717
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.4
16.2
856
6471
J01MA12
ATC
levofloxacin; systemic
1.5
16.2
675
4864
UGC18
NOMESCO Finland
Flexible bronchoscopy with biopsy of lung
6.8
16.2
40
59
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.4
16.1
805
6015
A98
ICPC
Health maint/preventive medicine
1.4
16.0
2731
25168
R03AL08
ATC
vilanterol, umeclidinium bromide and fluticasone furoate; inhalant
3.6
15.9
71
199
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
1.5
15.5
738
5456
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.7
15.5
349
2160
N06AX11
ATC
mirtazapine; oral
1.4
15.4
747
5544
XG405
NOMESCO Finland
Education on PEF monitoring
4.0
15.4
62
159
XGX32
NOMESCO Finland
Bronchoscopic ultrasonography
5.2
15.4
47
91
9050/3-C38.4
ICD-O-3
Mesothelioma, malignant of pleura, NOS
38.2
15.4
19
5
R94.2
ICD-10 Finland
Abnormal results of pulmonary function studies
5.9
15.2
42
72
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.4
15.2
955
7433
SPAT1254
SPAT
Administration of medicine
1.5
15.0
494
3372
R03DA04
ATC
theophylline; systemic, rectal
1.9
14.9
231
1269
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
14.8
702
5179
GD5CD
NOMESCO Finland
Thorax and upper abdomen combined very extensive CT examination of
6.9
14.6
36
53
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.4
14.6
1041
8277
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.7
14.5
321
1978
J45
ICD-10 Finland
Asthma
1.9
14.4
219
1196
M01AC06
ATC
meloxicam; systemic, rectal
1.4
14.4
864
6664
J01FA15
ATC
telithromycin; oral
1.9
14.3
209
1124
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.4
14.3
865
6678
F1246
NOMESCO Finland
NA
17.0
14.3
22
13
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.4
14.2
1092
8775
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
4.0
14.2
56
142
G04CA02
ATC
tamsulosin; oral
1.3
14.1
1430
11999
R99
ICPC
Respiratory disease other
3.3
14.0
70
215
R01AD12
ATC
fluticasone furoate; nasal
1.5
13.9
491
3405
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.4
13.9
1134
9194
J01FA09
ATC
clarithromycin; systemic
1.4
13.8
656
4839
SPAT1097
SPAT
Recording of ECG
1.5
13.6
524
3700
C10AA01
ATC
simvastatin; oral
1.3
13.5
1763
15311
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
13.5
984
7825
A02BC01
ATC
omeprazole; systemic
1.4
13.5
863
6717
M01AH05
ATC
etoricoxib; oral
1.3
13.4
1323
11029
SPAT1059
SPAT
Spirometry at the office
2.0
13.4
177
919
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
2.1
13.3
145
695
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.0
13.2
165
837
J98.4
ICD-10 Finland
Other disorders of lung
40.2
13.1
16
*
TGD00
NOMESCO Finland
Needle biopsy of lung
6.2
13.0
34
55
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.4
12.9
112
484
R03BB07
ATC
umeclidinium bromide; inhalant
4.8
12.8
42
89
I50.0
ICD-10 Finland
Congestive heart failure
1.6
12.8
336
2164
M79.6
ICD-10 Finland
Pain in limb
1.4
12.7
870
6835
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
12.7
890
7017
SPAT1249
SPAT
Treatment-related counselling outside office
1.3
12.7
1109
9059
R06AE07
ATC
cetirizine; oral
1.4
12.5
863
6785
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.4
12.5
586
4302
H02AB04
ATC
methylprednisolone; systemic
1.6
12.4
371
2473
SPAT1260
SPAT
Consultation of another employee
1.5
12.3
531
3833
J43.8
ICD-10 Finland
Other emphysema
8.4
12.2
26
31
XG480
NOMESCO Finland
Histamine provocation of respiratroy tract
4.6
12.1
41
90
SPAT1257
SPAT
Teaching of medicine inhalation technique
2.2
12.1
123
573
C01DA14
ATC
isosorbide mononitrate; oral
1.4
12.1
792
6167
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.5
12.0
512
3684
J18.0
ICD-10 Finland
Bronchopneumonia, unspecified
2.8
11.9
74
264
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
11.7
1571
13581
GA3AT
NOMESCO Finland
Pleural cytology with ultrasound guidance
8.9
11.7
24
27
J42
ICD-10 Finland
Unspecified chronic bronchitis
3.4
11.7
56
168
UJF32
NOMESCO Finland
Coloscopy
1.4
11.7
810
6364
J20
ICD-10 Finland
Acute bronchitis
1.7
11.7
232
1386
R29
ICPC
Respiratory symptom/complaint other
2.0
11.6
155
809
Y96.0
ICD-10 Finland
Work-related condition
8.1
11.5
25
31
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.3
11.5
928
7462
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.5
11.5
455
3227
J94.1
ICD-10 Finland
Fibrothorax
+∞
11.5
11
*
51101
ICD-8 Finland
Pleurisy, Adhaesiones pleurae
+∞
11.5
11
*
R03AC19
ATC
olodaterol; inhalant
5.9
11.5
31
53
J46
ICD-10 Finland
Status asthmaticus
2.8
11.4
72
261
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.6
11.4
298
1920
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.3
11.3
834
6610
GD1AT
NOMESCO Finland
Biopsy of the lung with ultrasound guidance
7.0
11.3
27
39
D07AB02
ATC
hydrocortisone butyrate; topical
1.4
11.2
713
5519
R06AX27
ATC
desloratadine; oral
1.5
11.2
397
2751
XX1VW
NOMESCO Finland
Written report from radiologist
4.8
11.1
36
76
SPAT1053
SPAT
Memory test
1.4
11.1
690
5318
M01AE02
ATC
naproxen; oral, rectal
1.3
11.0
1327
11275
E0000UV
ATC
NA
1.3
11.0
962
7818
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.1
11.0
127
628
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.4
10.9
611
4622
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.7
10.9
221
1326
M01AE01
ATC
ibuprofen; systemic, rectal
1.3
10.8
2350
21540
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.3
10.7
978
7995
N03AX16
ATC
pregabalin; oral
1.4
10.6
591
4466
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.6
10.6
305
2015
AA1AD
NOMESCO Finland
CT of head and brain
1.3
10.6
828
6615
SPAT1211
SPAT
Application of soft bandage
1.6
10.5
268
1715
ZX109
NOMESCO Finland
Instruction on medicine inhalation technique
4.1
10.5
39
95
S18
ICPC
Laceration/cut
1.3
10.4
1306
11134
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.4
10.4
624
4780
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.5
10.2
342
2334
SPAT1043
SPAT
Audiometry
1.5
10.2
391
2748
WX725
NOMESCO Finland
Noninvasive ventilation
2.0
10.2
125
631
H25.1
ICD-10 Finland
Senile nuclear cataract
1.3
10.1
1019
8426
XQ800
NOMESCO Finland
Prick test
2.2
10.0
103
483
R03AC12
ATC
salmeterol; inhalant
1.9
10.0
150
820
C10AA05
ATC
atorvastatin; oral
1.3
9.9
1397
12059
D07AC13
ATC
mometasone; topical
1.3
9.9
745
5905
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.4
9.9
529
3964
XF402
NOMESCO Finland
ECG with work load test
1.5
9.9
390
2759
I27.8
ICD-10 Finland
Other specified pulmonary heart diseases
12.2
9.8
17
14
R03AL03
ATC
vilanterol and umeclidinium bromide; inhalant
3.0
9.8
54
181
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
1.7
9.8
204
1237
207
Kela drug reimbursment
Chronic arrhythmias
1.4
9.7
610
4698
R05DA20
ATC
opium alkaloids and derivatives - combinations
1.4
9.7
625
4838
M01AB05
ATC
diclofenac; systemic, rectal
1.3
9.6
1686
14930
8070/3-C34.3
ICD-O-3
Squamous cell carcinoma, NOS, of lower lobe, lung
5.0
9.5
29
58
5010A
ICD-9 Finland
Asbestosis[ASBESTOSIS]
10.0
9.5
18
18
J93.8
ICD-10 Finland
Other pneumothorax
100.3
9.4
10
*
9052/3-C38.4
ICD-O-3
Epithelioid mesothelioma, malignant of pleura, NOS
100.3
9.4
10
*
R03BB05
ATC
aclidinium bromide; inhalant
7.5
9.4
21
28
WX721
NOMESCO Finland
Oxygen concentrator therapy
17.6
9.4
14
8
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
1.5
9.4
303
2054
WX110
NOMESCO Finland
Local anesthesy
1.3
9.4
1674
14840
N40
ICD-10 Finland
Hyperplasia of prostate
1.3
9.3
1362
11780
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.4
9.3
489
3650
R28
ICPC
Limited function/disability (R)
3.0
9.3
50
166
I27.9
ICD-10 Finland
Pulmonary heart disease, unspecified
5.2
9.2
27
52
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.3
9.1
629
4914
J01CE02
ATC
phenoxymethylpenicillin; oral
1.2
9.1
1707
15189
L01
ICPC
Neck symptom/complaint
1.6
9.1
269
1785
GDA11
NOMESCO Finland
Thoracoscopic biopsy of lung
7.0
9.0
21
30
J01FA10
ATC
azithromycin; systemic
1.3
9.0
1087
9178
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.6
9.0
251
1643
R42
ICD-10 Finland
Dizziness and giddiness
1.3
9.0
643
5050
XX3DW
NOMESCO Finland
Time consuming IT work
1.5
8.9
311
2143
A07EC01
ATC
sulfasalazine; oral, rectal
1.7
8.9
185
1121
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.3
8.7
784
6364
AN1
HP
Coronary angiography
1.4
8.7
524
4006
J62.0
ICD-10 Finland
Pneumoconiosis due to talc dust
14.0
8.7
14
10
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.3
8.6
1027
8643
NH3EA
NOMESCO Finland
Feet X-ray examination with load
3.0
8.6
47
158
R03AL04
ATC
indacaterol and glycopyrronium bromide; inhalant
3.8
8.6
34
89
P01BA02
ATC
hydroxychloroquine; oral
1.8
8.6
155
902
J98.9
ICD-10 Finland
Respiratory disorder, unspecified
27.6
8.5
11
*
SAA02
NOMESCO Finland
Basic examination of mouth
1.2
8.5
1325
11514
J01DA01
ATC
[U] cefalexin; systemic
1.2
8.4
1694
15139
J94.2
ICD-10 Finland
Haemothorax
90.2
8.4
9
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.4
8.4
412
3038
51120
ICD-8 Finland
Pleurisy, Other specified forms of effusion, except tuberculous
+∞
8.3
8
*
R07.3
ICD-10 Finland
Other chest pain
1.5
8.3
250
1668
TGW99
NOMESCO Finland
Other minor procedure in thoracic surgery
8.5
8.3
17
20
C09CA06
ATC
candesartan; oral
1.3
8.2
543
4209
R13
ICD-10 Finland
Dysphagia
1.6
8.2
200
1268
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.4
8.2
382
2793
C34.31
ICD-10 Finland
Malignant tumor of the lower lobe, bronchus or lung epidermoid carcinoma
3.2
8.1
41
131
R53
ICD-10 Finland
Malaise and fatigue
1.3
8.1
551
4289
RS150
NOMESCO Finland
NA
33.4
8.1
10
*
GAA96
NOMESCO Finland
Other open or percutaneous drainage of pleural cavity
6.8
8.0
19
28
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.4
8.0
430
3222
L01CA04
ATC
vinorelbine; systemic
3.7
8.0
33
90
L17
ICPC
Foot/toe symptom/complaint
1.3
8.0
657
5260
K59.09
ICD-10 Finland
Constipation, unspecified
1.6
8.0
194
1229
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.4
8.0
378
2771
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.3
7.9
559
4377
UDC00
NOMESCO Finland
Ear microscopy
1.6
7.9
206
1328
M02AA07
ATC
piroxicam; topical
1.3
7.9
968
8158
NB1BA
NOMESCO Finland
Shoulder extensive X-ray examination without contrast
2.0
7.8
92
462
R78
ICPC
Acute bronchitis/bronchiolitis
2.5
7.8
58
236
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.2
7.7
1082
9260
R81
ICPC
Pneumonia
1.9
7.7
102
535
R05FB02
ATC
cough suppressants and expectorants
1.3
7.7
1027
8744
E000001
ATC
NA
1.4
7.7
472
3618
J82
ICD-10 Finland
Pulmonary eosinophilia, not elsewhere classified
5.9
7.7
20
34
XKD00
NOMESCO Finland
Uroflowmetry
1.3
7.7
868
7242
Z03.8
ICD-10 Finland
Observation for other suspected diseases and conditions
1.8
7.6
126
714
GAA31
NOMESCO Finland
Thoracoscopy
6.7
7.6
18
27
J37.0
ICD-10 Finland
Chronic laryngitis
2.1
7.5
85
418
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.3
7.5
540
4238
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
4.6
7.5
24
52
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
1.3
7.5
490
3790
D14.3
ICD-10 Finland
Benign neoplasm: Bronchus and lung
7.1
7.5
17
24
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.5
7.5
283
1987
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.5
7.5
237
1601
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.3
7.4
930
7850
GAC30
NOMESCO Finland
Artificial pneumothorax
80.2
7.4
8
*
JN4AD
NOMESCO Finland
Body CT examination
1.5
7.4
255
1757
M02AA10
ATC
ketoprofen; topical
1.4
7.4
371
2750
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.4
7.4
452
3463
R63.4
ICD-10 Finland
Abnormal weight loss
1.9
7.3
109
597
WZA90
NOMESCO Finland
Other doctors statement
1.3
7.3
488
3789
I10
ICD-10 Finland
Essential (primary) hypertension
1.2
7.3
2062
18977
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
1.6
7.2
197
1285
A02BA02
ATC
ranitidine; systemic
1.3
7.1
598
4790
D07AC01
ATC
betamethasone; topical
1.3
7.1
907
7661
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
1.8
7.1
120
684
A01AB09
ATC
miconazole; local oral
1.6
7.1
199
1307
R06.8
ICD-10 Finland
Other and unspecified abnormalities of breathing
2.9
7.0
40
138
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.4
7.0
355
2636
R21
ICPC
Throat symptom/complaint
1.5
7.0
253
1761
284
Kela drug reimbursment
Nintedanib and pirfenidone
3.6
6.9
29
81
L04AA13
ATC
leflunomide; oral
2.6
6.9
47
183
WX722
NOMESCO Finland
PEEP
1.7
6.9
149
915
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
3.2
6.9
33
103
356
Kela drug reimbursment
Nintedanib and pirfenidone
3.9
6.8
26
67
JN3AD
NOMESCO Finland
Abdominal CT examination
1.5
6.8
217
1470
GX1K5
NOMESCO Finland
Diffusion capacity
8.3
6.8
14
17
J84.0
ICD-10 Finland
Alveolar and parietoalveolar conditions
8.3
6.8
14
17
F2680
NOMESCO Finland
NA
8.3
6.8
14
17
J62.8
ICD-10 Finland
Pneumoconiosis due to other dust containing silica
9.3
6.8
13
14
M48.0
ICD-10 Finland
Spinal stenosis
1.4
6.8
397
3016
M03BC51
ATC
orphenadrine, combinations; systemic
1.3
6.7
510
4026
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
1.4
6.7
268
1900
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.0
6.7
79
397
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
1.6
6.7
165
1049
Z51.5
ICD-10 Finland
Palliative care
1.5
6.7
218
1485
A07AA02
ATC
nystatin; oral
1.6
6.7
157
989
N07BA03
ATC
varenicline; oral
2.1
6.7
74
362
I48.1
ICD-10 Finland
Persistent atrial fibrillation
1.8
6.6
101
557
H13
ICPC
Plugged feeling ear
1.3
6.6
614
4982
R01AD08
ATC
fluticasone; nasal
1.3
6.6
534
4255
I50
ICD-10 Finland
Heart failure
1.7
6.6
123
724
SPAT1101
SPAT
Orthostatic test
1.6
6.6
158
998
348
Kela drug reimbursment
Roflumilast
5.5
6.6
18
33
NA1AD
NOMESCO Finland
Cervical spine CT examination
1.8
6.5
106
599
J01FF01
ATC
clindamycin; systemic
1.3
6.5
668
5496
GAC37
NOMESCO Finland
Endoscopic chemical pleurodesis
70.0
6.4
7
*
SAA03
NOMESCO Finland
Extended examination of mouth
1.3
6.4
751
6272
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
1.4
6.4
272
1954
G04CA01
ATC
alfuzosin; oral
1.3
6.4
618
5046
H04.10
ICD-10 Finland
Dry eye syndrome
1.5
6.3
178
1172
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
1.5
6.3
196
1322
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.5
6.3
206
1404
1240
FHL
Bronchoscopy
2.4
6.3
49
207
TGA10
NOMESCO Finland
Needle biopsy of pleura
26.7
6.2
8
*
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
1.4
6.2
246
1746
B01AA03
ATC
warfarin; systemic
1.2
6.2
889
7596
N03AX12
ATC
gabapentin; oral
1.4
6.1
353
2672
SPAT1262
SPAT
Handing over of treatment supplies
1.3
6.1
608
4975
GA4AT
NOMESCO Finland
Cathetrisation of pleural cavity with ultrasound guidance
3.1
6.1
30
96
7170A
ICD-9 Finland
Internal derangement of knee, Old bucket handle tear of medial meniscus
1.9
6.1
83
444
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.5
6.1
212
1465
SPAT1099
SPAT
Measurement of blood pressure with Doppler ultrasound device
1.7
6.1
126
768
N02AA01
ATC
morphine; systemic, rectal
2.2
6.0
56
257
A06AD11
ATC
lactulose; oral
1.3
6.0
511
4099
D38.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pleura
6.7
6.0
14
21
A06AC01
ATC
ispaghula (psylla seeds); oral
1.3
6.0
594
4858
Mortality – FinRegistry
↥Association
Association between endpoint J10_PLEURPLAGUE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_PLEURPLAGUE | 1.23 [1.1, 1.37] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.658 |
During the follow-up period (1.1.1998 — 31.12.2019), 1033 out of 2963 females with J10_PLEURPLAGUE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_PLEURPLAGUE | 1.37 [1.26, 1.49] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 7086 out of 17328 males with J10_PLEURPLAGUE died.
Mortality risk
Mortality risk for people of age
years, who have J10_PLEURPLAGUE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.142% | 0.227% |
| 5 | 0.715% | 1.345% |
| 10 | 1.869% | 3.572% |
| 15 | 3.924% | 6.586% |
| 20 | 7.039% | 11.352% |
Relationships between endpoints
↥Index endpoint: J10_PLEURPLAGUE – Pleural plaque
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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